LOCUS       NZ_CP053892            22142 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4088559
            Orig. end                         :: 4110701
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..22142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="13"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22142
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12142](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(245..1891)
                     /locus_tag="ACTIVE_RS17340"
                     /old_locus_tag="ACTIVE_3462"
     CDS             complement(245..1891)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00795.1"
                     /locus_tag="ACTIVE_RS17340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3462"
                     /product="L-lactate permease"
                     /protein_id="WP_173096035.1"
                     /transl_table=11
                     /translation="MYRQVLDPVAGSLGWSSLVAALPLAVLFVLLGAVRMRAWTASLIA
                     LAVSLAVAIWTYGMPAGQAFLAGSEGAAFGFFPILWIVINALWVYNITVATGHFDVLRR
                     TFAQVSDDQRLQAILIAFSFGALLEALAGFGTPVAVTSVMLIALGFPPLKAAVLALTAN
                     TAPVAFGAMATPILTLGKVTGQSSDTLGAMVGRQTPILAVFVPLILVLIADGRRGVRET
                     WPTALFCGAAFGAAQYVTANFVSVPLADVVASLVSAAAVVLVVRLRRPHAPARPVIAGG
                     AADEPTPEFAARAGRGEAPADPRADVVRAYAPYAIIIAVFVVCQIDQVKTWLNGATQTF
                     GWPGLHITGASGKPSTLPTFTLNYFTTPGTQMLVAGLITMLALRVGAGRALRAYGTTLV
                     QLRWAIVTVMAVLALAFVMNASGQTVTLGTWMAGAGGAFAVLSPVLGWLGTAVTGSDTS
                     SNSLFGALQITAANKADLSPVLMAATNSSGGVLGKMVSPQNLAIAAAAVGLDGREGDIF
                     RRVVLWSLLFLAGMCVLSGLQSTGALSWMVP"
     misc_feature    complement(1945..1960)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            complement(2004..4061)
                     /locus_tag="ACTIVE_RS17345"
                     /old_locus_tag="ACTIVE_3463"
     CDS             complement(2004..4061)
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009080773.1"
                     /locus_tag="ACTIVE_RS17345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3463"
                     /product="xanthine dehydrogenase family protein
                     molybdopterin-binding subunit"
                     /protein_id="WP_173096036.1"
                     /transl_table=11
                     /translation="MTDRLEGREKVTGAARYAYEYPLEDPAYAAAVQSTIAKGEITEVH
                     ADAALRIPGVLAVLSCENAPHLHEVPDAELALFQSRTVSYRGQFVAVVVAETLDIAREA
                     ARHVRVDYVSEPFDARLSADDPRLYKPDTVNPVFPADTEQGDPEGAFNGSAVRVDATYT
                     TPAEHNNPMEPHTTAAQWNDDGTLTLYDSTQGASPTQETIAQVFGLDRTHVRVISPHVG
                     GGFGSKGTPRPNVVLAAMAAGAVGRPVKFAVPRQQMFATTGYRTPTIQRFRLGADADGT
                     LNSIIHEVFEQSSTLTEFAEQTATPTRVVYQAANRRTSHRLARLDVPTPSWMRAPGETP
                     GMFALESAMDELAFAAGVDPVELRIRNDTDREPESGLPFSSRNLVACLREGADRFGWEH
                     RDPAPGARREGRKLVGTGVAASTYPAYMRPNKATARADEDGTFTVRIAAADIGTGARTA
                     LTLIAAEALKADADRVTVEIGDSALPQATVAGGSAGTASWGTAVVRACESLRGKMNGSV
                     PPGGLEASADTAAELDARDEYARHAFGAQFTEVEVDADTGEVRVRRMLGVFAAGRIINP
                     KTARSQFIGGMTMGIGMALMEESVMDPRFGDYVNRDLAQYHVPACADVRDVDAAWVEEA
                     DPHLNPMGSKGIGEIGIVGAAASVANAVHHATGVRVRDLPITPARLLPLL"
     gene            complement(4058..5032)
                     /locus_tag="ACTIVE_RS17350"
                     /old_locus_tag="ACTIVE_3464"
     CDS             complement(4058..5032)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630123.1"
                     /locus_tag="ACTIVE_RS17350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3464"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_173096037.1"
                     /transl_table=11
                     /translation="MRPFVYERAATADDALQLHEDGAYYLGGGTNLVDLMRLGVEEPAR
                     LVDVSRLPYGEIELRPDGSLLIGAAVSNSDLAADRTVRESHPMLAQAVLAGASGQIRNL
                     ATVGGNLLQRTRCSYFQDADKPCNKRDPGSGCPARDGDNHNLAILGHSEACVATHPSDM
                     AVALAALDASVHVRGRGGERTIPIGDLHRLPGTEPQRDTVLESGDLITAVEVPPLDIPS
                     RYRKVRERASFAFALVSIAAALDVEGGTVRDVRIALGGVAHKPWRARRAEDALRGSPAI
                     GEEFQRAAEAELDLAEPLRDNAYKVPLARNLIVRTLTELGEQS"
     gene            complement(5029..5580)
                     /locus_tag="ACTIVE_RS17355"
                     /old_locus_tag="ACTIVE_3465"
     CDS             complement(5029..5580)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630122.1"
                     /locus_tag="ACTIVE_RS17355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3465"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_173096038.1"
                     /transl_table=11
                     /translation="MDSEVTPVHAEITLLVNGTEHRLRVDTRASLLDTLREDLGLTGSK
                     KGCDHGQCGACTVLLDGRRANACLALAVAHDGAEVVTVEGLARDGRLSALQEAFIEQDG
                     FQCGYCTPGQLCSATAVLDEAERGWPSAVTEDLRGDPVLDDDEIRERMSGNLCRCGAYM
                     GIVKAVGEAARKTQAEEAKA"
     gene            complement(5652..6164)
                     /locus_tag="ACTIVE_RS17360"
                     /old_locus_tag="ACTIVE_3466"
     CDS             complement(5652..6164)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630184.1"
                     /locus_tag="ACTIVE_RS17360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3466"
                     /product="VOC family protein"
                     /protein_id="WP_173096039.1"
                     /transl_table=11
                     /translation="MSVRGIDHVGVTVPDLEAATAFFGAVLGARPLYDTLRREDGPVAG
                     PETERRLGVPAGTEEIAMRMLRLPDGPGLELFEFRGTERRPPALPSDFGWQHVGFYVDD
                     LDAAARGVEDAGGVLLGDPQPLPGPEAGPRNRYQYARTPWGSTFELLTYPDPQPYEKEG
                     GLRRWTP"
     CDS             complement(6264..>8290)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=2
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024110.4"
                     /locus_tag="ACTIVE_RS17365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3467"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_216858463.1"
