LOCUS       NZ_CP053892            21386 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2346249
            Orig. end                         :: 2367635
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..21386
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21386
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21386
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11386](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11386
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            541..1284
                     /locus_tag="ACTIVE_RS09895"
                     /old_locus_tag="ACTIVE_1976"
     CDS             541..1284
                     /EC_number="3.1.-.-"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631645.1"
                     /locus_tag="ACTIVE_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1976"
                     /product="dienelactone hydrolase family protein"
                     /protein_id="WP_173094772.1"
                     /transl_table=11
                     /translation="MTDQMQAGTVAITGHEGAELEAYLARPLGDRPRGGVVVIHHLPGY
                     DEGTKQITRAFAARGYAAILPNLYSREGKGVSPDDQAAAARAKGGVPDEQLVGDVAGAA
                     AHLNSLEGANGKVGVIGYCSGGRQSFLAAVSLDLDAAVDCYGAFVVKEPPADFPLKAGP
                     LIAKAGDLSCPLLGLFGEDDQFPAPDEVAELDAELTRLGKEHEFHSYPGAGHAFFAVER
                     ASYRPEAAVDGWKRIFDFYGRHLAS"
     gene            1298..1582
                     /locus_tag="ACTIVE_RS09900"
                     /old_locus_tag="ACTIVE_1977"
     CDS             1298..1582
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) triceptide_precursor"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631644.1"
                     /locus_tag="ACTIVE_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1977"
                     /product="DUF6295 family protein"
                     /protein_id="WP_173094773.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCTYQTHKVELAGAAKGAAGWFTLTDGAVYVDHPFHSTHEHTLNI
                     DFTNPSEGPSARVAVELTEEAALALVEAVQKALASAPPGMASAAGPRGA"
     misc_feature    1627..1643
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
     gene            1709..3751
                     /locus_tag="ACTIVE_RS09905"
                     /old_locus_tag="ACTIVE_1978"
     CDS             1709..3751
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="ACTIVE_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1978"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_173094774.1"
                     /sec_met_domain="Pkinase (E-value: 2.2e-37, bitscore:
                     127.9, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPLLADDPRRIGGYTVVERLGAGGMGTVYLGRSASGLPVAIKVI
                     HAGRSGEAAFRARFAREVTAARAVGGAFTAPVIDADPAAEDPWLVTAYLPGMSLQQAVA
                     EHGALPVPAVFGLGASLAEALVSVHRAGVVHRDLKPANVMLAPDGPRLIDFGIAHAAGE
                     AVVTRTGHMVGSPGYLAPEQAAGDGTGPAADVFALGAVLAFAATGEGPFGRGRAEVLIY
                     RVVHDPPRLDAVPDAGLRALIADCLAKRPELRPAAADLVPRFAARAPAVEVLQGTSWLP
                     APVADGIGAAERSLAGLGRDRRAFLKAGAAAGAVAVLAGAAAAGTVLARGHGSPKKAAA
                     GTSPSAAPTPATPPDAVQVWQHDIGTDPFGGLAVADGMLLVSADDGRLIALDARTGEQR
                     WQHKKSGRDGGAAGWRTPVVSGGVLYVGWPDTEGTLYAYDVKTGKEKWRTVLPGDPREP
                     GAGDGLVVVDAGDLVALRASDGSRRWHRNIGNVQDVTPAVAGGSVFTADASTVYALDAG
                     DGRVRWRHRIGSGGDQYARSSPVASGGMVFCGSGDATLVALDAASGAERWHFLGGTSVG
                     EPAVAGGVVFVGDGSGNMNALDARTGATRWRLATGDESVGQASVDGGVLCFLTKNWGFG
                     VDAASGRALWKTAVGGGVRADVAADGLYHVGFESGQIMTLAVKGT"
     gene            3752..5911
                     /locus_tag="ACTIVE_RS09910"
                     /old_locus_tag="ACTIVE_1979"
     CDS             3752..5911
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019334.4"
                     /locus_tag="ACTIVE_RS09910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1979"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_173094775.1"
                     /sec_met_domain="Pkinase (E-value: 2.9e-38, bitscore:
                     130.8, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPLRAGDPPRIGGIRLLARLGTGGMGRVFLGRTAAGRPVAVKVV
                     HPDLAGDPGFRARFAREVAAARAVGGAFTAPLIDADPDAPRPWLVTAYLPGRSLQEAVD
                     GHGPLPPASVRALGAGLAEAIVAIHRAGVAHRDLKPSNVMLTPDGARVIDFGIARAAEA
                     ATVTRTGTAVGSPGYMAPEQAAGPGAGPAGDVFALGAVLAFAATGTGPFGRGAVHELVY
                     RVVHEPPRLDGVADPDLHAAIAGCLAKDPELRPSAAAVLERLAALAPAAPHGVAWLPPP
                     VASDITRPVPMPAGTRDAADGGPASPARRRPLVGGAAGAAAPLAGGAALTATGLPGGGG
                     AEAGAADGVWVYDPKGTFSGGPVVLGDLVFATTGIGAATLHAVDRRTGRKRWSAGGVRS
                     PGDLFPLGVAAYGGVVYAPGDDEIIALDRGTGRALWAAPTPGGYTLEAPVIGAGLLFAP
                     QSDAESVVEAYDGRTGARRWVFDTGGFVRTPLMTDGSLLYALAEGTVFGVEAVSGRVRW
                     RHGLGRRVEVVGTPAAAGGALYVIDTKSVLYALDAATGKARWTQRKGGPGSASPQTAVS
                     VSGGTVFTGDGSRTVSAFRARDGRPLWRHAFPGRNPDGRRLLPLVASGVAIFSFDESLV
                     ALDAATGRVRWQAGGLTGPDQRPVLAAGAVHLAGWDAVVSYDPATGRLLHRRPRTNLEA
                     ENLTAAGDVIYWTDGEGLHAAKAPH"
     misc_feature    5950..5963
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.82"
                     /tool="antismash"
     misc_feature    5951..5964
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.5"
                     /tool="antismash"
     misc_feature    complement(6190..6203)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.41"
                     /tool="antismash"
     gene            6206..7261
                     /locus_tag="ACTIVE_RS09915"
                     /old_locus_tag="ACTIVE_1981"
     CDS             6206..7261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654750.1"
                     /locus_tag="ACTIVE_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1981"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_173094776.1"
                     /transl_table=11
                     /translation="MLREPLPRNPRPVRAAAAAAAAAALALTAAGCGTSARGATGTVKI
                     GYFQGAVAGPEAVVAADKGLSAKVPGKIELRPIDSGVAGMAQLRAGAFPFVAGVGNPPF
                     TGAFTSGTDVKAVYVEGIDASGLAVHGTIRTPRDLRKVGVLVGSTLDFQLRGWLKSQGL
                     AGAVQIASFASEAAEAAAWKAGKIDAVYISQSFLLELQKHKARVLVRSTDIAKLGYAAV
                     NMLAVSTPYARQHPEVVQALVCQLSKAEALVKGPQADKYIAPAAKFVGVAPADAIAATK
                     SYPYIPASEEGAWLKGPDGTAATGKLAQNFKLTAEFLVTQGRAKTVPDPARIARHIDPS
                     FWDKAQSGGCK"
     gene            7258..8076
                     /locus_tag="ACTIVE_RS09920"
                     /old_locus_tag="ACTIVE_1982"
     CDS             7258..8076
