LOCUS       NZ_CP053892            26086 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3016601
            Orig. end                         :: 3042687
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..26086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    651..666
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.16"
                     /tool="antismash"
     misc_feature    complement(780..793)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.89"
                     /tool="antismash"
     misc_feature    complement(1236..1249)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.77"
                     /tool="antismash"
     misc_feature    complement(1243..1259)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.91"
                     /tool="antismash"
     gene            complement(1281..5300)
                     /locus_tag="ACTIVE_RS12545"
                     /old_locus_tag="ACTIVE_2513"
     CDS             complement(1281..5300)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="ACTIVE_RS12545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2513"
                     /product="WD40 repeat domain-containing protein"
                     /protein_id="WP_173095232.1"
                     /transl_table=11
                     /translation="MSAPQDGREPPAADEPGADDPASAPGGADLRAQAADHARVYQAGR
                     DQHFHYGTGTRGRRRATADAGECPYPGLAAFGAGQARWFFGRDRFIAELLGRLDRRLRT
                     GGIQMVVAPSGAGKSSLLHAGLLPRLSASALPGSERRPQLVLTPTADPLRALAARIVAL
                     NGADAGETAARLLAEPRSCAAMLRQALGEREDPEGGPGDGAVVVVDQFEELFTLCPDEA
                     HQRAFVNALADLAAAPEDGAADPVALVVVGLRADFYAACVDHPELRRALQDGQLLVGAM
                     DAGELREAIEYPAQDVGLELEPGLVELLLRDLGATADGASGADPGGADGPGYEAGRLPL
                     LAHALRASWRQRHGAVLTVEGYEATGGIQRAIATTADDVMAGLDDAGRDAARTVFLRLV
                     RIGDGADDTRRRLPRAALVDAAADPSAAAAVVDAFTAARLLTRDRDTVEITHDALLRSW
                     PRLRRWIDGDRAGRLVRQDLEEAADGWERRDRDTALLYRGSRLDAAREWAAKAAPGDVG
                     PVARAFLAASVRSRRRAARLRTGITAVLAVLVLVAVTTAVVALKQRDAADEQQRVAIAR
                     QLVAKADTALDTDPRTALRLDLAAHRLHPDAETYASLQQAITTTPYAGQLTGVSTDVTS
                     VAYSPDGRYLAAGFASGAVMLWDMRDPSRPRRVGAPFIGFDSSVMLAFAAGGRRLVTAS
                     PTGASAIWDLTDPARPRQVGAPRKGDQSSSGSAWLSADGTVLATSSKKNPRLQLWDLTD
                     PARIRPLGPALDAHPEQVLAVAFSAGGTMMATSGGRRGSEVKLWDVRRREAPRPLGRLT
                     PEPDDVVGSLSFSADGKELAVGGGLRGTALWNVGDPARARPARGLVQVASFASGATFSP
                     RGTTLAAIGNRDTGLQLWDTAEPDFPRRTERLSVGENDRVVAFSPDGRMVASGSVQGRV
                     TLWNLGRAGHPRAMGPLFHGHTGYYKETYSLAVSRDATMLATGGRDDTVALWEISDPAR
                     PRRLGTLTGHTGEGVNAVGFAPDGTVLATGDANGAVILWDLADRGRPRRLGPVLTGPTD
                     IVRSLVFTRDGATLLVGGDRATLVWDVRDHARPRLVAKVLGGEGVLGIWQVRGGRVLAL
                     VRGSGTAPAPAAVPQPTIPASGETGAHQNGPAGGPVSGPGDPKGARLWDITDPRRPRRE
                     GRALVGHDDEVGTAAMSPAGDLLVTGDRGGAAILWDVKDPAKARRLGDPLAPYGSTSQF
                     TMAFAPKADIMATGGIDGDVYLWDLGNRILPRRMGTALAGNVDAVFHVAFSADGKILAT
                     ADGDGGVVLWDLRPVYDLRRHLDATTCLVTGGGLDREQWARYLPTRRYENTCAGE"
     gene            complement(5341..5754)
                     /locus_tag="ACTIVE_RS12550"
                     /old_locus_tag="ACTIVE_2514"
     CDS             complement(5341..5754)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS12550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_2514"
                     /product="hypothetical protein"
                     /protein_id="WP_173095233.1"
                     /transl_table=11
                     /translation="MEPLVMAAGTALVTAIATDGWQQARAGAVALWRRVHPERVPAIEA
                     ELEEVRGEVLAARDAGDREAEDRLADEWRHRLARLVAADPAAAAEIRRVLDEVWSPLLP
                     EQERERVQNITMRAEASGHGRVYQAGRDQHITE"
     misc_feature    5824..5837
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.02"
                     /tool="antismash"
     misc_feature    complement(5825..5838)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.19"
                     /tool="antismash"
     misc_feature    complement(5919..5928)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 12.89"
                     /tool="antismash"
     gene            5976..7550
                     /locus_tag="ACTIVE_RS12555"
                     /old_locus_tag="ACTIVE_2515"
     CDS             5976..7550
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0009410 - response to xenobiotic stimulus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="ACTIVE_RS12555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2515"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_173095234.1"
                     /transl_table=11
                     /translation="MAKANAGRSPRRWWALAALTLSVLIVGLDGTIINVALPTLADDLG
                     ATSAQLQWIGGGYLLALSVGMLPAGLLGDRYGHRRLLVAGIALFGLASAVGALAGTAGQ
                     VIAARAVLGLGAAMITPLSMAILPKVFGKDELPRAIGVWTAATAVGMPIGPLLGGWLLD
                     RFPWGSVFLFNVPVTVLAAVACLRLLPADGPRVRDGRPFDYLGTVLGTLGIVALVYGTI
                     QVPGHGWGGPSVLAPLAAGAVLMVLFVRRQRRAAAPLVDLGLFADGTFRWGAIIAVFVN
                     FAVMGLLFVVPQYLQAVLGNGAFGGGLRLLPLIGGLMAAATLAEPLVPRLGARVVIPAG
                     LLLLAAGALLGAATGPGDGYAPAAGWLSLAGLGFGLAIVPATSMVLGTLPQDGTGTGTS
                     LLETIQQLGGALGVAALGSVLNAGYLARLSVTGLPDAAAGAARGSVTGADAVASQLHDK
                     ALAASAHGAFVHGMDLTLLVCAGAALVAAALAVAFLPRRAGAAQAERGAAAAEAPQPAV
                     RAGELPA"
     gene            7547..8161
                     /locus_tag="ACTIVE_RS12560"
                     /old_locus_tag="ACTIVE_2516"
     CDS             7547..8161
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037625.4"
                     /locus_tag="ACTIVE_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2516"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_173095235.1"
                     /transl_table=11
                     /translation="MSTRETPAAGKACGLRERKKAKTRLAIRRAAYRLFDEQGYEATTV
                     DQIAEAAEVSPSTFFRYFPAKEDVILSDEYDSALVDALAARPADEPVLLSLRHSMTDSL
                     GLVLEADREELFTRIRLSFTDPGIRARAMDEQLRNQEAVAAAIAERTGRDAAALDVRCA
                     AAAIIAVSMTVMRHWVDGGGTEDLTALYDRQLTTLFEGLRL"
     gene            complement(8180..9160)
                     /locus_tag="ACTIVE_RS12565"
                     /old_locus_tag="ACTIVE_2517"
     CDS             complement(8180..9160)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540277.1"
                     /locus_tag="ACTIVE_RS12565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2517"
                     /product="DUF2804 domain-containing protein"
                     /protein_id="WP_173095236.1"
                     /transl_table=11
                     /translation="MPTHEREITEPVDLCLPDGRLNPAAVGWTRRPLHRANLRGWGRTK
                     RWEYWGVVTPRHIVGLVASSLDYAGVHGLYVLDRETGEEIARDAVVPFARGAAFPERSG
                     EGEAAVRGGGAAVGVRQRPDGTSVRAAARGVRIELEIPLPAGHESLGVVIPWSDTRFQY
                     TVKDVGRPVHGRLVLPSGEHEVGEGAFAVLDHGRGKWPYRMTWNWAAAAGPGIALQLGG
                     KWTDGTGMTENALVVDGRLHKIGDELEWTYDRSGWTRPWAILGDRVEVEFRPFHEKVSR
                     VELGLVGSETHQCFGHFSGRARTDDGAWIEFDGLTGWAEEARQRW"
     misc_feature    9247..9262
