LOCUS       NZ_JABBWV010000016     19728 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H11081 NODE_16, whole genome shotgun sequence.
ACCESSION   NZ_JABBWV010000016
VERSION     NZ_JABBWV010000016.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H11081
  ORGANISM  Microbispora sp. H11081
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 154154)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 154154)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Anotibioctics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012999535.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:41:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,738
            CDSs (total)                      :: 6,662
            Genes (coding)                    :: 6,604
            CDSs (with protein)               :: 6,604
            Genes (RNA)                       :: 76
            rRNAs                             :: 5, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            partial rRNAs                     :: 1, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 58
            CDSs (without protein)            :: 58
            Pseudo Genes (ambiguous residues) :: 0 of 58
            Pseudo Genes (frameshifted)       :: 7 of 58
            Pseudo Genes (incomplete)         :: 54 of 58
            Pseudo Genes (internal stop)      :: 2 of 58
            Pseudo Genes (multiple problems)  :: 5 of 58
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:04:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 134426
            Orig. end                         :: 154154
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBWV010000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..19728
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..19728
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..19728
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:12037](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12037
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    216..231
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.46"
                     /tool="antismash"
     misc_feature    682..696
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            complement(892..1713)
                     /locus_tag="HHX31_RS29300"
     CDS             complement(892..1713)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015272.5"
                     /locus_tag="HHX31_RS29300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="WP_169952228.1"
                     /transl_table=11
                     /translation="MPATPYGRAGSGDVLPPPRSFGEEGGRLSYGGYLRLPELLAQQER
                     RSGASDELLFITVHQVYELWFQLLLHELERIRDAMVEGALWRARHLFRRVHAVEKVMVD
                     QVQVMATMTPQDFLEFRSALAPASGFQSVQFRELEFLSGAKDPSYLGRLRDASDAELAR
                     LRRRLEEPTLWDAYLIALSQRGLPVSDEEIMESLLAVARDRGSYDDLWDLAEDLLTHDE
                     TTALWRMRHVQMVERQIGTKSGTGGSSGAPYLRGRTRLHFFPLLWELRAWL"
     gene            complement(1959..2951)
                     /locus_tag="HHX31_RS29305"
     CDS             complement(1959..2951)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012512.5"
                     /locus_tag="HHX31_RS29305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PLP-dependent cysteine synthase family protein"
                     /protein_id="WP_211590482.1"
                     /sec_met_domain="PALP (E-value: 4.4e-62, bitscore: 203.1,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAGIDERTGGVMGIVSGVLETIGNTPLVRLRGVVPPGCAEIFVK
                     IEGQNPTGSMKDRMAQAMIARAEDDGRLRPGDTVVEYTGGSTGASLALVCAAKGYRLSI
                     VSSDAFSEDKLIQMAAFGAELTLIPSEGGLITKSLILSMIETAEEFGRRRGTYWTDQLT
                     NTDSIAGYHAMGEEIWAQSGGRVDAFVQSIGTAASLRGASAPLKRRNPELRVTAVEPAE
                     SAVLSGCRPGAHRIEGIGIGYPPPMWDPALVDEIIPITTKDAEEMARRLAREEGLFAGT
                     SSGANVLAAIQVGRRLGPDARVVTLLVDSGLKYLSTGVYRRRAALRDES"
     gene            3038..3712
                     /locus_tag="HHX31_RS29310"
     CDS             3038..3712
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013777.5"
                     /locus_tag="HHX31_RS29310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="WP_169952230.1"
                     /transl_table=11
                     /translation="MSGYGQFCAVARALELLGERWTLLIVRELLLGASTFTDIRRGLPR
                     IPRATLAARLRALRAAGVLDGYRLTEAGAALAPVVRELARWAVATDSVALTENDLDTAA
                     LTWDMRRRVNATALPERTVVLAVEFTDRPPADRRYWLHLSSASVDLCRQDIGAPVDVWL
                     STPIAAATRWWLGDLSWAQLLRQPGVRVDGDRTLQRQMHRWFERYVFTPETLGLRQASP
                     SG"
     misc_feature    complement(3784..3799)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     gene            3858..5318
                     /locus_tag="HHX31_RS29315"
     CDS             3858..5318
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013714.5"
                     /locus_tag="HHX31_RS29315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_169952232.1"
                     /transl_table=11
                     /translation="MIDRRSFLRASALAGAGAFAGTGFTSAGPRPADWSALGRGLDGTL
                     IRPGDASYDNARRVFNSAFDSVRPTGVAYCRTAADVSECLAFARRHGVPVTSRSGGHSY
                     AGWSTGSGLVIDVSPMNGVSHSGGHATIGAGARLVDVYAKLAARGVSIPAGSCPTVGVA
                     GLTLGGGLGVVSRRYGLTCDVLESLKIVTADGKVLTCSPNSHPDLFWASRGGGGGNFGV
                     ATSFTFRTHPTRPVTLFFLHWLWSKASAVLKAWQAWAPAAPDAMWSNCHLGHDPSLDVM
                     VGGLYLGGKAACESLLHKLVDRVGSAPSNRYVAVSAYDHAMMVEAGCASMSVAQCHRPG
                     TLPGQNPSGRLVRDSFSAKSHFAYTPLSSAGIKALLAQVAAPGRHIVMLDAMGGAIGRV
                     RPDATAFPHRKALFSVQYFSHFAGAASWARAAHAAMRPHFGDHAYVNYVDPELKNWRQQ
                     YYGANAARLAKVKAAYDPGRLFRLPQGV"
     misc_feature    4611..4613
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5407..5904
                     /locus_tag="HHX31_RS29320"
     CDS             5407..5904
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022636.5"
                     /locus_tag="HHX31_RS29320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2975 domain-containing protein"
                     /protein_id="WP_169952234.1"
                     /transl_table=11
                     /translation="MRRLTLLALRAVLVALLAGSVFVQTVMVPLLASDLEGLDPEYAYL
                     RAPILALTVLGVAAVEVVLVCVWRLVTMVWRDTVFSHAAFRYVDVVIGAFVAAALLAFA
                     LGFLLAPGEAVPPGVVLLVGGVGVAALGVALVVLVLRLLLAQAVARDGEAARMQAELDE
                     VI"
     gene            5904..6119
                     /locus_tag="HHX31_RS29325"
     CDS             5904..6119
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013872065.1"
                     /locus_tag="HHX31_RS29325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_169952236.1"
                     /transl_table=11
                     /translation="MPIVVDIDVMLAKRKMSVGELADRVGITPANLAVLKNGRAKAVRF
                     STLAALCEVLECQPGDLLRWEAEDEA"
     gene            6300..7733
                     /locus_tag="HHX31_RS29330"
     CDS             6300..7733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541408.1"