                     /transl_table=11
                     /translation="PRTVPPPPPRPEPAAPRRPSVDRNPSQIIRVAPKTLRIGRAADND
                     IVVPDLVVSRHHAELRSLGPGRHRIVDLGSHNGTYVNGNRVQSAEFTESDLLGIGHATF
                     QLVGEELREYVDTGDVSLSVEDLIVRTPEGKVILDGVGFPIPERSLVGVIGPSGAGKST
                     LLGAVTGTRPATEGTVRYDGRDLYSDYDELRHRIGLVPQEDILHTQLDTRRALLFAAEL
                     RFPGDTRKQEREQRVDEVLGELGLTAHASTRIDRLSGGQRKRVSVALELLTKPSLLFLD
                     EPTSGLDPGLDKTVMEMLAELAHDGRTVIVVTHSVANLDACDRLLVLVPGGRLAYYGPP
                     AEGLEHFGKKSWAEVFQAFDREPDRDWATEFRGSPRHARYVESGRQGGAVQADTAVPAP
                     PPRQQSRFAQLSTLCRRYLAVIASDRSYLVLLGVMPLILGGLSAAIPAPKGLTGPSPNA
                     DAASKLMVLAFAACFAGTGNAVRELVKERTIYGRERAAGLSAGVYLMSKLLVLGVITAL
                     QAVVLVLIGTIGVKLPSAGTFAPVLPELMLAMALLGVVSMTLGLLVSASVNSSEKTLPL
                     LIVLSMGQLVLSGGLVRLAGKPGLEQLAWLSPSRWGFGAAAATIDLDAIMPHTGGADPA
                     WKHAVGAWGVDLGIAAGLGVLFSALAWYRLYRLRPRRRGR"
     gene            complement(6264..>8292)
                     /locus_tag="ACTIVE_RS17365"
                     /old_locus_tag="ACTIVE_3467"
     assembly_gap    8293..8304
                     /estimated_length=12
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<8305..8660)
                     /locus_tag="ACTIVE_RS46665"
     CDS             complement(<8305..8660)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028007.4"
                     /locus_tag="ACTIVE_RS46665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FHA domain-containing protein"
                     /protein_id="WP_216858464.1"
                     /transl_table=11
                     /translation="MTAGPSAESLAAPVLVVRTRDRVHRLRPGGSYRIGRDPASDIALS
                     DPRVSWWHAVLRTGPDGWLIEDSGSSNGTFCQGGRVERMEIGGHRTFLLGHSTEGEELA
                     CFPEGPPPSRRQVYP"
     misc_feature    complement(8679..8695)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            8773..9489
                     /locus_tag="ACTIVE_RS17370"
                     /old_locus_tag="ACTIVE_3468"
     CDS             8773..9489
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022655.4"
                     /locus_tag="ACTIVE_RS17370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3468"
                     /product="DUF2993 domain-containing protein"
                     /protein_id="WP_173096040.1"
                     /transl_table=11
                     /translation="MAKPPGAAAVTRIDRLPRRRRPRWLTVLISAALLVVVLLVAADRG
                     GVLLAQHEMAVQIKKEGFPATPKVTIKGIPFLTQVVSRHFGDVRLEASRITEGPLRITN
                     LKVRARDVRVDSGFGSGTLGSVDGTAFVSFKDLASASDNPDLVLTAAGNNLVKAKMDLG
                     ITDATATATVTKQGNSIVVKTQSIEGFSRSDLGDDLDFTVPVKGLPMGLSFQSVTVSSN
                     GVGLHVTGRNVKFSDS"
     gene            complement(9508..9882)
                     /locus_tag="ACTIVE_RS17375"
                     /old_locus_tag="ACTIVE_3469"
     CDS             complement(9508..9882)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018980.4"
                     /locus_tag="ACTIVE_RS17375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3469"
                     /product="phage holin family protein"
                     /protein_id="WP_173096041.1"
                     /transl_table=11
                     /translation="MAKSRAAAKIKDDPVEENLALVRQVIDAAQQEMITKARKRVPALR
                     FGALAGALGVMATAASYRMNVQLLERKLPPELASFVTALAYGGGAGAAAMAASRRWKGL
                     PAPLPTETARQVAEIITDSG"
     gene            10001..12142
                     /locus_tag="ACTIVE_RS17380"
                     /old_locus_tag="ACTIVE_3470"
     CDS             10001..12142
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658229.1"
                     /locus_tag="ACTIVE_RS17380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3470"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_173096042.1"
                     /sec_met_domain="T1TS (E-value: 1e-77, bitscore: 261.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPFELPDFYVPYPARLNPHLQQARAHSTAWAREMGMLDDARDPG
                     TPDIWDEAALDAMDYALLCAYTHPDCDGPELDLVTDWYVWVFYFDDHFLEVFKKPQDQP
                     GARAYLDRLPEFMSLDPPEPRNAVERGLADLWARTVPARSIAWRCRFAESTDALLRESL
                     WELSNISTGRVPNPVEYVQMRRKVGGAPWSADLVEHAAGVEVPARLAGTRPLRVLKDAF
                     SDGVHLRNDIFSYQRETESEGEINNCVLVVEHFLGVAPQRAADTVNDLLTSRLRQFENT
                     ALTELPPLYEEHALTPAERAAVTAYVKGLQDWQSGGHEWHLRSSRYMNEKSLGTSASRI
                     PGLLKSARISRPHVPHQKVGPTPLPEFDMPYEARVNPHRERARRNVIEWCGAMGMFGPL
                     PRHPVPLWTAEKLAGFDFAVCAASLAPDSGAEALDLATQWLAWGTFGDDYFPAVFNRDR
                     DMAGAKLFRARIPGFMPLDCGPTPVPENPFETGLADLWHRTASPMTGRGRRQFRAAVEL
                     MVESWLWELHNHLQSRIPDPVDYLEMRRRTFGSELTMALTRIGLSHDIPDEVFATRTLH
                     EIDASAMDYACLLNDVFSYQKEIEYEGELHNGVLAVQHFLDCGRDEAVPIVNDLMASRR
                     RQFEHLATAELPALVAELGLDEAAGTALDAYVRELRDWMAGIFKWHCETHRYDEREPAG
                     EPARPLGTSAARLFTTALG"
     gene            complement(12098..12673)
                     /locus_tag="ACTIVE_RS17385"
                     /old_locus_tag="ACTIVE_3471"
     CDS             complement(12098..12673)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS17385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_3471"
                     /product="hypothetical protein"
                     /protein_id="WP_173096043.1"
                     /transl_table=11
                     /translation="MPDWRDRFAAAPLWVIALVSAALVAAYFDAIALAGGEPARSLPKF
                     SLAGGGIAVLVTAVAAVNRWWVHRVAGRHPRDARVSMAAAFRTGRPPTDPALDGPLLAL
                     IERRKADRARLRRWRPAVVVLLIVWCGLGLYVDLVDWRPPVVVLVLILAVLVPLQRRQR
                     NRYRLLEERIRARGSAEGRREEAGRGGS"
     gene            12987..15026
                     /locus_tag="ACTIVE_RS17390"
                     /old_locus_tag="ACTIVE_3472"
     CDS             12987..15026
