LOCUS       NZ_CP053564            22075 bp    DNA     circular CON 29-MAR-2024
DEFINITION  Pseudonocardia broussonetiae strain Gen 01 chromosome, complete
            genome.
ACCESSION   NZ_CP053564
VERSION     NZ_CP053564.1
KEYWORDS    RefSeq.
SOURCE      Pseudonocardia broussonetiae
  ORGANISM  Pseudonocardia broussonetiae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Pseudonocardia.
REFERENCE   1  (bases 1 to 7177725)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-MAY-2020) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013155125.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:16:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,087
            CDSs (total)                      :: 7,032
            Genes (coding)                    :: 6,962
            CDSs (with protein)               :: 6,962
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 70
            CDSs (without protein)            :: 70
            Pseudo Genes (ambiguous residues) :: 0 of 70
            Pseudo Genes (frameshifted)       :: 19 of 70
            Pseudo Genes (incomplete)         :: 48 of 70
            Pseudo Genes (internal stop)      :: 6 of 70
            Pseudo Genes (multiple problems)  :: 3 of 70
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:38:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5764152
            Orig. end                         :: 5786227
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053564.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22075
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="13"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22075
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22075
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12075](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12075
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    1031..1046
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.88"
                     /tool="antismash"
     gene            1131..2579
                     /locus_tag="HOP40_RS27910"
                     /old_locus_tag="HOP40_27925"
     CDS             1131..2579
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020932.4"
                     /locus_tag="HOP40_RS27910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27925"
                     /product="EfeM/EfeO family lipoprotein"
                     /protein_id="WP_172164159.1"
                     /transl_table=11
                     /translation="MRDQRRDDPESTTSFVAGRPKIDTATDKMPARREGPVPPVPPARR
                     APRAGRPVVPPPAAPVDATVAGPLVPGAPSVPVVPVVTAAAALTAAVPQVVAAPAPVSP
                     VPLARPGGPGGRPPAPRTGTGPVGRPLRPEPLRPEGLRPEPVRPEPLRPEPVRAASLPE
                     PPVRRPAPEIPSQRTRPPAPAPRRRRRRLQPVVLAAAAVAAAGGVTWGVLSVGAPDREP
                     APVFGVPVVFQHATALDEAGARYRDFVVAEADALRESTADLVAAVRAGRVAVAQDRYPA
                     ARTHWERIQVATEAVTGPDGEELGPAIDGQGVGMDPGETFTGFHRLERDLWVDGLQPDT
                     RQVADDLLADVTALAQGAVALELGGPDLCGSAKELVDFAVVTTLSGRENRFAGTDMSDL
                     AARVEGSEAAVEALRPLLTDVDPALLTELDRRFAETYAVLDRYRTGGGFRPYTDMTAAD
                     LKAVADVLDALGEPVSHVGGAVLV"
     gene            2579..3847
                     /gene="efeB"
                     /locus_tag="HOP40_RS27915"
                     /old_locus_tag="HOP40_27930"
     CDS             2579..3847
                     /EC_number="4.98.1.1"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0033212 - iron import into cell [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="efeB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010697083.1"
                     /locus_tag="HOP40_RS27915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27930"
                     /product="iron uptake transporter
                     deferrochelatase/peroxidase subunit"
                     /protein_id="WP_172164162.1"
                     /transl_table=11
                     /translation="MPRMNRRTLFGIAGAGAAAAAGAGAVLAAEHVLPASVGGGPDDVV
                     PFRGARQAGITTAAQDHLYFVALDVTTTDRAELVDLLQRWTLAAERLTTGAEVAVDGAI
                     GGHPEAPPQDTGEALGLPPARLTLTFGVGPSLFTRDGVDRFGIADRRPPKLIDLPLFAG
                     DAIEPGRSNGDLCIQACADDPQVAVHAVRNLIRMGFGTTAVRWAQMGYGRTSSTVVGQA
                     TPRNMFGFKDGTSNITAEDTAGLARHVWAAAEDGADWMTGGSYLVARRIRMAIEPWDRT
                     SLLEQEEIVGRHKGSGAALGATDEFAEVDFSATRPDGSGPLVGMDSHVRLAHSSTLGGV
                     RILRRGYNFIDGTDAEGHLDAGLFFIAFVRDPGAQFVPMQQALSTKDIMMEYLVHTSSA
                     LFACPPGVGTGDHWGRTLFGNPA"
     gene            3920..4351
                     /locus_tag="HOP40_RS27920"
                     /old_locus_tag="HOP40_27935"
     CDS             3920..4351
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419101.1"
                     /locus_tag="HOP40_RS27920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27935"
                     /product="DUF1232 domain-containing protein"
                     /protein_id="WP_240157314.1"
                     /transl_table=11
                     /translation="MDVDWAAWLTGLGIAAAVWGVLCVVMVLLASRLPPGLLRDIAEFL
                     PACVTTARRLRRSPAVPRRAKVALLVAIIWVVSPIDLLPEFLPVIGPLDDVVAVVLLLR
                     YAARSIPRDQLVAAWPAELRLLERLLDGRRRPDRDPEPR"
     gene            4414..4623
                     /gene="rd"
                     /locus_tag="HOP40_RS27925"
                     /old_locus_tag="HOP40_27940"
     CDS             4414..4623
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0072592 - oxygen metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018334408.1"
                     /locus_tag="HOP40_RS27925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27940"
                     /product="rubredoxin"
                     /protein_id="WP_338053038.1"
                     /transl_table=11
                     /translation="MDQGTLQASPTRWICEPCGFVYDPAEGDPDSGIEPGTPFEDIPDD
                     WMCPICGATKADFRELEPGEFPED"
     gene            4635..5396
                     /locus_tag="HOP40_RS27930"
                     /old_locus_tag="HOP40_27945"
     CDS             4635..5396
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018334407.1"
                     /locus_tag="HOP40_RS27930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27945"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_172164168.1"
                     /transl_table=11
                     /translation="MITGYAHFAQLAESLQWDEKAIDFSADREAWPRLTGAENARVLGL
                     VAGFVIAETSVSGQLGAYEAAAPDESMAAVFQAQARDEARHARFFDRVSAEVACVPGEL
                     PAQRRDALRAHVGDELVDLFEHRLPATARRLAEDHAGLTAAVGLYHMVIEGVVLLAGQH
