LOCUS       NZ_CP053564            21564 bp    DNA     circular CON 29-MAR-2024
DEFINITION  Pseudonocardia broussonetiae strain Gen 01 chromosome, complete
            genome.
ACCESSION   NZ_CP053564
VERSION     NZ_CP053564.1
KEYWORDS    RefSeq.
SOURCE      Pseudonocardia broussonetiae
  ORGANISM  Pseudonocardia broussonetiae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Pseudonocardia.
REFERENCE   1  (bases 1 to 7177725)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-MAY-2020) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013155125.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:16:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,087
            CDSs (total)                      :: 7,032
            Genes (coding)                    :: 6,962
            CDSs (with protein)               :: 6,962
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 70
            CDSs (without protein)            :: 70
            Pseudo Genes (ambiguous residues) :: 0 of 70
            Pseudo Genes (frameshifted)       :: 19 of 70
            Pseudo Genes (incomplete)         :: 48 of 70
            Pseudo Genes (internal stop)      :: 6 of 70
            Pseudo Genes (multiple problems)  :: 3 of 70
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:38:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2175721
            Orig. end                         :: 2197285
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053564.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Mo.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21564
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="5"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21564
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21564
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11564](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11564
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            complement(335..1534)
                     /locus_tag="HOP40_RS10750"
                     /old_locus_tag="HOP40_10750"
     CDS             complement(335..1534)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332943.1"
                     /locus_tag="HOP40_RS10750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10750"
                     /product="sensor histidine kinase"
                     /protein_id="WP_172157244.1"
                     /transl_table=11
                     /translation="MRSVTGRERFEDGLRAVAFLVVGVVLYLVLPDGVIRWRTDLPEPS
                     TAVALGVLALSCSGIALRRSHPVVGLLVTVGALFLGPFAVGVTHTGSLLALGESLYTAV
                     LHSTRRASRWVAACTGVLTALVALRILLVEDAASAVRTVLSLGLLLAIPVFWGLEVRHL
                     HERAEAERDRAEQERRAAERDRAAAVAAERNRMARDLHDVIAGQLSAIAIQSEAALTVP
                     DADPALLRRVLTQVRQGSVASLAEMRTLIGLLRAGQDDEERTSPGGLERVGALADGGRA
                     TGLTVEVDDRRPPGDLPAAVDLAAYRIVQESLTNAAKHAPGSTVRIVLRHDDGALRVDV
                     DNDLVDAGAGASGGGTGTGLLGLAERAAAVGGRVDAGPRGRSWSVRAVLPAPSPVPVPR
                     "
     gene            complement(1661..2404)
                     /gene="mftM"
                     /locus_tag="HOP40_RS10755"
                     /old_locus_tag="HOP40_10755"
     CDS             complement(1661..2404)
                     /codon_start=1
                     /gene="mftM"
                     /inference="COORDINATES: protein motif:HMM:NF041255.1"
                     /locus_tag="HOP40_RS10755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10755"
                     /product="mycofactocin oligosaccharide methyltransferase
                     MftM"
                     /protein_id="WP_172157246.1"
                     /transl_table=11
                     /translation="MTTATAPRLTMGADGRLRHRIGPGEISNDLAGWIADDLVAPGHIE
                     ASAFERTFVSVVASVDPGWTAFYRNTLDELGRGGAPGGTNAGMAPVHDRAVELALGSVV
                     ELGCCFGFLSLQLVAAGHEVTAVDLSAGTVRLLSRVAPALDLPLHTLTGDATAVPLADD
                     SADTVFAVHLLEHLPPALAPVVVGEMLRLARRRVVVAVPYEDEPNAAWGHVRTFDAAAL
                     DALGAATGRPYRVEDHHGGWLVVDA"
     gene            complement(2453..3025)
                     /locus_tag="HOP40_RS10760"
                     /old_locus_tag="HOP40_10760"
     CDS             complement(2453..3025)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039409.3"
                     /locus_tag="HOP40_RS10760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10760"
                     /product="DUF6328 family protein"
                     /protein_id="WP_205347149.1"
                     /transl_table=11
                     /translation="MGGTGSATERLNRNWDDLLQELRVAQTGVQLLTGLLLTVPFQARF
                     DALVAHQRVVFLVAISLSATATALLIAPVVLHRVLFRRNARRPLVRSGQRFAVAGLIVL
                     GLAVVTVIDLIFEVVAGPLAGIAAAAVAAVVFLTLWVLVPLTVRERNAADGDRIEDDED
                     DEDGDGDGARDGAGPHRAGSKAAVPTA"
     gene            complement(3115..4116)
                     /locus_tag="HOP40_RS10765"
                     /old_locus_tag="HOP40_10765"
     CDS             complement(3115..4116)
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013648.4"
                     /locus_tag="HOP40_RS10765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10765"
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_205347150.1"
                     /transl_table=11
                     /translation="MITRRSLLTGAGALGLGAALAGCAGGTTAPPQASTRTITHKLGTT
                     EISGTPQRVVTMGLTEQDYVLALGVTPVGVREWFGGRPGALWPWAAERADGVPEVLAVT
                     EPSYEQVAALAPDLVLGVNYSMTPEEYATLSAIAPTVGPPVGHADYGAPWQVITEVVGT
                     ALGREEQAAALVAPVEQGFADLRSTIPAGRTGLLAARLEDGTYYAYAEGPAPAFLADLG
                     LALPPAAEALFTGPDRPPVELSPEQLGVLDADVLVLGLYGAFATTGTVDDPVFGNLRVA
                     REGRAILLPEQSTTNGALSFGSVLSLPVALAEMRPRLAAALDGDPATAVPPA"
     gene            complement(4328..5857)
                     /locus_tag="HOP40_RS10770"
                     /old_locus_tag="HOP40_10770"
     CDS             complement(4328..5857)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010242005.1"
                     /locus_tag="HOP40_RS10770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10770"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_172157248.1"
                     /transl_table=11
                     /translation="MENALHRFVRLLRLRGMRISIPEALDAMACAAQPGMMADKEQLRA
                     ALRVALVKDRRDEEVFDDIFDRFFALVKVGDDATGHGHGHGHGDLSDTGELESFTLSEE
                     PSNTPEQGHEHGKPADIRDYFDPDDLAQQYNLHQEANKIDMAAMTDEIVLSKDSQGIDG
                     EGQRVQIETDSLHNAGMPGDISQQQGTKVDADLSVAQQEMLLGWLNSTDGESQDGTEDD
                     AAALRRRMTGVLAGLPEALKKHLEALMALENKVVEGAEAEKVREVDRVGEHERMELEES
                     IRRLAHTLHGGLTHKRKVSSRGRIDSGRTMRRNMRFDGIPFSPITVTRSEDKPRLVILA
                     DVSLSVRATARFTLHLVHGLQNLFGQVRAFAFVADMVEVTDLFEDHPVEQALGLIFGGD
                     VLDVDANSDYGKAFGTFQEEYASAVNRRSTVIVLGDGRGNGNDPNTEAFAEITRRARET
                     IWLTPEPRYSWGLGACDLPEYAEYCSRVRVVRDLSGLETAAHEMAAELVGR"
     gene            complement(5925..7154)
                     /locus_tag="HOP40_RS10775"
                     /old_locus_tag="HOP40_10775"
     CDS             complement(5925..7154)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018332349.1"
                     /locus_tag="HOP40_RS10775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10775"
                     /product="MoxR family ATPase"
                     /protein_id="WP_172157250.1"
                     /transl_table=11
                     /translation="MFESGTGQFDSVDEVVDALGEQGYIADSRLATTVFLVNRLDKPLL
                     IEGPAGVGKTELAKALAKATGRRLLRLQCYEGQDETKALYEWDYGKQLLYTQILREKIG
                     QVVADAPTLEDAVDRIGAQESVFFSERFLASRPLLEAIRSDEPVVLLIDEVDRADEALE
                     AVLLETLAEYQVSVPEVGTFTTKTPPYVVLTSNNTRDLSAALKRRCLHLFLDYPTAERE
                     LEIVRSKKTGLPDALAEQLVGIVRGLRQLELRKSPSISETIDWARTLAVLGVEELNATI
                     LSDTVSVVVKYDKDVRKAIGALPTLVDPNATVPEKGHGHGHGHGHGHDDQDAPAPASRQ
                     SSARDDDEDEDDGGRAVRAAKDTPGRFGNTYGSNPLGGDTGAKPITPPKVPAERGTRSF
                     GAGLGRKRAL"
     gene            complement(7230..8522)
                     /gene="mdo"
                     /locus_tag="HOP40_RS10780"
                     /old_locus_tag="HOP40_10780"
     CDS             complement(7230..8522)
                     /EC_number="1.1.99.37"
                     /EC_number="1.2.98.1"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0046170 - methanol catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mdo"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018332348.1"
                     /locus_tag="HOP40_RS10780"
                     /note="This methanol dehydrogenase is considered a
                     nicotinoprotein, since its NADP cofactor remains is not
                     dissociable, but instead remains permanently bound. A
                     member of this family has been shown to act as a
                     formaldehyde dismutase, able to convert two molecules of
                     formaldehyde (plus one water molecule) into one of methanol
                     and one of formate, with no net change in its redox state.