                     /EC_number="7.6.2.7"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630160.1"
                     /locus_tag="ACTIVE_RS09920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1982"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_246342750.1"
                     /transl_table=11
                     /translation="MSTIETRPAIAGPAADGGGDEPAGVRLRDVRKTFGRRRRPGRPAL
                     DGVTLDVRPGEFLCLLGPSGCGKSTLLNIVAGFTAADSGEVLVGGRPVTGPGHDRGVLF
                     QTPNLFPWLTTWQNVLYGPKARGALTPRVREEAERLLETVGLADARDAYPHELSGGMRH
                     RAAFARVLVNRPGVLLMDEPFGALDAITRAAMQRFLLELWQEHRTTIVFVTHDVEEAAL
                     LGDRVCVLSAPPAGTKDVIDIELPRPRAYEDTETLAFVNAKRRIREVLER"
     gene            8073..8906
                     /locus_tag="ACTIVE_RS09925"
                     /old_locus_tag="ACTIVE_1983"
     CDS             8073..8906
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630159.1"
                     /locus_tag="ACTIVE_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1983"
                     /product="ABC transporter permease"
                     /protein_id="WP_173094777.1"
                     /transl_table=11
                     /translation="MTATTEAPAATAVAGPAHGSPRSWRRVGTGAGAIALALAVWEVAA
                     LVIGDSVTLPTVTETARTLAEYLGKPYPEVQGRTLVADALISTGRILAGFLLGTAAGLA
                     LGASMAGIRVVRELADPLIAIMRPLPPIAFIPLLVVWFGIGETSKIALIFFGVLPIVTV
                     ATLGALDAVPPDLLNASRSLGASPLRTMLHVRLRAAVPGVITGMRIAMGGAWTAIIAAE
                     MIAATGGVGYLILQAGNYLQTPLIFSGIAEIAVLGFAFDGLLRLLLRLADPTVRR"
     gene            8921..9814
                     /locus_tag="ACTIVE_RS09930"
                     /old_locus_tag="ACTIVE_1984"
     CDS             8921..9814
                     /NRPS_PKS="Domain: TauD (4-262). E-value: 6.2e-61. Score:
                     198.4. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS09930_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654747.1"
                     /locus_tag="ACTIVE_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1984"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_173094778.1"
                     /sec_met_domain="TauD (E-value: 9.5e-59, bitscore: 198.4,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEFRRIGGRIGAEYTGTDPNDLPFEEVNDALLAHKVLVFRGAGL
                     DDEGQLRFAARFGELTRAHPTVPSVDGQPDILPVNGEEGIRSNNWHTDVTFVRTPPKLS
                     TLRALVVPPYGGNTLIANSAAAYRDLPEQLRDFADRLWAVHTNDYDYAVPRSNTEKALE
                     YRKVFTARRYRTAHPVVRVHPETGERGLFIGGFAQEIVGLSGTESRDILRLLQRYVTRP
                     ENIVRVAWNPGDLVLFDNRITQHYAPDDYGDLPRVLHRVTVAGDAPVGVDGESSRILEG
                     DDAGHYTPAAAATAAA"
     aSDomain        8933..9706
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS09930_TauD.1"
                     /evalue="6.20E-61"
                     /label="ACTIVE_RS09930_TauD.1"
                     /locus_tag="ACTIVE_RS09930"
                     /protein_end="262"
                     /protein_start="4"
                     /score="198.4"
                     /tool="antismash"
                     /translation="RRIGGRIGAEYTGTDPNDLPFEEVNDALLAHKVLVFRGAGLDDEG
                     QLRFAARFGELTRAHPTVPSVDGQPDILPVNGEEGIRSNNWHTDVTFVRTPPKLSTLRA
                     LVVPPYGGNTLIANSAAAYRDLPEQLRDFADRLWAVHTNDYDYAVPRSNTEKALEYRKV
                     FTARRYRTAHPVVRVHPETGERGLFIGGFAQEIVGLSGTESRDILRLLQRYVTRPENIV
                     RVAWNPGDLVLFDNRITQHYAPDDYGDLPRVLHRVT"
     misc_feature    complement(9930..9950)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.86"
                     /tool="antismash"
     gene            10001..11386
                     /locus_tag="ACTIVE_RS09935"
                     /old_locus_tag="ACTIVE_1985"
     CDS             10001..11386
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041167.1"
                     /locus_tag="ACTIVE_RS09935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1985"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_216858365.1"
                     /sec_met_domain="T1TS (E-value: 8.9e-52, bitscore: 176.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDERSAARGPGCGTDGPARGTGAGARTADGDAAAERVRRLLSGPT
                     GPGTSAARLLDALRTVPPPPETAAPPAPLDGTEAPSEREPDADAPEAPDAQAPQDARDA
                     QDPCAAEPEAAVPVLPTPLPSPTRKGGHFSPGYAEREWGDGSYPPLYCPLTARIDDDLA
                     LVVNDRLVEWAGEVGIYADQMDKFRNTGFGRLAVLAHPEADDVDPLLLAAKMNAAWWAC
                     DDYYADETDLGAVPTQLPPRLALVMSAMDPPPDAGKYTVQVEEAVESDPVLRALRSATG
                     HLKRHAGPSQVMRILNTTFQMYVSWTAYAAWRHLGELPPVWRYLAARQHDSFYTSMTLI
                     DVVGGYQLDANLFYEPRVHRAVMQAGTASVIVNDLHSVEREAADDLPDCNVVLLIAEEE
                     GCALEDAVRAAVAMHNDFVRGFEDSQRELASLPSAELQRFLLGVQSWMAGCLEWHGASD
                     RYK"
     gene            11506..12360
                     /locus_tag="ACTIVE_RS09940"
                     /old_locus_tag="ACTIVE_1986"
     CDS             11506..12360
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (87-190). E-value: 1.1e-09. Score:
                     28.7. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS09940_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153643.1"
                     /locus_tag="ACTIVE_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1986"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_173094779.1"
                     /transl_table=11
                     /translation="MTATQDSPVLGSLYQHSVAEYWNAERNPVNLRLGEVDGIYHHHYG
                     IGAVDWTVLDGPAETREQRTIAELHRLESAQADLLMSHLGPVKPSDRLMDAGSGRGGSS
                     LVANERFGCRVDGVSISESQVAFANDQAERRGVADKVRFHFKNMLDTGFETGAFQAIWN
                     NESTMYVELGLLFAEHARLLRRGGRYVTITGCYNDAYGLPSRAVSEINAHYICDIHPRS
                     TYFREMAANRLVPVSVVDLTSATIPYWELRAKSTLATGIEQAFLDAYKGGSFQYLLIAA
                     DRI"
     aSDomain        11767..12075
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS09940_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.10E-09"
                     /label="ACTIVE_RS09940_oMT.1"
                     /locus_tag="ACTIVE_RS09940"
                     /protein_end="190"
                     /protein_start="87"
                     /score="28.7"
                     /tool="antismash"
                     /translation="KPSDRLMDAGSGRGGSSLVANERFGCRVDGVSISESQVAFANDQA
                     ERRGVADKVRFHFKNMLDTGFETGAFQAIWNNESTMYVELGLLFAEHARLLRRGGRYV"
     gene            complement(12451..13125)
                     /locus_tag="ACTIVE_RS09945"
                     /old_locus_tag="ACTIVE_1987"
     CDS             complement(12451..13125)
                     /NRPS_PKS="Domain: Abhydrolase_1 (32-131). E-value: 1e-11.
