LOCUS       NZ_CP053892            22518 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4588107
            Orig. end                         :: 4610625
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..22518
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="14"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22518
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22518
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12518](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12518)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            128..574
                     /locus_tag="ACTIVE_RS19670"
                     /old_locus_tag="ACTIVE_3933"
     CDS             128..574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591652.1"
                     /locus_tag="ACTIVE_RS19670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3933"
                     /product="VOC family protein"
                     /protein_id="WP_246342971.1"
                     /transl_table=11
                     /translation="MSFYHVCFTVPDLAAAMRDLTAAAGLAWRDPAGGRLGEWDYRIVF
                     SAGGAPFVELIEAAPGGPWGDTSRPGFHHLGFWTSDLAAGTARLTDEGFAGTFSGCPYG
                     RAFAYHRVDSIGANVELVDQGLQASFLDAWNPGGPPMPAIDEPG"
     gene            complement(605..1303)
                     /locus_tag="ACTIVE_RS19675"
                     /old_locus_tag="ACTIVE_3934"
                     /pseudo=""
     CDS             complement(605..1303)
                     /NRPS_PKS="Domain: PKS_KR (6-121). E-value: 3.9e-09. Score:
                     28.6. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS19675_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012334.4"
                     /locus_tag="ACTIVE_RS19675"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3934"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTMAGKTVLITGATSGIGAHTARLLLDRGHRVAVTGRDESRLKTF
                     LDEVGRPDRLLGMVADAADWEATESAVARTVECFGGLDGAVANAGFMTGDSIGAGDPAS
                     WAPMVLTNVLGPALLAHAALPHL"
     aSDomain        complement(941..1285)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS19675_PKS_KR.1"
                     /evalue="3.90E-09"
                     /label="ACTIVE_RS19675_PKS_KR.1"
                     /locus_tag="ACTIVE_RS19675"
                     /protein_end="121"
                     /protein_start="6"
                     /score="28.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TVLITGATSGIGAHTARLLLDRGHRVAVTGRDESRLKTFLDEVGR
                     PDRLLGMVADAADWEATESAVARTVECFGGLDGAVANAGFMTGDSIGAGDPASWAPMVL
                     TNVLGPALLAH"
     CDS_motif       complement(1193..1285)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS19675_0001"
                     /evalue="2.30E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="ACTIVE_RS19675"
                     /protein_end="37"
                     /protein_start="6"
                     /score="26.6"
                     /tool="antismash"
                     /translation="TVLITGATSGIGAHTARLLLDRGHRVAVTGR"
     gene            1456..2391
                     /locus_tag="ACTIVE_RS19680"
                     /old_locus_tag="ACTIVE_3936"
     CDS             1456..2391
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655643.1"
                     /locus_tag="ACTIVE_RS19680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3936"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_173096441.1"
                     /transl_table=11
                     /translation="MEPPPESHGGDRPDNRSDIRDFLTSRRARLVPEQVGLPTSRRRRV
                     PGLRREEVAALAGVSTEWYTRLEKGHIGGVSEDVLEAVARALLLDEDERTYLLDLARAA
                     RPARRAARPRRRNDVEIPASVQWTVDAMTMAPAFVRNGRLDIVASNALCRALYSPMFDS
                     GTTADRGCANFPRYFFLDPGSSRFFVDWEEGAKATVAVLRAEAGREPHDRSLRELVGEL
                     STLSPEFRTMWASHDVRIHHGGVKRLDHPVVGRLELAFRSLNLPLAQGAVHDLTVYAAE
                     PGTPSEDRLKVLASWTAPPASATEPLLPPR"
     gene            2479..2841
                     /locus_tag="ACTIVE_RS19685"
                     /old_locus_tag="ACTIVE_3937"
     CDS             2479..2841
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS19685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_3937"
                     /product="hypothetical protein"
                     /protein_id="WP_173096442.1"
                     /transl_table=11
                     /translation="MSIFNRVRSNASRYKRGRAAAAISGAYAGLVLVNAAGSVAMGLFA
                     DDPTFSGLGLLLVSAPSSFLVTSLTSPLIPDEGPSRALGVLLFDLPCTTVGLLQAWLLW
                     RIARGPASTDDLRQRC"
     gene            complement(2887..5040)
                     /locus_tag="ACTIVE_RS19690"
                     /old_locus_tag="ACTIVE_3938"
     CDS             complement(2887..5040)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852942.1"
                     /locus_tag="ACTIVE_RS19690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3938"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_173096443.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.2e-23, bitscore:
                     83.0, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 8.9e-20, bitscore:
                     69.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.1e-17, bitscore:
                     62.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIAIGEEHRELARTARAFLRDHDARAANRALLEAAEETLPAFWK
                     EFAGLGLLGLHLPEEHGGGGYGLPELVVVAEELGRAAAPGPLVPTMAASAVIAARGSDE
                     QRARLLPGLASGEVPAALGLDGSVTVQDGGTASGEAVVLGGGLAGLLVLTAGDDVVIVR
                     ADAAGVTVEVPANLDPSRRSARVRLDGAPAEVIEGAAGHAAAIARTLYSAEAVGGALEC
                     VESATEYAKVRQQFGRTIGTFQAVKHHCANMLVAAELGTAAVWDAARAASGPADQFELA
                     AAVAAALAVPAFLDDSGLNIQVHGGIGFTWEHDAHLLMRRAAAIEAAVDPEAAARDVTR
                     LLAAGVVRATTLDLPPEAEAERVEVRELAREIAALPKEEQRVRLIETGYVQPHWPKPWG
                     LEAPAGLQLVIDEEFKAAGVKRPQYGITSWNILTIIQHGSQEQIDRWVRPALLGEEIWC
                     QLFSEPEAGSDAASVKTRAVKTEGGWIVNGQKVWTSGAHYCRWGFATVRTDPDAPKHAG
                     VTMMVIDMEHPGVEVRPLRQITGDSDFNEVFFSDVFVPDADVVGTPNQGWTVARATLGN
                     ERVSIGGGVGSTALLPDLVKLCTEYPDRVPAGAERVGAHEAEAQALRLLNLRSAERAVA
                     GGEPGPEGNITKLVLAEHGHAAAALLSAYAGPELVFAEGLGMIAGRMRLGSRGMSIAGG
                     TSEITRNQIAERILRLPRDPLIK"
     misc_feature    5021..5036
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            complement(5113..5529)
                     /locus_tag="ACTIVE_RS19695"
                     /old_locus_tag="ACTIVE_3939"
     CDS             complement(5113..5529)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620431.1"
                     /locus_tag="ACTIVE_RS19695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3939"
