LOCUS       NZ_CP053892            27053 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5031407
            Orig. end                         :: 5058460
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..27053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="16"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..27053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27053
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:17053]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17053
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            877..2088
                     /locus_tag="ACTIVE_RS21780"
                     /old_locus_tag="ACTIVE_4353"
     CDS             877..2088
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017582315.1"
                     /locus_tag="ACTIVE_RS21780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4353"
                     /product="sensor domain-containing protein"
                     /protein_id="WP_173096788.1"
                     /transl_table=11
                     /translation="MLAAAVPFGMLVLPWAAALSSRYGIGARLLLVALGVLFVAGLGPL
                     VALPIAEVERRRLRLVDVRPIVSAHSRVNGSEPRTWSLVRYGESAIWREMAYASLLVTV
                     VPVLYAALLMYVFTIAGLAFSPLLAQGDGEPVALGLAKVATPTDAIPYALAGLALLPSI
                     PYLAAVLAGAHGAMARSLLGRGSGERLRAELVEVSRSRARLVDAFEAERRRIERDLHDG
                     AQQRLIGLTLKLGMARVDLPADSDAGRNVSEAHEQAKLLMDELRELIRGIHPRVLTDRG
                     LPAALRELADHSPVPVTVETDLPERLPPHEEGTAYFVAAEALSNIAKHSGAQNGQIRAH
                     LRDGTLALEVEDDGKGGANPALGSGLTGLADRVAVIDGRMLLSSPAGGPTVLRVEFPCS
                     RPSE"
     gene            2067..2732
                     /locus_tag="ACTIVE_RS21785"
                     /old_locus_tag="ACTIVE_4354"
     CDS             2067..2732
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017592483.1"
                     /locus_tag="ACTIVE_RS21785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4354"
                     /product="response regulator transcription factor"
                     /protein_id="WP_173096789.1"
                     /transl_table=11
                     /translation="MQPTVRVVLAEDGVLLREGLVGLLGKFGFDVVAAVEDADALKAAV
                     EEHAPDLVVTDIRMPPGFSDEGLRAAVELRKAHPGLAVVALSQYVELSYSADLLDSNGG
                     TSVGYLLKDRVVDVEEFVAALRRVVDGGTVVDPTVVRQLLRRSRDPLSRLSAREREVLA
                     LIAEGHSNTAIAQILTVAEVTVGKHIGNILTKLDLPLTDDKNRRVLAVLTYLRSRAAA"
     gene            complement(2729..3172)
                     /locus_tag="ACTIVE_RS21790"
                     /old_locus_tag="ACTIVE_4355"
     CDS             complement(2729..3172)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615319.1"
                     /locus_tag="ACTIVE_RS21790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4355"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_246343049.1"
                     /transl_table=11
                     /translation="MEDHEAIVRAMPDWWADSRTPEQARQLTLLLPRLFFEHFSGTSLV
                     MDGDDGMDGFLVGFHSADHPDEAYIHFVGVDPTRRKGGIARALYERFFEEAAAAGLTKV
                     KAITSPANTGSIAFHQAMGFDVHEPRPGYDGPGQDRVRFEKTL"
     gene            3326..3874
                     /locus_tag="ACTIVE_RS21795"
                     /old_locus_tag="ACTIVE_4356"
     CDS             3326..3874
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF044515.1"
                     /locus_tag="ACTIVE_RS21795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4356"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_173096791.1"
                     /transl_table=11
                     /translation="MPRADAQRNRDLILTAAKKVFTERGPSAPLDDIARRAGVGNATLY
                     RHFPTRRDLLVAVYSDEVTDLTTQGRDLLRQDPPADALFTWLRAFITHVADKADLARAI
                     PEDGRSPLFDQWHAAMHTALAPLLARAQETGAVRPDLDGRDLLALAGGIATAGSGAAQT
                     DRLLRLVREGIATPAQTPN"
     gene            3930..4478
                     /locus_tag="ACTIVE_RS21800"
                     /old_locus_tag="ACTIVE_4357"
     CDS             3930..4478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893879.1"
                     /locus_tag="ACTIVE_RS21800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4357"
                     /product="YciI family protein"
                     /protein_id="WP_173096792.1"
                     /transl_table=11
                     /translation="MEFFCYHRDRRDSLALRYELLEEHWSYMDGYAAEMIARGPTLAED
                     GETPTGSVHIVDLPDASAARAFAFDEPGYQAGAYRDVMLRRWHNTLGRTMWEFTGDRTE
                     GTHYLVLGLGAGHTADQDVPPDHHTLIAYGPLLSDDGSTWLGTAALLHAPTPEAARTVL
                     TADRYAEIEVHDWTFGGRR"
     gene            complement(4535..5272)
                     /locus_tag="ACTIVE_RS21805"
                     /old_locus_tag="ACTIVE_4358"
     CDS             complement(4535..5272)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545225.1"
                     /locus_tag="ACTIVE_RS21805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4358"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_173096793.1"
                     /sec_met_domain="APH (E-value: 1.3e-22, bitscore: 80.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEVEVVVAHSERATLRVGDVFLKVDADQSRIDVEVEAMALVPVP
                     TPKVLWRKPPVLAISAVPGTALGRLGEPSTASPAAWAAAGAAIRTLHDAPLPPWPGRGP
                     GELAAELDAECERLLASDVLPSDLVMRNRQVAEAALRPWTPVFTHGDLQITHVFVDGDE
                     VTGIIDWSEAGPGDALFDLAILTLGHEERLDDVIAGYGADVDRDVIRAWWSLRSLLAVR
                     WLAEHGFDPSAPGCEVDVLRARM"
     gene            complement(5401..5697)
                     /locus_tag="ACTIVE_RS21810"
     CDS             complement(5401..5697)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013130699.1"
                     /locus_tag="ACTIVE_RS21810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_216858519.1"
                     /transl_table=11
                     /translation="MERTVIIRSASEKTRMASDCPDALVSYSARFDECGLIVHDGGGSV
                     ISIAFCPWCGTRLPPSQRDAWFDALERRGIDPGEDDVPPEFQTAAWRTASPAD"
     misc_feature    complement(5708..5726)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.12"
                     /tool="antismash"
     gene            complement(5760..6218)
                     /locus_tag="ACTIVE_RS21815"
                     /old_locus_tag="ACTIVE_4359"
     CDS             complement(5760..6218)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS21815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_4359"
                     /product="hypothetical protein"
                     /protein_id="WP_173096794.1"
                     /transl_table=11
                     /translation="MSTDETNGLVRSLTPEDRQAVALLDLQVLAAENAGRDFQDTTPTY
                     GVLNCLRFWEILISRMEEGWRRQDYYMVYEYLNVLTVRSGIEEFLDAMPTALRTKTDRC
                     VGRLDARYRAVTYEDGGAELSHYHRPLADGREVRWWYTRRPNELPPGW"
     gene            complement(6215..6865)
                     /gene="msrA"
                     /locus_tag="ACTIVE_RS21820"
                     /old_locus_tag="ACTIVE_4360"
     CDS             complement(6215..6865)
                     /EC_number="1.8.4.11"
                     /GO_function="GO:0008113 - peptide-methionine (S)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_function="GO:0033744 -
                     L-methionine:thioredoxin-disulfide S-oxidoreductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632372.1"