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020906.4"
                     /locus_tag="ACTIVE_RS17390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3472"
                     /product="DUF1990 family protein"
                     /protein_id="WP_173096044.1"
                     /transl_table=11
                     /translation="MGAGIALWRWLRTARTTHRGRLATGPGFEPARIPDRGGDRVQGLR
                     QGVGPAYQRRYTVRIVGSPLDAPRLMERLRADVNAASPVEFAVFDKVSGASPRLDLDDE
                     YDVHMPGPWDCPVRVVERAPLSFRFATLEGHVEAGEIEFRARDTGDGEVEFTIESWTRS
                     GDRLADVLYDRLGMAKEMQLHMWTHFCCRVAEMSGGRMAGEVEVRTERTEIAGDPRVDA
                     HRLTGPAGAALARAFTAAARARGGRPLHPHGLVFDATLRLSGTSRFWGVPLLDDAAELR
                     GVARLSRSIGLPSPFPDVLGLALRWRQPEEDGEPATAELLLATTGHGRLGRHLLRPANR
                     WGPGFYGSLLPYAAGDRRVLLGAVARRAVPADPAAADGPITMDLVVAAGLGPWERFGEL
                     LLTGPVRTDDREPLRFDPVRHPVPGLRPAGALQQMRGRAYDAVQHVDEHPRAGRAVTGR
                     RGAVPRRRPRAHRRLQRLYEGLRERPVNFAPGDRPEHAGTGGWHMDDRRQALPPERPGP
                     PEPDGSWEIARRLVRDYEFADPRIIRSAYRRSAPAPGADMLLEGRFFGLRFPLGVRVGD
                     VVDTTTEQDGRPVRVWGWNYRTLEGHLERGQMDQEVRKWLDTGDVEFRLRAFSHRAPIR
                     NPVVRLGFELFGRPTQLVYQRRACRRMAHLTRTELAARRPAPAE"
     gene            complement(15040..15567)
                     /locus_tag="ACTIVE_RS17395"
                     /old_locus_tag="ACTIVE_3473"
     CDS             complement(15040..15567)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630119.1"
                     /locus_tag="ACTIVE_RS17395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3473"
                     /product="NADAR family protein"
                     /protein_id="WP_173096045.1"
                     /transl_table=11
                     /translation="MDVQQLIRLHEEGARPKYLFFWGHRKPGPGYLSQWWPSPFTVGDV
                     TYATAEHYMMAEKARLFGDGETAAAVIDAPHPGAAKDLGRRVRGFDDDAWTARRAEIVV
                     AGNRAKFEQNPELRDYLAGTRDRVLVEASPLDRVWGIGLAADDPRAQEPAEWQGLNLLG
                     FALMTVRESLAG"
     misc_feature    15664..15679
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.8"
                     /tool="antismash"
     misc_feature    15677..15690
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.33"
                     /tool="antismash"
     gene            15779..15910
                     /locus_tag="ACTIVE_RS48185"
                     /old_locus_tag="ACTIVE_3474"
     CDS             15779..15910
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658238.1"
                     /locus_tag="ACTIVE_RS48185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3474"
                     /product="hypothetical protein"
                     /protein_id="WP_281382859.1"
                     /transl_table=11
                     /translation="MDNALANPRRTRISSWPQRPADADTERPLDAEPTAPEDDLAAR"
     gene            complement(15992..17050)
                     /locus_tag="ACTIVE_RS17400"
                     /old_locus_tag="ACTIVE_3475"
     CDS             complement(15992..17050)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017602774.1"
                     /locus_tag="ACTIVE_RS17400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3475"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_173096046.1"
                     /transl_table=11
                     /translation="MTEAAEEPRTGERAYVTLQDVARRAEVSLATASRVLNGTSQVRAD
                     LRERVLAAAAELGYTPNAHAQALAGSSSKAVGVICHDVSDPYFAAVARGVMRTAAEHGM
                     LVMLASTFRDASREIEYVAMLRAQRARAILLIGSGFEDREWERRMAAELEPYQRTGGRV
                     AVLSRHRSLKVDAVLPQNREGAGALARALLDLGHRDFGVLSGPRALTTVSDRLGGFTEA
                     LADAGIAVPEEHIVEESFTRDGGYRAATELLRRTPRPTCVFAVTDVMAIGALAALRDHG
                     VAVPGEMSLAGFDDIPIVRDLTPPLTTVALPLEAMGEHVMGLALREPAARRSRLERVAG
                     HVILRESTAPPR"
     misc_feature    complement(17194..17205)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            17241..18167
                     /locus_tag="ACTIVE_RS17405"
                     /old_locus_tag="ACTIVE_3476"
     CDS             17241..18167
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017544144.1"
                     /locus_tag="ACTIVE_RS17405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3476"
                     /product="ABC transporter permease"
                     /protein_id="WP_173096047.1"
                     /transl_table=11
                     /translation="MVSQHLSRGDDPPRSPNRSPRGPGTAAATPAADTAGVVERARPSA
                     GERLAGALESAWRPVALLVACFAAWWAVTAFKLVEAYLVPSPWTTLKLMGDKWGYIWHH
                     TWVTTYETLIGFALAVVIGVAAAVLMVYSGTVERTLYPILLFAQVIPKIAIAPLFVVWL
                     GFGIGPKIVVAVLIAFFPVVISMVAGLKAVDPEMLQLSSTMGASAFATFTKIRLPASLP
                     HLFSGLKVAVTLAVTGAVVGEFVGANEGLGYVILQANGNIDTPMLFAGLLVMSAIGVVL
                     FVAVEIAEKLLLPWHASRRGESVTTTY"
     gene            18250..19272
                     /locus_tag="ACTIVE_RS17410"
                     /old_locus_tag="ACTIVE_3477"
     CDS             18250..19272
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631475.1"
                     /locus_tag="ACTIVE_RS17410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3477"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_173096048.1"
                     /transl_table=11
                     /translation="MKLRILAVTALVPAVALAAAACGGDSGETTGASGKKLKKVTLTLN
                     WYPYGEHAPFYYGKKKGIYEKHGIDLEIKAGQGSQKTVQATGAGQTDFGWADTPALLAA
                     VDKGMPIKSIGVFLQTTPASVQAFSSKNLKAPADLKGKKIAITAGDALSRTFPVFLKKN
                     GLSEGDVPLQNTDPAGKIAAVISGKADGLVGFANDQGPTVANKSGKPVSYLRYSDFGVN
                     FFSNGLLAGERKLKSDAGLVKDMVAATSEAWSAAEADPQGAVASMAGASEQLPPTPVVA
                     EQFKTTLTLLHTQATQGKAPGVNTEDDWKQTITLFQQTGVIGKAEAPSKYWSPQLAAQG
                     "
     gene            19293..20108
                     /locus_tag="ACTIVE_RS17415"
                     /old_locus_tag="ACTIVE_3478"
     CDS             19293..20108