                     /product="VOC family protein"
                     /protein_id="WP_173096444.1"
                     /transl_table=11
                     /translation="MEWKLEVVPVPVSDVDRAKAFYGEQVGFAVDLDREVPGGMRIVQL
                     TPPGSGCSIHLVTGGDAGSLSGLTLVVSDVVAAQAELAGRGVPVGDVVHFENGAQVKGP
                     GTEPWSTMAFFADPDGNAWVVQERPRGAGGQEGV"
     gene            complement(5571..6257)
                     /locus_tag="ACTIVE_RS19700"
                     /old_locus_tag="ACTIVE_3940"
     CDS             complement(5571..6257)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018604.4"
                     /locus_tag="ACTIVE_RS19700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3940"
                     /product="YoaK family protein"
                     /protein_id="WP_173096445.1"
                     /transl_table=11
                     /translation="MAFPAARRAVILPGLAVVAAATDVVSYLGLGHVFTANMTGNTALL
                     GIGIATGKHGAALRSLCALGGFVLGAFAGGLLPSGRRLLAFCLAAEIVPLAAWYAWWET
                     VGGPALGAPRFGYIALAGVAMGLQAAGVTRLGVSGVTTVFITGTMMSFIVGLSTRLHGD
                     RLPNQSRIGHFLQALVVAFFLVGAIATAFTFKYHGAAAVLIPLIVLAVVVPAAYVLPPV
                     DDPEGG"
     gene            complement(6304..7524)
                     /locus_tag="ACTIVE_RS19705"
                     /old_locus_tag="ACTIVE_3941"
     CDS             complement(6304..7524)
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634750.1"
                     /locus_tag="ACTIVE_RS19705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3941"
                     /product="AI-2E family transporter"
                     /protein_id="WP_173096446.1"
                     /transl_table=11
                     /translation="MNDDRHRRSAASASPPAPPLLRAAAAWSWRLIAIGAVGYGVVWII
                     GTLKIVFLPCAIALFLCALLRPLTGRLERAGLPSLAATWITMLIALAVLGGIGTFVGIQ
                     ANEEFPKLATEVQSTARSLQHWLETGPLHVKHSQIQNSIDQGINYLEKRRGKLANTAVQ
                     AGAVTLEVLAAIVLLLFITFFLLKDGGRIWDWTIGGTGRYRARIDRAGRAAWETLSQYV
                     HGTVMVAAIHAVVLAIVLAVLGVPLVAPLAVVIFLGSFIPIVGILVGGALAVAVAFAAK
                     GGVIALIFLGVLIIEHQAESHLLQPLLVGRLVRLHPLAIILAISIGGIVGGIPGAAVAV
                     PIAAVVYRAWPALRDPPEDLPPDVAAATEPSDDEEEPSGGERRDSGDGGARDTDDDGGA
                     GSGKSGG"
     gene            complement(7637..8467)
                     /locus_tag="ACTIVE_RS19710"
                     /old_locus_tag="ACTIVE_3942"
     CDS             complement(7637..8467)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="ACTIVE_RS19710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3942"
                     /product="ABC transporter permease"
                     /protein_id="WP_173096447.1"
                     /transl_table=11
                     /translation="MTVDAPAEPEAGIRTAPPQDAGIGTQLRVLTGRSLRALVLDPRLV
                     VASMLGPLLMLGMFSQLFGSVARAPGFPPGVRYVDFLVPAIMVTSAMQAALNTAVGLTQ
                     EMRNGIIARFRSMPIWPGSVLLARSAADTVRCALQQLLLIVLAAVLLGFRPAGGPLGAL
                     GAAALALAVGCCLGWIFIAIACWIRNTELVQSVAGLATFPLVFASNAFVPASALPGWLR
                     AVVGVNPATYGIRAARAIALGGPALADAATALAVSAAVGAAAAALAIKGFRRGT"
     gene            complement(8464..9456)
                     /locus_tag="ACTIVE_RS19715"
                     /old_locus_tag="ACTIVE_3943"
     CDS             complement(8464..9456)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017598346.1"
                     /locus_tag="ACTIVE_RS19715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3943"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_173096448.1"
                     /transl_table=11
                     /translation="MTGVPAPAGRRRYAVEAAGVSKWFGPVQALDGVTVAAPPGSVLGL
                     LGHNGAGKTTLVNVLATLCRPSAGTARVAGYDVVRQSREVRRRIALTGQFAAVDEQISG
                     RDNLVLVARLRGIGRRAAVRRAAELLETFDLTGAADRPVRGYSGGMRRRLDLAASLTGR
                     PEVLFLDEPTTGLDPAARLATWAAVEDLVRDGTTVVLTTQYLDEADRLADAITVLAAGR
                     VVAAGAPADLKARVGGRTATARLSGPDAVRAAARALRTEGLGPEYDPRRDVLAVPLTGP
                     RDLAVVARTLDAEVAGDYELAVTAPTLDDVYLSLTGPARPDAPAAKDGS"
     gene            complement(9453..10004)
                     /locus_tag="ACTIVE_RS19720"
                     /old_locus_tag="ACTIVE_3944"
     CDS             complement(9453..10004)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="ACTIVE_RS19720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3944"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_173096449.1"
                     /transl_table=11
                     /translation="MTGLVLLGCRALILTVFAAAFVGKARSASRFRGFAGSIRQLAILP
                     ERAAAPAGALVVAGEGTAVVLLALPPAARAGFALASALLALFIGIVVRAVRGGVFAECR
                     CFGSKGSVMGQAMIVRNLLLLAAALPGAIAGAPVPAGRPVAAMVAVVAGALGAWVFTHW
                     YDRIVAALMKRLLAPAGNAG"
     gene            complement(10001..10435)
                     /locus_tag="ACTIVE_RS19725"
                     /old_locus_tag="ACTIVE_3945"
     CDS             complement(10001..10435)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291590.1"
                     /locus_tag="ACTIVE_RS19725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3945"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_173096450.1"
                     /sec_met_domain="PF13471 (E-value: 1.9e-26, bitscore: 91.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPVALEPSVRLTLRRRAGARAAVGAARLIAKLPPRRLRRVLSV
                     LRRGARPASGEEALAARQAVVTVSVQCAGQGCLQRSIATVLLCRAGGTWPDWCTGVRTE
                     PFRAHAWVEADGEPVGERAEVLAFAKTMVIAAAGSAQADR"
     gene            complement(10432..10701)
                     /locus_tag="ACTIVE_RS19730"
                     /old_locus_tag="ACTIVE_3946"
     CDS             complement(10432..10701)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="ACTIVE_RS19730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3946"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_173096451.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.7e-24,
                     bitscore: 83.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 8.8e-15, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVTPGASLSPHVTMTETEHGTVLLDERTGRYWALNATGTTVIRL
                     LLDGGTVDDAVRELRERHPDAAERVTADVAAFVATLRDAEVMAP"
     aSDomain        complement(10444..10677)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_ACTIVE_RS19730_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="1.40E-26"
                     /identifier="RREFam002.1"
                     /label="ACTIVE_RS19730"
                     /locus_tag="ACTIVE_RS19730"
                     /protein_end="86"
                     /protein_start="8"