                     /locus_tag="ACTIVE_RS21820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4360"
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="WP_173096795.1"
                     /transl_table=11
                     /translation="MFGFAKTRMVSPEKALPGRDEPIPVPPRHEVLDAPLAPPFPDGTE
                     VAEFALGCFWGAERKFWQTPGVVSTSAGYEGGYTPNPTYEEVCSGLTGHTETVRVVYDP
                     SRVSYDDLLRVFWEAHDPTQGMRQGNDVGSQYRSAIFARTDGQLKAAEASRDAYQPVLT
                     AAGYGPITTCITPATDFYYAEDYHQQYLQKNPNGYCGIGGTGLSCPTGIAPAE"
     gene            7004..7378
                     /locus_tag="ACTIVE_RS21825"
                     /old_locus_tag="ACTIVE_4361"
     CDS             7004..7378
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS21825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_4361"
                     /product="hypothetical protein"
                     /protein_id="WP_173096796.1"
                     /transl_table=11
                     /translation="MRLLSVTVLGTALVAAGLLAPAAGEATTSQQDGLTVRPGTVRAGQ
                     KVELSVPGCGPGRHRASSDAFDGRALLDDSDGTATIKDGVRPDTYRVSVDCGRRKVTGK
                     VRVAGRLGWPALLPDLRNGR"
     misc_feature    complement(7512..7526)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.76"
                     /tool="antismash"
     gene            7714..9087
                     /locus_tag="ACTIVE_RS21830"
                     /old_locus_tag="ACTIVE_4362"
     CDS             7714..9087
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="ACTIVE_RS21830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4362"
                     /product="cytochrome P450"
                     /protein_id="WP_173096797.1"
                     /sec_met_domain="p450 (E-value: 4.2e-70, bitscore: 235.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVDVASVPAAKAKNFPLYRTVTGFVRDPLRELERISKESDGRLI
                     RLDLGASHPYLATHPDHVQQVLRRESQNFLRDGIFWRPLRELMGDSILSEGGEWEHSKR
                     VLQPVFTTRNVNRLTGMMAEAINTAVGKLDAPAREGRPIDVLPEMSRIVNETVIKVLFG
                     DKISPVEANRLIPTFDQIATSISVRFLLPFVPRALPMPGDRAFKDAVQVMDEVLFELVK
                     RYRDDPGDGSDIFTALCQAPTEDGAPPDDRWIRDNLLAMFATSTETTTLALTWLWPLLH
                     DHPDVEARLVEEIDAVVGGEPVRPEHLHRLPYVTQVVQELLRLYPVGWMFPRMATEATT
                     IGGVPIKPGDPVLISPFLTHRLASVWDRPLEFDPERFTPENIRKRHRYAYFPFGGGPHQ
                     CIGRHVFNVEAQMILTSILSRFRPTLSEAVPAMPKIGATLRPRQSLEMTLTPVAGHGA"
     gene            9084..10004
                     /locus_tag="ACTIVE_RS21835"
                     /old_locus_tag="ACTIVE_4363"
     CDS             9084..10004
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889881.1"
                     /locus_tag="ACTIVE_RS21835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4363"
                     /product="terpene synthase family protein"
                     /protein_id="WP_173096798.1"
                     /transl_table=11
                     /translation="MTAADGAASRPSGLARPDALADARETGAVMAQAVKCARDLAACAA
                     DHPGLFDAKPIDETLFNAVACANAFGSPWLDAAGIRMAARTSLWIFGLDWLVDHVAAER
                     AEIEDINRRCLAVADGAPPVPGDGLTQFLAEIRDEVAQSPAFASLRGDWRAQLRRLLEC
                     GAREWDWKSGDRAAWPTFDEYLDNADNYGSAWVNVSHWIVHADAGVLAHAGELQVVSRE
                     VQRILRLLNDLATYERDVTWGDLNAQMLGVDRATITERIGRIVERCGELLAPLRADCPE
                     AVAYLERQIGYSTGFYELSDYWGSL"
     gene            10001..11761
                     /locus_tag="ACTIVE_RS21840"
                     /old_locus_tag="ACTIVE_4364"
     CDS             10001..11761
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654755.1"
                     /locus_tag="ACTIVE_RS21840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4364"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_173096799.1"
                     /sec_met_domain="T2TS (E-value: 1e-79, bitscore: 267.5,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVGEAEPSTASGEPPPAEVAEAANALVGGLVEAPWGTASASVYE
                     TGRVVSLAPWLTGHVRRLRFLLDQQRPDGGWGPPDAGYSLVPTLSATDALLSTLVPEGR
                     AWADGADRAEVASAAERALRLLGDWLDEDGTPDFPDMPAIEHITPSLIEAINGRLDRLR
                     PAPSGDPAFGWSGRLRPPAGMDGSLLPSVRKHLADGGAVPVKLLHALEIAGSSAHGAAA
                     VRPVDVPAPPGVTKSTTFATVGASAAATAAWLGTRGADGGGDPDGAARRYLEAAAGQWG
                     GPVPVATPITNFERGWVLGWLARAGIPFAVPPRLIAEMRASLGEDGAPGGPGLPPDADT
                     SSGVLYALSLLNEPVPPDLLWRYEAGAHFSSWPGEDGRSVTTNAHVLEAFGHFARSVGP
                     GPSGRYAATVRKVAYWLADQQGDEGSWTDRWHASPLYATACCALALDAFGGPDAVPAVD
                     RAVRWVIREQRADGSWGRWDGTAEETAYAVQILCLTRAAAGERPGVPAGDAVAAVRRGD
                     DHLRAAVRRRSEGLRGPGPEGVRGRVADIDSGKHPLWHDKDLYRPITIVQAAVLGALHL
                     ARSDARVSRR"
     misc_feature    complement(11970..11981)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.34"
                     /tool="antismash"
     gene            11972..14461
                     /locus_tag="ACTIVE_RS21845"
                     /old_locus_tag="ACTIVE_4365"
     CDS             11972..14461
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889883.1"
                     /locus_tag="ACTIVE_RS21845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4365"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_173096800.1"
                     /transl_table=11
                     /translation="MRFRNSRLRTKIAALLLSLTALWVFAAWVTLREGVNLLFVNTLDS
                     VVAPSDPLLVDLQQERRLTVTMLASGRLSPDQLAAARARTDKDREIVVRKARSGAVRRA
                     ADGSMDKRLEQMVDQLASLDQERRSIDAGAFDRHRAVQAYSDVIESIFHMYDGTTTLDD
                     RGFTTALRAEIAVNRSWELLSQEDAIVAGVLATGRITVADRIDIAQAIGARRLNYSRAM
                     IDLEPADRQAWNELNTDKRLATVRAMEDVLLQQRTRTMVPRISADQWRAATTPALAQMR
                     TSIQDAGDRLVERATPIAAWVIVRLVLAGGLGLLAVIASIVVSITTARALVRQLERLRT
                     AAWELAEQRLPGVVERLGHGEKVDVSVEAPPLQFGTDEIGQVGRAFNAVQETAIRTAVE
                     QAELRRGIRDVLLSLARRTQTLVHRQLTMLDTMERRRDIEVKELEELFRLDHLATRMRR
                     NAENLIVLSGALPARGWRSSVPMIDVVRAAVGEVEDYTRVTVLPFGPVELAGRAVGDVT
                     HLLAELIENAVSFSPPDTVVQVGGHLVANGFAIDIEDRGLGMTDEKLAEINARIEDPPD
                     FNLQSSVQLGLFVVSRLAERYGLRVSLKRSAYGGTTAVVVVPTELVVEESDRVRAPAAT
                     TTQNGLEVRQPTAVGARSGGPAALTTGGTGPQPAPSAPALVAVPPPAPEPGETPVPPSG
                     QGPNGSPERGLPRRQDEPPAGGARSHDGAPSTPPGHTGAGGGHPEPTQPEDLPPVPDIS
                     TTPSGLPVRVPQANLAEPLRTDEPIVAEEPDETDDPGRSPEEIQRIMGSYQRGTRRGRS
                     DAAEALGNEAAEGEEGQ"
     gene            14458..14883
                     /locus_tag="ACTIVE_RS21850"
                     /old_locus_tag="ACTIVE_4366"
     CDS             14458..14883
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133477.1"
                     /locus_tag="ACTIVE_RS21850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4366"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_173096801.1"
                     /transl_table=11
                     /translation="MTQKTGSSSDLGFLLDDLVHRLPHARNAVVLSADGLLMASSAGMT
                     QDDGEHLSAVAAGIQSLAKGAGTRFGGGPVRQTIVEMQSAFLLVSVAGKGACLAVLAGE
                     EADVGLIAYEMAMLVTSMGHHLTTPSRSEAAEEGRPA"
     gene            14880..15308
                     /locus_tag="ACTIVE_RS21855"
                     /old_locus_tag="ACTIVE_4367"
     CDS             14880..15308
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654752.1"
                     /locus_tag="ACTIVE_RS21855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4367"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_173096802.1"