                     More recently, it was shown in Mycobacterium smegmatis that
                     this enzyme is critical to ethanol utilization, for which
                     the biosynthesis of the cofactor-like electron carrier
                     mycofactocin is also required; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="HOP40_10780"
                     /product="NDMA-dependent methanol dehydrogenase"
                     /protein_id="WP_172157262.1"
                     /sec_met_domain="Fe-ADH (E-value: 2.4e-104, bitscore:
                     347.7, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVEEMLPQFPIKEFHPFPRALMGPGAHELIGPEALKLGFKKTLV
                     MTSGLRGSDIVHKIVESMKYHGLEVVVYDKVESNPKDYNVMDAVGLYQQNNCDSFVSIG
                     GGSSHDACKGARVSVAHDGRNVNEFEGFNKSENPKNPPHIAVSTTAGTGSETSWAYVIT
                     DTTTDPDNPHKYVAFDDSSVTTLAIDDPVLYYSCPVDYTAQCGFDVLAHASEPYVSRIN
                     FDPSLGNALHAIKLTARSLREAVWNPQSYAGREGMMNAQYIAAQAFNSGGLGIIHSISH
                     AVSAFYDTHHGLNNAVALPRVWAFNMPVHYKRFADIASAMGVDTHGMTDVQAAEAALAA
                     SIRLLRDVGIPERFVDVKQDSYSKNRLGQGPTKFYENESIIKGDAADVDRITNHVLGDA
                     CTPGNPKECTFETVRPVVDHCMNGDLDDLLT"
     gene            complement(8689..9765)
                     /locus_tag="HOP40_RS35845"
                     /old_locus_tag="HOP40_10785"
     CDS             complement(8689..9765)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="HOP40_RS35845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10785"
                     /product="DUF952 domain-containing protein"
                     /protein_id="WP_240157622.1"
                     /transl_table=11
                     /translation="MTDVLLHLATTAEWRTHLGRGEVRPSVAEFVHLSGPDQVALPAQR
                     LFAGRADVNLLVLDPARIGVEVRYEPGLPTDPASMLFPHAYGPVPASAVLAVLPYRPEF
                     TAPVLPALDAAGRAVAVLTSVLRRTATSEEPVTGGIAVRTASVPRSNQHNQLLVNGPAD
                     AAAVAADAARVLGDRPRPAALLVGDHLEDTAAALAAAGHTVGALTVMAAPAGGPSSPGV
                     RTVDPDELRPFRDAAWRRAVPDVDAESLAQLSDRWLREAEVVDLRCLAVEHDGAVVAAA
                     VLEVDGATAVLDAVETDPAHRRRGHGDALLAEALAQAGDAGCDLVVLEADAAAHPRHWY
                     ARRGFREVARAWQATLSY"
     gene            9895..9996
                     /gene="mftA"
                     /locus_tag="HOP40_RS10790"
                     /old_locus_tag="HOP40_10790"
     CDS             9895..9996
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983865.1"
                     /locus_tag="HOP40_RS10790"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10790"
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_141279391.1"
                     /transl_table=11
                     /translation="MAPAPDAQSAPEEPVVEETLVEEVSIDGMCGVY"
     gene            10001..10318
                     /gene="mftB"
                     /locus_tag="HOP40_RS10795"
                     /old_locus_tag="HOP40_10795"
     CDS             10001..10318
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019806422.1"
                     /locus_tag="HOP40_RS10795"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="HOP40_10795"
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_172157266.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 1.7e-27,
                     bitscore: 94.2, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAASDAGSAQAADPAFDPSQPFRCSPSVALRPEPFGALVYHFGT
                     RKLSFLKTLPLVEVVRGLEHHPDVHAAIEAAGVEESQRPAYLRALAGLAASGTIEPRPT
                     T"
     aSDomain        10061..10297
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HOP40_RS10795_Mycofactocin_RRE.1"
                     /evalue="6.70E-30"
                     /identifier="RREFam016.1"
                     /label="HOP40_RS10795"
                     /locus_tag="HOP40_RS10795"
                     /protein_end="99"
                     /protein_start="20"
                     /score="94.2"
                     /tool="antismash"
                     /translation="QPFRCSPSVALRPEPFGALVYHFGTRKLSFLKTLPLVEVVRGLEH
                     HPDVHAAIEAAGVEESQRPAYLRALAGLAASGTI"
     gene            10350..11564
                     /gene="mftC"
                     /locus_tag="HOP40_RS10800"
                     /old_locus_tag="HOP40_10800"
     CDS             10350..11564
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499234.1"
                     /locus_tag="HOP40_RS10800"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="HOP40_10800"
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_172157273.1"
                     /sec_met_domain="PTHR43273 (E-value: 4.5e-38, bitscore:
                     129.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.4e-22, bitscore: 78.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-06, bitscore: 26.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 9.4e-08, bitscore: 30.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.4e-14, bitscore:
                     50.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.9e-06, bitscore: 26.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLVDHFQYGLNSPICLTWELTYACNLACVHCLSSSGRRDPRELT
                     TAEAKGVIDELQKMQVFYINIGGGEPTVRPDFWELLDYSIDHNVGVKFSTNGIKLDKQR
                     SQQLARTDYVDVQISLDGATAEVNDHVRGPGSYDTAIRALENLAEAGFGQPKISVVMTR
                     QNVDQLDEFKSIADKYNAQLRITRLRPSGRGADVWDELHPLPSQQKQMYDWLVAKGDSV
                     LTGDSFFHLSAFGEALPGLNLCGAGRVVCLIDPVGDVYACPFAIHENFLAGNLRSPGGF
                     QEIWENSELFTELRQPQTGGACASCMHYDSCQGGCMAAKFFTGLPLDGPDPECVRGFGE
                     QALAARDGVEIPKSDVDHSRSAPRNSRTPKAPVMLQIGMGRPDKSCDPSPLAAPAALTQ
                     ASARA"
     gene            11633..13582
                     /locus_tag="HOP40_RS10805"
                     /old_locus_tag="HOP40_10805"
     CDS             11633..13582
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983862.1"