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.76"
                     /tool="antismash"
     gene            complement(9248..9808)
                     /locus_tag="ACTIVE_RS12570"
                     /old_locus_tag="ACTIVE_2518"
     CDS             complement(9248..9808)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS12570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_2518"
                     /product="hypothetical protein"
                     /protein_id="WP_173095237.1"
                     /transl_table=11
                     /translation="MVGLMGVSAVLVAGCGGSGGTSHAATKSTGAKSTAPAAPAARKLT
                     FDLVKGVGETALGGDSACGYGEWNDGTFAIDKPYSKQTTFYREYSCYEKKGELFPNAAG
                     QMSYAEFGSPAQATAYGNYTKTNISAVAVLVSDNTAVTVNIGYLTLNKMTLLKQVQQSC
                     GGCGTVIAGPHASDPVPGHVDKS"
     gene            10001..10858
                     /gene="hpnC"
                     /locus_tag="ACTIVE_RS12575"
                     /old_locus_tag="ACTIVE_2519"
     CDS             10001..10858
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634148.1"
                     /locus_tag="ACTIVE_RS12575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2519"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_246342803.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.4e-40, bitscore:
                     138.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.3e-42,
                     bitscore: 143.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITDSPWSAFDHDRMLDALAARENFPVAARLLPARHRADLRAVYG
                     FARLVDDIGDEAPREQRADLLALVDDDLDLVFKGGTPKLPQLRRLAGTVHAHAIPAEPF
                     RRLVEANRQDQVVHRYETFEQLVEYCALSADPVGRIVLHVFGAQGAGLESASDRVCTAL
                     QIIEHCQDVAEDHRDGRVYLPAEDLRRFGCEDADLSRRVTPTRLRGVLALEAGRARDLL
                     DRGAAPLMKGLSGWARVAVGGYVAGGRATLAALAGARYDVLAHPPRPRRAAVLAGWARA
                     LGRG"
     misc_feature    complement(10861..10872)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.92"
                     /tool="antismash"
     gene            10862..11779
                     /gene="hpnD"
                     /locus_tag="ACTIVE_RS12580"
                     /old_locus_tag="ACTIVE_2520"
     CDS             10862..11779
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634147.1"
                     /locus_tag="ACTIVE_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2520"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_173095238.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.7e-56, bitscore:
                     189.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 5.5e-67,
                     bitscore: 225.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSETCERTDEIAGAYRHCERVVREEARNFSYGIRLMPPPKRRA
                     MSAIYAFARGVDDIGDGPEPACVRLDLLDRSRQRLVTVQEVLRRRSDVRALEGHPVLTA
                     LADAAGRFPIPLAAFDELIDGCESDVRGARYETFDDLLRYCQQVAGTVGRLSLGVFGSD
                     GRQRAEGLADSLGVALQLTNILRDVREDRMAGRVYLPAEDLEQFGCTLELDESGVFIDP
                     PWRLHKLIGFQAERARAWYAEGLRLLPLLDRRSAACTAAMAGIYRRLLESIAANPAAAL
                     NSRVSLPTWQKAVVAARALTGVER"
     gene            11776..13095
                     /gene="hpnE"
                     /locus_tag="ACTIVE_RS12585"
                     /old_locus_tag="ACTIVE_2521"
     CDS             11776..13095
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634146.1"
                     /locus_tag="ACTIVE_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2521"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_173095239.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.1e-06, bitscore:
                     26.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 2.5e-11, bitscore: 42.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVVVVGGGLAGISTAIALQETGVPVTLVEARPWLGGATHSFRRD
                     ELSVDNGQHVYLRCCTAYQGLLRRLRAEHLVRMQDRFDVAVLRPGARPARLRRSPLPSP
                     LHMLPSLARYSHLPVSDRLRAVLASAGLQRLDPDDPALDLRSAGAWLAEHGQRPWAREA
                     LWGLFITAALNAEVDDAALGLSAMVCRRALFGRPDAADIGVPTVPLAELHGGPALRRIA
                     EMGGTVRLKAKVEAVTTDPKVIVDGVPIAADAVVLAVPHEAAARLLPAEALPQPLRWHE
                     LDASPIVNVHVVYDRPVLDEPFAAAVGSPVQWIFDRSGVAGLRDGQYLAISLSAADRWI
                     DRPTAALRAEFVPELARLLPGARGARVRELFVTRERRATFRQRPGSRSPRPGAATRARG
                     LFLAGAWTDTGWPDTMEGAVRSGLTAARLVRRHLEGVRDR"
     misc_feature    complement(13131..13145)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            13148..14170
                     /locus_tag="ACTIVE_RS12590"
                     /old_locus_tag="ACTIVE_2522"
     CDS             13148..14170
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634145.1"
                     /locus_tag="ACTIVE_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2522"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_173095240.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.2e-61, bitscore:
                     207.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVPVSMTDVRGLVDGALRAAVGRLDPRTYRVAAYHLGWADEEG
                     RPLAAPAGKALRPALALLSARAAGAPPESALPGAVAVELTHAFSLLHDDIMDGDRTRRH
                     RPAAWTVFGEPAAILAGDALLALALEVLLEAPGQGSARAARALAVATRRLISGQSLDLE
                     FETRRQVGLEECAAMAADKTAALLACSCAIGAVLDGAPEPLCAALEAFGADMGLAFQLV
                     DDLLGIWGDPATTGKPALSDLRSRKMSLPVVAALTSGTPEGARLAELYARPPDPDGPGE
                     DDLAEAAALVDAAGGRAWAEAEADKRIASATAHLASAALPEPVRAEFLHIAAFVTRRDH
                     "
     gene            14170..16086
                     /gene="shc"
                     /locus_tag="ACTIVE_RS12595"
                     /old_locus_tag="ACTIVE_2523"
     CDS             14170..16086
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540957.1"
                     /locus_tag="ACTIVE_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2523"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_173095241.1"
                     /sec_met_domain="T2TS (E-value: 5.3e-152, bitscore: 506.2,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATEPTETTGTATAGTAESTAVRTPAEAMAAARDHLLGLQSPEG
                     WWKGELQTNVTMDAEDLLMREFLGIRTAEDTREAARWIRSQQAPDGTWANFHDGPPDLS
                     TTVEAYVALRLAGDEPDAPHMRRAAAFVRGEGGIPATRVFTRFWLAMFGQWPWERLPAL
                     PPEMVFLPHWFPLNVYDFACWARQTIVPLTVVAAKRPVRPLPFELEELRSGRVVRRRRG
                     AVPGWDEAFAALDRVLRGYERRPLRGLRKAALRRAAEWIIARQEPDGSWGGIQPPWVYS
                     LLALHLLGHGLDHPVVRRGLEGLERFTVRDEKGRRLEACQSPVWDTVLAMNALVDAGLP
                     AGHQALEAAAEWVVGEEVQGPGDWSVRRPDLPPGGWAFEFDNDYYPDTDDTAEVVLALS
                     RVDHPKAEPAIERGVRWMAGMVSRDGGFGAFDADNTRALCRRLPFCDFGEVIDPPSADV
                     TAHVVEALSLRGMADSTLVKRAVVWLLKAQEDDGSWFGRWGANHVYGTGSVVPALIAAG
                     VRPEKPAIRRAVRWLERHQRDDGGWGEDLRSYRDPEWVGHGVSTASQTAWALLALLAAG
                     ERGPAVERGVRWLVEHQRPDGTWDEDHFTGTGFPGDFYINYHLYRLVFPLSALGRYVKE
                     IGS"
     gene            16087..17091
                     /gene="hpnH"
                     /locus_tag="ACTIVE_RS12600"
                     /old_locus_tag="ACTIVE_2524"
     CDS             16087..17091
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634142.1"