                     /EC_number="7.6.2.7"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631474.1"
                     /locus_tag="ACTIVE_RS17415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3478"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_246342934.1"
                     /transl_table=11
                     /translation="MSEPGKAAAERASAVRIDEVAVRFRSKKREVTALREVSLDVPMGE
                     FVAIVGPSGCGKSTMLKLVAGLLKPSTGTVRLNGEQVAGPRADIGYVFQRAALLEWRSA
                     RKNILLQAEMRKMPAEQARKRTAELIEMTGLTGFEDALPHELSGGMQQRVALCRALLHE
                     PPVLLMDEPFGALDALTREQLNIEMNRIWRETGTTVLLVTHSVAEAAYLANRVVVMTDR
                     PGSIAEVIDVDLPPERDYAQTMAQPEFARVTGRIRTLLGAGAGAGAALD"
     gene            20146..21294
                     /locus_tag="ACTIVE_RS17420"
                     /old_locus_tag="ACTIVE_3479"
     CDS             20146..21294
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631473.1"
                     /locus_tag="ACTIVE_RS17420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_3479"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_173096050.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 8e-09, bitscore:
                     35.3, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.3e-22,
                     bitscore: 79.1, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARKSIGIVMNGVTGRMGYRQHLLRSILAIREQGGLRLADGTDLW
                     PEPVLVGRSEAKLRDLAARHGLDAWTTDLDEALARPGVEVYFDAQVTGARVAAIRKAVA
                     AGKHVYTEKPLADDLEGALALAKLADESGIKHGVVQDKLFLPGLLKLKRLIDGGFFGRI
                     LSVRGEFGYWVFEGDWQEAQRPSWNYRAEDGGGIILDMFCHWRYVLDAIAQVRSVQALG
                     ATHVPERVDEDGKPYEATADDAAYGIFELDGGIVAQINSSWTTRVFRDELVEFQVDGTE
                     GSAVAGLRRCRVQHRSMTPKPVWNPDLPATEDFRAQWQEIPDNTVFDNGFKTQWEMFLR
                     HVTEDAPFSWDFYAGARGVQLAELGLQAWREGRRIEVPELRR"
     misc_feature    complement(21578..21589)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.79"
                     /tool="antismash"
ORIGIN
        1 agaaggcgat cctggagcgg atccacgagt tcatcgacga ggagcacgcg ctccggcagg
       61 cgcatgagcg gtcggagacc tccggtgagg acgcccggca gcggctgcgg gagctggagg
      121 tggccctcga ccagtgctgg gacctgctgc gccagcggcg cgcgcggatc gaggcgggcc
      181 agaaccccga ggaggcgcgg gtgcgcccgg cgagcgaggt cgagggctac cgccagtagc
      241 ccgttcacgg caccatccag gacagcgcgc cggtggactg cagtcccgac aggacgcaca
      301 tgccggcgag gaacagcagg ctccacagca cgacgcggcg gaagatgtcg ccctcgcggc
      361 cgtccagccc gacggcggcc gcggcgatcg cgaggttctg cggcgacacc atcttcccga
      421 ggacgccgcc ggagctgttg gtggcggcca tcaggacggg cgacaggtcg gccttgttcg
      481 cggcggtgat ctgcagggcg ccgaacaggg agttggacga ggtgtccgag ccggtcacag
      541 cggtgccgag ccagccgagg accggggaca gcacggcgaa ggcgccgccg gcgcccgcca
      601 tccaggtgcc gagggtgacg gtctggccgg aggcgttcat cacgaacgcg agcgccagca
      661 cggccatgac ggtgacgatc gcccagcgga gctggacgag cgtggtgccg taggcgcgca
      721 gcgcccggcc cgccccgacg cgcagcgcga gcatggtgat gaggcccgcg accagcatct
      781 gcgtgccggg cgtggtgaag tagttgaggg tgaaggtggg cagcgtcgac ggtttgccgg
      841 acgcgcccgt gatgtgcagg ccgggccagc cgaacgtctg cgtggcgccg ttcagccagg
      901 tcttgacctg gtcgatctgg cagacgacga acaccgcgat gatgatcgcg tagggggcgt
      961 aggcgcggac gacgtcggcg cgcgggtcgg cgggcgcctc gccgcgcccg gcgcgggcgg
     1021 cgaactcggg ggtcggctcg tcggcggcgc cgccggcgat gaccgggcgg gccggcgcgt
     1081 gcgggcggcg cagccggacg acgaggacga ccgcggcggc cgacaccagc gacgcgacga
     1141 cgtcggcgag cggcaccgag acgaagttgg cggtgacgta ctgcgcggcg ccgaacgcgg
     1201 cgccgcagaa cagcgcggtc ggccacgtct cgcggacgcc gcgccggccg tcggcgatca
     1261 gcaccaggat cagcgggacg aacacggcga ggatcggggt ctgccggccg accatggcgc
     1321 cgagcgtgtc gctggactgg ccggtgacct tgccgagggt gaggatcggg gtggccatcg
     1381 cgccgaacgc gaccggcgcg gtgttggcgg tgagcgcgag gacggcggcc ttgagcggcg
     1441 ggaagccgag cgcgatcagc atcacggagg tgaccgcgac cggggtgccg aacccggcca
     1501 gcgcctccag cagcgcgccg aacgagaacg cgatgaggat cgcctgcagc cgctggtcgt
     1561 cgctgacctg cgcgaacgtg cggcgcagca cgtcgaagtg gccggtcgcg acggtgatgt
     1621 tgtagaccca gagcgcgttg atgacgatcc acaggatcgg gaagaagccg aacgcggcgc
     1681 cttcgcttcc ggccaggaac gcctgcccgg ccggcatccc gtacgtccag atcgcgacgg
     1741 ccagggagac ggccagcgcg atcagggacg ccgtccaggc gcgcatccgg acggcgccga
     1801 gcagcacgaa cagcaccgcc agcggcagcg cggcgaccag cgaactccag ccgagcgagc
     1861 cggcgacggg atcgaggacc tgtcggtaca cgggatcacc tcgcataggg agcggccccc
     1921 gagtagacga tcaatacccc gcgatgtggc ccgtctcaca tgaatggtga acttttcaac
     1981 cagtcagggc ccggccggcc ccgtcagagc aggggcagca gccgggccgg ggtgatcggc
     2041 aggtcgcgga cgcggacgcc ggtcgcgtgg tgcacggcgt tcgcgacgga cgcggcggcg
     2101 cccacgatcc cgatctcgcc gatgcccttg gaccccatcg ggttcaggtg cgggtcggcc
     2161 tcctccaccc acgccgcgtc gacgtcgcgg acgtccgcac aggccggcac gtggtactgg
     2221 gcgaggtcgc ggttgacgta gtcgccgaac cgcgggtcca tgacgctctc ctccatcagc
     2281 gccatgccga tccccatcgt catgccgccg atgaactgcg accgcgcggt cttcgggttg
     2341 atgatccggc ccgcggcgaa cacgccgagc atccggcgga cccggacctc gccggtgtcg
     2401 gcgtccacct ccacctcggt gaactgcgcg ccgaacgcgt gccgcgcgta ctcgtcgcgg
     2461 gcgtcgagct ccgcggcggt gtcggcggac gcctccagcc cgccgggcgg cacggacccg
     2521 ttcatcttgc cgcgcagcga ctcgcaggcg cggacgacgg cggtgcccca gctcgccgtg
     2581 ccggcggagc cgcccgcgac ggtcgcctgc ggcagcgcgc tgtcgccgat ctccacggtc
     2641 acccggtcgg cgtcggcctt gagcgcctcg gcggcgatca gcgtgagcgc ggtgcgggcg
     2701 ccggtgccga tgtcggcggc ggcgatccgg acggtgaacg tcccgtcctc gtcggcgcgc
     2761 gcggtggcct tgttcggccg catgtaggcc gggtaagtgg acgcggcgac gcccgtcccg
     2821 acgagcttgc ggccctcccg gcgggccccg ggcgcggggt cgcggtgctc ccagccgaac
     2881 cggtcggcgc cctcgcgcag gcacgcgacg aggttgcggg agctgaacgg cagcccgctc
     2941 tccggctcgc ggtcggtgtc gttgcggatc cgcagctcga ccgggtcgac gccggcggcg
     3001 aacgccagct cgtccatcgc cgactccagc gcgaacatgc cgggcgtctc gccgggcgcc
     3061 cgcatccatg acggcgtcgg gacgtcgagg cgggcgagcc ggtgcgaggt gcgccggttg
     3121 gccgcctggt acaccacgcg ggtcggcgtc gcggtctgct cggcgaactc ggtgagggtg