                     /locus_tag="HOP40_RS10805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10805"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 1"
                     /protein_id="WP_205347151.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.6e-06, bitscore:
                     26.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGPVVLRGRTAPSRVLFGPHVTNLGHRRSLSPRHVAYYARRAAG
                     GAGVVVTEAASVRDSDHPYERAPLAADCADGWRAVADACRPHGALVLAGLGHAGAQGSS
                     AYGQRALWAPSRVADVASREVPMAMEQPEVDALVAGFAAAAALAVDAGCDGVEIGAGQH
                     SLLRQFLSGLTNHRTDAHGRDRALLLREVLTAVRAALGEEPVLGLRLCCDELAPWAGIT
                     PDSAAETLAALPPVDYVVPVRGSGLSVGATRPDLHTPPGFNTLLCALIRTGSSGAYECA
                     EQRAEQRAEHRVVLQGSVVDPAMAQAALDDGLCDLVEMTRAQIADPDLVAHVRAGTPER
                     IRPSTLSNRRTAVRDPRNPIVSDDAEPDAGHETEPVPAPPGPPRDVLVVGGGPAGLEAA
                     RALALAGHRVRLVEREPVLGGALRLAAAVAGRARMGVLVPWWERELARLGVRVETGVTA
                     APADLVGPVVLATGSRPAPLTYPADVAVLAAAEFEAAVLAGGPVLPPGPVVVHDPVGDW
                     TGVGIAEQLAAAGRTVALVTPDPVAGTQLALTGDLAPANARLDRAGVTRERYARLVGVA
                     GGRAELEHVWTGQRWDLACAAVVDCGHRLPADALWRARPDLPRAGDCVAPRTVHEAVLE
                     GRRAAYEAVTGLPC"
     gene            13576..15486
                     /locus_tag="HOP40_RS10810"
                     /old_locus_tag="HOP40_10810"
     CDS             13576..15486
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983861.1"
                     /locus_tag="HOP40_RS10810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10810"
                     /product="mycofactocin system FadH/OYE family
                     oxidoreductase 2"
                     /protein_id="WP_205347152.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 9.1e-12, bitscore:
                     43.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNEPLQVGPLVLRNRLVFPAHLTNYAVDGLPTPQHTAYYAARAA
                     GGAGLVITEEHGVDPYDRPYEKLIEARDGALPGYRALTAAVHAEGAAVLAQLTHNGGQS
                     SGMHSRRPVLAPSPVPDPLFREVPVELDAAGIARIVDGYAATAARCVAGGFDGVEVQAA
                     HSSLVRQFLSPLTNRRTDAYGRDRNRFLLEVVDAVRDAIGPDRVLGVRLCGDEGPAHTL
                     GAHGIGIDDAVATALALAGRVDLLSTAIGVATSTLYLVEASLRFAPGYALSIPEAIRHA
                     VDVPVIGVGRFTTPAQAETALESGRCDLVGVVRGQIAEPAFGTAPVRACVGCNQECVGR
                     VGRNRWLGCVVNPRAGRESVPLPAPGVPKQVLVVGGGPGGLRAAATAAARGHRVVLCER
                     DATTGGAVRLAAAAPGRAEFANVVRDLLGECRAAGVEVRTGVDVDPALVEALAPDAVVL
                     ATGARPAARWPVPGVVDVRDVLSGRVAPVRNALVYDELGFHQAPAAAEWLAAGGSGVEL
                     MTPGLVVAQDLGTTLDAELFHRRAHAAGIVLTTDRVVTGIAPGPEPAGPLVVTVLHHTT
                     GAEERRSYDLVVAVVPPEPDDALWAALRDGPRPVHRVGDCLAPRRAHAAVVEGDRVAVG
                     L"
     gene            15483..16181
                     /gene="mftE"
                     /locus_tag="HOP40_RS10815"
                     /old_locus_tag="HOP40_10815"
     CDS             15483..16181
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018332338.1"
                     /locus_tag="HOP40_RS10815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10815"
                     /product="mycofactocin biosynthesis peptidyl-dipeptidase
                     MftE"
                     /protein_id="WP_172157281.1"
                     /transl_table=11
                     /translation="MTALRLGERTWTDLDEPRTVLVPVGSLEQHGPHLPLDTDARIAAA
                     VARRAADGDPTLLVAPPLAYGASGEHEGFAGTLSIGHEALRAVLVELGRSAARWAARLV
                     FVNGHGGNLPTVPDAVAQLRHEGREVAWFGCAVPRGDAHAGRTETAILLALDPSVVRRE
                     SLEPGNTAPLRDLLPTLVRGGVAAASANGVLGDPRGATAREGEELLEEMVGQLRERLTR
                     WLPDDRGRLG"
     gene            16240..16842
                     /locus_tag="HOP40_RS10820"
                     /old_locus_tag="HOP40_10820"
     CDS             16240..16842
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015097458.1"
                     /locus_tag="HOP40_RS10820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10820"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_172157283.1"
                     /transl_table=11
                     /translation="MSIVSSHLTVSLDGFVAGPDQSLEEPLGRGGERLHEWMFVPDGPE
                     SDARIVEESLSGVGAFVMGRNMFGPDRGPWDPSWTGWWGEDPPFHAPVFVLGHREREPV
                     EMAGGTTFHFVTDGIGAALERARKAAGERRVDIAGGASTVRQYLAAGLVDRLTLHLVPV
                     LLGSGERLFDGLDGLVLEQEEVVVSPAVTHLRYRVAR"
     misc_feature    16256..16271
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     gene            complement(16852..17985)
                     /locus_tag="HOP40_RS10825"
                     /old_locus_tag="HOP40_10825"
     CDS             complement(16852..17985)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684907.1"
                     /locus_tag="HOP40_RS10825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10825"
                     /product="alkaline phosphatase family protein"
                     /protein_id="WP_172157294.1"
                     /transl_table=11
                     /translation="MFPLPLYGHRSLAEVLPALLRALGLPEPESDLVVEPARAAALLLV
                     DGLGRELLDAHAADAPFLSSMADAGPVTVGFPSSTSISLTSVGTGLPPGAHGVLGISFR
                     VGGELLDSLKWTSHGAGDAVDLREALVPEQVQPSPTAFERAEAAGIGVTVVSQRVFRGS
                     GLTRAALRGGRFRGTHALGDLAAEVLAALAGPERRLCYGYHADLDAMGHLHGPGSVAWR
                     MQLAQVDRLVQRIAEDLPPGAVLAVTGDHGMVSVDRIHDADTDDALRQGVLLLGGDARA
                     RHVYARPGAADEVLAAWRAVLGDDAWVVPGEQAAADGWFGPVAPAMRSRIGDVVVATRG
                     TAAVIRSEAEPLISRMPGQHGSLTTAEQLVPLLLVRS"
     gene            18022..19485
                     /gene="mftF"
                     /locus_tag="HOP40_RS10830"
                     /old_locus_tag="HOP40_10830"
     CDS             18022..19485
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013677703.1"
