LOCUS       NZ_CP053564            27446 bp    DNA     circular CON 29-MAR-2024
DEFINITION  Pseudonocardia broussonetiae strain Gen 01 chromosome, complete
            genome.
ACCESSION   NZ_CP053564
VERSION     NZ_CP053564.1
KEYWORDS    RefSeq.
SOURCE      Pseudonocardia broussonetiae
  ORGANISM  Pseudonocardia broussonetiae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Pseudonocardia.
REFERENCE   1  (bases 1 to 7177725)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-MAY-2020) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013155125.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:16:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,087
            CDSs (total)                      :: 7,032
            Genes (coding)                    :: 6,962
            CDSs (with protein)               :: 6,962
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 70
            CDSs (without protein)            :: 70
            Pseudo Genes (ambiguous residues) :: 0 of 70
            Pseudo Genes (frameshifted)       :: 19 of 70
            Pseudo Genes (incomplete)         :: 48 of 70
            Pseudo Genes (internal stop)      :: 6 of 70
            Pseudo Genes (multiple problems)  :: 3 of 70
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:38:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3096857
            Orig. end                         :: 3124303
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053564.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27446
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="7"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..27446
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27446
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17446](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17446)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(704..1534)
                     /locus_tag="HOP40_RS15430"
                     /old_locus_tag="HOP40_15430"
     CDS             complement(704..1534)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157578.1"
                     /locus_tag="HOP40_RS15430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15430"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_240157696.1"
                     /transl_table=11
                     /translation="MGTVIDRARRVGGAALDVVERTLTAAGLGESPEKLGADARRYWEQ
                     PDGDRWRADSHWRDASVFAGTDLWSETGRRHLDLLRRMARVVEHPGPRGTVLEWGCGGG
                     ANAVHLAPEATAFVGVDLSAATLEECGRQVAAVTATPFRPVLIDPAEPEAAVAALRGTV
                     DVFTCFYVFELIVSQEYGARLLRIAADLLTDDGLALVQIKYDTGSFGTRPRRRNYRSRL
                     ASMTTYRIDEFWELAHDCGLVPHAVHLVPRNELDERYAYFLLTRAGGPRAEAAR"
     gene            complement(1563..2828)
                     /locus_tag="HOP40_RS15435"
                     /old_locus_tag="HOP40_15435"
     CDS             complement(1563..2828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986472.1"
                     /locus_tag="HOP40_RS15435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15435"
                     /product="polysaccharide pyruvyl transferase family
                     protein"
                     /protein_id="WP_172159179.1"
                     /transl_table=11
                     /translation="MTSRDTAHRDGPPRVGLFGLLGGGNIGNDGSMEAVLAHLRAERPD
                     AVLDCFCSGPEQVTARYGVPATPMQQWASYRLERRGPAAAVLKGVGKVVDAGRTLAWVR
                     RHDAVVVPGAGVLEATLPVRPWGFPYALFLLCLSGRLVGTRVALLDVGAEVIDSPATRL
                     LVRTAARLAHHRSFRDAHSRRVMGDMGVDTSGDEVGADLTFALPPVARPPEEPTGIVGV
                     GLMAWSGGSGDRRRAGEIHDAYLAAMTEFVGRLVDEGRRVRLLGGDAVDDAVAARLLDA
                     VRAARSGHAPLSVEADPVRSLDDLERAMHDVDVVVATRYHNVVAALRLGKPVLALSYAP
                     KTDAVMAEMGLAGFCHPARFPDADRLAAQFAELESRRAELGGVVAARAAVVVARLRRQL
                     SGLCGELLGERPPAAPVVGSAA"
     gene            complement(2825..4117)
                     /locus_tag="HOP40_RS15440"
                     /old_locus_tag="HOP40_15440"
     CDS             complement(2825..4117)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331012.1"
                     /locus_tag="HOP40_RS15440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15440"
                     /product="hypothetical protein"
                     /protein_id="WP_172159181.1"
                     /transl_table=11
                     /translation="MAVPARTAPAADRSRLLRAARRIGWGIADQGVSSLTNFALGIVVA
                     RALDPAGFGVFGLAWVTYGVVLNVSRGLCSDPFTVRFSAADPADRARAVARMTGCTLLV
                     GTVAGAVTAAVGAGLGDRLGAAFVALGLVLPGILLQDAWRFAFFAAGTGRRAFVNDVAW
                     AVALVPALAIASARPSVFAFVLAWGLSGGLAGLLGCLQAGIRPRPHLSLQWVREQRDLG
                     PRYLVENVSLSGAAQLRLYGLGAVAGLAAVGAIRGGELLIGPFLALLMGISVISVPEAT
                     RVRRAAPHRLVHFCLLLGAVQALAAAVWGAFLLVLPDAWGRALLGDVWPAAAVLIVPMT
                     LTVMGSSLSSGAMTGLRSLGAARRSLRAQLVAAAAYAVLGIAGAVLGGAPGSAWGLVAA
                     TSLAAAVWWSQLRAGLRDPAALAPPPTGRTP"
     gene            complement(4199..5767)
                     /locus_tag="HOP40_RS15445"
                     /old_locus_tag="HOP40_15445"
     CDS             complement(4199..5767)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152292.1"
                     /locus_tag="HOP40_RS15445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15445"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_172159183.1"
                     /transl_table=11
                     /translation="MSHTTPTGRRRRGAALASAVAGLVLITACQVAPPAAPGGGAEGGP
                     TGAGPGLPTGPVGAVCDNTVPGPAEPPPGAVVVRAGVVGDLRAQVDASPPGAVFWLEPG
                     THTLTPDQYASITPRDGDTFLGAPGAVLDGRGVNQYAFVSTAVDVTVAHLVVTGFVPPA
                     DQGVVNHDSGDGWVIEHNTIQGNKGAGMMAGDRQVVRGNCLRANGQYGMNAYQPGNGIT
                     GLLVEGNEIVGNNTDDWEARVEGCGCTGGVKFWAVNGADVRGNWVHDNRGPGLWGDTNN
                     NDFLVEGNVIEDNDGEALFYETSYNLVFRDNVVRRNAIVSGKTFAQDTDDFPVGSVYLS
                     ESGGEPRVPARTDRIEITGNAFEDNWSGITLWENADRFCNSAANTSTGNCTLLVPDVTA
                     CSQPAIASEPLYSDCRWKTQRVDIHGNTFTADPAVTGCAPGYADRMAVLSNVGTYPDWS
                     PYQGDVVQQAIVRDQDVQWFDNAYVGSWTFLVGSTGRSVPVTEWQAGETAQDDGSTFSP
                     GPGGC"
     gene            5876..7045
                     /locus_tag="HOP40_RS15450"
                     /old_locus_tag="HOP40_15450"
     CDS             5876..7045
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="HOP40_RS15450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15450"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_172159186.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 2e-39, bitscore:
                     134.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARMLCGAGEYPAGLAAVAAHRLPEPAHALPARPPSDDAFDALVR
                     GAAAHRVTGLLAAAVREGALPTTAEQARRAAAAHRAGQLRVLALEQQLLAVTALLAGHG
                     LGVRVLKGAALAHLDHPDPALRSFGDLDLLVRPAEIDRVVAVLSAAGFRRTLAEPRPGF
                     DRRFDKGLTMVPDAGYELDLHRTFVLGPWGRLVDLDALWSGPGQEFTVAGRPLRALDRP
                     HRFLHACFHAALGDWPLRLGSLRDVAELLRGLRSPGGADDTARVRAAAAGWGVEAVVTA
                     AVADAHRLLGGPDDALTGWARGFVPSRRDERWLALHTRADKTFAAQALATVPVLPRWRD
                     RAAYLYALALPQRGYTAGRHRTPAARLAYAVAQVRAGRSRRGARDEPGG"
     gene            7096..8874
                     /locus_tag="HOP40_RS15455"
                     /old_locus_tag="HOP40_15455"
     CDS             7096..8874
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417453.1"
                     /locus_tag="HOP40_RS15455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15455"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_172159188.1"
                     /transl_table=11
                     /translation="MRATGRARSVAAAPRLVVAAAREVRRADARGTAVACALQLVGAVA
                     ALGVVAAGKLTLDALLQPATADVGIGPALLALALATALSGSAGSLQRQQQRLLGERVSL
                     RVWDRLLDTTTRVDLATYESAGFATALERVQQNALTRPFLVTTSLLGLGGSVLGVVTMS
                     AVLIGVEPLLVPVLLAAGLPAVLLSRWAGATEFAFARRITAAHRRQVYLRELLSTRPYA
                     AEMRAFGTAGVLRGRYDALGAGVVGALRGQVRRRQWIGLLTTLGVGLALAGALLAIVEL
                     VRVGRIDLAEAGAAAIAVRLLSGQLAVVFGSIGELLESVPFLDDLEEFVARAPRASEPG
                     RALPLTDRIALRGVGFRYPDQARPALDGVDLEVRAGEVVALVGENGSGKTTLAKIVAGL
                     LDPAPGVREWDGEEVPAADVRASVGVVLQDFVRYQMTLRHNIELGDPERPADAAAVQAA
                     AERARLLAAADELPDGLDTMLGRDLDEGTDLSGGQWQRVALARALYRDAPVVVLDEPAA
                     ALDPRAEHALFRDVRAVLDGRAALLVSHRFSSTRLADRIYVLEAGRVVECGTHDELMAR
                     AGSYAELYTLQSSAYG"
     gene            9007..9997
                     /locus_tag="HOP40_RS15460"
                     /old_locus_tag="HOP40_15460"
                     /pseudo=""
     CDS             9007..9997
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007298571.1"
                     /locus_tag="HOP40_RS15460"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15460"
                     /product="IS481 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHANAALTPTARLRLGKLVVEQDWPVARAAERFQVSWPTAKRWAD
                     RYACEGEAGMQDRSSRPHHSPLATPAPAVRKIVHLRWKQRLGPVGIAAILGLSTSTVHR
                     ILTSCRINRLSHLDRATRGTGAPLRTPPPRRPGPRGCEEAGQHPRRRRMALRRTSPRQA
                     SSSRDPGQAAQPPPPAQDGHRLPAHRPRRPLPRRLHRDMRRRNRHHRGRGATPGSGLVR
                     RPPHHRPSGPDRQRSLLPLTPVARGLRRARDPPPPHPPLPPADQRQGRTVSPDAGRGVG
                     VPPALRQRNPPPQSPTRLDSRVQPSPTPHRLRRTPTDHQVDQPVRSVQL"
     gene            complement(10001..10270)
                     /locus_tag="HOP40_RS15465"
                     /old_locus_tag="HOP40_15465"
     CDS             complement(10001..10270)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986476.1"
                     /locus_tag="HOP40_RS15465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15465"
                     /product="PqqD family protein"
                     /protein_id="WP_240157697.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.4e-18,
                     bitscore: 64.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-14, bitscore: 52.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDSRGMRMRAGDYSARTIGNETIVLSLPTSRYFTVTGVGTRLFE
                     LLASETTVDEMVETVVAEYEVDAVTARRDVERFVGRLREVQLLG"
     aSDomain        complement(10007..10240)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HOP40_RS15465_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.40E-20"
                     /identifier="RREFam002.1"
                     /label="HOP40_RS15465"
                     /locus_tag="HOP40_RS15465"
                     /protein_end="88"
                     /protein_start="10"
                     /score="64.1"
                     /tool="antismash"
                     /translation="AGDYSARTIGNETIVLSLPTSRYFTVTGVGTRLFELLASETTVDE
                     MVETVVAEYEVDAVTARRDVERFVGRLREVQLL"
     gene            complement(10293..11597)
                     /locus_tag="HOP40_RS15470"
                     /old_locus_tag="HOP40_15470"
     CDS             complement(10293..11597)
                     /EC_number="5.4.3.8"
                     /NRPS_PKS="Domain: Aminotran_3 (36-335). E-value: 4.6e-45.