                     /locus_tag="HHX31_RS29330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_169952238.1"
                     /transl_table=11
                     /translation="MPADVSHLIDELRAAGGDSTAIEVKSAAGGLPDSLTPTLSALANL
                     PGGGTIILGLDERFGFRPVPLPNAQSLKQGLAAKARSFTPPVRLTLDDGIAYGAPVIVA
                     RVHECDKSAKPCRVTATGASYLRGYDGDFRLSDIEEQAFIAARRAPMFDRTLVEGATSA
                     DLDPELVKAFLEAVRERDQQGLGRFVRDDELLCRAGVTAVDGRPTVAGLLALGTHPQQW
                     FPRYAIQISADPLPGDPPGSRARNQAVLSGPIPRMLDAAMEWARRTFDTAIVAGPDGTV
                     RDLPVYPLIAFRELVANALIHRDLDHWSAGMAVEIRLRRDRLVIANPGGLYGITVDRLG
                     KEAVTSARNARLVAICQNVRSPFSGGRVIEALASGIPTVGAALDEARLPPAHYIDAGIR
                     FVVILHRPIVATPAADPLNATESRVLDTLAQGTLTVAQLVEMLNLTAPNIRKALRGLRE
                     QGYVRQHGGRGKFTYYERA"
     misc_feature    complement(7824..7837)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.75"
                     /tool="antismash"
     misc_feature    complement(7835..7853)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            7875..8513
                     /locus_tag="HHX31_RS29335"
     CDS             7875..8513
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS29335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169952240.1"
                     /transl_table=11
                     /translation="MSRSRTYLACGLGAAGVAVLGLALSVVPSVAQGASGGERTRPVVN
                     PSPKQPGGHTVLTCAMSTGSAEPITAEPAVGKEARTVSARGVLTLTGCASPDGSFPNIR
                     SGKVTLQGSAQASCTGVQNVTGTGTVTWKDAQGQTLGTSTIRPNMDGIPSYNPGDMMLV
                     GEVVEGKLKGKRIAGKAVPTSDIGQCSAKGVSSVQGTGSVAFIAVGTPK"
     gene            8566..9192
                     /locus_tag="HHX31_RS29340"
     CDS             8566..9192
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017601374.1"
                     /locus_tag="HHX31_RS29340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_169952242.1"
                     /transl_table=11
                     /translation="MPSDEPVLRVRDVRKGYRGGPVLRGVDLDLPPGQVAGIVGENGAG
                     KTTLLRVLAGDLRPDGGSVRHRGRVGHCPQETVLHDAFTVEQHLRFFRVAYGMESLTRA
                     EELMEALRFSGSRRARPATLSGGTRQKLNLVLALMHDPDVLLLDEPYQGFDWETYVRFW
                     DLADELRARGRSVLVVSHLAYDAARLDTLHRLEGGVLRAAERTGA"
     gene            9192..9980
                     /locus_tag="HHX31_RS29345"
     CDS             9192..9980
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS29345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="ABC transporter permease"
                     /protein_id="WP_169952243.1"
                     /transl_table=11
                     /translation="MGRHWECYATAVRMTFVEHLRNRLALVIIVVFIPVWAVLIYALSL
                     EIALPFHVRAAERVVVLPANVLNQLAGALQILALITGFMMFVTTLHSASFDRRLVRSGF
                     PRLCLVAAKLTALVVVALCVAAYATGLICLTHRPAQPLLLAAALFGGALIYGGIGVVLA
                     AVLTSDLAGLVLVTVICSVDLALQSPLATPAAAGTVVRYLPDYGPMQGAVAAVALDTVP
                     WSAVAPAVCWALGTLALGVSAFAARTRVHRPVGGPAALSA"
     gene            10001..12037
                     /locus_tag="HHX31_RS29350"
     CDS             10001..12037
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PT_HPP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.5"
                     /locus_tag="HHX31_RS29350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_169952245.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.8e-50, bitscore:
                     162.7, seeds: 145, tool: rule-based-clusters)"
                     /sec_met_domain="PT_HPP (E-value: 1.9e-49, bitscore: 161.6,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="T1TS (E-value: 5.8e-43, bitscore: 140.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSETVARVFPALESDLERVREIVGLADVPSRAELTALTRQPAGH
                     RQLIRPTLTLLSYYLLAGPERAAHVRAVKAAAAVELLHMASLRHDDVIDGARQRRGGPS
                     VNSVWGARLAVLAGDLLFISGSRIVAELGEREALVSAEAVQLICSGMIAETADRFLLSR
                     TEEAYLEVTGAKTAELLSLACRLGAMQAGRDGEAEEAVARFGWHLGMAYQVRDDVLDLT
                     ATAGELGKPANSDMAEGVYTLPVIRALAREPALARLLRRGLTTADTEQARRLVLSCGAV
                     EEAGKVAGEHAEAAVARLRDVGDPRSREALAAYVRSVMGSVTGSGMGPVGQAGRDPVTV
                     PVSASVPLRGDDGLVRAVQERLDAWLLDSGLAATREESRHPRWSGMAAATALMWPGADA
                     EQLETLARWMLVCIVLDDLFDEPGLADPAEAARLRHRLALLIGGLDDAPPAGGAFATAL
                     AQAWERLRLTQPPSWRTRAIGHLLDWLDAAEREACHRLSGYVPSLRDQFPLRLGSAGIP
                     VFLDAFEISCGREFAPSVRDHPLLRRLLDLGSATVLAENDLRTLDQDEATGTPYNLVTV
                     LRHETGCTRQEAIDEVTRQVEDGYAQVDAILSSAPAILRPASGDADSVPVVAILRIVRD
                     RLAGWRAIHDVDRYSSSSAGGGTHLARLRRELLLEYAESGAAR"
     gene            complement(12055..12777)
                     /locus_tag="HHX31_RS29355"
     CDS             complement(12055..12777)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019606772.1"
                     /locus_tag="HHX31_RS29355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_169952247.1"
                     /transl_table=11
                     /translation="MSDPENETASGRDRTRAHIVSVAARLLASGGRDALSTRAVAAAAG
                     TQAPTIYRLFGDKDGLLDAVAEYGFGSYLRDKLASPPAGDPVEGLRAGWDLHVGFGLAN
                     PALFSLMYGDPTPGRQSPAAVAAFRMLGERIRAIAAAGRLRVGERLAADLVHAAGCGTV
                     FTLLAMPEERRDPRLSEVAREAAMAAITTDAPVVETPGPAAAAMALRAALPDATALTDG
                     ERHVLGEWLDRLATDRSG"
     misc_feature    12863..12878
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.47"
                     /tool="antismash"
     gene            12864..13703
                     /locus_tag="HHX31_RS29360"
     CDS             12864..13703
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017543344.1"
                     /locus_tag="HHX31_RS29360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_169952249.1"
                     /transl_table=11
                     /translation="MMIITGATGQLGRGVVDRLLARVPADRIGVSVRDVPRAGDLARRG
                     VRVRRGDFADPASLAYAFEGASRVLVVSGPADAGPHRTAIEAAKAAGAGRILYTSHMGA
                     NPASPFLPMPSHAETEHDLREIGVPFTALRNGFYATTALNFVSQALETGRLVAPEDGPV
                     SWTAHADLAEAAAIALTEDGRLDGVTPPLTGPESLDLADVAAIASELTGREITRVTVPD
                     GEWVAGMVSRGMPEQQARFLLGMFEASRRGEFAEAGPALGDLLGRKPAALRDVLANR"
     gene            complement(13750..14427)
                     /locus_tag="HHX31_RS29365"
     CDS             complement(13750..14427)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017605161.1"
                     /locus_tag="HHX31_RS29365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_169952251.1"
                     /transl_table=11
                     /translation="MAESSRIDGPELRADARRNRGRILVAAREVFAEHGIDAPMAAVAR
                     RAGVGVATLYRRFPTRDALVRAAFAQQMETCARALTEALSDPDPWRGFQRLIETVCKLQ
                     RQEQGFPAAFLAAFPQSMAAHAQARGRVERDLATLVRRAQAAGALRADFHPSDLGVILL
                     AHCGLVTALPHDGAASRRLVAYLLQSFRAEAAHGTLPPPSALSLRDLPLAPESSQRQRP
                     FRA"
     gene            14531..15493
                     /locus_tag="HHX31_RS29370"
     CDS             14531..15493
                     /NRPS_PKS="Domain: PKS_ER (23-317). E-value: 8.4e-43.