                     /locus_tag="HOP40_RS10830"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10830"
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_172157296.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.3e-20,
                     bitscore: 70.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHGTPVGDEHAGEQGPASTVLPEGLRVALDRRTRSVDDGAVLLGG
                     APPRMLRLARAGRDLLAPGAFTVDGPTSRALARRLLDVGIAHPVGGPAGPGPDAVTVVV
                     PVKDRVDGLARLVAAVGEVGALVVVDDGSADPAAIRAAAGPRARVLRHGRSRGASAARN
                     TGLRAASTPLVAFLDSDVVPEPGWLAPLLAVFADPAVALAAPRIVALAPVVGWLGRYEA
                     VHSSLDLGPDPALVVPRSRVAYVPSAAVVVRREAVGDGFDEAMHVAEDVDLVLRLHAGG
                     HRLRYVPDARVAHDHRTTLRAWWWRKAQYGTGAAPLALRHHGAVPPMVLSPTSAAVAAL
                     ALVGRPWALAAAGVVGAVAVERLSRRLDVRRPRTTAARLVGLGALGAVSQTADAVTRHY
                     WPLSLAACAVSRRARRRVLAVALAEGAVDWWRHRGRDARVRPDPVSHLLAHRLDDLAYG
                     AGLWWGAAAHRTAAPLLPSGPALRVGPNG"
     misc_feature    19524..19538
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 17.93"
                     /tool="antismash"
     gene            19704..20222
                     /locus_tag="HOP40_RS10835"
                     /old_locus_tag="HOP40_10835"
     CDS             19704..20222
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013677702.1"
                     /locus_tag="HOP40_RS10835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HOP40_10835"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_172157298.1"
                     /transl_table=11
                     /translation="MAQVRVTVDGVNYADDVEPRTLLVHYLRERLGKTGTLVGCDTSNC
                     GACTVHLNGQSVKSCSVLAVQADGAEVTTIEGIARDGKLHPVQEAFNEKHALQCGYCTP
                     GMIMQAIDLLGDNPDPDEHEVREGIEGNLCRCTGYQNIVRAVQSAAQKMKPGAHAQTDA
                     PVPVAGGGN"
     misc_feature    20387..20401
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(20807..20820)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(21266..21277)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
ORIGIN
        1 tcgagcagct ggggggccga caccgacttg agcaggaacc cggcggcgcc ggcggcgagc
       61 gcgtcgtcga cgtgggcgtc gatgtcgaac gtcgtcagca cgagcaccgc gcacaccccg
      121 tcggcgacga gccggcgcgt cgcctcgatg ccgtcgatcc ccggcatccg gacgtccatg
      181 agcacgaggt cggggcgcag ctcggtggcg gcgcggacgg cggccagccc gtcgccgacc
      241 tccgcgacga cctccacgtc cggggccgag ccgaggatca tcacgagccc cgtgcggatc
      301 gcggcctggt cgtcggcgac gacgacgcgc acgctcaccg cggcaccggg accggcgagg
      361 gggccggcag cacggcccgc accgaccacg accgcccgcg cggcccggcg tcgacccgcc
      421 cgccgacggc cgccgcgcgc tcggccagcc cgagcagccc cgtgccggtg ccgccgccgg
      481 aggcgcccgc cccggcgtcg accaggtcgt tgtcgacgtc cacccgcagc gcgccgtcgt
      541 cgtggcgcag cacgatccgc acggtcgagc cgggcgcgtg cttcgcggcg ttggtgagcg
      601 actcctgcac gatccggtag gcggccaggt cgacggcggc gggcaggtcg ccgggcgggc
      661 gccggtcgtc cacctcgacg gtcaggccgg tggcgcgtcc cccgtcggcc agcgccccca
      721 cccgctccag cccgccgggg gaggtgcgct cctcgtcgtc ctggcccgcg cgcagcagcc
      781 cgatcagcgt ccgcatctcg gccagcgacg ccacgctgcc ctggcgcacc tgcgtcagca
      841 cccggcgcag gagggcgggg tcggcgtcgg ggacggtcag cgccgcctcg gactggatcg
      901 cgatggccga gagctgcccg gcgatgacgt cgtgcaggtc gcgggccatc cggttgcgct
      961 cggcggccac cgccgcggcg cggtcgcgct cggccgcccg gcgctcctgc tcggcgcggt
     1021 cgcgctcggc ctcggcccgc tcgtgcaggt ggcgcacctc gaggccccag aacaccggga
     1081 tcgcgagcag cagcccgagg ctcaggacgg tgcgcaccgc cgacgcggcg tcctcgacga
     1141 gcaggatgcg cagcgcgacc agcgccgtca gcacgccggt gcacgcggcc acccaccggc
     1201 tcgcgcggcg cgtggagtgc agcacggcgg tgtagaggga ctccccgagc gccagcagcg
     1261 acccggtgtg cgtgacgccg acggcgaacg gcccgaggaa cagcgccccc acggtgacga
     1321 gcagccccac cacggggtgg ctgcggcgca gggcgatccc cgagcacgag agggccagga
     1381 cgccgagggc gaccgccgtc gacggctcgg gcaggtcggt gcgccaccgg atcacgccgt
     1441 cgggcaggac gaggtacagc accacgccca ccaccaggaa cgcgaccgcg cgcagcccgt
     1501 cctcgaacct ctcccggccg gtcacgctcc tcatcccacc acgacaacgg ggcccgcgcg
     1561 tcacgagtgg gtcgagtggg gggctggtgg tcggcccggt gtggaccacg ctcgtgccgc
     1621 cgcgggagcg tcccgtgccg ggctccgggg gatccggcgc tcaggcgtcg acgacgagcc
     1681 agccgccgtg gtggtcctcg acgcggtagg gccggccggt ggcggcgccg agcgcgtcga
     1741 gcgcggcggc gtcgaacgtc cggacgtggc cccaggcggc gttgggctcg tcctcgtagg
     1801 gcaccgcgac gaccacccgt cgccgggcca ggcgcagcat ctcgccgacg acgaccgggg
     1861 cgagcgcggg cggcaggtgc tccagcaggt gcacggcgaa gaccgtgtcg gcgctgtcgt
     1921 cggccagcgg cacggcggtg gcatcaccgg tgagggtgtg cagcggcagg tcgagggcgg
     1981 gcgcgacgcg ggagagcagc cggaccgtgc ccgccgagag gtcgacggcc gtgacctcgt
     2041 ggccggccgc gacgagctgc agcgacagga acccgaagca gcaccccagc tccaccaccg
     2101 acccgagcgc gagctcgacg gcgcggtcgt gcacgggcgc catcccggcg ttcgtgccgc
     2161 cgggggcgcc tccgcggccc agctcgtcga gggtgttgcg gtagaacgcg gtccagcccg
     2221 ggtcgaccga cgcgacgacc gagacgaacg tccgctcgaa cgccgacgcc tcgatgtgcc
     2281 cgggcgcgac gaggtcgtcg gcgatccagc ccgcgaggtc gttgctgatc tcgcccgggc
     2341 cgatgcggtg ccggagccgg ccgtcggcgc ccatcgtgag ccggggcgcg gtggcggtgg
     2401 tcatcgtcgg agcctaggcg gcgggggccg cccggagcac ctgccggaac ggtcaggccg
     2461 tcggcaccgc ggccttcgac ccggcccggt gcggcccggc cccgtcgcgg gccccgtcgc
     2521 cgtctccgtc ctcgtcgtcc tcgtcgtcct cgatgcggtc gccgtcggcg gcgttccgct
     2581 cccgcaccgt gagcggcacg agcacccaca gcgtcaggaa cacgacggcg gcgacggcgg
     2641 cggcggcgat cccggccagc ggcccggcca ccacctcgaa gatcaggtcg atgaccgtga
     2701 cgacggccag cccgagcacg atgagcccgg ccacggcgaa ccgctgaccg gagcggacga
     2761 gcggccgccg cgcgttgcgc cggaacagca cgcggtgcag gacgaccggc gcgatgagca
     2821 gcgccgtcgc cgtggccgac aggctgatcg ccaccaggaa cacgacgcgc tggtgggcca
     2881 ccagcgcgtc gaaccgggcc tggaacggca ccgtgagcag cagcccggtg agcagctgca
     2941 ccccggtctg cgcgacccgg agctcctgga ggaggtcgtc ccagttgcgg ttcaggcgct
     3001 ccgtagcgct gcccgtgcca cccatgcgga cctccttgcc ggacggcgtc gtcgccgtgg