                     /locus_tag="ACTIVE_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2524"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_173095242.1"
                     /sec_met_domain="PF04055 (E-value: 1.1e-17, bitscore: 64.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 2.7e-08, bitscore: 32.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSLRVGGYVLRNKLAGRKKFPLIVELEPLFACNLACAGC
                     GKIQHPASVLKQRMPVEQAVAAIRECGAPMVSIAGGEPLMHPQIGELVRELIRMKRYVF
                     LCTNAALIPRKIDDFEPSRYFAWAVHIDGLRERHDASVCKEGVFDEAVAAIRMCQERGF
                     RVTTNTTVFNTDTPQTVIDVLNYLNDDLRVDQMMISPAYAYEKAPDQDHFLGVQETRSL
                     FQKAFADGNRKRWRFNHSPLFLDFLEGKADFPCTAWAIPSYSLKGWQRPCYLMEDGYAE
                     SYKELLEETDWDAYGRGRDDRCANCMAHCGYEPTAVFATMGSLKESLRAVRSV"
     gene            complement(17092..19098)
                     /locus_tag="ACTIVE_RS12605"
                     /old_locus_tag="ACTIVE_2525"
     CDS             complement(17092..19098)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025736.4"
                     /locus_tag="ACTIVE_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2525"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_173095243.1"
                     /sec_met_domain="Condensation (E-value: 0.00012, bitscore:
                     20.3, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTQDAVTARDAVLTRDGAGTRGRASGEVLLGLALFGLYSLVAML
                     PEQVREHAARRRGEMVLGLERALHLDLEPALNGWLAARPVWRVLADYEYATTYVAATLA
                     VLVWLYVRHPERYRTARNAFVTLNVAAIACFALFPVMPPRFLGDLGFVDTVRLGRTWGS
                     WGSPLIEHADRFAAVPSLHMAWTLWAGVELARARAPRPVRALNGAHIAVTAYVIVATAN
                     HYVLDAVAAVPLVALSVLTAGRLAARPAAAERVPAQDAFFLAVESAAAPQHAGGVIMLD
                     TSRRALGRLDLVRLIGDRLDRLPRFRQRLADRGRWRRPVWLDHPAVDWSWHVTERTVDG
                     MAGLRAMIAEIQAEPLPRDRPLWRMILVAGAAPGRTTLVFLMHHVVADGVGVVAQAISL
                     MEPAAPGRPGGRGPAAPPRRRVREALAGAVGLAQLAADGGAGAAPRLPSAGTAGRRFGT
                     LRIPLAEPREIARRYGARVSDVVMCAVAGALQRTVRFPAGTPPRECRVAVPLMMRAPGE
                     GMEGNHTTAVMVDLPIGAMPERERLALIARRSRVLRSGTRALAAWFVMRQVGRLMPGPL
                     HARFARAVYGGRFLQGIVSSLPASGERMLLTGVPVTGVYPVVPLAPGAPLAVAALGVDG
                     ELCFGICADTGLVDDADALTAGVRDVIRELRDG"
     gene            19307..20062
                     /locus_tag="ACTIVE_RS12610"
                     /old_locus_tag="ACTIVE_2526"
     CDS             19307..20062
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631347.1"
                     /locus_tag="ACTIVE_RS12610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2526"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_173095244.1"
                     /transl_table=11
                     /translation="MGAAHRHGGPDLGWAFAAAALGAKAAHAAARHHGHGHGAGLRGDF
                     PGFGPMFGGGPGGPWGPPGGFGPGRAPWARGRGPWGRGPKARKGNVRAAVLVLLAEEPR
                     NGYQIIQEINERSGGAWKPSPGAVYPALQQLADEGLIAGEEGGGRRTFHLTDEGRTYVE
                     ENAERLAEPWAEMTPEFGEGVPELFKQAAQTGAAVMQIVHSGSPDQVAQARDVLSEARR
                     NLYRILADDAPAGASDGDDAGPTADDDEE"
     gene            20067..20576
                     /locus_tag="ACTIVE_RS12615"
                     /old_locus_tag="ACTIVE_2527"
     CDS             20067..20576
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019656.4"
                     /locus_tag="ACTIVE_RS12615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2527"
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_173095245.1"
                     /transl_table=11
                     /translation="MTRPDDIRIGDAERDAVMVALHDHFAAGRLDRGELDERLDAVLSA
                     KTRGDLRTLVRDLPAPTGLPEPGGPAAAFGNVPWGAGHAVMFGGPGHPMHHRHHRHRHL
                     AHHRRHGPHFAFPLMLAVFLVVTFTVGVGTAALAVLHIALAIWLVRAVMLLTGARRSRR
                     HLTPGA"
     gene            complement(20652..21590)
                     /locus_tag="ACTIVE_RS12620"
                     /old_locus_tag="ACTIVE_2528"
     CDS             complement(20652..21590)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564011.1"
                     /locus_tag="ACTIVE_RS12620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2528"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_216858390.1"
                     /transl_table=11
                     /translation="MIDLRRLHMLRLVHQYGTVTAAADALHLTPSAVSHHLRELARELK
                     VPLLEPQGRRVRLTPAAHLLIEHADAMLARWEEALADLESHRAGAHGPLRMCGFTTAVG
                     GLVAPAAGALLRADPALAIEIRECDTDVAVGLLAAGETDVAVIEPTADAPPPGDPRFDR
                     EPLMAEALDLIVPAGHPFAGRRDVRLEDAAAEAWISVQPAGCAHHQQVMAYCAAAGFTP
                     RIAHNATTWSVIWALVGNGLGVSLVPRLADGPADQPVVRVPLSGDAVPMRQVLTCVRRG
                     SRANPLIARALGALRDAVPSRCALPPERPAA"
     gene            21664..21843
                     /locus_tag="ACTIVE_RS12625"
     CDS             21664..21843
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS12625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_173091492.1"
                     /transl_table=11
                     /translation="MTQRDRVLSRHLTSDGVVVWSRCSCGRLRMDLVPAAGGPRLGAGP
                     CPHRDGGHTSSVSS"
     gene            complement(21819..22214)
                     /locus_tag="ACTIVE_RS12630"
                     /old_locus_tag="ACTIVE_2529"
     CDS             complement(21819..22214)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621667.1"
                     /locus_tag="ACTIVE_RS12630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2529"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_173095246.1"
                     /transl_table=11
                     /translation="MDATNIRETLDGLARQRTVLLTTYRKDGTPVGTPVNVVVRGDHAY
                     FRTYDKAYKTKRMARNPEVEIAPSTYSGKVTGPAVHGRVRLLGEDEAKPIRRMLARKHR
                     FQQGFAVPLLHRVKRYRTLHYELTLDV"
     gene            complement(22277..22903)
                     /gene="eda"
                     /locus_tag="ACTIVE_RS12635"
                     /old_locus_tag="ACTIVE_2530"
     CDS             complement(22277..22903)
                     /EC_number="4.1.2.14"
                     /EC_number="4.1.3.16"
                     /GO_function="GO:0008675 -
                     2-dehydro-3-deoxy-phosphogluconate aldolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008700 - 4-hydroxy-2-oxoglutarate
                     aldolase activity [Evidence IEA]"
                     /GO_process="GO:0009084 - glutamine family amino acid
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009255 - Entner-Doudoroff pathway through
                     6-phosphogluconate [Evidence IEA]"
                     /codon_start=1
                     /gene="eda"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619057.1"
                     /locus_tag="ACTIVE_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2530"
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="WP_173095247.1"
                     /transl_table=11
                     /translation="MNTEELLGLAPVVPVVVLDDAAHAVPLARALVAGGLPAIEVTLRT
                     PAAAESIERIAAEVPDAVVGAGTVVTADDAERSLKAGARFLVSPGCTPRLRAAMAGTGL
                     PFLPGVSSASEAMALLEEGITAMKFFPAEPAGGVPYLKALGGPLPRITFCPTGGIRPGN