                     Score: 138.6. Matches aSDomain:
                     nrpspksdomains_HHX31_RS29370_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017569836.1"
                     /locus_tag="HHX31_RS29370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_169952253.1"
                     /sec_met_domain="ADH_N (E-value: 1.4e-08, bitscore: 27.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 9.5e-15, bitscore:
                     47.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDRMMRAVLFDRYGGPEVLYVGRVPRPEPAPGEVLVRVRAFSVN
                     GGELAARSGRIRLLTGRRFPQRVGLDFTGEVAALGPGAADVAVGDRVWGIVGRTGFGSA
                     AEYVTVRAERLGRVPDGLDLVDAAALPVATTAITALRDKAGLRPGERLLVRGAAGGVGN
                     AAVQLGHAYGAEVTALARAANLDFVRTLGAHHAIDHRAVPPSELGLFDVVLDTVGTDLP
                     AFRRLLKPGGRMVTIAFDLTRLAASLGYIAASAVHGRGRVRFFSGDPKRALFDDLAREV
                     AEGRLRPVVHTCFPLEETAAAHRALEAGGVRGKYVVKVS"
     aSDomain        14600..15481
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX31_RS29370_PKS_ER.1"
                     /evalue="8.40E-43"
                     /label="HHX31_RS29370_PKS_ER.1"
                     /locus_tag="HHX31_RS29370"
                     /protein_end="317"
                     /protein_start="23"
                     /score="138.6"
                     /tool="antismash"
                     /translation="RVPRPEPAPGEVLVRVRAFSVNGGELAARSGRIRLLTGRRFPQRV
                     GLDFTGEVAALGPGAADVAVGDRVWGIVGRTGFGSAAEYVTVRAERLGRVPDGLDLVDA
                     AALPVATTAITALRDKAGLRPGERLLVRGAAGGVGNAAVQLGHAYGAEVTALARAANLD
                     FVRTLGAHHAIDHRAVPPSELGLFDVVLDTVGTDLPAFRRLLKPGGRMVTIAFDLTRLA
                     ASLGYIAASAVHGRGRVRFFSGDPKRALFDDLAREVAEGRLRPVVHTCFPLEETAAAHR
                     ALEAGGVRGKYVV"
     CDS_motif       14900..14941
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX31_RS29370_0001"
                     /evalue="6.00E+01"
                     /label="PKSI-ER_m5"
                     /locus_tag="HHX31_RS29370"
                     /protein_end="137"
                     /protein_start="123"
                     /score="-3.1"
                     /tool="antismash"
                     /translation="LVDAAALPVATTAI"
     CDS_motif       14975..15034
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX31_RS29370_0002"
                     /evalue="4.00E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="HHX31_RS29370"
                     /protein_end="168"
                     /protein_start="148"
                     /score="19.4"
                     /tool="antismash"
                     /translation="GERLLVRGAAGGVGNAAVQL"
     gene            15792..16556
                     /locus_tag="HHX31_RS29375"
     CDS             15792..16556
                     /GO_function="GO:0009036 - type II site-specific
                     deoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855165.1"
                     /locus_tag="HHX31_RS29375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NgoMIV family type II restriction endonuclease"
                     /protein_id="WP_169952255.1"
                     /transl_table=11
                     /translation="MNAPFANDLLGWKTSKKGLVPNTADTDNAASKMIAARVLDVLGVP
                     DGIPTGVVDPKSGRPLERAVAHHLRLELPEHDHEREWNVHSAPVPISSFVQYSHLKEVD
                     RLVKANLELQITLGRDYLIKPDVAVSLPGRTISDLRFLHAAVSCKWTIRSDRVQNIRHE
                     NNQMIRHRRERLPHLVTVTAEPLPSRLAAIARGTGEVDAVYHIAYGALDQAVRELSTGR
                     HIQTDQLDAWEECIGLGRVRPFSDLAPTLARW"
     gene            complement(16606..17148)
                     /locus_tag="HHX31_RS29380"
     CDS             complement(16606..17148)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855163.1"
                     /locus_tag="HHX31_RS29380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="very short patch repair endonuclease"
                     /protein_id="WP_311932293.1"
                     /transl_table=11
                     /translation="MLTGMEVYASMSDEARKKAHALGLYPAPLNEGRSRNMRANRRSNT
                     KPEVALRSALHRLGYRYRKDLRVDLGDVKVRPDIVFTARKLAVFVDGCFWHVCPEHGRQ
                     PTTNEWYWAPKLRRNVARDRAADAALMAAGWRVVRLWEHVPLEVAIEAVVTALSPETEH
                     TDDDRACDRQDFSDSGT"
     gene            17227..18501
                     /locus_tag="HHX31_RS29385"
     CDS             17227..18501
                     /EC_number="2.1.1.37"
                     /GO_function="GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855162.1"
                     /locus_tag="HHX31_RS29385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA cytosine methyltransferase"
                     /protein_id="WP_169952257.1"
                     /transl_table=11
                     /translation="MALEVVEICAGAGGQALGLEKAGFAHALAVELDENASNTLRHNRP
                     KWAVRTGDVADTNVWKPSEFEGIALLAGGVPCPPFTIAGKQLGANDERDLFAWAVELTG
                     VVRPQALLLENVRGLSMPRFAGYRQHVLDRLRELNYVAEWRLLHASKYGVPQLRPRFVL
                     VALQEEFANYFHWPEPVGEPPTVGETLYDLMASDGWRGAEAWKAKANDIAPTVVGGSKK
                     HGGADLGPTRAKRAWAAMGVDALGVADAPPTVHDDPDFMPKLTTEMVARIQGWNDDEFP
                     WFFTGKKTSRYRQIGNAFPPPVAAAVGGAIAAALKKEAGTGERKRDRTQDPIYRVLRDS
                     GDYMTVNQIVREVKRILEPDEAREFKLEQHELERRIALLKRDFDIEMSSKSNAIAYKLG