     3061 ccggaatagt cccccgtggg gccggtcgtc cggtacgggc gatcgggtga cccgtcaggc
     3121 cggcggcacc gccgtcgccg ggtcgccgtc gagcgccgcg gccaggcgcg ggcgcatctc
     3181 cgccagcgcg acgggcaggc tcaggaccga cccgaaggac agcgcgccgt tggtggtgct
     3241 ctgctcgggc agcaggatcg cccgcccctc gcgcgcgacg cgcaggttcc cgaacaccgg
     3301 gtcgtcgacg gtgccggtgg tggcgaacgc gccgtagagg ccgaggacga gcacgtcggc
     3361 gtcgagcacg ccgagctgct cggggctcag ctccaccggc ggccggtccg ggccggtgaa
     3421 cagggcctcg gctgcgggtg ggagagcgag gccgaggtcg gccaggaacg cgggcgcggg
     3481 gccctcggcg taggcgtagt aggtgccgtc ctccagccgg gcggcgagca gcccggtgcg
     3541 ccctgcgggg atcgtcgacc gcaggtcggc gaacccctgc tcgaccggcg ccaccagcgc
     3601 ggccgcctgc tcctcgcgcc cgagcgcggt gccgacgacc tcggtgatca cctgccacgg
     3661 ggcgccgtag tcggcgtgcc cgacaggcgg gccgacggtc ggggcgatcg cgctcagcgt
     3721 cgcgtactcc tccggggtca tcgagtagtt gacgcccagg accaggtcgg gcgcgagcgc
     3781 ggcgacctgc tcgtagctcg gctcggtcac cgccagcacc tccggcacgc cgtcggcgcg
     3841 ctccgcggcc cacggccaca gggcgcccgg gcgcccgccg aaccactccc gcaccccgac
     3901 cggggtgacg ccgagcgcga gcacgtagtc ctgctcggtg agccccatgg tcacgacccg
     3961 ctgcggggta ccgctgatct cggtggtgcc gagcttgtgc gtgatcgtgc gggtgctcgc
     4021 ctgcggcggc gcggtggtgc cgcccgcgca gccggcgagt gcggcgccga gtcccagtgc
     4081 tccggcgccg gtgagcagcg aacggcgggt gatcacgtca ggcagaggta gcggtcggtg
     4141 ccgtcgacgt cgcggccgcc cggcagccag cggtgcagca gcggggcgtc cgccacggcg
     4201 tcgacgggtc ggaaggtcgg ctcgggcacg gggcctcctc taggtggtag gacgccctaa
     4261 cttaacccag cctgccctca cccaataggg gtggggcggt gtgcgagcgc gccccccggc
     4321 ccgccgatca gcgccccacg agctccgccg ccatctcgtg cgccgcggtc tccaggccgg
     4381 agaggtcgcg gaccacccgc acccgggagc agtactcggc gtactcgggc aggtcgcacg
     4441 caccgaggcc ccacgagtag cggggctccg gggtgagcca gatcgtctcc cgcgcgcgac
     4501 gggtgatctc ggcgaacgcc tcggtgttgg ggtcgttgcc gttgccgcgc ccgtcgccca
     4561 ggacgatcac ggtggaccgc cggttgacgg ccgaggcgta ctcctcctgg aacgtgccga
     4621 aggccttgcc gtagtcggag ttggcgtcca cgtcgaggac gtcgccgccg aagatcaggc
     4681 ccagggcctg ctcgacgggg tggtcctcga acaggtcggt gacctcgacc atgtcggcca
     4741 cgaaggcgaa cgcgcgcacc tggccgaaca ggttctgcag cccgtggacc aggtgcagcg
     4801 tgaaccgggc cgttgcccgc accgacagcg acacgtcggc caggatcacc agccgcggct
     4861 tgtcctccga gcgcgtgacg gtgatcgggg agaacgggat gccgtcgaag cgcatgttgc
     4921 ggcgcatcgt gcgtccggag tcgatgcgcc cgcggctgga gaccttgcgc ttgtgcgtca
     4981 gcccgccgtg cagcgtgtgc gcgagccggc ggatcgactc ctcgagctcc atccgctcgt
     5041 gctccccgac gcggtcgacc tcgcggacct tctccgcctc cgccccctcg acgaccttgt
     5101 tctccagcgc catcagcgcc tcgaggtgct tcttgagcgc ctcggggagg ccggcgagca
     5161 cgccggtcat gcggcggcgc agggccgcgg cgtcgtcctc ggtgccgtcc tgcgactcgc
     5221 cgtcggtgga gttcagccag cccagcagca tctcctgctg cgcgaccgac aggtcggcgt
     5281 cgaccttcgt gccctgctgc tgggagatgt cgccgggcat gccggcgttg tgcaggctgt
     5341 cggtctcgat ctggacgcgc tggccctcgc cgtcgatgcc ctggctgtcc ttggacagca
     5401 cgatctcgtc ggtcatcgcg gccatgtcga tcttgttggc ctcctggtgc aggttgtact
     5461 gctgcgccag gtcgtcgggg tcgaagtagt cgcggatgtc ggccggcttg ccgtgctcgt
     5521 ggccctgctc gggggtgttg ctcggctcct ccgacagcgt gaacgactcg agctcgccgg
     5581 tgtcggagag gtcgccgtgg ccgtgcccgt ggccgtgccc ggtcgcgtcg tcaccgacct
     5641 tcaccagcgc gaagaagcgg tcgaagatgt cgtcgaagac ctcctcgtcg cgccggtcct
     5701 tgaccagtgc gacgcgcagg gcggcgcgga gctgctcctt gtcggccatc atcccgggct
     5761 gcgcggcgca cgccatcgcg tcgagggcct cggggatcga gatgcgcatc ccgcgcagcc
     5821 gcaggagccg gacgaagcgg tgcagcgcgt tctccatcag tgcacctccg gtgctcgtga
     5881 gcggcgatcg tggccagggc cgcggtcgcc gctcacgggg gtggtcacag cgcgcgcttc
     5941 cggcccaggc ccgcgccgaa gctgcgggtg ccgcgctcgg cgggcacctt gggcggggtg
     6001 atcggcttcg cgccggtgtc gccgccgagc gggttgctgc cgtaggtgtt gccgaagcgc
     6061 ccgggggtgt ccttggccgc gcgcaccgcg cggcccccgt cgtcctcgtc ctcgtcgtcg
     6121 tcacgcgcgg aggactgccg cgacgccggc gcgggcgcgt cctggtcgtc gtgcccgtgg
     6181 ccgtgcccgt gaccgtgtcc gtggcccttc tcgggaacgg tggcgttcgg gtcgacgagc
     6241 gtcggcagcg cgccgatcgc cttgcgcacg tccttgtcgt acttgacgac gaccgagacg
     6301 gtgtcggaca ggatcgtcgc gttgagctcc tcgacgccca gcacggcgag cgtgcgggcc
     6361 cagtcgatcg tctccgagat cgagggcgac ttgcgcagct cgagctggcg cagcccgcgg
     6421 acgatcccga cgagctgctc ggcgagcgcg tccggcagcc cggtcttctt gctccggacg
     6481 atctccagct cgcgctcggc ggtggggtag tcgaggaaca ggtgcaggca gcggcgcttg
     6541 agcgcggccg acaggtcacg ggtgttgttg ctggtcagga cgacgtaggg cggggtcttc
     6601 gtggtgaagg tgccgacctc gggcacggag acctggtact cggccagcgt ctccagcagc
     6661 accgcctcga gcgcctcgtc cgcgcggtcg acctcgtcga tcagcaggac gaccggctcg
     6721 tcggagcgga tggcctccag caggggacgc gaggcgagga agcgctcgga gaagaacacg
     6781 ctctcctggg cgccgatgcg gtcgaccgcg tcctccagcg tgggggcgtc ggcgacgacc
     6841 tggccgatct tctcgcgcag gatctgggtg tagagcagct gcttgccgta gtcccactcg
     6901 tagagggcct tggtctcgtc ctggccctcg tagcactgca ggcgcagcag gcgccggccc
     6961 gtggccttcg cgagcgcctt ggccagctcc gtcttgccga cgccggccgg cccctcgatc
     7021 agcagcggct tgtcgagtcg gttgaccagg aacacggtgg tggcgaggcg gctgtcggcg
     7081 atgtagccct gctcgcccag ggcgtcgacg acctcgtcga cggaatcgaa ctgtccagtg
     7141 ccggactcga acacgcgctg ctccgatcgt gactcgcgtc aggggcgccg gccacggccg
     7201 gcgcccctga tgactgtaag cggggtgact caggtgagca ggtcgtccag gtcgccgttc
     7261 atgcagtggt cgaccacggg gcgcaccgtc tcgaaggtgc actccttggg gttgcccggg
     7321 gtgcaggcgt cgccgaggac gtggttggtg atgcggtcga cgtccgccgc gtcacccttg
     7381 atgatcgact cgttctcgta gaacttcgtc gggccctggc ccagccggtt cttggagtac
     7441 gagtcctgct tgacgtcgac gaagcgctcc gggatgccca cgtcgcgcag cagccggatg
     7501 gacgcggcga gcgcggcctc ggcggcctgg acgtcggtca tgccgtgggt gtcgacgccc
     7561 atggccgagg cgatgtcggc gaagcgcttg tagtgcaccg gcatgttgaa cgcccacacg
     7621 cgcgggagcg cgacggcgtt gttgaggccg tggtgggtgt cgtagaacgc cgacaccgcg
