LOCUS       NZ_JABBWV010000014     21158 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H11081 NODE_14, whole genome shotgun sequence.
ACCESSION   NZ_JABBWV010000014
VERSION     NZ_JABBWV010000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H11081
  ORGANISM  Microbispora sp. H11081
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 179646)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 179646)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Anotibioctics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012999535.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:41:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,738
            CDSs (total)                      :: 6,662
            Genes (coding)                    :: 6,604
            CDSs (with protein)               :: 6,604
            Genes (RNA)                       :: 76
            rRNAs                             :: 5, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            partial rRNAs                     :: 1, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 58
            CDSs (without protein)            :: 58
            Pseudo Genes (ambiguous residues) :: 0 of 58
            Pseudo Genes (frameshifted)       :: 7 of 58
            Pseudo Genes (incomplete)         :: 54 of 58
            Pseudo Genes (internal stop)      :: 2 of 58
            Pseudo Genes (multiple problems)  :: 5 of 58
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:04:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 131320
            Orig. end                         :: 152478
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBWV010000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21158
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21158
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21158
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11158](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11158
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(292..1107)
                     /locus_tag="HHX31_RS35350"
     CDS             complement(292..1107)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019144.5"
                     /locus_tag="HHX31_RS35350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Sua5/YciO/YrdC/YwlC family protein"
                     /protein_id="WP_169951657.1"
                     /transl_table=11
                     /translation="MVISASPGARRSEHGLCSACVRELFDRAGRRYMYPLVCCDDCRPP
                     GGPAHSAVLCADCGQECRGPHPRRSVSAATGCTACGPGLRWNGVTGQDALAAAVAAIGA
                     GGVAGLHDLFADQVVCDARSEHALARMDGASGRVRVLVRNVSMAREVANLLPPDIRALV
                     ERTEPATLVRLREPVLPRAVRRATPDVDLFLPRTPLQYLLAARVDGPLVVWDRPAERAD
                     EWPCDGTLTVSGLARAERQSRTAGLPARLALGGPSPVILTKGPSPVSTP"
     misc_feature    1149..1164
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(1170..1811)
                     /locus_tag="HHX31_RS27660"
     CDS             complement(1170..1811)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629055.1"
                     /locus_tag="HHX31_RS27660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_169951658.1"
                     /transl_table=11
                     /translation="MNAIVVFGAGGRAGRAVVREARERGHRVTAVVRDPAAYVSGEGSP
                     AVDDVVAGDVTDTDAVARIAAGHRAAVNAAADLTAPPMEFFPAAARALLGGLERAGVPR
                     LIAVGLATGLRTAEGTLLMDTPGYPQEYREFYLGHEAGDAVLREAVTPVDWLVISPSGD
                     FDHDGVRTGGYRVAPGDAGSRISYADLAVAVLDEVERPRHSRVHIGVERI"
     misc_feature    complement(1804..1815)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     misc_feature    1866..1883
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    1880..1895
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     gene            1913..2266
                     /locus_tag="HHX31_RS27665"
     CDS             1913..2266
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892114.1"
                     /locus_tag="HHX31_RS27665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_169951660.1"
                     /transl_table=11
                     /translation="MTEPLDPDMFDPLCPSGLMPIRLGDKWSGMIIRCLEHGPRRFSEL
                     RVPLRGISAKVLTQSLRALERDGFVLRTAHPGAVQRVEYALTPLGRSLIEPLNTMCAWA
                     EDHWEELLDAREA"
     gene            complement(2312..3127)
                     /locus_tag="HHX31_RS27670"
     CDS             complement(2312..3127)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="HHX31_RS27670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_169951662.1"
                     /transl_table=11
                     /translation="MAYERDLWGAGDAYEAYVGRWSRHVAEVFLRRLEPPAGLRWLDVG