                     QFRAFVGQDDHIRHEQFLKNRSKIS"
     misc_feature    17581..17583
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18635..19270)
                     /locus_tag="HHX31_RS36070"
     CDS             complement(18635..19270)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025637.5"
                     /locus_tag="HHX31_RS36070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HNH endonuclease"
                     /protein_id="WP_396712057.1"
                     /transl_table=11
                     /translation="MTDLRRALGDNNPNNAEHLNRRLRRLRRDGWRVPSNVDDRTLPVG
                     TYRLEAKGWHPGLGTRPRSEEVSAADRRRVFDRDNWRCVVCGVGSGEPYPEDPASRAVL
                     TVGHRIPRDLGGSVEIDNLQTECKRCNEPLRQELGLPETLAELLPQVRRFTTADLKTLL
                     SWLQAKQRIRTRVDTAYDRARRLSEGEQELLKQTLLKMIQGDPKSSSG"
     misc_feature    complement(18794..18796)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18857..18859)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18902..18904)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18929..18931)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19226..19240
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.74"
                     /tool="antismash"
ORIGIN
        1 ggaccttcgg cggcagggcc gcgaagctgg ccgatccggc cttgtcggcc cgcaggatgc
       61 cgaggccggt gccgggcagg ccgcgcaacg ccgcgccgcc gtcggtgtcc tccagccgat
      121 actcgcggta gccgaggaag gtgaagtggc cgtcggccag ccaccgcagc agttccatgc
      181 cgtcctcgac ctgcgcgggc tccagcggcg gcgggttgac cgccaggtcc tcggcggtct
      241 gcaccgcgag ggcgcgcatc ttggcgaagt cctcgaccgc gcagcgcacg tcgagcagca
      301 cccgctggag atcgccctcc agctccttga gcacggcgtg gtcggactgc ctgtcgatct
      361 cgatgtgcat ccaggactcg cggatgacct gcccggtcat gttctcctgg cccgcgccga
      421 gcagttcgcc ggtcatgtcg cggcacaccc gcatctgcgg gtggacgatc aggtgggtgc
      481 cgacctcgtg ccggtcgagc tcggtcgtca ccgagtcgac caggaacggc atgtcgtcgg
      541 tgacgatctg gaccacggtg cggcccgggt cccagccgtg ctcctcaagg gtgggggtgt
      601 agacgcggac cagcgcgcgt ccctgcggcc ggtgctgggc caggtggcgg tgggccatgg
      661 cggggccgta cacgttcacc gggtcgcggt cggccaggtc ctcggcgggc acgttgcggt
      721 agtaccgcct caggaaggcc agcgggtcct cgccctccac ctgcagcgct ccgggcgcgt
      781 gcgcgcacct ctcggccgcc agccggagaa gctcgtccaa agcttcatcc gattcctgcc
      841 gatccagcgc catttcgagc ggcatgttgc tactcactcc ctcgtgagga ttcaaagcca
      901 ggcccggagt tcccacagca ggggaaagaa gtgcagacgc gtccgtcccc tcaagtacgg
      961 tgccccggac gagcctcccg taccggattt cgtgccgatc tggcgctcca ccatctgcac
     1021 gtgcctcatc cgccagagcg cggtggtctc gtcgtgcgtg aggagatctt cggccaggtc
     1081 ccacagatcg tcgtacgacc cccggtcgcg ggccacggcc agcagggact ccatgatctc
     1141 ctcgtcggag accggcaggc cccgctggga gagggcgatg aggtaagcat cccacagagt
     1201 gggttcctcg agccgccgcc gcagcctggc gagttccgcg tcgctcgcgt ccctgagccg
     1261 gcccaggtac gacgggtcct tggcgccgga gaggaactcg agctcacgga actgaaccga
     1321 ctggaagccg ctcgcggggg cgagggccga ccggaactcc aggaagtcct gcggcgtcat
     1381 cgtcgccatc acctggacct ggtcgaccat gaccttctcc acggcgtgaa cgcggcggaa
     1441 caggtgcctg gcacgccaca gcgcgccctc gaccatcgcg tccctgatcc gctccagctc
     1501 gtgcagcagg agctggaacc acagctcgta gacctggtgg acggtgatga acagcagttc
     1561 gtcgctggcc cccgaccgcc gctcctgctg ggcgagcagc tcgggcaggc gcaggtagcc
     1621 gccgtaggac aggcgtccgc cctcttcgcc gaagctgcgg ggcgggggca gcacgtcccc
     1681 cgatccagct cggccgtacg gcgtcgcagg catgcgccac tcctccacga tgggcgcgtc
     1741 actcccgatc cccattgatc gcaagcccgg caccaccgca cccaaaacca cataccaccc
     1801 catagcggca caaacgtcaa cctcgtccgt gccttcccaa ccggggtggg cgccgggccc
     1861 atttaaccag cccctccccc gccgggagcc tcaactcgaa cgcatccccg tagccgctcc
     1921 cggcgaacgc ggcgcggtct ccggcacgcc ccgcacgatc acgactcgtc gcggagtgcg
     1981 gcgcgccgcc ggtacacgcc cgtgctgagg tacttcaggc ccgagtccac cagcagggtg
     2041 acgaccctgg cgtccggccc aaggcgtcgc ccgacctgga tcgcggcgag gacgttcgcg
     2101 ccggacgagg ttccggcgaa cagcccctcc tcccgggcca ggcgtctggc catctcctcg
     2161 gcgtccttgg tggtgatcgg gatgatctcg tccaccaggg cgggatccca catgggcggc
     2221 gggtaaccga tgccgatgcc ttcgatgcgg tgggcgccgg gccggcatcc ggacagcacg
     2281 gccgactcgg ccggttcgac cgccgtcacc cgaagctccg ggttgcggcg cttgagcggg
     2341 gcactcgctc cgcgcagcga ggccgctgta ccgatcgact ggacgaacgc gtcaacgcgc
     2401 ccacccgact gcgcccagat ttcctcgccc atggcgtggt agccggcgat gctgtcggtg
     2461 ttggtgagct ggtcggtcca gtaggtgccc cgccggcggc cgaactcctc ggcggtctcg
     2521 atcatgctga ggatcagcga cttcgtgatc agtcccccct cgctgggaat gagggtcagc
     2581 tccgcgccga acgccgccat ctggatgagc ttgtcctcac tgaaggcgtc cgagctgacg
     2641 atggacaggc ggtatccctt cgccgcgcag accagggcga gggaagcgcc ggtactgccg
     2701 cccgtgtact cgacgaccgt gtcgccgggt ctcaaccgcc cgtcgtcctc ggccctggcg
     2761 atcatcgcct gcgccatgcg gtccttcatg ctgcctgtgg ggttctggcc ctcgatcttg
     2821 acgaagatct ccgcgcaccc gggcggcacg acgccgcgca gccgcacgag cggagtgttt
     2881 ccgatcgttt ccagtacgcc gctgacgatg cccatgacgc cgccggtcct ttcgtcgatg
     2941 cccgctctca cgactccgat cgtcgaacct gtgcgccgac cccgacagtt caacttttga
     3001 accaccaggc ccgggccgcc gtgcctacca tgcacctgtg agcggatacg gccagttctg
     3061 cgcggtggcg cgcgctctgg aacttctggg cgaacgctgg acgctgctga tcgtgcggga