     7681 tggctgatcg agtggatgat gcccaggcca ccggagttga acgcctgcgc cgcgatgtac
     7741 tgcgcgttca tcatgccctc gcggcccgcg taggactgcg ggttccacac ggcctcgcgc
     7801 aggctgcgcg cggtgagctt gatggcgtgc agcgcgttgc ccagcgacgg gtcgaagttg
     7861 atgcgcgaga cgtagggctc cgaggcgtgc gcgagcacgt cgaacccgca ctgcgcggtg
     7921 tagtcgaccg ggcaggagta gtagagcacc gggtcgtcga tcgccagcgt cgtgaccgag
     7981 gagtcgtcga acgccacgta cttgtggggg ttgtccgggt ccgtcgtggt gtcggtgatg
     8041 acgtaggccc acgaggtctc ggaaccggtg ccggccgtgg tcgacaccgc gatgtgcggc
     8101 gggttcttcg ggttctcgga cttgttgaag ccctcgaact cgttgacgtt gcggccgtcg
     8161 tgcgcgaccg agacgcgcgc gcccttgcag gcgtcgtgcg atgagccgcc gccgatggag
     8221 acgaagctgt cgcagttgtt ctgctggtag aggcccacag cgtccatgac gttgtagtcc
     8281 ttggggttcg actcgacctt gtcgtacacg acgacctcga ggccgtggta cttcatcgac
     8341 tcgacgatct tgtggacgat gtcggagccg cgcaggcccg acgtcatcac cagcgtcttc
     8401 ttgaagccca gcttgagggc ctccggaccg atcagctcgt gcgcccccgg acccatgagc
     8461 gcccgcggga acgggtggaa ctccttgatc gggaactgcg ggagcatctc ttcgacctgc
     8521 atggcagccc tttctgcgtg cgggtgtgtc gccgcgacgc taggacccgt gtggtcccgg
     8581 gcacaggaaa accatgagga gggacggggg tagcccgtct gatcgggtag ctgacccccg
     8641 cctccggccc cggccaggca ggtgcacaac tagtgcgaca gggtggcctc agtacgacag
     8701 ggtggcctgc cacgcgcggg ccacctcgcg gaagccccgg cgggcgtacc agtgccgggg
     8761 gtgcgcggcg gcgtcggcct cgagcaccac gaggtcgcag cccgcgtcgc ccgcctgcgc
     8821 cagcgcctcg gccagcagtg cgtcgccgtg gccgcggcgg cggtgcgcgg ggtcggtctc
     8881 gacggcgtcg agcacggccg tcgccccgtc gacctcgagc accgccgccg cgacgacggc
     8941 cccgtcgtgc tcgaccgcca ggcaccgcag gtcgacgacc tcggcctcgc gcagccagcg
     9001 gtcggacagc tgggccaggg actccgcgtc cacgtcgggg accgcgcggc gccacgcggc
     9061 gtcgcggaac gggcgcagct cgtcggggtc gacggtgcgc acgccggggg aggaggggcc
     9121 gcccgccgga gcggccatca cggtcagcgc gccgacggtg tggccggccg cggcgagcgc
     9181 ggccgcggtg tcctccaggt ggtcgccgac cagcagcgcc gcaggtcggg ggcggtcgcc
     9241 caggacgcgg gcggcgtcgg cggccaccgc cgcggcgtcg gccggcccgt tcacgagcag
     9301 ctggttgtgc tggttcgagc ggggcaccga cgccgtccgc accgcgatcc cgcccgtcac
     9361 cggctcctcc gacgtggcgg tgcggcgcag gaccgacgtc agcaccgcga cggcgcggcc
     9421 cgcggcgtcg agcgcgggga gcaccggggc cgtgaactcc ggccggtagg gcaggaccgc
     9481 cagcaccgcc gacgccggca ccgggccgta ggcgtgcggg aacagcatcg aggcggggtc
     9541 ggtgggcagg ccgggctcgt accggacctc gacgccgatc cgcgcggggt cgagcacgag
     9601 caggttcacg tcggcccgcc cggcgaacag ccgctgcgcc gggagggcca cctggtcggg
     9661 cccggacagg tgcacgaact ccgcgacgga cgggcggacc tccccgcgcc cgaggtgcgt
     9721 ccgccattcg gcggtggtgg cgaggtgcag caggacgtcg gtcacgggag cgatcctccg
     9781 cccccctccg atcggagggg ccggggtggt cgatcggcgg gcgggtcttg tctttggcac
     9841 ccggtgccac ttagcgtcgt cggcgtccgc atcgctcgac gacaggagcc gcccatggcc
     9901 cccgcacccg acgcccagtc cgcccccgag gagcccgtgg tcgaggagac cctcgtcgaa
     9961 gaggtctcga tcgacggcat gtgcggtgtc tactagcacc gtggcggctg cttccgacgc
    10021 cgggtccgcg caggccgcgg acccggcgtt cgacccctcg cagccgttcc gctgcagccc
    10081 gagcgtggcg ctgcgccccg agcccttcgg cgcgctggtc taccacttcg ggacgcgcaa
    10141 gctgtcgttc ctgaagacgc tgccgctcgt cgaggtcgtc cgcggcctgg agcaccaccc
    10201 cgacgtgcac gccgccatcg aggcagcggg cgtcgaggag tcgcagcgtc ccgcctacct
    10261 ccgtgcactc gccggcctgg ccgccagcgg cacgatcgaa ccccgcccca ccacctgagg
    10321 gtccacgacc ctcgaagagc ggagctcctg tgaagctggt cgaccacttc cagtacggcc
    10381 tgaactcccc gatctgcctg acctgggagc tcacctacgc ctgcaacctc gcctgcgtgc
    10441 actgcctgtc gtcctcgggc cgccgcgacc cccgcgagct gaccaccgcc gaggccaagg
    10501 gcgtcatcga cgagctgcag aagatgcagg tcttctacat caacatcggc ggcggcgagc
    10561 ccacggtccg gcccgacttc tgggagctgc tcgactactc gatcgaccac aacgtcggcg
    10621 tcaagttctc gaccaacggg atcaagctcg acaagcagcg gtcgcagcag ctcgcccgca
    10681 ccgactacgt cgacgtgcag atctcgctcg acggcgccac cgccgaggtc aacgaccacg
    10741 tccgcggccc cggctcgtac gacaccgcga tccgcgcgct ggagaacctc gccgaggccg
    10801 ggttcggcca gccgaagatc tccgtcgtca tgacgcgcca gaacgtcgac cagctcgacg
    10861 agttcaagtc gatcgccgac aagtacaacg cccagctgcg gatcacgcgg ctgcgcccgt
    10921 cgggccgcgg cgcggacgtg tgggacgagc tgcacccgct gccctcgcag cagaagcaga
    10981 tgtacgactg gctcgtggcc aagggcgact cggtgctcac cggcgactcg ttcttccacc
    11041 tctccgcgtt cggcgaggcc ctgcccgggc tcaacctgtg cggcgcgggg cgcgtggtct
    11101 gcctgatcga cccggtcggc gacgtctacg cctgcccgtt cgcgatccac gagaacttcc
    11161 tggccggcaa cctgcgctcg ccgggcggct tccaggagat ctgggagaac tcggagctgt
    11221 tcaccgagct gcgccagcct cagaccggtg gtgcctgcgc ctcctgcatg cactacgact
    11281 cgtgccaggg cgggtgcatg gcggccaagt tcttcaccgg cctcccgctc gacgggcccg
    11341 acccggagtg cgtccgcggg ttcggcgagc aggcgctggc ggcgcgcgac ggggtcgaga
    11401 tcccgaagtc cgacgtcgac cactcgcgct cggcgccgcg gaactcccgc acgcccaagg
    11461 ccccggtgat gctgcagatc ggcatgggcc gccccgacaa gtcgtgcgac ccgagcccgc
    11521 tcgcggcgcc cgcggcgctg acgcaggcgt cggcgcgagc ctgagcggcc cggctctctc
    11581 cgacgaacgg cactctcgcc cagcgagctc gggcgagagt gccgttcgct cgttggccgg
    11641 gcccgtcgtg ctgcgcgggc gcaccgcccc gtcgcgcgtg ctgttcggcc cccacgtcac
    11701 caacctcggc caccggcgct cgctgtcgcc gcggcacgtc gcctactacg cgcggcgggc
    11761 cgccggcggg gcgggcgtcg tcgtcaccga ggcggcgtcc gtgcgcgact ccgaccaccc
    11821 ctacgagcgc gccccgctcg cggccgactg cgccgacggc tggcgcgccg tcgccgacgc
    11881 ctgccgcccg cacggtgcgc tcgtgctcgc cgggctcggc cacgccggcg cgcagggctc
    11941 ctcggcctac gggcagcggg cgctgtgggc cccctcccgc gtcgccgacg tcgcctcgcg
    12001 cgaggtgccg atggcgatgg agcagcccga ggtcgacgcg ctggtggccg ggttcgccgc
    12061 ggccgccgcg ctcgccgtcg acgccgggtg cgacggcgtc gagatcggcg ccgggcagca
    12121 ctcgctgctg cggcagttcc tctccgggct gaccaaccac cgcaccgacg cccacggccg
    12181 cgaccgcgcg ctgctgctgc gcgaggtgct caccgccgtc cgggccgcgc tcggtgagga
    12241 gcccgtgctg ggcctgcgcc tgtgctgcga cgagctcgcg ccgtgggccg gcatcacgcc