                     /transl_table=11
                     /translation="MMPPEEPGQEPWPQDPALHTPGHERVYDESAGPMVRPYVMTSGRI
                     EPVHGKFDLITLVVAAGPEPEGAIGLGPEHLAIIQLCRQVMSVAELTGHLDLPVATVRV
                     LLGDLLGKGLVTLQEPEPEADMHDIRLYKAVIDGLRAL"
     gene            15346..15915
                     /locus_tag="ACTIVE_RS21860"
                     /old_locus_tag="ACTIVE_4368"
     CDS             15346..15915
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632363.1"
                     /locus_tag="ACTIVE_RS21860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4368"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_173101336.1"
                     /transl_table=11
                     /translation="MPTAVKIVIAGGFGVGKTTMVGTVSETRPLRTEEILTDESVGVDD
                     ISGVERKKTTTVAMDFGRLTFRDEYVLYLFGTPGQERFWFMWDEVSLGALGAVVLADTR
                     RLSDCFPSVDYFERRGTPFVVAVNCFEGAKQYDLAEIQLALNLGPKVPVMLCDARRLDS
                     CKQVLIDLVLHAMKYRGLPALETQGA"
     gene            complement(16025..17053)
                     /locus_tag="ACTIVE_RS21865"
                     /old_locus_tag="ACTIVE_4369"
     CDS             complement(16025..17053)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854714.1"
                     /locus_tag="ACTIVE_RS21865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4369"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_173101337.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.3e-55, bitscore:
                     186.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEKSGGPARQESGPFGLPVDSALAADARQRLAAVEELLLESVRG
                     EDPLLSQASKHLVEAGGKRFRPMLVLLASHFGDPAAAGVVPAAVVVELTHLGTLYHDDV
                     MDEATVRRGQASANSRWTNTVAILTGDYLFARASDLLADLGPEAVRIQARAFARLVRGQ
                     IQETVGPAEGADPLKHYLQVAADKTASLIAVSGQFGSLLSGAPAHVVDTITSACEKIGV
                     AFQLSDDILDIDSETEESGKTPGTDLREGIRTLPMHHVLAGVGSGPDDARLRELLVQDL
                     SGDELHAEALALLRAHPAMDLARADLRQCAEDARAELLTLPAIPARDAFTGLCDFVVSR
                     TG"
     gene            complement(17076..18659)
                     /gene="nuoN"
                     /locus_tag="ACTIVE_RS21870"
                     /old_locus_tag="ACTIVE_4370"
     CDS             complement(17076..18659)
                     /EC_number="7.1.1.2"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632351.1"
                     /locus_tag="ACTIVE_RS21870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4370"
                     /product="NADH-quinone oxidoreductase subunit NuoN"
                     /protein_id="WP_173101338.1"
                     /transl_table=11
                     /translation="MAHGVLAQGGDIPAPHIEYGQIGPLLLVLGIAVAGVLAEAFVGRT
                     WRYAVQVPVAFLGLAGAFVWTVLLGWRDNPHHVAAQGALGVDGPTLFIQGTVLVLALVS
                     LLLIAERGNGRSGGIVGGHFAAQASALPGSEDEQRTTAAGITQTEVFPLMMFAVAGMMM
                     FPAANDLLTMFVALEVMSLPLYLLCGLARRRRLLSQEAAVKYFLLGAFSSAFFLYGTAL
                     LYGYAGSVRLSDISAQVSKDAGSETLLLAGVALLSVGLLFKLGGVPFHMWKPDVYQGAP
                     TPITALMASCTVVAAFGGILRVYYVAFETLKWDWRPYMWGVAILTMVVGAIIAITQSDI
                     KRMLAYSSIAHAGFLLMGVVATSRDGLSSTMFYLVAYGFTSIGAFAVVTMVRDAGGEAG
                     HLSRWAGLGKRSPVVAGVFSFFLLAFAGIPLTSGFTGKFAVFKAAVESGATPLVVVGVI
                     SSAVAAFFYVKVIVVMFFSEPEADGPVVVAGPATAAAVALGATATVVLGVIPQPVLDLA
                     GHATTHMFVR"
     gene            complement(18686..20275)
                     /locus_tag="ACTIVE_RS21875"
                     /old_locus_tag="ACTIVE_4371"
     CDS             complement(18686..20275)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632350.1"
                     /locus_tag="ACTIVE_RS21875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4371"
                     /product="NADH-quinone oxidoreductase subunit M"
                     /protein_id="WP_173096803.1"
                     /transl_table=11
                     /translation="MSDFPWLSVLIALPLLGAVAVSVLPRDNEPLVKWFSFGVSTLVGV
                     LALAMAAGFDAGGDRFQFTEKYWWIKEFGIHWALGVDGVALVLILLSVILVPLVMLASW
                     NEDERSGGVDVPAKRSVKTYFALLLSLEAAMIGVFAATDVFLFYVFFEAMLIPVYFIIG
                     HYGGGAARERSYAAVKFLLYSLFGGLLMLVSVIWLYPLSNKPVAEGGLGHGTFMFQELR
                     GLHVDPTTAKWLFLGFFIAFAIKAPMVPVHTWLPTAAQQSPPGALVLIVGVLDKVGTYG
                     MLRFCLELFPGASKWATPAVLVFAVISIIYGAILAIGQVDLKRLIAYTSVSHFGFIVLG
                     IFAMTSQGQSGAALYMVNHGFSTGALFLLVGFMIVRRRSAKITDFGGVQKAAPVLAGTF
                     LIAGLSGLSLPGLSPFVSEFLVLVGTFSRYKVAACFAVTGVVLAAIYVLWMYQRTMGGP
                     KVPAVEGMKDLTAREKWAVAPIIAIIVAMGFFPQPVLHVINPSVKETLARVDRHDPAPT
                     LTGNVAENGARP"
     gene            complement(20272..22188)
                     /gene="nuoL"
                     /locus_tag="ACTIVE_RS21880"
                     /old_locus_tag="ACTIVE_4372"
     CDS             complement(20272..22188)
                     /EC_number="7.1.1.2"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632349.1"
                     /locus_tag="ACTIVE_RS21880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4372"
                     /product="NADH-quinone oxidoreductase subunit L"
                     /protein_id="WP_173096804.1"
                     /transl_table=11
                     /translation="MKAEGIQAASWLLIALPLVGAAILLLGGRRTDKWGHLLGVATPVA
                     SFAIGIAMLVQMLGYDDAARRRTVHLWDFINVGGFKIGMDLLVDPLSISFVLLITGVGS
                     LIHIYSVGYMAEDPDRRRFFAYLNLFVAAMLLLVLGGNFLVLFLGWEGVGLASYLLIGF
                     WQHKPTAATAAKKAFVVNRVGDMGLIIAIALMFSTFGTVDFGPILGAGAEHAGLAAKLS
                     TGTATAIGLLLLLGACGKSAQLPLQSWLLDAMEGPTPVSALIHAATMVTAGVYLIVRSG
                     PIFEMSETAQLVVTIVGAATLLAGAIIGCGKDDIKKALAGSTMSQIGYMTLAAGLGRPG
                     YVFAIAHLIAHGFFKAGLFLGAGSVMHGTNDDVNMRHYGALRGVMMATYVTFGLGFLAI
                     IGFPFLSGWFTKDAIIEAAFDKGGTSGAILGVCAVIGAGITAYYMSRVMIMTFFGEKRW
                     EEGVHPHESPKVMTIPLMLLAVGSVFAGGWLILGGFSDFLEPVTGKPEHAESFKWVTLP
                     GIVVLVLMVIGFAIAWMQYGRRPVPREAPAGSFVTVAARKDLYGDAINESLLMRPGQWL
                     TRLAVWFDGRGVDGAVNGLAALIGGTSGRFRRIQTGFARSYALSMFFGAALVVAALLVV
                     NVS"
     gene            complement(22199..22498)
                     /gene="nuoK"
                     /locus_tag="ACTIVE_RS21885"
                     /old_locus_tag="ACTIVE_4373"
     CDS             complement(22199..22498)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /GO_process="GO:0042773 - ATP synthesis coupled electron
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014912309.1"
                     /locus_tag="ACTIVE_RS21885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4373"
                     /product="NADH-quinone oxidoreductase subunit NuoK"
                     /protein_id="WP_173096805.1"
                     /transl_table=11
                     /translation="MSPGHYLALSAILFTIGGLGVLVRRNAIVVFMCVELMLNATNLAF
                     VTFSRMHGTLDGQIIAFFVMVVAAAEVVVGLAIIMTIFRTRRSSSVDDANLLKY"
     gene            complement(22495..23412)
                     /locus_tag="ACTIVE_RS21890"
                     /old_locus_tag="ACTIVE_4374"
     CDS             complement(22495..23412)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854719.1"
                     /locus_tag="ACTIVE_RS21890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4374"