                     Score: 36.9. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS09945_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853883.1"
                     /locus_tag="ACTIVE_RS09945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1987"
                     /product="triacylglycerol lipase"
                     /protein_id="WP_173094780.1"
                     /sec_met_domain="PF00561 (E-value: 2.4e-08, bitscore: 33.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.3e-06, bitscore:
                     27.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRILGTLLAAAVTVLGAVVGVSAPAQAAGHTPVVFVHGYTGNAS
                     NWVTAEAVFAAAGYSSNEMFAFNYNSYGDNKTNAASLASYVNQVRAQTGASKVDIVNHS
                     MGGLVSWWYIKELGGQQYVRHLASLAGANHGTTAAYACLIYTTCQQMSPGSSFIQTLAS
                     GDETPGDTKYATWYSPCDGVINPYTSTMLSGATNNYVACENHLTYLTDTTVLNAVRTFL
                     AS"
     aSDomain        complement(12733..13029)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS09945_Abhydrolase_1.1"
                     /evalue="1.00E-11"
                     /label="ACTIVE_RS09945_Abhydrolase_1.1"
                     /locus_tag="ACTIVE_RS09945"
                     /protein_end="131"
                     /protein_start="32"
                     /score="36.9"
                     /tool="antismash"
                     /translation="PVVFVHGYTGNASNWVTAEAVFAAAGYSSNEMFAFNYNSYGDNKT
                     NAASLASYVNQVRAQTGASKVDIVNHSMGGLVSWWYIKELGGQQYVRHLASLAG"
     gene            complement(13284..14240)
                     /locus_tag="ACTIVE_RS09950"
                     /old_locus_tag="ACTIVE_1988"
     CDS             complement(13284..14240)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544719.1"
                     /locus_tag="ACTIVE_RS09950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1988"
                     /product="ATP-dependent DNA ligase"
                     /protein_id="WP_173094781.1"
                     /transl_table=11
                     /translation="MSTEEERDGVRLTNLDQPLFAGAEATKRDLVDYLDAVAGRLVPRL
                     AGRPLSVVRVLRGQKPFMQKNLPKYTPPWVRRVTVWAETSQRDVSYALCDDRRTLLWFA
                     NQRAVEYHPPLVLAADPGLPTHLVIDIDPPEGAPFAAAAGAAHLVRRALGDCGLDGAVK
                     TSGSKGVHVVVPLDGRTAADDAAAATRALAARAERLDPALATTAFIREDRAGKVFLDST
                     RAGGATVAAAYSPRIRPGTPVSFPVPWDGLDAADPRAFTVRTAARLLADRDLWAELMPA
                     ARPLPADLVAEGHTIPIARVQAMHEGKRRARARRDQG"
     gene            14292..14945
                     /locus_tag="ACTIVE_RS09955"
                     /old_locus_tag="ACTIVE_1989"
     CDS             14292..14945
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132952.1"
                     /locus_tag="ACTIVE_RS09955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1989"
                     /product="FMN-binding negative transcriptional regulator"
                     /protein_id="WP_173094782.1"
                     /transl_table=11
                     /translation="MYIPAHFSAGDAEVRALLDGCGAADLVTSTPRGLVATFLPVLYDP
                     DAGEHGALLAHVARNNDQWKEPAQGESLVVVHGPDAYVTPSWYASKAEHGRVVPTWNYL
                     TAHVYGRLVVHDDPAWLESLVRRLTDKHEAGRPDAWSVDDAPPEYIAGQLRAIVGLELV
                     ITRIEAKAKLSQNRPGADRDGVAAGYLADGDPAMAEAVRAAAGRAAAGPEAPGR"
     misc_feature    14303..14319
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            14942..>17575
                     /locus_tag="ACTIVE_RS09960"
                     /old_locus_tag="ACTIVE_1990"
     CDS             14942..>17575
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851222.1"
                     /locus_tag="ACTIVE_RS09960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1990"
                     /product="AAA family ATPase"
                     /protein_id="WP_173094783.1"
                     /transl_table=11
                     /translation="MNARTVSPVLVGRERESAALDAAFRAARDGTPSAVLLGGEAGVGK
                     TRLVAEFGARARAEGARVLVGGCLELGTEGLPFAPFTAALRGLVRDVGVDGVRGLLPAG
                     AGDGLGRLLPDFGDADAGAFTAESRARLFELVLTLLERLAASGPVVLVVEDAHWADAST
                     RDLLTFLVRNLGAGDALLVVATYRTDELHRTHPLRPVLTELERVEHVARVEVGRLGRDE
                     VGELVRGILGADPPAGTLTEVFGRSEGNPLFVEALVGSGAGHDLPESLRDLLLGAVQRL
                     PEDTQEILRVAAGGGARIEHELLAAVAGLDERELTRGLRPAVAANTLVVDGDGYAFRHA
                     LIREAVHDDLLPGERTRLHVRYARVLEERPELMPDRARAVTLAYHWHAAHDVVRALTSA
                     WLAVGETRRALAYAEALRMASRVLGLWERVPDAAERIGVPHVQVLEEAVELADLAGEPD
                     TGVRLATEALRHVDASAEPVRAARFYELRGMMRLRAGSDKAPADLREAARLVPADPPSA
                     ARARVLATLATRITGLHGTLGEALDTAREALEVARAVGDAEAGLSVELNLAWLDLFDQD
                     DPEAFIARIGRIGEQAARAGAFEPLLRAITNHSDVLEMYGRHEEAAKVAAEGVARAEEH
                     GLARSAGAFLSINAAEPLMLLGRWDEALGVVGRTLPRTSAGVIRAGLHNLAGTIALARG
                     DLAAADRHAAETPGLIARGAARRTQNLFPVCRLLALIALAHGRPAEALDALEPILTDVG
                     LPDDSRYAFPGLVVAATACAELGDTGALAAARTRVEGLRVYGPVQEAHRLTFTAEAARA
                     EGVLDEAAWDAAAAAWDALHQPYETASALVRVGEARLAGGHRDRAGAALRRAADLAAGL
                     GAEPLRD"
     assembly_gap    17576..17600
                     /estimated_length=25
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <17601..17867
                     /locus_tag="ACTIVE_RS09965"
     CDS             <17601..17867
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629089.1"
                     /locus_tag="ACTIVE_RS09965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_216858366.1"
                     /transl_table=11
                     /translation="LRDRAADLARRAGTPAGGERPAPGLGLTPRETEVLRLVAAGRSNR
                     EIAEALFISVKTASVHVSNILGKLGVAGRGEAAARAHRLRLFD"
     gene            complement(17892..18968)
                     /locus_tag="ACTIVE_RS09970"
                     /old_locus_tag="ACTIVE_1992"
     CDS             complement(17892..18968)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS09970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_1992"
                     /product="hypothetical protein"