    12301 cgactcggcc gcggagaccc tcgccgcact cccgcccgtc gactacgtcg tgccggtgcg
    12361 gggcagcggc ctctccgtcg gcgccacccg ccccgacctg cacaccccgc ccggcttcaa
    12421 cactttgctc tgcgcactca tacgcaccgg ctcgtccggt gcgtatgagt gcgcagagca
    12481 aagggcagag caaagggcag agcacagggt ggtgctgcag gggtccgtgg tcgacccggc
    12541 gatggcgcag gccgccctcg acgacgggct gtgcgacctc gtcgagatga cgcgcgccca
    12601 gatcgccgac cccgacctcg tcgcccacgt ccgggccggg acaccggagc ggatccgccc
    12661 ctcgaccctg tcgaaccgcc gcaccgccgt gcgcgacccg cgcaacccga tcgtctccga
    12721 cgacgccgag cccgacgccg ggcacgagac ggagccggtg cccgcgccgc ccggaccgcc
    12781 gcgcgacgtg ctcgtcgtcg gcggcgggcc ggccgggctg gaggcggcgc gcgccctcgc
    12841 gctggccggg caccgggtgc ggctcgtcga gcgggagccg gtgctcggcg gggcgctgcg
    12901 gctcgcggcg gccgtcgccg ggcgggcgcg gatgggggtg ctcgtgccct ggtgggagcg
    12961 tgagctggcc cggctcgggg tccgcgtcga gaccggggtg acggccgccc cggccgatct
    13021 cgtcggcccg gtcgtgctcg ccaccggctc ccggcccgcg cccctgacct accccgccga
    13081 cgtggcggtg ctcgccgccg cggagttcga ggcggccgtg ctcgccggcg ggcccgtgct
    13141 gccgccgggt cccgtcgtcg tccacgaccc ggtcggggac tggacgggcg tcgggatcgc
    13201 ggagcagctc gccgcggcgg gccggacggt cgcgctcgtc acgcccgacc ccgtcgcggg
    13261 cacccagctc gcgctcaccg gcgacctggc ccccgccaac gcccgcctcg accgcgcggg
    13321 cgtgacgcgc gagcggtacg cccggctcgt cggcgtcgcc gggggccggg cggagctgga
    13381 gcacgtgtgg accggccagc ggtgggacct cgcctgcgcc gcggtggtcg actgcggcca
    13441 ccgcctcccc gccgacgcgc tgtggcgcgc ccgccccgac ctgccccgcg cgggtgactg
    13501 cgtggcgccc cggacggtcc acgaggccgt gctggagggc cgccgggcgg cgtacgaagc
    13561 ggtcacgggg ctgccgtgct gaacgagccg ctgcaggtgg ggcccctggt gctgcgcaac
    13621 cgcctcgtct tccccgcgca cctgaccaac tacgccgtcg acggcctccc gaccccgcag
    13681 cacaccgcct actacgccgc gcgggccgcg ggcggcgccg gtctggtgat caccgaggag
    13741 cacggcgtcg acccgtacga ccggccctac gagaagctca tcgaggcccg cgacggcgcc
    13801 ctgcccggct accgcgcgct caccgccgcc gtgcacgcgg agggcgccgc ggtgctcgcg
    13861 cagctcaccc acaacggcgg gcagtccagc ggcatgcaca gccgccggcc ggtgctcgcg
    13921 ccgtcaccgg tgccggaccc gctgttccgc gaggtcccgg tcgagctcga cgccgcgggc
    13981 atcgcccgga tcgtggacgg ctacgcggcc accgccgccc ggtgcgtcgc gggcgggttc
    14041 gacggcgtcg aggtgcaggc cgcgcactcg tcgctggtcc ggcagttcct ctcgccgctc
    14101 accaaccgcc gcaccgacgc ctacgggcgc gaccgcaacc ggttcctgct cgaggtcgtc
    14161 gacgccgtgc gcgacgccat cgggcccgac cgcgtgctcg gcgtgcggct gtgcggcgac
    14221 gaagggcccg cgcacaccct gggcgcccac ggcatcggga tcgacgacgc cgtcgccacc
    14281 gccctcgcgc tcgccgggcg cgtcgacctc ctgagcaccg cgatcggcgt cgccacctcc
    14341 acgctctacc tggtcgaggc gtcgctgcgg ttcgcgccgg gctacgcgct gtcgatcccg
    14401 gaggcgatca ggcacgccgt cgacgtgccg gtgatcggcg tcgggcggtt caccaccccc
    14461 gcgcaggccg agaccgcgct ggagtccggg cgctgcgacc tcgtcggcgt cgtccgcggg
    14521 cagatcgccg agcccgcgtt cggcaccgcg ccggtgcggg cgtgcgtggg gtgcaaccag
    14581 gagtgcgtcg ggcgggtggg gcgcaaccgg tggctgggct gcgtcgtcaa cccgcgcgcg
    14641 ggccgcgagt ccgtgccgct gcccgcgccc ggcgtcccga agcaggtgct ggtggtcggc
    14701 ggcggaccag gcgggctgcg cgccgccgcc accgccgcgg cgcgcgggca ccgggtcgtc
    14761 ctgtgcgagc gcgacgccac gaccggcggg gccgtgcggc tcgccgccgc cgcgcccggc
    14821 cgcgccgagt tcgcgaacgt ggtgcgcgac ctgctcggcg agtgccgggc ggcgggcgtc
    14881 gaggtgcgga cgggcgtgga cgtcgacccg gcgctggtgg aggccctggc gccggacgcc
    14941 gtggtgctcg cgacgggcgc gcggccggcc gcccggtggc ccgtgcccgg ggtggtggac
    15001 gtgcgcgacg tgctgtccgg gagggtggca cccgtgcgga acgcgctcgt gtacgacgag
    15061 ctgggcttcc accaggcacc cgccgcggcg gagtggctgg cggcgggggg aagtggcgtg
    15121 gagctgatga cgccggggct ggtggtcgcg caggacctcg ggacgacgct ggacgcggag
    15181 ctgttccacc ggcgcgcgca cgcggcgggg atcgtgctga cgaccgaccg ggtcgtcacc
    15241 gggatcgcgc ccggccccga gccggccggg ccgctggtgg tgacggtgct gcaccacacg
    15301 accggcgccg aggagcgtcg cagctacgac ctcgtcgtcg cggtcgtgcc gcccgagccg
    15361 gacgacgccc tgtgggccgc gctgcgcgac gggccgcgcc cggtgcaccg cgtcggcgac
    15421 tgcctggccc cgcgccgcgc gcacgccgcc gtcgtcgagg gcgaccgcgt ggcggtgggg
    15481 ctgtgacggc gctgcggctg ggcgagcgca cctggaccga cctcgacgag ccgcggacgg
    15541 tgctggtccc cgtcgggtcg ctggagcagc acggcccgca cctgccgctg gacaccgacg
    15601 cccgcatcgc cgcggccgtc gcccgccgcg ccgccgacgg cgacccgacg ctgctggtcg
    15661 cgccgcccct ggcctacggg gcgtccggag agcacgaggg cttcgcggga acgctgtcga
    15721 tcgggcacga ggccctgcgc gcggtgctgg tggagctggg gcgcagcgcg gcgcggtggg
    15781 cggcgaggct ggtgttcgtc aacgggcacg gcggcaacct cccgaccgtc cccgacgccg
    15841 tcgcgcagct gcgccacgag gggcgcgagg tggcctggtt cggctgcgcg gtgccccgcg
    15901 gcgacgccca cgccgggcgc acggagaccg cgatcctgct ggcgctcgac ccgtcggtgg
    15961 tgcgtcggga gtcgctggag ccgggcaaca ccgccccgct gcgcgacctg ctgcccacgc
    16021 tggtccgggg cggggtggcc gcggccagcg ccaacggcgt cctgggcgac ccgcgcggcg
    16081 ccaccgcccg ggagggggag gagctgctgg aggagatggt cgggcagctg cgcgagcgcc
    16141 tcacccgctg gctccccgac gaccgcggcc gcctgggctg accgcgaggg ggcagatcgg
    16201 gcccgatgag ttccggccgc gacggcggtc ggtcccggca tgagcatcgt gagcagtcac
    16261 ctcaccgtct ccctcgacgg cttcgtcgcc gggcccgacc agagcctcga ggagcccctc
    16321 ggccgcggcg gggagcgcct gcacgagtgg atgttcgtgc ccgacggccc ggagtccgac
    16381 gcccgcatcg tcgaggagtc gctcagcggg gtgggcgcgt tcgtcatggg ccgcaacatg
    16441 ttcgggcccg accgcgggcc gtgggacccc tcgtggacgg gctggtgggg cgaggacccg
    16501 cccttccacg cgccggtgtt cgtgctgggc caccgggagc gggagccggt ggagatggcg
    16561 ggcggcacga cgttccactt cgtcaccgac gggatcgggg cggcgctcga gcgcgcgcgg
    16621 aaggcggcgg gggagcggcg cgtcgacatc gcgggcgggg cgagcacggt gcgccagtac
    16681 ctggccgcgg gcctcgtcga ccggctgacg ctgcacctcg tcccggtcct cctcggatcg
    16741 ggggagcggc tgttcgacgg cctcgacggg ctcgtgctgg agcaggagga ggtcgtcgtc
    16801 tccccggcgg tgacgcacct gcgctaccgc gtcgcccgct gagagccggc gctacgacct
    16861 gaccagcagc agcggcacca gctgctcggc cgtggtgagc gagccgtgct ggcccggcat