     3181 gaggactgct cgaacacctc gtggatgatc gagttcagcg ttccgtcggc gtcggcgccg
     3241 agccggaacc gctggatcgt cggcgtccgg tagccggtgg tggcgaacat ctgctggcgc
     3301 ggcaccgcga acttcaccgg gcggcccacc gcgcccgccg ccatcgccgc gagcaccacg
     3361 ttgggccgcg gcgtgccctt ggagccgaac ccgccgccga cgtgcgggga gatgacgcgc
     3421 acgtgggtgc ggtcgaggcc gaacacctgg gcgatggtct cctgcgtcgg cgacgcgccc
     3481 tgcgtggagt cgtagagcgt gagggtgccg tcgtcgttcc actgggccgc ggtcgtgtgc
     3541 ggctccatcg ggttgttgtg ctcggccggc gtcgtgtacg tggcgtccac ccggaccgcg
     3601 gagccgttga aggcgccctc cgggtcgccc tgctcggtgt cggccgggaa caccgggttc
     3661 accgtgtcgg gcttgtagag gcgcgggtcg tccgcgctga gccgcgcgtc gaacggctcg
     3721 gacacgtagt cgacgcggac gtgccgcgcc gcctcccgcg cgatgtccag cgtctcggcg
     3781 acgaccaccg cgacgaactg gccccggtag gagaccgtcc gggactggaa cagcgccagc
     3841 tccgcgtccg ggacctcgtg caggtgcggc gcgttctcgc aggacaggac ggccaggacg
     3901 cccgggatcc gcagcgccgc gtccgcgtgc acctccgtga tctcgccctt ggcgatcgtc
     3961 gactgcacgg ccgcggcgta cgctgggtcc tccagcgggt actcgtaggc gtagcgggcc
     4021 gccccggtga ccttctcgcg gccctccagc cggtcggtca tgactgctcc cccagctcgg
     4081 tcagcgtccg gacgatcagg ttgcgcgcga gcggcacctt gtaggcgttg tcgcgcagcg
     4141 gctcggcgag gtccagctcg gcctcggcgg cgcgctggaa ctcctcgccg atcgccgggg
     4201 agccgcgcag cgcgtcctcg gcgcggcgtg cccgccacgg cttgtgcgcg acgccgccga
     4261 gcgcgatccg cacgtcccgg acggtgccgc cctccacgtc gagcgccgcc gcgatcgaca
     4321 ccagcgcgaa cgcgaacgac gcgcgctcgc ggaccttgcg gtaccgggac gggatgtcca
     4381 gcggcggcac ctccacggcc gtgatgaggt cgccgctctc cagcaccgtg tcgcgctgcg
     4441 gctcggtgcc gggcagccgg tgcaggtcgc cgatcgggat cgtccgctcg ccgccgcggc
     4501 cccggacgtg cacgctcgcg tcgagcgcgg cgagcgccac cgccatgtcg gacgggtggg
     4561 tcgcgacgca cgcctcggag tggccgagga tcgcgaggtt gtggttgtcg ccgtcccggg
     4621 ccgggcaacc gctgcccggg tcccgcttgt tgcacggctt gtcggcgtcc tggaagtagg
     4681 agcagcgcgt ccgttgcagc aggttgccgc ccacggtcgc gaggttgcgg atctggccgg
     4741 acgccccggc caggacggcc tgcgccagca tcgggtggct ctcgcgcacc gtccggtccg
     4801 cggcgaggtc gctgttgctg acggcggcgc cgatgagcag gctcccgtcc ggccgcagct
     4861 cgatctcgcc gtagggcagg cgggacacgt cgacgaggcg ggccggctcc tccacgccga
     4921 gcctcatcag gtcgacgagg ttggtgccgc cgcccaggta gtaggcgccg tcctcgtgca
     4981 gctgcagggc gtcgtcggcg gtggcggcgc gctcgtacac gaagggcctc atgccttggc
     5041 ctcttccgcc tgcgtcttgc gcgccgcctc accgaccgcc ttgacgatgc ccatgtacgc
     5101 gccgcaccgg cacaggttgc cgctcatgcg ctcgcgtatc tcgtcgtcgt cgaggacggg
     5161 atcgccgcgc aggtcctcgg tcaccgcgct cggccagccg cgctccgcct cgtcgagcac
     5221 ggccgtcgcg gagcagagct ggccgggcgt gcagtacccg cactggaagc cgtcctgctc
     5281 gatgaacgcc tcctgcagcg cgctgagccg gccgtcccgc gcgagcccct cgaccgtgac
     5341 gacctccgcg ccgtcgtgcg cgacggcgag cgccaggcac gcgttcgccc ggcggccgtc
     5401 cagcaggacg gtgcacgcgc cgcactgccc gtggtcgcag cccttcttgg aaccggtcag
     5461 cccgaggtcc tcgcgcagcg tgtccagcag cgacgcgcgc gtgtcgacgc ggagccggtg
     5521 ctcggtcccg ttcacgagca gcgtgatctc ggcatgtacc ggggtgactt cgctgtccat
     5581 gccccggccc ctaccccgtt cgccggtgag cagtcagttc acccctgagc ggccggttcg
     5641 ccgccgggcg gtcagggcgt ccagcggcgc aggccgccct ccttctcgta gggctgcgga
     5701 tcggggtagg tcagcagctc gaaggtgctg ccccacggcg tccgcgcgta ctggtaccgg
     5761 ttgcgggggc cggcctcggg gccgggcagc ggctgcgggt cgccgagcag cacgccgccc
     5821 gcgtcctcga cgccgcgcgc cgccgcgtcg aggtcgtcca cgtagaaccc gacgtgctgc
     5881 cagccgaagt cgctcggcag cgcgggcggg cggcgctcgg tgccgcggaa ctcgaacagc
     5941 tccaggcccg ggccgtccgg cagccgcagc atccgcatcg cgatctcctc ggtgcccgcg
     6001 ggcacgccga ggcgccgctc ggtctccggc ccggcgaccg gcccgtcctc ccgccgcagc
     6061 gtgtcgtaca gcgggcgcgc cccgaggacg gcgccgaaga acgcggtggc cgcctccagg
     6121 tccgggacgg tcacccccac atggtcgatc cccctcacgc tcataccgct gggaatgccc
     6181 ggaggtcccc cggccaaccc gtggcgccgg tcacgtgacc agcggcgacg ccgccggcgg
     6241 cgggtcgacg gatcggcggc gggtcagcgg ccgcggcggc gcgggcggag ccggtagagg
     6301 cggtaccagg ccagcgcgga gaacaggacg ccgagcccgg ccgcgatgcc gaggtccacg
     6361 ccccaggcgc ccacggcgtg cttccacgcc gggtcggcgc cgcccgtgtg cggcatgatc
     6421 gcgtcgaggt cgatggtcgc ggcggccgcg ccgaaccccc agcgcgacgg cgacagccac
     6481 gccagctgct ccagacccgg cttgcccgcg agccgcacca gcccgccgga cagcacgagc
     6541 tgccccatcg acagcacgat cagcagcggc agcgtcttct ccgagctgtt caccgacgcc
     6601 gacaccagca gccccagcgt catcgacacc acgccgagca gcgccatcgc gagcatcagc
     6661 tccggcagca cgggcgcgaa cgtcccggcg gacggcagct tcacgccgat cgtcccgatc
     6721 agcaccagca cgaccgcctg cagcgccgtg atcaccccga ggaccagcag cttcgacatc
     6781 aggtacacgc ccgccgacag ccccgcggca cgctcccggc cgtagatcgt ccgttccttc
     6841 accagctccc ggacggcgtt gccggtgccc gcgaagcacg ccgcgaacgc cagcaccatc
     6901 agcttggacg cggcgtcggc gttcggcgag ggccccgtca gccccttcgg cgcggggatc
     6961 gcggcgctca gcccgccgag gatcagcggc atcaccccga gcagcaccag gtagctgcgg
     7021 tcggacgcga tcaccgcgag gtagcgccgg cacaacgtgc tgagctgcgc gaaccgggac
     7081 tgctgccgcg gcggcggcgc gggcaccgcc gtgtcggcct ggacggcgcc gccctgccgg
     7141 ccgctctcca cgtaccgggc gtggcgcggc gacccgcgga actcggtggc ccagtcgcgg
     7201 tccggctccc ggtcgaacgc ctggaacacc tccgcccacg acttcttccc gaagtgctcc
     7261 agcccctcgg cgggcggccc gtagtaggcg agccggccgc ccggcaccag cacgagcagc
     7321 cggtcgcagg cgtccaggtt cgcgacgctg tgcgtgacga cgatgaccgt ccggccgtcg
     7381 tgcgccagct ccgccagcat ctccatgacc gtcttgtcca ggcccgggtc gaggccggac
     7441 gtcggctcgt ccaggaacag cagcgacggc ttggtcagca gctccagggc gacgctgacc
     7501 cgcttgcgct gcccgcccga cagccggtcg atgcgggtcg aggcgtgcgc ggtcaggccc
     7561 agctcgccga gcacctcgtc gacccgctgc tcgcgctcct gcttgcgcgt gtcgccgggg
     7621 aagcgcagct cggcggcgaa cagcagcgcc cgccgcgtgt cgagctgggt gtgcaggatg
     7681 tcctcctgcg ggacgagccc gatgcggtgc cgcagctcgt cgtagtcgga gtacaggtcg
     7741 cggccgtcgt agcggaccgt cccctcggtc gccgggcgcg tgccggtgac ggcaccgagc
     7801 agcgtggact tgcccgcgcc ggacgggccg atcaccccga ccagcgagcg ctccgggatc
     7861 gggaagccga ccccgtccag gatcaccttg ccctcgggcg tccggacgat caggtcctcc