                     /product="NADH-quinone oxidoreductase subunit J"
                     /protein_id="WP_246343169.1"
                     /transl_table=11
                     /translation="MLAGHVADKQSGEPFFFWLLAVVSVCAALGMILVRKAVHSALLLA
                     TVMLCLAAMYAIQNAPFLAFVQVIVYTGAVLMLFLFVLMLVGVTSTDSLVETIKGQRFW
                     AVIVAIGFIVLLGTGLGNAALGDSAGLKAANADGNVLGLARLLFTKYVFAFEATSALLI
                     TAALGAMVLAHRERTEPKPTQKDLSKRRFASGEHPGPLPGPGTYARHNAVDMPALLPDG
                     TPSELSINPVIAARTDTAERHADLYGGTEQGAMDEDIAAVKAATEEAKDADAESRVVRA
                     GTPAAGGDAGGGAGGNEREGEAGQ"
     gene            complement(23451..24005)
                     /gene="nuoI"
                     /locus_tag="ACTIVE_RS21895"
                     /old_locus_tag="ACTIVE_4375"
     CDS             complement(23451..24005)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011293110.1"
                     /locus_tag="ACTIVE_RS21895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4375"
                     /product="NADH-quinone oxidoreductase subunit NuoI"
                     /protein_id="WP_246343170.1"
                     /transl_table=11
                     /translation="MFMKSETVQYPEVKKPTAPRFHGRHQLNRWPDGLEKCVGCELCAW
                     ACPADAIFVEGADNTEDERYSPGERYGRTYQINYLRCILCGLCIEACPTRALTMTNEYE
                     LADDSRESLIYTKDMLLAPLREGMEAPPHEMRLGDTEEDYYRLGLQPEDAAPTVPSEGG
                     GRASADNAVKREKAGKGGEGK"
     gene            complement(24049..25386)
                     /gene="nuoH"
                     /locus_tag="ACTIVE_RS21900"
                     /old_locus_tag="ACTIVE_4376"
     CDS             complement(24049..25386)
                     /EC_number="1.6.5.9"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654731.1"
                     /locus_tag="ACTIVE_RS21900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4376"
                     /product="NADH-quinone oxidoreductase subunit NuoH"
                     /protein_id="WP_173096808.1"
                     /transl_table=11
                     /translation="MSPLAAPAADPTLATFGKDPWWLIGGKVLVIFVFLVLTVLLSMWV
                     ERRVIGRMQLRVGPNRCGPFGLLQGLADGVKLALKEDIVPRQVDKVVFVLAPVMSAVPA
                     FISFIIIPFGPTVSVFGHHTALQGTDLPVAVLLVLAMSSMGIYGVVLAGWSSMSPYSLL
                     GGLRSSAQMISYEIAMGLSFVAVFMFAGSMSTSEIVAKQDHIWFAVLLAPSFVVYVITM
                     MGESNRIPFDLPEGEGELVGGFHTEYSSLKFAMFFLAEYINLATLSALATTLFLGGWRA
                     PAPISTVWAGANSGWWPVLWFMIKLWLFIFFFIWLRGSLPRVRYDQLMKLGWKILMPVS
                     LAWILLVSTIKAFKNDGYDIQQILWITAGVIAVVLVVTVVWEMVRGGDGGEIVPGAEAP
                     APRDPFAGGFPVPPMDAPHYHGRAREEPARPATIESASEEVTSGTH"
     misc_feature    26979..26990
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
ORIGIN
        1 cggatcgtgg gtgaccatgg cgatgctctg cccctcccgg tcgaccatgg tccgcagcag
       61 gccgagcacg gtgcgggcgg acgcggagtc gagcgcgccg gtcggctcgt cggcgaacag
      121 gacggcgggc cgggtgacca tggcgcgggc gatcgcgacg cgctgctgct gcccgccgga
      181 cagttcgcgc ggccggtgtc ccagccggtc gcccaagccg accgagccca gcaccgcgcg
      241 cacgtcggcg cggcggacgc gggcgccggc gagcttgagc gggagcgcga cgttctgctc
      301 ggcggtgagc gagccgatga ggttgaagct ctggaagacg aagcccatgg tgcgccgccg
      361 cagcccggtc agcacccggt cgggcgcgcc ggtgatctcc tgccccgcga gcaggacccg
      421 gccccgcgtc acccggtcga gcccggcggc gcagtgcagc agggtggact taccggagcc
      481 ggacgggccc atcacggccg tccacgatcc ggtggggaag gcgatggaga cgccgtcgag
      541 ggcgcggacc agcgcgttgc cgctgccgta ctcgcgggtc gcgtccagca gctcggccgc
      601 ggggagcccc ggtgggacgc gggccgcgat cgggatgccg gatgtcggtg tgctggtcat
      661 gcgttcacgg aaccatccgg cccgggccct ccgcatgacg cccaaccagg atctttgaag
      721 tatggccagc cataccgtcc ggccgcgcgg gcttggctag cttgggttcc atgaccgtca
      781 ccgcgccccg cactggaggc cgcggcccgg cggcggttcc tgatctcggc ctggccctgg
      841 cgatgcgcgg gctacctgct gtcgacgtcg gtcccgatgc tcgcggctgc cgtcccgttc
      901 gggatgctgg tgctgccgtg ggccgccgcc ctgtcgtccc ggtacgggat cggcgcgcgc
      961 ctgctgctcg tggcgctggg cgtcctgttc gtcgccggtc tgggcccgct ggtggccttg
     1021 cccatcgccg aggtcgaacg ccgcaggctc cggttggtgg acgtccgccc catcgtctcg
     1081 gcccactcgc gtgtgaacgg ctccgagccg cgcacatggt cgctggtccg ttacggggaa
     1141 tccgccatct ggcgtgagat ggcctacgca tcactgttgg tgaccgtggt gcccgtcctg
     1201 tacgccgcgc tactgatgta tgtgttcacg atcgccggac tggccttcag cccacttctc
     1261 gctcagggcg acggcgaacc cgtggccctc ggtctggcca aggtggcgac tccaacggac
     1321 gccatcccgt acgcgttggc cgggctggct ctgctgccct ccatcccgta ccttgcggcg
     1381 gtcctcgcgg gcgcacacgg agccatggcc agaagcctcc tcggacgagg ctccggcgag
     1441 cgcctccgcg ccgaactcgt cgaggtgtcc cggtccaggg cgcggctggt ggacgcgttc
     1501 gaggcggagc ggcggcgcat cgaacgcgac ctgcacgacg gcgcgcagca acgcctgatc
     1561 ggcctcacgc tcaagctcgg catggcccgg gtggacctgc ccgccgactc cgatgccggc
     1621 cgcaacgtgt cggaggccca tgagcaggcc aagctcctca tggacgagtt gcgcgagctc
     1681 atccgcggca tccatccccg cgtgctgacc gacagggggc tgcccgcggc gctgcgcgaa
     1741 ctcgccgacc actccccggt ccccgtgacg gtcgagacgg acctgcccga acggctgccc
     1801 ccgcacgagg agggcaccgc ctacttcgtc gccgcggagg ccctgtccaa catcgccaag
     1861 cacagcggcg cccagaacgg ccagataagg gctcacctgc gcgacggaac cctggccttg
     1921 gaggtcgagg acgacggcaa gggcggcgcg aaccccgccc tagggagcgg acttaccgga
     1981 ctggccgacc gtgttgcggt gatcgacgga agaatgctcc tgtccagtcc ggccggtggg
     2041 ccgaccgtcc tacgcgtgga gttcccttgc agccgaccgt ccgagtagtc ctcgccgaag
     2101 acggcgtgct cctgcgggaa gggctcgtcg gcctgctcgg caagttcggt ttcgacgtgg
     2161 tcgccgcagt ggaggacgcc gacgccctca aggccgcggt agaggagcac gcccccgacc
     2221 tcgtggtgac ggacatccgc atgccgcccg gcttcagcga cgaggggctc cgcgccgcgg
     2281 tggaactgcg caaggcgcat cccggcctgg ccgtggtcgc gctcagccag tacgtcgagc
     2341 tgagctactc cgccgacctg ctcgactcca acggcggtac gagcgtcggc tacctgctca
     2401 aggaccgggt cgtcgacgtc gaggagttcg tcgccgcgct gcgccgggtc gtggacggcg
     2461 gtacggtcgt cgatcccacg gtcgtccggc agctcctgcg ccgcagccgg gatccgctgt
     2521 cgcggctgtc cgcgcgcgag cgcgaggtgc tggccctcat agcggagggg cactccaaca
     2581 cggccatcgc gcagatcctt accgtcgccg aggtgacggt gggcaagcac atcggcaaca
     2641 tcctcaccaa gctcgacctg ccgttgaccg acgacaagaa ccgccgcgtg ctcgccgtcc
     2701 tcacgtacct ccgcagccgc gcggccgcct agagcgtctt ctcgaaccgc acacggtcct
     2761 gccccgggcc gtcgtatccg ggtcttggtt cgtggacgtc gaagcccatg gcctggtgga
     2821 aggcgatgga gcccgtgttg gcgggcgacg tgatcgcctt gaccttcgtt aggccggccg
     2881 ccgcggcctc ctcgaagaac ctctcgtaca gcgcccgggc gatgccgccc ttacgccgcg
     2941 tggggtcgac ccccacgaaa tggatgtagg cctcgtccgg gtggtccgcg gaatggaatc
     3001 ccacgaggaa gccgtccatg ccgtcgtcgc cgtccatgac gaggctcgtc cctgagaagt
     3061 gctcgaagaa cagccggggc agcagcagcg tcagttgacg tgcctgctcc ggggtgcggg
     3121 agtccgccca ccaatccggc atggcccgca cgatcgcctc gtggtcttcc actcgcgctc
     3181 gtcggatgtt ccccaccgct ccgtccttcc accgtggaaa cgccgtttcc accatcctcc
     3241 ccgaccaggt gccgttccgc tctccaggca tccgtgcgcg gacgggcgcc gtacactgac
     3301 cagggagttc acggtcagga gagccatgcc cagggcggac gcgcagcgca accgcgacct
     3361 cattctcacg gcggccaaga aggtcttcac cgagcgcggc cctagcgcgc ccctcgacga
     3421 catcgcccgg cgcgcgggcg tgggcaacgc caccctgtac cggcatttcc ccacgcgccg
     3481 cgacctgctc gtcgccgtct actcggacga ggtcaccgac ctcaccaccc agggccggga
     3541 cctcctgcgc caggacccgc ctgcggatgc gctcttcacc tggctgcggg ccttcatcac
     3601 ccacgtcgcc gacaaggccg acctggcccg cgccattccg gaagacggac gctcgcccct