                     Score: 146.0. Matches aSDomain:
                     nrpspksdomains_HOP40_RS15470_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643146.1"
                     /locus_tag="HOP40_RS15470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15470"
                     /product="glutamate-1-semialdehyde 2,1-aminomutase"
                     /protein_id="WP_275691370.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.8e-39, bitscore:
                     134.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRSAEIAARLHRMVPGGSHTYAKGDDQYPEDMAPVISHGRGAHV
                     WDVDGNAYIEYGSGLRSVGLGHAHPRVVEAVRREVGRGTNFVRPSAIEAEAAQEFLETV
                     PTAEMVKFAKNGSDATTAAVRLARAATGRPLVAICRDQPFFSTDDWFIGTTAMSAGIPA
                     VTTDLTVTFPYGDLDAVAEVLELHAGRVACLVLEAATAVEPPPGYLQGLRALADRHGCV
                     LVLDEMITGFRWSEAGAQGVYGVTPDLSTFGKALGNGFAVSALAGRRELMELGGLRDER
                     ERVFLLSTTHGAETHALAAAIAVMRTYREEGVVARMHALGDRLAAGVRAVAAAAGVGEH
                     VLVRGRASNLVFATLDADLRPSQAYRTLFLRQLLAGGVIGPSFVVSSALSDDDVDRTVE
                     VVARACAVYRRALDVGDPAPWSGGRPVRPVFRPFA"
     aSDomain        complement(10593..11489)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HOP40_RS15470_Aminotran_3.1"
                     /evalue="4.60E-45"
                     /label="HOP40_RS15470_Aminotran_3.1"
                     /locus_tag="HOP40_RS15470"
                     /protein_end="335"
                     /protein_start="36"
                     /score="146.0"
                     /tool="antismash"
                     /translation="ISHGRGAHVWDVDGNAYIEYGSGLRSVGLGHAHPRVVEAVRREVG
                     RGTNFVRPSAIEAEAAQEFLETVPTAEMVKFAKNGSDATTAAVRLARAATGRPLVAICR
                     DQPFFSTDDWFIGTTAMSAGIPAVTTDLTVTFPYGDLDAVAEVLELHAGRVACLVLEAA
                     TAVEPPPGYLQGLRALADRHGCVLVLDEMITGFRWSEAGAQGVYGVTPDLSTFGKALGN
                     GFAVSALAGRRELMELGGLRDERERVFLLSTTHGAETHALAAAIAVMRTYREEGVVARM
                     HALGDRLAAGVRAVAAAA"
     gene            complement(11639..12295)
                     /locus_tag="HOP40_RS15475"
                     /old_locus_tag="HOP40_15475"
     CDS             complement(11639..12295)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013718.4"
                     /locus_tag="HOP40_RS15475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15475"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_172159189.1"
                     /transl_table=11
                     /translation="MRPARTGRSAADATAALCALVLLGLGLAVLGGTAPWAVDRAAAAA
                     TAGLTASSYDLLLAVDLVGEPVVAVGLAVLIALACLLCGRARLAAVAPLALALTAVAVA
                     SLKPLIGRTIHGPENLAYPSGHTATAAVLALVLLLLLVDLVRPGRLAAAALVVTGTVVA
                     AGVMAVAQVALSAHYATDTLGGLCLAVVTVTVTVRLVAAVPARTAVPAAPRGDPP"
     gene            complement(12297..13121)
                     /locus_tag="HOP40_RS15480"
                     /old_locus_tag="HOP40_15480"
     CDS             complement(12297..13121)
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016699872.1"
                     /locus_tag="HOP40_RS15480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15480"
                     /product="sugar phosphate nucleotidyltransferase"
                     /protein_id="WP_172159190.1"
                     /transl_table=11
                     /translation="MKVVLFCGGYGMRMRDGTSDLPKPMHTVGPRPLIWHVMRYYAHFG
                     HTDFVLCLGYGAEHVKDYFLHYSETASNDFRLRGGRIEMLGSDIQDWTITFVHTGLDSA
                     IGERLRRVREHVEGEEMFLANYADVLTDLPLADMIDRFKASEAVGALLAVPPQSAFHCV
                     DLGDDDRISAISTLQQLPLWENGGYFVLRPEVFDYLPPGGDLVADACAALAREGRMLAH
                     RHRGFWQPADTVKERNALEIAYQTGHRPWMLWEHHAAEEALPPVALAVPVPR"
     misc_feature    13206..13219
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.57"
                     /tool="antismash"
     gene            13334..14575
                     /locus_tag="HOP40_RS15485"
                     /old_locus_tag="HOP40_15485"
     CDS             13334..14575
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420735.1"
                     /locus_tag="HOP40_RS15485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15485"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_172168414.1"
                     /transl_table=11
                     /translation="MVPATPSCRLCGSPDLRSFLDLGATPPCELFLTAEAAGAAEVTYP
                     LHVLVCAGCLLVQLPPLITPEETFTEYAYFSSFSTSWVRHAAAFVDGAVERLGLGPDSF
                     VVEVASNDGYLLQHLAPHGVRCLGIEPSANVGDAARERGVPTVTCFLTPETGPRVRAQH
                     GPADLVVANNVYAHIPDVLGFTRGLRSLVADDGWVSIEVQHLLTLVQRTQFDTVYHEHF
                     QYYTLLTGQRALAEGGLALVDVELLDTHGGSIRMWARPAAAVGPDDVSDRVRDVLAAEA
                     AAGLHTVEGYDGFATAVSRVRDDLVEFLIEARRDGRTVVGYGAPGKGNTLLNFCGIRPD
                     LLPYTVDRNPYKHGRLTPGTRIPVCPVERIAHDRPDYVLVLPWNLRDELVEQLSYVREW
                     GGRLVFPIPRLEIV"
     gene            complement(14515..15711)
                     /locus_tag="HOP40_RS15490"
                     /old_locus_tag="HOP40_15490"
     CDS             complement(14515..15711)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986483.1"
                     /locus_tag="HOP40_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15490"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_240157698.1"
                     /sec_met_domain="Asn_synthase (E-value: 4.8e-18, bitscore:
                     64.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALHRMEPLEIASGWLADSPCPPLPAPPGPAPRRLLDALLVPLLA
                     RPPCLVAFSGGRDSSALLAAAVAAAHREGLPPPVAITLTYPDAPGAQESDWQRRVLDHL
                     GVTERVVLVVHDEHDAVGPVAAPLLRRHGVIWPPNVAPTWRMMDRARGGSLLTGEGGDE
                     VFGVKRITALTKLLHTRTRADRRLVPLAAQALAPAAFRRRTARRESYRPPWLRADAWRE
                     VLRRHLDDVAAEELHAGRQTWQLASHRGSRIGYATLRALGEEIGVRYVQPFVDPGFVAA
                     TAAEAGFWGWTGRTTAMRHLFDDLLPRAVLERATKATFNGAVFAAHTRDFARGWTGDGV
                     DHDLVDAAVLREHWLSPLPHAPSMALLHQAWLAEGGTTGQTISNRGIGNTSLPPHSRT"
     gene            complement(15774..15914)
                     /locus_tag="HOP40_RS15495"
                     /old_locus_tag="HOP40_15495"
     CDS             complement(15774..15914)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HOP40_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HOP40_15495"
                     /product="hypothetical protein"
                     /protein_id="WP_172159191.1"
                     /transl_table=11
                     /translation="MRQPYEPPEIELLGSVIEETQGFRFTAQQDSIFGVNVPFGGSPVH
                     S"
     gene            complement(16011..16997)
                     /locus_tag="HOP40_RS15500"
                     /old_locus_tag="HOP40_15500"
     CDS             complement(16011..16997)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986479.1"
                     /locus_tag="HOP40_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15500"
                     /product="hypothetical protein"
                     /protein_id="WP_172159192.1"
                     /transl_table=11