                     AMLDALEGLSVGLPGVRKGMELVLRDERWHIGFGSRVVQSAAIGREEADALLEQGETAA
                     KVWGDLITTEAIETAVRQHRRRLKAAGIKFW"
     gene            complement(5383..6150)
                     /locus_tag="HOP40_RS27935"
                     /old_locus_tag="HOP40_27950"
     CDS             complement(5383..6150)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HOP40_RS27935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HOP40_27950"
                     /product="hypothetical protein"
                     /protein_id="WP_172164170.1"
                     /transl_table=11
                     /translation="MRRFGSPEALARLSARCAHADSVELKALLVPPAGPAAEALTGRCA
                     PTWSVRQTYLLDTPALDLLEAGVEVRLRRRARGRFDLSVSTCRSGDARRRAFPRGVRVE
                     VDVVPGALWQDVEVRREVDAAAAADVIAGAARSRELLTADQSAWARRAAHGCVDEGHLR
                     RLGVHGPLVVRRVKVGADRLGLHRADLEHFRYPSGRELLELSTRCWPREVLATATAFEQ
                     LLDERDVVVAAGHRTKASMWRDEIGQRAAVTRT"
     gene            6696..7154
                     /locus_tag="HOP40_RS27940"
                     /old_locus_tag="HOP40_27955"
     CDS             6696..7154
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:1901661 - quinone metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018334411.1"
                     /locus_tag="HOP40_RS27940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27955"
                     /product="MSMEG_3727 family PQQ-associated protein"
                     /protein_id="WP_172164173.1"
                     /transl_table=11
                     /translation="MTTTDDPSGKLADGLHRQNATGLGRLLGSGGVGHAEEGPDGTMTA
                     TVRIPEDELCFEPGTLILPHGGNLELTLINDDKNTHCAVLPHNGDPKIIWLVNHSKGTA
                     SLNLDGPGTYYYGSTTGNDEGRGLTGAIVIGGEVPDHAKLDRPPQPRP"
     gene            7170..8858
                     /locus_tag="HOP40_RS27945"
                     /old_locus_tag="HOP40_27960"
     CDS             7170..8858
                     /EC_number="1.1.2.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241631.1"
                     /locus_tag="HOP40_RS27945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27960"
                     /product="PQQ-dependent dehydrogenase, methanol/ethanol
                     family"
                     /protein_id="WP_172164176.1"
                     /transl_table=11
                     /translation="MTDYVDAGAAIPQMQLSAIKGSAPATGNVDHDRILRARTEPENWL
                     TYYGTFDGQRYSELDQISKDNVRRLSPAWVFQAGSTGMQAGASTYSFEACPIVVEGVMY
                     VSGPDGRCWALDAKTGAELWRYKHASPYDVSLCCGNVNRGVAVGHGKVYMATLNAHVIA
                     LDATTGEKVWDTTAGDVRAGESRTVAPLLVKDMVIVGSSGGEFGTRGCLDAFDADTGER
                     RWRRYMIPKPGEPGSETWPDDGEAWQRGGANCWVTPTYDPELELLFPGTGNPAPDFDGG
                     VRPGDNLYTDSVVAVDVNTGEIRWHYQFTPHDLWDYDSTMENLLFDAPDGRKLMAHADK
                     NGYFFVLDRTNGELVRVFPFVDRITWGEISPDGKVTPKLYPDEEGVPVHFWPGPAGGKE
                     WTHMSYSPQTGLVYIPVQEVGATATRRRREFKESIPYWGAGVAVDLEDFYGFVSAVDPL
                     TGEEKWRWRYEYPMTASTLVTAGGLVFVGLATGEFIALDAATGEKLWQFQCGSGHHSSP
                     STYSIDGRQYVAVPTGFGGWVEGFTPGLLGAASGDSLFVFALPED"
     gene            8900..8992
                     /gene="pqqA"
                     /locus_tag="HOP40_RS27950"
                     /old_locus_tag="HOP40_27965"
     CDS             8900..8992
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672938.1"
                     /locus_tag="HOP40_RS27950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27965"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_172164179.1"
                     /transl_table=11
                     /translation="MERLAEWEAPDFDEVGCAPEVTMYIARSED"
     gene            9093..9992
                     /gene="pqqB"
                     /locus_tag="HOP40_RS27955"
                     /old_locus_tag="HOP40_27970"
     CDS             9093..9992
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241627.1"
                     /locus_tag="HOP40_RS27955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27970"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_172164182.1"
                     /transl_table=11
                     /translation="MRVRVLGSAAGGGYPQWNCSCPTCRAVREGTRPARARTQSSIAVS
                     PDGERWFLVNASPDVRAQVEAFPRLHPGAGRATPLEAVLLTDAELDHTLGLLLLREGRG
                     IELHATAATHATLTAGTGVLTTLERYCPVGWTPVVPGKEVSLGGISYQAFDAPTGKHDR
                     FGGGTGEGRVVGYRFTDEATGAAAVYLPGVQELTPAVLAELEGVDCLLVDGTCWHDDEM
                     IRLGLAAKTAHGMGHLAVGGPGGSLEQLAGLPIARRIYVHINNTNPMLLEDSPERRHVE
                     RCGMEVAHDGLEVEVPAR"
     gene            10001..10729
                     /gene="pqqC"
                     /locus_tag="HOP40_RS27960"
                     /old_locus_tag="HOP40_27975"
     CDS             10001..10729
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696862.1"
                     /locus_tag="HOP40_RS27960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27975"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_172164185.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.4e-95, bitscore:
                     317.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTDAMTTGAPPEVDALVERLRAHSQSYHSAHPFHLRMNEGLLA
                     PAQIRGWVANRYYYQEMIPRKDAAILANCPDPAVRRRWIRRITDHDGTADGEGGIEAWL
                     RLGEACGLRREEIADHRHLVPGVRFAVDAYVTFARTRPWVEAVASSLTELFAPDLMAER
                     LRAFEQRYTWIAPEGLAYFRNRLEQAPRDSEHALEVVLRYCRTLQDQDAAVAALSFKCD
                     VLWSMMDAIDQAYGDRSRAG"
     gene            10719..11000
                     /gene="pqqD"
                     /locus_tag="HOP40_RS27965"
                     /old_locus_tag="HOP40_27980"
     CDS             10719..11000
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011874340.1"
                     /locus_tag="HOP40_RS27965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27980"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_240157315.1"
                     /sec_met_domain="PqqD_RRE (E-value: 7.1e-23, bitscore:
                     78.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-13, bitscore: 49.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGDVPPSGRPALARHVRMRFDPTRERHVLLGPESVIVLNPTGAD
                     ILGLCDGRRTVSDVAAALRVRYERVVDDEVTAFLARLVTKRCVEISDG"
     aSDomain        10740..10985
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HOP40_RS27965_PqqD_RRE.1"
                     /evalue="2.90E-25"
                     /identifier="RREFam006.1"
                     /label="HOP40_RS27965"
                     /locus_tag="HOP40_RS27965"
                     /protein_end="89"
                     /protein_start="7"