                     /score="83.3"
                     /tool="antismash"
                     /translation="LSPHVTMTETEHGTVLLDERTGRYWALNATGTTVIRLLLDGGTVD
                     DAVRELRERHPDAAERVTADVAAFVATLRDAEV"
     gene            complement(10692..12518)
                     /locus_tag="ACTIVE_RS19735"
                     /old_locus_tag="ACTIVE_3947"
     CDS             complement(10692..12518)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="ACTIVE_RS19735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3947"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_173096452.1"
                     /sec_met_domain="Asn_synthase (E-value: 3.6e-38, bitscore:
                     131.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEFRVLPDTAAAAALDLPAAARFEHASGRPWIVGRWDRESVVSA
                     ACGRDRLVLFGPADTTPGELERVLARVRSVRDLDALCGRLAGSFHLVASIGGHVRVQGS
                     LAAARQVFHTSLGGVTVAADSPASLPGDHRVDEELLAARLVAPWPPWPISETPLWTGVE
                     TVPAGCYLEIGAAGRGRPVRWWTPPEPHLPLADGARRVRRALHDAVAVRARDVKTVSAD
                     LSGGMDSTSLCFLAADEADRLVTTRWEAADRADEDRHWARLAAEDLPAAEHLVLSRATA
                     PTWFDGIADPGPEPDLEGPFAWIRTRARLTHLARRVAAAGSASHLTGHGGDELFLGNPL
                     NLHTLARTRGGGAVRHLRAYRAMYRWRLLPAARALLNRDSFGAWLAASAGTLTDPVRDV
                     GGAPAFGWGIAYRLPPWATGDAAAAARSLFRRVGASGVEPLAPLRGHHALLQDARLCGD
                     TIRRVDRLTSREGVAWHAPFVDDRVIEAALAVRLRDTTMPDRYKPALSAAMAGIVPARI
                     LGRATKSEYSAEAYDSLRRHRAELLELCGDGMRLARLGLVDAAALRAVLEAPPPSSLTL
                     MPLISTFACETWLRAVERGRVPNPSTGGPRCP"
     gene            complement(12607..12732)
                     /locus_tag="ACTIVE_RS19740"
                     /old_locus_tag="ACTIVE_3948"
     CDS             complement(12607..12732)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014911574.1"
                     /locus_tag="ACTIVE_RS19740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3948"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_173096453.1"
                     /transl_table=11
                     /translation="MQHKVAAYEPPALMAVGGFAELTLGRPSWGFENDWSCVMLC"
     gene            12918..13916
                     /locus_tag="ACTIVE_RS19745"
                     /old_locus_tag="ACTIVE_3949"
     CDS             12918..13916
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630302.1"
                     /locus_tag="ACTIVE_RS19745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3949"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_173096454.1"
                     /transl_table=11
                     /translation="MTILSILDTAPVWQGSSPARALRESLRTAPEAEAMGYHRYWVAEH
                     HNAPFIASCAPPVLVAQLAAATSRIRVGSGGVMLPNHPPLVVAEQFGTLEALNPGRIDL
                     GVGRSPGTDMTTAKALRRVSSPPGSEAYREQVRELVGLLSPRPGDPVAAVPAADGAPDV
                     WLLGSSVENGRFAGELGLPFAFAHHIRPQNAEPALRAYRDAFRPSAAFPEPRTLLASSV
                     IVADSAEHAEWLAGPSKVIVEQSLKGIRNAPNVTPEDAAKRHWTAEEDAILRDRMAHHV
                     IGDPETVRERLGGLLENTGADELMVLTLVHDFDERLRSYELLAKTMSGDGS"
     misc_feature    12919..12933
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            complement(13920..14693)
                     /locus_tag="ACTIVE_RS19750"
                     /old_locus_tag="ACTIVE_3950"
     CDS             complement(13920..14693)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="ACTIVE_RS19750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3950"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_173096455.1"
                     /transl_table=11
                     /translation="MNGVGLKVLGPLEAAVDGRRAELPKGGQRVLLAALALNAGQVVPL
                     DQLLEHLWGDRLPDRPRGALYSCVSRLRQWLDRHSPGSAALLTTSSGGYVLDLGPGRLD
                     LLSFRALMREAAAAGERGDLAAQSARLREALALWRGPVLANVRSDALQQTEVPRLTEEY
                     LRAVEWRCEVGLALGEHDGMVGELRALTDRYPFRERFWWQLMLALSRSGRRVEALAAYR
                     KVSTQLRAEFGVDPDLELRRLQMAILRDDHSVLSL"
     misc_feature    14734..14748
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.45"
                     /tool="antismash"
     misc_feature    14960..14973
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.19"
                     /tool="antismash"
     gene            14986..15615
                     /locus_tag="ACTIVE_RS19755"
                     /old_locus_tag="ACTIVE_3951"
     CDS             14986..15615
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="ACTIVE_RS19755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3951"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_173096456.1"
                     /transl_table=11
                     /translation="MAPTRRVTVAVVDDHDVVLSGVRAWIDGDPRPVEIVDTATSIDGL
                     DPRLAADVLVIDPRTGGEPAFARIAELAAAGHRIVVFSQCAEADLARRAELAGASAFVR
                     KESGECRRRLVEAILAAAAGEPGEAAEPRGTAPCRPQFSEQELRTMRLWLGGLTRAAVA
                     RKMGISEHTVKQYLARAREKYARAGRDASNRIALYREARRDGLLDD"
     gene            15740..15865
                     /locus_tag="ACTIVE_RS48210"
                     /old_locus_tag="ACTIVE_3952"
     CDS             15740..15865
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS48210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_3952"
                     /product="hypothetical protein"
                     /protein_id="WP_281382864.1"
                     /transl_table=11
                     /translation="MERLSAAGAAFRDTVVTGVGGRQILLDDPSGNPVELFQPTS"
     misc_feature    15914..15923
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.67"
                     /tool="antismash"
     gene            15990..17417
                     /locus_tag="ACTIVE_RS19765"
                     /old_locus_tag="ACTIVE_3953"
     CDS             15990..17417
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653474.1"
                     /locus_tag="ACTIVE_RS19765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3953"
                     /product="LCP family protein"
                     /protein_id="WP_173096457.1"
                     /transl_table=11
                     /translation="MSSKPTYIDYADEVDPEPDPAPPRRRGRRVLKWVGIVTAVLVVAA
                     GGTGYGFYWQLQHNIDHEDTDKLIGGNRPPKLNNALNILMLGTDSRAGANAKYGHGMKN
                     DPPRSDTMILLHLSPGGKQAMGISFPRDLMVPIPACRRPDGTASPAVAVGMINSSFTNG
                     GASCTVKTIEDLTHVKIDHFMQVDFTSFKSVTEAVGGVEVCLPEDVNDKDSKLHLKKGR
                     HTIEGETALAFVRDRHGLGDESDLQRIKRQQQFMGSLANKVLSAGTLTDPKKVYDLAEA
                     GTKSLTTDKGLDLGTMVKIARSMHGLTAGKLDFVTAPVTAYAPDPNRVALLQPDAGRFF
                     TAVRQDQSVETAAKKTAGPVQVRLYNATGRASTAAKVAKQLKAQGFVIVGTGTMKTRQA
                     TGVYYAQGSQAQAAALAAVIPGVKKALYPKAGPGVVNLVLGTSFTGVKAKEKAGIPKLE
                     GEIHADGDICAPGATGT"