     3661 cttcgaccaa tggcacgcag ccatgcacac ggccctggcc cctctactag caagagccca
     3721 ggagaccggt gccgtccgcc ccgacctcga cggacgtgac ctcctggcac tggctggcgg
     3781 tatagcgacc gcaggatccg gcgccgctca gaccgaccgc ctactccgtc ttgtacgcga
     3841 aggcatcgcc acccccgcgc agaccccgaa ctgacccgta ccctgggtgg acgatcatgt
     3901 cctggccggg atggtgaaga ctgtccggca tggagttctt ctgctaccac cgtgacaggc
     3961 gcgactctct ggcactgcgc tacgaactct tggaagagca ctggtcctac atggacgggt
     4021 acgcggccga gatgatcgcc cgcggcccga ccttggctga ggacggcgaa acgcccaccg
     4081 gcagcgtcca catcgtcgac ctgcccgacg cctccgcggc gcgcgctttc gccttcgacg
     4141 agcccggcta ccaggccggc gcctaccgcg acgtcatgct gcgccgttgg cacaacacgc
     4201 tgggccgcac gatgtgggag ttcacaggcg accgcaccga gggcacccat tacctggtgc
     4261 tcggcctcgg cgcaggccac accgccgacc aggacgtgcc gcccgaccac cacacactga
     4321 tcgcctacgg ccccctgctg tccgacgacg gttccacctg gctgggcacc gccgcactgc
     4381 ttcacgcacc gaccccagag gccgcacgca ccgtcctgac cgcagaccgc tacgcggaga
     4441 tcgaagtcca tgactggacc ttcgggggcc gacgctagaa cacgaacaac gccgcaccgc
     4501 cctgctcgac gcgtcgtagg ccccttctgc agcctcacat ccgagctctc agcacgtcga
     4561 cctcacagcc gggcgcggac gggtcgaagc cgtgctcggc cagccagcga accgccagca
     4621 ggcttcgcaa cgaccaccac gcacggatca cgtcccgatc gacatcggcg ccatagccgg
     4681 cgatgacgtc gtcgaggcgc tcctcgtgcc cgagcgtcaa gatggcgagg tcgaacaggg
     4741 cgtcaccggg acccgcctcg gaccagtcga tgatgccggt gacctcgtca ccgtccacga
     4801 acacgtgcgt gatctgcaga tcgccgtgcg tgaagaccgg agtccacggc cggagcgccg
     4861 cctcggcgac ctggcggttg cgcatgacca ggtcggaagg caggacgtcg ctcgccagga
     4921 gccgctcgca ctcggcgtcg agttccgccg ccagctcgcc ggggccccgg ccgggccacg
     4981 gcggcaacgg cgcgtcgtgc aacgtccgga tggcggcgcc cgccgcggcc cacgccgccg
     5041 gcgacgcggt cgacggctcg ccgagacggc cgagcgccgt ccccgggacg gcggatatcg
     5101 cgagcaccgg cggcttgcgc cacaggacct tcggggtcgg gaccggcacg agtgccatcg
     5161 cctcgacctc gacgtcgata cgcgactgat cagcgtccac cttcaagaac acgtcgccga
     5221 cgcgcaaggt cgcgcgctcg gaatgggcga cgacgacctc gacctcatcc acggcggcca
     5281 gtatcgcccg cccgatcgcc acgccgatag tcccgagcga agacgacgag gtcccgcccg
     5341 cacgacatct gtttcagaac gcgcctacta ggaggcaccg aggcactctg tacacctcgg
     5401 ctagtccgct ggagaggcgg ttctccaggc agcggtctgg aactcgggcg gaacatcgtc
     5461 ctcgcccggg tcgatccccc gacgttcgag ggcgtcgaac caggcatcgc gctgggacgg
     5521 cggcaaccgg gtgccgcacc acggacagaa agcgatcgag atgacgctgc ccccgccgtc
     5581 atggacgata aggccgcact cgtcgaaccg cgcgctgtaa ctgacgagcg cgtccgggca
     5641 gtcagaagcc attcgggtct tttccgaagc actgcggatg atcacggtcc gttccatgaa
     5701 cggaccttac ggtgagcgtc accgaacgtg acatgttctc gtcgtctcct aacagaggtt
     5761 caccagcctg gcggtagttc gttgggacgg cgggtgtacc accaacggac ctctcggccg
     5821 tcggccagag gacgatggta atgcgacagc tcggcgccgc cgtcctcata ggtaaccgct
     5881 cggtagcggg cgtcgaggcg ccccacgcag cggtcggtct tggtccgcaa ggccgtcggc
     5941 atggcgtcga ggaactcctc aattccgctt ctgacggtga ggacgttcag gtactcgtac
     6001 accatgtagt aatcctggcg gcgccagcct tcctccatgc gggagatgag gatctcccag
     6061 aagcgcaggc agttgaggac gccgtaggtc ggggtggtgt cctggaagtc ccgaccggcg
     6121 ttctccgcgg ccagaacctg caggtcgagg agtgcgaccg cctgccggtc ctcgggggtg
     6181 agcgaacgga ccaggccgtt ggtctcgtcg gtgctcactc ggcgggggcg atgcctgtcg
     6241 ggcaggagag gccggtgccg ccgatgccgc agtagccgtt cgggttcttc tgcaggtact
     6301 gctggtggta gtcctcggcg tagtagaagt cggtggccgg ggttatgcag gtggtgatgg
     6361 ggccgtagcc ggcggcggtg aggacgggct ggtaggcgtc gcgggacgct tcggcggcct
     6421 tgagttggcc gtcggtgcgg gcgaagatcg cggagcggta ctgggagccg acgtcgttgc
     6481 cctgccgcat gccctgggtg gggtcgtggg cctcccagaa gacgcgcagg aggtcgtcgt
     6541 aggagacgcg cgacgggtcg tagacgacgc ggacggtctc ggtgtggccg gtcaggccgc
     6601 tgcacacctc ttcgtaggtg gggttcgggg tgtagccgcc ctcgtagccg gcggaggtcg
     6661 agacgacgcc gggggtctgc cagaacttgc gttcggcgcc ccagaagcag ccgagggcga
     6721 actcggcgac ctcggtgccg tcggggaacg ggggcgcgag gggggcgtcg aggacctcgt
     6781 ggcgcggcgg gaccgggatg ggctcgtccc tgcccgggag cgccttctcc ggagagacca
     6841 tccgggtctt cgcaaagccg aacatgtcct ccaggttagt gagcgttcga tcggttcggt
     6901 catgacgtgg ccgcggacgg gccgagtgaa agcggcgcat tgaaggcgat ccggttgagg
     6961 cactagagtg ccgcacgtca cattccggac acgaggagcc ccgttgcgtc tgctgagcgt
     7021 caccgtgctg gggaccgcgc tcgtcgcggc gggccttctg gcgccggcgg cgggcgaggc
     7081 gacgacatcg cagcaggacg ggctgacggt gcggccgggg acggtccgcg ccgggcagaa
     7141 ggtcgaactg tcggttcccg gctgcgggcc ggggcggcac cgggcctcgt cggacgcgtt
     7201 cgacgggcgg gccctgctgg acgactccga cggcaccgcg acgatcaagg acggcgtgcg
     7261 gccggacacg taccgcgttt cggtggactg cggccggcgg aaggtgaccg gaaaggtgcg
     7321 ggtcgccgga cggctcggct ggccggccct cctacccgac ctccgcaacg gccgctgatc
     7381 aggcgttctc ccagttcgga cggccgctcc gtccgccgtg cgacgcacgc ccgggacccc
     7441 gagccgcggg ggccctgtca agtcgtctcg acaaatgaga caacgcgtcc agcaagtgac
     7501 atacgtcacg cttcacaggt tgagatttct accggtccac cccttgagcg cggcaaatga
     7561 tcatgtgata cttccacaga agcgagcaaa aagaacaagt ctcacaaaga tgaacagaca
     7621 cccataactg cacattactc ctcgccatgc ggcacggcgc gagcgagccg cagggcactc
     7681 gccgcttaac tcctgaccta ggggcagccg agaatgtccg ttgacgtcgc cagcgttccc
     7741 gccgccaaag cgaagaactt ccccctttac cgcacggtca ccggcttcgt ccgcgacccg
     7801 ctccgggaac tggagcggat cagcaaggag tcggacggcc ggctcatccg gctggacctc
     7861 ggcgcttccc atccttacct cgccacacat ccggaccatg tgcagcaggt attgcggcgc
     7921 gaatcgcaga actttctgcg cgacggcatc ttctggcgtc ccctccgcga actgatgggc
     7981 gacagcatcc tttccgaggg cggggaatgg gagcacagca aacgggttct gcagcccgtt
     8041 ttcaccacgc gtaatgtgaa tcgcctcacc gggatgatgg cggaggccat caataccgcc
     8101 gtcggaaaac tggacgcgcc ggcccgcgaa ggccgcccca tcgacgtgct gcccgagatg
     8161 agccggatcg tcaacgagac cgtgatcaag gtcctgttcg gcgacaagat ctccccggtc
     8221 gaggcgaacc ggctgatccc gacgttcgac cagatcgcca cctcgatctc ggtccggttc
     8281 ctgctgccgt tcgtgccgcg cgcgctcccg atgcccggcg accgggcgtt caaggacgcc
     8341 gtccaggtga tggacgaggt gctgttcgag ctggtgaagc ggtaccgcga cgacccgggc
     8401 gacggcagcg acatcttcac cgcgctgtgc caggccccga ccgaggacgg cgcgccgccg
     8461 gacgaccggt ggatccgcga caacctgctc gccatgttcg ccacgagcac cgagaccacg
     8521 acgctggccc tgacgtggct gtggccgctg ctgcacgacc acccggacgt ggaggcgcgg
     8581 ctggtcgagg agatcgacgc ggtcgtcggc ggcgagccgg tccgccccga gcacctgcac
     8641 cggctgccgt acgtcacgca ggtcgtccag gaactgctgc ggctctaccc cgtcgggtgg
     8701 atgttcccgc gcatggccac cgaggcgacg accatcggcg gcgtcccgat caaaccgggc
     8761 gacccggtgc tgatcagccc gttcctcacg caccggctgg cgtcggtgtg ggaccggccg
     8821 ctggagttcg acccggagcg cttcaccccg gagaacatcc gcaagcggca ccgctacgcc
     8881 tatttcccgt tcggcggtgg accgcaccaa tgcatcggcc ggcacgtgtt caacgtggag
     8941 gcgcagatga tcctgaccag catcctcagc cggttccggc cgacgctgtc ggaggcggtc
     9001 cccgcgatgc ccaagatcgg cgcgacactg cggccgcggc agtcgctgga gatgacgctg
     9061 acgcccgtcg ccggacacgg agcgtgaccg cggcggacgg ggcggcctcg cggccgtccg
     9121 gcctcgcgcg cccggacgcc ctcgcggacg cgcgggagac cggggccgtc atggcccagg
     9181 ccgtgaagtg cgcccgcgac ctcgcggcgt gcgccgccga ccaccccggc ctgttcgacg
     9241 ccaagccgat cgacgagacc ctgttcaacg cggtggcctg cgcgaacgcg ttcgggtccc
     9301 cgtggctgga cgcggcgggc atccggatgg cggcgcgcac ctcgctgtgg atcttcggcc
     9361 tggactggct ggtggaccac gtcgcggcgg agcgcgccga gatcgaggac atcaaccggc
     9421 ggtgcctcgc ggtcgccgac ggcgccccgc cggtgccggg cgacggcctc acccagttcc