                     AADYLALPNVGCVGGTWLTPSDAVAAGDWDRIRALAAEAAALRPS"
     gene            complement(22900..23883)
                     /gene="glk"
                     /locus_tag="ACTIVE_RS12640"
                     /old_locus_tag="ACTIVE_2531"
     CDS             complement(22900..23883)
                     /EC_number="2.7.1.2"
                     /GO_function="GO:0004340 - glucokinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631344.1"
                     /locus_tag="ACTIVE_RS12640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2531"
                     /product="glucokinase"
                     /protein_id="WP_173095248.1"
                     /transl_table=11
                     /translation="MTGTWLVADVGGTNARFALVDGPDGAPYRVGSLPTRDHAGLAEAA
                     AAYLDRYAPDVRPTAACLAVAGPVTGGGYHLTNAGWPKGTRQQVREHLGVPHLEILNDF
                     EALALALPRLGPDDVIPIGPAARTAEAAPLAVVGPGTGLGVAGLVPTAAGWVPLPGEGG
                     QVDVPAATDRELAVARLLRAEHGAARAESLLSGTGLARIHRYLAMLDGVQAEPLDPARI
                     CAHGDDPLCAEAVGMFCALLGSLAGNVALTLGARGGVHLGGGILPRIADELRRSDFRAR
                     FEAKPPVEDYMRAIPTSLIVHPNPALLGAAVRLAQTPAALETLETA"
     gene            complement(23880..25697)
                     /gene="edd"
                     /locus_tag="ACTIVE_RS12645"
                     /old_locus_tag="ACTIVE_2532"
     CDS             complement(23880..25697)
                     /EC_number="4.2.1.12"
                     /GO_function="GO:0004456 - phosphogluconate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009255 - Entner-Doudoroff pathway through
                     6-phosphogluconate [Evidence IEA]"
                     /codon_start=1
                     /gene="edd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020380046.1"
                     /locus_tag="ACTIVE_RS12645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_2532"
                     /product="phosphogluconate dehydratase"
                     /protein_id="WP_173095249.1"
                     /transl_table=11
                     /translation="MALHPVLERVTQRIAERSAARRTAYLDRIGAARTQGPARGGMGCA
                     NLAHGFAACGVQDKLWLRGNVTPNIAIVSAYNDMLSAHQPLKDYPDILKAAIRRAGGTA
                     QFAGGVPAMCDGITQGRAGMELSLFSRDVVAMATAVALSHDMFDGALLLGVCDKIVPGL
                     VIGALAFGHLPVILVPAGPMASGLPNARKAKVRKRYAAGEIGRDELLAAESASYHSPGT
                     CTFYGTANSNQLLMEVMGLHLPGASFVPPGTPLRDGLTEAAGRRVLKLTDLADEYTPIG
                     ELLDERAFANAVVALLATGGSTNHTLHLVAMAAAAGIELTWDDFDELSKVTPLLTRLYP
                     NGTADVNHFHAAGGTAFLIGELIDAGLLHEDARTVGGATLAAYRRVPRMDGGRVVWEDA
                     PAESGDTDVLRPAGEPFDTHGGLHTVNGNLGRAVVKVSAVSPEHRMIEAPARVFESQEA
                     LQEAFAAGELDRDVVAVVRHQGPRANGMPELHRLTPPLSVLQDRGFRVALVTDGRMSGA
                     SGAVPAAIHVSPEAAAGGPLARVRDGDVVRLDADKGLLEVLVPDEEFDARIPSAAAPSA
                     GESTGTGRELFEVFRRSVGAAELGAGVFA"
ORIGIN
        1 ggtccagcca caggccctgc tccttggcgt aggcctcgac gagcgcgatc tgctcgtcgt
       61 cccggccggt cagccgcagg tacttcagcg tctcgtcgtc gatcgggaag atcgcgcagg
      121 tggagccgaa ctcggggctc atgttgccga tggtggcgcg gttggccagc ggcagcgcgt
      181 gcacgccctc gccgtagaac tcgacgaact tgccgacgac gccgtgctcg cgcagcatct
      241 cggtgatggt gagcaccagg tccgtcgcgg tggtgccggc gggcagctca ccggtcagct
      301 tgaagccgac cacgcgcggg atcagcatgg agatcggctg gccgagcatc gcggcctccg
      361 cctcgatgcc gccgacgccc cagcccagca caccgatgcc gttctccatc gtggtgtgcg
      421 agtcggtgcc gacgcaggtg tcggggtagg cgacgccgtt gcggtcgaac accacgcgcg
      481 ccaggtgctc gatgttcacc tggtggacga tgcccgtgcc cggcgggacg accttgaact
      541 cgtcgaacgc cgtctggccc cagcgcagga actggtagcg ctccttgttg cgctcgtact
      601 cgacctgcac gttgcgctcg aacgcctgcg gcgagccgaa gtactcgacg atgacggagt
      661 ggtcgatgac catctcggcc ggcgccagcg ggttgatctt cgtcgggtcg ccgcccaggt
      721 cccgcacggc ctcgcgcatc gtcgccaggt ccaccacgca cggcacgccg gtgaagtcct
      781 gcatgatcac acgggccggg gtgaactgga tctccttgct gggccgggcc ttggcgtccc
      841 actgggccag cgcgcggatg tgctcggcgg tgacgttcgc gccgtcctcg gtgcgcagca
      901 ggttctccag cagcaccttc aggctgtacg ggagacgggc cgagccctcg acggcgtcca
      961 gccggtagat gtcgtacgac ttgccgccca cctgcagctt gctcaggctg ccgaagctgt
     1021 tcgcggacac ggactcctcc tccgtcgcac gccgcgcgtc cggtccggga catgaccgcg
     1081 cggcgacgtt catcgtgatg ttcaatgtgc gcccgccctc gcggccggcg cgggtcgggc
     1141 ggcgcggcgc gcggcgaggc gggtgtgctc gtctaccttg atcctgccct agtcaagccc
     1201 ttgaccgaga accgggtccg cctaacttcc gcaggttttt tcttgatgtc aagatacatc
     1261 caatttatct cgacatcaag ctactctccc gcgcaggtgt tctcgtagcg gcgcgtcggc
     1321 aggtaccggg cccattgctc ccggtccagg ccgccgcccg tcaccaggca ggtcgtcgcg
     1381 tcgaggtggc ggcgcagatc gtagacgggc ctcaggtccc acaggacgac gccgccgtcg
     1441 ccgtccgcgg tcgcgaggat cttcccgtcg gcggagaacg ccacatggaa cacggcgtcc
     1501 acgttgccgg ccagcgccgt gcccatccgc cggggcagga tccggttgcc gaggtcccag
     1561 aggtagacgt cgccgtcgat ccccccggtc gccatgatgt ccgccttcgg cgcgaaggcc
     1621 atcgtgaact ggctggtgct gccgtagggg gcgagagggt cgcccaggcg ccgggccttc
     1681 gcggggtcct tgacgtccca gaggatcgcg gcgccaccgc gatcgccggt cacgagcaga
     1741 tcccccgccg gcgacatggc cgccgtgccg acctcgtcgt cgtggccgac gagcgcccgt
     1801 ccctcgcggc gcggacggcg cgggtcggtg atgtcccaca accgggcgcc cttcggatct
     1861 cccggtcccg agaccggccc gcccgccggc ccgttctggt gcgcgcccgt ttcgccggac
     1921 gccgggatcg tgggctgggg cacggcggca ggggccggag cggtcccgga tccgcggacg
     1981 agggccagca cgcggccgcc gcgcacctgc cagatcccca gcacgccctc gccgccgagc
     2041 accttcgcga cgagccgggg gcgcgcgtgg tcccggacgt cccagacgag cgtggcgcgg
     2101 tcaccgccca cgaggagggt ggcgccgtca cgggtgaaca ccagcgaccg gacgatgtcg
     2161 gtgggaccgg tgagcacggg ccccagcctc cggggacggc cgcggtcggc caggtcccag
     2221 aggatcaccg cgccgttggc gtcgccggtc gcgaggaccg tgccgtcggg cgcgaagccg
     2281 accgcgttga cgccctcccc ggtgtgcccc gtgagcgtgc cgagccggcg cggccgcgcg
     2341 ggatcggaga tctcccacag cgcgacggtg tcgtcccggc cgccggtcgc gagcatcgtc
     2401 gcgtcccggg acacggccag cgaataggtc tccttgtagt agccggtatg cccgtggaac
     2461 agagggccca tggcgcgcgg gtggccggcc cggcccaggt tccacagcgt gacacgcccc
     2521 tgcacgcttc cgctggcgac catccggccg tccggtgaga acgccaccac gcggtcgttc
     2581 tcaccgacgc tcagccgctc ggtccggcgc gggaagtccg gctcggcggt gtcccacagc
     2641 tgcagtcccg tgtcgcggtt gccgatggcc gccagcgtgg tgccgcgcgg cgagaacgtc
     2701 gcccccgacg cgaaggaggc gacctggacg aggccgcggg cgggacgcgc cctggccgga
     2761 tctcccacgt tccacagggc ggtgccgcgc agccccccgc ccaccgcgag ctccttgccg
     2821 tcggccgaga acgagaggct gcccacgacg tcgtcgggct cgggcgtgag gcgcccgagc
     2881 ggccgaggcg cctcgcgccg ccggacgtcc cacagcttca cctcggaccc gcgcctgcct
     2941 ccggacgtgg ccatcatggt gccgccggcg gagaacgcca cggccagcac ctgctcgggg
     3001 tgggcgtcga gcgcggggcc gagcgggcgg atccgcgcgg ggtcggtcag gtcccacagc
     3061 tggagccggg ggttcttctt gctggaggtg gcgaggacgg tgccgtccgc cgacagccac
     3121 gcgctcccac tggaactctg gtcgcccttc ctcggcgcgc ccacctgccg gggacgggcc
     3181 ggatcggtca gatcccagat ggcggaggcg ccggtggggc tcgcggtgac cagccggcgg
     3241 ccccctgccg cgaaggccag catgaccgag gaatcgaaac cgatgaaggg tgcgccgacg
     3301 cgacggggac gcgacgggtc gcgcatgtcc cacagcatca ccgcgccgga cgcgaacccg