                     /protein_id="WP_173094785.1"
                     /transl_table=11
                     /translation="MAAAHRTTTRNRARDGADRRLLGALESLYVIPPGHHRPDTGRAEA
                     ARLLACDDRTLTALVRHGLPATGEPGRERFDSRDLFNLALYSGTGRTPVERDVASLLRW
                     TRSSCEDLIAPRVSRFELRVACGDPDGCHPDAHNALARPRTGAYGGAVRHVRAHPGRGG
                     RRVGAAPDAAATTARSSGPAMAISAVLRTVGDCPVLRAPALRAIVREFMGAEPRYLRLP
                     AGLRDDPDLVPRGFAGCGAASRYIERLCREEGVPATTRIGWVVGLPEVVHAWVEVVDDD
                     GVTKVIDPTFTLLAELIPWSNPMLRDPALAFRTNRLVPTGLHVGGDVASHTCGRAPGAA
                     DRPHARVTTRIVPLRPTA"
     misc_feature    complement(18222..18224)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18967..18983)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            complement(18970..20481)
                     /locus_tag="ACTIVE_RS09975"
                     /old_locus_tag="ACTIVE_1993"
     CDS             complement(18970..20481)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852191.1"
                     /locus_tag="ACTIVE_RS09975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1993"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_246342751.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-07, bitscore:
                     30.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDVTGMPGRPSIAIVGSGFSGLGLAIRLIGAGFTDLTVFERGGD
                     VGGVWRENTYPGAACDAPSHLYSYSFELKPDWSRRFAPQPEILGYLRHCARKYGVLEHI
                     RFGCEIASADFDPETGQWNLRTAGGEVHRADLLVAACGQLSVPAVPGIPGLGDFAGTVF
                     HSARWDHGHDLTGRTIAVVGNGASAVQFVPRIAPGAAKLTVFQREPQWVGWKWDRRYPR
                     LRTALNRRIPLLQRLSRLAVFVWFEALLNPMLIAPRGRRVLSAHIRALCRTTLWSVKDR
                     RLRERLVPGYELGCKRVLVSSDYYRALDLPQVDVVTSAVVRATPDGLVTADGREHPADT
                     VIMATGFRTRDFVAPMRVRGLTERDLDEAWRDGPRAYLGMAVAGFPNFFLMYGPNTNVG
                     SGSVVHMLESQISYIVQAARALRDPGVLYMDVREGVLDGFDAALQRRLDGTVWNAGGCD
                     SWYLHSGGGGADGRRRNASNWPGSMLGYRRRTRTLDPSDYRIVMR"
     gene            complement(20598..20879)
                     /locus_tag="ACTIVE_RS09980"
                     /old_locus_tag="ACTIVE_1994"
     CDS             complement(20598..20879)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591568.1"
                     /locus_tag="ACTIVE_RS09980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_1994"
                     /product="sulfurtransferase TusA family protein"
                     /protein_id="WP_173094786.1"
                     /transl_table=11
                     /translation="MGSEAVVIDGGDRSCVRLLLELRGRLADLEPGTVVHLIASDPAAP
                     IDLPAWCHLTGHAYLGPVAADTPTYALRVAERPRATEPDSPWRPAAQG"
     misc_feature    21083..21094
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     misc_feature    21131..21145
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    21317..21331
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
ORIGIN
        1 cgggccggcg cgacgatctc gacggggctg ctgctgaacc tcgaccgcct cgccgccacc
       61 cgcctgtcgt tcttcatggg catccccgcg ctgaccggcg ccggcctgta cgagctgccc
      121 ggcgccctcg gctccggcga gggcgcgctg ccgctcgcgg tcggcaccgc ggtgtcgttc
      181 gtggtcgcct acgcctcgat cgcctggctg ctgcggttcg tcgcgcggca caccttcacc
      241 gcgttcgtgg tgtaccgggt cgcggtcggg ctgctgctgt tcggcctgct cggagccgga
      301 acgctgaacg gctgacgggg acgcggcacg gagcgccagc ggagtgccgt gtccccgtca
      361 gccctgccgt tgccggggag tctgaggggt cgccccctca gatggaacgc tgacgggagc
      421 accggcgggg cggccggtgc ggccggacag gcgtggggca gactggcacg gtccgcacgg
      481 ccggctcgcg gaccgcgcgc ccgaccgtgt ccacatccgc atacggagcg ttgcgcaccc
      541 atgacagacc agatgcaggc cgggaccgtc gcgatcaccg gccacgaggg cgccgagctc
      601 gaggcgtacc tggcccgccc gctcggcgac cggccgcgcg gcggcgtcgt cgtgatccac
      661 cacctgcccg gctacgacga gggcaccaag cagatcaccc gcgcgttcgc cgcccgcggc
      721 tacgccgcga tcctgccgaa cctgtactcg cgggagggca agggggtcag ccccgacgac
      781 caggccgccg ccgcgcgcgc caagggcggc gtcccggacg agcagctcgt cggggacgtc
      841 gcgggcgccg ccgcacacct caactcgctc gaaggggcca acgggaaggt cggcgtgatc
      901 gggtactgct cgggcggccg gcagtcgttc ctcgccgcgg tgtcgctgga cctcgacgcg
      961 gccgtcgact gctacggcgc gttcgtggtg aaggagccgc cggcggactt cccgctgaag
     1021 gcggggccgc tgatcgccaa ggccggcgac ctgtcctgcc cgctgctcgg cctgttcggc
     1081 gaggacgacc agttccccgc gccggacgag gtcgccgagc tggacgcgga gctgaccagg
     1141 ctcggcaagg agcacgagtt ccacagctac ccgggcgccg ggcacgcgtt cttcgccgtc
     1201 gagcgcgcct cctaccggcc cgaggccgcc gtcgacggct ggaagcgcat cttcgacttc
     1261 tacggccggc acctcgcgtc ctgaaaggag acctcgcatg tgcacctacc agacccacaa
     1321 ggtcgagctg gccggggccg ccaagggcgc ggccggctgg ttcacgctga cggacggcgc
     1381 ggtctacgtc gaccacccgt tccactccac gcacgagcac acgctgaaca tcgacttcac
     1441 caacccgtcc gagggaccgt ccgcgcgggt cgcggtggag ctgacggagg aggcggcgct
     1501 cgcgctcgtc gaggccgtcc agaaggccct cgcctccgcg ccgcccggga tggcctccgc
     1561 cgccgggccg cgcggcgcct gacccttcgc gccgcggctt cccgcccggg gacgtatacc
     1621 gaacgtgtac cccgatgcgg gatgatcgcc gaccgggtct gcgcccagcg cggggcgggc
     1681 ccggacgcgc gaggcggaag ggagcgggat ggcgccgctg cttgcggacg accctcggcg
     1741 gatcggcggg tacacggtgg tcgagcggct cggcgccggc ggcatgggga cggtgtacct
     1801 cggccggtcc gcgtccgggc tgccggtggc gatcaaggtg atccacgccg ggcggtccgg
     1861 cgaggcggcc ttccgggccc ggttcgcccg cgaggtgacc gcggcccgcg cggtcggcgg
     1921 cgcgttcacc gcgccggtga tcgacgcgga cccggcggcg gaggacccgt ggctcgtcac
     1981 cgcctacctt ccggggatgt cgctgcagca ggcggtcgcc gagcacgggg cgctgccggt
     2041 gccggcggtg ttcggcctcg gcgcgagcct cgccgaggcg ctggtgtcgg tgcaccgcgc
     2101 cggggtcgtg caccgcgacc tcaagccggc gaacgtgatg ctggcgccgg acggcccgcg
     2161 gctgatcgac ttcggcatcg cgcacgcggc gggcgaggcg gtggtcaccc gcaccgggca
     2221 catggtcggc tcgcccggct acctggcgcc cgagcaggcc gccggtgacg ggacggggcc
     2281 ggccgcggac gtgttcgcgc tcggcgccgt gctggcgttc gcggcgaccg gcgagggccc
     2341 gttcgggcgc ggccgcgcgg aggtgctgat ctaccgggtc gtgcacgatc cgccccggct