                     /translation="MTLHRYRAHGLRVRSTVALALPADAVTRAGRSGGRPDLVLRAGLR
                     RPVPCADPPGTLLAALDRPGGGRYYCFTRTADAVVLRYPGLCDFVGDAALRQVTVHLDP
                     AADAGLVPVLAAGALLAVHLTLRHALVLHASAVDVDGRALAFVGASGTGKSTLAAALAG
                     AGHALVSDDVLRVEPGDVPRVHPGSTEARLRPAAQALADDAPPGAVRATADGRLALALP
                     VRAGAPLPLAACVLPAPNRTASEVAVRPLSPAQALVRLVQFPRVVGWREPAAAAAQFQA
                     LADLVQVVPVVQASIPWGPPFPPGVLAELVEAVTGPARSRRDRTRGA"
     gene            complement(16994..17446)
                     /locus_tag="HOP40_RS15505"
                     /old_locus_tag="HOP40_15505"
     CDS             complement(16994..17446)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986478.1"
                     /locus_tag="HOP40_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15505"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_172159193.1"
                     /sec_met_domain="PF13471 (E-value: 1.9e-13, bitscore: 49.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARRWALGAVEVLRALGPMVAVEVLLRTTDLPTTCRRLGVAHDL
                     TAPAAPARATTDPISRAGPTAVLPRRTRRVVRACALVVAHWPAGDTCLRRCLLTGHRLR
                     GLGPVLRIGVRRTGDGRFSAHSWLEVDGRPLDPAAGAFAALGAARP"
     gene            17719..18042
                     /locus_tag="HOP40_RS15510"
                     /old_locus_tag="HOP40_15510"
     CDS             17719..18042
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HOP40_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HOP40_15510"
                     /product="hypothetical protein"
                     /protein_id="WP_172159194.1"
                     /transl_table=11
                     /translation="MAVLGWVMGLGTLWIACAWVVAVVLGGVILRSGTVRTAPSAALRA
                     GVPSSGALSSGALSSALASVPAAARTAGTPTAAEIVPQPRTALPRRDPRAGCVRTGRPA
                     GRD"
     misc_feature    18296..18311
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            18512..19927
                     /locus_tag="HOP40_RS15515"
                     /old_locus_tag="HOP40_15515"
     CDS             18512..19927
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227151.1"
                     /locus_tag="HOP40_RS15515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15515"
                     /product="sugar transferase"
                     /protein_id="WP_240157699.1"
                     /sec_met_domain="Bac_transf (E-value: 5.1e-68, bitscore:
                     226.8, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAPRTSWEGRYTALVVLADVLVVGAGTLLGGWISSTFLGVPAVP
                     NAWGLAGIAGLLTLICLWVWRAWEPRTLGQGSEEFSSVLRGTITSLVLLGLFGLAFELS
                     SVRPWAFAFIPVIGIAIAAARYVMRRALHRRRFTGQCMHRVLAVGTPQSIAELVVRTRD
                     NPHFGWQVAGACTASGYGLDGDTTIAGVPVVGDLEALHRVVDAGHYRVVAVTPTPDWSP
                     RRLQRLSWEFENSQAEIVVDPGLLEVAGPRLHVKPVDGLPLLRLTEPRFSGIAKVMKGC
                     FDRFCAVVLLFLLLPLLIGVAIAVKLDGGPVFFRQIRVGRHGETFRMVKFRSMVVDAEK
                     LRADLVTMNEGAGPLFKMRRDPRVTAVGQWLRRYSLDELPQLFNVLGGSMSLVGPRPPL
                     PAEVEGYSTETHRRLHVRPGLTGLWQVSGRSDLSWDESIRLDLRYVENWSLALDALILW
                     KTVGAVLRGDGAY"
     gene            complement(19921..21255)
                     /locus_tag="HOP40_RS15520"
                     /old_locus_tag="HOP40_15520"
     CDS             complement(19921..21255)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672360.1"
                     /locus_tag="HOP40_RS15520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15520"
                     /product="UDP-glucose/GDP-mannose dehydrogenase family
                     protein"
                     /protein_id="WP_172159196.1"
                     /transl_table=11
                     /translation="MFARRITVVGAGYVGLTTGACLAALGHWVTCADPDAALIARLRAG
                     DEPLREPGLPALVDEGLSAGRLSLVAGAAAALSTPRGAAEVVILCVPTPVGAGGVADLT
                     ALQAAVEEVGPHLAPGCVLVVKSTVPVGTAPRVRELLGRDDVPVVSNPEFLREGTAVHD
                     FRHPDRIVVGSDSQDAAERVAALYSRLGAPTVLTDAASAELVKYAANAFLALKLSYVNA
                     LAELCERVGADVGDVTEGIGHDKRIGQAFLSPGPGWGGATLPKDTHALLEAADAADFEF
                     RIVRAAIDTNTRQRRRMVDKVRLAVTGSRTGSLSRCRIGLLGLTFKAGTDDLRDSPALA
                     VAALLRQAGAELVAHDPAVAPGRADPELAGIEVVATAEAAARDVEALVVLTEWPQFRTL
                     DWPALAGLTVRPIVVDTRNLLDPDVLRRAGFTCHPLGRRVRTVTQ"
     gene            21440..22681
                     /locus_tag="HOP40_RS15525"
                     /old_locus_tag="HOP40_15525"
     CDS             21440..22681
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014237.4"
                     /locus_tag="HOP40_RS15525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15525"
                     /product="glycosyl hydrolase"
                     /protein_id="WP_172159198.1"
                     /transl_table=11
                     /translation="MRAPEAPPIEPRHRRSAAPAPRRGFGGRWLPVGVVMAVAAVCAGV
                     YVVDQLTVPPEIAQPDLLSLIPPTPDVPPVLAAPAAVDSAPSAEPEATGPATEEAGSGA
                     GSGEAAAEGSGEPAATGTTRRRVTGNAPGGLPWRSGLVIGTQSEVDRWESFRGRPIDVV
                     HGFSDRSSWEEIESASWILSAWGDSPHALVISQPFWPEGSGGSLSECASGAYDANWARY
                     GTALSNAGRTDAYTRLAWEFNGDWFEWSATDVTAWKQCYRQVVQAVRSTAPDARFEWNM
                     NAHGSQTSDGDAWKSYPGDDVVDVVGIDPYDHYPTSTTAAEFDEQCRDSEGLCSVIDFA
                     RAHGKGVGVTEWGVISSGIGDNPVYMEKMHETFLAGADVMEYETYFNESAFATTLDDGA
                     NPQSAEVYRSLWGG"
     gene            complement(23958..25103)
                     /locus_tag="HOP40_RS15530"
                     /old_locus_tag="HOP40_15530"
     CDS             complement(23958..25103)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013227.4"
                     /locus_tag="HOP40_RS15530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_15530"
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_172159200.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.1e-64,
                     bitscore: 216.2, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEHAPVPFLRPQLPPLTEVQRYFTLAEQARFYSNGGPCERLLRE
                     RLSDYLDGATCIPVNNATSGIIVAVLGAVHQAGTRGRGLVVTPAYTFVATAGSIEALGY
                     RPLFVDVDPDGWQMDPDALERALAEHGHDVAAVLATHTFGTPPPAGLQDRWAGACAARG
                     VPLVVDTAAAFGAVDEAGSRTGTATGTHVFSFHATKPFGVGEAGMISTRDPELARLLDG
                     IRQFGFAEGRVASLPGINAKMDELHAATALTVLDTYADVLAARRSTAEFYRQHLEPAGF
                     RFQTGSAGGTWQAGYLQAPDPAARDALLVAGREAQVGITAYYERPLHHHPAYAHALLES
                     ALPVSEALSASALALPMANDLTEVERARVVEVVLATVGAAA"
     gene            complement(25096..26073)
                     /locus_tag="HOP40_RS15535"
                     /old_locus_tag="HOP40_15535"
     CDS             complement(25096..26073)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HOP40_RS15535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HOP40_15535"
                     /product="hypothetical protein"
                     /protein_id="WP_172159202.1"
                     /transl_table=11
                     /translation="MTTATSRPLRVLHRSYGGDNAKPRPEYYSKLLALAALLRAADALD
                     VAPELVFINDGPMPDERLRVMERFGEVVPVRRGGSDTNSYREMLADENARTGEPDDLLW