                     /score="78.8"
                     /tool="antismash"
                     /translation="SGRPALARHVRMRFDPTRERHVLLGPESVIVLNPTGADILGLCDG
                     RRTVSDVAAALRVRYERVVDDEVTAFLARLVTKRCVE"
     gene            10993..12075
                     /gene="pqqE"
                     /locus_tag="HOP40_RS27970"
                     /old_locus_tag="HOP40_27985"
     CDS             10993..12075
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672942.1"
                     /locus_tag="HOP40_RS27970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27985"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_172164188.1"
                     /sec_met_domain="PTHR43273 (E-value: 6.4e-30, bitscore:
                     103.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.6e-24, bitscore: 85.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-07, bitscore:
                     30.7, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.9e-07, bitscore: 29.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRPFGLLAELTYRCPLACAYCSNPLELAAYDDELGTAEWQRVFT
                     EAAAMGVLQCHLSGGEPLLRRDLVELVRTAADLGMYTNLVTSAIGLSRGRAEELKEAGL
                     DHVQVSVQADEPATSDRIAGIPSFERKLRAAAVVKELGWPLTVNVVVHRQNIDRLAEII
                     ALVEELDADRVELANTQYYGWAWRNRAALLPSRAQLAAAEDVVRAARERLAGRMEVLHV
                     LADYYSAYPKPCMGGWAARQLTVAPNGDALPCPAAQTLPLPRASVREESLQRIWDDAPV
                     FTAFRGTGWMSDPCRTCDRREIDFGGCRCQAFQLTGDAARTDPVCHLSPDHALVADAVE
                     AANAGGRRHEEVLVPRPHRA"
     gene            complement(12098..13162)
                     /locus_tag="HOP40_RS27975"
                     /old_locus_tag="HOP40_27990"
     CDS             complement(12098..13162)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942743.1"
                     /locus_tag="HOP40_RS27975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27990"
                     /product="sodium:proton exchanger"
                     /protein_id="WP_172164191.1"
                     /transl_table=11
                     /translation="MTSVFVFISGATLLVFSAEKLIGYLVGAASGLRVSLFLLAIVFTG
                     IEFDDIFLGVALNLEDLSGVALGTVFGTAISLTGVVLAIAAILTPVRLQIPRDYVALLA
                     GAPLVMIVFTLTAPLTLVDGVVLVALFVLFITYVAVRESQRAIPVFRNAEIYAGMVETG
                     GGREDRAEGDPAEGEQAPGTSFADEMPFAEARRLPGWAGLALALLALTGLVVGAATTGI
                     GVEGILEAYGIEGTLFGATIVTAVLTLEDVFLTVEPIRRGAPEVGIGNVIGSVVFSVTG
                     KLGVIILAGGAIVVGPDVLTWHLTALIAVTGLAAYFLWTGRLQRWHGFVLLALYVAYWV
                     LSFVVLGGPPIEVD"
     gene            13353..13727
                     /locus_tag="HOP40_RS27980"
                     /old_locus_tag="HOP40_27995"
     CDS             13353..13727
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222011.1"
                     /locus_tag="HOP40_RS27980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_27995"
                     /product="FKBP-type peptidyl-prolyl cis-trans isomerase"
                     /protein_id="WP_172164194.1"
                     /transl_table=11
                     /translation="MAQQKPEVDPHDGPAPADLLVTDLVVGDGAEARAGQNVEVHYVGV
                     AHSSGEEFDASWNRGSAFRFPLGAGRVIAGWDQGVVGMKVGGRRRLVIPPHMGYGDRGA
                     GGAIKSGETLIFVVDLLGVS"
     gene            13741..14256
                     /locus_tag="HOP40_RS27985"
                     /old_locus_tag="HOP40_28000"
     CDS             13741..14256
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013675939.1"
                     /locus_tag="HOP40_RS27985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_28000"
                     /product="metallophosphoesterase"
                     /protein_id="WP_172169352.1"
                     /sec_met_domain="Metallophos_2 (E-value: 1.4e-28, bitscore:
                     98.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLLILSDTHLPARARDLPAPVWDAVDAADVVIHAGDWISVAALD
                     ALEARARRLVGVHGNNDGDALRARLPEVARAELGGVRFAVVHETGSSKGREKRCSTAYP
                     DADVLVFGHSHIPWDSTTASGLRLLNPGSPTDRRRQPTHTWMTAEVDGGILGAVTLHHL
                     ETPHRVER"
     gene            14259..15215
                     /locus_tag="HOP40_RS27990"
                     /old_locus_tag="HOP40_28005"
     CDS             14259..15215
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018335071.1"
                     /locus_tag="HOP40_RS27990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_28005"
                     /product="ATP-dependent DNA ligase"
                     /protein_id="WP_172164197.1"
                     /transl_table=11
                     /translation="MAKEKAPKETREGVELSSLDGPLFDGSGATKRDLVDYLDAVSARI
                     LPGLAGRALSVVRVRPGQEPFMQKNVPKYAPDWIATTAAWAHASQREVHYALCDDRRTL
                     LWFANQRAVEYHPTLMRAGDTVATQLVIDLDPPVDDDFAHVVAAAALVRRALADSGLAG
                     ALKTSGAKGVHVVVPLEPSAVDDAAAATRALAARAAALDPAVATTAYIKEDREGKVFVD
                     STRAGGATIVAAYSPRVRPGAPVSFPVAWDDLAGVHPTDFTIRTAPGLLGDADPWAAAL
                     PAPQALPADLVEQGHTIPVARVAAMHEGKRRARARRQ"
     gene            15231..15536
                     /locus_tag="HOP40_RS27995"
                     /old_locus_tag="HOP40_28010"
     CDS             15231..15536
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013675940.1"
                     /locus_tag="HOP40_RS27995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_28010"
                     /product="antibiotic biosynthesis monooxygenase family
                     protein"
                     /protein_id="WP_172164200.1"
                     /transl_table=11
                     /translation="MITEIADFAVLPDKQEQFADAVREGLALAAQSPGFRGARLTRSIE
                     TPTRFVLFIEWDSVEAHTVGFRESELFPQWRAIVGPFFDGPPTVEHVEELVAHPGD"
     gene            15583..18351
                     /locus_tag="HOP40_RS28000"
                     /old_locus_tag="HOP40_28015"
     CDS             15583..18351
                     /NRPS_PKS="Domain: Abhydrolase_1 (59-165). E-value:
                     3.5e-11. Score: 35.1. Matches aSDomain:
                     nrpspksdomains_HOP40_RS28000_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104026.1"
                     /locus_tag="HOP40_RS28000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_28015"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_240157316.1"
                     /sec_met_domain="PF00561 (E-value: 8e-08, bitscore: 30.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRLPRVLLLALALLVLVPATALASPAPSSGPGSVTEARVDVPGA
                     TLDTTLYLPATTPAPAVLVAHGFGGSKASVDDDARALADRGFVVLAWSARGFGASTGQI
                     ALNAPDAEVADASALLDRLAAMPEVVQDGPGDPRAGVTGASYGGALALLLAGYDPRVDA