     3121 gttgctgctc ggcgcgtcga ccttcaccga catccgccgc ggactgcccc gcatcccgcg
     3181 ggcgacgctg gccgcgcggc tacgcgccct gcgcgccgcg ggcgtcctcg acggctaccg
     3241 gctcaccgag gcgggcgccg ccctggctcc ggtggtaagg gaactcgcac gatgggcggt
     3301 cgccaccgac agcgtcgctc tcaccgagaa cgacctcgac accgccgcgc tgacctggga
     3361 catgcgacgc cgtgtgaacg ccaccgcgtt gccggagcgc accgtcgtgc tcgccgtcga
     3421 gttcaccgac cgcccgccgg ccgaccgcag atactggctg cacctgtcct cggcgagcgt
     3481 cgatctgtgc cggcaggaca tcggagcacc cgtcgacgtc tggctctcca cgccgatcgc
     3541 ggcggcgacc cggtggtggc tcggcgacct ctcctgggcg caactgctgc ggcagccggg
     3601 cgtacgggtc gacggcgacc gaacgctgca gcgccagatg caccgctggt tcgaacgcta
     3661 tgtgttcact ccggaaaccc ttggcctgcg gcaggcgtcc ccttccggct gaacgacgct
     3721 cggccgccgg ggagcggtgg cggccaccgg cttcggggga caggtcctgc gagtaggaac
     3781 gaagtgacga ctctgtaacg aaccagtgcg gatcacccgg cgtctcaaga ggggaccacc
     3841 acctcgggag cacgaccatg attgacagac ggagtttcct tcgggcctcg gcgctggccg
     3901 gggcgggggc gttcgcgggc acgggcttca cctcggcggg tccccgtccc gccgactggt
     3961 ccgcgctcgg ccgggggctg gacggcacgc tgatccggcc cggcgacgcg tcgtacgaca
     4021 acgcgcgccg cgtgttcaac tcggccttcg actccgtacg gccgaccggg gtggcctact
     4081 gcaggacggc cgcggacgtg tcggagtgcc tggcgttcgc ccggcgccat ggggtgccgg
     4141 tgacctcccg gtcgggcggc cacagttacg cgggctggtc caccggcagc ggcctggtga
     4201 tcgacgtgtc gccgatgaac ggcgtgtcgc actcgggcgg ccacgccacg atcggcgccg
     4261 gggcgcggct ggtcgacgtc tacgccaagc tggccgcgcg tggcgtaagc atcccggcgg
     4321 gctcctgccc gaccgtcggg gtggccgggc tcaccctggg cggcggcctc ggcgtggtct
     4381 cgcgccggta cggcctgacc tgtgacgtgc tggagtcatt gaagatcgtc acggcggacg
     4441 ggaaggtgct gacctgctcg ccgaactcgc acccggacct cttctgggcc tcgcgcggcg
     4501 gcggtggcgg caacttcggc gtggcgacgt cgttcacgtt ccggacgcat ccgacgcggc
     4561 cggtgaccct gttcttcctg cactggctgt ggtcgaaggc ctcggccgtg ttaaaggcct
     4621 ggcaggcgtg ggcgcccgcc gcgccggacg cgatgtggtc caactgccac ctcggccacg
     4681 acccgtcgct cgacgtgatg gtcggcgggc tgtatctcgg cggcaaggcg gcctgcgaga
     4741 gcctgctgca caagctcgtc gaccgcgtcg gatcagcccc ctcgaaccgg tatgtcgcgg
     4801 tctcggcgta cgaccacgcc atgatggtgg aggcgggctg cgcgtcgatg tccgtggccc
     4861 agtgccaccg tcccggcacc ttgcccgggc agaacccgag cggcaggctc gtgcgcgact
     4921 cgttctcggc caagtcgcac ttcgcctaca cgccgttgtc gtccgccggg atcaaggcgc
     4981 tgctggccca ggtcgccgcg ccgggacggc acatcgtgat gctcgacgcg atgggcggcg
     5041 ccatcggccg ggtccgcccc gacgccacgg ccttcccgca ccgcaaggcg ctgttcagcg
     5101 tgcagtactt ctcacacttc gccggcgccg cctcctgggc ccgcgccgcc cacgccgcca
     5161 tgcggcccca cttcggcgac cacgcgtacg tgaactacgt cgaccccgag ctcaagaact
     5221 ggcggcagca gtactacggc gcgaacgccg cccggctcgc caaggtcaag gcggcgtacg
     5281 acccgggccg gttgttccgc ctcccccagg gcgtctaggc agccgcggcg cgggacgtcg
     5341 gacgagcctt gcctccacct atcgaatttc gatagattac tatcgttctt cgatggagga
     5401 gaggcaatga gaagactgac attgctcgca ttgcgggccg tgctcgtggc gctgctcgcg
     5461 ggctcggtgt tcgtgcagac ggtgatggtg ccgttgcttg cctccgacct ggagggactc
     5521 gacccggagt acgcgtacct gcgcgccccg atcctcgcgc tcacggtcct gggcgtcgcg
     5581 gcggtcgagg tcgtcctggt ctgcgtctgg cggctggtca cgatggtgtg gcgcgacacg
     5641 gtgttctccc acgccgcctt ccgctacgtg gacgtcgtca tcggcgcgtt cgtggcggcc
     5701 gccctcctcg ccttcgcgct cgggttcctc ctggcccccg gtgaggccgt tcccccgggc
     5761 gtcgtcctcc tggtgggcgg ggtcggcgtg gcggctctcg gggtcgcgct cgtcgtgctc
     5821 gtgcttcggc tgctgctcgc ccaggccgtc gcccgcgacg gcgaggcggc gcggatgcag
     5881 gccgagctcg acgaggtgat ctgatgccga tcgtcgtcga catcgacgtg atgctggcca
     5941 agcggaagat gtccgtgggc gagctcgcgg accgcgtcgg gatcacgccc gccaatctcg
     6001 ccgtgctcaa gaacggccgc gccaaggccg tgcgcttctc gaccctcgcc gcgctatgcg
     6061 aggtgctcga atgccagccg ggagacctgt tgcgctggga ggccgaggac gaggcgtgac
     6121 ctcgaccggt tgccgagcga ggcggattgg cgtccggtcg ccgcgaggcc tcggcgcgcc
     6181 atgctgtcgg ccaccctggc cgcgcgccgg cgcgggcggg ctcgactcac ggatcggggg
     6241 ccccaggaaa tgtaaccgac ggcccgcgaa atgtaactgc ccttggttac atttcccgca
     6301 tgcctgccga cgtgagccac ctcatcgacg agcttcgggc agccggcggc gactcgacgg
     6361 ccatagaggt caaatcggcc gccggaggac ttcccgactc gctgaccccc actctgagtg
     6421 cgctcgcgaa tctgcccggc ggcgggacaa taattctcgg gctggacgaa cggttcgggt
     6481 tccgaccggt tccgctgccg aacgcgcagt cgctgaaaca gggcctcgcg gcgaaggcgc
     6541 gctcgttcac cccgccagtc cgcctcactt tggacgacgg catcgcgtac ggcgccccgg
     6601 tcatagtggc gagggtgcac gagtgcgaca agtccgccaa accatgccgg gtcacagcca
     6661 caggcgcctc ctatctccga ggatatgacg gcgatttccg gctctcggat atcgaggaac
     6721 aagccttcat cgcggcacga cgggcaccta tgttcgatcg gaccctggtc gagggagcca
     6781 cctcggcgga cctcgacccc gaactggtga aggcgttcct cgaggcggtc cgcgagcgcg
     6841 atcagcaggg gttggggcgc ttcgtccggg atgacgaact gctttgccgt gccggagtga
     6901 ccgccgtcga cggcaggccc acagtcgccg ggctactggc tctgggcacg catccacagc
     6961 agtggttccc ccgatacgcc atccagatat ccgccgatcc actgcctgga gatccacccg
     7021 gttcccgggc ccgcaaccag gccgtcctga gcggacccat tccccgaatg ctggacgcgg
     7081 ccatggagtg ggccagacga accttcgata cggccatcgt ggcggggccc gacggcaccg
     7141 tccgggatct gcccgtctat ccgcttatcg cctttcgtga actggtcgcc aacgcgctga
     7201 tacaccgcga tctcgatcac tggtcagcgg gaatggccgt ggaaatcagg cttcgccggg