     7921 accgacagcg acacgtcgcc ggtgtcgacg tactcccgca gctcctcgcc gaccagctgg
     7981 aacgtcgcgt gcccgatgcc gagcaggtcg ctctcggtga actccgccga ctggacccgg
     8041 ttgccgttga cgtaggtccc gttgtggctg ccgaggtcga cgatccggtg ccgtccgggg
     8101 ccgaggctgc gcagctccgc gtggtgccgc gacaccacca ggtcgggcac gacgatgtcg
     8161 ttgtcggcgg cgcggccgat ccgcagcgtc ttcggcgcga cccggatgat ctggctgggg
     8221 ttgcggtcga cgctcggccg gcgcggcgcg gccggttccg gccgcggggg cgggggcggc
     8281 accgtgcggg gcnnnnnnnn nnnngggtac acctggcggc ggctcggcgg cgggccctcc
     8341 gggaagcagg ccagttcctc gccctcggtc gagtggccga gcaggaacgt ccggtgcccg
     8401 ccgatctcca tccgctcgac gcggccgccc tggcagaacg tgccgttgct gctgccggag
     8461 tcctcgatca gccagccgtc cgggcccgtc cgcagcaccg cgtgccacca cgagacgcgc
     8521 ggatccgaca gcgcgatgtc ggacgcgggg tcgcggccga tgcggtagga gccccccggg
     8581 cgcagccggt gcacccggtc ccgcgtgcgg acgacgagaa cgggcgcggc gagcgattcg
     8641 gcggaaggtc cggccgtcat gcggggagtg taagtcctcg ccccggaaat gtcccggccc
     8701 gtttttccgc ccggcattcc cgggactccg gtcccattga cagggcccct ccgcgggaat
     8761 tgagtgaacg ccatggcgaa accgccgggc gcggccgccg tcacccggat cgaccgcctt
     8821 ccgcggcggc gccggccacg gtggctcacc gtcctgatca gcgccgccct gctggtcgtg
     8881 gtgctccttg tggccgcgga ccggggcggt gtcctgctcg cgcagcacga gatggccgtg
     8941 cagatcaaaa aggagggatt cccggcgaca ccgaaagtga cgatcaaggg aatcccgttc
     9001 ctcacccagg tggtgtcccg tcacttcggc gatgtgcggc tcgaggcgag cagaatcacc
     9061 gagggcccct tgcgcatcac gaacctcaaa gtgcgcgcgc gggacgtccg ggtcgattcc
     9121 gggttcggta gcggcacgct cggcagcgtg gacggcaccg cgttcgtcag cttcaaggac
     9181 ctcgcgagcg cgagcgacaa ccccgacctc gtgctgaccg ccgccggcaa caacctggtg
     9241 aaggccaaga tggacctcgg catcaccgat gcgaccgcca ccgcgaccgt caccaagcag
     9301 gggaacagca tcgtggtgaa gacccagtcg atcgaggggt tctcgcgctc cgacctcggc
     9361 gacgacctcg acttcaccgt cccggtgaag ggcctgccga tggggctgtc gttccagagc
     9421 gtgacggtct cgtcgaacgg cgtcggcctg cacgtgaccg gccggaacgt gaagttcagc
     9481 gactcgtgac ccgccggcgg gcggacgtca gccggaatcg gtgatgatct cggcgacctg
     9541 ccgggccgtc tcggtcggca gcggcgcggg cagccccttc cacctgcggg acgccgccat
     9601 cgcggccgcg cccgccccgc ccccgtacgc cagcgccgtg acgaacgacg ccagctccgg
     9661 cggcagcttg cgctccagca gctgcacgtt catccggtag gacgccgcgg tcgccatgac
     9721 cccgagcgcc cccgccagcg cgccgaaccg cagtgcgggc acccgcttgc gcgccttggt
     9781 gatcatttcc tgctgcgcgg cgtcgatcac ctgccggacg agtgccaggt tctcctccac
     9841 cggatcgtcc ttgatcttcg ccgccgctcg cgacttggcc atgaccccgg cttacccgct
     9901 gcattgcgaa ggattcgagg gagcagatgt ctcactgtaa gtaactttgc cgctcctgta
     9961 ggttgcgaag cgtccccgag caggaaggcg tgtccggtcg atgcaaccgt tcgagctgcc
    10021 cgacttctac gtcccgtatc cggcccggct gaacccgcac ctgcagcagg cgcgcgcgca
    10081 cagcacggcc tgggcccggg agatgggcat gctcgacgac gcccgcgacc ccggcacccc
    10141 cgacatctgg gacgaggccg cgctcgacgc gatggactac gcgctcctgt gcgcctacac
    10201 ccatcccgac tgcgacggcc ccgaactcga cctcgtcacc gactggtacg tctgggtctt
    10261 ctacttcgac gaccacttcc tcgaggtgtt caagaagccg caggaccagc ccggcgcccg
    10321 cgcctacctc gaccggctcc cggagttcat gtcgctcgac ccgcccgagc cgcgcaacgc
    10381 cgtcgagcgc ggcctcgccg acctgtgggc gcgcaccgtg cccgcccggt ccatcgcctg
    10441 gcggtgccgg ttcgccgaga gcaccgacgc gctgctgcgc gagtcgctgt gggagctgtc
    10501 caacatcagc accgggcgcg tcccgaaccc cgtcgagtac gtgcagatgc gccgcaaggt
    10561 cggcggcgcc ccctggtcgg cggacctcgt cgagcacgcc gccggcgtcg aggtccccgc
    10621 ccggctcgcc ggcacccggc cgctgcgcgt gctcaaggac gccttctccg acggcgtcca
    10681 cctgcgcaac gacatcttct cctaccagcg cgagacggag tccgaaggcg agatcaacaa
    10741 ctgcgtcctg gtcgtcgagc acttcctcgg cgtcgcgccg cagcgcgccg ccgacaccgt
    10801 caacgacctg ctcacctcgc ggctgcgcca gttcgagaac accgccctca ccgaactccc
    10861 cccgctctac gaggagcacg cgctcacccc cgccgaaagg gccgccgtca ccgcctacgt
    10921 gaagggcctc caggactggc agtccggcgg ccacgaatgg catctgcgct ccagccggta
    10981 catgaacgag aagtccctcg gaacgtcggc ctcgcgcatc cccggcctgc tcaagtcggc
    11041 ccggatcagc cgcccgcacg ttccgcacca gaaggtcggc ccgacgcccc tgccggaatt
    11101 cgacatgccg tacgaggccc gcgtgaaccc gcaccgggaa agggcgcggc ggaacgtcat
    11161 cgagtggtgc ggagccatgg gcatgttcgg cccgctcccc cgccatcccg tcccgctctg
    11221 gacggcggag aagctcgcgg gattcgactt cgcggtctgc gccgcgtccc tcgcccccga
    11281 ctccggcgcc gaggcgctcg acctcgccac gcagtggctg gcctggggca ccttcggcga
    11341 cgactacttc cccgccgtct tcaaccgcga ccgcgacatg gccggcgcga agctgttccg
    11401 cgcccggatc cccggtttca tgccgctgga ctgcgggccc acgcccgtcc cggagaaccc
    11461 cttcgagacc ggcctcgccg acctgtggca ccgcaccgcg tcgcccatga ccggacgcgg
    11521 ccgccgccaa ttccgtgccg ccgtcgagct catggtcgag agctggctct gggaactgca
    11581 caaccatctc cagtcccgca ttcccgaccc cgtcgactac ctcgagatgc ggcggcgcac
    11641 cttcgggtcc gagctcacca tggcgctgac ccgcatcggc ctctcccacg acatccccga
    11701 cgaggtcttc gccacccgca ccctgcacga gatcgacgcg tccgcgatgg actacgcctg
    11761 cctcctcaac gacgtcttct cctaccagaa ggagatcgag tacgagggcg agctgcacaa
    11821 cggcgtcctc gccgtccagc atttcctcga ctgcgggcgg gacgaggccg tccccatcgt
    11881 caacgacctc atggcgtcgc gccgccgcca gttcgagcac ctcgccaccg ccgaactccc
    11941 cgccctggtg gccgaactgg gcctcgacga ggcggccggc accgccctcg acgcttacgt
    12001 ccgcgaactg cgggactgga tggcgggcat cttcaaatgg cactgcgaga cgcaccgcta
    12061 cgacgagcgc gaacccgccg gggaaccggc gcgcccgcta ggaacctccg cggcccgcct
    12121 cttcacgacg gccctcggct gacccgcgcg cacggatgcg ctcctccagc agccggtacc
    12181 tgttccgctg acgccgctgc agaggcacca ggacagccag gatgagcacg agaacgacga
    12241 caggcggacg ccagtcgacg aggtccacgt agagacccag cccgcaccag acgatgagca
    12301 ggacgacgac ggcgggccgc cagcggcgca gccgggcccg gtccgccttg cggcgctcga
    12361 tgagcgcgag gagcggcccg tccagggccg gatcggtcgg cggcctcccg gtgcggaacg
    12421 ccgcggccat ggagacccgc gcgtcgcggg ggtgcctgcc ggcgacacgg tgcacccacc
    12481 accggttcac cgccgcgacg gcggtgacca gcaccgcgat gccgccgccg gccagcgaga
    12541 acttcggcag gctccgcgcg ggctcgccgc cggcgagcgc gatcgcgtcg aagtacgccg
    12601 ccaccagggc ggcggagacc agcgcgatca cccagagcgg cgccgccgcg aaacgatctc