                     IAPVITWNDLGQALFPNAAAAGALPADTPARGAFAADGVFKRGWAGVFFSAGLGTGAPG
                     EPGTDDATRPAVPAAPAPGASPTCGRFTPEVCAAYTDAATTGRLSPATAALLERSSPRT
                     VTGRITAPTLLVQGEQDTLFGLDQADANAREIAANGTPVQVRWYAGGHDGAAPADDVRT
                     AVGDWFDHHLLGTGDDPGTTFSYGVESGLRAGSSTATGRTVVAAGYPGLAGAGAVPTQD
                     LALTGGARVVATPAGGSPAAITALPGLGGALGSLGGRISALTAALPGQSAQYASAALAD
                     PLLLTGAPRIDLTVSRVPGQPGPDEAILFVSASEVTPDGTRTLLGGAVAPVRVAVPADG
                     SPVTVPVTLPGVVAPVEAGNRVVVTVGTTDQAYAGGTDPAAWSVDAGTVLTVPVVPGEA
                     VTANTVPLGPAVGIGVVLGVALLAWGAAALLRRRGAAAVDPAPDAPPLEIRDLAKTYRG
                     GFSAVRGVSFRVERGQVLGLLGPNGAGKTTVLRMLMGLIRPTAGTMTAFGEPVGPGAPV
                     LARIGAFVEGPGFLPHLSGADNLRLYWAATGRPTAEAHLDEALEIAGLGASVQRRVGAY
                     SQGMRQRLAIAQAMLGLPELLVLDEPTNGLDPPQIHAMREVLRRYAAGGRTVLVSSHLL
                     AEVEQTCDHVVVMHHGQVVADGSVEDVIAGGGAATFAVDAPSRAADVLGALAGVHAVEV
                     DGEQVHAELNGTPRASAVRALVTAGVDVASAGPRRRLEDAFLQLVGEDGPS"
     aSDomain        15760..16077
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HOP40_RS28000_Abhydrolase_1.1"
                     /evalue="3.50E-11"
                     /label="HOP40_RS28000_Abhydrolase_1.1"
                     /locus_tag="HOP40_RS28000"
                     /protein_end="165"
                     /protein_start="59"
                     /score="35.1"
                     /tool="antismash"
                     /translation="PAVLVAHGFGGSKASVDDDARALADRGFVVLAWSARGFGASTGQI
                     ALNAPDAEVADASALLDRLAAMPEVVQDGPGDPRAGVTGASYGGALALLLAGYDPRVDA
                     IA"
     gene            18348..19256
                     /locus_tag="HOP40_RS28005"
                     /old_locus_tag="HOP40_28020"
     CDS             18348..19256
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241612.1"
                     /locus_tag="HOP40_RS28005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_28020"
                     /product="ABC transporter permease"
                     /protein_id="WP_172164203.1"
                     /transl_table=11
                     /translation="MTTPGPSTPGPSTRKGTVGALAAGPPPAAYRPGSTLPLRVELVRQ
                     LRRRRTQVTFGLVAALPVILWIAFSLAPDGPPTGSLNLVDLAQGSGTNFAVFALFASAG
                     FLLVVVVALFFGDTVAAEASWSSLRYLLAAPIPRTRLLRQKAVVAAGLSLAAILTLPLV
                     ALLVGGLAYGAGNLVSPTGESLTFAAGAGRVLLGALYVAVQLSWVAALALLLSVSTDAP
                     LGAVGGAVMASIVSQILNQITALEDLRDFLPTRFSTAWSDLLATDVDWDAMTRGVFSSL
                     TWALVLGAAAVYRFGRKDVTS"
     misc_feature    complement(19321..19335)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            19349..20200
                     /locus_tag="HOP40_RS36145"
     CDS             19349..20200
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HOP40_RS36145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_240157317.1"
                     /transl_table=11
                     /translation="MTSSTDRGPGAADYGRTPDHGPAPHDRVGDHRAPDHRDPDPRGTD
                     PRGVDPRGTDPRDNDPRGVDQRGVDQRPPGTYAAGGGHADAPTVATGTAGGTALTPRQQ
                     RRAARTEQRRQFGGIKWGSAFFGWLTALGTAVLLSGIVAGVTEGYGLTTAPGGPPEGIV
                     AAIVVAVVLFLAYFCGGYVAGRMARFDGARQGVAVWIWAVLVAVAVTVLIAVSGTPVDL
                     TPVAALVGGVVDPSAFTPAAIGALAAALVVGLVGAVLGGLAGMRFHRRVDRAVPPVPTA
                     TP"
     gene            complement(<20239..21090)
                     /locus_tag="HOP40_RS28010"
                     /old_locus_tag="HOP40_28025"
                     /pseudo=""
     CDS             complement(<20239..21090)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005459974.1"
                     /locus_tag="HOP40_RS28010"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_28025"
                     /product="EamA family transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPLRDRLLAVLVAALWGGNFLAIHVGLEHFPPLFLAALRFALIAV
                     PTVLLVPRPQVPLRWLLGYGLGFGTVQFIGLFVAMDIGMPPGLASLVLQASAPFTVLLG
                     ALLLRERLAVRQGVGIGLAVLGLAAIVVARAQTAAVLPVLLTLLGALGWAFGNLANRLA
                     HAPNPLHLTLWMSVVPPVPLLAMSWLTEGPQAGLDALVAAAGPSGVPGLLALAYLVVPA
                     TVLGSGIWTWLMGRHPAGVVAPYSLLVPVVGMGLAAVVLGERPSLVELVAGTVIVGGVL
                     LGT"
     gene            21162..22073
                     /locus_tag="HOP40_RS28015"
                     /old_locus_tag="HOP40_28030"
     CDS             21162..22073
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420275.1"
                     /locus_tag="HOP40_RS28015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_28030"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_172164209.1"
                     /transl_table=11
                     /translation="MDVQRLRVLRELADRGSVTAVAAALSFTPSAISQQLRALAEEVGT
                     ALTEPAGRGLRLTDAGRVLAAEAEEVLAALARAEAAVEGLRTTPRGLVRVALFPSAARM
                     MLAGVLARLDAAPGVEVACRDVDMSPAAVVALTADFDVVVTHRDEHGPGTAPGRHVVPL
                     LREPLDVVLPPGHRLARRRRLRLDELAGESWISVEVGWPVDDVLRSLAVRTGTAPRVVQ
                     RINDFSVTEELVAAGRGIALLPRYSTDDRGGRRLVRRPLAGVRAARLVEAVLRPSAAAR
                     PAVRTVLDALVAEAAAITSRAG"
ORIGIN
        1 tcgtcgacgt cgacgaggac gtcgtgctgt tccgcgcgag caccgacccg gtgtcggtgg
       61 ggctgtggac gtgggaccgc gacggcctcg tggaggtcgc gaccaccccg ggcgtgcacg
      121 cggggcggcg cgcgggcggc acgaccgtcg tcacgagcgg tgacctgcgg tccgacggcg
      181 cccgcaccgt cgtgcgccgc ggcgaggtcg agcggacggt cacctcgctc gccgaggccc
      241 cgggcctgga gtccgccgtc gcgctgttcg aggtgggcga gcgcgggctg cgcaccgcgg
      301 tgctgctccc ctcctggcac acgcccggca cgaagctgcc ggtcctcatg gacccctacg
      361 gcggcccgca cgcccagcgc gtcacggcgc tgcgcgcggc ccacctcacc agccagtggt
      421 tcgccgacca ggggttcgcc gtcgtcgtcg tcgacgggcg gggcacgccg gggcgcgggc
      481 cggagttcga gaaggccgtg cacggcgacc tcgcgtcgcc cgtgctggag gaccaggtcg
      541 acgccctgca cgccgtcgcg gcctcgctgc ccgacctcga cctcacccgc gtcggcatcc
      601 gcggctggtc cttcggcggc tacctcgccg cgctggccgt gctgcgccgc cccgacgtct
      661 tccacgccgc ggtcgccggc gcccccgtca ccgactgggg cctctacgac acccactaca
      721 ccgagcgcta cctcgggcac ccggcgcagc acccggacgc ctacgcgcac tcctcgctga
      781 tcgccgacgc cccctcgctg gcgcggccgc tgctgctcgt gcacggcctc gccgacgaca
      841 acgtggtggc cgcgcacacg ctgcggctct cgtcggcgct gctcgcggcg gggcgcccgc
      901 acagcgtcct gccgctgtcc ggggtcactc acatgacgcc ccaggaggtc gtcgcggaga
      961 acctcctgct cctgcaggtg cagttcctcc gaacggctct cggactgccg ccgcagggcg
     1021 cagcgtcgtc aggaccgagt ggtccagccg actgaccgta acgggcgata ccgcccctcc
     1081 gatgagtccc cgagtgctac acagcgtagg cagtgcggga ggatccgggc gtgcgggacc