     gene            complement(17418..18839)
                     /locus_tag="ACTIVE_RS19770"
                     /old_locus_tag="ACTIVE_3954"
     CDS             complement(17418..18839)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631656.1"
                     /locus_tag="ACTIVE_RS19770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3954"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_173096458.1"
                     /transl_table=11
                     /translation="MRVPHVRTLRARLTAGLVVLLALSCLAVGVATTTALHRFLVGRID
                     EQLTVSGGHFAASLEHEYHPDKDNRADSRGQASGTFGARLFQGQVSRAAVVRGQSAVSV
                     PLTGGDARALAGLPPDGRRHDLDLAALGDYRVVAVLGDDGDVLVTGLPLRPVEDTVHRL
                     ELVELTVFAAVLIAAGIAAAAWVRLALRPLRRVAATASRVTELPLASGEVAMPERVPDS
                     DPRTEVGQVGAALNRMLGHVENALARRHASEERLRRFAADASHELRTPVAAIRGHAELA
                     LRTRDGVPADVRHALGRIEAESVRMTELVDDLLLLARLDAGRPLESEPVDLTRLVLDAT
                     GDARAAGPDHRWELVLPEEPVTITGDARRLHQLLANLLANARAHTPPGTHVTVRLAQPH
                     PPGAVLEVEDDGPGVPEDVRDEVFHRFVRADHGRSRAAGGTGLGLAIVQAVAAAHGGTA
                     ELAGRSTFRITLPGG"
     gene            complement(18836..19576)
                     /locus_tag="ACTIVE_RS19775"
                     /old_locus_tag="ACTIVE_3955"
     CDS             complement(18836..19576)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084604.1"
                     /locus_tag="ACTIVE_RS19775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3955"
                     /product="response regulator transcription factor"
                     /protein_id="WP_281382865.1"
                     /transl_table=11
                     /translation="MSTPEPAGAGLRRADGTPVRVLVVDDEPDLAEVLSRVLASEGWSV
                     RSAGDGAGALAAAREFEPDAVVLDVMLPDIGGLEVLRRLRADAPDVCVLFLTARDAVED
                     RIAGITAGGDDYVTKPFSLEEVLARLRGLLRRAGMTRQAGTAGLTVGGLAMDEEAREVT
                     RDGEIVELTPTEFELLRFLMRNPRRVLSKAQILDRVWDYDFGGQAHVVELYISYLRKKI
                     DAGRPPMIHTVRGVGYVLKAPEAP"
     gene            19691..21061
                     /locus_tag="ACTIVE_RS19780"
                     /old_locus_tag="ACTIVE_3956"
     CDS             19691..21061
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851953.1"
                     /locus_tag="ACTIVE_RS19780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3956"
                     /product="ferredoxin reductase family protein"
                     /protein_id="WP_173096459.1"
                     /transl_table=11
                     /translation="MTTTRHDIRRRPVPPAPPAPRAAWRVPSSWPQVLVYAGAVAVLLL
                     WWHGTRSIVGLDGWLTEAGRVTGLLAGYGCAVLLALMARVPALERGVGTDRLARWHAMG
                     GRYTISLICAHVLLIIWGYAVTSHTDVVHQTTSIVFDYPEMLKGTLGFLLLIGVGVTSA
                     RVARRRLRYEIWHYLHFATYLAIFLAFGHQLANGAQFVSSPLARAAWYTLYIGVALVLA
                     WFRFVMPLVRGLRHDLRVAAVRTEAPGVVSVYMTGRHLEELRVQPGQFFRWRFLTRGLW
                     WAANPYSLSETARGGRLRITVKEAGDHSRALAGLRPGTRVWAEGPYGGFTGARPHHDRA
                     LLLAGGVGITPLRTLFETLPGDVVLVYLARRPEDLALRGELDAIAAARGSRVLYFVDEP
                     AGYSLPLTGRALRGLVPDVRHRDVYLCGPPGMTGAALTALKQAGVRRRHIRNESFEF"
     gene            21074..21556
                     /locus_tag="ACTIVE_RS19785"
                     /old_locus_tag="ACTIVE_3957"
     CDS             21074..21556
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631659.1"
                     /locus_tag="ACTIVE_RS19785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3957"
                     /product="FMN-binding protein"
                     /protein_id="WP_173096460.1"
                     /transl_table=11
                     /translation="MRRALIATGTTAAGVVLLLGLKPHHSDVTGVSSSAPQSSAPGTVG
                     GSSAGSSGASSGTSGSSGGSSAKTSGTFKGDVIDTKYGPVQVEITATGGKLTAVRVLQT
                     PSENGRDREIADFSVPQLTKEALAAGNAHIDSVSGATYTSEGYIRSLQSALDAARA"
     gene            21549..22316
                     /locus_tag="ACTIVE_RS19790"
                     /old_locus_tag="ACTIVE_3958"
     CDS             21549..22316
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631660.1"
                     /locus_tag="ACTIVE_RS19790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3958"
                     /product="FAD:protein FMN transferase"
                     /protein_id="WP_216858495.1"
                     /transl_table=11
                     /translation="MPEPSVHHVEHVMGTVFSFDVRSPRTPEITVALARAVAWLHRVDR
                     VFSPYREDSQISRLARGEIDIADCDPDVADILRRCAELERETGGAFSATADGRLDPSGL
                     VKGWAIERASAILHEAGARDHCVNGGGDIQLRGEAAPGEPWRIGLADPADPAALAAVVS
                     GTDLAIATSGTAERGGHIVDPRTGRPAAALASLTLVGRHIAEVDALATAAFVMGGAARE
                     WAAERPGVEAFAIAPDRSRWWTPGFERLALLPG"
     misc_feature    complement(22471..22485)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.09"
                     /tool="antismash"
ORIGIN
        1 acgtccgcct cgacccggcc gtcctggacg cgatcgacga ggtcgtcccg cccggcaccg
       61 acatggcggg catcaagcac ctggtcggca acccgtcgct ggacgccggg aaccgccgcc
      121 gcgcccggtg agcttctacc acgtctgctt cacggtgccc gacctcgcgg cggcgatgcg
      181 cgacctcacc gccgccgcgg gcctggcctg gcgcgacccc gccggcgggc ggctcggcga
      241 atgggactac cggatcgtct tctccgccgg tggagccccg ttcgtcgagc tcatcgaggc
      301 cgcgccgggc gggccgtggg gcgacacgtc ccggccgggc ttccaccacc tcgggttctg
      361 gacgtccgac ctcgcggcgg gaacggcgag gctcaccgat gagggcttcg ccgggacgtt
      421 ctccggctgc ccctacggcc gcgcgttcgc ctaccaccgc gtcgactcga tcggcgcgaa
      481 cgtcgaactc gtcgaccagg gcctccaggc gtccttcctg gacgcctgga accccggcgg
      541 cccgccgatg cccgccatcg acgagcccgg ctgagccgcc gccccgggac cgggcattcc
      601 gaggtcaggc gggctgaccg aggggccgga tggtcagggt gttgaggtcg acgcccgccg
      661 gctggtcgag ggcgtggcag acggcctcgg cgacgggccg gggaggcagg gcgaagggag
      721 gagcgccggc gccctgccag aacggggtgt cgatcatgcc ggggttgacg agggtgacac
      781 ctatgccgcg cgccgtggcg agcaggcgca ggttctcggc gagcccggtg gtggcccact
      841 tggtggccga gtagagattg ccgggagagt tcttcagccc ggcgacgctg ccgatgagca
      901 ccagccgtcc gccggtggcc tacaggtggg gcagggcggc gtgggccaga agggcggggc
      961 cgagaacgtt ggtgaggacc atcggcgccc acgacgccgg gtcgccggcc ccgatggagt
     1021 caccggtcat gaatccggcg ttcgccaccg ccccgtcaag gccaccgaaa cactccacgg
     1081 tgcgggccac ggccgactcg gtggcctccc agtccgccgc gtccgcgacc atccccagca
     1141 gccggtcggg gcggcccacc tcgtccagga aggtcttcag cctgctctcg tcgcgcccgg
     1201 tgacggccac gcggtggccg cggtcgagca gcagccgcgc ggtgtgggcg ccgataccgc
     1261 tggtcgcgcc ggtgatgagt acggtcttgc cggccatggt catgctcctg agatgtagag
     1321 ggggcggcgg acggcgggat gccgaccgaa ccgcgcagcc cacgaaaccg gcgcagtcag