                     LAEDDYLYVPDALRQLVAAAAALPADYFTLYGSRAVDVERSGRRPVIRPEPAAEGTGQY
                     VEVGDVAWYRAAATTSTFAITRRALAEDVRLLRHFALTGGAWDSATCKAIQGFAPFTGQ
                     RLRRDFLPFGEVPPAQWPKSVVRGALRVASIPVSVRRPQRRRALLGSDPELILHMEAPD
                     DPPRRLSTRTQKIDWAAVAAETAEWANDHGIPVVIPAPSGGSRG"
     misc_feature    complement(26092..26105)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.33"
                     /tool="antismash"
     misc_feature    complement(26884..26898)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.06"
                     /tool="antismash"
ORIGIN
        1 ctggaccggg ccgcgtgctc gcgccgcacg tagagccact cgggcacctg cacgaacggg
       61 ccgtgcagcg ccagctccgc gaccagcgtg cggtcggcgt tgtagaagct gtcgtagggc
      121 cggacgcggc gcagcaccga cgagcggatc accccgtagt cgtcgtcgcc gccgctgtcc
      181 cacagcaggc tgtgcagccg gtcggccggg cgcggggcgg cgctggccag ggggtaggtc
      241 agcggcgtcg tcacgccggt gtcctcgtcg agcacggccg tgtagcagtg cgcgagcacg
      301 gccccgggcg tcgcgtccag tgcggccacg cagcgggcca gcaggtccgg gtcgtacacg
      361 tcgtcgtccg cggcccactt gaacagctcc ccgcgcgaga gcgcgaacac cgcgttgtgg
      421 ttgccggcca gcccgatgtt gcgcggctgg cggacgtagc gcacgcgcgg gtcgcgctcg
      481 gcgaacccgc ggcagatggc ttcggtggcg tcggtcgacc cgttgtcgga gacgacgagc
      541 tcgaagtcgg tgaagctctg cccgagcagc ccgcccaggg cctcgggcag gtagcgctcg
      601 ccgttgtaga cgggcagacc gatgctcagc cgcggggtgc gggccgcggc cccggcctcc
      661 ggcggcgtcc gcgggagcgg gatctcgctc gtgcgctgct cggtcaccgg gcggcctccg
      721 cgcgggggcc gccggcccgg gtgagcagga agtaggcgta gcgctcgtcg agctcgttgc
      781 gcgggaccag gtgcacggcg tgcgggacga gcccgcagtc gtgcgccagc tcccagaact
      841 cgtcgatgcg gtaggtcgtc atgctggcca gccgcgaccg gtagttgcgc cgccggggcc
      901 gggtgccgaa ggaccccgtg tcgtacttga tctgcacgag cgccaggccg tcgtcggtga
      961 gcaggtcggc ggcgatccgc agcagccggg cgccgtactc ctgggagacg atgagctcga
     1021 agacgtagaa gcaggtgaac acgtcgacgg tgccgcgcag cgccgccacc gcggcctccg
     1081 gctccgcggg gtcgatcagc accgggcgga acggtgtcgc cgtgacggcg gcgacctgcc
     1141 gcccgcactc ctcgagcgtg gccgccgaca ggtcgacgcc gacgaacgcg gtggcctccg
     1201 gggcgaggtg cacggcgttg gcgccgccgc cgcagcccca ctccagcacg gtgccccgcg
     1261 gcccggggtg ctcgacgacg cgggccatcc gccgcaacag gtcgaggtgc cggcgcccgg
     1321 tctccgacca caggtcggtg cccgcgaaca cgctcgcgtc gcgccagtgg gagtcggcgc
     1381 gccaccggtc gccgtcgggc tgctcccagt agcgccgggc gtccgcgccg agcttctctg
     1441 gggactcgcc cagtccggcc gcggtgagcg tccgctcgac gacgtcgagc gcggcgccgc
     1501 ccacccggcg ggcccggtcg atcacggtgc ccatcccgtc ctcctcctgc tcctcgtgcg
     1561 gctcatgcgg cgctccccac gaccggtgcc gcgggcggac gctccccgag cagctccccg
     1621 cacaggccgg agagctggcg ccgcagccgg gcgaccacca cggccgcccg ggccgcgacg
     1681 accccgccca gctccgcgcg ccgggactcc agctccgcga actgcgcggc cagccggtcg
     1741 gcgtcgggga agcgggccgg gtggcagaac ccggcgaggc ccatctcggc catcaccgcg
     1801 tcggtcttgg gggcgtacga cagcgccagc acgggcttgc cgagccgcag cgccgcgacg
     1861 acgttgtggt agcgggtggc caccacgacg tcgacgtcgt gcatcgcgcg ctccaggtcg
     1921 tccagcgagc ggaccgggtc ggcctcgacg gacagcgggg cgtgaccgga ccgggcggcg
     1981 cggaccgcgt cgaggagccg ggcggcgacg gcgtcgtcga cggcgtcgcc gccgagcagc
     2041 cgcacgcgcc gcccctcgtc gacgagccgg ccgacgaact cggtcatcgc ggcgaggtag
     2101 gcgtcgtgga tctccccggc ccggcggcgg tcgccgctgc cgccgctcca cgccatgagt
     2161 ccgaccccca cgatcccggt cggctcctcc ggcggccgcg ccaccggagg cagggcgaac
     2221 gtgaggtcgg cgcccacctc gtcgccggag gtgtcgacac ccatgtcgcc catgacccgc
     2281 cgggagtgcg cgtcgcggaa ggagcggtgg tgggcgagcc gggcggccgt gcgcaccagc
     2341 agccgggtgg ccgggctgtc gatcacctcg gcgccgacgt cgagcagcgc gacccgggtg
     2401 ccgaccaggc gtcccgagag gcacagcagg aacagcgcgt acgggaagcc ccacgggcgc
     2461 accggcagcg tcgcctccag caccccggcg cccggaacga ccacggcgtc gtggcggcgc
     2521 acccaggcca gcgtccggcc cgcgtcgacg accttgccca cacccttgag cacggccgcc
     2581 gccgggccgc ggcgctccag ccggtaggac gcccactgct gcatcggcgt ggccggcacg
     2641 ccgtaccgcg cggtgacctg ttcggggccg ctgcagaagc agtcgagcac ggcgtcgggc
     2701 cgctccgccc gcaggtgcgc gagcacggcc tccatcgacc cgtcgttgcc gatgttgccg
     2761 ccgccgagca ggccgaacag cccgacgcgc gggggtccgt cgcggtgcgc ggtgtcgcgg
     2821 gacgtcatgg ggtcctcccg gtcgggggcg gcgcgagcgc ggccgggtcg cgcaggcccg
     2881 cgcggagctg ggaccaccac acggcggcgg ccagcgaggt ggcggcgacg aggccccagg
     2941 ccgagccggg ggcgccgccg aggaccgcgc ccgcgatgcc gagcacggcg taggccgcgg
     3001 cggccacgag ttgggcgcgc aggctgcgcc gcgccgcgcc gagggaccgc agcccggtca
     3061 tcgcgccgct ggagaggctc gagcccatca cggtgagcgt catcggcacg atcagcaccg
     3121 ccgccgcggg ccagacgtcg ccgagcagcg cgcggcccca ggcgtcgggc agcaccagca
     3181 ggaacgcccc ccacaccgcg gccgcgagcg cctgcaccgc gcccaggagc aggcagaagt
     3241 gcaccagccg gtgcggtgcg gcccggcgca cccgggtggc ctcgggcacc gagatcaccg
     3301 agatccccat gagcagggcg aggaacgggc cgatcagcag ctcgccgccg cggatcgcac
     3361 cgaccgcggc cagccccgcg accgccccga ggccgtagag ccgcagctgc gcggccccgc
     3421 tgaggctcac gttctccacg aggtagcgcg ggccgaggtc gcgctgctcg cggacccact
     3481 gcagggacag gtgcggccgg ggccggatcc cggcctgcag gcacccgagc agcccggcga
     3541 gcccgcccga gaggccccac gccagcacga acgcgaacac cgacggccgg gccgaggcga
     3601 tcgcgagggc cgggacgagc gccacggccc aggcgacgtc gttgacgaag gcgcgacgcc
     3661 cggtgccggc ggcgaagaag gcgaaccgcc aggcgtcctg cagcaggatc cccggcagca
     3721 ccaggcccag cgcgacgaac gccgccccga gccggtcgcc caggcctgcg ccgaccgcgg
     3781 cggtgaccgc acccgcgacg gtccccacga gcagcgtgca gcccgtcatc cgggcgacgg
     3841 cccgggcgcg gtcggccggg tcggcggcgc tgaaccgcac cgtgaacggg tcgctgcaca
     3901 ggccgcgcga gacgttgagg acgacgccgt aggtgaccca cgccagcccg aagacgccga
     3961 agcccgccgg gtcgagcgcc cgcgcgacga cgatgccgag cgcgaagttc gtcaggctgg
     4021 agacgccctg gtcggcgatg ccccagccga tgcggcgggc ggcccgcagg aggcgggacc
     4081 ggtcggccgc gggtgcggtg cgggcgggca cggccacttc cgatcccccc ggctccctcg
     4141 tggaacggcc ttgcggacgc gggtgatgtc gatcccgcgg gcgtgggtgt taccccgttc
     4201 agcagccccc ggggcccggg gagaacgtgc tgccgtcgtc ctgggcggtc tcccccgcct
     4261 gccactcggt gacgggcacc gagcggccgg tgctgcccac gaggaacgtc caggacccga
     4321 cgtaggcgtt gtcgaaccac tggacgtcct ggtcgcgcac gatcgcctgc tgcacgacgt
     4381 cgccctggta gggggaccag tcggggtagg tgccgacgtt ggacagcacg gccatccggt
     4441 cggcgtagcc cggcgcgcac ccggtgaccg ccgggtcggc ggtgaaggtg ttgccgtgga
     4501 tgtcgacgcg ctgggtcttc caccggcagt ccgagtacag cggttcgctg gcgatggcgg
     4561 gctgcgagca ggccgtgacg tcggggacga gcagggtgca gttgccggtg gaggtgttcg
     4621 cggcgctgtt gcagaaccgg tcggcgttct cccacagcgt gatgcccgac cagttgtcct
     4681 cgaacgcgtt gccggtgatc tcgatgcggt cggtgcgggc cgggacgcgc ggctccccgc
     4741 ccgactcgct caggtacacc gagccgaccg ggaagtcgtc ggtgtcctgc gcgaaggtct
     4801 tcccgctgac gatcgcgttg cggcgcacga cgttgtcgcg gaacacgagg ttgtagctcg
     4861 tctcgtagaa gagggcctcg ccgtcgttgt cctcgatgac gttgccctcg acgaggaagt
     4921 cgttgttgtt ggtgtcgccc cacagtccgg ggccgcggtt gtcgtgcacc cagttgccgc
     4981 ggacgtcggc cccgttcacg gcccagaact tgacgccccc ggtgcagccg cagccctcga
     5041 cccgcgcctc ccagtcgtcg gtgttgttgc cgacgatctc gttgccctcc acgaggagtc