     9481 tcgccgagat cagggacgag gtcgcgcagt cgcccgcgtt cgcgagcctg cgcggcgact
     9541 ggcgggcgca gttgcgccgg ctgctggagt gcggggcccg cgaatgggac tggaagagcg
     9601 gcgaccgggc ggcgtggccg acgttcgacg agtacctcga caacgccgac aactacggct
     9661 cggcgtgggt caacgtctcg cactggatcg tgcacgcgga cgccggcgtg ctcgcccacg
     9721 ccggcgagct gcaggtggtg agccgggagg tgcagcgcat cctccggctg ctcaacgacc
     9781 tcgccaccta cgagcgcgac gtgacgtggg gcgacctgaa cgcgcagatg ctcggcgtgg
     9841 accgcgccac gatcaccgag cggatcggcc ggatcgtcga gcggtgcggt gagctcctcg
     9901 cgccgctgcg cgcggactgc ccggaggcgg tcgcctacct cgaacggcag atcggctaca
     9961 gcaccgggtt ctacgagctg agcgactact gggggtcgct gtgaccgtcg gggaggcgga
    10021 acccagtacg gccagcggcg aacctccccc ggcagaggtc gccgaggccg cgaacgcgct
    10081 cgtcggcggc ctggtcgagg ccccttgggg cacggcgtcc gcgtcggtgt acgagacggg
    10141 ccgggtggtg agcctcgcgc cgtggctgac cgggcacgtc cggcggctgc ggttcctgct
    10201 cgaccagcag cggccggacg gcggctgggg cccgcccgac gcggggtatt cgctggtccc
    10261 gacgttgagc gccaccgacg ccctgctctc cacgctggtt ccggagggac gggcgtgggc
    10321 ggacggcgcc gaccgcgccg aggtggcctc cgccgcagag cgggcgctgc gcctcctcgg
    10381 ggactggctg gacgaagacg ggactcccga cttcccggac atgccggcga tcgagcacat
    10441 caccccgtcc ctcatcgagg cgatcaacgg acggctggat cggctgcgtc cggcgccgtc
    10501 cggcgaccct gctttcggct ggtccgggcg gttgcgcccg cccgcgggga tggacggctc
    10561 gctgctgccg tccgtccgca agcacctcgc ggacggcggc gccgtgcccg tgaagctgct
    10621 gcacgcgctg gagatcgccg ggagttccgc gcacggcgcc gccgcggtgc gtcccgtgga
    10681 cgtgcccgcg cctcccggcg tcaccaagag cacgacgttc gcgacggtcg gcgcgtcggc
    10741 ggcggcgaca gcggcctggc tggggacgcg cggcgccgac ggcggcggcg accccgacgg
    10801 cgccgcgcgc cgctatctgg aggcggccgc cgggcagtgg ggcggtcccg ttccggtggc
    10861 gacgccgatc acgaatttcg agcggggttg ggtgctcggc tggctggcgc gcgccggaat
    10921 tccgttcgcg gtgccgcccc ggctcatcgc ggagatgcgc gcctcgctcg gcgaggacgg
    10981 cgcgcccggc ggcccgggac ttcctccgga cgccgatacg agttcgggtg tgctgtacgc
    11041 gttgtcgctg ctgaacgagc ccgttccgcc cgatctgctc tggcggtacg aagcgggcgc
    11101 gcatttctcc agctggcccg gggaggacgg ccggtcggtg acgacgaacg cgcacgtcct
    11161 tgaggcgttc ggccattttg cgcggtcggt cgggcccggc ccctcgggac gttatgcggc
    11221 gaccgtcagg aaagtggcgt actggctcgc cgaccagcag ggcgacgagg gatcctggac
    11281 ggaccggtgg cacgcgtcgc cgctgtacgc gaccgcctgc tgcgcgctgg cgctggacgc
    11341 gttcggcgga ccggacgccg ttccggccgt ggaccgcgcc gtccggtggg tgatccggga
    11401 acagcgtgcg gacggctcct ggggccgctg ggacgggacc gcggaggaga ccgcgtacgc
    11461 cgtccagatc ctgtgcctca cccgggcggc cgccggcgag cggccgggag tgccggccgg
    11521 ggacgcggtc gcggcggtcc ggcgcggcga cgaccacctc cgagcggcgg tccggcgcag
    11581 gtcagagggc ctgcgcgggc cggggccgga gggcgtgcgc gggcgggtgg ccgacatcga
    11641 ctccggcaag catccgcttt ggcacgataa agacctatat cgcccaatta cgatcgtgca
    11701 ggcggcggtc ctgggcgccc ttcacctcgc ccgaagcgac gcccgtgttt cacgccggtg
    11761 aatttcccca cacctcgccc atcgccgccc tggcgagaag tcacagggta aaccattcac
    11821 cttgagcagg tttggtggcg ttggtaaggt tcaccggtgc gctgaccgat acccggcata
    11881 gcgccgaccg cacaaaccgc caccgggtgt cccgcagcca ggcccagcac ctcgcattgc
    11941 aggcaccttg acaattgttg gggcgatcag aatgcgtttc cgcaactccc gactgcggac
    12001 caagattgcg gccctgctgc tctcgctgac ggcgctgtgg gtcttcgcgg cctgggtgac
    12061 gttgcgcgaa ggcgtgaacc tgctgttcgt caacacgctg gacagcgtgg tggcgccgag
    12121 cgacccgctg ctcgtcgacc tgcagcagga gcgccgtctc acggtgacca tgctcgcctc
    12181 cggccggctc agtcccgacc agctcgccgc cgcgcgcgcc cggaccgaca aggaccggga
    12241 gatcgtcgtg cggaaggccc gcagcggtgc ggtccggcgc gcggccgacg gcagcatgga
    12301 caagcggctg gagcagatgg tcgaccagct cgcctccctc gaccaggaac gccgctcgat
    12361 cgacgccggc gccttcgacc ggcaccgggc cgtccaggcc tactcggacg tcatcgagtc
    12421 gatcttccac atgtacgacg gcacgaccac gctcgacgac cggggcttca ccaccgccct
    12481 gcgcgcggag atcgccgtca accggtcgtg ggagctgctc tcccaggagg acgcgatcgt
    12541 cgccggcgtg ctggcgaccg gccgcatcac cgtcgccgac cggatcgaca tcgcgcaggc
    12601 catcggcgcc cgccggctca actactcgcg cgccatgatc gacctggagc ccgccgaccg
    12661 ccaggcgtgg aacgagctga acaccgacaa gcggctcgcc accgtccgcg ccatggagga
    12721 cgtcctcctc cagcagcgga ccaggacgat ggtcccccgg atcagcgccg accagtggcg
    12781 cgccgccacg acgccggcgc tggcgcagat gcgcacgtcc atccaggacg ccggtgaccg
    12841 gctggtcgag cgggccaccc cgatcgcggc ctgggtcatc gtccggctgg tgctggccgg
    12901 tggtctcggg ctgctggcgg tcatcgcgtc gatcgtcgtg tccatcacca cggcccgcgc
    12961 cctggtgcgg cagctggaac ggctgcgcac cgccgcgtgg gagctggccg agcagcggct
    13021 gcccggcgtc gtcgagcggc tcgggcacgg cgagaaggtg gacgtctcgg tggaggcccc
    13081 gccgctgcag ttcggcaccg acgagatcgg gcaggtggga cgcgcgttca acgccgtcca
    13141 ggagaccgcg atccgcaccg ccgtcgagca ggccgagctg cgccgcggca tccgcgacgt
    13201 cctgctcagc ctggcccgcc gcacgcagac cctcgtgcac cggcagctga ccatgctgga
    13261 caccatggag cgccgccgcg acatcgaggt gaaggagctg gaggagctgt tccggctcga
    13321 ccacctcgcc acccggatgc ggcgcaacgc cgagaacctc atcgtgctgt cgggcgcgct
    13381 gcccgcccgc gggtggcgca gctcggtgcc gatgatcgac gtcgtgcgcg ccgcggtcgg
    13441 cgaggtcgag gactacaccc gcgtcaccgt gctgccgttc ggcccggtcg agctggcggg
    13501 gcgggcggtc ggcgacgtca cccacctgct cgccgagctg atcgagaacg ccgtgtcgtt
    13561 ctccccgccg gacacggtcg tgcaggtcgg cgggcacctg gtcgccaacg gcttcgccat
    13621 cgacatcgag gaccgcgggc tcggcatgac cgacgagaag ctcgccgaga tcaacgcccg
    13681 gatcgaggac ccgccggact tcaacctgca gagctcggtg cagctcggcc tgttcgtggt
    13741 cagcaggctc gccgagcggt acgggctgcg ggtctcgctg aagcggtccg cctacggcgg
    13801 caccaccgcg gtcgtcgtcg tcccgaccga gctcgtcgtc gaggagagcg accgggtgcg
    13861 ggccccggcg gccacgacca cgcagaacgg cctggaggtg cggcagccga ccgccgtcgg
    13921 cgcccgttcc ggcggccccg cggccctcac caccggcggc accgggccgc agccggcgcc
    13981 gtccgcgccc gcgctggtgg ccgtgccgcc gcccgcgccg gaaccgggcg agacgccggt
    14041 cccgccgtcc gggcagggcc cgaacggctc ccctgaacgc ggcctgcccc gacggcagga
    14101 cgagcccccc gcgggcggag cgcgctccca cgacggcgcc ccgtccacac cgcccggtca
    14161 caccggcgcc ggcggcgggc atcccgaacc gacccagccg gaggacctgc cccccgtgcc
    14221 cgacatctcc accaccccgt ccggcctgcc cgtccgcgtg ccgcaggcga acctcgccga
    14281 accactgcgc acggacgagc cgatcgtggc ggaagaaccg gatgaaacgg acgacccggg
    14341 ccgctctccc gaggagatcc agcggatcat gggctcctac cagcgcggca cccggcgcgg
    14401 ccggtcggac gcggccgagg ccctcggcaa cgaagcagcg gaaggcgagg aaggtcagtg
    14461 acgcagaaga ccggttcttc atcggacctc ggtttcttgc tggacgacct ggtccaccgg
    14521 ttgccgcacg cgcgcaacgc ggtggtgctg tccgccgacg gcctgctgat ggcctcgtcg
    14581 gcgggcatga cccaggacga cggcgagcac ctgtccgcgg tggcggcggg catccagagc
    14641 ctcgccaagg gcgcgggcac ccggttcggc ggcggccccg tccggcagac gatcgtcgag
    14701 atgcagtcgg cgttcctgct ggtgtccgtc gccggcaagg gcgcctgcct ggcggtgctc
    14761 gccggcgagg aggccgacgt cggcctcatc gcctacgaga tggcgatgct cgtcaccagc
    14821 atgggccacc acctcaccac gccgtcgcgg tcggaggccg cggaggaggg gcgcccggca
    14881 tgatgccgcc cgaggaaccg ggacaggaac cctggccgca ggatcccgcg ctgcacaccc
    14941 ccggccacga acgcgtctac gacgagagcg ccgggcccat ggtgcgcccg tacgtgatga
    15001 cgagcggccg catcgaaccc gtccacggca agttcgacct catcaccctg gtggtggcgg
    15061 ccgggccgga gccggagggc gcgatcggcc tcggccccga gcacctggcg atcatccagc
    15121 tctgccggca ggtgatgtcg gtcgccgaac tgaccggcca cctcgacctc ccggtggcga
    15181 ccgtgcgggt gctgctcggc gacctgctcg gcaaggggct cgtcacgttg caggagcccg
    15241 aaccggaggc ggacatgcac gacatcaggc tctacaaggc ggtgatcgat ggactccggg
    15301 ccctctaacg ccgtgggcgc gcggcacgac gcgcgcgccc gccggatgcc caccgcggtc