                     CGTGALTASVLATTDPASVVGVDTAQGFLAGARARITDGRANFLAGEAGALPLSGHGFD
                     AVVSGLVLNFVPDPRRAVAEFARVCRPGGVVAAYVWDYAGGMAMMRRFWDAAAILDPAA
                     AELDQGQRFPLCAPEPLAQLWAEAGLERVTVWAIDVPTVFADFDDYWEPFLGGQGVAPK
                     YVASLPEQRRHALRDLLRTRLPAGPDGSIPLAARAWAVRGVAGADRPGG"
     gene            complement(3198..3521)
                     /locus_tag="HHX31_RS27675"
     CDS             complement(3198..3521)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="HHX31_RS27675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_169951664.1"
                     /transl_table=11
                     /translation="MSQWGDSGPCNPHAPGPTNPSGLHGHVFNICTDRRRRRLGLARVC
                     LDALLGWYRTETEVRTIDLNATAYGIELYQSFGFDAPRYPALQLRLGPPLGRGFTSGQT
                     SNR"
     misc_feature    complement(3546..3562)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.56"
                     /tool="antismash"
     misc_feature    complement(3551..3564)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.78"
                     /tool="antismash"
     gene            3646..4080
                     /locus_tag="HHX31_RS27680"
     CDS             3646..4080
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.5"
                     /locus_tag="HHX31_RS27680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_169951665.1"
                     /sec_met_domain="PF07366 (E-value: 9.1e-20, bitscore: 64.3,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVLRAVDRLRQAINRHDLDALARCFDERAVLVAPDGIAECREE
                     IASYYSQWMEAYPNMVITPQSVTMFADTVAAEFTISGTHKGPLLVPGGDVLEATGRPVL
                     VRSCSFSTVEDGLILSHRLFYDQLEMAAQIGGFLSFPDPS"
     misc_feature    complement(4148..4162)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.63"
                     /tool="antismash"
     misc_feature    complement(4319..4335)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.41"
                     /tool="antismash"
     gene            4382..6175
                     /locus_tag="HHX31_RS27685"
     CDS             4382..6175
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013504.5"
                     /locus_tag="HHX31_RS27685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_169951667.1"
                     /transl_table=11
                     /translation="MPFGHHRFVRRIRTAVAAVVPAAALAVAGPVLGTTPADAAVTCRV
                     TYTSTQWGTGSGGFTAAVDVKNSGDPLPDWTLTFTFPSSQRVSQGWSARWSQSGARVTA
                     RSESWNRPVASGGSVQIGFNGTWTGSNPPPTDFAVNGVPCQVAGASPSPSPSPSPSPSP
                     SASPSASPDVPVDNPFAGVTGYVDPGWAADVESSAVRVDDAAAEKMRGLKTTSTAVWLN
                     RIADVTGGSGVARTLKDHLDTAVEQGAGYITLVLHNLPDRDCRSRVSDAELHEQDNGLH
                     RYKTEYVDAIAALLAEPEYRNLRVAAVIEPRALLDLVVGGALDTFPCEQAAASGVYVMG
                     IRYALDTLAPLPNVYTYLDAGSAGWAGWESNFTALAALVTETARATSGGLAGLDGIATN
                     VGDYVPLVEPFLTDPHQTVMGQQLLLSRFIDWNPHLHERDYAVAMRAALIAKGFPSSLG
                     VVVDTSRNGWGGSARPTAVSTSGDLNTYVDESRVDRRPSRAAECNQKGAGLGARPVAAP
                     VPDVDAYLWIKRPGESDGAGGPLLPEGSDRLADYRCDPDGSLTPWSGGFRPTGALPNAP
                     LIGDWHHEQFVMLVDNAYPAL"
     gene            complement(6253..8787)
                     /locus_tag="HHX31_RS27690"
     CDS             complement(6253..8787)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040347.4"
                     /locus_tag="HHX31_RS27690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6185 family protein"
                     /protein_id="WP_169951668.1"
                     /transl_table=11
                     /translation="MRRLTSGAGTGLVGIPAVPALGLLILCPLILCALILCALMSGPAL
                     ADRAACEFGAPRSSWVETSVTIAERGHDTPVMTSTTRVGVPRDWAGSAALLGDGSAVGC
                     LLPEGGRTSVTTSADGAEVVVLSTLETRLEHYGPQWGGGSAGLWGSRESGGTRVVALLP
                     TTVDLPPGLAGARWRTVVVKTPESPARTVTPLPSQVLPGGTYVWRDGAAPPRVEVAVPL
                     SARAAFQRWVDLSGQRVLTVATYLGFALPYLLLAWLLVLLHRRSGDRDERALVRIVLGV
                     LAAITSAGAITVVLVLTEAGFPAHMIGLTDGAAIAVLAAPLCAAAWRTARARTPRAGSG
                     LAGSGFGGSRFSGSRFSGPAFGAVVLAGAALVAVCGFAPLSMRYLQNPGEPAWVASAVA
                     SALLITAAAWAVAVRAARVPGGRTPGAARALLSWSVPGLALLTLGFVAHAVVVRPADVL
                     PDVVVSPFLLLRSVAYLMWPLVVFLLLLLLRLRGRREESVGPLTTWLVVFLFVVGTIRW
                     PGTYAGMPVPLAALTGLAVLPLLLRLTRRAEAADPGVSRRRLAVIVEECRDLEAREKGL
                     RRRWASGDLDDDAYHRENGPVDDRIRVLRAEIGLDPGREDGLSPLDVALSRGPAGSWWA
                     NARLAARYASYVGAPAAVFLIWATWSTDSRGRDGWLDRLGEPNGFYGLAGDLIGGLLVW
                     PVAGFVLGALWRRLPGRRGYLKGVVPVLAYAAATGAHAVLNNVIGQAPVRGSLVRVLLL
                     FLVLTVVAVLMDARTLQTRPGGLASRLTPVAVVYRLGTAGSGIALVVAQAAAILGLWSQ