     5101 cggtgatgcc gttgccgggc tggtaggcgt tcatcccgta ctggccgttg gcgcgcaggc
     5161 agttgccgcg caccacctgg cggtcccccg ccatcatccc ggcgcccttg ttcccctgga
     5221 tcgtgttgtg ctcgatgacc catccgtcgc ccgagtcgtg gttgaccact ccctggtcgg
     5281 cgggcggcac gaacccggtg acgacgaggt gcgccaccgt cacgtcgacg gcggtggaga
     5341 cgaaggcgta ctggttgacc ccgcgcccgt cgaggaccgc gccgggcgcg ccgaggaacg
     5401 tgtcgccgtc gcgcggggtg atcgacgcgt actggtcggg ggtcagggtg tgggtgccgg
     5461 gctcgagcca gaacaccgcg ccgggcggac tggcgtcgac ctgcgcgcgc aggtcgccga
     5521 cgaccccggc gcggaccacg accgcgcccg gcggcggttc cgcgggcccg gggacggtgt
     5581 tgtcgcagac cgcgccgacg ggtcccgtgg gcaggcccgg tccggcgccg gtggggccgc
     5641 cctccgcccc gccgcccggg gcggccggcg gcgcgacctg gcacgcggtg atcagcacga
     5701 ggccggccac cgccgacgcg agcgccgcgc cccggcggcg tcggccggtg ggcgtcgtgt
     5761 ggctcatcgt cggctcccgt ccacccggcc cgtccccgcg acgggccgcg cccgtggact
     5821 cgtccccgcg ccgggcgccg ttaccgccct acactcaccg gccggaggtc cggggatggc
     5881 gcgcatgctc tgcggtgcgg gggagtaccc ggccgggctg gcggcggtgg ccgcgcaccg
     5941 gctgcccgag ccggcgcacg cgctgccggc ccggccgccg tccgacgacg cgttcgacgc
     6001 gctggtgcgc ggggccgccg cccaccgggt cacgggtctg ctggcggcgg cggtgcgcga
     6061 gggcgcgctg cccaccacgg ccgagcaggc gcgccgcgcg gccgcggccc accgcgccgg
     6121 gcagctgcgg gtgctcgcgc tggagcagca gctcctcgcc gtgaccgcgc tgctggccgg
     6181 gcacgggctc ggcgtgcgcg tgctcaaggg cgccgcgctg gcccacctcg accaccccga
     6241 cccggccctg cggtcgttcg gcgacctgga cctgctcgtg cggcccgccg agatcgatcg
     6301 ggtcgtcgcc gtcctgtccg cggccggctt ccggcggacc ctggccgagc cgcgccccgg
     6361 gttcgaccgg cgcttcgaca agggcctgac gatggtgccc gacgcgggct acgagctgga
     6421 cctgcaccgg acgttcgtcc tgggcccgtg gggccggctc gtcgacctcg acgcgctgtg
     6481 gagcgggccc ggacaggagt tcaccgtcgc ggggcggccg ctgcgggcgc tcgaccgtcc
     6541 gcaccgcttc ctgcacgcct gcttccacgc cgcgctgggc gactggccgc tgcggctggg
     6601 ctcgctgcgc gacgtcgcgg agctgctgcg ggggctgcgg tcaccgggcg gcgccgacga
     6661 caccgcccgg gtgcgggccg ccgcggccgg ctggggcgtc gaggccgtcg tgacggccgc
     6721 ggtggccgac gcgcaccggc tgctcggtgg cccggacgac gcgctcacgg ggtgggcgcg
     6781 cgggttcgtg ccgagccgcc gcgacgagcg ctggctcgcc ctgcacaccc gggcggacaa
     6841 gacgttcgcg gcgcaggccc tcgccacggt gccggtgctg ccgcggtggc gcgaccgcgc
     6901 ggcctacctc tacgccctcg cgctcccgca gcgcggctac acggcgggcc gccaccgcac
     6961 gcccgccgcc cgcctggcgt acgccgtcgc gcaggtccgg gccggtcgct cccggcgcgg
     7021 ggcgcgcgac gagccgggcg gctgaccccg gtcacgacgc ggacccgggc cgacccgggc
     7081 ggctacgatc ttgcgatgcg cgcgacgggg agggcgaggt cggtggccgc cgcgccgcgc
     7141 ctggtcgtcg ccgcggcccg cgaggtgcgc cgggccgacg cccgcggcac cgccgtcgcc
     7201 tgcgccctgc agctggtcgg agccgtcgcg gcgctcggcg tcgtcgccgc gggcaagctc
     7261 accctcgatg ccctgctgca gccggcgacc gccgacgtcg ggatcggccc ggcgctgctg
     7321 gccctcgcgc tcgccaccgc cctgtccggt tcggccggct cgctgcagcg ccagcagcag
     7381 cggctgctcg gcgagcgggt gtcgctgcgc gtgtgggacc ggctgctcga caccaccacc
     7441 cgcgtcgacc tggccaccta cgagtccgcg gggttcgcca ccgcgctgga gcgggtgcag
     7501 cagaacgcgc tgacccgccc gttcctcgtc accacctcgc tcctgggcct gggcgggagc
     7561 gtgctgggcg tcgtcacgat gtcggccgtg ctgatcggcg tcgagccgct gctggtgccg
     7621 gtgctgctcg ccgccggtct gcccgcggtg ctgctgtcgc gctgggccgg ggccaccgag
     7681 ttcgccttcg cgcgccggat caccgccgcc caccgccgcc aggtgtacct gcgcgagctg
     7741 ctcagcaccc gcccctacgc cgccgagatg cgggcgttcg gcacggccgg cgtcctgcgc
     7801 gggcgctacg acgcgctcgg ggccggcgtc gtcggcgccc tgcgcgggca ggtgcggcgg
     7861 cgccagtgga tcgggctgct caccacgctc ggggtcggcc tcgcgctggc cggggcgctg
     7921 ctcgcgatcg tcgagctggt ccgggtcggg cgcatcgacc tggccgaggc cggggccgcg
     7981 gccatcgcgg tgcgcctgct cagcggccag ctcgccgtgg tgttcggctc gatcggcgag
     8041 ctgctggagt cggtgccgtt cctcgacgac ctggaggagt tcgtcgcccg cgccccgcgc
     8101 gcctccgagc ccgggcgggc gctgccgctc accgaccgga tcgcgctgcg cggcgtcggc
     8161 ttccggtacc ccgaccaggc gcggcccgcg ctcgacggcg tcgacctgga ggtccgggcg
     8221 ggcgaggtcg tcgcgctggt gggggagaac ggttcgggga agacgacgct ggcgaagatc
     8281 gtggccgggc tgctcgaccc cgcaccgggc gtgcgggagt gggacggcga ggaggtgccc
     8341 gccgccgacg tccgcgcgtc ggtcggggtc gtcctgcagg acttcgtgcg ctaccagatg
     8401 acgctgcgcc acaacatcga gctcggcgac cccgagcgcc ccgccgacgc cgccgcggtg
     8461 caggccgcgg cggagcgcgc gcgcctgctc gcggccgcgg acgagctgcc cgacgggctc
     8521 gacaccatgc tcgggcgcga cctcgacgag ggcaccgacc tgtccggcgg ccagtggcag
     8581 cgggtcgccc tggcccgggc gctctaccgc gacgcgccgg tggtcgtgct cgacgagccc
     8641 gcagcggccc tggacccccg cgccgagcac gccctgttcc gcgacgtccg cgcggtcctc
     8701 gacggtcgcg cggccctgct cgtgtcgcac cgcttctcca gcacccgcct cgccgaccgc
     8761 atctacgtgc tggaggcggg ccgggtcgtc gagtgcggca cccacgacga gctcatggcc
     8821 cgcgcgggga gctacgcgga gctctacacg ctccagtcgt cggcctacgg ctagctgtac
     8881 tgatcggaga cgttggtcga ggtcgtgtga cgacacggtc tgactgatct tgataggtga
     8941 ggaccccctg gggtggtgtg gagctgtctg acggcaccca caccacgacc ccaggaggtc
     9001 ctcaccgtgc acgctaacgc tgcgctgacc ccgaccgcac gactacgcct ggggaagctg
     9061 gtcgtcgagc aggactggcc cgtcgcccgg gccgcggaac ggttccaggt gtcctggccg
     9121 acggcgaaac gctgggccga ccgctacgcc tgcgagggcg aggccgggat gcaggaccgg
     9181 tcctcccgcc cgcaccactc gccgctggcg accccggccc cggcggtgcg caaaatcgtg
     9241 cacctgcgct ggaagcaacg cctgggcccg gtcgggatcg ccgcgatcct cgggctgtcg
     9301 acctccacgg tgcaccgcat cctgacctca tgccggatca accggctctc ccacctggat
     9361 cgggccaccc ggggaaccgg tgcgccgcta cgaacacccc caccccggcg acctggccca
     9421 cgtggatgtg aagaagctgg gcaacatccc cgacggcggc ggatggcgct tcgtcggacg
     9481 agcccaaggc aagcgtcatc gagccgcgac cccgggcaag ccgcgcaacc gccaccacca
     9541 gcccaagatg ggcaccggct acctgcacac cgtcctcgac gaccactccc gcgtcgccta
     9601 caccgagata tgcgacgacg aaaccgccac caccgcggtc gcggtgctac accgggcagt
     9661 ggcctggttc gccgcccgcc acatcaccgt ccgagcggtc ctgaccgaca acggagcctg
     9721 ctaccgctca cacctgtggc gcgaggcctg cgccgagctc gagatccgcc accgccgcac
     9781 ccgcccctac cgcccgcaga ccaacggcaa ggtcgaacgg tttcaccgga cgctggtcga
     9841 ggggtgggcg ttccgccggc tctacgccag cgaaacccac cgccgcaaag ccctacccgg
     9901 ctggattcac gagtacaacc atcaccgacc ccacaccgcc tgcggcggac acccaccgat
     9961 caccaggttg accaacctgt ccgatcagta cagctagcgc tcacccgagc agctgcacct
    10021 cgcggagccg gccgacgaac cgctccacgt cgcggcgcgc ggtcaccgcg tccacctcgt
    10081 actccgccac gacggtctcg accatctcgt ccacagtggt ctccgatgcg agcagctcga
    10141 acagccgcgt cccgacgccg gtcaccgtga agtaccgcga cgtcggcagg ctgagcacga
    10201 tcgtctcgtt cccgatcgtg cgcgccgagt agtcgcccgc ccgcatccgc atgccccgtg
    10261 agtcgggcat ccgcccgtgc ccgttacacc tgtcaggcga acggccggaa caccggacgg
    10321 accgggcgcc cgccgctcca cggggcgggg tcgcccacgt cgagcgcgcg ccggtacacc
    10381 gcgcaggccc gcgcgacgac ctcgaccgtg cggtcgacgt cgtcgtcgga gagcgcactg
    10441 ctgaccacga aggacggtcc gatcaccccg cccgcgagca gctgccgcag gaacagcgtg
    10501 cggtaggcct gcgacggccg gaggtcggcg tcgagggtcg cgaacacgag gttgctggcc
    10561 cgtccgcgga cgagcacgtg ctcgcccacc cccgccgcgg cggcgaccgc gcgcacaccg
    10621 gcggcgagcc ggtcgcccag cgcgtgcatc cgggcgacga cgccctcctc gcggtaggtg