    15361 aagatcgtga tcgcgggcgg tttcggggtc ggcaagacga cgatggtcgg caccgtctcc
    15421 gagacgcggc cgctgcgcac cgaggagatc ctcaccgacg agagcgtcgg cgtcgacgac
    15481 atctccggag tcgagcgcaa gaagaccacc acggtcgcga tggacttcgg ccggctcacc
    15541 ttccgcgacg agtacgtcct ctacctgttc ggcacgcccg ggcaggagcg gttctggttc
    15601 atgtgggacg aggtgtcgct cggcgcgctc ggcgccgtgg tcctcgccga cacgcgccgg
    15661 ctgtcggact gcttcccgtc cgtcgactac ttcgagcggc gcggcacgcc gttcgtcgtg
    15721 gccgtcaact gcttcgaggg cgccaagcag tacgacctcg cggagatcca gctggcgctg
    15781 aacctgggcc cgaaggtccc ggtgatgctc tgcgacgccc gccgcctcga ctcctgcaag
    15841 caggtgctca tcgacctcgt cctgcacgcg atgaagtacc gcgggctccc ggcgctggag
    15901 acgcagggcg cctagccgcg cgggccgcgg gggcgccgcc ggtgcggcgc ccccgcggac
    15961 ccgaaggccc ccggacacga gtaagccccc gccgcggcgg gggctttccg gttcgtgcag
    16021 ggggtcagcc ggtccgcgag acgacgaagt cgcagaggcc ggtgaaggcg tcgcgggcgg
    16081 ggatggcggg gagggtcagc agctccgccc gggcgtcctc cgcgcactgg cgcaggtcgg
    16141 cgcgggcgag gtccatggcg gggtgggcgc gcagcagcgc gagcgcctcg gcgtgcagct
    16201 cgtcgccgga caggtcctgg acgagcagct cgcgcagccg ggcgtcgtcc gggccggagc
    16261 cgacgcccgc gaggacgtgg tgcatcggga gggtgcggat gccctcgcgc aggtcggtgc
    16321 cgggggtctt gccggactcc tcggtctcgg agtcgatgtc gaggatgtcg tccgacagct
    16381 ggaacgcgac gccgatcttc tcgcaggcgg aggtgatggt gtcgacgacg tgcgcggggg
    16441 cgcccgacag cagcgagccg aactggccgg acaccgcgat cagcgaggcc gtcttgtccg
    16501 cggcgacctg caggtagtgc ttgagggggt cggcgccctc ggcggggccg acggtctcct
    16561 ggatctggcc gcgcaccagc cgggcgaacg cgcgggcctg gatccggacg gcctcgggac
    16621 cgaggtcggc gagcaggtcg gacgcgcggg cgaacaggta gtcgccggtg aggatcgcga
    16681 cggtgttggt ccaccgcgag ttcgccgacg cctggccccg ccggacggtc gcctcgtcca
    16741 tgacgtcgtc gtggtacagg gtgccgaggt gggtcagctc gacgacgacg gcggcgggca
    16801 ccaccccggc cgcggcgggg tccccgaagt gcgaggcgag cagcaccagc atcggccgga
    16861 agcgcttgcc gccggcctcg acgaggtgct tggacgcctg gctgagcagc gggtcctcgc
    16921 cccgcaccga ctccagtagc agttcctcga ctgcggccag gcgctgcctg gcgtcggccg
    16981 cgagggccga gtcgacggga agcccgaacg ggccggactc ctgtcgagcc ggcccgccgg
    17041 acttctcagc gattgggtcg ctcacccaag actccctacc ggacgaacat gtgggtcgtg
    17101 gcgtggcccg ccaggtccag aacgggctgc gggatcacgc cgagtaccac agtagccgtc
    17161 gccccgagcg ccaccgcagc cgcggtcgcc ggcccggcga cgacgacggg gccgtccgcc
    17221 tccggctcgc tgaagaacat cacgacgatc accttcacgt agaagaaggc ggccaccgcg
    17281 gaggagatga cgccgaccac gaccagcggg gtcgcgccgc tctcgacggc ggccttgaac
    17341 accgcgaact tgccggtgaa gccgctggtc agcgggatgc cggcgaaggc gagcaggaag
    17401 aaggagaaca ccccggcgac gaccggggag cgcttgccga gccccgccca gcgcgacagg
    17461 tgcccggcct cgccgccggc gtcgcgcacc atcgtgacga ccgcgaaggc gccgatggag
    17521 gtgaagccgt aggcgacgag gtagaacatc gtgctggaca ggccgtcgcg ggacgtcgcg
    17581 acgacgccca tgagcaggaa gcccgcgtgc gcgatggacg agtacgccag catccgcttg
    17641 atgtcggact gcgtgatcgc gatgatcgcg ccgaccacca tcgtgagaat cgccacgccc
    17701 cacatgtagg gccgccagtc ccacttcagc gtctcgaacg cgacgtagta gacgcggagg
    17761 atcccgccga acgcggcgac gaccgtgcac gaggccatca gcgcggtgat gggggtcggg
    17821 gcgccctggt agacgtccgg cttccacatg tggaagggga cgccgccgag cttgaacagc
    17881 agcccgaccg acagcagcgc gacgcccgcc agcagcaggg tctcgctgcc ggcgtccttg
    17941 ctgacctgcg cggagatgtc cgacagccgg accgagccgg cgtagccgta cagcagcgcc
    18001 gtcccgtaca ggaagaacgc cgaggagaac gcgccgagca ggaagtactt gacggccgcc
    18061 tcctgggaga gcagccgccg ccggcgggcg agcccgcaca gcaggtacag cggcagggac
    18121 atgacctcca gcgccacgaa catggtcagc aggtcgttgg cggcggggaa catcatcatg
    18181 cccgcgaccg cgaacatcat cagcgggaac acctcggtct gggtgatccc ggccgcggtg
    18241 gtgcgctgct cgtcctcgct gcccggcagg gcggacgcct gcgcggcgaa gtggccgccg
    18301 acgatgccgc cgctgcggcc gttgccgcgc tcggcgatca gcagcaggct gacgagggcg
    18361 aggacgagga cggtgccctg gatgaacagg gtggggccgt ccacgccgag ggcgccctgc
    18421 gcggcgacgt ggtgcgggtt gtcgcgccag ccgagcagga ccgtccacac gaacgcgccg
    18481 gcgaggccga ggaaggcgac cgggacctgc accgcgtacc gccaggtgcg gccgacgaac
    18541 gcctcggcga ggacgcccgc gacggcgatg ccgaggacga gcagcagcgg gccgatctgc
    18601 ccgtactcga tgtgcggcgc cgggatgtca cccccctggg cgagcacccc atgagccatc
    18661 accgggctca cgtgactggc agggctcatg gacgggctcc gttctcggcg acgttaccgg
    18721 tgagcgtcgg cgccgggtcg tgccggtcga cacgggcgag cgtctccttc accgacgggt
    18781 tgatcacatg cagcaccggc tgcgggaaga agcccatcgc cacgatgatc gcgatgatcg
    18841 gggcgacggc ccacttctcg cgggccgtga ggtccttcat gccctcgacg gccgggacct
    18901 tcgggccgcc catcgtccgc tggtacatcc acaggacgta gatggcggcg agcacgacgc
    18961 cggtgacggc gaagcacgcg gccaccttgt agcggctgaa cgtgccgacc agcaccagga
    19021 actccgacac gaacggcgac aggccgggca gcgacagccc ggacaggccg gcgatgagga
    19081 acgtcccggc gagcaccggc gcggccttct gcaccccgcc gaagtcggtg atcttcgccg
    19141 accggcgccg gacgatcatg aagccgacga gcaggaacag cgcgccggtg gagaagccgt
    19201 ggttcaccat gtacagcgcg gcgccggact ggccctgcga ggtcatcgcg aagatgccga
    19261 gcacgatgaa cccgaagtgc gacaccgagg tgtaggcgat gagccgcttc aggtcgacct
    19321 gcccgatcgc gaggatcgcg ccgtagatga tgctgatcac cgcgaacacg agcaccgcgg
    19381 gcgtcgccca cttggacgcg ccggggaaca gctccaggca gaaccgcagc atcccgtagg
    19441 tgccgacctt gtcgagcacg ccgacgatca ggacgagcgc gccgggcggc gactgctgcg
    19501 ccgcggtcgg cagccaggtg tgcaccggca ccatcggcgc cttgatcgcg aacgcgatga
    19561 agaagccgag gaacagccac ttggcggtgg tcgggtcgac gtgcagcccg cgcagctcct
    19621 ggaacatgaa ggtgccgtgg ccgaggccgc cctcggcgac cggcttgttc gacagcgggt
    19681 acagccagat gaccgagacg agcatcagca gcccgccgaa cagcgagtac agcaggaact
    19741 tcaccgcggc gtaggagcgc tcgcgggcgg cgccgccgcc gtagtgcccg atgatgaagt
    19801 acaccgggat gagcatcgcc tcgaagaaga cgtagaacag gaacacgtcg gtcgccgcga
    19861 acacgccgat catcgcggcc tcgagggaca gcagcagcgc gaagtaggtc ttcaccgacc
    19921 gcttcgccgg gacgtccacg ccgccggacc gctcgtcctc gttccaggac gccagcatga
    19981 cgagcgggac gaggatgacc gacagcagga tcagcaccag cgcgacgccg tcgacgccga
    20041 gcgcccagtg gatcccgaac tccttgatcc accagtactt ctcggtgaac tggaaccggt
    20101 cgccgccggc gtcgaagccg gccgccatgg cgagggcgag cacgcccacg agcgtggaga
    20161 cgccgaacga gaaccacttg acgagcggct cgttgtcgcg cggcagcacg ctgaccgcga
    20221 cggcgcccag cagcggcagc gcgatgagga cgctcagcca gggaaagtca ctcatgacac
    20281 gttcaccacc aggagggcgg ccaccacaag ggctgcgccg aagaacatcg agagtgcgta
    20341 ggaacgggcg aagccggtct ggatgcggcg gaaccggccg gacgtgccgc cgatgagggc
    20401 ggcgagcccg ttgacggcgc cgtcgacgcc gcgtccgtcg aaccagaccg cgagccgggt
    20461 cagccactgg ccgggccgca tcagcagcga ctcgttgatg gcgtcgccgt acaggtcctt
    20521 gcgggccgcg acggtgacga aggagccggc gggcgcctcg cgcggcacgg gacggcgccc
    20581 gtactgcatc cacgcgatcg cgaacccgat caccatcagg acgaggacca cgatgcccgg
    20641 gagcgtgacc cacttgaacg actcggcgtg ctccggcttg ccggtgacgg gctccaggaa
    20701 gtcggagaac ccgccgagga tcagccatcc gccggcgaag acggagccga ccgcgaggag
    20761 catcagcggg atggtcatca ccttgggcga ctcgtgcggg tgcacgccct cctcccagcg
    20821 cttctcgccg aagaaggtca tgatcatcac gcgcgacatg tagtacgcgg tgatgcccgc
    20881 gccgatgacg gcgcagacgc cgaggatcgc gccggacgtg ccgcccttgt cgaacgcggc
    20941 ctcgatgatg gcgtccttgg tgaaccagcc ggacaggaac gggaacccga tgatggcgag
    21001 gaacccgagc ccgaacgtca cgtacgtcgc catcatgacg ccgcgcagcg cgccgtagtg
    21061 gcgcatgttc acgtcgtcgt tggtgccgtg catgaccgag ccggcgccga ggaacaggcc
    21121 cgccttgaag aagccgtgcg cgatgaggtg cgcgatggcg aacacgtagc cgggccggcc