                     LRNGIDITSQVDTSTQASLPADAQLLQGRTGE"
     gene            complement(8875..9849)
                     /locus_tag="HHX31_RS27695"
     CDS             complement(8875..9849)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013618.5"
                     /locus_tag="HHX31_RS27695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lytic transglycosylase domain-containing protein"
                     /protein_id="WP_169951669.1"
                     /transl_table=11
                     /translation="MNDQSAVNSPPSRRRASMLASMLATVLAVVVPLAGCGGSVGEAAS
                     VAPRERLSPPAPAASASPAPEPSAPDLPAPDEAVPKDPARLAEALTSTVGRLRDAIDDW
                     RRTGDPAKGEAPEPVVLLSLYEQRIYRRLARDAKLASRAYAKLPKAVAARAKDNVTAIR
                     DLLSLAHPVSGPIKIKVRPAEPADALLAAFRRAERRFGVEWEVLAAVMLVETKFGRVRS
                     PSHVGARGPMQFMPGTWKAYGMGGDVDDIGDALLGAANYLHASGAPGDYRRALYAYNHS
                     QAYVEAVLLHARQMKQDIRNYYAYYTWQVYVITTKGERRLTGP"
     aSDomain        10001..10282
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX31_RS27700_Pantocin_Microcin_RRE.1
                     "
                     /evalue="4.00E-23"
                     /identifier="RREFam017.1"
                     /label="HHX31_RS27700"
                     /locus_tag="HHX31_RS27700"
                     /protein_end="94"
                     /protein_start="0"
                     /score="72.4"
                     /tool="antismash"
                     /translation="MRLPRVKSEHRPHRYDDGTIRIGGEIYGIAAEIADPYGWVWTALT
                     LMDGTRSRDEIAERLRLAHPEVPDAVSIVEQLVATRYLEDAAAVPPDGL"
     gene            10001..11158
                     /locus_tag="HHX31_RS27700"
     CDS             10001..11158
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013094.5"
                     /locus_tag="HHX31_RS27700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HesA/MoeB/ThiF family protein"
                     /protein_id="WP_211590408.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 2.6e-22,
                     bitscore: 72.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 3.3e-48, bitscore: 157.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLPRVKSEHRPHRYDDGTIRIGGEIYGIAAEIADPYGWVWTALT
                     LMDGTRSRDEIAERLRLAHPEVPDAVSIVEQLVATRYLEDAAAVPPDGLTERELDRYSR
                     NHAFFRAVDAAPGAHGWETQVRLKSARVVVLGLGGTGSHAAWALAAVGVGTIHCVDPDV
                     VELSNLNRQVLYGEQDVGRPKAEAAVARLRTVNSDIRVTSELRRIGSRRQLDDLIAGYD
                     ALALCADRPTGHGIRVWANRACAAANIPWAGGGYSGPLVTVGCFAPGVGACYECLSSGE
                     EARRRPGTPVDLGGPGVIATSAGVSGQLVAHALIGLLTGVPVPPAGTIQGVNLIAPDHH
                     VWVRHPPRPGCPVCGTPGPYGGSEHDFIPADEPNRHGMNEGRILD"
     misc_feature    11168..11183
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            11233..11358
                     /locus_tag="HHX31_RS35355"
     CDS             11233..11358
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS35355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_283244645.1"
                     /transl_table=11
                     /translation="MNTNEHETEPADETAAPAKTKITIRLLDKIETTTSSNSVGN"
     gene            11454..12125
                     /locus_tag="HHX31_RS27705"
     CDS             11454..12125
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF045158.2"
                     /locus_tag="HHX31_RS27705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6879 family protein"
                     /protein_id="WP_169951671.1"
                     /transl_table=11
                     /translation="MAHAGDIFDEVRRAEAPVLSAADYQAEFTEEFERAPDGVWKLERA
                     QEFFEPDVASWRAMMAGDWDGSLAMLEELREFLFTYYKTRPEARRIRIVETPLTPYLQW
                     ELHVLAVRATAGERPRVLHADAVRELERGAPLPEIVVLGPSLLYEVLYDEIGAHVGARR
                     ITDPGLVGPCLAAIRQLYGRGEDVRAYVEREVAPLPPPVISESARALLPGYSHHTGTIR
                     P"
     gene            12148..13332
                     /locus_tag="HHX31_RS27710"
     CDS             12148..13332
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS27710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_211590409.1"
                     /transl_table=11
                     /translation="MAEATVVRLRELAFRQDGSQWIVGRPDGDEFVAVPYEGMRAIELL
                     SAGATVEEAERRLRAETGADLDVGDFVRALGELGFLNEPGGTAAPAGPPTLPRLRPRHV
                     RWTLHPLLHLPVAGLVAAGITAAVVRPETLPGWRDLLWSERGTLVLASQIAVGWGLIFL
                     HEMAHLSTARAAGVPGRIRLGTRLQFLAVQTEVSGVWLAGRRVRLTVYLAGMATDAAAC
                     AAALLLTAAVGRHPALSMVALTSLGMLARQFLVFMRTDVYFLLQDLSGCRNMYGDASAY
                     VRHLALRLLRRPSPDPLARLPRKERRALRAYALLLVAGTAACLGVAFAVTAPATLTLLD