     2401 ggacgcggtg cccgacgccg ggctgcgcgc gctgatcgcc gactgcctgg ccaagcgccc
     2461 ggagctgcgg cccgccgcgg cggacctggt gccccggttc gcggcgcggg cgcccgccgt
     2521 cgaggtgctg cagggcacga gctggctgcc cgcgccggtc gccgacggga tcggcgcggc
     2581 ggagcggtcc ctcgcggggc tcggccggga ccggcgggcg ttcctcaagg cgggcgcggc
     2641 ggcgggcgcg gtcgcggtgc tcgccggcgc cgccgccgct ggcacggtgc tggcccgcgg
     2701 gcacggctcg ccgaagaagg cggccgcggg gacgtcgccg tccgccgccc cgacgcccgc
     2761 gacgccgccg gacgccgtgc aggtctggca gcacgacatc ggcaccgacc cgttcggggg
     2821 cctcgccgtg gcggacggga tgctgctcgt cagcgccgat gacggccggc tgatcgcgct
     2881 cgacgcgcgg accggcgagc agaggtggca gcacaagaag tccgggcggg acgggggcgc
     2941 cgcgggctgg cgcacgcccg tcgtgtccgg cggcgtcctg tacgtggggt ggcccgacac
     3001 cgagggaacg ctctacgcct acgacgtgaa gaccggcaag gagaagtggc ggaccgtcct
     3061 gcccggcgac ccgcgcgaac cgggcgccgg cgacgggctc gtcgtcgtcg acgcgggcga
     3121 cctcgtcgcg ctgcgcgcct cggacgggtc ccggcggtgg caccggaaca tcgggaacgt
     3181 ccaggatgtc acgccggccg tcgccggagg ctcggtgttc accgccgacg cgagcacggt
     3241 gtacgcgctc gacgccggcg acgggcgcgt ccggtggcgc caccgcatcg gctcgggcgg
     3301 cgaccagtac gcgcggagca gcccggtggc gtccggcggc atggtgttct gcgggtcggg
     3361 cgacgcgacg ctcgtcgcgc tggacgcggc gtcgggcgcg gagcgctggc acttcctcgg
     3421 cggcacctcg gtcggcgaac ccgccgtcgc cggcggcgtg gtgttcgtcg gggacggcag
     3481 cggcaacatg aacgcgctcg acgcgcggac cggcgccacg cgctggcggc tcgcgaccgg
     3541 cgacgagagc gtcgggcagg cgtccgtcga cggcggggtg ctgtgcttcc tcaccaagaa
     3601 ctggggtttc ggggtggacg ccgcgtccgg gagggcgctg tggaagaccg ccgtgggcgg
     3661 cggcgtccgc gccgacgtgg ccgcggacgg gctgtaccac gtcgggttcg agagcggcca
     3721 gatcatgacg ctcgccgtga aggggacgtg aatggatccg ctgcgcgcgg gcgacccgcc
     3781 gcggatcggc ggcatccggc tgctggcccg gctcgggacg ggcggcatgg ggcgggtgtt
     3841 cctcggccgg acggcggcgg ggcggcccgt cgcggtgaag gtggtgcatc ccgacctcgc
     3901 cggcgacccg gggttccggg cgcggttcgc gcgggaggtc gcggcggcgc gtgcggtcgg
     3961 cggcgcgttc acggcgccgc tgatcgacgc cgacccggac gcgccgcgcc cctggctggt
     4021 cacggcgtac ctgccgggcc ggtcgctgca ggaggcggtg gacgggcacg ggccgctgcc
     4081 gccggcgtcg gtgcgggcgc tcggcgcggg cctggccgag gcgatcgtgg cgatccaccg
     4141 ggccggggtg gcgcaccgcg acctcaagcc gtccaacgtg atgctgaccc cggacggcgc
     4201 ccgcgtcatc gacttcggca tcgcgcgggc ggcggaggcg gcgacggtga cccggaccgg
     4261 caccgccgtc gggtcgcccg gctacatggc gcccgagcag gccgcggggc cgggcgccgg
     4321 gcccgccggg gacgtgttcg cgctcggcgc ggtgctggcg ttcgccgcga ccgggaccgg
     4381 gccgttcggg cgcggcgcgg tgcacgagct ggtctaccgg gtggtccacg agccgccgcg
     4441 gctggacggc gtcgccgacc cggacctgca cgccgcgatc gccggctgcc tggcgaagga
     4501 cccggagctg cggccgtccg ccgcggcggt gctggagcgg ctggcggccc tggcgccggc
     4561 cgcgccgcac ggcgtcgcgt ggctgccgcc gccggtcgcg tccgacatca cccgcccggt
     4621 cccgatgccg gccggcaccc gggacgcggc ggacggcggg cccgcctcgc cggcgcggcg
     4681 gcggccgctc gtcggcggcg ccgccggcgc cgcggcgccg ctggccggcg gcgcggcgct
     4741 caccgccacc gggctgccgg ggggcggcgg cgcggaggcg ggcgcggcgg acggcgtctg
     4801 ggtctacgac ccgaagggga cgttcagcgg cggccccgtc gttctcgggg acctggtctt
     4861 cgcgaccacg ggcatcgggg cggcgacgct gcacgccgtc gaccgccgca cggggcgcaa
     4921 gcgctggtcg gcgggcggtg tgcggtcccc gggcgacctc ttcccgctcg gcgtggcggc
     4981 ctacggcggc gtcgtctacg cgcccggcga cgacgagatc atcgcgctcg accgcgggac
     5041 cggccgcgcg ctgtgggccg cgccgacgcc cggcggctac accttggagg cgcccgtcat
     5101 cggggccggg ctgctgttcg cgccgcagag cgacgcggag tcggtggtgg aggcgtacga
     5161 cggccggacc ggcgcgcggc gctgggtgtt cgacacgggc gggttcgtca ggacgccgct
     5221 gatgaccgac ggctcgctgc tgtacgcgct ggcggagggg accgtgttcg gcgtcgaggc
     5281 ggtgtcgggg cgggtgcggt ggcggcacgg gctcgggcgc cgcgtcgagg tcgtgggcac
     5341 accggcggcg gccggcggcg cgctgtacgt catcgacacg aagagcgtcc tctacgcgct
     5401 ggacgcggcg acgggcaagg cgcggtggac gcagcgcaag ggcgggccgg ggagcgcctc
     5461 cccgcagacc gcggtgagcg tctcgggcgg gaccgtgttc accggagacg gatcccgcac
     5521 cgtgtcggca ttccgggccc gggacggcag gccgctctgg aggcacgcgt tccccggccg
     5581 gaacccggac gggcgcaggc tgctgccgct ggtggcgagc ggggtcgcga tcttctcctt
     5641 cgacgagtcg ctggtcgcgc tggacgcggc gacggggcgg gtgcgctggc aggcgggcgg
     5701 cctgacgggc cccgaccagc ggccggtcct cgcggccggc gcggtgcatc tggccggctg
     5761 ggacgcggtc gtgtcctacg acccggcgac gggccggctg ctgcaccgca ggccccgcac
     5821 caacctggag gccgagaacc tgaccgccgc cggcgatgtc atctactgga cggacgggga
     5881 gggcctgcac gccgcgaagg cgccgcactg acaaccgcca ccgcccgttc cgcagggccg
     5941 tcgccacgct atttcagatt aaaccagtag gaatagttgc atagagagtg gccgacgtgt
     6001 tctgataccg gcatgcgcct ccggccccgc ctcgtccgcc gccgccacgt ggatctgctc
     6061 cgcgtggccg ccgcgcgctg tccggcctga cgacccgccc gcgggcccgc ccccggcggt
     6121 cccgcccgcc cgtcccgtcc ccccaggtcc ggcgccctcc gcgagggcac gagccggccc
     6181 ttcgcccgag gaacacgcgt ttcccatgct cagagaaccc ctgcccagaa acccgcggcc
     6241 cgtccgggcc gcggccgcgg cggccgccgc ggccgcgctc gcgctcaccg ccgccggctg
     6301 cgggacgtcc gcccgcggcg ccaccggcac cgtcaagatc ggctacttcc agggcgccgt
     6361 cgcgggcccc gaggcggtcg tcgcggccga caagggcctg tcggccaagg tgcccggaaa
     6421 gatcgagctg cgcccgatcg acagcggcgt cgccggcatg gcccagctgc gcgccggcgc
     6481 cttccccttc gtcgccggcg tcggcaaccc gcccttcacc ggcgccttca ccagcggaac
     6541 cgacgtcaag gcggtgtacg tcgagggcat cgacgcctcc ggcctcgccg tccacggcac
     6601 catccggacg ccgcgcgacc tgcgcaaggt cggcgtgctc gtcgggtcca cgctggactt
     6661 ccagctgcgc ggctggctga agtcgcaggg cctcgccggc gcggtgcaga tcgccagctt
     6721 cgccagcgag gccgccgagg cggccgcctg gaaggcgggc aagatcgacg ccgtctacat
     6781 cagccagtcc ttcctgctgg agctgcagaa gcacaaggcg cgcgtgctgg tgcggtccac
     6841 cgacatcgcc aagctcggct acgcggcggt caacatgctc gcggtctcca ccccgtacgc
     6901 gcggcagcac ccggaggtgg tgcaggcgct cgtctgccag ctgtccaagg cggaagcgct
     6961 cgtcaagggc ccgcaggccg acaagtacat cgcccccgcc gccaagttcg tcggcgtcgc
     7021 gcccgccgac gcgatcgccg cgacgaagag ctacccgtac atccccgcct ccgaggaggg
     7081 cgcctggctc aagggcccgg acgggacggc cgccaccggg aagctcgccc agaacttcaa