     1381 gggccggcaa ggccgcgttt atggggggta taaacgcaac ctccctatcg gccggtccct
     1441 gagtacggtg gacgaatgga gcctccgccc gagagccacg gcggcgatcg acccgacaac
     1501 cgctcggaca tccgcgactt cctcacgagc cggcgcgcca ggctcgtccc ggaacaggtc
     1561 gggctgccca cgagccggcg gcgccgggtc ccgggactgc gccgcgagga ggtcgcggcc
     1621 ctcgccggcg tgagcaccga gtggtacacg cggctggaga agggccacat cggcggcgtc
     1681 tccgaggacg tgctggaggc ggtcgcccgg gccttgctcc tcgacgagga cgagcgcacc
     1741 tacctgctcg atctggccag agcggctcgc cccgcacgcc gggcggcgcg gccgcggcgc
     1801 cgcaacgacg tcgagatccc ggcctccgtc cagtggacgg tcgacgccat gaccatggcc
     1861 cccgccttcg tgcgcaacgg ccgcctggac atcgtcgcga gcaacgcgct gtgcagggcc
     1921 ctctattcac cgatgttcga cagcgggacc accgccgacc ggggctgcgc caacttcccc
     1981 cgctacttct tcctcgaccc cggctcgtcc cgcttcttcg tcgactggga ggaaggcgcg
     2041 aaggccacgg tcgccgtgct ccgcgccgaa gccggccgcg aacctcacga ccggtccctg
     2101 cgcgagctcg tcggcgagct gtcgacgctc agccccgagt tccgcaccat gtgggccagt
     2161 cacgacgtcc gcatccacca cggcggcgtc aaacggctgg accatcccgt ggtcggccgc
     2221 ctggagctgg cgttccgctc cctgaacctg cccctggctc agggggccgt gcacgacctg
     2281 accgtctacg cggccgagcc gggcaccccc tcggaggacc gcctcaaagt cctcgccagc
     2341 tggacggcac caccggcctc cgccacggaa ccgctcctcc cgccccgctg acctgcccca
     2401 gagccccggc aggcacccca cgccaacccg agtacttgta ctcatggcag cggcactgcg
     2461 gctgaccagt atggacgcat gtcgatcttc aaccgcgtgc gctcgaacgc atcccgatac
     2521 aagcgcggcc gggcggccgc cgcgatctcc ggcgcctatg cgggcctggt cctggtcaac
     2581 gccgcgggca gcgtggccat gggcctcttc gccgacgacc cgacgttcag cggcctcggg
     2641 ctcctgctcg tgagtgcgcc gtcgtcattc ctcgtcacga gcctcacctc ccccctgatc
     2701 ccggatgagg ggccgtcacg ggcgctgggg gtgctgttgt tcgaccttcc ctgcacgacg
     2761 gtcggtctgc tccaggcatg gctgctctgg cgcatcgccc ggggccccgc gagcacggac
     2821 gatctgcgtc agcgctgctg aacccggagc cgggggttcc ggtgcggccg gaacccccgg
     2881 gcgcggtcac ttgatcagcg ggtcgcgggg gaggcggagg atccgctcgg cgatctggtt
     2941 gcgggtgatc tcggacgtgc cgcccgcgat cgacatgccg cgcgaaccga gccgcatccg
     3001 gcccgcgatc atgccgaggc cctcggcgaa caccagctcg ggacccgcgt aggccgacag
     3061 cagggccgcc gcggcgtgcc cgtgctcggc gagcacgagc ttggtgatgt tgccctccgg
     3121 gccgggctcg ccgcccgcga cggcccgctc ggcgctgcgc aggttcagca gccgcagtgc
     3181 ctgcgcctcc gcctcgtgcg cgccgacgcg ctcggcgccg gccggcaccc ggtccgggta
     3241 ctcggtgcac agcttcacca ggtcgggcag cagcgcggtg gagccgacgc cgccgccgat
     3301 gctgacccgc tcattgccga gcgtggcgcg ggcgaccgtc cagccctggt tcggggtgcc
     3361 gacgacgtcg gcgtcgggga cgaagacgtc ggagaagaac acctcgttga agtcggagtc
     3421 accggtgatc tggcggagcg ggcggacctc cacgcccggg tgctccatgt cgatcaccat
     3481 catggtgacg ccggcgtgct tgggcgcgtc ggggtcggtg cggacggtcg cgaagcccca
     3541 gcggcagtag tgcgcgccgc tcgtccacac cttctggccg ttgacgatcc agccgccctc
     3601 ggtcttcacg gcgcgggtct tcaccgacgc ggcgtccgag ccggcctccg gctcgctgaa
     3661 cagctggcac cagatctcct cgccgagcag cgcgggccgc acccagcggt cgatctgctc
     3721 ctgggagccg tgctggatga tggtgaggat gttccagctg gtgatgccgt actgcgggcg
     3781 cttcacgccg gcggccttga actcctcgtc gatgacgagc tggagccccg ccggggcctc
     3841 gaggccccac ggcttcggcc agtgcggctg gacgtagccg gtctcgatga ggcggacgcg
     3901 ctgctcctcc ttgggcaggg cggcgatctc gcgggccagc tcgcggacct cgacgcgctc
     3961 ggcctcggcc tccggcggca ggtcgagggt ggtggcgcgg acgaccccgg cggcgagcag
     4021 ccgggtgacg tcgcgggcgg cggcctccgg gtcgacggcc gcctcgatcg cggcggcgcg
     4081 gcgcatcagc aggtgcgcgt cgtgctccca ggtgaagccg atgccgccgt gcacctggat
     4141 gttcagcccg gagtcgtcga ggaacgccgg gaccgcgagg gcggcggcga ccgccgcggc
     4201 cagctcgaac tggtcggccg ggccggacgc ggcgcgcgcc gcgtcccaca cggcggcggt
     4261 gccgagctcg gcggcgacca gcatgttcgc gcagtggtgc ttgacggctt ggaacgtgcc
     4321 gatcgtgcgg ccgaactgct gccggacctt cgcgtactcg gtggccgact cgacgcattc
     4381 cagggcgccg ccgaccgcct cggcggagta gagcgtgcgg gcgatcgcgg ccgcgtgccc
     4441 ggcggcgccc tcgatcacct cggcgggcgc cccgtcgagg cggacccggg cgctgcgccg
     4501 ggacgggtcg aggttcgccg ggacctcgac ggtcacgccc gccgcgtccg cccggacgat
     4561 caccacgtcg tcgccggcgg tgaggaccag cagcccggcg agcccgccgc cgagcaccac
     4621 ggcctcgccg gacgcggtgc cgccgtcctg cacggtcacg gagccgtcca gtccgagggc
     4681 ggccgggacc tcgccggacg ccaggcccgg cagcagccgc gcgcgctgct cgtcgctccc
     4741 gcgcgcggcg atcaccgcgg acgccgccat cgtcgggacg agcgggccgg gcgcggcggc
     4801 ccggcccagc tcctccgcga cgacgacgag ctcggggagg ccgtacccgc cgccgccgtg
     4861 ctcctcgggc aggtgcaggc cgagcaggcc gagaccggcg aactccttcc agaacgctgg
     4921 gagcgtctcc tcggcggcct ccagcagcgc ccggttcgcg gcgcgcgcgt cgtggtcgcg
     4981 caggaacgcg cgcgccgtcc gcgccagttc gcgatgctcc tcgccgatgg cgatcgccat
     5041 ggatcctccc agggtgttcc gcgcctgcgg cgcaggtcgg gtcggtgtgc cgctcagcta
     5101 ataatcgctc gcttacaccc cctcctgtcc accggccccc cgcggacgct cctgcaccac
     5161 ccaggcgttc ccgtccgggt cggcgaagaa cgccatcgtg ctccagggct ccgtgcccgg
     5221 ccccttgacc tgcgcgccgt tctcgaagtg cacgacgtca ccgaccggga cgccgcgtcc
     5281 ggccagctcg gcctgcgccg cgaccacgtc ggacacgacc agcgtcagcc cgctgaggct
     5341 ccccgcgtca ccgccggtga ccaggtggat cgagcagccg gagccgggcg gcgtcagctg
     5401 gacgatccgc atcccgcccg gcacctcccg gtcgaggtcg accgcgaacc cgacctgctc
     5461 cccatagaac gccttggccc ggtccacgtc ggagacgggc accggcacga cttccaattt
     5521 ccattccatg gcgggaacga ccttcggcgg cgccggaact catcgcttcc tcagccgcct
     5581 tcgggatcgt ccaccggcgg gaggacgtaa gccgccggaa cgacgaccgc gagcacgatc
     5641 agcggaatga gcaccgccgc cgccccgtgg tacttgaacg tgaatgcggt ggcgatcgcc
     5701 ccgaccagga agaaggcgac gacgagcgcc tgcaggaaat ggccgatgcg gctctggttc
     5761 ggcagccggt ccccgtgcag gcgggtgctc aggccgacga tgaaggacat catggtgccg
     5821 gtgatgaaga cggtcgtcac gccggacacg cccagccgcg tgacccctgc ggcctgcagc
     5881 cccatcgcga cgcccgccag tgcgatgtag ccgaacctcg gggcgcccag cgccggcccg
     5941 ccgaccgttt cccaccacgc gtaccaggcc gccaagggca cgatttcggc cgccaggcag
     6001 aacgcgagaa gccgccgtcc ggacgggaga aggccgcccg cgaaggcgcc caggacgaaa
     6061 ccgccgagcg cgcagagaga gcgcagggcc gcgccgtgct tcccggtcgc gatgccgatt
     6121 ccgagcagcg cggtgttccc ggtcatgttc gccgtgaaaa cgtgcccgag gccgagatag
     6181 ctgaccacgt ccgtcgcggc ggcgacaacg gcgaggcccg gcaggatgac ggcccgcctg
     6241 gccgctggga aggccatgca ccggcactac ccggcggccg ccgcgccatt cggaacggcc
     6301 gggtcagccg ccggacttcc cgctgcccgc gcccccgtca tcatccgtat cccgcgcgcc
     6361 gccgtccccg gagtcgcgcc gctcgccgcc tgacggctcc tcttcatcgt cggacggctc
     6421 ggtggcggcg gcgacgtccg gcggcaggtc ctcgggcggg tcgcgcagcg cgggccacgc
     6481 ccggtacacg accgcggcga tcggcaccgc gacggccgcg ccagggatcc cgccgacgat
     6541 cccgccgatg ctgatcgcga ggatgatggc gagcgggtgc agccggacga gccgtccgac
     6601 cagcagcggc tgcagcagat ggctctcggc ctggtgctcg atgatcagca cgccgaggaa