    12661 tccagtcggg cacgggacca ccgtccacca ccgggcgccc gcacagcgcg agatgaccgc
    12721 acccggccgc acggcgccgc gccctgccga tcagccgggc cggacggcgg cgaggtcctt
    12781 gcgggacagc acgccgagcc tgggatacac cttggtgagg tggtggccga ccctccgggg
    12841 gccgaggacg cgcgcgggtt gggcgccggc ccggcgggta gggcgcgacc tgcacgaaca
    12901 cacgcatcgt gagggcgagg cgcgagtcgt cggggggcgc cgtgcggaga cgttggcgga
    12961 ggcgtgcgcg ggcggcgcgc tggccggtgg gggcgggcat cgcgctctgg cggtggctcc
    13021 ggacggcccg cacgacgcac cggggacggc tcgcgacggg gccgggtttc gagccggcgc
    13081 ggatccccga ccgcggcggc gaccgggtcc aggggctgcg gcagggggtc ggcccggcgt
    13141 accagcgccg ctacacggtc cggatcgtcg gcagccccct ggacgcgccg cggctgatgg
    13201 agcggctgcg cgccgacgtc aacgccgcct cgccggtcga gttcgccgtc ttcgacaagg
    13261 tctcgggggc ctcaccgcgg ctggacctcg acgacgagta cgacgtgcac atgcccgggc
    13321 cgtgggactg cccggtgcgg gtcgtggagc gggcgccgct gtccttccgg ttcgcgacgc
    13381 tggaggggca cgtcgaggcc ggcgagatcg agttccgggc gcgcgacacc ggggacggcg
    13441 aagtcgagtt caccatcgag tcgtggacgc gcagcggcga ccggctggcg gacgtcctct
    13501 acgaccggct ggggatggcg aaggagatgc agctccacat gtggacgcat ttctgctgcc
    13561 gggtggcgga gatgtccggc ggccggatgg ccggggaggt cgaggtccgc accgagcgga
    13621 ccgagatcgc cggggacccg cgggtcgacg cgcaccgcct gaccgggccg gcgggcgccg
    13681 cgctcgcccg ggcgttcacc gcggcggcga gggcgcgcgg cgggcggccg ctgcatcccc
    13741 acgggctcgt cttcgacgcc acgctgcgcc tgtcgggcac gtcgcgtttc tggggcgtcc
    13801 cgctgctgga cgacgcggcg gagctgcggg gcgtggcgcg gctgtcgcgg tcgatcgggc
    13861 tgccgtcccc gttccccgac gtcctcgggc tggcgctgcg ctggcggcag cccgaggagg
    13921 acggcgaacc ggcgaccgcc gagctgctcc tcgccacgac ggggcacggg cggctcggcc
    13981 gccacctgct ccggccggcc aaccggtggg ggcccggctt ctacggttcg ctgctgccgt
    14041 acgcggccgg ggaccgccgc gtccttctcg gcgcggtcgc ccggcgggcc gtcccggcgg
    14101 atcccgccgc cgccgacggc ccgatcacga tggacctggt cgtggcggcc ggactcgggc
    14161 cctgggagcg gttcggggaa ctgctcctca ccgggcctgt gcggaccgac gaccgcgagc
    14221 cgctgcggtt cgaccccgtc cggcatccgg tcccggggct gcggcccgcc ggtgcgctcc
    14281 agcagatgcg gggacgcgcg tacgacgccg tccagcacgt ggacgagcac ccccgcgcgg
    14341 gccgggccgt gaccgggcgg aggggcgccg tcccgcgcag gcgcccgcgc gcacaccgcc
    14401 ggctccagcg gctctacgaa gggctgcggg agcgtccggt caacttcgcg cccggcgacc
    14461 ggccggagca cgcggggacc ggcggctggc acatggacga ccgccgccag gccctcccgc
    14521 cggagcgtcc cggaccgccg gagccggacg gcagctggga gatcgcgcgc cgcctcgtcc
    14581 gggactacga gttcgccgac ccgcggatca tccgcagcgc ctaccgtcgg agcgcccccg
    14641 cgcccggcgc cgacatgctg ctcgagggcc ggttcttcgg gctgcgcttc cccctcggcg
    14701 tccgcgtcgg cgacgtcgtc gacacgacca ccgagcagga cgggcggccg gtgcgggtgt
    14761 ggggctggaa ctaccggacg ctggaagggc acctggagcg cggccagatg gaccaggagg
    14821 tgcgcaaatg gctcgacacc ggggacgtgg agttccggct gcgcgccttc tcgcaccgcg
    14881 ccccgatccg caaccccgtc gtccgcctcg gcttcgagct gttcggccgc ccgacccagc
    14941 tcgtctacca gcgccgggcg tgccgccgca tggcgcacct gaccaggacg gaactcgccg
    15001 cccgcaggcc cgcgccggcg gagtgaggcg cggggcgcgt cagccggcga gggactcgcg
    15061 gacggtcatc agcgcgaagc ccagcaggtt cagcccctgc cattcggcgg gctcctgcgc
    15121 gcgcgggtcg tcggcggcca ggccgatgcc ccagacgcgg tcgagggggc tggcctccac
    15181 gagcacccgg tcgcgggtgc cggcgaggta gtcgcgcagc tccgggttct gctcgaactt
    15241 cgcccggttc ccggcgacga cgatctccgc gcggcgggcc gtccaggcgt cgtcgtcgaa
    15301 gccgcggacg cgccggccga ggtccttggc ggcgcccggg tggggcgcgt cgatgacggc
    15361 ggcggccgtt tccccgtcgc cgaacagccg ggccttctcc gccatcatgt aatgctccgc
    15421 agtggcatag gtcacgtcgc cgaccgtgaa aggcgacggc caccattggc tgagatagcc
    15481 gggccccggc ttgcggtgcc cccagaagaa caggtacttc gggcgggccc cctcctcgtg
    15541 gaggcggatg agctgctgga cgtccatgcc gacgatggtg gcagggcgag ggccgcgggg
    15601 cgaaccggtt tcgcccggcg gaataccgca ccggcggcgg agcgttatgc acggtgcagc
    15661 ccgcgaggtc tagaccattt tgctaaacca ggtgggtctt cgggcaagat ctccttattt
    15721 cggtcggccc ggatgccgag aatcgcgggc cgtcgtcaac gggaggacag cagtagaaat
    15781 ggacaacgcc ctggcgaacc ctcgtcgcac ccggatctcc tcgtggccgc agcggcccgc
    15841 ggacgccgac accgagcgtc ccctcgacgc ggagccgacc gcccccgagg acgacctcgc
    15901 cgcacgttga ccggccggac acggccgcga ccaggacccg cccgatgttc cgggcgggtc
    15961 ctggtctttt ctgcgcgtcc ttctccgcgg gtcagcgggg cggggcggtg ctctcgcgca
    16021 ggatgacgtg cccggcgacg cgctccagcc ggctgcgccg ggcggccggc tcgcgcagtg
    16081 cgaggcccat gacgtgctcg cccatcgcct ccagcgggag cgcgacggtg gtgagcggcg
    16141 gggtcaggtc gcgcacgatc gggatgtcgt cgaagcccgc gagcgacatc tcccccggca
    16201 ccgcgacgcc gtggtcgcgc aacgcggcga gcgcgccgat cgccatcacg tccgtcaccg
    16261 cgaacacgca ggtcggacgg ggcgtgcggc gcagcagctc ggtcgccgcg cggtacccgc
    16321 cgtcgcgcgt gaaggactcc tcgacgatgt gctcctccgg cacggcgatc ccggcgtcgg
    16381 cgagcgcctc ggtgaacccg ccgagccggt cggagacggt ggtgagcgcg cgcggcccgc
    16441 tgagcacgcc gaagtcgcgg tggccgaggt cgagcagcgc ccgggcgagc gcgccggcgc
    16501 cctcccggtt ctgcggcagg acggcgtcga ccttgaggct gcggtgccgg ctgaggaccg
    16561 cgacgcgccc gccggtgcgc tggtagggct ccagctcggc ggccatccgg cgctcccatt
    16621 cgcggtcctc gaagccggag ccgatgagca ggatcgcgcg ggcccgctgg gcgcgcagca
    16681 tcgccacgta ctcgatctcg cgggaggcgt cgcggaacgt gctggccagc atgacgagca
    16741 tgccgtgctc ggcggcggtg cgcatcacgc cgcgggcgac ggcggcgaag taggggtcgc
    16801 tgacgtcgtg gcagatcacc ccgacggcct tgctggagga gccggcgagc gcctgcgcgt
    16861 gcgcgttcgg ggtgtagccg agctcggcgg cggcggccag cacccgctcc cgcagatcgg
    16921 ctctgacctg cgacgtcccg ttcagcacgc gggacgcggt ggcgagcgag acctcggccc
    16981 gccgggcgac gtcctgcagc gtgacgtacg cccgctcccc ggtgcgcggc tcctccgccg
    17041 cctcggtcat gcgtcctcct cgcagggggc gcgtcccccg ctcccccggc cggggccgcg
    17101 gccgctccgc gccccctcgc cggccggtcc gcggcgggcc cgtttcgcgt gaccctcttg
    17161 accgcgcccg gcgcaggttc ttacggtacc tcagaaagcg ctttctgaac gcgctttctc
    17221 ggcacggtcc cggaggaacc atggtgagtc agcacctctc gcggggggac gatcccccgc
    17281 gctccccgaa ccggtccccg cgcggaccgg gcacggcggc cgcgacgccg gccgccgaca
    17341 cggccggggt cgtcgaacgc gcccggccga gcgccggcga gcggctcgcg ggcgcgctcg