     7141 gctgaccgcc gagttcctcg tcacgcaggg ccgcgcgaag accgtccccg acccggcgcg
     7201 gatcgcgcgg cacatcgatc cgtccttctg ggacaaggcc cagtctggag gctgcaagtg
     7261 agcaccatcg agacccggcc cgcgatcgcc gggcccgccg ccgacggcgg cggcgacgag
     7321 ccggccgggg tgcggttgcg ggacgtccgc aagacgttcg gccggcggcg ccgcccgggc
     7381 cgtcccgcgc tggacggggt gaccctcgac gtgcggccgg gcgagttcct gtgcctgctc
     7441 ggcccgtccg gctgcgggaa gtccacgctg ctgaacatcg tcgccgggtt caccgccgcc
     7501 gactccggcg aggtgctggt cggcggccgg ccggtcaccg ggcccggcca cgaccgcggc
     7561 gttctcttcc agaccccgaa cctgttcccg tggctgacga cctggcagaa cgtcctgtac
     7621 gggccgaagg cgcgcggcgc gctgaccccg cgggtccgcg aggaggccga gcggctgctg
     7681 gagaccgtcg ggctcgccga cgcccgcgac gcctatccgc acgagctgtc cggcgggatg
     7741 cggcaccgcg ccgcgttcgc gcgggtgctg gtcaaccggc cgggcgtgct gctgatggac
     7801 gagccgttcg gcgcgctcga cgccatcacc cgcgccgcga tgcagcggtt cctgctggag
     7861 ctgtggcagg agcaccgcac caccatcgtg ttcgtcacgc acgacgtcga ggaggcggcg
     7921 ctgctcggcg accgcgtgtg cgtgctgtcc gcgccgccgg ccggcaccaa ggacgtcatc
     7981 gacatcgagc tgccgcgccc ccgcgcttac gaggacaccg agacgctcgc gttcgtcaac
     8041 gccaagcgcc gcatccggga ggtgctggag cgatgaccgc gacgaccgaa gcgcccgcgg
     8101 ccaccgccgt ggccggtccc gcgcacggct cgccgcggtc gtggcggcgg gtggggacgg
     8161 gcgccggggc catcgccctc gcactggcgg tctgggaggt cgccgcactc gtcatcggcg
     8221 actccgtcac gctgccgacc gtcaccgaga ccgcccgcac gctcgccgag tacctcggca
     8281 agccgtaccc ggaggtccag ggcaggacgc tcgtcgcgga cgcgctgatc agcaccgggc
     8341 ggatcctcgc cgggttcctg ctcggcaccg ccgccgggct ggcgctcggc gcgtccatgg
     8401 ccgggatccg ggtggtccgg gagctggccg acccgctcat cgcgatcatg cggccgctgc
     8461 cgccgatcgc gttcatcccg ctgctggtgg tctggttcgg catcggcgag acctcgaaga
     8521 tcgcgctgat cttcttcggg gtgctgccga tcgtgaccgt cgcgacgctc ggcgcgctcg
     8581 acgccgtccc gcccgacctg ctgaacgcca gccgcagcct cggcgcgtcc ccactgcgca
     8641 cgatgctgca cgtgcggctg cgcgccgccg tgcccggcgt catcaccggg atgcggatcg
     8701 cgatgggcgg cgcgtggacc gccatcatcg ccgccgagat gatcgccgcc accggcggcg
     8761 tcggctacct catcctgcag gccggcaact acctccagac gccgctgatc ttcagcggga
     8821 tcgccgagat cgccgtgctc ggcttcgcct tcgacggcct gctgcggctg ctgctgcggc
     8881 tcgccgaccc caccgtccgc cgctagaaag ggcacgaacc atgaccgaat tccgccgcat
     8941 cggcggccgc atcggcgccg agtacaccgg gaccgacccc aacgacctgc ccttcgagga
     9001 ggtcaacgac gcgctgctcg cgcacaaggt gctggtgttc cgcggcgccg gcctcgacga
     9061 cgagggccag ctccgcttcg ccgcccggtt cggggagctg acccgggcgc acccgaccgt
     9121 cccgtccgtg gacggccagc cggacatcct cccggtgaac ggcgaggagg gcatccgctc
     9181 caacaactgg cacaccgacg tcaccttcgt ccggacgccg ccgaagctca gcacgctgcg
     9241 cgcgctggtc gtcccgccgt acggcgggaa cacgctcatc gccaactccg ccgccgccta
     9301 ccgcgacctg cccgagcagc tgcgcgactt cgccgaccgg ctgtgggccg tgcacaccaa
     9361 cgactacgac tacgcggtgc cgcgcagcaa caccgagaag gccctcgaat accggaaggt
     9421 gttcaccgcg cgccggtacc ggaccgccca cccggtcgtg cgggtgcatc cggagacggg
     9481 cgagcgcggc ctgttcatcg gcgggttcgc gcaggagatc gtggggctgt ccggcaccga
     9541 gtcgcgcgac atcctgcggc tgctgcagcg gtacgtgacc cgtccggaga acatcgtgcg
     9601 ggtcgcgtgg aaccccggcg acctcgtgct gttcgacaac cgcatcaccc agcactacgc
     9661 gccggacgac tacggcgacc tgccgcgcgt cctgcaccgc gtcaccgtcg ccggcgacgc
     9721 gcccgtgggc gtggacggcg agtccagccg catcctcgaa ggcgacgacg cgggccacta
     9781 cacccccgcc gcggcggcca ccgccgccgc atagcgctcc ccaccggccg gggccgggcg
     9841 gtccgccggg accgtccggc cccgcgacgt tacggcggga tgcacccgaa cggttacatc
     9901 ctgttacccc aaggcaaggt cattgcctgt tgtagtcgcc ctgaagctgt gagtaactgg
     9961 acccggccga ccacgccatg atccagcgag gggaacgacg atggacgagc gcagcgctgc
    10021 ccgcggaccc ggctgcggga cggacgggcc ggcgcgcggg accggggccg gggcccggac
    10081 cgcggacggc gacgcggcgg ccgagcgggt gcgccggctg ctgtccgggc cgaccgggcc
    10141 gggcacgtcg gcggcgcgcc tcctggacgc gctccgcacc gtcccgccgc cgccggagac
    10201 ggctgcgccg cccgcgcccc tcgacggcac cgaggcaccg tccgagcggg aaccggacgc
    10261 cgacgcgccg gaggcgccgg acgcgcaggc ccctcaggac gcacgggacg ctcaggaccc
    10321 ctgtgcggcc gagccggagg ccgccgtccc ggtgctgccg acgccgctgc cgagcccgac
    10381 gcgcaagggc ggccacttct cccccggcta cgccgaacgc gagtggggcg acggctcgta
    10441 cccgccgctg tactgcccgc tgaccgcccg gatcgacgac gacctcgcgc tcgtggtcaa
    10501 cgaccggctc gtcgagtggg ccggcgaggt cgggatctac gccgaccaga tggacaagtt
    10561 ccgcaacacc gggttcgggc ggctcgccgt cctcgcccac cccgaggccg acgacgtcga
    10621 cccgctgctg ctcgccgcca agatgaacgc cgcctggtgg gcgtgcgacg actactacgc
    10681 cgacgagacc gacctcggcg ccgtccccac ccagctgccg ccgcggctcg cgctggtgat
    10741 gtcggcgatg gacccgccgc cggacgcggg caagtacacc gtgcaggtcg aggaggccgt
    10801 ggagtccgac cccgtcctgc gggcgctgcg ctcggccacc gggcacctga agcggcacgc
    10861 cgggccgtca caggtcatgc ggatcctcaa caccacgttc cagatgtacg tgagctggac
    10921 ggcgtacgcg gcgtggcggc acctcggcga gctgcccccg gtgtggcggt acctcgccgc
    10981 ccggcagcac gacagcttct acacctccat gacgctgatc gacgtcgtcg gcggctacca
    11041 gctggacgcg aacctgttct acgagccgcg cgtgcaccgc gcggtgatgc aggcgggcac
    11101 cgcctcggtg atcgtcaacg acctgcactc ggtggagcgg gaggccgccg acgacctgcc
    11161 ggactgcaac gtggtcctgc tgatcgccga ggaggagggc tgcgcgctgg aggacgcggt
    11221 ccgggcggcc gtggcgatgc acaacgactt cgtccgcggg ttcgaggaca gccagcggga
    11281 gctggcctcg ctcccctccg ccgagctgca gcggttcctg ctcggcgtgc agagctggat
    11341 ggccggctgc ctggagtggc acggcgcgtc cgaccgctac aagtgaccgc ccgccccccg
    11401 tcacccgtcc cgccgcgagc gacccgcccc gccccgagtt cccaccccgc cgcaagtgac
    11461 ccacccctgc ccgatgaccc gaaccccacg aaaggatcac cggatatgac cgccacccag
    11521 gactccccgg tcctcggcag cctctaccag cactcggtcg ccgagtactg gaacgccgag
    11581 cgcaacccgg tcaacctccg gctcggcgag gtggacggga tctaccacca ccactacggc
    11641 atcggcgccg tcgactggac cgtcctcgac ggccccgccg agacccgcga gcagcggacc
    11701 atcgccgagc tgcaccggct ggagagcgcc caggccgacc tgctcatgag ccacctcggc
    11761 ccggtcaagc cgtccgaccg gctgatggac gccgggtcgg ggcgcggcgg gtcgagcctg
    11821 gtcgccaacg agcggttcgg ctgccgggtc gacggggtgt cgatctcgga gtcgcaggtc