    10681 cgcatcaccg cgatcgccgc ggccagcgcg tgcgtctcgg caccgtgggt ggtggacagc
    10741 aggaacaccc gctcgcgttc gtcgcgcagg ccgcccagct ccatgagctc gcgccgaccg
    10801 gccagcgcgg agacggcgaa cccgttgccc agcgccttgc cgaacgtcga caggtccggg
    10861 gtgacgccgt agaccccctg cgccccggcc tccgaccagc ggaagccggt gatcatctcg
    10921 tcgagcacga ggacgcagcc gtgccggtcg gccagcgcgc gcaggccctg caggtagccc
    10981 ggcggcggct cgacggcggt ggccgcctcc aggaccaggc aggccacccg gcccgcgtgg
    11041 agctccagca cctccgcgac ggcgtcgagg tcgccgtagg ggaacgtgac ggtcaggtcg
    11101 gtggtgaccg cggggatccc cgccgacatc gccgtcgtgc cgatgaacca gtcgtcggtg
    11161 gagaagaagg gctggtcgcg gcagatcgcg acgagcggtc gcccggtcgc ggcgcgggcc
    11221 agccggaccg ccgccgtggt cgcgtccgac ccgttcttcg cgaacttgac catctccgcg
    11281 gtcggcaccg tctccaggaa ctcctgggcg gcctcggcct cgatggcgct gggccgcacg
    11341 aagttggtgc cccggccgac ctcgcggcgc accgcctcga cgacccgcgg gtgggcgtgg
    11401 cccagcccga ccgaccgcag gcccgacccg tactcgatgt aggcgttgcc gtcgacgtcc
    11461 cacacgtgcg cgccgcggcc gtgggagatg accggggcca tgtcctcggg gtactggtcg
    11521 tcgcccttgg cgtaggtgtg ggagccgccg ggcaccatcc ggtgcagccg ggcggcgatc
    11581 tcggcggagc gcggcacggc ggagcgggcg accgccccgt cgacgggcgc ggtcgtggtc
    11641 acggcgggtc ccccctcggt gcggccggca cggcggtgcg ggccggtacg gcggccacca
    11701 ggcggacggt gacggtgacg gtgacgacgg ccaggcacag cccgccgagg gtgtcggtgg
    11761 cgtagtgggc cgacagcgcg acctgcgcca cggccatgac gccggccgcg acgacggtgc
    11821 ccgtgacgac cagcgccgcg gccgccaacc tccccggccg taccaggtcg acgaggagca
    11881 gcagcaggac cagcgcgagc acggcggccg tggcggtgtg cccgctgggg taggccaggt
    11941 tctccgggcc gtggatcgtg cggccgatca gcggcttcag cgaggcgacc gccaccgcgg
    12001 tcagggccag cgcgagcggc gcgacggcgg cgaggcgcgc gcgcccgcac agcaggcagg
    12061 cgagcgcgat cagcacggcc agcccgaccg ccaccaccgg ttccccgacg aggtcgacgg
    12121 cgaggagcag gtcgtaggag gacgcggtca gcccggccgt cgcggccgcg gccgcccggt
    12181 cgaccgccca cggcgcggtg ccgccgagca cggcgagccc gagcccgagc aggacgagcg
    12241 cgcacagggc cgccgtcgcg tcggccgccg accggccggt ccgggcgggc cgcacctcag
    12301 cgcgggaccg ggacggcgag ggcgacgggc gggagcgcct cctcggcggc gtggtgctcc
    12361 cacagcatcc acggccggtg gccggtctgg taggcgatct ccagcgcgtt gcgctccttc
    12421 accgtgtcgg ccggctgcca gaacccgcgg tgccggtggg cgagcatccg gccctcccgg
    12481 gcgagcgcgg cacaggcgtc ggcgacgagg tccccgcccg gcggcaggta gtcgaagacc
    12541 tccggccgca gcacgaagta gccgccgttc tcccagagcg ggagctgctg cagcgtgctg
    12601 atcgccgaga tgcggtcgtc gtcgcccagg tcgacgcagt ggaaggccga ctgcggcggc
    12661 accgcgagca gcgcgcccac ggcctcgctc gccttgaacc ggtcgatcat gtcggccagc
    12721 ggcaggtcgg tgagcacgtc ggcgtagttg gccaggaaca tctcctcgcc ctcgacgtgc
    12781 tcgcggaccc gccgcaggcg ctcgccgatg gcggagtcga gtcccgtgtg gacgaaggtg
    12841 atcgtccagt cctggatgtc ggagcccagc atctcgatgc ggccgccgcg caggcggaag
    12901 tcgttggacg cggtctcgga gtagtgcagg aagtagtcct tgacgtgctc ggcgccgtac
    12961 ccgaggcaca gcacgaagtc ggtgtggccg aagtgggcgt agtagcgcat gacgtgccag
    13021 atcagggggc gcggcccgac cgtgtgcatc ggcttcggca ggtccgacgt cccgtcgcgc
    13081 atccgcatcc cgtaaccgcc gcagaagagg acgaccttca tcgtgcacac ctcgtctcgt
    13141 ccggatcggg tgttccgcga caggactcgc gggcgcggtc cggggcgtta cccgacggca
    13201 gggaggtaac gcaacgtgca cggcgcccga gtctgtcggc acctgttccc cgcgcacgct
    13261 cctggcgtgc agcgacacac ctggaggagc cgtgaccgcg attctcagcg agatcggtcc
    13321 gaacctctcg tcggtggtcc ccgccacccc gtcgtgccgg ctgtgcggtt cccccgacct
    13381 gcgcagcttc ctcgacctcg gagcgacgcc cccgtgcgag ctgttcctga cggccgaggc
    13441 ggcgggcgcc gcggaggtga cctacccgct gcacgtgctc gtgtgcgccg gctgcctgct
    13501 ggtgcagctg ccgccgctga tcacgcccga ggagaccttc accgagtacg cctacttctc
    13561 ctcgttctcg acgtcgtggg tgcgccacgc cgcggccttc gtcgacggtg cggtggagcg
    13621 gctcgggctc ggtcccgact ccttcgtcgt ggaggtcgcc agcaacgacg gctacctgct
    13681 gcagcacctg gcgccgcacg gggtgcgctg cctggggatc gagccgtcgg ccaacgtcgg
    13741 cgacgccgcc cgcgagcggg gggtccccac ggtcacctgc ttcctcaccc ccgagaccgg
    13801 gccgcgcgtg cgcgcgcagc acgggccggc cgacctcgtc gtcgccaaca acgtctacgc
    13861 ccacatcccc gacgtcctgg gcttcacgcg cgggctgcgc tcgctggtgg ccgacgacgg
    13921 ctgggtgtcg atcgaggtgc agcacctgct gacgctcgtg cagcgcaccc agttcgacac
    13981 cgtctaccac gagcacttcc agtactacac gctgctcacc gggcagcggg cgctcgccga
    14041 gggcgggctc gcgctcgtcg acgtcgagct gctcgacacc cacggcggct ccatccgcat
    14101 gtgggcccgc cccgccgccg cggtcgggcc ggacgacgtg tcggaccgcg tgcgcgacgt
    14161 gctggccgcg gaggccgcgg ccgggctgca caccgtcgag gggtacgacg gcttcgccac
    14221 cgcggtgtcc cgcgtgcgcg acgacctcgt cgagttcctc atcgaggcgc gccgcgacgg
    14281 gcgcaccgtc gtcggctacg gcgcgcccgg caagggcaac acgctgctca acttctgcgg
    14341 catccgcccc gacctgctgc cctacacggt cgaccgcaac ccctacaagc acggacggct
    14401 cacgcccggc acgcggatcc cggtgtgccc cgtcgagcgg atcgcccacg accgccccga
    14461 ctacgtcctc gtgctgccct ggaacctgcg cgacgagctc gtcgagcagc tgtcctacgt
    14521 gcgggagtgg ggcgggaggc tggtgttccc gatcccgcgg ttggagatcg tctgaccggt
    14581 cgtcccaccc tccgccagcc acgcctggtg cagcagggcc atcgaggggg cgtgcggcag
    14641 cggggagagc cagtgctccc gcagcaccgc ggcgtcgacg aggtcgtggt cgacgccgtc
    14701 gccggtccag ccgcgcgcga agtcgcgggt gtgcgcggcg aacaccgcgc cgttgaaggt
    14761 cgccttcgtg gcgcgctcga gcacggcgcg gggcagcagg tcgtcgaaga ggtggcgcat
    14821 cgccgtcgtg cgcccggtcc agccccagaa gccggcctcg gccgccgtcg cggcgacgaa
    14881 accggggtcg acgaacggct ggacgtagcg cacgccgatc tcctcgccca gcgcccgcag
    14941 cgtggcgtac ccgatccggg aaccgcggtg cgaggcgagc tgccaggtct ggcggcccgc
    15001 gtgcagctcc tcggcggcga cgtcgtcgag gtggcggcgc agcacctcgc gccacgcgtc
    15061 cgcgcgcagc cacgggggcc ggtagctctc ccgccgggcg gtccggcggc ggaacgcggc
    15121 gggcgcgagc gcctgcgccg ccagcgggac cagcctgcgg tcggcccggg tgcgcgtgtg
    15181 cagcagcttg gtcagcgcgg tgatccgctt gacgccgaac acctcgtcgc cgccctcccc
    15241 ggtcagcagc gagccgccgc gggcgcggtc catcatccgc caggtcgggg cgacgttcgg
    15301 cggccagatc acgccgtggc ggcgcaggag cggtgccgcc acgggcccga cggcgtcgtg
    15361 ctcgtcgtgc acgaccagca cgacccgctc ggtgacgccg aggtggtcga gcacccggcg
    15421 ctgccagtcc gactcctggg cgccgggggc gtcgggatag gtgagcgtga tcgcgacggg
    15481 cgggggcagg ccctcgcggt gggcggccgc gacggcggcg gcgagcagcg cggaggagtc
    15541 gcgccccccg gagaaggcga cgaggcacgg cggccgggcg agcagcggca cgagcagggc
    15601 gtcgagcagc cggcgcggtg ccgggccggg tggcgcgggc agcggggggc aggggctgtc
    15661 ggcgagccag ccgctcgcga tctccagcgg ctccatccgg tggagagcca cggtcgctcc
    15721 tctcggcgcg ggagcggggc cggtggacgg gccaccggcc ccgcgacggg cggtcaggag
    15781 tgcaccggac taccgccgaa cggcacgttg accccgaaga tcgagtcctg ctgtgccgtg
    15841 aaccggaacc cctgggtctc ctcgatgacg gagcccagca gctcgatctc cgggggttcg
    15901 tagggctggc gcatgtacac ctcctctcgc gcgtcgacgg gacgggacgg gggcgcggac
    15961 gacgccggga cgccctcgtg gagtgggact cggacccgcg ggcgggcccg ttacgccccc
    16021 cgtgtccggt cccggcgcga ccgggccgga ccggtgaccg cctcgaccag ctcggccagc
    16081 accccgggcg ggaacggcgg accccacggg atcgaggcct gcacgaccgg cacgacctgg
    16141 accaggtcgg ccagcgcctg gaactgcgcg gccgcggctg ccggctcccg ccagcccacg
    16201 acccgcggga actgcacgag tcgcacgagg gcctgggcgg gcgacagcgg gcgcaccgcg