     3361 gcggccaggt accggccgtc gggcgagtag gcgaccgagg tgacgtcggt gctcacgccg
     3421 gtcagctgcc cggcgtaggg cgtggtcgtg atcgcctgct ggagcgaggc gtacgtctcg
     3481 gcgtcgggat ggagccggtg cgcggcgagg tcgagccgca gtgccgtccg gggatcggtg
     3541 tcgagcgccg tgtcggcctt cgccacgagc tgccgggcga tggcgacgcg ctgctgctcg
     3601 tccgccgcgt cccgctgctt gagggcgacg accgcggtgg tcacggccac cagcaccagg
     3661 acggccagca cggcggtgat cccggtgcgc agccgcgcgg cgcggcgccg cgaccggacg
     3721 gacgcggcca ggaaggcacg cgccaccgga ccgacatcgc cgggcgccgc cttcgcggcc
     3781 cactcgcggg cggcgtccag gcggctgccc cggtacagca gcgcggtgtc gcggtcccgg
     3841 cgctcccagc cgtcggcggc ctcctcgagg tcctggcgga cgagccggcc cgcccggtcg
     3901 ccgtcgatcc acctgcgcag ccggggccag ctgcgcagca gggcgtcgtg ggtgatctcg
     3961 acggtgtcgc ggtcccgggt gagcagccgg gcggcggtga aggcgtcgac caccgcggcg
     4021 gccgcggacg ggtcggcggc ggcgtccacc agcgcggcgc gcggcagccg ccggcgggta
     4081 tcgtccgccc cgtccccgat cctgaccagg cgcaggaaca ccgtccgggc cgcgtcgcgc
     4141 ccagcgtcgt ccagcccggc catgacgtcg tcggcggtgg tggcgatggc gcgctggatg
     4201 ccgccggtcg cctcgtaccc ctcgacggtc aggacggcgc cgtgccgctg ccgccagctc
     4261 gcgcgcagcg cgtgggccag cagcggcagg cggcccgcct cgtacccggg cccgtccgcg
     4321 ccgccggggt ccgcgccgct cgcgccgtcc gcggtggcgc cgaggtcgcg gagcagcagc
     4381 tcgaccaggc ccggttccag ctccaggccg acgtcctggg cggggtactc gatcgcctcg
     4441 cgcagctccc ccgcgtccat cgccccgacc agcaactgcc cgtcctgcag ggcccggcgc
     4501 agctccgggt ggtcgacgca cgcggcgtag aagtcggcgc gcagcccgac gacgaccaag
     4561 gcgaccggat cggccgcgcc gtcctcgggg gccgccgcca gatcggccag cgcgttgacg
     4621 aacgcgcgct ggtgcgcctc gtcggggcac agggtgaaca gttcctcgaa ctggtccacc
     4681 accacgaccg ccccatcgcc cggaccgcct tcggggtcct cccgctcgcc gagcgcctgg
     4741 cgcagcatcg cggcgcaact ccgcggctcc gccagcagcc gcgcggccgt ctcgccggcg
     4801 tccgcgccgt tgagcgcgac gatccgggcg gccagggccc gcagcgggtc ggcggtgggg
     4861 gtgagcacca gttgcggccg gcgttccgag ccggggagcg cggaggcgct cagccggggc
     4921 agcaggccgg cgtgcagcag cgacgacttg cccgcgcccg agggggccac gaccatctgg
     4981 atcccgccgg tgcgcagccg ccggtccaga cgcccgagca gctcggcgat gaaccggtcg
     5041 cggccgaaga accagcgggc ctggcccgcg ccgaacgcgg ccaggcccgg gtaggggcac
     5101 tcgcccgcgt ccgccgtggc gcggcggcgc ccgcgcgtcc cggtgccgta gtggaagtgc
     5161 tggtcgcggc ccgcctggta gacgcgcgca tggtccgcgg cctgcgcgcg aaggtccgcg
     5221 ccaccaggcg cggacgcggg atcgtccgcg ccgggctcat ccgcggcggg cggctcgcgg
     5281 ccgtcttgcg gagcactcat cgaccacccc tcacggcgcg ccggcacccg ggccctgcgc
     5341 ctattcggtg atgtgctggt cccggcccgc ctggtacacc cgcccgtggc cgctcgcttc
     5401 ggcgcgcatc gtgatgttct ggacgcgctc ccgctcctgc tccgggagca gggggctcca
     5461 cacctcgtcg agcacccgcc ggatctcggc ggcggcggcc gggtcggcgg cgacgaggcg
     5521 ggccagccgg tgccgccact cgtccgcgag ccggtcctcg gcctcccggt caccggcgtc
     5581 ccgtgcggcg agcacctcgc cgcgcacctc ttccagctcc gcctcgatcg cgggcacccg
     5641 ctcgggatgc acccgccgcc acagggccac cgcgccggcc cgggcctgct gccagccgtc
     5701 ggtggcgatc gccgtcacca acgccgtccc cgctgccatc accaagggtt ccatcaggac
     5761 atccccgccg tcagaggccg ccggcccgtt cgccgccacc accatcctga accaccccgc
     5821 aagatcacgc accgtgatgg gcgcggctcg ctccggcggg cctgaccgga aacggacagc
     5881 gccccggccg tcccacccac cgaaccgatt gacgaccctc aaatgacagt gaactatcac
     5941 ttatgagttc actgtcacat tctgggaggc gggtcatggc gaaggcgaac gcgggacggt
     6001 cgccgcggcg ctggtgggcg ctggcggcgc tcacgctgag cgtgctgatc gtgggactgg
     6061 acgggacgat catcaacgtc gcgctgccca cgctggcgga cgacctgggc gcgaccagcg
     6121 cgcagctgca gtggatcggc ggcggctacc tgctggcgct gtcggtgggg atgctcccgg
     6181 cggggctgct cggcgaccgg tacggccacc ggcggctgct ggtggccggg atcgcgctgt
     6241 tcgggctggc gtccgcggtg ggcgcgctgg cggggacggc cgggcaggtg atcgccgcgc
     6301 gcgcggtcct cgggctcggc gcggcgatga tcaccccgct gtcgatggcg atcctgccga
     6361 aggtgttcgg caaggacgag ctgccgcgcg ccatcggcgt gtggacggcg gcgacggcgg
     6421 tcgggatgcc gatcggcccg ctcctcggcg gctggctgct cgaccgcttc ccctgggggt
     6481 cggtgttcct gttcaacgtg ccggtgacgg tgctcgccgc ggtcgcgtgc ctgcggctgc
     6541 tcccggcgga cggcccgcgc gtccgggacg gcaggccgtt cgactacctc ggcacggtgc
     6601 tcggcaccct cggcatcgtc gcgctcgtct acgggaccat ccaggtgccc gggcacggct
     6661 ggggcggccc gtccgtgctg gcgccgctcg ccgccggcgc ggtgctgatg gtgctgttcg
     6721 tgcggcggca gcggcgggcg gcggcgccgc tggtcgacct cggcctgttc gcggacggga
     6781 cgttccggtg gggcgcgatc atcgccgtct tcgtcaactt cgcggtgatg ggactgctgt
     6841 tcgtcgtccc gcagtacctg caggcggtgc tggggaacgg cgcgttcggc ggcgggctgc
     6901 ggctgctgcc gctgatcggc gggctgatgg cggcggcgac gctggccgag ccgctcgtcc
     6961 cgcggctcgg cgcccgcgtc gtgatccccg cggggctgct cctgctggcc gccggcgcgc
     7021 tgctcggcgc cgcgaccggc cccggcgacg gctacgcccc ggccgccggg tggctctcgc
     7081 tggcgggtct cgggttcggg ctggcgatcg tcccggcgac gagcatggtg ctcgggacgc
     7141 tgccgcagga cggcaccggc acggggacga gcctgctgga gacgatccag cagctcggcg
     7201 gggcgctcgg cgtcgcggcg ctcggcagcg tcctgaacgc gggctacctg gcgcggctgt
     7261 cggtgacggg gctcccggac gcggcggcgg gcgcggcgcg cggctcggtg accggcgcgg
     7321 acgcggtggc ctcgcagctg cacgacaagg cgctggcggc gtccgcgcac ggcgcgttcg
     7381 tccacgggat ggacctgacg ctcctggtct gcgcgggggc cgcgctcgtc gccgccgccc
     7441 tcgcggtcgc cttcctgccc cgccgcgccg gcgccgcgca ggcagagcga ggcgcggccg
     7501 cggccgaggc accgcagccg gccgtgcgcg cgggagaatt gccggcatga gcaccaggga
     7561 gaccccggcc gccggcaagg cgtgcgggct gcgcgagcgc aagaaggcga agacccggct
     7621 ggcgatccgg cgcgcggcgt accggctgtt cgacgagcag ggctacgagg cgacgaccgt
     7681 cgaccagatc gccgaggcgg ccgaggtctc ccccagcacg ttcttccgct acttcccggc
     7741 gaaggaggac gtgatcctgt ccgacgagta cgactcggcg ctcgtcgacg cgctcgccgc
     7801 gcgcccggcg gacgagccgg tcctgctgtc gctccggcac tcgatgaccg actcgctggg
     7861 cctcgtcctg gaggccgacc gcgaggagct gttcacccgg atccggctgt cgttcaccga
     7921 ccccggcatc cgtgcccgcg cgatggacga gcagctgcgc aaccaggaag cggtggccgc
     7981 ggcgatcgcg gagcggaccg gccgggacgc cgccgcgctg gacgtgcggt gcgcggcggc
     8041 ggcgatcatc gcggtctcga tgacggtgat gcggcactgg gtggacggcg gcggcaccga
     8101 ggacctcacc gccctgtacg accgccagct gaccaccctc ttcgagggcc tgcggctctg
     8161 acccgccggg gccggccgat caccagcgct ggcgggcctc ctcggcccat cccgtgaggc
     8221 cgtcgaactc gatccaggcg ccgtcgtcgg tgcgggcgcg cccgctgaag tgcccgaagc
     8281 actggtgcgt ctcgctgccg acgagaccga gctcgacccg ggagaccttc tcgtggaacg
     8341 gccggaactc cacctcgacg cggtccccga ggatcgccca ggggcgggtc cagccggacc
     8401 ggtcgtaggt ccattccagc tcgtcgccga tcttgtgcag ccggccgtcg acgaccagcg
     8461 cgttctcggt catgccggtg ccgtcggtcc acttgccgcc gagctggagc gcgatgccgg
     8521 ggccggcggc ggcggcccag ttccacgtca tccggtacgg ccacttgccg cgcccgtggt
     8581 cgaggacggc gaaggcgccc tcgccgacct cgtgctcgcc cgacggaagg acgagccgcc
     8641 cgtggacggg ccgccccacg tccttcaccg tgtactggaa ccgggtgtcg ctccacggga
     8701 tcacgacgcc gagcgactcg tggcccgccg gcagcgggat ctccagctcg atgcggacgc
     8761 cgcgcgcggc ggcgcgcacg gacgtgccgt ccgggcgctg ccggacgccg accgccgctc
     8821 ccccgccgcg gacggcggcc tccccctcgc cgctgcgctc ggggaacgcg gcgccccgcg
     8881 cgaacgggac caccgcgtcc cgcgcgatct cctcgccggt ctcgcggtcg agcacgtaga
     8941 ggccgtgcac gcccgcgtag tccagtgacg acgcgacgag cccgacgatg tgccgcggcg
     9001 tgacgacgcc ccagtactcc cagcgcttcg tgcggcccca gccgcgcagg ttcgcgcggt