     6661 gatcagcgcg atgacgccgc ccttggcggc gaacgcgacg gcgaccgcga gcgcgccgcc
     6721 gaccaggatc ccgacgatcg ggatgaagct gcccaggaag atcaccacgg cgagcggcgc
     6781 gaccagcggg acgccgagga cggccagcac gatcgcgagc acgacggcgt ggatcgcggc
     6841 gaccatgacg gtgccgtgca cgtactgcga cagcgtctcc caggcggcgc ggccggcccg
     6901 gtcgatgcgg gcgcggtagc ggcccgtccc gccgatcgtc cagtcccaga tccgcccgcc
     6961 gtccttgagc aggaagaacg tgatgaacag cagcagcacg atcgcggcga gcacctcgag
     7021 ggtgaccgcg cccgcctgca ccgcggtgtt ggcgagcttg ccgcgccgct tctccaggta
     7081 gttgatgccc tggtcgatgg agttctggat ctgggagtgc ttgacgtgca gcggaccggt
     7141 ctccagccag tgctgcaggg accgggcggt ggactgcacc tcggtggcga gcttggggaa
     7201 ctcctcgttc gcctggatcc cgacgaacgt gccgatcccg ccgagcaccg cgagcgcgat
     7261 cagcatggtg atccaggtgg cggccagcga cggcagcccc gcccgctcca gccggccggt
     7321 gagggggcgc agcagcgcgc acaggaacag cgcgatggcg cacggcagga agacgatctt
     7381 cagggtgccg atgatccaga cgacgccgta gccgaccgcg ccgatcgcga tcagccgcca
     7441 ggaccaggcc gcggccgctc tgagcagggg cggtgccggt ggtgaggccg acgccgcgga
     7501 ccgccggtgc cgatcgtcgt tcatccgcgc cccttcgccg ggacgccggt cttctccccc
     7561 acccaacgca ctctatgcgc cgaagcgccg gcaagtgccg cgccgaagcg ccggcaagtg
     7621 ccgcgccgga ccgccgtcag gtgccgcgcc ggaagccctt gatcgcgagc gcggcggccg
     7681 cggcgccgac ggcggcgctg accgcgaggg cggtggcggc gtcggcgagc gcggggccgc
     7741 cgagcgcgat ggcccgcgcc gcgcggatcc cgtaggtggc cgggttgacg ccgacgacgg
     7801 cgcgcagcca gccgggcagc gcgctcgccg ggacgaacgc gttggaagcg aagaccagcg
     7861 ggaacgtcgc caggcccgcg acggactgca cgagctcggt gttgcggatc cagcaggcga
     7921 tggcgatgaa tatccagccg aggcagcagc cgacggcgag cgcgagcgcc gcggcgccga
     7981 gcgcgccgag cggcccgccc gccggccgga acccgagcag caccgcggcg aggacgatca
     8041 gcagcagctg ctggagcgcg cagcggacgg tgtcggcggc gctgcgggcg agcagcaccg
     8101 acccgggcca gatcggcatc gaccggaacc gggcgatgat cccgttgcgc atctcctggg
     8161 tgagcccgac cgcggtgttc agcgccgcct gcatcgccga cgtcaccatg atcgcgggga
     8221 cgaggaagtc gacgtagcgg acgcccggcg ggaagcccgg cgcccgcgcg acgctgccga
     8281 acagctggct gaacatgccg agcatcagca gcggcccgag catgctcgcg acgacgagcc
     8341 gcgggtcgag cacgagcgcg cgcagcgacc ggccggtgag gacgcgcagc tgcgtgccga
     8401 tcccggcgtc ctgcgggggc gccgtgcgga tgcccgcttc gggctcggcg ggcgcgtcga
     8461 ccgtcatgac ccgtccttcg cggccggcgc gtccgggcgg gcgggcccgg tgagggacag
     8521 gtacacgtcg tcgagggtcg gggcggtcac ggccagctcg tagtcgcccg cgacctcggc
     8581 gtccagcgtc cgcgcgacga cggcgaggtc gcgggggccg gtgagcggga cggcgaggac
     8641 gtcgcggcgc gggtcgtact cgggcccgag cccctcggtg cgcagcgcgc gggcggcggc
     8701 gcggacggcg tccggcccgg acagccgcgc ggtggcggtg cggccaccga cgcgggcctt
     8761 caggtcggcg ggcgcgccgg ccgcgacgac ccggccagcg gcgagcacgg tgatggcgtc
     8821 ggcgagccgg tccgcctcgt cgaggtactg ggtggtgagc acgacggtcg tcccgtcgcg
     8881 gacgaggtcc tcgacggcgg cccaggtggc gaggcgggcg gcggggtcca ggccggtggt
     8941 gggctcgtcg aggaacagca cctcgggacg gcccgtcagg ctggccgcga ggtcgaggcg
     9001 gcgccgcatc ccgccggagt agccgcggac gggccggtcg gcggcgccgg tcaggtcgaa
     9061 cgtctccagc agttcggcgg cgcggcggac cgcggcgcgc cgcccgatcc cgcgcagccg
     9121 ggcgaccagg accaggttgt cgcgcccgga gatctgctcg tcgacggccg cgaactgccc
     9181 ggtcagcgcg atgcggcggc gcacctcgcg ggactgccgg acgacgtcgt acccggcgac
     9241 gcgggctgtg ccggcgctgg gccggcacag cgtggcgagc acgttgacca gcgtggtctt
     9301 gccggcgccg ttgtgcccga gcaggccgag caccgagccg ggcggcgcgg cgaccgtcac
     9361 cccgtccagc gcctggaccg gcccgaacca cttgctgacg cccgcggcct cgaccgcgta
     9421 ccggcggcgg cccgcggggg cgggcacgcc ggtcatccgg cgttccccgc cggggcgagc
     9481 agccgcttca tcagcgccgc gacgatccgg tcgtaccagt gggtgaagac ccacgcgccg
     9541 agcgccccgg cgacgaccgc gaccatcgcc gcgacgggcc gtccggcggg gacgggcgcg
     9601 cccgctatgg cgccgggcag cgcggcggcg agcagcagca ggttccggac gatcatcgcc
     9661 tgccccatca ccgagccctt cgagccgaag cagcggcact cggcgaacac gccgccgcgc
     9721 accgcgcgca ccacgatgcc gatgaacagc gcgagcagcg cggacgcgag cgcgaacccg
     9781 gcgcgggccg cgggcggcag cgccagcagc acgaccgcgg tcccctcgcc cgcgacgacc
     9841 agcgcgcccg ccggcgccgc ggcccgttcc ggcaggatcg cgagctgccg gatcgagccg
     9901 gcgaacccgc ggaaccggga cgcgctgcgc gccttgccga cgaacgcggc ggcgaacacg
     9961 gtcaggatca gcgcccggca gccgagcagg accaggcccg tcatcggtcc gcctgcgcgc
    10021 tgccggcggc cgcgatcacc atcgtcttgg cgaacgccag cacctcggcg cgctcgccga
    10081 ccggctcgcc gtcggcctcc acccacgcgt gcgcccggaa cggctccgtg cgcacgcccg
    10141 tgcaccagtc cggccacgtc ccgccggccc ggcacagcag caccgtcgcg atggaccgct
    10201 gcaggcagcc ctggccggcg cactggacgc tcaccgtcac caccgcctgc cgcgccgcga
    10261 gcgcctcctc gcccgacgcg ggccgcgcgc cccgccgcag gacggacagg acgcggcgca
    10321 gccggcgcgg cggcagcttc gcgatcagcc gggcggcgcc gaccgcggcg cgggcgccgg
    10381 cccgccgccg cagcgtcagc cggaccgacg gctccagcgc gaccgggatc gtcacggggc
    10441 catcacctcg gcgtcgcgga gcgtcgcgac gaacgcggcg acgtcggcgg tgacccgctc
    10501 cgccgcgtcc gggtgccgct cccgcagctc gcggacggcg tcgtcgacgg tcccgccgtc
    10561 cagcagcagc cggatcacgg tggtgccggt cgcgttcagc gcccagtagc ggccggtgcg
    10621 ctcgtccagc agcaccgtgc cgtgctcggt ctcggtcatg gtcacgtggg gcgacagcga
    10681 cgccccggga gtcacgggca tctcggacct ccggtcgagg ggttcgggac gcggccgcgc
    10741 tcgacggcgc gcagccacgt ctcgcaggcg aacgtgctga tcagcggcat caaggtcagg
    10801 gacgagggcg gcggcgcctc cagcacggcg cgcagcgcgg cggcgtcgac gagcccgagc
    10861 cgcgcgaggc gcatgccgtc gccgcacagc tcgagcagct cggcgcggtg ccgccgcagg
    10921 ctgtcgtagg cctccgcgct gtactccgac ttcgtcgccc ggccgaggat ccgggcgggg
    10981 acgatgccgg ccatcgcggc ggacagggcg ggcttgtagc ggtcgggcat cgtggtgtcg
    11041 cgcagccgga cggcgagcgc ggcctcgatg acccggtcgt cgacgaacgg cgcgtgccag
    11101 gccacgccct cccgggaggt gagccggtcg acgcggcgga tcgtgtcgcc gcagagccgg
    11161 gcgtcctgca gcagggcgtg gtgcccgcgc agcggcgcca gcggctccac gccggacgcg
    11221 ccgacccgcc ggaacaggct ccgcgccgcc gcggcggcgt cgccggtcgc ccacggcggc
    11281 agccggtagg cgatgcccca gccgaacgcg ggcgcgccgc cgacgtcgcg gaccgggtcg
    11341 gtgagcgtcc cggcggacgc ggcgagccac gcgccgaacg agtcgcggtt cagcagcgcc
    11401 cgcgccgcgg gcagcagccg ccaccggtac atcgcccggt aggcgcgcag gtggcggacg
    11461 gcgccgccgc cgcgcgtgcg cgccagcgtg tgcaggttga gcgggttgcc gaggaacagc
    11521 tcgtcgccgc cgtggccggt caggtgggac gccgagccgg cggcggcgac gcggcgcgcc
    11581 aggtgggtga gccgggcccg cgtcctgatc cacgcgaacg gcccctccag gtcgggctcg
    11641 gggccggggt cggcgatccc gtcgaaccag gtcggggcgg tggcgcggga cagcaccagg
    11701 tgctcggcgg cgggcaggtc ctcggcggcg agccgcgccc agtgccggtc ctcgtcggcg
    11761 cggtcggcgg cctcccagcg ggtcgtgacg agccggtccg cctcgtccgc ggcgaggaag
    11821 cacaggctgg tggagtccat cccgccggac aggtccgcgc tgaccgtctt gacgtcgcgc
    11881 gcccgcacgg cgaccgcgtc gtgcagcgcc cggcggacgc ggcgcgcccc gtcggccagc