     7261 atcgtctggt aatcgcgaac cccggagggc tctatggcat aacggtcgat cgcctgggca
     7321 aagaagcggt cacatctgcg cgcaacgcgc ggctcgtcgc catttgccag aatgtgcgtt
     7381 cccccttcag cggcggccgg gtcatcgagg ccctcgccag cggcattccc actgtgggcg
     7441 cggcactcga cgaggcgcgt ctacctcccg ctcattacat cgacgcgggc atccgctttg
     7501 tcgtgatcct gcaccggccc atcgtcgcga ctccggcagc cgacccgctg aacgctaccg
     7561 agtcacgcgt ccttgacacc cttgcgcaag ggaccctcac cgtcgcgcaa ctggttgaga
     7621 tgctcaatct cacggcaccg aacatccgga aggctctccg tggcctacgt gagcaaggct
     7681 atgtgcgaca gcatggcggc cgaggaaagt tcacgtacta cgagcgcgcc tgatgccacg
     7741 agcggaacgc tcatagacgt atcggtgtag acgagggtcg ggccaggtga ccggcaccga
     7801 gtcaccggcc ttctcgtagc tgattgtgat agttagatta ctgtctgcaa tcaactcggg
     7861 ggtagtccat gaacgtgtct cgatctcgta cgtacctcgc ctgtggtctc ggcgccgccg
     7921 gggtggccgt gctgggcctg gccctgtcgg tcgtcccatc ggtggcccag ggcgcgtcgg
     7981 gcggcgagcg caccaggccg gtcgtcaacc cctcaccgaa gcagcccggc ggccacaccg
     8041 tgctgacgtg cgcgatgagc acgggcagcg ccgagccgat cacggccgag cccgcggtgg
     8101 gcaaggaggc ccgtacggtg tcggcccgtg gcgtcctgac cctcaccggc tgcgcgtcgc
     8161 ccgacggcag cttccccaac atccgctcgg ggaaggtcac cctccagggc agcgcccagg
     8221 cctcctgcac cggcgtccag aacgtcaccg gcacgggcac cgtcacctgg aaggacgccc
     8281 agggccagac gttgggcacc tccacgatcc ggcccaacat ggacgggatc ccctcgtaca
     8341 accccggcga catgatgctg gtcggcgagg tcgtcgaagg gaagctgaag ggcaagcgga
     8401 tcgccggaaa ggcggttccc acgtccgaca tcggccagtg ctccgccaag ggcgtgagca
     8461 gcgtccaggg caccggctcg gtcgcgttca tcgccgtcgg cacaccgaag tagcggcgca
     8521 tccgagtggc gcagtcaggt gggaccaggt cgagggaggt ggcgcgtgcc gtcggatgag
     8581 cccgtgctcc gggtgcggga cgtgcggaag ggctaccggg gcggcccggt cctgcgtggc
     8641 gtcgatctcg acctgccgcc cggccaggtg gcggggatcg tcggggagaa cggcgcgggc
     8701 aagacgacgt tgctgcgcgt cctcgccggc gacctgcggc cggacggcgg atcggtgcgc
     8761 catcgcgggc gcgtcggcca ctgcccgcag gagacggtgc tgcacgacgc gttcaccgtc
     8821 gagcagcacc tgcggttctt ccgggtcgcc tacggcatgg agagcctgac cagggccgag
     8881 gagttgatgg aggcgctgcg gttctccggc tcccggcggg ccaggccggc cacgctgagc
     8941 ggcggcacgc ggcagaagct caacctcgtc ctggccctga tgcacgaccc cgacgtgctc
     9001 ctgctcgacg agccctacca gggcttcgac tgggagacgt acgtgcggtt ctgggacctg
     9061 gccgacgaac tgcgggcgcg tggccgctcg gtgctggtgg tctcccacct cgcgtacgac
     9121 gccgcgcgcc tcgacacgct ccatcggctg gagggcggcg tgctgcgggc cgccgaaagg
     9181 accggcgcct gatgggacgt cactgggagt gttacgccac cgccgtgcgc atgacgttcg
     9241 tggagcatct gcgcaaccgg ctggccctcg tgatcatcgt ggtcttcatc ccggtgtggg
     9301 cggtcctcat ctacgccctc tccctggaga tcgcgcttcc gttccacgtc cgcgccgcgg
     9361 agcgggtcgt cgtcctgccg gccaacgtgc tcaaccagct cgcgggggcg ctgcagatac
     9421 tcgcgctgat caccgggttc atgatgttcg tgaccacgtt gcactcggcg tccttcgatc
     9481 gccggctggt gcggtcgggc tttccccggc tgtgcctggt cgcggcgaag ctcaccgccc
     9541 tggtggtggt cgcgctctgc gtcgcggcgt acgcgaccgg cctgatctgc ctcacccacc
     9601 ggcccgcgca gcccctcctg ctcgccgccg ccctcttcgg cggggcgctg atctatggcg
     9661 gcatcggcgt cgtgctggcc gccgtgctga ccagcgacct cgccggtctg gtcctcgtca
     9721 cggtgatctg ctcggtcgac ctggccctgc agagcccgct cgccaccccg gccgcggccg
     9781 gcaccgtcgt gcgttacctg cccgactacg ggccgatgca gggggccgtc gcggcggtgg
     9841 ccctggacac ggtgccctgg agcgccgtcg ccccggccgt gtgctgggca ctgggcaccc
     9901 tggccctcgg cgtctccgct ttcgccgccc gcacccgcgt ccaccggccg gtgggcgggc
     9961 ccgcggccct ttccgcctga accccccgtc aggagcttcc atgacatccg agaccgtcgc
    10021 ccgcgtcttc cccgccctgg agtccgacct ggagcgggta cgcgagatcg tcggcctggc
    10081 cgacgtgccg agccgcgccg agctgacggc gctgaccagg cagcccgccg ggcaccggca
    10141 gctgatccgg cccaccctga ccctgctgtc ctactacctg ctcgccggtc ccgagcgggc
    10201 cgcccacgtc cgcgccgtca aggccgcggc ggccgtcgaa ctgctgcaca tggcgtcgct
    10261 gcggcacgac gacgtgatcg acggcgcgcg gcagcgaagg ggcgggccca gcgtcaacag
    10321 cgtgtggggc gcccgcctgg cggtcctggc cggtgacctg ctgttcatca gcggcagcag
    10381 gatcgtcgcc gaactgggcg agcgcgaggc gctggtgtcc gcggaggccg tccagctcat
    10441 ctgctcgggc atgatcgccg agaccgccga ccgtttcctg ctctcccgca ccgaagaggc
    10501 ctatctggag gtgaccggcg cgaagacggc cgagctgctg tccctggcct gccggctggg
    10561 cgccatgcag gccggccggg acggggaggc ggaggaggcg gtggcgcggt tcggctggca
    10621 cctcggcatg gcctaccagg tgcgcgacga cgtcctcgac ctgaccgcca cggccgggga
    10681 gctcgggaaa cccgccaact ccgacatggc agaaggcgtc tacacactgc ctgtgatcag
    10741 ggccctggcc cgcgagcccg cgctcgcccg gctgctgcgc cgcggcctga ccacggccga
    10801 caccgagcag gcgcggcggc tggtcctgtc ctgcggagcc gtggaggaag ccgggaaggt
    10861 cgccggtgag cacgcggagg cggctgtcgc gcggctcagg gacgtcggcg atccgaggtc
    10921 gcgcgaggcg ctggccgcct acgtgcgctc ggtcatggga tcggtaacgg gctcgggcat
    10981 ggggccggtc gggcaggccg gccgtgaccc ggtgaccgtg cccgtctccg cctcggtccc
    11041 cttgcggggc gacgacggcc tggtccgggc ggtgcaggag cggctggacg cctggttgct
    11101 cgactccggg ctggccgcga cgcgagagga gagccgtcac ccgcgctgga gcggcatggc
    11161 cgcggccacc gcgctgatgt ggccgggcgc cgacgccgag cagctcgaaa ccctcgccag
    11221 gtggatgctc gtgtgcatcg tgctcgacga cctcttcgac gagccgggtc tcgcggaccc
    11281 cgcggaggcc gcccggctgc gtcaccggct cgccctgctc atcggcgggc tcgacgacgc
    11341 cccgccggcc ggcggcgcgt tcgccacggc cctggcccag gcgtgggagc ggctccgcct
    11401 gacccagcca ccctcgtggc ggacgcgggc catcggccac ctgctcgact ggctggacgc