     9061 gcaggggccg ccgcgtccag ccgacggccg ccgggttcag acgcccgtcg ggcaggcaca
     9121 ggtcgacggg ctcggtgatc tcgcgctcgt gcgtcggcat cccccgagac taaccgccct
     9181 ttccgggcgg gcgatcggcc gcggcgggcg cccgtcccgg cgggggcggg acgggcgcgg
     9241 ccggcgctca ggacttgtcg acgtggcccg ggacggggtc ggaggcgtgc gggcccgcga
     9301 tgacggtgcc gcagccgccg caggactgct ggacctgctt cagcagcgtc atcttgttga
     9361 gggtgagata gccgatgttc accgtgacag cggtattgtc cgaaaccagc accgcgacgg
     9421 ccgaaatgtt ggttttggtg tagtttccgt aggcggtcgc ctgcgccggc gagccgaact
     9481 cggcgtagga catctgtccc gccgcgttcg ggaacagctc gcccttcttc tcgtagcagc
     9541 tgtattcgcg gtagaacgtc gtctgcttcg agtacggctt gtcgatcgcg aacgtgccgt
     9601 cgttccattc accgtaaccg cacgcgctgt cgcccccgag ggcggtctca cccacccctt
     9661 tgaccaggtc gaacgtcagc ttccgcgccg ccggcgcggc cggcgccgtg ctcttggccc
     9721 ccgtgctctt cgtcgccgcg tgcgaggtcc ccccggaccc cccgcagccc gcgaccagga
     9781 ccgcgctcac ccccatgagc cccaccatgg tcccccaacg tatgccggtt ccccgcatgt
     9841 ccggacttcc tctctgaacg gcctttacgc gaatgatggg ctgttcaatg acccagacgc
     9901 cagggactct ggatcggttc agcccgggac acgcggcgct tcaataagtc catacctcgg
     9961 ccagagtttc tttagtgccg gaccggcgaa tctcacaaag gtgatcaccg attcaccctg
    10021 gagcgcgttc gaccacgacc gcatgctgga cgcgctggcg gcacgggaga actttcccgt
    10081 cgccgcccgg ctgctgcccg cccggcaccg cgccgacctg cgggccgtgt acggcttcgc
    10141 gcgcctcgtc gacgacatcg gggacgaggc gccgcgcgag cagcgcgcgg acctgctggc
    10201 cctggtcgac gacgacctgg acctggtctt caagggcggg acgccgaagc tgccgcagct
    10261 gcgccggctg gccggcacgg tgcacgcgca cgcgatcccg gccgagccgt tccggcggct
    10321 ggtcgaggcg aaccggcagg accaggtcgt ccaccgctac gagacgttcg agcagctggt
    10381 ggagtactgc gcgctgtcgg ccgacccggt cggccgcatc gtgctgcacg tgttcggcgc
    10441 ccagggcgcc gggctggaga gcgcgtcgga ccgggtctgc acggcgctgc agatcatcga
    10501 gcactgccag gacgtcgccg aggaccaccg cgacgggcgc gtctacctgc cggccgagga
    10561 cctgcgccgg ttcggctgcg aggacgccga cctgtcccgc cgggtgacgc cgacgcggct
    10621 gcgcggcgtg ctggccctgg aggccgggcg cgcccgcgac ctgctggacc gcggcgccgc
    10681 gccgctgatg aagggactgt ccggatgggc ccgggtcgcc gtgggcggct acgtggccgg
    10741 cgggcgggcg acgctggcgg cgctggccgg ggcccgctac gacgtgctcg cgcatccgcc
    10801 gcgtccccgc cgggccgccg ttctggccgg gtgggcgcgc gcactgggaa ggggctgagc
    10861 gatgacggtt tcagagacgt gtgagcgcac cgacgagatc gccggggcgt accggcactg
    10921 cgagcgggtg gtgcgcgagg aggcccgcaa cttctcctac gggatacggc tgatgccgcc
    10981 gccgaagcgc cgcgcgatga gcgcgatcta cgcgttcgcg cgcggcgtcg acgacatcgg
    11041 ggacggcccg gagccggcgt gcgtgcggct ggacctgctg gaccggtcgc ggcagcggct
    11101 ggtgaccgtg caggaggtgc tgcggcggcg cagcgacgtg cgggcgctgg agggccatcc
    11161 ggtgctgacg gcgctcgcgg acgcggcggg ccgcttcccg atcccgctcg ccgcgttcga
    11221 cgagctgatc gacggctgcg agagcgacgt gcggggcgcg cgctacgaga cgttcgacga
    11281 cctgctgcgc tactgccagc aggtcgcggg cacggtgggc cggctgtcgc tcggggtgtt
    11341 cgggtcggac ggccggcagc gcgccgaggg cctggcggac tcgctgggcg tcgcgctgca
    11401 gctcaccaac atcctgcgcg acgtccgcga ggaccggatg gcgggccggg tgtacctgcc
    11461 cgccgaggac ctggagcagt tcggctgcac gctggagctg gacgagtcgg gcgtgttcat
    11521 cgacccgccg tggcggctgc acaagctgat cgggttccag gcggagcggg cccgcgcctg
    11581 gtacgcggag gggctgcggc tgctgccgct gctggaccgg cgcagcgccg cgtgcacggc
    11641 ggcgatggcg gggatctacc ggcggctgct ggagagcatc gccgcgaacc cggcggccgc
    11701 gctgaactcg cgggtctcgc tgccgacgtg gcagaaggcc gtggtggcgg cgcgcgcgct
    11761 gacgggggtg gagcggtgag cgtcgtcgtc gtcggcggcg ggctggccgg catcagcacc
    11821 gcgatcgccc tgcaggagac gggtgtcccg gtcacgctgg tggaggcccg cccgtggctc
    11881 ggcggcgcga cccactcgtt ccgccgcgac gagctgagcg tcgacaacgg ccagcacgtg
    11941 tacctgcgct gctgcaccgc gtaccagggg ctgctgcggc ggctccgcgc cgagcacctg
    12001 gtgcggatgc aggaccggtt cgacgtggcg gtgctgcggc cgggcgcgcg gccggcgcgg
    12061 ctgcgcaggt cgccgctgcc gagcccgctg cacatgctgc cgtccctggc gcggtactcg
    12121 cacctgccgg tctccgaccg gctgcgggcg gtgctcgcct cggccgggct gcagcggctc
    12181 gaccccgacg acccggcgct ggacctgcgg tcggcgggcg cgtggctggc cgagcacggg
    12241 cagcggccgt gggcgcgcga ggcgctgtgg gggctgttca tcaccgccgc gctgaacgcc
    12301 gaggtcgacg acgcggcgct cggcctgtcg gcgatggtgt gccggcgggc gctgttcggc
    12361 cgcccggacg ccgccgacat cggcgtgccg accgtcccgc tggcggagct gcacggcggc
    12421 ccggcgctgc gccggatcgc cgagatgggc ggcaccgtcc ggctgaaggc gaaggtcgag
    12481 gcggtcacca ccgacccgaa ggtgatcgtg gacggggtgc cgatcgcggc ggacgcggtg
    12541 gtgctggccg tcccgcacga ggcggcggcg cggctgctgc ccgccgaggc gctgccgcag
    12601 ccgctgcgct ggcacgagct ggacgcgagc ccgatcgtca acgtgcacgt ggtgtacgac
    12661 cggccggtgc tggacgagcc gttcgccgcc gccgtcggct cccccgtcca gtggatcttc
    12721 gaccggtcgg gggtggccgg gctgcgcgac ggccagtacc tggcgatctc gctgtcggcg
    12781 gcggaccgct ggatcgaccg gcccaccgcg gcgctgcgcg cggagttcgt gccggagctg
    12841 gcgcggctgc tgccgggggc gcgcggggcg cgcgtccggg agctgttcgt gacgcgcgag
    12901 cggcgggcga cgttccggca gcggccgggc agccggtcgc cgcggccggg ggcggcgacc
    12961 cgcgcccgcg gcctgttcct ggccggcgcg tggaccgaca cgggctggcc ggacacgatg
    13021 gagggcgccg tgcgcagcgg cctgaccgcc gcacgcctgg tccgccgcca tctggagggg
    13081 gtgagggacc ggtgaccgcc gcgtccgcca cggctcaccc gacccaccgc ttcgagaggt
    13141 gtgatcgatg acggccgttc cggtctcgat gaccgatgtt cgcgggctgg tcgacggggc
    13201 gctgcgcgcc gcggtgggcc ggctcgatcc gcgcacctac cgggtcgcgg cctaccatct
    13261 cggctgggcc gacgaggagg gccgtccgct cgcggcgccc gccgggaagg cgctgcgccc
    13321 ggcgctggcg ctgctgtccg cgcgggcggc gggcgcgccg ccggagagcg cgctgcccgg
    13381 cgcggtcgcg gtggagctga cgcacgcgtt ctcgctcctg cacgacgaca tcatggacgg
    13441 cgaccggacg cgccggcacc gtccggcggc gtggacggtg ttcggggagc ccgccgcgat
    13501 cctggcgggc gacgcgctgc tcgccctcgc cctggaggtg ctccttgaag cgcccgggca
    13561 gggctcggcg cgggcggcgc gcgcgctggc cgtcgcgacg cggcggctca tatcgggcca
    13621 gtcgctcgac ctcgagttcg agacgcgccg ccaggtcggg ctggaggagt gcgcggcgat
    13681 ggcggcggac aagaccgccg cgctgctggc ctgctcctgc gcgatcggcg cggtgctgga
    13741 cggggcgccg gagccgctgt gcgccgcgct ggaggcgttc ggcgccgaca tggggctggc
    13801 gttccagctg gtggacgacc tgctcggcat ctggggcgat cccgccacga ccggcaagcc
    13861 ggcgctgtcg gacctgcggt cgcggaagat gtcgctgccg gtggtggccg cgctgacctc
    13921 cggcacgccg gagggcgcgc ggctcgccga gctgtacgcg aggccgccgg acccggacgg
    13981 gcccggcgag gacgacctcg ccgaggccgc cgcgctcgtc gacgccgccg gcgggcgggc
    14041 ctgggccgag gcggaggccg acaagcggat cgcgagcgcg accgcgcacc tggcgtccgc
    14101 ggcgctgccc gagcccgtcc gcgccgagtt cctgcacatc gccgccttcg tcacacgccg
    14161 ggaccactga tgaccgcgac cgaacccacc gagaccaccg gaaccgcgac cgccgggacc
    14221 gcggagagca ccgccgtccg cacgcccgcc gaggcgatgg cggccgcgcg cgaccacctg
    14281 ctcggcctcc agtcgcccga gggctggtgg aagggcgagc tccagaccaa cgtgaccatg
    14341 gacgccgagg acctgctgat gcgggagttc ctcggcatcc gcaccgccga ggacacccgc
    14401 gaggcggccc gctggatccg ctcgcagcag gcgcccgacg gcacctgggc gaacttccac
    14461 gacgggccgc cggacctgtc cacgaccgtc gaggcgtacg tcgcgctgcg gctcgccggc
    14521 gacgagccgg acgccccgca catgcgccgc gccgccgcgt tcgtccgcgg cgagggcggg
    14581 atccccgcca cccgcgtctt cacccgcttc tggctcgcga tgttcgggca gtggccgtgg
    14641 gagcggctgc cggcgctgcc gccggagatg gtgttcctgc cgcactggtt cccgctgaac
    14701 gtctacgact tcgcgtgctg ggcgcggcag acgatcgtcc cgctgacggt cgtcgcggcg