    11881 gcgttcgcca acgaccaggc cgagcggcgc ggcgtcgcgg acaaggtccg cttccacttc
    11941 aagaacatgc tcgacaccgg cttcgagacc ggggcgttcc aggcgatctg gaacaacgag
    12001 agcaccatgt acgtggagct gggcctgctg ttcgccgagc acgcccggct actgcggcgc
    12061 ggcggccggt acgtgaccat caccggctgc tacaacgacg cctacgggct gccgtcgcgg
    12121 gccgtcagcg agatcaacgc gcactacatc tgcgacatcc acccgcgcag cacgtacttc
    12181 cgggagatgg cggcgaaccg gctggtgccg gtgagcgtcg tggacctcac gtccgcgacg
    12241 atcccgtact gggagctgcg cgcgaagtcg acgctggcga ccggcatcga gcaggcgttc
    12301 ctggacgcct acaagggcgg cagcttccag tacctgctga tcgccgccga ccggatctga
    12361 gtccggcctg agcaaggggg gaacgccgcg gcccgccggt gggagcaccg gcgggccgcg
    12421 gggtcctcag cggggcggtc cgggcgggcg tcagctcgcc aggaaggtgc gtacggcgtt
    12481 cagcaccgtc gtgtcggtga ggtaggtgag gtggttctcg caggccacgt agttgttggt
    12541 ggcgccgctg agcatggtgc tggtgtaggg gttgatgacg ccgtcgcagg gcgagtacca
    12601 ggtggcgtac ttggtgtcgc cgggcgtctc atcaccggag gcgagcgtct ggatgaacga
    12661 cgagccgggc gacatctgct ggcaggtcgt gtagatcagg caggcgtagg cggcggtggt
    12721 gccgtggttg gcgccggcga gggacgccag gtgcctgacg tactgctggc cgccgagctc
    12781 cttgatgtac caccagctga cgagcccgcc catcgagtgg ttcacgatgt cgaccttgga
    12841 cgcgccggtc tgcgcgcgca cctggttcac gtaggaggcg aggctggcgg cgttggtctt
    12901 gttgtcgccg taggagttgt agttgaacgc gaacatctcg ttgctgctgt agccggccgc
    12961 ggcgaacacc gcctccgcgg tgacccagtt ggacgcgttg ccggtgtagc cgtggacgaa
    13021 gaccacgggc gtgtgcccgg ccgcctgcgc gggcgcgctc acgccgacga cggcaccgag
    13081 cacggtgacc gccgcggcca ggagagtgcc gagaatccgg cgcatctgct cctcctcggg
    13141 gggtgggggt ttcgtcaccg agtgtcggtg ccgccgccgg tccccgcatc ggcgaaatcg
    13201 ccggtctcgc gtgtccggtg cgtgctggcg ccggaacgtc ccgtggagcc gcgggagcgg
    13261 gcggccgtcg gccgttccgg ccgtcagccc tgatcgcggc gggcgcgggc gcggcgcttg
    13321 ccctcgtgca tcgcctggac gcgggcgatg gggatggtgt ggccctccgc gacgaggtcg
    13381 gcgggcaggg ggcgcgctgc gggcatcaac tccgcccaaa ggtcgcggtc ggcgagcagc
    13441 cgcgccgccg tccggacggt gaaggcgcgc gggtcggcgg cgtcgagccc gtcccacggg
    13501 acggggaacg acaccggggt gccgggcctg atccgggggc tgtaggcggc ggcgacggtc
    13561 gcgccgcccg cccgggtcga gtcgaggaac accttgccgg cgcggtcctc gcggatgaac
    13621 gccgtggtgg cgagggccgg gtcgagccgt tcggcgcggg cggcgagcgc gcgggtcgcc
    13681 gccgcggcgt cgtcggcggc cgtgcggccg tcgagcggca cgaccacgtg gacgcccttg
    13741 gacccgctgg tcttcaccgc gccgtcgagc ccgcagtcgc cgagcgcgcg gcgcaccagg
    13801 tgcgcggcgc cggccgcggc ggcgaacggg gcgccctccg gcgggtcgat gtcgatcacc
    13861 aggtgggtgg ggaggccggg gtcggcggcg aggacgagcg gcgggtggta ctccaccgcg
    13921 cgctggttgg cgaaccacag cagggtgcgg cggtcgtcgc acagcgcgta ggacacgtcg
    13981 cgctgcgacg tctcggccca caccgtgacc cgccgcaccc agggcggcgt gtacttgggc
    14041 aggttcttct gcatgaacgg cttctggccc cgcagcacgc ggacgaccga cagcgggcgg
    14101 cccgccagcc gcgggacgag ccggccggcg acggcgtcga ggtagtcgac cagatcgcgc
    14161 ttggtggcct cggcgccggc gaacagcggc tggtcgaggt tggtcagccg gaccccgtcc
    14221 cgctcctctt cggtgctcac acccccacct tcgcacgccc ctccgacagg ccggtcgggt
    14281 agcgtcggag cgtgtacata cccgcacatt tctcggccgg tgacgcggag gtccgcgcgc
    14341 tgctggacgg ctgcggcgcg gccgacctcg tcacgagcac gccgcgcggc ctcgtcgcga
    14401 cgttcctgcc cgtcctgtac gacccggacg ccggcgagca cggcgcgctg ctcgcgcacg
    14461 tcgcccgcaa caacgaccag tggaaggagc ccgcgcaggg cgagtccctg gtcgtcgtgc
    14521 acgggcccga cgcgtacgtg acgccgtcgt ggtacgcgtc caaggccgag cacgggcggg
    14581 tcgtgcctac ctggaactac ctcaccgcgc acgtctacgg gcggctggtc gtgcacgacg
    14641 acccggcgtg gctggagtcg ctggtgcggc ggctcaccga caagcacgag gcgggccggc
    14701 cggacgcctg gtcggtggac gacgcgccgc cggagtacat cgccgggcag ctgcgcgcga
    14761 tcgtcggcct ggagctggtc atcacccgga tcgaggcgaa ggcgaagctg agccagaacc
    14821 ggccgggggc cgaccgggac ggcgtcgccg ccggatacct cgccgacggc gaccccgcca
    14881 tggccgaggc cgtgcgcgcg gcggccgggc gcgccgcggc cgggccggag gcgccgggac
    14941 ggtgaacgcc cgcacggtca gcccggtgct cgtcgggcgc gagcgcgagt ccgccgcgct
    15001 cgacgccgcc ttccgcgccg cccgcgacgg caccccgtcg gcggtgctgc tcggcggcga
    15061 ggccggggtc ggcaagaccc ggctggtggc cgagttcggc gcccgcgccc gcgccgaggg
    15121 cgcgcgggtg ctggtcggcg gctgcctgga gctcggcacc gaggggctgc cgttcgcgcc
    15181 gttcaccgcg gcgctgcgcg ggctcgtccg cgacgtcggc gtggacgggg tgcgcggcct
    15241 gctgcccgcg ggcgcgggcg acgggctggg ccggctgctg cccgacttcg gcgacgcgga
    15301 cgcgggcgcg ttcaccgccg agtcgcgggc ccggctgttc gagctggtgc tgacgctgct
    15361 ggagcggctc gccgcgtccg ggccggtggt gctggtcgtc gaggacgcgc actgggcgga
    15421 cgcctcgacc cgcgacctgt tgacgttcct cgtccgcaac ctcggcgcgg gcgacgcgct
    15481 gctggtcgtc gccacgtacc ggaccgacga gctgcaccgc acccatccgc tgcgccccgt
    15541 cctcaccgag ctggagcgcg tcgagcacgt cgcccgggtc gaggtcgggc ggctcggccg
    15601 ggacgaggtc ggcgagctgg tgcgcggcat cctcggcgcg gacccgccgg ccggcacgct
    15661 cacggaggtg ttcgggcgca gcgagggcaa cccgctgttc gtcgaggcgc tcgtcggctc
    15721 gggggcgggg cacgacctgc cggagtcgct gcgcgacctg ctgctcggcg ccgtccagcg
    15781 gctgccggag gacacccagg agatcctgcg ggtcgcggcg ggcggcggcg cgcggatcga
    15841 gcacgagctg ctcgcggcgg tcgcggggct ggacgagcgg gagctgaccc gcgggctgcg
    15901 gcccgccgtg gcggccaaca cgctggtggt ggacggcgac ggctacgcgt tccggcacgc
    15961 gctgatccgc gaggccgtgc acgacgacct gctgcccggg gagcggacgc ggctgcatgt
    16021 ccggtacgcg cgggtgctgg aggagcgtcc ggagctgatg ccggaccggg cgcgggcggt
    16081 gacgctggcg taccactggc acgccgcgca cgacgtcgtc cgggcgctga cgtcggcgtg
    16141 gctggccgtc ggggagaccc ggcgggcgct cgcctacgcc gaggcgctgc ggatggcgtc
    16201 gcgggtgctc gggctgtggg agcgggtgcc ggacgcggcg gagcggatcg gcgtcccgca
    16261 cgtccaggtg ctggaggagg ccgtcgagct ggccgacctc gcgggcgagc cggacaccgg
    16321 ggtccggctg gcgacggagg ctctgcggca cgtggacgcg tcggccgagc cggtgcgggc
    16381 ggcccggttc tacgagctgc gcggcatgat gcggctgcgg gcgggcagcg acaaggctcc
    16441 cgcggacctg cgcgaggcgg cgcggctggt gcccgcggac ccgccgtcgg cggcgcgcgc
    16501 ccgggtgctc gccacgctcg ccacgcggat cacgggcctg cacggcacgc tcggggaggc
    16561 gctcgacacc gcgcgcgagg cgctggaggt cgcgcgggcc gtcggggacg ccgaggccgg