    11941 ggcaggtgcg gctccggcgg cgtccaccac cggaccgggc ggccgcgccc ggcggcgccg
    12001 atctccaggt agcagccggc ggggaccgtc tcgacgcccg tccacagcgg cgtctcgctg
    12061 atcggccacg gcggccaggg tgcgacgagc cgggccgcga gcagttcctc gtccacccgg
    12121 tggtcgccgg gcagggacgc cggcgagtcg gcggcgacgg tgacgccgcc gagcgaggtg
    12181 tggaagacct gcctcgcggc ggccaggctg ccctgcaccc ggacgtgccc gccgatggac
    12241 gcgacgaggt ggaagcttcc ggcgagccgc ccgcacaggg cgtccaggtc gcggacggag
    12301 cggacgcggg cgaggacgcg ctccagctcg ccgggggtcg tgtcggcggg cccgaacagc
    12361 acgaggcggt cgcgcccgca cgcggcggac acgacgctct cccggtccca gcggccgacg
    12421 atccacgggc ggcccgaggc gtgctcgaac cgcgcggcgg ccgggaggtc cagcgcggcg
    12481 gccgcggcgg tgtccggaag gacgcggaac tccaccattt ccctttccct ttttcaccgg
    12541 ccgtgccggc gccgggctga accggcgccg gcacggccgt tccgagccga cgggccgcgc
    12601 ggtgactcag cagagcatga cgcacgacca gtcgttctcg aagccccagc tcggccggcc
    12661 gagggtcagc tcggcgaagc cgcccaccgc catcagcgcg ggcggctcgt aagccgcgac
    12721 cttgtgctgc atgaaacaca ccctccttgc gaaccgaggc ggcccccgga tgggcctccc
    12781 cgttgcgcta ccacattagg agggcggtca tttcagttac cttgcagttg cctttcagcg
    12841 gggcgccgcg ctcttgagct ctccggttac cggcgcgaat atcggcaggg cagcggaacc
    12901 gaccgaagga gccggcgatg acgatcctgt ccatcctcga cacagcgccc gtgtggcagg
    12961 gctcgtcgcc ggcgcgggcg ctgcgcgagt cgctgcggac ggcgccggag gcggaggcga
    13021 tggggtacca ccggtactgg gtcgccgagc accacaacgc gccgttcatc gccagctgcg
    13081 cgccgccggt gctcgtcgcg cagctcgccg ccgcgacgtc ccggatccgg gtcggctcgg
    13141 gcggggtgat gctgccgaac catccgccgc tggtcgtcgc cgagcagttc gggacgctgg
    13201 aggcgctgaa cccgggccgc atcgacctcg gcgtcggccg ctcccccggc accgacatga
    13261 ccacggcgaa ggcgctgcgc cgggtcagca gcccgcccgg ttcggaggcg taccgggagc
    13321 aggtccgcga gctggtcggg ctgctgtcgc cgcgtccggg cgacccggtc gccgcggtcc
    13381 cggcggcgga cggcgcgccg gacgtgtggc tcctcgggtc cagcgtcgag aacggccgtt
    13441 tcgccggcga gctggggctg ccgttcgcgt tcgcgcacca catccggccg cagaacgccg
    13501 agcccgcgct gcgcgcctac cgcgacgcgt tccggccatc cgcggcgttc ccggaaccgc
    13561 ggacgctgct cgcctcgtcg gtcatcgtcg ccgattccgc cgagcacgcc gaatggctcg
    13621 ccgggccgtc caaggtcatc gtcgagcagt ccttgaaagg catccggaac gcgccgaacg
    13681 tcacccccga ggacgccgcg aagcgccatt ggacggccga agaggacgcg attctccgcg
    13741 accgcatggc gcaccatgtg atcggcgacc cggaaaccgt ccgggaacgc ctcggcggac
    13801 ttctcgaaaa caccggggcc gacgaactca tggtgctgac gctcgtgcac gacttcgacg
    13861 aacggctgcg ctcctatgaa ctgctcgcca agacgatgtc gggggacggt tcctgacggt
    13921 cacaatgaca ggaccgaatg gtcgtcgcgc aggatcgcca tctgcaggcg gcggagttcg
    13981 agatcggggt cgacgccgaa ctcggcgcgc agctgcgtgc tgaccttccg gtacgcggcg
    14041 agcgcctcga cgcggcggcc cgaccgggac agcgccagca tcagctgcca ccagaagcgc
    14101 tcccggaacg ggtaccggtc ggtcagcgcg cgcagctccc cgaccatccc gtcgtgctcg
    14161 ccgagcgcca gcccgacctc gcaccgccac tccaccgccc gcaggtactc ctcggtcagc
    14221 cgcggcacct ccgtctgctg cagggcgtcg gaccggacgt tcgccagcac gggcccgcgc
    14281 cacagcgcca gcgcctcccg cagccgcgcg gactgggcgg cgaggtcgcc gcgctccccc
    14341 gcggcggcgg cctcgcgcat cagcgcgcgg aagctcagca ggtccaggcg cccgggcccg
    14401 aggtccagca cgtacccgcc ggaggaggtg gtgagcagcg cggcggagcc cggcgagtgc
    14461 cggtcgagcc actgccgcag ccgcgacacg caggagtaca gcgcgccgcg cggccggtcg
    14521 ggcagccggt cgccccacag gtgctccagc agctggtcga gcgggacgac ctgcccggcg
    14581 ttcagcgcca gcgcggcgag cagcacccgc tggcccccct tcggcagctc cgcccgccgg
    14641 ccgtcgacgg ccgcctccag cggaccgagg accttcagac cgaccccgtt catgtggttc
    14701 ccccctgcgt cggtacggct gcttcggcag tacggctcag tttgcgcaga gtcgggtcgt
    14761 ctgtcatgac ggtcgttcgg cggtcatggc ccccgcgcgg gcggggtggc ggccgtcacc
    14821 ggtgggccat tcagaactct ctatgacggg acggtctcgc tcagtaagat cgaggggttg
    14881 ccgctccccg ctccgcaccg cccgtccgcg cacgcccctg cccgcagaac gctcccgccc
    14941 gcacgcacgc tccccgcccc gaacaaaggt ctgacccgct ccccgatggc tcccacccgc
    15001 cgagtcaccg tcgccgtcgt cgacgaccac gacgtggtgc tgtccggcgt ccgcgcctgg
    15061 atcgacggcg acccgcgccc cgtcgagatc gtggacaccg cgaccagcat cgacggcctc
    15121 gacccgcgcc tcgccgccga cgtgctggtc atcgacccgc ggacgggcgg ggagccggcg
    15181 ttcgcgcgga tcgccgagct ggccgcggcg gggcaccgga tcgtcgtgtt ctcccagtgc
    15241 gccgaggccg acctcgcccg gcgggccgag ctggcggggg ccagcgcgtt cgtccgcaag
    15301 gagtccgggg agtgccggcg ccggctggtt gaggcgatcc tcgccgcggc cgccggcgag
    15361 cccggcgagg ccgcggagcc gcgcgggacg gcgccctgcc gcccgcagtt ctccgagcag
    15421 gagctgcgga cgatgcggct gtggctgggc ggcctcaccc gcgccgccgt cgcccgcaag
    15481 atgggcatca gcgagcacac ggtcaagcag tacctcgccc gcgcccggga gaagtacgcc
    15541 agggccggcc gcgacgcctc caaccggatc gcgctgtacc gcgaggcgcg ccgcgacggc
    15601 ctcctcgacg actaggacgc cttcccgaga ccgggcccgc tttccccaag atcgggcagc
    15661 gccggaatgg ggcacccgag cggaggcagc agaggagcat ggcagaaacc gtgctcgtgg
    15721 tggcgacatc gacgccgagg tggagcggct gagcgcggcg ggcgcggcgt tccgcgacac
    15781 cgtcgtcacc ggcgtgggcg ggcggcagat cctgctcgac gacccgtccg gtaaccctgt
    15841 ggagttgttc cagccgacct cgtgaccatc attcctaggg cgcgcaggct agaggatact
    15901 gtcgtctgag tcacgtgttt tgagcaaggt tcgactgagc gcggtggccg ctgaccggtg
    15961 ctcacgattc agacggggtc gctggagcga tgagcagcaa gccgacgtac atcgactacg
    16021 cggacgaggt ggatcccgag cccgatccgg cgccgccgcg gcggcgcggc cggcgggtgc
    16081 tgaagtgggt cgggatcgtg accgcggtgc tggtcgtcgc ggccggcggc accggctacg
    16141 gcttctactg gcagctgcag cacaacatcg accacgagga caccgacaag ctgatcggcg
    16201 ggaaccggcc gccgaagctg aacaacgcgc tgaacatcct gatgctcggc accgacagcc
    16261 gcgcgggcgc caacgccaag tacgggcacg gcatgaagaa cgacccgccg cgctcggaca
    16321 cgatgatcct gctgcacctg tcgccgggcg ggaagcaggc gatgggcatc agcttcccgc
    16381 gcgacctgat ggtgccgatc ccggcgtgcc gccggcccga cggaaccgcc tcgcccgcgg
    16441 tggcggtcgg gatgatcaac agctcgttca ccaacggcgg cgcgtcctgc acggtcaaga
    16501 cgatcgagga cctcacccac gtcaagatcg accacttcat gcaggtcgac ttcaccagct
    16561 tcaagagcgt caccgaggcg gtcggcggcg tggaggtctg cctgccggag gacgtgaacg
    16621 acaaggactc caagctgcac ctgaaaaagg gcaggcacac catcgagggc gagacggcgc
    16681 tggcgttcgt ccgcgaccgg cacggcctcg gcgacgagtc cgacctgcag cggatcaagc
    16741 ggcagcagca gttcatgggg tcgctggcga acaaggtgct gagcgccggc acgctcaccg
    16801 acccgaagaa ggtctacgac ctggcggagg ccggcacgaa gtcgctgacc accgacaagg
    16861 gcctggacct cggcacgatg gtgaagatcg cgcggagcat gcacgggctg accgccggca
    16921 agctcgactt cgtcaccgcg cccgtcaccg cgtacgcgcc ggacccgaac cgggtggcgc
    16981 tgctccagcc ggacgcgggc cggttcttca cggccgtccg ccaggaccag tccgtcgaga
    17041 cggccgcgaa gaagacggcc gggccggtgc aggtgcggct ctacaacgcg accgggcgcg
    17101 cgagcacggc ggcgaaggtc gccaagcagc tcaaggcgca gggcttcgtg atcgtcggga
    17161 cgggcaccat gaagacccgg caggcgaccg gcgtctacta cgcgcagggc tcgcaggcgc