    14761 aagcgccccg tccggccgct gccgttcgag ctggaggagc tgcggtcggg acgggtcgtg
    14821 cggcgccggc ggggcgcggt ccccggctgg gacgaggcgt tcgccgccct cgaccgggtg
    14881 ctgcgcggct acgagcggcg gccgctgcgc ggcctgcgga aggcggcgct gcgccgcgcc
    14941 gccgagtgga tcatcgcgcg gcaggagccg gacgggtcgt ggggcggcat ccagccgccg
    15001 tgggtgtatt cgctgctcgc gctgcacctg ctcggccacg gcctggacca tccggtggtg
    15061 cggcgcggcc tggaagggct ggagcgcttc accgtccggg atgagaaggg ccgccggctg
    15121 gaggcgtgcc agtcccccgt ctgggacacc gtgctggcga tgaacgcgct ggtcgacgcg
    15181 ggcctgcccg ccggccacca ggcgctcgag gccgccgcgg agtgggtggt cggcgaggag
    15241 gtgcaggggc cgggcgactg gtcggtgcgc cgccccgacc tgccgccggg cggctgggcg
    15301 ttcgagttcg acaacgacta ctaccccgac accgacgaca ccgccgaggt cgtcctcgcg
    15361 ctcagccggg tcgaccaccc gaaggccgag ccggcgatcg agcgcggcgt gcggtggatg
    15421 gcggggatgg tgtccaggga cggcgggttc ggcgcgttcg acgccgacaa cacccgcgcg
    15481 ctgtgccggc ggctgccgtt ctgcgacttc ggcgaggtca tcgacccgcc gtccgccgac
    15541 gtcaccgcgc acgtcgtgga ggcgctcagc ctccgcggca tggccgactc gacgctggtg
    15601 aagcgggccg tcgtctggct gctgaaggcg caggaggacg acgggtcctg gttcggccgg
    15661 tggggcgcca accatgtgta cggcaccgga agcgtggtgc ccgcgctcat cgcggcgggc
    15721 gtccggcccg agaagccggc gatccggcgg gccgtccggt ggctggagcg ccaccagcgc
    15781 gacgacggcg gctggggcga ggacctgcgc tcctaccgcg acccggaatg ggtcgggcac
    15841 ggcgtctcga ccgcgtcgca gaccgcgtgg gcgctgctcg cgctgctggc ggccggggaa
    15901 cgcggcccgg ccgtggaacg gggcgtgcgg tggctcgtcg agcaccagcg cccggacggg
    15961 acgtgggacg aggaccactt caccggcacc gggttccccg gcgacttcta catcaactac
    16021 cacctgtacc gcctggtgtt cccgctgtcg gcgctgggcc gctacgtgaa ggagatcggt
    16081 tcctaaatgg ccatgccact gcgccagagc ctgcgcgtcg gcgggtacgt cctgcggaac
    16141 aagctggcgg ggcggaagaa gttcccgctg atcgtcgagc tggagccgct gttcgcctgc
    16201 aacctggcgt gcgcgggctg cggcaagatc cagcacccgg cgagcgtcct gaagcagcgg
    16261 atgccggtcg agcaggccgt cgccgcgatc cgcgagtgcg gcgcgccgat ggtgtccatc
    16321 gccggcggcg agccgctcat gcacccgcag atcggcgagc tggtccgcga gctgatccgg
    16381 atgaagcggt acgtgttcct gtgcacgaac gccgcgctga tcccgcggaa gatcgacgac
    16441 ttcgagccgt cccggtactt cgcgtgggcg gtgcacatcg acgggctccg cgagcggcac
    16501 gacgcgtccg tgtgcaagga gggcgtgttc gacgaggccg tcgcggcgat ccggatgtgc
    16561 caggagcgcg ggttccgggt cacgacgaac accaccgtgt tcaacaccga caccccgcag
    16621 accgtcatcg acgtgctcaa ctacctcaac gacgacctgc gcgtcgacca gatgatgatc
    16681 tcgccggcgt acgcctacga gaaggcgccc gaccaggacc acttcctcgg cgtgcaggag
    16741 acgcggtcgc tgttccagaa ggcgttcgcc gacggcaacc gcaagcgctg gcggttcaac
    16801 cactcgccgc tgttcctgga cttcctcgag ggcaaggccg acttcccgtg cacggcgtgg
    16861 gcgatcccgt cgtactcgct gaagggctgg cagcgcccct gctacctgat ggaggacggc
    16921 tacgccgagt cctacaagga gctgctggag gagaccgact gggacgccta cggccgggga
    16981 cgcgacgacc gctgcgccaa ctgcatggcg cactgcggct acgagcccac cgccgtgttc
    17041 gcgacgatgg gctcgctgaa ggagtcgctc cgggccgtgc ggagcgtgtg atcagccgtc
    17101 ccgcagctcg cggatgacgt cgcggacgcc cgccgtcagg gcgtccgcgt cgtcgaccag
    17161 gccggtgtcc gcgcagatcc cgaagcacag ctcgccgtcg acgccgagcg cggcgacggc
    17221 gagcggcgcg ccgggcgcga gcgggacgac cgggtacacg ccggtcaccg ggacgccggt
    17281 cagcagcatc cgctcgccgc tcgccggcag gctcgacacg atcccctgca ggaaccggcc
    17341 gccgtagacg gcccgcgcga accgggcgtg cagcggcccc ggcatcagcc gcccgacctg
    17401 ccgcatcacg aaccacgcgg ccagcgcgcg ggtccccgac cgcagcacgc ggctgcgccg
    17461 ggcgatcaag gcgaggcgct cgcgctcggg catcgcgccg atcggcaggt ccaccatgac
    17521 ggcggtggtg tggttgccct ccatgccctc gccgggcgcc cgcatcatca gcggcaccgc
    17581 gacgcggcac tcgcgcggcg gcgtgcccgc cgggaaccgg acggtccgct gcagggcgcc
    17641 cgcgaccgcg cacatcacca cgtccgagac gcgggcgccg taccgccgcg cgatctcccg
    17701 gggctcggcg agcgggatgc gcagggtgcc gaagcggcgc ccggcggtcc ccgcggacgg
    17761 cagccgcggc gcggcgcccg ccccgccgtc cgcggcgagc tgggcgaggc cgacggcccc
    17821 ggcgagcgcc tcccggacgc ggcggcgcgg cggcgccgcc ggcccgcgcc cgccgggccg
    17881 gccgggcgcg gcgggctcca tcagcgagat cgcctgcgcg acgacgccga cgccgtccgc
    17941 gacgacgtgg tgcatcagga agaccagcgt ggtgcggccc ggcgcggccc cggcgaccag
    18001 gatcatccgc cacagcgggc ggtcgcgcgg cagcggctcg gcctggatct cggcgatcat
    18061 cgcgcgcagg ccggccatgc cgtcgacggt gcgctcggtg acgtgccacg accagtcgac
    18121 ggcgggatgg tcgagccaga ccggccggcg ccagcggcct cggtcggcga gccgctgccg
    18181 gaaccgcggc agccgatcga gccggtcgcc gatcagccgg accaggtcga gccggccgag
    18241 cgcgcggcgc gaggtgtcga gcatgatgac gccgcccgcg tgctgcggcg cggcggcgct
    18301 ctccaccgcg aggaagaacg cgtcctgcgc cgggacgcgc tcggccgccg ccggccgggc
    18361 cgccagccgc ccggcggtga gcaccgacag cgccaccagc ggcaccgccg cgaccgcgtc
    18421 caggacgtag tggttggcgg tggcgacgat gacgtaggcg gtcaccgcga tgtgcgcgcc
    18481 gttcagcgcc cgcaccggcc gcggcgcccg tgcccgcgcg agctcgacgc ccgcccacag
    18541 cgtccaggcc atgtgcaggg acgggacggc cgcgaaccgg tccgcgtgct cgatcagcgg
    18601 cgagccccac gacccccacg tccggccgag ccggacggtg tcgacgaacc cgaggtcgcc
    18661 caggaaccgc ggcggcatca ccgggaacag cgcgaagcag gcgatcgcgg cgacgttcag
    18721 cgtcacgaac gcgttgcgcg ccgtccggta ccgctcggga tgccgcacgt acagccagac
    18781 cagcaccgcg agcgtcgcgg cgacgtaggt ggtcgcgtac tcgtagtcgg cgaggacgcg
    18841 ccagacgggc cgtgcggcga gccagccgtt gagcgccggc tccaggtcga ggtgcagggc
    18901 ccgctcgagg ccgagcacca tctccccgcg gcggcgggcc gcgtgctccc tgacctgctc
    18961 cggcagcatc gccaccaggg agtacaggcc gaacagcgcc agtccgagca gcacctcgcc
    19021 gctggcccgc ccccgcgttc cggctccgtc ccgggtgagg accgcgtcgc gcgcggtcac
    19081 cgcgtcctga gtccccatcg tccccccgca cggctgttac ccagcatttc cgccggtcag
    19141 acggccatga ccggaataga tgatcatgtc cgggatgtcg gcggacgcgg gccgcgcgct
    19201 ccggcgcggc ggatccggga actctctggc ccgacgaggc atctacgata tatcgttgtc
    19261 gtatcgcgag ggatcaaaga gaggtctcag aaggaaggtg cagaacatgg gagcggcaca
    19321 tcggcacggc gggcccgacc tcggctgggc gttcgcggcg gcggccctcg gcgcgaaggc
    19381 cgcccacgcg gcggcccggc accacgggca cgggcacggt gcgggcctcc ggggcgactt
    19441 ccccggcttc ggcccaatgt tcggcggtgg acccggcggg ccctgggggc ccccaggcgg
    19501 gttcgggccc ggccgggcgc cctgggcgcg cgggcgcggc ccctggggcc ggggaccgaa
    19561 ggcgcgcaag ggcaacgtcc gcgcggcggt cctcgtcctg ctcgccgagg agccccgcaa
    19621 cggctaccag atcatccagg agatcaacga gcgcagcggc ggcgcctgga agccgagccc
    19681 aggcgcggtc tacccggcgc tgcagcagct cgccgacgag ggcctcatcg cgggcgagga
    19741 gggcggcggc cgccgcacct tccacctcac cgacgagggc cggacctacg tcgaggagaa
    19801 cgccgagcgg ctcgccgagc cgtgggcgga gatgacgccc gagttcggcg agggcgtccc
    19861 cgagctgttc aagcaggccg cgcagacggg ggccgcggtc atgcagatcg tccactccgg
    19921 ctcccccgac caggtcgccc aggcccggga cgtcctgtcg gaggcgcgcc ggaacctgta
    19981 ccggatcctg gccgacgacg cccccgcggg cgcctccgac ggcgacgacg cgggcccgac
    20041 ggccgacgac gacgaggagt agaccagtga ctcgcccgga cgacatccgc atcggcgacg
    20101 ccgagcggga cgccgtgatg gtcgccctgc acgaccactt cgcggcgggg cggctcgacc
    20161 gcggtgaact cgacgagcgg ctggacgccg tgctgtccgc caagacccgc ggcgacctgc
    20221 gcaccctcgt gcgcgacctg cccgcgccga ccggcctgcc cgaaccgggc gggccggcgg
    20281 cggccttcgg caacgtcccc tggggcgccg gccacgcggt catgttcggc ggcccagggc
    20341 accccatgca ccaccgccac caccgccacc gccacttggc gcaccaccgc cgtcacggcc