    16621 gctgtcggtg gagctgaacc tcgcctggct cgacctgttc gaccaggacg acccggaggc
    16681 gttcatcgcg cggatcgggc ggatcggcga gcaggcggcg cgggcggggg cgttcgagcc
    16741 gctgctgcgc gcgatcacca accattccga cgtgctggag atgtacgggc ggcacgagga
    16801 ggccgcgaag gtggccgccg agggcgtggc gcgggccgag gagcacgggc tggcccgctc
    16861 cgccggggca ttcctgtcga tcaacgcggc ggagccgctg atgttgctcg gccggtggga
    16921 cgaggcgctc ggcgtggtcg gccggacgct gccgcggacg tcggccggcg tgatccgggc
    16981 cgggctgcac aacctggcgg ggacgatcgc gctggcccgc ggcgacctcg ccgccgccga
    17041 ccggcacgcc gcggagacgc cggggctgat cgcgcgcggt gcggcgcgcc gcacgcagaa
    17101 cctgttcccg gtgtgccggc tgctcgcgct catcgcgctg gcgcacgggc gcccggccga
    17161 ggccttggac gcgctggagc cgatcctcac cgacgtgggg ctgccggacg actcccggta
    17221 cgcgttcccg gggctggtgg tggcggccac cgcgtgcgcg gagctcggcg acaccggcgc
    17281 gctggcggcg gcgcggaccc gtgtcgaggg gctgcgcgtc tacgggccgg tccaggaggc
    17341 gcaccggctg acgttcaccg ccgaggccgc gcgcgccgaa ggcgtcctgg acgaggcggc
    17401 gtgggacgcg gcggccgcgg cgtgggacgc gctgcaccag ccctacgaga cggcgtcggc
    17461 gctggtcagg gtcggtgagg ccaggctcgc cggcgggcac cgggaccggg cgggcgcggc
    17521 gctgcggcgg gccgccgacc tcgcggccgg gctgggcgcc gagccgctgc gggacnnnnn
    17581 nnnnnnnnnn nnnnnnnnnn ctgcgggacc gcgccgccga cctcgcgcgc cgcgcgggga
    17641 cgccggccgg cggcgagcgc cccgccccgg gcctcggcct cacgccgcgc gagaccgagg
    17701 tgctgcggct cgtcgccgcc gggcgcagca accgggagat cgccgaggcg ctgttcatct
    17761 cggtgaagac cgcgagcgtg cacgtgtcca acatcctcgg caagctcggc gtcgccgggc
    17821 gcggcgaggc cgccgcgcgc gcccaccggc tgcggctctt cgactagcgg cggtgcctgc
    17881 ggttcaggcg gtcaggcggt cgggcggagc gggacgatcc gggtggtgac gcgggcgtgc
    17941 gggcggtcgg cggcgcccgg cgcccggccg caggtgtgcg acgcgacgtc cccgccgacg
    18001 tgcaggcccg tcgggacgag ccggttcgtg cggaacgcga gggcgggatc gcgcagcatc
    18061 gggttcgacc aggggatcag ctccgcgagc agcgtgaacg tcgggtcgat caccttggtg
    18121 acgccgtcgt cgtccaccac ctcgacccag gcgtgcacga cctcgggcag cccgacgacc
    18181 cagccgatcc gggtcgtcgc gggcacgccc tcctcccggc ataaccgctc gatgtagcgg
    18241 ctggcggcgc cgcagccggc gaagccgcgg ggcaccaggt ccgggtcgtc gcgcaggccg
    18301 gcgggcaggc ggaggtagcg cggctcggcg cccatgaact cgcggacgat cgcgcgcagc
    18361 gcgggggcgc gcagcaccgg gcagtcgccg accgtccgca gcaccgccga gatcgccatc
    18421 gcgggaccgg acgaccgcgc ggtcgtcgcg gccgcgtccg gcgccgcgcc cacccggcgg
    18481 ccgccgcgcc ccggatgcgc ccggacgtgc cggaccgcgc cgccgtaggc gccggtgcgg
    18541 ggccgggcga gggcgttgtg ggcgtcgggg tggcagccgt cggggtcgcc gcaggcgacg
    18601 cggagctcga accgggacac gcgcggcgcg atgaggtcct cgcacgacga gcgggtccag
    18661 cgcagcagcg acgcgacgtc ccgctcgacc ggcgtgcgtc cggtgccgga gtacagggcg
    18721 aggttgaaca ggtcgcgcga gtcgaaccgc tcccggccgg gctcgccggt ggccggcagg
    18781 ccgtgccgga cgagcgcggt cagcgtccgg tcgtcgcagg cgagcaaccg cgcggcctcg
    18841 gcgcgtccgg tgtcgggccg gtggtggccg ggcgggatga cgtagaggct ttcgagcgcg
    18901 cccagcagcc ggcggtcggc gccgtcgcgg gcacggttcc gggtcgtggt ccggtgtgcg
    18961 gcggccatgt cagcgcatca cgatccggta gtcggacgga tcgagggtgc gggtgcggcg
    19021 ccggtagccc agcatcgagc cgggccagtt gctggcgttg cggcggcgtc catccgcgcc
    19081 gccgccgccg gagtgcaggt accagctgtc gcagccgccg gcgttccaga ccgtcccgtc
    19141 gaggcggcgc tggagcgcgg cgtcgaagcc gtcgagcacc ccttcgcgga cgtccatgta
    19201 gagcactccg ggatcgcgca gcgcgcgggc cgcctgcacg atgtaggaga tctggctttc
    19261 gagcatgtgc accaccgacc ctgagccgac attggtgttg ggcccgtaca tcaggaagaa
    19321 gttcgggaag cccgcgacgg ccatccccag gtaggctcgc ggtccgtccc gccacgcctc
    19381 gtccaggtcc cgctcagtga gacctctgac gcgcatgggg gcgacgaagt cgcgggtgcg
    19441 gaagccggtg gccatgatga ccgtgtcggc ggggtgctcg cgcccgtcgg cggtgacgag
    19501 gccgtccgga gtggcccgga cgacggcgct ggtgacgacg tccacctgcg ggaggtcgag
    19561 ggcgcggtag tagtcgctgg agaccaggac gcgcttgcag cccagttcgt agccggggac
    19621 gaggcgctcg cgcagccgcc ggtccttcac cgaccacagc gtcgtgcggc agagcgcgcg
    19681 gatgtgcgcc gacagcaccc ggcggccgcg cggtgcgatc agcatcgggt tcagcagcgc
    19741 ctcgaaccag acgaacaccg cgaggcgcga cagccgctgc agcagcggga tccgccggtt
    19801 gagcgcggtg cgcagccgcg ggtagcggcg gtcccacttc cagccgaccc actgcggctc
    19861 gcgctggaag acggtcagct tcgccgcgcc cggcgcgatg cgcggcacga actgcaccgc
    19921 gctcgcgccg ttgccgacga cggcgatggt ccgtccggtg aggtcgtggc cgtggtccca
    19981 gcgcgcggag tggaacacgg tgccggcgaa gtcgccgagc ccggggatgc cggggaccgc
    20041 cgggacgctg agctgcccgc acgcggcgac gagcaggtcg gcgcggtgca cctctccccc
    20101 ggccgtccgc aggttccact gcccggtctc cgggtcgaag tcggcggacg cgatctcgca
    20161 gccgaaccgg atgtgctcca ggacgccgta cttgcgggcg cagtgccgca ggtagccgag
    20221 gatctcgggt tgcggggcga accggcgcga ccagtccggc ttcagctcga acgagtagga
    20281 gtacaggtgg gacggggcgt cgcaggcggc ccccggatag gtgttctccc gccagacgcc
    20341 gccgacgtcg ccgccccgct cgaacaccgt caggtcggtg aagccggcgc cgatcagccg
    20401 gatggcgagc ccgagcccgc tgaacccgct gcccacgatc gcgatcgacg gccgtcccgg
    20461 catgcccgtc acatccctca ctcaattggc gctacgccaa tagtgacgga cgaggcgtca
    20521 aaaggaaacg gcccggccgc cggaaggcgg gcctccggaa ggcgggcctc cggaaggcgg
    20581 gccgccggcg gacgggctca gccctgcgcc gcgggacgcc agggggaatc gggctcggtg
    20641 gcgcgcgggc gctccgccac gcgcagcgcg taggtcgggg tgtcggcggc gaccgggccg
    20701 aggtaggcat gccccgtcag atggcaccac gcgggcaggt cgatcggcgc cgccgggtca
    20761 ctggcgatca gatggacgac cgtgccgggc tccaggtccg cgaggcgccc gcgcaattcc
    20821 agcagcaggc gcacgcagga acggtccccg ccgtcgatga ccaccgcttc cgaacccatc
    20881 cggcctcccc cgccgcccgt ccttgtgacg accaatcacc tcatggggga aatatagggc
    20941 tttagggtct gcgcttcacc gaggaacatc ccgcggcagg cgatcattac aagatgccgg
    21001 gagcatgcac cgcaccgcgg tggacgatcc cgcgtccggg gccgggcccg cgcgcatccg
    21061 aagcgacgaa cacggagcaa tcggaagcga acgcgatgat cgacaatatg agggagcagc
    21121 gccccactct tgaccctctc tttcaggttt cgtccagctt tggggcttac agtcgcagtg
    21181 aagcaccccc agaagtcacc cacgtgagga acctgacctt ggggcgagcc atggaactcg
    21241 gagcagcgcg agtggagagc acggagacct gcgggacgct gtccttcccc gccgaggtcg
    21301 acctgagcaa cggcgaggag atcctcggcc aggccctcgg gctgctcgac tccggggcgc
    21361 ccgccctcat cctcgacctc tccggc
//