     1141 agcggcgaga cgaccccgag tcgacgacga gcttcgtcgc cggccggccg aagatcgaca
     1201 cggccaccga caagatgccg gcgcggcgcg agggcccggt gccaccggtc ccgccggccc
     1261 gccgggcccc ccgcgcgggg cgcccggtcg tgccaccccc ggccgctccg gtcgacgcga
     1321 cggtggccgg cccgctggtg cccggagcgc cgtcggtgcc cgtcgtcccg gtcgtcaccg
     1381 ccgccgccgc gctcacggcc gcggtgccgc aggtcgtcgc cgctccggcg ccggtgtcgc
     1441 cggtgcccct ggcccgtccc ggcggtcccg gcggtcgtcc gcccgccccg cgcaccggca
     1501 ccggtccggt gggacggccc ctgcggcccg aacccctgcg gcccgaggga ctgcgccccg
     1561 agcccgtgcg ccccgagccc ctgcggcccg agccggtccg ggccgcctcc ctgcccgagc
     1621 cgcccgtccg gcgtccggcg ccggagatcc cgtcgcagcg cacccggccg ccggcgcccg
     1681 cgccgcgccg ccgccggcgg cggctgcagc cggtcgtgct cgcggccgcc gccgtcgcgg
     1741 cggccggcgg ggtcacgtgg ggggtgctct cggtcggcgc gcccgatcgg gagcccgcgc
     1801 cggtcttcgg ggtgccggtg gtgttccagc acgccaccgc gctcgacgag gcgggagcgc
     1861 gctaccgcga cttcgtcgtc gccgaggccg acgcgctgcg cgagagcacg gccgacctcg
     1921 tcgccgccgt gcgggccggg cgcgtcgccg tcgcgcagga ccgctacccg gccgcgcgga
     1981 cgcactggga gcgcatccag gtcgccaccg aggccgtcac cggccccgac ggcgaggagc
     2041 tcggacccgc gatcgacggg cagggggtcg gcatggaccc gggcgagacg ttcaccgggt
     2101 tccaccgcct cgagcgcgac ctgtgggtcg acggcctgca gcccgacacc cggcaggtgg
     2161 ccgacgacct gctcgccgac gtcaccgcac tggcccaggg cgcggtcgcg ctcgagctgg
     2221 gcgggccgga cctgtgcggc agcgccaagg agctcgtcga cttcgccgtc gtcaccacgc
     2281 tctccgggcg cgagaaccgc ttcgccggca ccgacatgtc cgacctcgcg gcgcgcgtcg
     2341 agggctcgga ggccgcggtc gaggcgctgc ggccgctgct caccgacgtc gaccccgcgc
     2401 tgctcacgga gctggaccgc cggttcgccg agacctacgc cgtcctggac cgctaccgca
     2461 ccggcggcgg gttccggccc tacaccgaca tgaccgcggc cgacctcaag gccgtcgccg
     2521 acgtcctcga cgcgctgggc gaaccggtca gccacgtcgg cggggcggtg ctcgtctgat
     2581 gccgcgcatg aaccgccgca ccctgttcgg catcgccggc gccggggccg ccgccgccgc
     2641 gggcgccggg gccgtgctcg ccgccgagca cgtcctgccc gcctccgtcg ggggcgggcc
     2701 cgacgacgtc gtcccgttcc gcggggcgcg ccaggccggg atcaccaccg ccgcgcagga
     2761 ccacctgtac ttcgtcgccc tcgacgtcac caccaccgac cgcgccgagc tcgtcgacct
     2821 gctgcagcgc tggacgctcg cggccgagcg gctcaccacg ggcgcggagg tcgccgtcga
     2881 cggggccatc ggcgggcacc ccgaggcgcc gccgcaggac accggcgagg cgctcggcct
     2941 gccgccggcc cggctcacgc tcacgttcgg cgtcggcccg agcctgttca cgcgcgacgg
     3001 cgtcgaccgc ttcggcatcg ccgaccgccg cccgccgaag ctgatcgacc tgcccctgtt
     3061 cgccggcgac gccatcgagc ccggccgcag caacggcgac ctgtgcatcc aggcctgcgc
     3121 cgacgacccg caggtcgcgg tgcacgccgt ccgcaacctg atccggatgg gcttcggcac
     3181 cacggccgtc cggtgggcgc agatgggcta cgggcgcacg tcgtcgacgg tggtcgggca
     3241 ggcgacgccg cgcaacatgt tcggcttcaa ggacggcacc tccaacatca ccgccgagga
     3301 caccgccggc ctcgcccgcc acgtctgggc ggccgcggag gacggcgccg actggatgac
     3361 gggcggcagc tacctcgtcg cccgccgcat ccggatggcg atcgagccgt gggaccgcac
     3421 ctcgctgctc gagcaggagg agatcgtcgg gcggcacaag ggcagcggtg ccgccctggg
     3481 tgccaccgac gagttcgccg aggtcgactt ctccgccacc cgacccgacg gctccggccc
     3541 gctggtcggc atggactcgc acgtgcgcct cgcccactcc tccaccctgg gcggggtgcg
     3601 gatcctgcgc cgcggctaca acttcatcga cggcaccgac gccgagggcc acctcgacgc
     3661 cggcctgttc ttcatcgcct tcgtccgcga ccccggcgcg cagttcgtgc cgatgcagca
     3721 ggcgctgtcg acgaaggaca tcatgatgga gtacctggtg cacacgagct cggcgctgtt
     3781 cgcctgcccg ccgggtgtgg gcacgggcga ccactggggc cgcacgctct tcggcaaccc
     3841 cgcctagcgg tccgcacccg cggcaccggg acgccacccc gtttgtcccg gcgcccgggt
     3901 cgggcgcacc atgtcgcccg tggacgtcga ctgggccgcg tggctgaccg ggctggggat
     3961 cgccgccgcg gtctggggcg tgctgtgcgt cgtcatggtg ctgctggcca gcaggctgcc
     4021 gccgggtctg ctccgcgaca tcgcggagtt cctgcccgcc tgcgtcacga ccgcccggcg
     4081 gctgcgccgc tcccccgcgg tcccgcggcg cgcgaaggtg gccctgctgg tggcgatcat
     4141 ctgggtggtg tcgccgatcg acctgctgcc ggagttcctg ccggtgatcg ggccgctcga
     4201 cgacgtcgtc gccgtggtgc tcctgctgcg ctacgccgcg cgctcgatcc cgcgcgacca
     4261 gctcgtcgcg gcctggcccg ccgagctccg cctgctcgaa aggctgctgg acggccgccg
     4321 ccgacccgac cgcgacccgg agccccggta gcgggtcgcg gcccgacctg gttccctcgg
     4381 gggtgacgca ggtgacgtcg ggaggtggtg ggggtggacc agggcacgct gcaggcctcg
     4441 cccacgcggt ggatctgcga gccctgcggg ttcgtctacg accccgccga gggcgacccg
     4501 gacagcggca tcgaaccggg cacgcccttc gaggacatcc ccgacgactg gatgtgcccc
     4561 atctgcggtg ccaccaaggc ggacttccgc gagctggagc cgggagagtt cccggaggac
     4621 tgaggaccac ggtcatgatc accggatacg cccacttcgc acagctggcc gagtcgctgc
     4681 agtgggacga gaaggccatc gacttctcgg cggaccgcga ggcctggccg cggctgaccg
     4741 gggcggagaa cgcgcgggtg ctcgggctgg tcgccgggtt cgtcatcgcc gagacctcgg
     4801 tgtccgggca gctcggcgcc tacgaggcgg cggcgcccga cgagtcgatg gcggcggtct
     4861 tccaggccca ggcccgggac gaggcgcgcc acgcccgctt cttcgaccgc gtctccgccg
     4921 aggtcgcctg cgtccccggc gagctgcccg cgcagcggcg ggacgcgctg cgcgcccacg
     4981 tcggcgacga gctggtcgac ctgttcgagc accgcctgcc ggccaccgca cggcggctcg
     5041 ccgaggacca cgcgggcctg acggccgcgg tcggcctcta ccacatggtg atcgagggcg
     5101 tggtcctgct ggcggggcag cacgcgatgc tcgacgcgct cgagggcctg tcggtcgggc
     5161 tgccgggggt gcgcaagggg atggagctgg tgctgcgcga cgagcgctgg cacatcgggt
     5221 tcgggtcgcg cgtcgtgcag agcgcggcga tcggccggga ggaggccgac gcgctgctcg
     5281 agcagggcga gacggccgcc aaggtctggg gggacctcat caccaccgag gccatcgaga
     5341 ccgcagtgcg ccagcaccgg cgccggctca aggccgccgg catcaagttc tggtgaccgc
     5401 ggcccgctga ccgatctcgt cgcgccacat cgaggccttg gtgcggtgcc ccgccgccac
     5461 gacgacgtcc cgctcgtcga gcagctgctc gaacgccgtg gcggtggcca gcacctcccg
     5521 gggccagcag cgggtggaga gctcgagcag ctcccggccg ctcgggtacc ggaagtgctc
     5581 caggtcggcc cggtgcaggc ccagccggtc ggccccgacc ttgacccggc ggaccaccag
     5641 gggcccgtgc acccccagcc ggcgcaggtg cccctcgtcc acgcacccgt gcgcggcgcg
     5701 gcgcgcccac gcggactggt ccgcggtgag cagctcccgg gaccgggccg cgccggcgat
     5761 cacgtcggcc gccgccgccg cgtcgacctc ccgccggacc tcgacgtcct gccacagcgc
     5821 ccccggcacg acgtcgacct ccacgcgcac cccgcgcggg aacgcccgcc ggcgggcgtc
     5881 gccgctgcgg caggtggaca ccgacaggtc gaagcggccg cgggcccggc gccgcaggcg
     5941 gacctccacc ccggcctcca gcaggtccag ggccggggtg tcgagcaggt acgtctggcg
     6001 cacgctccac gtcggcgcgc accgcccggt cagcgcctcg gcggccggtc cggccggggg
     6061 cacgagcagt gccttcagct cgacgctgtc ggcgtgcgcg caccgggcgc tgagccgcgc
     6121 cagcgcctcg ggtgatccga acctccgcac gagcccccct gcgtggacgg tccggccggc
     6181 gtccgcgtcg acgtcggccc cgtcgcacta taggaccgcg accggctccc ggacaccgcc
     6241 tcggcgggcc ggatccacgc cgtcccgggg ccgccgggac ggcgatccac atcgaccgcc
     6301 gctcccccct tgccgatctc ggacccgctc cgtagggtcg aatgtggctc agcacacact