    20401 cgcacttcgc gttcccgctg atgctggccg tgttcctcgt ggtcacgttc accgtgggcg
    20461 tgggcacggc ggcgctggcc gtcctgcaca tcgcgctggc catctggctg gtccgcgcgg
    20521 tcatgctcct gaccggcgcc cgccggtccc gccgccacct cacccccggc gcctgacccg
    20581 ggacggaccg cccgcttcgg cgggcgggca ggccggcccg ggcccgcggc cgggccggcg
    20641 ccgccccgcc gtcaggcggc ggggcgttcc ggcgggagcg cgcagcggga cgggacggcg
    20701 tcgcggagcg cgccgagggc gcgggcgatc agcgggttcg cgcggctgcc ccgccggacg
    20761 caggtcagca cctgccgcat cggcacggcg tcgccggaca gcgggacgcg cacgaccggc
    20821 tggtcggccg gcccgtccgc cagccgcggg accagcgaca cgccgagccc gttgccgacc
    20881 agtgcccaga tcaccgacca ggtggtggcg ttgtgcgcga tccggggcgt gaagccggcg
    20941 gccgcgcagt aggccatcac ctgctggtgg tgggcgcagc ccgcgggctg gacgctgatc
    21001 cacgcctcgg ccgccgcgtc ctccagccgg acgtcgcggc ggcccgcgaa cgggtgcccg
    21061 gcggggacga tcaggtcgag cgcctccgcc atcagcggtt cgcggtcgaa gcgcgggtcg
    21121 ccgggcggcg gcgcgtccgc ggtcggctcg atgacagcga cgtcggtctc gcccgccgcg
    21181 agcaggccca cggccacgtc ggtgtcgcac tcgcggatct cgatcgccag ggccgggtcg
    21241 gcgcgcagca gcgcgccggc ggccggggcg accaggccgc cgaccgccgt ggtgaacccg
    21301 cacatgcgca gcggcccgtg ggcgcccgcg cggtgcgact ccaggtcggc gagcgcctcc
    21361 tcccagcggg cgagcatggc gtcggcgtgc tcgatcagca ggtgcgcggc cggggtgagc
    21421 cgcacgcggc ggccctgcgg ttccagcagc gggaccttga gctcgcgcgc cagttcgcgc
    21481 aggtggtggg agacggcgga cggggtgagg tgcagcgcgt ccgccgccgc ggtgaccgtc
    21541 ccgtactggt ggacgagccg gagcatgtgc agccgccgca ggtcgatcat gcaatcatct
    21601 tgcacatacg ggtgcggaaa tgtgaaatgg acggcaacgt tcgaggctgt gcagactgcc
    21661 gtcatgacac agcgagacag ggtcctttcc cggcatctca ccagtgacgg cgtcgtcgtg
    21721 tggagccgct gctcctgcgg gcggctgcgg atggacctcg tcccggcggc gggcgggccc
    21781 cggctgggcg ccgggccgtg cccgcaccgg gacggcggtc acacgtcgag cgtcagctcg
    21841 tagtgcagcg tcctgtagcg cttcacccgg tggaggaggg ggacggcgaa gccctgctgg
    21901 aagcggtgct tgcgcgccag catccggcgg atcggcttcg cctcgtcctc gccgagcagg
    21961 cgcacgcggc cgtgcaccgc ggggccggtg accttgccgc tgtaggtgct cggcgcgatc
    22021 tcgacctcgg ggttccgggc catccgcttg gtcttgtacg ccttgtcgta ggtgcggaag
    22081 taggcgtggt cgccgcggac gacgacgttc accggcgtcc cgaccggcgt gccgtccttg
    22141 cggtaggtgg tgagcaggac ggtgcgctgc cgcgccaggc cgtcgagcgt ctcgcggatg
    22201 ttcgtggcgt ccattgcggg cctcccttgt tctcgctcct gcccaggaga cgggagggag
    22261 acccgcggac gtgacatcag ctcgggcgca gggcggcggc ctcggcggcg agcgcgcgga
    22321 tccggtccca gtccccggcg gcgacggcgt cggacggggt gagccaggtg ccgccgacgc
    22381 agccgacgtt cggcagcgcg aggtagtcgg cggcgttgcc gggccggatc ccgccggtcg
    22441 ggcagaacgt gatccgcggc agcggcccgc cgagcgcctt gaggtagggg acgccgccgg
    22501 ccggctcggc ggggaagaac ttcatcgcgg tgatcccctc ctccagcagc gccatcgcct
    22561 cggacgcgct ggagacgccc ggcaggaacg gcaggccggt gcccgccatc gcggcgcgca
    22621 gccggggcgt gcagccgggg ctgacgagga accgggcgcc cgccttgagc gaccgctcgg
    22681 cgtcgtccgc ggtgacgacc gtcccggcgc cgacgacggc gtccggcacc tcggcggcga
    22741 tccgctcgat cgactcggcg gcggcggggg tgcgcagcgt cacctcgatc gcggggaggc
    22801 cgcccgcgac gagggcgcgg gccagcggca ccgcgtgggc ggcgtcgtcc aggacgacga
    22861 ccgggacgac gggcgccagc ccgagcagct cttcggtgtt catgcggtct ccagtgtctc
    22921 cagggcggcg ggggtctgcg ccagccggac ggcggcgccg aggagggccg ggttcggatg
    22981 gacgatcagc gaggtcggga tcgcacgcat atagtcctcg accggcggct tggcctcgaa
    23041 ccgggcgcgg aagtcgctgc ggcgcagctc gtccgcgatg cgcgggagga tgccgccgcc
    23101 gaggtggacg ccgccgcgcg cgccgagcgt cagcgccacg ttcccggcga gcgagccgag
    23161 cagggcgcag aacatcccga cggcctccgc gcagaggggg tcgtcgccgt gcgcgcagat
    23221 ccgcgcgggg tcgaggggct cggcctgcac gccgtcgagc atcgccaggt agcggtggat
    23281 gcgggcgagg ccggtgcccg acagcaggga ctcggcgcgg gcggcgccgt gctcggcgcg
    23341 cagcagccgc gcgaccgcca gctcccggtc ggtcgcggcc gggacgtcca cctgcccgcc
    23401 ctcgccgggc agcggcaccc acccggccgc cgtcgggacg agcccggcga cgccgaggcc
    23461 ggtccccggg ccgacgaccg cgagcggcgc cgcctcggcg gtccgcgcgg cggggccgat
    23521 cgggatcacg tcgtccgggc ccaggcgcgg cagggcgagg gcgagcgcct cgaagtcgtt
    23581 gaggatctcc aggtgcggga cgccgaggtg ctcgcgcacc tgctgccgcg tgcccttcgg
    23641 ccagcccgcg ttggtcaggt ggtagccacc gccggtgacg ggtcccgcca ccgccaggca
    23701 cgccgccgtc gggcggacgt ccggggcgta ccggtcgagg taggcggccg cggcctcggc
    23761 cagccccgcg tggtcgcggg tgggcagcga ccccacccgg tacggggcgc cgtccgggcc
    23821 gtccaccagc gcgaaccggg cgttcgtgcc gccgacgtcg gcgaccagcc aggtcccggt
    23881 catgcgaaca cccccgcgcc gagttcggcc gcgccgacgg agcggcggaa cacctcgaac
    23941 agctcccgtc cagtgcccgt cgactccccg gcggacggcg ctgcggctga ggggatgcgc
    24001 gcgtcgaact cctcgtccgg cacgagcacc tccagcagcc ccttgtcggc gtccagccgg
    24061 acgacgtcgc cgtcgcggac gcgggcgagc gggccgcccg ccgccgcctc cggcgacacg
    24121 tggatcgcgg cgggcaccgc ccccgaggcg cccgacatgc ggccgtccgt gaccagcgcg
    24181 acccggaacc cgcggtcctg gagcaccgac agcggcgggg tgaggcggtg cagctccggc
    24241 atcccgttgg cgcgcggccc ctggtgccgg acgaccgcga cgacgtcccg gtccagctcc
    24301 ccggcggcga acgcctcctg cagcgcctcc tgcgactcga acacccgggc gggcgcctcg
    24361 atcatgcggt gctccgggct gaccgccgac accttgacga ccgcgcggcc caggttgccg
    24421 ttcacggtgt gcaggccgcc gtgggtgtcg aacggctcgc cggcggggcg cagcacgtcg
    24481 gtgtcgccgg actcggcggg cgcgtcctcc cagaccaccc gtccgccgtc catccgcggg
    24541 acccgccggt acgcggcgag cgtggcgccg ccgacggtcc gggcgtcctc gtgcagcagc
    24601 cccgcgtcga tcagctcgcc gatgaggaac gcggtgccgc ccgcggcgtg gaagtggttc
    24661 acgtcggcgg tcccgttcgg gtagagccgg gtgagcagcg gcgtcacctt cgacagctcg
    24721 tcgaagtcgt cccaggtcag ctcgatgccc gcggcggcgg ccatcgcgac caggtgcagc
    24781 gtgtggttgg tggacccgcc ggtcgccagc agcgcgacga ccgcgttggc gaacgcgcgc
    24841 tcgtccagca gctcgccgat cggggtgtac tcgtccgcga ggtcggtcag cttcaggacg
    24901 cggcgcccgg ccgcctcggt cagcccgtcg cgcagcggcg tgcccggcgg gacgaagctc
    24961 gcgcccggca ggtgcaggcc catgacctcc atgagcagct ggttggagtt ggccgtcccg
    25021 tagaaggtgc aggtgccggg cgagtggtag gacgcggact ccgcggcgag cagctcgtcc
    25081 cgcccgatct cgcccgccgc gtaccgcttg cggaccttgg ccttccgcgc gttcggcagc
    25141 ccggacgcca tcggcccggc cggcacgagg atcaccggca ggtgcccgaa cgccagcgcc
    25201 ccgatgacca gccccgggac gatcttgtcg cacacgccga gcagcagcgc gccgtcgaac
    25261 atgtcgtgcg acagggccac cgccgtcgcc atcgccacca cgtcccggct gaacagcgac
    25321 agctccatgc cggcgcggcc ctgtgtgatg ccgtcgcaca tcgccgggac gccgccggcg
    25381 aactgcgcgg tgccgcccgc gcggcggatc gcggccttca ggatgtccgg gtagtccttc
    25441 aacggctggt gcgcggagag catgtcgttg taggccgaca cgatcgcgat gttcggcgtg
    25501 acgttcccgc gcagccacag cttgtcctgg acgccgcagg ccgcgaaccc atgcgccagg
    25561 ttcgcgcacc ccatgccgcc gcgcgccggg ccctgcgtgc gggcggcgcc gatgcggtcg
    25621 aggtaggcgg tgcgccgggc ggcgctccgc tcggcgatgc gctgtgtgac gcgttccaag
    25681 acggggtgca aggccatcgc aagctccaga ccagggggat cggtagatcg ccaaactatc
    25741 gagacatacg tcacccatac aagccgactt atgaacttca actgacaaaa gtccgacggt
    25801 tcgaccaact ggacgcaccg aacacgggcg tgcttgactg accggatgcc gcgccccgtg
    25861 acccgcccgt gcacgaccgg cgacgtgctg cgcctcatcc gcgaggacgg cgtcgccacc
    25921 cgcgccgagc tcggccgcgt caccggcctc tcccggcccg ccgtcgcctc ccgcgtcgcc
    25981 gacctgatcg gccgcggcct cgtcgtcgag cgcgccgacg gcccgtccac cggcggccgc
    26041 cccccggccc ggctggagtt caacgccgcc ggcggcgccg tgctgg
//