                     RAVRGLADPVDPVARLDAAAVLLSAVAFQAIWARAWWRRHGPRVRRALRTRLGR"
     gene            complement(13333..14217)
                     /locus_tag="HHX31_RS27715"
     CDS             complement(13333..14217)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: TD (2-103). E-value: 1.3e-07. Score:
                     23.0. Matches aSDomain: nrpspksdomains_HHX31_RS27715_TD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016228.5"
                     /locus_tag="HHX31_RS27715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_169951675.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.4e-20, bitscore:
                     65.7, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILITGASGYVGGVVAEHLVRADHEVVALARSDEARERVEGLGA
                     KAVAGSLRDLDVLRGAAASAEAVVHAAVDYADPGMGEIEHDALAALLDGLHDGGAFVYT
                     STGLVYPDRQGATVDEDHPVTPETSAQPYKVLGERQVLAAGHVAGTVIRAALVYGRGGS
                     GLLQGLIGAGRQSGMVPYIGDGANEWSSVHVDDLAALYVAALERREPGVVVNAASAERT
                     PIRRMAEAVAGLTGAQAVSLTLEQGTAAMGPLAATLTRSSPLDASRARRLFGWAPRRPG
                     LVEELTSGSYARS"
     aSDomain        complement(13909..14211)
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX31_RS27715_TD.1"
                     /evalue="1.30E-07"
                     /label="HHX31_RS27715_TD.1"
                     /locus_tag="HHX31_RS27715"
                     /protein_end="103"
                     /protein_start="2"
                     /score="23.0"
                     /tool="antismash"
                     /translation="ILITGASGYVGGVVAEHLVRADHEVVALARSDEARERVEGLGAKA
                     VAGSLRDLDVLRGAAASAEAVVHAAVDYADPGMGEIEHDALAALLDGLHDGGAFVY"
     CDS_motif       complement(14119..14208)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX31_RS27715_0001"
                     /evalue="3.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="HHX31_RS27715"
                     /protein_end="33"
                     /protein_start="3"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LITGASGYVGGVVAEHLVRADHEVVALARS"
     misc_feature    complement(14203..14218)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.56"
                     /tool="antismash"
     misc_feature    complement(14242..14257)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            14379..15230
                     /locus_tag="HHX31_RS27720"
     CDS             14379..15230
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017542087.1"
                     /locus_tag="HHX31_RS27720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_169951677.1"
                     /transl_table=11
                     /translation="MDKHGLARFLRSKRESIDPADVGLPLGRRRRTPGLRREEVAQLAY
                     VSVDHYTRLEQARGRHPSRRVLDGIARALRLSDQERAHLFHLAGELEESRSGEPVSEVR
                     PSTLSLVNRLTDAAAIVVDDTCRVLAWNPLAAALFEDFSALAGQERNVIRRYFLHPDPE
                     RRHYGMSSPERFAVTAVSYLRVAATRYPDSHELNSLIAELVAGSEDFARLWNSQRFHIE
                     RHLHQTVRHPRVGPIELDFDVLTVPDQEQQVVIFTAEPGSTAYESLQFLKVVGAERTPA
                     DA"
     misc_feature    complement(15269..15282)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.79"
                     /tool="antismash"
     misc_feature    complement(15270..15283)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.49"
                     /tool="antismash"
     misc_feature    15325..15339
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.68"
                     /tool="antismash"
     gene            15358..15786
                     /locus_tag="HHX31_RS27725"
     CDS             15358..15786
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890617.1"
                     /locus_tag="HHX31_RS27725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_169951679.1"
                     /transl_table=11
                     /translation="MTHEEKRAWIRLVVAVVAYAVYVVTILRRADGGPLSDVPYAAALL
                     WTIGGAIGAAILAEIGMAIVNPRASRVIDVRDKEIGRLGDYTGQAFVAIGALAAMLMAV
                     AEWDGFWIANVIYLFFVLSAILSDTTKIILYRRSVPEW"
     gene            15780..16013
                     /locus_tag="HHX31_RS27730"
     CDS             15780..16013
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890616.1"
                     /locus_tag="HHX31_RS27730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_030510150.1"
                     /transl_table=11
                     /translation="MVKPTRVTNRIRALRFAHDEMTQAELAERIGVTRQTVIAIEQGRY
                     SPSLEMAFRIARVFGAPLDDVFQYPDLPEETK"
     gene            16010..16984
                     /locus_tag="HHX31_RS27735"
     CDS             16010..16984
                     /NRPS_PKS="Domain: PKS_ER (12-322). E-value: 3.3e-45.