     6361 tccgatggcc gttctcgaca gcgccgcgga cccgtgtcct gccgccccag tggtcgacat
     6421 catcggcaga cggccgagtg accccgtggc ggcacccctg tgcccggctg cgcggtgctc
     6481 ggctgcgcac gcatggaggc gcacgtggga gtgcccgtga gcgggtccgg gatcgccggg
     6541 agcacccggt tccccgtccg acgagcctcc tccgccgacg atccccgacc cgccacggcc
     6601 ctccggccgt ggacgaccga cgaggagggg aggacccagg tggtggcgac gctgccgtgg
     6661 gcaggacgga cgttcgtgac gaggaggtac ggcagatgac gacgacagac gatccctcgg
     6721 gcaagctggc cgacggcctg caccggcaga acgcgaccgg cctgggccgg ttgctcggct
     6781 ccggcggcgt cgggcacgcc gaggaggggc ccgacggcac catgaccgcc accgtccgga
     6841 tccccgagga cgagctctgc ttcgagcccg ggaccctcat cctgccccac ggcgggaacc
     6901 tcgagctcac gctcatcaac gacgacaaga acacccactg cgcggtgctg ccgcacaacg
     6961 gggaccccaa gatcatctgg ttggtgaacc actcgaaggg cacggcctcg ctcaacctgg
     7021 acggcccggg cacctactac tacgggtcca cgaccgggaa cgacgagggc cgcggcctga
     7081 ccggcgccat cgtcatcggc ggggaagtac cggaccacgc caagctcgac cgcccgccgc
     7141 agccgcgccc gtgagatgag gagcagacca tgaccgacta cgtcgacgcg ggcgccgcga
     7201 tcccgcagat gcagctcagc gccatcaagg gcagtgcgcc cgccacgggc aacgtggacc
     7261 acgaccgcat cctgcgcgcc cgcacggagc cggagaactg gctcacctac tacggcacct
     7321 tcgacggtca gcgctacagc gagctcgacc agatcagcaa ggacaacgtc cggcgcctgt
     7381 cccccgcgtg ggtgttccag gccggttcga cgggcatgca ggccggcgcc tcgacctact
     7441 cgttcgaggc ctgcccgatc gtcgtcgaag gggtcatgta cgtctccggc cccgacggcc
     7501 ggtgctgggc gctggacgcg aagaccggtg cggagctctg gcggtacaag cacgcctcgc
     7561 cctacgacgt ctcgctgtgc tgcggcaacg tcaaccgcgg ggtggccgtc gggcacggga
     7621 aggtctacat ggccaccctc aacgcccacg tgatcgccct cgacgccacc accggcgaga
     7681 aggtctggga caccaccgcc ggtgacgtgc gggccgggga gagccgcacc gtggcgccgc
     7741 tgctcgtgaa ggacatggtc atcgtcggca gctcgggcgg cgagttcggc acccgcgggt
     7801 gcctcgacgc cttcgacgcc gacaccgggg agcgccgctg gcggcgctac atgatcccga
     7861 agccgggtga gcccggttcc gagacctggc ccgacgacgg cgaggcgtgg cagcgcggcg
     7921 gggcgaactg ctgggtcacc ccgacctacg acccggagct ggagctgctg ttcccgggca
     7981 ccggcaaccc ggcgcccgac ttcgacggcg gggtccgccc gggcgacaac ctctacaccg
     8041 acagcgtcgt cgcggtggac gtgaacaccg gcgagatccg gtggcactac cagttcaccc
     8101 cgcacgacct gtgggactac gactccacga tggagaacct gctgttcgac gcgcccgacg
     8161 gccgcaagct gatggcgcac gcggacaaga acgggtactt cttcgtcctg gaccgcacca
     8221 acggcgagct ggtgcgggtc ttccccttcg tcgaccggat cacctggggc gagatcagcc
     8281 ccgacggcaa ggtcacgccc aagctgtacc cggacgagga gggcgtcccg gtgcacttct
     8341 ggccggggcc ggccggcggc aaggagtgga cgcacatgtc ctacagcccc cagacggggc
     8401 tggtgtacat cccggtgcag gaggtcgggg ccaccgcgac ccggcggcgc cgcgagttca
     8461 aggagagcat cccgtactgg ggcgcgggcg tcgccgtgga cctcgaggac ttctacggct
     8521 tcgtgagcgc cgtcgacccg ctgaccggcg aggagaagtg gcgctggcgc tacgagtacc
     8581 cgatgacggc ctcgacgctg gtcacggcgg gcgggctggt cttcgtgggc cttgcgacgg
     8641 gtgagttcat cgccctcgac gcggcgaccg gggagaagct gtggcagttc cagtgcggca
     8701 gcggccacca cagcagcccc agcacgtaca gcatcgacgg ccggcagtac gtcgcggtgc
     8761 cgaccgggtt cggcgggtgg gtcgagggct tcacgcccgg gctgctcggc gccgcgtcgg
     8821 gcgactcgct gttcgtcttc gcgctgcccg aggactaggt ccgcaccccg cacgacacgc
     8881 aggagggagg tgacggcaca tggagcgtct cgccgagtgg gaggcgcccg acttcgacga
     8941 agtcgggtgt gcgcccgagg tgacgatgta catcgctcgc tcggaggact gaggccgacg
     9001 gcctgaggac gacgacggcg gacgacggac ggggaggggc gccgggacac gggttccggc
     9061 gcccctcccc ggcgtcgagg acgggggcgc gaatgcgggt gcgggtgctg ggatcggcgg
     9121 cgggaggggg ctacccgcag tggaactgca gctgcccgac gtgccgggcg gtccgcgagg
     9181 gcacccggcc ggcccgggcg cgcacgcagt cctcgatcgc cgtgagcccg gacggcgagc
     9241 ggtggttcct ggtcaacgcc tcccccgacg tccgggcgca ggtcgaggcg ttcccgcgcc
     9301 tgcaccccgg cgccggccgg gccacgccgc tggaggcggt gctgctcacc gacgccgagc
     9361 tcgaccacac cctggggctg ctcctgctgc gggagggacg tgggatcgag ctgcacgcca
     9421 ccgcggcgac gcacgcgacg ctgaccgcgg gcaccggcgt gctgaccacc ctggagcgct
     9481 actgccccgt cgggtggacc cccgtcgtcc cggggaagga ggtgtcgctg ggcggcatct
     9541 cctaccaggc gttcgacgcc cccaccggca agcacgaccg cttcggcggg ggcaccggcg
     9601 aggggcgggt cgtgggctac cggttcaccg acgaggccac cggggccgcg gcggtctacc
     9661 tgccgggcgt gcaggagctc acgccggccg tgctcgccga gctcgagggc gtcgactgcc
     9721 tgctcgtcga cggcacctgc tggcacgacg acgagatgat ccgcctcggc ctggccgcga
     9781 agacggccca cggcatgggg cacctcgccg tcggcggccc cgggggcagc ctcgagcagc
     9841 tggccgggct gccgatcgcc cgccggatct acgtccacat caacaacacc aacccgatgc
     9901 tgctcgagga ctcgccggaa cggcgccacg tcgagcggtg cgggatggaa gtggcccacg
     9961 acggtctcga ggtggaggtc cccgcacgat gacggacacg atgacggaca cggacgcgat
    10021 gacgacggga gcgccccccg aggtcgacgc cctcgtcgag cggctgcgcg cgcactcgca
    10081 gagctaccac agcgcgcacc cgttccacct gcggatgaac gagggcctgc tcgctcccgc
    10141 ccagatccgc gggtgggtgg ccaaccgcta ctactaccag gagatgatcc cgcgcaagga
    10201 cgccgcgatc ctcgccaact gcccggaccc ggcggtgcgc cggcgctgga tccgccgcat
    10261 caccgaccac gacggcaccg cggacggcga gggcggcatc gaggcgtggc tgcgcctcgg
    10321 cgaggcctgc gggctgcggc gcgaggagat cgccgaccac cgccacctcg tgccgggcgt
    10381 gcggttcgcg gtggacgcct acgtcacgtt cgcccggacg cggccctggg tggaggcggt
    10441 cgcgtcgtcg ctgaccgagc tgttcgcgcc ggacctgatg gccgagcgcc tccgggcgtt
    10501 cgagcagcgc tacacctgga tcgcaccgga gggcctggcc tacttccgca accgcctgga
    10561 gcaggcgccc cgcgactccg agcacgccct ggaggtggtg ctgcggtact gccggaccct
    10621 gcaggaccag gacgcggcgg tggccgcgct gtcgttcaag tgcgacgtcc tgtggtcgat
    10681 gatggacgcg atcgaccagg cgtacgggga ccggtcccgt gccgggtgac gtcccgccgt
    10741 cgggccgccc ggcgctggcg cgccacgtcc ggatgcggtt cgacccgacc cgcgagcggc
    10801 acgtgctgct gggcccggag tcggtgatcg tgctcaaccc gaccggcgcc gacatcctcg
    10861 gcctgtgcga cgggcggcgg accgtgtccg acgtcgccgc ggcgctgcgg gtccgctacg
    10921 agcgggtggt ggacgacgag gtgacggcgt tcctcgcccg gctcgtcacg aagcgatgtg
    10981 tggagatcag tgatggatag gcccttcgga ctgctggccg agctcaccta ccgctgcccg
    11041 ctggcctgcg cctactgctc gaacccgctc gagctcgccg cctacgacga cgagctgggc
    11101 accgccgagt ggcagcgcgt gttcaccgag gccgccgcga tgggggtgct gcagtgccac
    11161 ctctccggcg gcgagccgct gctgcgccgc gacctcgtcg agctggtgcg cacggccgcg
    11221 gacctcggca tgtacacgaa cctggtgacc agtgcgatcg ggctctcgcg cggccgcgcg
    11281 gaggagctga aggaggccgg gctcgaccac gtgcaggtca gcgtgcaggc cgacgagccc
    11341 gccacctccg accgcatcgc cggcatcccg tcgttcgagc gcaagctccg ggcggccgcc
    11401 gtggtgaagg agctcggctg gccgctgacg gtcaacgtgg tggtgcaccg gcagaacatc
    11461 gaccgcctcg ccgagatcat cgcgctggtc gaggagctcg acgccgaccg cgtcgagctg
    11521 gccaacaccc agtactacgg ctgggcgtgg cgcaaccggg cggcgctgct gcccagccgc