    17221 aggccgccgc gctcgccgcg gtgatcccgg gcgtgaagaa ggcgctgtac cccaaggccg
    17281 ggccgggggt cgtgaacctc gtcctcggca cctcgttcac cggggtgaag gcgaaggaga
    17341 aggccggcat cccgaagctc gaaggcgaga tccacgccga cggcgacatc tgcgcgccgg
    17401 gcgcgacggg gacgtgatca gccgcccggc agggtgatcc ggaacgtcga ccggcccgcc
    17461 agctccgccg tgccgccgtg cgcggcggcg acggcctgca cgatcgcgag cccgagcccg
    17521 gtgccgcccg cggcgcggga ccggccgtgg tcggcgcgga cgaaccggtg gaacacctcg
    17581 tcgcggacgt cctccgggac gcccggcccg tcgtcctcga cctccagcac ggcgcccggc
    17641 gggtgcggct gggcgagccg gaccgtgacg tgggtgccgg gcggggtgtg ggcgcgggcg
    17701 ttggcgagca ggttcgcgag gagctggtgc agccggcggg cgtcgccggt gatcgtgacc
    17761 ggctcctcgg gcagcaccag ctcccagcgg tggtccggcc cggcggcgcg ggcgtcgccg
    17821 gtggcgtcca gcacgagccg ggtcaggtcc acgggctcgg actccagcgg gcggcccgcg
    17881 tccagccggg cgaggagcag caggtcgtcg accagctcgg tcatccggac ggactcggcc
    17941 tcgatccggc cgagcgcgtg ccggacgtcg gccgggacgc cgtcgcgggt gcgcagcgcc
    18001 agctcggcgt ggccgcggat cgcggcgacg ggggtgcgca gctcgtggct ggcgtcggcg
    18061 gcgaaccggc gcagccgctc ctcgctcgcg tgccgccgcg cgagcgcgtt ctcgacgtgg
    18121 ccgagcatcc ggttgagcgc ggcgccgacc tgcccgacct cggtgcgcgg gtcgctgtcg
    18181 gggacgcgct cgggcatcgc gacctcgccg ctggccagcg gcagctcggt gacgcgggac
    18241 gcggtcgcgg cgacgcggcg cagcggccgc agcgcgagcc gcacccacgc cgccgcggcg
    18301 atcccggcgg cgatcagcac ggcggcgaac acggtgagct ccaccagctc cagccggtgc
    18361 acggtgtcct cgacgggccg cagcggcagc ccggtgacca gcacgtcgcc gtcgtcgccg
    18421 aggacggcca cgacgcggta gtcgccgagc gccgccaggt ccaggtcgtg cctgcggccg
    18481 tcgggcggca ggccagcgag ggcgcgggcg tcgccgccgg tcagcggcac cgacacggcg
    18541 gactgcccgc gcacgaccgc ggcgcgggac acctgcccct ggaacagccg ggcgccgaac
    18601 gtccccgacg cctggccgcg cgagtccgcg cggttgtcct tgtcagggtg gtactcgtgc
    18661 tcgaggctgg ccgcgaagtg cccgccgctc acggtgagct gctcgtcgat ccggcccacg
    18721 aggaaccggt gcagcgcggt cgtcgtggcg accccgaccg cgaggcagct gagcgccagc
    18781 aggacgacca ggcccgcggt cagccgcgcc cgcagcgtcc ggacgtgcgg gaccctcacg
    18841 gggcctccgg cgccttcagc acgtacccga cgccccggac ggtgtggatc atcggcggcc
    18901 ggcccgcgtc gatcttcttg cgcaggtagc tgatgtacag ctcgacgacg tgcgcctgcc
    18961 cgccgaagtc gtagtcccag acccggtcga ggatctgcgc cttggacagc acccggcgcg
    19021 ggttgcgcat caggaaccgc agcagctcga actcggtcgg ggtcagctcg acgatctccc
    19081 cgtcccgggt gacctcgcgg gcctcctcgt ccatcgccag gcccccgacg gtcaggcccg
    19141 ccgtcccggc ctgccgggtc atcccggcgc ggcgcagcag cccgcgcagc cgggcgagga
    19201 cctcctccag gctgaacggc ttggtgacgt agtcgtcacc gcccgcggtg atcccggcga
    19261 tccggtcctc gacggcgtcc cgggcggtga ggaacagcac gcacacgtcc ggggcgtcgg
    19321 cccgcagccg ccgcagcacc tccaggccgc cgatgtcggg cagcatcacg tccaggacga
    19381 cggcgtccgg ctcgaactcg cgggcggcgg cgagggcgcc cgcgccgtcc ccggcgctgc
    19441 gcaccgacca gccctcggac gccagtacgc gcgacaggac ctcggcgagg tcgggttcat
    19501 cgtcgacgac caggacgcgg acgggcgtgc cgtcggcgcg gcgcagtccg gcgccggcgg
    19561 gttcgggagt gctcatgatg gtcccagcct ccctctccga cctctgcgtt tcctcagaga
    19621 aacctctcaa ccggtccttt tccccgcgga tcagaaggaa ctcagaaact cggttggcag
    19681 ggtggcccgc atgaccacga ccaggcatga catcaggcgg cgccccgtgc cgccggcgcc
    19741 gcccgccccg cgggcggcgt ggcgcgtccc gtcctcgtgg ccacaggtgc tggtctacgc
    19801 gggcgcggtg gccgtgctgc tgctctggtg gcacggcacc cggtcgatcg tcggcctgga
    19861 cggctggctg accgaggcgg gccgcgtcac cgggctgctg gcgggctacg gctgcgccgt
    19921 gctgctcgcg ctgatggcgc gcgtccccgc gctggagcgg ggcgtcggca ccgaccggct
    19981 ggcccgctgg cacgcgatgg gcgggcgcta cacgatctcc ctgatctgcg cgcacgtgct
    20041 cctgatcatc tgggggtacg cggtgacgtc gcacaccgac gtcgtccacc agaccacctc
    20101 gatcgtcttc gattaccccg agatgctgaa gggcaccctc ggtttcctgc tgctgatcgg
    20161 cgtcggtgtc acctcggcgc gggtcgcgcg ccgcaggctc cgctacgaga tctggcacta
    20221 cctgcacttc gccacctacc tggcgatctt cctcgcgttc gggcaccagc tcgccaacgg
    20281 cgcccagttc gtctcgagcc ccctggccag ggccgcctgg tacacgctgt acatcggcgt
    20341 cgcgctggtg ctggcgtggt tccggttcgt gatgccgctc gtccgggggc tgcggcacga
    20401 cctgcgggtc gccgccgtcc ggaccgaggc ccccggcgtc gtctccgtct acatgacggg
    20461 acggcacctg gaggagctgc gcgtccagcc gggccagttc ttccggtggc ggttcctcac
    20521 ccgtggcctg tggtgggctg cgaacccgta ctcgctgtcg gagaccgccc gcggagggcg
    20581 gctccggatc accgtgaagg aggccggcga ccacagccgc gccctcgccg ggctgcgccc
    20641 cggcacgcgg gtgtgggccg agggccccta cggcggcttc accggggcgc gcccgcacca
    20701 cgaccgcgcg ctgctgctcg cgggcggtgt cggcatcacc ccgctgcgga cgctgttcga
    20761 gacgctcccc ggcgacgtcg tcctcgtcta cctggcccgc aggcccgagg acctggcgct
    20821 gcgcggcgag ctcgacgcga tcgccgccgc gcgcggctcc cgcgtcctgt acttcgtgga
    20881 cgagccggcc ggctactcgc tgccgctgac cgggcgggcg ctgcgcggcc tggtgcccga
    20941 cgtccggcac cgcgacgtgt acctgtgcgg gccgcccggg atgaccgggg ccgcgctcac
    21001 ggcgctgaag caggcgggcg tccgccgccg ccacatccgc aacgagtcgt tcgagttctg
    21061 agaggtccgt cccatgcgca gagcattgat cgccaccggg acgaccgctg ccggcgtcgt
    21121 cctgctcctc ggcctgaagc cgcaccacag cgacgtgacg ggggtctcct cgtccgcgcc
    21181 gcagagcagc gcgcccggca ccgtcggcgg ctcctcggcg gggtcgtccg gggcgtcctc
    21241 cggaacgtcc gggtcgtcgg ggggctcgtc cgcgaagacc agcggcacgt tcaagggcga
    21301 cgtcatcgac accaagtacg gcccggtgca ggtcgagatc accgcgaccg gcgggaagct
    21361 gacggccgtc cgcgtcctgc agacgccgtc ggagaacggc cgcgaccgcg agatcgccga
    21421 tttctcggtg ccgcagctga ccaaggaggc gctcgcggcg ggcaacgcgc acatcgactc
    21481 ggtgtccggc gccacctaca ccagcgaggg ctatatccgc tcgctgcaga gcgcattgga
    21541 cgccgcccgt gcctgagccc tcggtccacc acgtcgagca cgtcatgggg acggtgttct
    21601 cgttcgacgt ccgctccccg cgaacgccgg agatcaccgt ggcgctcgcg cgggccgtcg
    21661 cgtggctgca ccgcgtcgac cgcgtcttct cgccctaccg cgaggacagc cagatctccc
    21721 gtctcgcgcg aggcgagatc gacatcgccg actgcgaccc ggacgtggcc gacatcctgc
    21781 ggcgatgcgc ggagctggag cgcgagaccg gcggggcgtt cagcgccacg gcggacggcc
    21841 ggctcgaccc gagcggcctg gtgaagggct gggcgatcga gcgggcgtcc gcgatcctgc
    21901 acgaggccgg ggcccgcgac cactgcgtga acggcggcgg cgacatccag ctgcgcggcg
    21961 aggccgcgcc cggcgagccg tggcgtatcg gactcgccga tcccgcggac cccgccgcgc
    22021 tggccgccgt ggtgtccggc acggacctcg ccatcgcgac gtccggcaca gcggaacgcg
    22081 gtggccacat cgtcgacccg cgaaccgggc ggcccgccgc cgcgctggcc tcgctcacgc
    22141 tcgtcgggcg gcacatcgcc gaggtcgacg cgctcgccac cgccgcgttc gtgatgggcg
    22201 gcgcggcgcg cgagtgggcg gccgagcgtc ccggtgtcga ggcgttcgcg atcgcgcccg
    22261 accggtcccg ctggtggacg cccggcttcg agcggctggc cctgctcccc gggtaggttg
    22321 ggtggagcgt gccatatcgc cgcaatgcgt tacgaaggga acacctcatg cccagccccg
    22381 caggcgaccg gcgcgcgaag ggcggcctgg aggccgaggt cctggccgtc ctcaaggacg
    22441 ccggcgcgcc gctcaccccc cgcgaggtcg gggaacggct ggtccggccg ctcgcctaca
    22501 ccacggtgat gaccgtgc
//