    11461 ggccgagcgc gaggcgtgcc accggctcag cggctatgtc cccagcctgc gcgaccagtt
    11521 cccgctgcgt ctggggagcg ccgggatccc cgtattcctg gacgccttcg agatcagctg
    11581 tggcagggag ttcgcgccgt ccgtacgcga ccatccgctc ctgcggcggt tgctggacct
    11641 cggctcggcc accgtgctcg cggagaacga cctgcggacc ctcgaccagg acgaggccac
    11701 cggcaccccc tacaacctcg tcacggtgct ccgccacgag accggctgca ccaggcagga
    11761 ggctatcgac gaggtgaccc gccaggtcga ggacggctac gcccaggtgg acgccatcct
    11821 ctcctccgcg cccgccatcc tgcggcccgc ctcgggcgac gcggactccg taccggtcgt
    11881 cgcgatcctg cggatcgtcc gggaccggct cgcgggctgg cgcgcgatcc acgacgtcga
    11941 ccgctacagc tcgtcgtccg cgggcggcgg gacgcacctg gcccggctgc gccgggaact
    12001 cctgctggag tacgccgaga gcggcgcggc acgctgacat tcccggccgg gtcctcagcc
    12061 ggatcggtcc gtggcgaggc ggtcgagcca ttcgccgagc acgtggcgtt caccgtcggt
    12121 gagagccgtg gcgtcgggca gtgcggcgcg cagtgccatc gccgccgcgg cgggtcctgg
    12181 ggtctcgacc acgggtgcgt cggtcgtgat ggcggccatc gccgcctcac gggccacctc
    12241 ggacaggcgc gggtcacgcc gttcctcggg catggcgagc agcgtgaaga ccgtgccgca
    12301 gccggctgcg tgcacgaggt cggccgcgag gcgctcgccg acccgcaacc ggccggcggc
    12361 ggcgatggcg cggatgcgct cccccagcat gcggaaggcg gccacggcgg cgggcgactg
    12421 ccgtcccggc gtgggatcgc cgtacatgag cgagaacaag gcggggttgg ccagcccgaa
    12481 cccgacgtgc aggtcccatc cggcgcgcag cccttcgacc gggtcgcctg cgggcgggct
    12541 cgccagcttg tcccgcaggt aggagccgaa gccatactcg gcgaccgcgt cgagcaggcc
    12601 gtccttgtcg ccgaacaggc ggtagatcgt cggcgcctgg gtccccgccg cggcggccac
    12661 cgccctggtc gagagggcat cgcgcccgcc gctcgcgagc aaccgcgccg cgaccgacac
    12721 gatgtgcgcc cgcgtcctgt cacggccgct cgccgtctcg ttctcaggat cgctcacgct
    12781 tccaacgata tcagtgagtt gctatcggcg aatttccggt gttagcgttc agcagatacc
    12841 actgataaca cctggagaag cgcatgatga tcatcaccgg ggcgaccggc cagctcgggc
    12901 gcggcgtcgt cgaccgcctg ctcgcacgcg tccccgccga ccggatcggc gtcagcgtcc
    12961 gtgacgtgcc gcgagccggc gacctcgccc ggcgcggcgt ccgcgtacgg cgtggcgact
    13021 tcgccgaccc cgcgagcctc gcgtacgcgt tcgagggcgc ctcgcgggtg ctggtcgtct
    13081 ccggcccggc cgacgccggc ccgcaccgta cggcgatcga ggcggccaag gcggcgggcg
    13141 cagggcggat cctctacacc agccacatgg gcgcgaaccc ggcctccccc ttcctcccga
    13201 tgccgtccca cgccgagacc gagcatgacc tgcgggagat cggggtgccg ttcaccgcgc
    13261 tgcgcaacgg cttctacgcg accaccgcgc tcaacttcgt gagccaggcg ctcgagaccg
    13321 gcaggctcgt cgcacccgag gacggcccgg tctcgtggac cgcccacgcc gacctcgccg
    13381 aggcggccgc catcgcgctg accgaggatg gccggctcga cggggtcacg ccgccgctga
    13441 ccggccccga gtcgctcgac ctcgcggacg tcgccgcgat cgcctccgag ctgaccggtc
    13501 gcgagatcac ccgcgtcacc gtcccggacg gcgagtgggt cgcgggcatg gtgtcgcgcg
    13561 gcatgcccga gcagcaggcc aggttcctgc tgggcatgtt cgaggccagc cgtcgaggag
    13621 agttcgccga ggccggcccg gcgctcggcg acctgctcgg ccgtaagccg gccgcgctcc
    13681 gcgacgtgct cgcgaaccga taaggctgcc ctccggacct tcaggacagc acgttaacgg
    13741 cggtccgtgt caggccctga agggccgctg ccgctgggag ctttcggggg cgagcgggag
    13801 atcgcgcagc gacagggcgc tcggcggagg cagggtcccg tgagccgcct cggcgcggaa
    13861 cgactggagc aggtaggcca ccaggcgccg ggacgcggca ccgtcatgcg gcagcgcggt
    13921 gaccagacca cagtgggcca acaggatcac gccgagatcg gaagggtgga aatcggcgcg
    13981 aagcgcgccc gccgcctggg ctctgcggac cagggtggcg aggtcacgct cgacccgtcc
    14041 tctggcctgc gcgtgtgcgg ccatgctctg cgggaacgcc gcgaggaacg cggcggggaa
    14101 gccctgctcc tgccgctgaa gcttgcagac cgtctcgatc agccgctgga agccccgcca
    14161 ggggtcgggg tcggaaagcg cctcggtgag cgcccgggcg caggtctcca tctgctgcgc
    14221 gaacgcggcc cgcaccaggg cgtccctggt cgggaaacgc cggtaaagcg tcgccacgcc
    14281 gaccccggcc cgccgggcca cggccgccat gggcgcgtcg atcccgtgct cggcgaagac
    14341 ctcgcgggcg gcgacgagga tgcgtccccg gttgcgccgg gcgtcggccc gcaactccgg
    14401 gccgtcgatc cgagaggatt ccgccaccac tgtctcccac ttccggtcga aacggacggt
    14461 gccgtccggt tatgagccta cgttcgaagc ctgatccccc acgcggccac ggttggcgaa
    14521 ggtgagaacg atggacgacc gcatgatgag agccgtgctc ttcgaccgtt acggcggccc
    14581 ggaggtgctg tacgtaggcc gggtgccccg ccccgaaccg gcgcccggcg aggtgctcgt
    14641 gcgggtgcgc gcgttcagcg tcaacggcgg cgaactggcg gcccgttccg gcaggatccg
    14701 tctcctcacc ggacggaggt tcccgcaacg cgtcgggttg gacttcaccg gcgaggtcgc
    14761 cgcgctcggc cccggggcgg ccgacgtcgc ggtcggcgac cgggtgtggg gcatcgtggg
    14821 ccgcaccgga ttcggcagcg cggccgagta tgtgacagtc cgggccgagc ggctcggccg
    14881 ggtcccggac ggactcgatc tggtggacgc cgccgcgctg ccggtggcga cgacggccat
    14941 cacggcgctg cgcgacaagg ccggactgcg ccccggcgaa cgactgctcg tgcgcggcgc
    15001 cgcgggaggc gtaggcaacg ccgccgtcca actcggacac gcgtacggcg ccgaagtcac
    15061 ggccctggcc cgcgccgcca acctcgactt cgtccgtacg ctcggcgccc accacgccat
    15121 cgaccaccgg gccgtcccgc cgagtgaact gggccttttc gacgtggtcc tcgacaccgt
    15181 gggcaccgac ctgccggcct tccggcgcct gctgaagccc ggcgggcgca tggtcaccat
    15241 cgccttcgac ctgacacggc tcgccgcctc actcggctac atcgccgcca gcgccgtaca
    15301 cggacgcggc cgggtgcgct tcttcagcgg ggacccgaaa cgagcgctct tcgacgacct
    15361 cgcccgtgag gtggcggaag ggagactgcg ccctgtggtg cacacctgct tcccgctgga
    15421 ggagacagcg gcggcccacc gcgcgctgga ggcgggcgga gtgcgcggca agtacgtcgt
    15481 caaggtcagc tgagggcgat ccaccgactc acctctctgc ggagccgacc ctgcggaggc
    15541 gggagcgtac ggcgcggcgg acgaccgggc ccatgtcgtc gaggacggcg accaggctgt