    16261 acctccgacg ccgtccggtt cggggccggc agcacgcacg ccgccagggg cagcggggcg
    16321 cccgcgcgga cgggcagcgc cagcgccagc cgtccgtcgg cggtggcgcg gacggcgccg
    16381 ggcggggcgt cgtcggcgag ggcctgcgcg gccggccgca gacgcgcctc ggtgctgccc
    16441 ggatgcacgc ggggtacgtc gccgggctcg acgcgcagca cgtcgtcgga gaccagggcg
    16501 tggccggcgc cggccagggc cgccgcgagc gtcgacttgc cggtcccgga cgccccgacg
    16561 aacgccagcg cccggccgtc gacgtccacg gcgctcgcgt gcagcaccag cgcgtgccgc
    16621 agggtcaggt gcacggcgag cagcgcgccc gcggccagca ccgggaccag cccggcgtcg
    16681 gccgccgggt cgaggtggac ggtgacctgg cgcagcgcgg cgtcaccgac gaagtcgcac
    16741 aggcccgggt agcgcagcac gacggcgtcc gcggtgcggg tgaagcagta gtaccgcccg
    16801 ccgccggggc ggtcgagcgc ggcgagcagc gtccccggcg ggtcggcgca ggggaccggg
    16861 cgacgcagcc cggcccgcag gacgaggtcg ggccggccgc cgctgcggcc cgcgcgggtg
    16921 accgcgtcgg ccggcagcgc cagcgcgacg gtgctgcgga cgcgcagtcc gtgcgcgcgg
    16981 tagcggtgga gggtcacggg cgggccgcgc ccagtgctgc gaaggcccca gcggccggat
    17041 cgagcggacg gccgtcgacc tcgagccagg agtgcgccga gaaccggccg tcgccggtgc
    17101 ggcggacgcc gatccgcagg acgggcccca ggccgcgcag ccggtgaccg gtgagcaggc
    17161 agcggcgcag gcaggtgtcg cccgcgggcc agtgcgcgac gacgagcgcg caggcgcgca
    17221 cgacgcggcg ggtccggcgg gggagcacgg cggtcggtcc ggcgcgggag atcgggtccg
    17281 tcgtcgcccg tgccggcgcc gcaggcgcgg tcaggtcgtg ggcgacgccg agccggcggc
    17341 acgtcgtcgg caggtcggtc gtgcgcagca gcacctcgac cgcgaccatc ggcccgagcg
    17401 cgcgcaggac ctcgacggcc ccgagcgccc acctgcgcgc cgtcatcgct cccgcacctc
    17461 cgccggccgg gcggggccgg atgcccccgc ggccgatgga gtcgtcggac ggcgcagcgg
    17521 cgttacgccg tccgcgacga gcggttcagc gctccggtac gggccgtgca ctgccggtga
    17581 ccgcccgcac gtcccgcgat cccgtccggt cggcgcgtcg atcgggccgg tcggcgcgag
    17641 cgaggcaacc tccccgcctc ccgacggcat gctgacgcgc ggtcatgaac gtggccgtcg
    17701 caggcgtcgg gagcggacat ggcggtgctc ggctgggtga tgggcctcgg aaccctgtgg
    17761 atcgcgtgcg cgtgggtcgt cgcggtcgtc ctcggagggg tgatcctgag gtccgggacc
    17821 gtgcgcaccg caccgtcggc cgccctgcgg gccggtgtcc cgtcctccgg tgccctgtcg
    17881 tccggtgccc tgtcctccgc cttggcgtcc gtgcccgccg cggcgcgcac cgccggcacg
    17941 cccaccgcag ccgagatcgt cccgcagccc cggaccgccc tcccgcgccg cgacccccgc
    18001 gccgggtgcg tccgcaccgg ccgccccgcc gggcgcgact gagacgcatc cctcccttct
    18061 ggccgtgagc ggaagacggg gactgggaac ccggttgcgg ggtacagcgc gtgagtgctg
    18121 tcctgcgtcc gtgcgtgccc gagtggtgac gaagcgtcca caagatccgg agtgtcaccg
    18181 ccgacgctcc ccgatcgggt gatcagccgc tccgacggag tgggaaacgg tgtgggggcg
    18241 gcgtgtcgcc tcgacctgcg gatgtgcacg tcaggacgcg aagccggcag cgcactgtga
    18301 cctaggtcac gtaacagtgc gccacctcct gcgttgagta ggtgggggac ttttcagggg
    18361 ccgtgccggc gcgccggagt tcgcgcgcga cgacgcggat cactgcaagg aggatgtgtt
    18421 gagcagcgag gtcgggaccg gtccattgcc ggtcatcggg gaaccgcgtc acgtacgggg
    18481 tgacctgggg agcgagcacg gccagccggc cgtggaggct ccgcgcacgt cgtgggaggg
    18541 ccgctacacc gccctcgtgg tgctggcgga cgtgctggtc gtgggagcgg ggacgctcct
    18601 ggggggatgg atcagctcca cgttcctggg cgtgccggcc gtgccgaacg cctggggcct
    18661 cgccggcatc gccggcctgc tcacgctgat ctgcctgtgg gtctggcgcg cctgggagcc
    18721 gcggacgctc ggccagggct ccgaggagtt cagctcggtc ctgcgcggca ccatcaccag
    18781 cctggtcctg ctcggcctgt tcggcctcgc cttcgagctc agctcggtgc ggccgtgggc
    18841 cttcgcgttc atcccggtga tcggcatcgc catcgccgcc gcccgctacg tcatgcgccg
    18901 cgcgctgcac cgccgccggt tcaccgggca gtgcatgcac cgcgtgctcg ccgtcggcac
    18961 gccgcagtcg atcgcggagc tcgtcgtccg cacgcgcgac aacccccact tcggctggca
    19021 ggtcgcgggc gcgtgcaccg ccagcggcta cggcctcgac ggcgacacca ccatcgcggg
    19081 cgtccccgtc gtgggcgacc tggaggcgct gcaccgcgtc gttgacgccg ggcactaccg
    19141 cgtcgtcgcc gtcacgccca cgcccgactg gtcgccgcgg cggctgcagc ggctgtcgtg
    19201 ggagttcgag aactcgcagg ccgagatcgt cgtcgacccg ggcctgctcg aggtcgccgg
    19261 tccgcgcctg cacgtcaagc cggtcgacgg cctgccgctg ctgcgcctca ccgagccgcg
    19321 cttcagcggc atcgcgaagg tgatgaaggg ctgcttcgac cgcttctgcg ccgtcgtcct
    19381 gctgttcctg ctgctcccgc tgctgatcgg ggtcgcgatc gccgtgaagc tcgacggcgg
    19441 gccggtgttc ttccggcaga tccgcgtcgg gcgccacggc gagacgttcc ggatggtcaa
    19501 gttccgctcg atggtcgtcg acgccgagaa gctgcgcgcc gacctcgtca cgatgaacga
    19561 gggcgccggc ccgctgttca agatgcgccg cgacccccgg gtcaccgcgg tcgggcagtg
    19621 gctgcgccgc tactccctcg acgagctccc gcagctgttc aacgtgctcg gcggctcgat
    19681 gtcgctggtc ggcccgcgcc cgccgctgcc ggccgaggtc gagggctact ccaccgagac
    19741 ccaccgccgc ctgcacgtgc gccccggcct caccgggctg tggcaggtca gcggccgcag
    19801 cgacctgtcg tgggacgagt cgatccggct cgacctgcgc tacgtcgaga actggtcgct
    19861 cgccctcgac gcgctcatcc tgtggaagac cgtcggtgcc gtgctgcgcg gtgacggcgc
    19921 ctactgagtc accgtccgca cccgccgccc gagggggtgg caggtgaagc cggcccggcg
    19981 caggacgtcc gggtcgagca ggttgcgggt gtccacgacg atcgggcgga ccgtcagccc
    20041 ggccagcgcc ggccagtcca gcgtgcggaa ctgcggccac tcggtgagca cgacgagcgc
    20101 ctcgacgtcc cgcgccgcgg cctcggccgt ggccaccacc tcgataccgg cgagctccgg
    20161 atcggcgcgg ccgggcgcca cggcggggtc gtgggcgacg agctcggccc cggcctggcg
    20221 cagcagcgcg gccacggcga gcgcggggga gtcgcgcagg tcgtcggtgc ccgccttgaa
    20281 cgtcagcccg agcagcccga tccggcagcg cgagagcgag ccggtgcggc tgccggtgac
    20341 cgcgaggcgc accttgtcga ccatgcggcg gcgctggcgg gtgttggtgt cgatcgccgc
    20401 gcgcacgatc cggaactcga agtcggcggc gtcggccgcc tcgagcaggg cgtgcgtgtc
    20461 cttgggcagc gtcgcgccgc cccagccggg cccgggcgac aggaacgcct ggccgatgcg
    20521 cttgtcgtgg ccgatgccct cggtgacgtc gccgacgtcg gccccgacgc gctcgcacag
    20581 ctccgccagc gcgttgacgt agctcagctt cagcgccagg aaggcgttcg cggcgtactt
    20641 gacgagctcg gcgctcgccg cgtcggtcag caccgtcggc gcgcccaggc gggagtacag
    20701 ggccgccacg cgctcggccg cgtcctgcga gtcggagccg acgacgatcc ggtcggggtg
    20761 gcggaagtcg tgcaccgcgg tgccctcgcg caggaactcc gggttgctca cgaccggcac
    20821 gtcgtcgcgg cccagcagct cgcggacgcg cggcgcggtg cccaccggca ccgtcgactt
    20881 gacgacgagc acgcagcccg gcgccaggtg cggcccgacc tcctcgacgg cggcctgcag
    20941 cgcggtgagg tcggcgacgc cccccgcgcc gaccggcgtc ggcacgcaga ggatcacgac
    21001 ctcggcggcg ccgcgcgggg tcgacagcgc cgccgccgca cccgcgacga gcgacagccg
    21061 ccccgcgctc agtccctcgt cgacgagcgc ggggaggccg ggctcgcgca ggggctcgtc
    21121 acccgcacgg aggcgggcga tcagcgccgc gtccgggtcg gcgcaggtga cccagtgccc
    21181 gagcgcggcg aggcaggccc cggtggtgag gccgacgtaa ccggccccga cgacggtgat
    21241 gcggcgggcg aacacgggcc gaccgtactg cggacggccc atcctttcgt cgacgctccc
    21301 cgcacgctcg gcgcagaccg gggcggccgg ccgagtgatc cggatcgtca cgctttcggg
    21361 tgataggttc gcccccggtc ctgccctgcc gggtgcgctc cccgctccgc ccggcgcgaa
    21421 ccagcacaga ggtcaccaca tgcgcgctcc cgaggcaccc ccgatcgagc cgaggcaccg
    21481 ccggtccgcc gcgccggcgc cgcggcgcgg gttcggtggc cgctggctcc cggtgggcgt
    21541 cgtcatggcg gtggcggcgg tgtgcgcggg cgtgtacgtc gtcgaccagc tcacggtgcc
    21601 cccggagatc gcgcagcccg acctgctgtc gctgatcccg cccacccccg acgtgccccc
    21661 ggtgctcgcc gcgcccgccg ccgtcgacag cgcgcccagc gccgagcccg aggccacggg
    21721 acccgccacc gaggaggcgg gatcgggagc ggggtcgggg gaggccgcgg cggagggctc
    21781 cggggagccg gccgccacgg gcaccacgcg tcgtcgcgtc accggcaacg cccccggcgg