    11581 gcccagctcg ccgccgccga ggacgtcgtc cgcgccgcgc gcgagcgcct ggcgggccgg
    11641 atggaggtcc tgcacgtgct ggccgactac tacagcgcgt accccaagcc ctgcatgggc
    11701 gggtgggccg cgcgccagct gaccgtggcc cccaacggcg acgcgctgcc ctgcccggcg
    11761 gcgcagaccc tgccgctgcc gcgggccagc gtgcgggagg agtccctgca gcggatctgg
    11821 gacgacgccc cggtgttcac cgcgttccgc ggcaccggct ggatgagcga cccctgccgg
    11881 acctgcgacc gccgcgagat cgacttcggc gggtgccgct gccaggcgtt ccagctcacc
    11941 ggcgacgccg cccgcaccga tccggtgtgc cacctctcgc ccgaccacgc cctcgtggcc
    12001 gacgccgtcg aggcggccaa cgcgggaggc cgacggcacg aggaggtgct cgtcccgcgt
    12061 ccgcaccgcg cctgagtgcg ggggacggtg ggtggggcta gtcgacctcg atcgggggtc
    12121 ccccgagcac gacgaagctc aggacccagt aggcgacgta cagcgcgagc aggacgaagc
    12181 cgtgccaccg ctgcaaccgc ccggtccaca ggaagtacgc cgcgagaccg gtcaccgcga
    12241 tgagcgcggt caggtgccag gtgagcacgt ccggaccgac gacgatcgcg ccgcccgcga
    12301 ggatgatgac gccgagcttc ccggtcaccg agaagacgac gctcccgatg acgttgccga
    12361 tcccgacctc cggcgcgccc ctccggatgg gctccaccgt caggaagacg tcctccaggg
    12421 tcaggacggc ggtgacgatc gtggcgccga agagcgtgcc ctcgatcccg taggcctcca
    12481 ggatcccctc gacgccgatg cccgtggtcg ccgcgccgac gacgagaccg gtgagcgcga
    12541 gcagcgccag cgccagcccg gcccagccgg ggagcctgcg cgcctcggcg aagggcatct
    12601 cgtcggcgaa cgacgtcccc ggcgcctgct ccccctccgc cgggtccccc tccgcccggt
    12661 cctcccgccc gccgccggtc tccaccatcc ccgcgtagat ctcggcgttg cggaagaccg
    12721 ggatcgcccg ctgggactcc cggaccgcga cgtaggtgat gaacagcacg aacagggcga
    12781 cgagcacgac gccgtcgacg agggtcagcg gcgccgtcag cgtgaacacg atcatcacca
    12841 gcggtgctcc ggccagcagc gccacgtagt cgcgcgggat ctgcagccgc accggggtga
    12901 ggatcgcggc gatcgcgagc acgaccccgg tcagcgagat cgccgtgccg aagaccgtgc
    12961 ccagcgcgac gccgctgagg tcctcgaggt tcagcgcgac cccgaggaag atgtcgtcga
    13021 actcgatgcc cgtgaagacg atcgcgagca ggaacagcga gacccgcagg ccgctcgcgg
    13081 cccccacgag gtagccgatc agcttctcgg cgctgaacac cagcagcgtc gcgccggaga
    13141 tgaacacgaa cacggaggtc atgcgacttc cccctcgcac cggccgcact gccgacatcg
    13201 tgcggttccc cgcaaccgcg ccccgatggt cgcaaaccgg cgtcgtcgcc cgctagtgcc
    13261 gaagcaccgc gcgttcccgg gatcgctccc ggcaccccgt cagccggtct ggcaggctgt
    13321 cgtccgcgca ccccaccaac gagaggacca ccgtggccca gcagaagccc gaggtcgacc
    13381 cgcacgacgg cccggcgccc gccgacctgc tcgtcaccga cctcgtcgtc ggcgacggcg
    13441 ccgaggcccg cgcgggccag aacgtcgagg tgcactacgt cggcgtcgcg cacagcagcg
    13501 gcgaggagtt cgacgcctcc tggaaccgcg gctccgcgtt ccgcttcccc ctcggcgccg
    13561 gccgcgtcat cgcgggctgg gaccagggcg tcgtcggcat gaaggtcggc ggacgccgcc
    13621 ggctcgtcat cccgccgcac atgggctacg gcgaccgcgg cgccggcggc gcgatcaaga
    13681 gcggcgagac gctgatcttc gtggtcgacc tgctcggcgt ctcctgatcg gaccggggcc
    13741 ctgcacctcc tgatcctcag cgacacccac ctcccggcgc gggcgcgcga cctgcccgcg
    13801 ccggtgtggg acgccgtcga cgccgcggac gtggtgatcc acgccggcga ctggatctcc
    13861 gtggccgccc tcgacgcgct ggaggcccgc gcgcggcggc tcgtcggcgt ccacggcaac
    13921 aacgacggcg acgccctccg cgcccggctc cccgaggtgg cccgcgccga gctcggcggg
    13981 gtccggttcg ccgtcgtgca cgagaccggc tcgtcgaagg gccgggagaa gcgctgctcc
    14041 accgcctacc ccgacgccga cgtgctcgtg ttcgggcaca gccacatccc ctgggactcc
    14101 acgacggcgt ccgggctgcg gctgctcaac cccggctccc ccaccgaccg gcgccggcag
    14161 ccgacgcaca cctggatgac ggccgaggtc gacggtggca tcctcggcgc ggtgaccctg
    14221 caccacctgg agaccccgca ccgcgtggag cgctgacggt ggcgaaggag aaggcgccga
    14281 aggagacccg cgagggcgtc gagcttagca gcctcgacgg ccctctgttc gacggctccg
    14341 gcgccaccaa gcgcgacctc gtcgactacc tcgacgccgt ctccgcccgg atcctgcccg
    14401 ggctcgccgg gcgcgcgctg tcggtggtgc gcgtgcggcc ggggcaggag ccgttcatgc
    14461 agaagaacgt cccgaagtac gcgcccgact ggatcgccac cacggcggcg tgggcgcacg
    14521 cctcgcagcg cgaggtccac tacgccctgt gcgacgaccg ccgcaccctg ctgtggttcg
    14581 ccaaccagcg cgcggtcgag taccacccga cgctcatgcg ggccggggac accgtcgcga
    14641 cgcagctcgt gatcgacctc gaccccccgg tcgacgacga cttcgcgcac gtcgtggccg
    14701 ccgccgcgct cgtgcggcgg gcgctggccg actccgggct cgcgggcgcg ctgaagacga
    14761 gcggtgcgaa gggcgtgcac gtcgtcgtgc cgctggagcc gtccgccgtc gacgacgccg
    14821 ccgcggccac ccgcgcgctg gccgcccggg ccgcggccct cgaccccgcc gtcgcgacca
    14881 ccgcgtacat caaggaggac cgggagggga aggtcttcgt cgactccacc cgggccgggg
    14941 gcgccacgat cgtcgcggcc tacagcccgc gcgtgcggcc cggggcgccc gtgtcgttcc
    15001 cggtggcctg ggacgacctc gcgggcgtcc accccaccga cttcacgatc cgcaccgccc
    15061 ccgggctgct cggcgacgcc gacccgtggg ccgccgcgct gcccgcgccg caggcgctgc
    15121 ccgccgacct cgtcgagcag ggccacacca tcccggtcgc ccgcgtggcc gccatgcacg
    15181 agggcaagcg gcgggcgcgg gcgcgccggc agtgatgcga ggatgaggcc atgatcaccg
    15241 agatcgccga cttcgccgtc ctccccgaca agcaggagca gttcgccgac gccgtgcgcg
    15301 agggcctcgc gctcgccgcg cagagccccg ggttccgcgg cgcccgcctc acccgcagca
    15361 tcgagacgcc cacccggttc gtgctgttca tcgagtggga cagcgtcgag gcgcacaccg
    15421 tcggcttccg cgagtccgag ctgttcccgc agtggcgcgc gatcgtcggc cccttcttcg
    15481 acggcccgcc gacggtcgag cacgtcgagg agctcgtcgc gcatcccggg gactgagagg
    15541 cggctgaggg cgggtcacgg ccggtcgcct agcgtcgcag gagtgccccg cctcccgcgc
    15601 gtgctgctgc tcgcgctcgc gctcctcgtg ctcgtccccg ccacggccct cgcctccccc
    15661 gctccgagct cgggcccggg gagcgtcacc gaggcgcgcg tcgacgtccc cggggccacg
    15721 ctggacacca cgctctacct ccccgcgacg acgccggccc cggcggtgct ggtcgcccac
    15781 ggcttcggcg ggagcaaggc ctcggtcgac gacgacgccc gcgcgctcgc cgaccgcggc
    15841 ttcgtcgtgc tcgcctggtc ggcccgcggg ttcggcgcga gcaccgggca gatcgcgctc
    15901 aacgccccgg acgccgaggt cgccgacgcg agcgcgctgc tcgaccggct cgccgcgatg
    15961 cccgaggtcg tgcaggacgg gccgggcgac ccgcgcgcgg gcgtcaccgg ggcgtcgtac
    16021 ggcggggcgc tcgcgctgct gctcgccggc tacgaccccc gcgtcgacgc gatcgccccg
    16081 gtgatcacct ggaacgacct gggccaggcg ctgttcccca acgccgccgc ggccggtgcg
    16141 ctgcccgcgg acaccccggc gcgcggcgcc ttcgccgccg acggggtgtt caagcgcggc
    16201 tgggccgggg tcttcttctc tgcgggcctg ggcacgggcg cgccgggcga gccgggcacc
    16261 gacgacgcca cgaggcccgc cgtccccgcc gcccccgcac ccggcgcctc ccccacctgc
    16321 ggcaggttca cccccgaggt ctgcgccgcc tacaccgacg ccgcgacgac cgggcgcctg
    16381 tccccggcca cggcggccct gctcgagcgc tcctcccccc gcaccgtgac cggccggatc
    16441 accgccccga cgctgctggt gcagggcgag caggacacgc tgttcggcct cgaccaggcc
    16501 gacgccaacg cccgcgagat cgccgcgaac ggcaccccgg tgcaggtgcg ctggtacgcg
    16561 ggcgggcacg acggcgccgc cccggccgac gacgtgcgca ccgcggtcgg cgactggttc
    16621 gaccaccacc tgctcggcac cggcgacgac ccgggcacga cgttctccta cggcgtcgag
    16681 agcggcctgc gcgccggcag cagcaccgcg accggccgca cggtcgtcgc ggccggctac
    16741 cccggcctgg ccggggccgg cgcggtgccg acgcaggacc tcgcgctgac cggcggcgcg
    16801 cgcgtcgtcg ccaccccggc gggcggcagc cccgccgcga tcaccgcgct gcccgggctc