    21181 gaggccggcg gcgagcgtca tgtagccgat ctgcgacatc gtcgacccgg cgagggcctt
    21241 cttgatgtcg tccttcccgc aaccgatgat cgcaccggcg agcagcgtgg ccgcgccgac
    21301 gatcgtcacc accagctgcg cggtctccga catctcgaag atcggcccgg accggacgat
    21361 caggtagacg cccgcggtca ccatcgtcgc cgcgtggatg agcgccgaca ccggggtcgg
    21421 gccctccatc gcgtcgagca gccaggactg cagcgggagc tgcgccgact tgccgcacgc
    21481 gccgagcagg agcagcagcc cgatcgcggt cgcggtgccg gtgctcagct tggcggcgag
    21541 cccggcgtgc tcggcgcccg cgccgaggat cggcccgaag tcgaccgtgc cgaaggtgga
    21601 gaacatcagc gcgatcgcga tgatcagccc catgtcgccg acgcggttga cgacgaacgc
    21661 cttcttcgcc gcggtcgccg cggtcggctt gtgctgccag aacccgatca gcaggtacga
    21721 ggcgaggccc acgccctccc agccgaggaa cagcacgagg aagttgccgc cgaggaccag
    21781 cagcagcatc gccgcgacga acaggttcag gtaggcgaag aaccggcgcc ggtcggggtc
    21841 ctcggccatg tagccgacgg agtagatgtg gatgagcgag cccaccccgg tgatcagcag
    21901 cacgaagctg atggacagcg ggtccaccag caggtccatg ccgatcttga atccgccgac
    21961 gttgatgaag tcccacaggt gcacggtgcg gcgccgcgcg gcgtcgtcgt acccgagcat
    22021 ctggacgagc atcgcgatgc cgatggcgaa cgacgccacc ggcgtcgcca ccccgagcag
    22081 gtgcccccac ttgtcggtgc gccggcctcc gagcagcagg atcgcggcgc ccaccagggg
    22141 cagcgcgatg agaagccagg acgcggcctg gatgccttcc gctttcatcc ctggcctctc
    22201 agtacttcag caggttcgcg tcgtccaccg acgaggacct gcgggtccgg aagatggtca
    22261 tgatgatcgc caggccgacc acgacctccg ccgccgccac caccatcacg aagaacgcga
    22321 tgatctggcc gtcgagggtg ccgtgcatgc gggagaacgt gacgaacgcg aggttcgtgg
    22381 cgttcagcat cagctcgacg cacatgaaca ccacgatcgc gttgcggcgc acgaggacgc
    22441 ccagaccgcc gatggtgaac aggatcgccg agagcgccag gtagtgcccc ggactcattg
    22501 accagcctcg ccttcacgct cgttgccgcc cgcgccgccg cccgcgtccc cgccggcggc
    22561 cggcgtgccg gccctgacga cgcgcgactc ggcgtcggcg tccttcgcct cttcggtggc
    22621 ggccttcacc gcggcgatgt cctcgtccat cgcgccctgc tcggtcccgc cgtacaggtc
    22681 ggcgtgccgc tcggcggtgt cggtgcgcgc cgcgatgacc gggttgatcg acagctccga
    22741 cggcgtcccg tccggcagca gcgccggcat gtcgacggcg ttgtgccggg cgtaggtgcc
    22801 ggggccgggc agcggcccgg ggtgctcacc ggaggcgaac cgccgcttgg acaggtcctt
    22861 ctgcgtcggc ttcggctcgg tccgctcgcg gtgcgccagc accatcgcgc ccagcgccgc
    22921 ggtgatcagc agcgcgctgg tcgcctcgaa cgcgaacacg tacttggtga acagcagccg
    22981 cgcgaggccg aggacgttgc cgtcggcgtt ggcggccttc agcccggcgg agtcgccgag
    23041 cgcggcgttg ccgagcccgg tgccgagcag cacgatgaag ccgatcgcga cgatgaccgc
    23101 ccagaaccgc tggcccttga tcgtctccac cagggagtcg gtggaggtga cgccgacgag
    23161 catcagcacg aacaggaaca gcatcagcac ggcgccggtg tagacgatca cctggacgaa
    23221 cgccaggaac ggcgcgttct ggatcgcgta catcgcggcg aggcagagca tcacggtcgc
    23281 cagcagcagc gccgagtgca ccgccttgcg cacgaggatc atgccgagcg cggcgcagac
    23341 cgacacgacg gcgagcagcc agaagaagaa cggctcgccc gactgcttgt cggcaacgtg
    23401 cccggccagc acgtgcgcgg cggccaggtg gtcggcggag agcggggcgc tcacttgccc
    23461 tcaccgccct tgcccgcctt ctcccgcttc accgcgttgt cggcgctcgc gcgtccgccg
    23521 ccctcggacg ggacggtcgg cgcggcgtcc tccggctgga ggccgaggcg gtagtagtcc
    23581 tcctcggtgt cgccgagccg catctcgtgc ggcggcgcct ccatgccctc gcgcagcggc
    23641 gcgagcagca tgtccttggt gtagatcagg ctctcgcggc tgtcgtcggc gagctcgtac
    23701 tcgttggtca tcgtcagcgc ccgcgtcggg cacgcctcga tgcacaggcc gcacaggatg
    23761 caccgcagat agttgatctg gtaggtgcgg ccgtaccgct cgccgggcga gtaccgctcg
    23821 tcctcggtgt tgtcggcgcc ctcgacgaag atcgcgtcgg cggggcaggc ccaggcgcac
    23881 agctcgcagc cgacgcactt ctccagcccg tccggccacc ggttgagctg gtgccgcccg
    23941 tggaagcgcg gggcggtcgg cttcttcacc tcggggtact gaacggtctc gctcttcatg
    24001 aacatctggt ggaacgagac cccgaacccc ttgaccggat tcaggaaatc agtgagtccc
    24061 actggtgacc tcctcagagg cggattcgat cgtggccggg cgggccggct cctcgcgggc
    24121 ccggccgtgg tagtggggag cgtccatcgg cggcaccggg aacccgccgg cgaacgggtc
    24181 ccggggagcg ggcgcctcgg cgcccgggac gatctcgccg ccgtcgccgc cgcggaccat
    24241 ctcccagacc accgtcacca ccagcaccac ggcgatgacc ccggcggtga tccacaggat
    24301 ctgctggatg tcgtagccgt cgttcttgaa cgccttgatg gtggacacca gcaggatcca
    24361 ggccagcgac accggcatca ggatcttcca gccgagcttc atcagctggt cgtagcgcac
    24421 ccgcggcagc gagccgcgca gccagatgaa gaagaagatg aacagccaga gcttgatcat
    24481 gaaccacagc accggccacc agccggagtt ggcgcccgcc cagaccgtgg agatcggcgc
    24541 gggcgcgcgc cagccgccga ggaacagcgt ggtggcgagg gccgacagcg tcgccaggtt
    24601 gatgtactcg gcgaggaaga acatcgcgaa cttcagcgac gagtactcgg tgtggaagcc
    24661 gccgaccagc tcgccctcgc cctcgggcag gtcgaacggg atgcggttcg actcgcccat
    24721 catcgtgatc acgtagacca cgaacgacgg ggcgagcagc accgcgaacc agatgtggtc
    24781 ctgcttggcg acgatctccg aggtggacat cgacccggcg aacatgaaca ccgcgacgaa
    24841 cgacagcccc atcgcgatct cgtaggagat catctgcgcg gacgagcgga gcccgccgag
    24901 cagcgagtac ggcgacatcg acgaccagcc ggccagcacg accccgtaga tgcccatcga
    24961 cgacatcgcc agcacgagca gcaccgcgac cggcaggtcg gtgccctgca gcgcggtgtg
    25021 gtgcccgaag accgacaccg tcgggccgaa cgggatgatg atgaacgaga tgaacgccgg
    25081 caccgccgac atcaccggcg cgaggacgaa cacgaccttg tccacctggc gggggacgat
    25141 gtcctccttc agcgccagct tcacaccgtc ggcaaggccc tgcagcagcc cgaacgggcc
    25201 gcagcggttc gggccgacgc gcagctgcat ccggccgatg acccgccgct cgacccacat
    25261 cgacagcagg acggtcagca ccaggaagac gaagatgacc agcaccttgc cgccgatcag
    25321 ccaccacggg tccttgccga acgtggcgag cgtgggatcg gcggcgggcg ccgcaagcgg
    25381 actcatcggg tacctcccgc gttctcggtc gggcgggcga gcacgccgct cgcgatcttg
    25441 acgacgccgc ccgccgccgc gcccaggtcc cggtggaggg cgcagcccgc cgagttcgtc
    25501 ggcagccaca ccacccggtc gggcaggtcg gcggtgatct ccagcgggag cgtcacctca
    25561 ccgcgcggcc ccgacaccgt gaccgccgcg accgcgccga tctccgccgc ggtcgcgggc
    25621 gacagccggg ccgccgcggc cttggcggtg cccgcgagga acggctcgcc gtcctgcagc
    25681 cggccgcggt cgagcagcag ccgccaggtc gcgagcagcg cctcgccctg ctcggggtgc
    25741 ggcggcagcg cctgcgcgac gtccggcggc tcgggccgct cgccgcggtg ggcgccgagc
    25801 tgcgcgagct cccggcgcgc cgcctccggg cccgggagcc cgaggtggac gtccatctcg
    25861 tcggccaggg actgcaggac ccgcaggtcc gacatcctcc cggcggactt cagcacgacg
    25921 tcgaacgggc ggccgcggcc ctcccagtcg acgaacgtgc cggccttctc ggcgacggcc
    25981 gcgacgggca gcaccacgtc ggcgcggtcg gtgaccgcgc tcggccgctg ctccaggctc
    26041 accacgaagg gcgcggcgtc cagtgcccgc agcgccgcat cggggtcggg caggtcgtag
    26101 gggtcgacgc cgccgacgag cagcgcgccg agccgtccct ccgccgccgc cgcgatgatg
    26161 ccggcggtgt cctcgccggg accggcgggc aggtccgcga cgccccaggc gcgcgcgacc
    26221 tcggcccgcg cctccgggtc ggcgacgggg cggccgatcg gcagcagccc gggcagcgcc
    26281 ccggcctcga tcgcgccgcg ctccccggcc cggcgcggca cccacgccag ccgggccccg
    26341 gtcacctgcg ccagccggac cgccgaggtc agcgccccgg ggctggtcgc gagccgctcg
    26401 cccagcatga tgacggcgcc gggcgtctcc agcagcgtgc ggacgccggc tcgggacggg
    26461 tcgccgatca gcgagccgag cgtctccgac tccgagccgg gcgacgtcgg cagcagcgtc
    26521 ccgccgacct tgctcaggcc gcgggtcgcg aacggggcga tcccgaacac cttcagcccg
    26581 ttcttgcgga acgccttgcg cagccgcagg aacacgatcg gggactcctc ctccggctcg
    26641 aagccggcga ggacgaccac gggcgccttc tccaggtcgg cgtaggacac ctcgatcggg
    26701 cggcccgcga ccgacgaggc gaggaaccgc gactcctcgt ccgacagcgg ccgggcccgg
    26761 aagtcgacgt cgttggtgtg cagcgcgatc cgcgcgaact tggcgtaggc gtaggcgtcc
    26821 tcgagggtga cgcgcccgcc ggtcagcacg cccgccgagc cgcgcgccgc cgcgaggccg
    26881 cgggcggcga cggtcagcgc ctccggccag gacgccgcct ccagctcgcc gttctcattg
    26941 cggatcagcg ggtgcgcgag ccgctccggg tgcgtcccgt aggtgaacgc ccagcggccc
    27001 ttgtcgcagt tccactcctc gttgacctgc gggtcgtccc cggccagccg gcg
//