    17401 agtcggcctg gcggccggtc gcgctgctcg tggcctgctt cgccgcctgg tgggcggtca
    17461 ccgcgttcaa gctggtcgag gcgtacctgg tgccctcgcc gtggacgacg ctgaagctga
    17521 tgggcgacaa gtggggctac atctggcacc acacgtgggt gaccacctac gagaccctga
    17581 tcggcttcgc gctcgccgtc gtcatcgggg tcgccgccgc ggtgctcatg gtgtactccg
    17641 gcacggtcga gcgcacgctc tacccgatcc tgctgttcgc gcaggtcatc cccaagatcg
    17701 cgatcgcccc gctgttcgtg gtctggctcg gcttcggcat cggccccaag atcgtcgtgg
    17761 cggtgctgat cgcgttcttc ccggtggtga tctcgatggt cgccgggctg aaggcggtcg
    17821 atccggagat gctccaactg tcgtccacga tgggcgcgag cgcgttcgcc accttcacca
    17881 agatccggct cccggcctcg ctgccgcacc tgttctccgg cctgaaggtc gccgtgacgc
    17941 tcgccgtcac cggcgccgtg gtcggcgagt tcgtcggcgc gaacgagggc ctcggctacg
    18001 tgatcctgca ggccaacggc aacatcgaca ccccgatgct gttcgccggg ctgctggtca
    18061 tgtccgccat cggcgtcgtg ctgttcgtcg ccgtggagat cgccgagaag ctcctgctcc
    18121 cctggcacgc cagccggcgc ggcgagtcgg tcaccacgac ctactgacac cgctcccttc
    18181 ccccaagaac ccgcctccac gaaccggccg cacggccggg agctcacccc acccatggag
    18241 gaccgttcca tgaaactccg catcctcgcc gtcaccgccc tcgtcccggc cgtcgcgctc
    18301 gcggccgccg cctgcggcgg ggactccggc gagaccaccg gcgcctcggg caagaagctc
    18361 aagaaggtca cgctcaccct gaactggtac ccctacggcg agcacgcgcc cttctactac
    18421 ggcaagaaga agggcatcta cgagaagcac ggcatcgacc tggagatcaa ggcgggccag
    18481 ggctcgcaga agaccgtcca ggccaccggc gccgggcaga ccgacttcgg ctgggccgac
    18541 accccggcgc tgctcgccgc cgtcgacaag ggcatgccga tcaagagcat cggggtgttc
    18601 ctgcagacca cgcccgcgtc ggtgcaggcg ttcagcagca agaacctgaa ggcgcccgcc
    18661 gacctgaagg gcaagaagat cgccatcacc gcgggcgacg cgctgtcgcg cacgttcccg
    18721 gtgttcctga agaagaacgg gctgtcggag ggcgacgtcc cgctgcagaa caccgacccg
    18781 gccgggaaga tcgccgcggt catctccggc aaggccgacg gcctcgtcgg gttcgccaac
    18841 gaccagggcc cgacggtcgc gaacaagtcc ggcaagccgg tgtcgtacct gcgctactcc
    18901 gacttcggcg tcaacttctt ctccaacggc ctgctcgccg gcgagcggaa gctgaagagc
    18961 gacgccggcc tggtcaagga catggtcgcc gccaccagcg aggcgtggag cgccgccgag
    19021 gccgacccgc agggcgcggt cgccagcatg gccggcgcgt ccgagcagct gccgccgacg
    19081 ccggtcgtcg ccgagcagtt caagaccacg ctgacgctgc tgcacaccca ggcgacgcag
    19141 ggcaaggcgc ccggcgtcaa caccgaggac gactggaagc agacgatcac gctgttccag
    19201 cagaccgggg tcatcggcaa ggccgaggcg ccctcgaagt actggtcgcc gcagctggcg
    19261 gcgcagggat gagcggacgg gcgatgaaga ccatgagcga accggggaag gccgcggccg
    19321 agcgggcgtc cgccgtgcgg atcgacgagg tggccgtccg gttccgcagc aagaagcgcg
    19381 aggtcaccgc gctgcgcgag gtgtcgctgg acgtcccgat gggagagttc gtcgcgatcg
    19441 tcgggccgtc cgggtgcggg aagtcgacca tgctgaagct ggtcgccggg ctgctcaagc
    19501 cgtcgaccgg gaccgtccgg ctgaacggcg agcaggtcgc cgggccgcgc gccgacatcg
    19561 gctacgtgtt ccagcgggcc gcgctgctgg agtggcgcag cgcccgcaag aacatcctgc
    19621 tccaggcgga gatgcgcaag atgcccgccg agcaggcgcg caagcgcacc gccgagctga
    19681 tcgagatgac cgggctgacc gggttcgagg acgcgctgcc gcacgagctg tccggcggca
    19741 tgcagcagcg ggtcgcgctg tgccgggcgc tgctgcacga gccgcccgtc ctgctgatgg
    19801 acgagccgtt cggcgcgctc gacgcgctca cccgcgagca gctcaacatc gagatgaacc
    19861 ggatctggcg ggagacgggg acgaccgtcc tgctcgtcac gcactcggtc gccgaggccg
    19921 cgtacctggc gaaccgggtc gtggtgatga ccgacaggcc cggctcgatc gccgaggtca
    19981 tcgacgtgga cctgcccccg gagcgggact acgcgcagac catggcgcag ccggagttcg
    20041 cccgcgtcac cggccggatc cgcacgctcc tcggcgccgg tgcgggcgcc ggcgccgcgc
    20101 tcgactagtc actccgcaca cgacgaaggc ttgggaagga acgggatggc acgcaagtcc
    20161 atcgggatcg tcatgaacgg cgtcaccggc cggatgggat accggcagca cctcctgcgc
    20221 tcgatcctcg cgatccgcga gcagggcggg ctgcggctcg cggacggcac cgacctgtgg
    20281 ccggagccgg tgctggtcgg ccggtcggag gcgaagctgc gcgacctcgc cgcgcggcac
    20341 gggctggacg cctggacgac cgacctggac gaggcgctgg cccgtccggg cgtcgaggtg
    20401 tacttcgacg cgcaggtcac cggcgcccgc gtcgcggcga tccgcaaggc ggtcgcggcc
    20461 ggcaagcacg tctacaccga gaagccgctg gccgacgacc tggagggcgc gctcgcgctg
    20521 gcgaagctcg ccgacgagtc gggcatcaag cacggcgtgg tgcaggacaa gctgttcctg
    20581 ccgggcctgc tgaagctgaa gcggctgatc gacggcgggt tcttcggccg gatcctgtcg
    20641 gtgcgcggcg agttcggcta ctgggtgttc gagggcgact ggcaggaggc gcagcggccg
    20701 tcctggaact accgggccga ggacggcggc gggatcatcc tcgacatgtt ctgccactgg
    20761 cggtacgtgc tggacgcgat cgcgcaggtc aggtcggtgc aggcgctcgg cgcgacgcac
    20821 gtccccgagc gggtggacga ggacggcaag ccgtacgagg cgaccgccga cgacgccgcg
    20881 tacgggatct tcgagctgga cggcgggatc gtcgcgcaga tcaactcgtc gtggacgacc
    20941 cgggtgttcc gcgacgagct ggtggagttc caggtcgacg ggacggaggg ctcggcggtc
    21001 gcggggctgc ggcgctgccg cgtccagcac cggtcgatga cgccgaagcc ggtgtggaac
    21061 ccggacctgc cggcgacgga ggacttccgc gcgcagtggc aggagatccc ggacaacacc
    21121 gtcttcgaca acggcttcaa gacgcagtgg gagatgttcc tgcggcacgt gaccgaggac
    21181 gcgccgttct cctgggactt ctacgcgggc gcgcgcgggg tgcagctcgc ggagctgggg
    21241 ctgcaggcgt ggcgcgaggg ccgccgcatc gaggtgccgg agctgcgccg atgaagatcg
    21301 agctgccgga gccggacggg acgctcgtcc cgtacacgat gggcgagccg cgcgcctacc
    21361 cgcggccgtc cgggccgccg tcgtcgcggg tcgcgtacgc ggcggcgcac gtggtcgccg
    21421 acccgttcgg cgactcgctg gactgggacg cgacgctggc gttccgccgc cacctgtggt
    21481 cgtacgggct gggcgtcgcg gaggcgatgg acacggcgca gcgcgggatg gggctggact
    21541 gggcgacgac ccgcgagctc atcgtgcgca gcagtgagga agcgctttca gtaggcggcc
    21601 ggatcgtctg cggagcgggc accgaccagc tcccggccgg tcccgcctcc ctggaggcga
    21661 tcacggcggc ctacgaggag cagctcggcg tcatcgaggg cgccggggcc gtcccggtgc
    21721 tgatggcgag ccgccatctc gccgccgccg cgcgcgggcc ggaggactac gcggcggtgt
    21781 acgggcggct gctgccgcaa ctgcgcagcc ccgccgtcct gcactggctc ggcccgatgt
    21841 tcgacccggc gctggagggc tactggggct cgtccggcct ggacgccgcc gccgacgcgg
    21901 tgctggcgct catcgccgag cacgccgcgt cgatcgacgg agtcaagatc tcgctgttgg
    21961 acgccgaccg ggagatcgcg ttccggcggc gcctgccggc gggcgtccgg ctctacaccg
    22021 gcgacgactt caactacccg gaactgatca agggcgacgc cgaggggcac agcgacgcgc
    22081 tgctcggcat cttcgacccg atcgccccgg cggccgccgc cgcgctgcag gccctcgacc
    22141 ag
//