    16861 ggcggggcgc tgggcagcct cggcggccgg atctccgcgc tcaccgcggc gttgcccggc
    16921 cagtcggcgc agtacgcctc ggccgcgctg gccgacccgc tgctgctcac cggcgcgccc
    16981 cggatcgacc tcaccgtctc ccgcgtcccc ggccagcccg gccccgacga ggcgatcctg
    17041 ttcgtctcgg cctccgaggt caccccggac ggcacgcgca ccctgctcgg cggggccgtc
    17101 gcgccggtgc gggtcgcggt ccccgccgac ggctccccgg tcaccgtccc ggtgacgctg
    17161 cccggcgtcg tcgcgccggt ggaggcgggc aaccgcgtcg tcgtcacggt cggcaccacc
    17221 gaccaggcct acgcgggcgg caccgacccg gcggcctggt ccgtggacgc cggcaccgtg
    17281 ctgaccgtcc ccgtcgtgcc cggcgaggcc gtcacggcga acaccgtgcc gctcggcccg
    17341 gccgtcggga tcggcgtcgt gctgggcgtc gcgctgctgg cctggggcgc ggccgcgctg
    17401 ctgcgccggc gcggcgcggc cgccgtcgac cccgccccgg acgccccgcc gctggagatc
    17461 cgcgacctcg ccaagaccta ccgcggcggg ttcagcgccg tgcggggcgt gtccttccgt
    17521 gtcgagcgcg ggcaggtgct gggcctgctc ggacccaacg gcgccggcaa gaccaccgtc
    17581 ctgcgcatgc tgatgggcct catccgcccg accgcgggca cgatgaccgc gttcggcgag
    17641 cccgtcgggc ccggcgcccc cgtgctcgcc cggatcgggg ccttcgtcga ggggccgggc
    17701 ttcctgccgc acctgtccgg cgccgacaac ctgcgcctgt actgggccgc caccggccgc
    17761 cccaccgcgg aggcccacct cgacgaggcg ctggagatcg ccgggctcgg cgccagcgtg
    17821 cagcgccgcg tcggcgccta cagccagggc atgcgccagc gcctggccat cgcccaggcc
    17881 atgctcggcc tgcccgagct gctcgtgctc gacgagccga ccaacgggct cgacccgccc
    17941 cagatccacg ccatgcgcga ggtcctgcgc cgctacgccg cgggcgggcg caccgtgctg
    18001 gtgtcgagcc acctgctggc cgaggtcgag cagacgtgcg accacgtggt cgtcatgcac
    18061 cacggccagg tcgtcgccga cggctcggtc gaggacgtca tcgccggggg cggggccgcg
    18121 acgttcgccg tcgacgcgcc gtcccgggcg gccgacgtcc tcggcgcgct cgccggcgtc
    18181 cacgcggtgg aggtcgacgg ggagcaggtg cacgccgagc tcaacggcac cccgcgcgcg
    18241 tcggcggtgc gggcgctcgt cacggccggg gtcgacgtcg cgtcggccgg gccgcggcgc
    18301 cgcctcgagg acgcgttcct gcagctcgtc ggagaggacg gcccgtcgtg accacgcccg
    18361 gaccgagcac gcccggaccc agcacccgca agggcaccgt cggcgccctc gccgccgggc
    18421 cgccgcccgc ggcctaccgg cccggctcga ccctcccgct gcgcgtcgag ctggtgcgcc
    18481 agctccggcg gcgccgcacg caggtgacgt tcgggctggt cgcggcactg ccggtgatcc
    18541 tgtggatcgc gttctcgctg gcgcccgacg gcccgcccac cggctcgctc aacctcgtcg
    18601 acctcgccca gggcagcggc acgaacttcg ccgtgttcgc gctgttcgcc tcggccgggt
    18661 tcctgctcgt cgtcgtggtc gcgctgttct tcggcgacac ggtggccgcg gaggcgtcct
    18721 ggtcgagcct gcgctacctg ctcgccgcgc cgatcccgcg gacgcggctg ctgcggcaga
    18781 aggcggtcgt cgcggccggg ctctcgctcg ccgcgatcct caccctgccg ctggtggcgc
    18841 tgctcgtggg cggcctggcc tacggcgccg gcaacctggt cagccccacc ggcgagtccc
    18901 tgacgttcgc ggcgggcgcc ggtcgggtcc tgctcggcgc gctgtacgtg gccgtgcagc
    18961 tgagctgggt ggcggcgctg gcgctgctgc tgtcggtgtc caccgacgcc ccgctcggtg
    19021 ccgtcggcgg ggcggtgatg gcgtcgatcg tcagccagat cctcaaccag atcaccgcgc
    19081 tggaggacct gcgcgacttc ctgcccaccc gcttctcgac ggcgtggtcg gacctgctcg
    19141 ccaccgacgt cgactgggac gccatgaccc gcggcgtgtt ctcctcgctg acctgggcac
    19201 tcgtgctcgg agcggccgcc gtgtaccggt tcggacgcaa ggacgtcacg agctgacgtc
    19261 ggtgtcccgc ccggtgtgtg gtcggtcacc ggttgtgggt acacccccgc acggcccgtc
    19321 atcgacgggc gtgacgaggg agccccagat gacgtccagc accgaccgcg gaccgggagc
    19381 ggccgactac ggccggaccc ccgatcacgg ccccgcaccc cacgaccggg tcggcgacca
    19441 ccgcgccccc gaccaccggg accccgaccc gcggggcacc gacccccgcg gcgtcgaccc
    19501 ccgcggcacc gatccccgcg acaacgaccc ccgcggtgtg gaccagcgcg gggtcgacca
    19561 gcgccccccg ggcacctacg ccgccggcgg cggccacgcc gacgccccga cggtcgcgac
    19621 cgggaccgcc ggcggcaccg ccctcacccc ccgccagcag cgccgcgccg cgcgcaccga
    19681 gcagcgccgc cagttcggcg gcatcaagtg ggggtcggcg ttcttcggct ggctcaccgc
    19741 gctgggcacc gcggtgctgc tcagcggcat cgtggcgggc gtcaccgagg gctacggcct
    19801 gacgaccgcc cccggcggcc cgccggaggg gatcgtcgcc gcgatcgtcg tggcggtcgt
    19861 gctgttcctc gcctacttct gcggcgggta cgtcgccggc cgcatggccc gcttcgacgg
    19921 ggcccgccag ggcgtcgcgg tgtggatctg ggccgtgctc gtcgccgtcg cggtgacggt
    19981 gctcatcgcc gtgtccggca cgcccgtcga cctcaccccg gtcgccgcgc tcgtcggcgg
    20041 cgtcgtcgac ccgtccgcgt tcaccccggc cgccatcggc gcgctggccg ccgccctcgt
    20101 ggtcggcctg gtcggcgccg tcctcggggg cctcgcgggg atgcggttcc accgccgcgt
    20161 cgaccgcgcc gtgccaccgg tcccgaccgc aacgccctga ggcggggccg gtgaggtggc
    20221 cggcgccgtg accccgggtg tgcccagcag gacacccccg acgatcacgg tgccggccac
    20281 cagttcgacc agcgagggcc gctcccccag caccacggcg gccagcccca tcccgacgac
    20341 cggcaccagc aacgagtacg gcgcgacgac gccggccggg tgccgcccca tgagccacgt
    20401 ccagatcccg gagccgagga cggtcgcggg cacgacgagg taggccagcg cgagcagccc
    20461 gggcaccccg gacgggccgg ccgcggccac cagcgcgtcg agccccgcct gcgggccctc
    20521 cgtcagccac gacatcgcga gcagcggcac cggcggcacc accgacatcc acagcgtcag
    20581 gtgcagcggg ttcggcgcgt gcgcgagccg gttggcgagg ttgccgaacg cccagcccag
    20641 cgccccgagc agggtgagca gcaccggcag gaccgccgcg gtctgcgccc gcgccaccac
    20701 gatcgcggcg agcccgagca cggccagccc gatcccgacg ccctggcgca cggcgagccg
    20761 ctcgcgcagc agcagcgccc ccagcagcac cgtgaacggc gccgacgcct gcagcaccag
    20821 cgacgcgagg ccgggcggca tcccgatgtc catcgcgacg aacaggccga tgaactgcac
    20881 ggtcccgaac cccagcccgt agccgagcag ccagcgcagc ggcacctgcg ggcgcggcac
    20941 gagcagcacc gtcggcaccg cgatcagcgc gaaccgcagc gcggccagga acagcggggg
    21001 gaagtgctcg agcccgacgt ggatcgcgag gaagttgccg ccccacaggg cggcgacgag
    21061 gacggcgagc aggcggtcgc ggaggggcac gcctccaccc tgcgggccgc cgtccctcca
    21121 gaccagcgaa tcgttctgca gggatgcttt agcctggctt catggacgtc cagcggctgc
    21181 gggtgctgcg cgagctcgcc gaccgcgggt cggtcaccgc cgtcgccgcc gccctgtcgt
    21241 tcacgccctc ggcgatctcg cagcagctca gggcgctggc cgaggaggtc ggcacggcgc
    21301 tgaccgagcc cgccgggcgc ggcctgcgtc tcaccgacgc cgggcgggtg ctcgccgccg
    21361 aggccgagga ggtgctcgcc gcgctcgccc gcgccgaggc ggccgtcgag gggctgcgga
    21421 cgacgccgcg cgggctggtg cgcgtggcgc tgttcccgtc ggccgcgcgg atgatgctgg
    21481 ccggggtgct ggcccggctc gacgccgcgc cgggcgtcga ggtggcgtgc cgcgacgtcg
    21541 acatgagccc ggccgccgtc gtcgccctca ccgccgactt cgacgtcgtc gtgacccacc
    21601 gcgacgagca cgggcccggc accgcgcccg gccggcacgt cgtgccgctg ctgcgcgagc
    21661 cgctcgacgt cgtgctcccg cccgggcacc ggctcgcgcg ccggcgccgg ctgcgcctcg
    21721 acgagctggc cggcgagtcg tggatcagcg tggaggtggg ctggcccgtc gacgacgtgc
    21781 tgcgctcgct cgcggtgcgc accggcaccg cgccgcgggt cgtgcaacgg atcaacgact
    21841 tctcggtcac cgaggagctc gtcgcggccg ggcgcgggat cgcgctgctg ccccgctact
    21901 ccaccgacga ccgcggcggg cggcggctgg tccgccgccc gctggccggg gtgcgggccg
    21961 cccggctggt ggaggcggtg ctgcggccca gcgcggccgc ccgcccggcc gtgcggacgg
    22021 tgctcgacgc gctcgtggcg gaggcggccg cgatcacctc gcgggccggc tgacg
//