    15601 cgaacgcccg ctccgcgccg tccttgtcga ccccctcgta cagttcgagg ccgacgaagg
    15661 cggcaacgtc gacgtaggcg gcccggcagg cgctcggcct ggcgcgaagc cgaatgctgt
    15721 gtcggctcca gctgcgacag tcagcgacta gagtgggctc cccgctacga tctcgcccag
    15781 aggttgccca ggtgaacgcc cccttcgcta atgaccttct cggctggaag accagcaaga
    15841 agggtcttgt accgaacact gccgataccg acaacgcagc ctcgaagatg attgcggcca
    15901 gggtcctcga tgtgcttggc gtcccggacg ggatccctac cggagtggtg gaccccaaga
    15961 gcggccgccc tctggaacgt gctgtcgcac atcacctacg gctggaactg cccgagcacg
    16021 atcacgaacg agagtggaac gtgcatagtg cacccgttcc gataagcagc tttgtccagt
    16081 acagccacct aaaagaggtg gaccgcctcg tgaaggcgaa cctggagctg caaattacgt
    16141 tgggccgcga ctatctgatc aaacccgacg tcgcggtcag cctcccaggc cgaaccatct
    16201 cagacctgcg gttcctccac gcagcagtgt cctgtaagtg gaccatccgc tccgatcggg
    16261 tacagaacat caggcatgag aacaaccaga tgatccgtca tcgacgggag cgcctccccc
    16321 acctggtcac ggtgactgcc gagcccctac ccagtcggct ggccgccatt gcccgcggaa
    16381 cgggcgaagt cgacgccgtc tatcacatcg cctacggggc cttggatcag gcagtgcggg
    16441 agttgtctac cgggcgccac atccagactg accagctaga cgcatgggaa gagtgcatcg
    16501 gccttggccg ggtacgccca ttcagcgatc tcgcaccgac gctcgctcga tggtaggacc
    16561 gcgccgatcc cactgggagc gctttccacc aagccacaga actgatcacg ttccggagtc
    16621 gctaaaatcc tgtcggtcac atgctctatc gtcgtccgta tgttcggtct cggggctcaa
    16681 agcagtaacc accgcctcta tggcaacctc cagaggcaca tgttcccaga gacggacgac
    16741 gcgccagccg gccgccatca gcgcggcgtc ggccgcgcga tcccgcgcaa cgtttcggcg
    16801 aagcttgggt gcccagtacc actcgttcgt ggtgggctgg cgaccatgct cagggcagac
    16861 atgccagaag cacccatcga cgaagacagc aagcttacga gcagtgaaga cgatgtcagg
    16921 acgcactttc acgtcgccaa gatcgacgcg aaggtccttg cggtaccggt agccaagtcg
    16981 atgcagcgca ctacggagag ctacttcagg cttagtgtta cttcggcgat tagctcgcat
    17041 gttacgagaa cggccttcgt tgagcggcgc cggatacaaa cccagcgcgt gagccttctt
    17101 acgcgcctca tcactcatgc ttgcatacac ctccataccg gtgagcacca acagtcctat
    17161 cctcaactgt gaagatacag ctagtacacg tccgcgttgt tcctgaaccc ctagaggaga
    17221 acctccgtgg ctcttgaggt cgttgagatt tgcgctggtg ctggtggcca ggcgctcggc
    17281 ttggagaagg ctgggttcgc gcacgcgcta gccgttgaac tagatgagaa cgcctccaac
    17341 acgctccggc acaaccgtcc caaatgggcg gtgagaacgg gcgatgttgc cgacacaaac
    17401 gtatggaagc cgtctgaatt cgaaggaatc gcgctcctcg ctggcggcgt tccctgcccg
    17461 cctttcacca ttgcgggcaa gcaactgggg gcgaacgacg aacgtgacct cttcgcttgg
    17521 gcagtggagc taacaggagt agttagaccg caagcgctac tgctagagaa tgtacgtggg
    17581 ttaagcatgc cacgctttgc aggctatcgg cagcacgtcc tggatcgcct ccgcgaactc
    17641 aactatgtag ccgaatggcg acttctccat gcgtccaaat acggcgtacc tcaactgcgc
    17701 ccgcgatttg ttctagtcgc cctacaggag gaatttgcca attacttcca ctggccagag
    17761 ccagtcggtg agcctccgac ggtcggcgaa actctttacg atctcatggc atctgatggt
    17821 tggcgaggtg ctgaagcttg gaaggcgaaa gctaacgaca tcgctccgac ggtagtcggc
    17881 ggctccaaga agcatggagg tgccgacctt gggcccacta gggctaagcg cgcttgggct
    17941 gcgatgggcg tcgacgccct gggcgtagct gacgccccac cgactgtgca cgacgacccg
    18001 gacttcatgc cgaagctgac aaccgagatg gttgcccgaa tccaaggctg gaacgatgat
    18061 gagtttccgt ggttcttcac tgggaaaaag acctcccgct atcggcaaat aggtaacgcc
    18121 ttcccccctc ccgtcgctgc tgccgttggc ggagcgatag ctgcggcctt gaagaaagag
    18181 gcggggaccg gcgaacgcaa gcgcgatagg acgcaagacc cgatctaccg ggtactgcgc
    18241 gatagtggcg actacatgac tgttaaccag atcgtgcgcg aggtcaaacg aatcctggag
    18301 cccgacgagg cgagggagtt caagctcgag caacatgagt tggaacgcag gatcgccctt
    18361 ctcaaacggg atttcgatat cgagatgagc agcaagtcca atgctatcgc ctacaagctg
    18421 ggtcaattcc gagccttcgt cggccaagac gaccacatcc ggcatgagca gttcctaaag
    18481 aaccgatcaa agatcagcta gcatagctgt aattttgatg tcgccaggcc agccacaaag
    18541 gggcgtcttg ttacaggcag ccatctgtgc cgggccctca aaggatagca actcagcgag
    18601 agcccggcac atccctgtac gacaactgcc acatctaccc actactgctt ttaggatcac
    18661 cctggatcat cttaaggaga gtctgcttca atagctcctg ctccccctcc gatagacgac
    18721 gcgctctgtc atatgcagta tccacccggg tccgtatgcg ctgcttggcc tgcaaccacg
    18781 acaacagtgt ctttaagtcg gccgtagtga atcgccgcac ctgcgggagt agttccgcca
    18841 gcgtttcagg caggcctaat tcctgccgta gcggctcatt gcaacgttta cattctgtct
    18901 gtaagttatc gatctcgaca gaccctccta agtctcgggg aattcgatga cctaccgtga
    18961 gaactgccct cgaggctggg tcttccgggt agggctcgcc gctacctacc ccgcagacga
    19021 cgcagcgcca attatccctg tcaaagacgc ggcgccgatc tgctgctgac acctcctcac
    19081 ttctggggcg cgttccgaga cctggatgcc accccttagc ctccaggcga taagtaccga
    19141 cagggagagt tcgatcatcg acgtttgaag ggacacgcca accatcccga cgaagccgcc
    19201 tgaggcgccg attcaaatgt tctgcattgt tcggattatt gtcgcccagc gctcgccgaa
    19261 ggtccgtcat tgtgaacgtg tccccctcgt tgacgttgaa cgtcaaccat gcagcgagct
    19321 tccgctcatc gccgtacggc cgacgcgtcc caggcgcgta gcgcagacgc caccaaagtt
    19381 cgccatttgg tgcataggcc ccagcagggt agtcccggct gtcagcacca ttctctgcag
    19441 tcacctagca atgtctagta tgtccgtacg atcagcacaa atctgcacgt gacgtgcccg
    19501 acactcatcg cccttctgcc atacgatgat gctagtcacg gtgcacatgg ctatttacag
    19561 tacgagttga gtgagtagtg tcaccactga cggggtcacg ggggaatgtc cagtcaacgg
    19621 tgtaactcgc ggctgatttc ttctatcgag aggccgggga tagccggcct tcgaaggtga
    19681 tggcgaaggc gttgagggcg gctttccagc gggtgaccca gcgtttgc
//