    16921 ccgggagatc agcggctcgg cctcggaccg gatgaccgcg gccgtgccgc gggtggcgac
    16981 cacgacgtcg ccgatccggc tgcgcatcgc cggggcgacc ggcccgaacc agccgtcggc
    17041 cgcggcctgc tcgcccggca ccacccacgc gtcgtcgccc aggacggcgc gccacgcggc
    17101 caggacctcg tcggcggcac cggggcgggc gtagacgtgg cgggcgcggg cgtcgccgcc
    17161 cagcagcagg acgccctggc gcagggcgtc gtcggtgtcg gcgtcgtgga tgcggtcgac
    17221 cgacaccatc ccgtggtcgc cggtcaccgc cagcacggcg cccggcggca ggtcctcggc
    17281 gatccgctgc acgaggcggt cgacctgcgc gagctgcatc cgccaggcga cgctgccggg
    17341 gccgtgcagg tggcccatcg cgtcgaggtc ggcgtggtag ccgtagcaga gccgccgctc
    17401 cgggccggcg agcgcggcga gcacctcggc ggcgaggtcg cccagcgcgt gcgtgccgcg
    17461 gaaccggccg ccgcgcagtg ccgcgcgggt cagccccgac ccgcggaaca cccgctggga
    17521 cacgaccgtg accccgatgc cggccgcctc cgcccgctcg aacgccgtcg gggacggctg
    17581 cacctgctcg ggcaccagcg cctcgcgcag gtcgacggcg tcgccggcgc cgtgggaggt
    17641 ccacttcagc gagtcgagca gctcgccccc gacgcggaag gagatgccca ggacgccgtg
    17701 cgcgcccggc ggcagtccgg tgccgaccga ggtcagcgag atggaggtgc tggacgggaa
    17761 gccgacggtc accgggccgg cgtcggccat cgacgacagg aacggggcgt cggccgcgtg
    17821 ggcgtcgagc agctcccgac ccagcccgtc gaccaggagc agcgcggcgg cccgcgccgg
    17881 ctcgacgacg aggtccgact ccggttccgg caggcccagc gcgcgcagca gcgcgggcag
    17941 cacctcggcg agggagcggt ggccgtagag cgggagcggg aacacgggtg gagcgtgcca
    18001 gacacgccct aggctcctgc catgcacgga acgcccgtcg gtgacgagca cgccggggag
    18061 cagggccccg ccagcacggt gctccccgag gggctccggg tggcgctcga ccgccgcacc
    18121 cgaagcgtcg acgacggcgc ggtgctgctg ggcggggcgc ccccgcggat gctgcggctc
    18181 gcccgggccg ggcgcgacct gctggcgccg ggcgcgttca ccgtcgacgg gccgacctcg
    18241 cgcgcgctcg cccgccgcct gctcgacgtc ggcatcgccc accccgtcgg cggtccggcg
    18301 gggccggggc cggacgcggt caccgtcgtc gtgccggtga aggaccgcgt cgacgggctg
    18361 gcgcggctgg tggcggcggt cggcgaggtc ggcgcgctgg tcgtcgtcga cgacggctcg
    18421 gccgaccctg cggcgatccg ggcggcggcg ggcccgcggg cgcgggtgct gcgccacggg
    18481 cgcagccgcg gtgcctcggc cgcgcgcaac accggcctgc gcgccgcgtc gacgccgctg
    18541 gtggcgttcc tcgactccga cgtcgtgccc gaaccgggct ggctcgcgcc gctgctggcc
    18601 gtgttcgccg acccggcggt ggcgctggcc gcgccccgga tcgtcgccct cgcgccggtc
    18661 gtcggctggc tcggccgcta cgaggccgtg cactcctcgc tcgacctggg gccggacccg
    18721 gcgctcgtcg tcccgcgctc ccgggtcgcg tacgtgccga gtgcggcggt cgtggtgcgc
    18781 cgcgaggccg tgggcgacgg gttcgacgag gcgatgcacg tagccgagga cgtcgacctc
    18841 gtcctgcgcc tgcacgcggg cggccaccgc ctgcgctacg tgcccgacgc gcgcgtggcg
    18901 cacgaccacc gcaccacgct gcgcgcgtgg tggtggcgca aggcgcagta cggcaccggc
    18961 gcggcgccgc tcgcgctgcg ccaccacggg gccgtgccgc cgatggtgct cagcccgacc
    19021 tcggccgccg tcgccgcgct ggcgctggtg gggcggccgt gggcgctggc cgcggcgggc
    19081 gtcgtcggcg cggtggccgt cgagcgcctc tcgcgccggc tcgacgtgcg ccgcccgcgg
    19141 accaccgccg cgcggctggt ggggctcggc gcgctgggcg cggtgtccca gacggccgac
    19201 gccgtgaccc ggcactactg gccgctgtcc ctggccgcct gtgcggtgtc gcgccgggcc
    19261 cgccgccggg tgctggccgt ggcgctggcc gagggcgcgg tcgactggtg gcgccaccgc
    19321 ggccgcgacg cgcgcgtgcg cccggacccc gtctcgcacc tgctcgcgca ccgcctggac
    19381 gacctcgcct acggcgccgg gctgtggtgg ggcgcggccg cgcaccgcac cgcggcaccc
    19441 ctcctaccct ccggaccagc cctccgggtt ggtccgaacg gttgattaag tcggtgtgag
    19501 gcgcccgctc ctgcggagtc gtggggtgat tcgttccgcg tctacggatc cgtacggaca
    19561 ggcgtccgac gagcgccgga cggcgcgctc caggccaggg tgagctttgt tgcgggcccc
    19621 gatgatcagc ggtgagatgt gggcgctgcc acaccggtgt ggtcggccac cacctaccga
    19681 cgtcgttgcc taggagaaga cacatggcac aggtccgggt caccgtcgac ggcgtgaact
    19741 acgccgacga cgtcgagccc cgtacgttgt tggtccacta cctgagggaa cgcctcggca
    19801 agaccggcac cctcgtgggg tgcgacacca gcaactgcgg tgcgtgcacc gtccacctca
    19861 acgggcagag cgtgaagtcc tgctccgtcc tcgcggtcca ggcggacggc gccgaggtca
    19921 ccacgatcga gggcatcgcc cgcgacggga agctgcaccc cgttcaggag gccttcaacg
    19981 agaagcacgc cctgcagtgc ggttactgca ccccagggat gatcatgcag gccatcgacc
    20041 tgctggggga caaccccgac cccgacgagc acgaggtccg cgagggcatc gagggcaacc
    20101 tctgccgttg cacgggctac cagaacatcg tccgggcggt gcagagcgcg gcccagaaga
    20161 tgaagcccgg cgcgcacgcc cagaccgacg ccccggtccc cgtggccggt ggaggtaact
    20221 gagcatgacg acgaccgctg atcccaccac gctcgagttc ggcaaggcgc gcacccgcaa
    20281 ggaggacgcg cgcctcatca ccggccggac caagttcacc gactccatca acctcaacgg
    20341 gatgctgcac ctgcacgtgg tgcgctcccc gctggcgcac gccaccatca ccggcgtcga
    20401 caagtccgcc gccgaggcct cgcccggcgt catcggcgtc tacaccgcgg ccgacctggg
    20461 tgtcgaggcc gtcggcctgc cctgcgcctg gccgatcacg ccggacatga aggccccgca
    20521 gcgcccgctg ctcgcgaaca ccaccgtgca cttcgccggt gagggcgtgg ccgtggtgct
    20581 cgcccgctcc gccgccgagg cccgcgacgc ggccgacctc gtcgaggtcg actacgagcc
    20641 cctcgagccc gtcctcaaca tggaggacgc gatcaaggag ggtgccaccc tggtccaccc
    20701 ggacctcggc accaacgaga acgccacctg ggtgttcgac tccggcgcgg ccggcaccgg
    20761 cgaggacgtc gccgccgcca tctccgcggc cgaggccgac cccgactcga tcgtcgtcaa
    20821 gcgccgcttc atccagcagc gcctgatccc cgccttcatg gagccgcgcg cgtgcgtcgt
    20881 cgacccgacc ggtgagcaga tcaccgtctg ggccgccacg caggtgccgc acatcctgcg
    20941 caccatgacc acggtgacgc tcggcgtccc ggagtccaag ctgcgcgtca tcgcccccga
    21001 cgtgggcggc ggcttcggcg gcaagatcgg cgtcctgccc gaggagatgc tctgcgtcgt
    21061 cctcgcgcag aagaccggca agccgatcaa gtggaacgag agccggtcgg agtccctgct
    21121 cgccgcgcac cacggccgcg accagatcca ggacctgacg atcaccgcca agaaggacgg
    21181 cacgatcacc ggcctggacg tccacctgct cgccgacatg ggggcctacc tcggcctcgt
    21241 cggcccgggt gtcccgatcc tgggcgcgtt catgttcaac gcgatctaca agatcccggc
    21301 gctcaagttc acctgcacca acgtcttcac caccaagacg ctgaccgacg cctaccgcgg
    21361 cgccggtcgt cccgaggcca cgttcggcat cgagcggatg atggacgagc tcgcggtcga
    21421 gctcggcatg gagccgatgg agctgcgcaa gaagaactgg atcacccacg aggagttccc
    21481 gttcaccacg gtcgtgggcc tgacctacga ctcgggcaac tacgagcagg ccaccgccca
    21541 ggcgatggag gccttcgact acgc
//