    21841 cctgccgtgg cgctccgggc tggtcatcgg gacgcagagc gaggtcgacc gctgggagag
    21901 cttccgcggc cgccccatcg acgtcgtgca cggcttcagc gaccgctcct cgtgggagga
    21961 gatcgagtcc gcgagctgga tcctgtcggc ctggggcgac tcgccgcacg ccctcgtcat
    22021 ctcccagccg ttctggccgg agggctccgg cgggagcctg tcggagtgcg cgagcggtgc
    22081 gtacgacgcc aactgggccc gctacggcac cgcgctctcg aacgccggcc gcaccgacgc
    22141 ctacacccgg ctcgcctggg agttcaacgg cgactggttc gagtggagcg ccaccgacgt
    22201 cacggcgtgg aagcagtgct accgccaggt cgtgcaggcc gtccgctcca ccgccccgga
    22261 cgcgcgcttc gagtggaaca tgaacgccca cggctcccag acctccgacg gcgacgcctg
    22321 gaagtcctac ccgggcgacg acgtcgtcga cgtggtcggc atcgacccct acgaccacta
    22381 cccgacctcc accaccgccg ctgagttcga cgagcagtgc cgcgacagcg agggcctgtg
    22441 ctcggtcatc gacttcgccc gcgcccacgg caagggcgtc ggcgtcacgg agtggggcgt
    22501 gatcagctcc ggcatcggcg acaacccggt gtacatggag aagatgcacg agacgttcct
    22561 ggccggggcc gacgtgatgg agtacgagac gtacttcaac gagtcggcct tcgccaccac
    22621 gctcgacgac ggggccaacc cgcagtcggc cgaggtgtac cgcagcctgt ggggcggctg
    22681 aggttcctgg tgggtcctcg ggggcgcggg ctgagctgtt ctgcccggtc ttacgcgggg
    22741 cgcgggtgat cgtcaggacc gtgctgtcac ggttgtcgct ggggctgtga ggtcgcgttc
    22801 tcggtgatca tgcggccccg aaccggagtt ctgcgtttcg cggaacgcgg gcggctgtgg
    22861 gcccgggtcg ggtgcgcgga ccacgggatc gccgggatcg tgacgctgcg gtcggtgcgg
    22921 gggccgtggt ggcgccttct cgacgatcat gtctcggcac ctgctccggc gcgctcggaa
    22981 cacggaggtg cgacggggtt gtggccctgg gcatcggggc cggccctgcg ctccggtcgc
    23041 gttccgcgga acgctccgtt ccgttgtacg tgggtgatcg tcaggaccgc gccgtcacgg
    23101 tcgtcgcaag ggccgtgagt gacgttctcg gtgatcacgc ggcccgaccg atttgtgtgc
    23161 gttccgcgga acgcggaccg gctgtgaatc cggcgcggtg gcgtgcggac gggtggggcc
    23221 gcggggatcg cggggatcgc ggtgatcgcg gtgatcgcgg tgatcgcggt gatcgcggtg
    23281 atcgccggaa gtgtgacgct gcggtcggtg ccggggccgt ggggtcacgt tcccgacgat
    23341 catgcgtcgg cacccgctcc ggcgccttcg gaagttggga ggcgatggcc ggcgcgagcg
    23401 ccggccgccg tcgcctcggc cgcgttccgc ggaacgcggg tgatcgtcag gaccgcaccc
    23461 tcacggtcgt tgcagggacc gtgaggtgac gttctcggtg atcacgcggg cccggacccg
    23521 gagttctgcg ttccgcggaa cgcggacggc tgtgggcccg gcgctgcggc gtacgggcgg
    23581 gtgggcccag ggggatcacg gtgatcgtca ggaccgcacc gtcacggtcg tcgcagggac
    23641 cgtgacggtg acgttctcgg tgatcacctg gctccgaccg gtcctgtgcg ttccgcggaa
    23701 cgcggacgac gacggagccg acgtcggtgt cccgaacgtc cggaagggtg cggagcagga
    23761 gggtgcgcgg ttcggagcgt tccgcggaac gcgagcctgc aggggagcga ggaggggccg
    23821 ggtcgcgcgg accacagtga tcgccgagac cgtcaccctg cggtcggtgc aggggccgtg
    23881 acgtcaccct ctcgacgatc accccgtcgg cacccgctcg ccgaggccgg gcggcagcgc
    23941 cgcgaacgat gcaggcgtca ggccgccgcc cccaccgtcg ccagcaccac ctccaccacc
    24001 cgcgcccgct ccacctcggt gaggtcgttg gccatcggca gggccagggc gctcgcggag
    24061 agggcctcgg acaccggcag ggcgctctcg agcagggcgt gggcgtaggc ggggtggtgg
    24121 tgcagggggc gctcgtagta cgccgtgatg ccgacctgcg cctcgcgccc ggccaccagc
    24181 agggcgtcgc gggcggcggg gtcgggggcc tgcaggtagc ccgcctgcca ggtgccgccg
    24241 gccgagccgg tctggaagcg gaagcccgcg ggctccaggt gctgccggta gaactcggcg
    24301 gtggagcggc gggcggcgag gacgtcggcg taggtgtcga gcaccgtgag cgccgtggcc
    24361 gcgtgcagct cgtccatctt cgcgttgatc ccgggcaggg aggccacccg gccctcggcg
    24421 aagccgaact gccggatgcc gtcgagcagg cgggccagct cggggtcgcg ggtggagatc
    24481 atcccggcct cgcccacgcc gaacggcttg gtggcgtgga aggagaagac gtgcgtgccg
    24541 gtggcggtgc cggtgcggga cccggcctcg tcgacggcgc cgaacgcggc cgccgtgtcg
    24601 acgacgagcg gcacgccccg cgccgcgcac gcgcccgccc agcggtcctg cagcccggcg
    24661 ggcggaggag tgccgaaggt gtgggtggcg agcaccgcgg cgacgtcgtg gccgtgctcc
    24721 gccagcgccc gctccagggc gtcgggatcc atctgccagc cgtccgggtc gacgtcgacg
    24781 aacagcgggc ggtagcccag cgcctcgatc gacccggcgg tggcgacgaa cgtgtaggcg
    24841 ggcgtgacga ccagcccgcg gccgcgggtg ccggcctggt gcacggcccc gagcacggcg
    24901 acgatgatcc cgctcgtggc gttgttgacc gggatgcagg tggcgccgtc gaggtagtcg
    24961 gacaggcgct cgcgcagcag ccgctcgcac gggccgccgt tggagtagaa gcgggcctgc
    25021 tcggcgaggg tgaagtagcg ctgcacctcg gtgagcgggg ggagctgcgg gcgcaggaac
    25081 gggacgggcg cgtgctcagc cacgggaccc gccggacggt gccgggatca ccacggggat
    25141 gccgtggtca ttggcccact ccgcggtctc cgccgcgacg gccgcccagt cgatcttctg
    25201 cgtgcgcgtg ctgagccggc gcggcgggtc gtccggcgcc tccatgtgca ggatcagctc
    25261 ggggtcgctg cccaggaggg cgcggcgccg ctgcgggcgg cgcaccgaca ccgggatcga
    25321 cgccacgcgc agcgcgccgc gcacgaccga cttgggccac tgcgcgggcg gcacctcgcc
    25381 gaaggggagg aagtcgcggc gcaggcgctg cccggtgaac ggcgcgaagc cctggatggc
    25441 cttgcaggtc gcgctgtccc acgctccgcc ggtgagggcg aagtggcgca gcagccgcac
    25501 gtcctcggcc agcgcgcggc gggtgatcgc gaaggtgctg gtggtggccg cggcccggta
    25561 ccacgccacg tcgccgacct cgacgtactg cccggtgccc tcggcggccg gctccgggcg
    25621 gatgacgggg cggcgcccgc tgcgctcgac gtcgacggcg cgggagccgt agagggtgaa
    25681 gtagtcggcg ggcagggcgg cggcagcggc gacgagctgg cgcagggcgt cgggcacgta
    25741 gaggtagtcg tcctcggcga gccagagcag gtcgtcgggc tcgccggtgc gcgcgttctc
    25801 gtcggcgagc atctcgcggt aggagttggt gtcgctgccg cccctgcgga ccggcacgac
    25861 ctcgccgaag cgctccatca cgcgcaggcg ctcgtcgggc atcggtccgt cgttgatgaa
    25921 cacgagctcc ggggcgacgt ccagcgcgtc ggcggcgcgc agcagtgcgg cgagggccag
    25981 cagcttgctg tagtactccg ggcgtggctt cgcgttgtcc ccgccgtagg accggtgcag
    26041 gacccgcagg ggccggctcg tggccgtcgt catgtcactc cgttcgcggt ggcgctcagc
    26101 gtgaccgcca tctccgtcac gcacctgccg tggagccgac ccgcatcgct cgagcgtgcg
    26161 cggatcggcc cggacactct ctcatcggac ccgtccgggc ccgcacccgg cactcgtccg
    26221 gacgggacgg ctaccgctgg tgggtggggc ggtgcccgtt ggtgagggga gggggtccgg
    26281 ccgggggagc ggggcggcgc aggacgggca ccgccatcgt ccggtcgggg gcgttgtcga
    26341 acgcggccag gcggggaccg ggcaccggcg aggcgtgcac gggcggtgcc ggggcggggg
    26401 agcgccgccg cgccggctcg accgccgccg ccgagctcag gcgcacccgt ctgcccgcga
    26461 cctcaccggc ccgcgccgcg gcgaacaggc cggtcagcag ccagcacagg tacaccgtct
    26521 gcggctgcag caggctcccg gacagcacga agtagacggt ggcggccatc aaccccagcg
    26581 tgggcgacgg gacgttgcgc agcagcaccg tcaggatgaa cgcgaggaac accagcgccg
    26641 tcggcacgcc gtactcgccg atgaacttgg gcagcgccgg gtagttgacc agcaggccct
    26701 gcgggttgaa gaaggcgacg tcggagtcga cggtgcccgc cccgcgcccg accaggaaca
    26761 cgctctcgtc gcggccgatc gcgtcggcga tgacgacgta gggcgcgacg aaccgcgcgt
    26821 tgccgctgga gcccgacgtc gagctctcgc cggtgcgctc ggcgagcagc gcgcccaccg
    26881 gggtgaagct gacggccacg gcgacgacga acgtggcggt gatcgcgcgg gccgtccagc
    26941 ggccgccgcg gcggatcgcc agcaccacca ggccgacgcc cagcagcgcg atgccggtgc
    27001 cggacaccgt cgcgagcagc gcggcgccga agagggcgag acggccccag cgcttcccgt
    27061 cgagcatgag ctgcacgatg atcgcgatcg ccaggaactg ggacgcgaag ctgggctcga
    27121 ggaagacgaa gccgttggcc ttgaggatcg gcgacccgta gtagatcggg taggtcgtgt
    27181 tgtactcggt gaagatcagc gtggggggca ggtaggtgtc gaacaggtcc tcgtagccca
    27241 cccccgcgag ctggatcgcc gtctgcagga tgcagaacac cgcgcccacg agcatgatcc
    27301 gctggtagaa ctccagcacc cgcgggaact ggtcgcgcag gcggtccttc acccggaagc
    27361 acagcgggat gtagaggacg agcagcagca gcagcgacgt gaacgagggg gcggggcccg
    27421 accccgccga caccaccacg gtgcac
//