                     Score: 146.5. Matches aSDomain:
                     nrpspksdomains_HHX31_RS27735_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890842.1"
                     /locus_tag="HHX31_RS27735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_169951681.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 9.1e-20, bitscore:
                     64.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIVQDAYGPADVLELRDVDRPSIRGDEVLVEVRAAAVDPGVWV
                     LMTGTPYLARAGFGLRRPKVPVRGRDVAGVVTAVGAGVTRFRPGQEVYGACPNGSLAEF
                     ARAPQARLAPKPANLTFEQAAAVPVSGMTALQAVRDVAGVRPGQRVLVIGASGGVGSFA
                     VQIAKALGASVTGVCATAKADFVRSLGADDVIDYTREEIDHDGARYDVVVDTAGNRPLS
                     LLRRVLTPRGTLAIVGGGHTAYRFTGGMGRTFRAPLLSAFTRQRLRPMFSRERADHLEE
                     LTRLIESGAVIPAVDRTYPLAAAPDAIRHLMEGHPAGKVVVTV"
     aSDomain        16046..16975
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX31_RS27735_PKS_ER.1"
                     /evalue="3.30E-45"
                     /label="HHX31_RS27735_PKS_ER.1"
                     /locus_tag="HHX31_RS27735"
                     /protein_end="322"
                     /protein_start="12"
                     /score="146.5"
                     /tool="antismash"
                     /translation="DVLELRDVDRPSIRGDEVLVEVRAAAVDPGVWVLMTGTPYLARAG
                     FGLRRPKVPVRGRDVAGVVTAVGAGVTRFRPGQEVYGACPNGSLAEFARAPQARLAPKP
                     ANLTFEQAAAVPVSGMTALQAVRDVAGVRPGQRVLVIGASGGVGSFAVQIAKALGASVT
                     GVCATAKADFVRSLGADDVIDYTREEIDHDGARYDVVVDTAGNRPLSLLRRVLTPRGTL
                     AIVGGGHTAYRFTGGMGRTFRAPLLSAFTRQRLRPMFSRERADHLEELTRLIESGAVIP
                     AVDRTYPLAAAPDAIRHLMEGHPAGKVVV"
     misc_feature    16058..16060
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       16214..16249
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX31_RS27735_0001"
                     /evalue="2.90E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="HHX31_RS27735"
                     /protein_end="80"
                     /protein_start="68"
                     /score="10.6"
                     /tool="antismash"
                     /translation="GRDVAGVVTAVG"
     CDS_motif       16448..16510
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX31_RS27735_0002"
                     /evalue="9.10E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="HHX31_RS27735"
                     /protein_end="167"
                     /protein_start="146"
                     /score="18.2"
                     /tool="antismash"
                     /translation="GQRVLVIGASGGVGSFAVQIA"
     gene            complement(16991..17392)
                     /locus_tag="HHX31_RS27740"
     CDS             complement(16991..17392)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.5"
                     /locus_tag="HHX31_RS27740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_169951683.1"
                     /transl_table=11
                     /translation="MTLTADDRTAITDLINLHGHLTDSGDFDGLREVFVPDVVYDVGDL
                     GGGVIVGLAALRDAALALGEGNPVAHHVTNIVVTEAADGRARAISKGIGVNADGTTGSV
                     TYEDTLVRDDHGWRISRRTVRARRMPLTS"
     gene            17504..18088
                     /locus_tag="HHX31_RS27745"
     CDS             17504..18088
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF044515.2"
                     /locus_tag="HHX31_RS27745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_169951685.1"
                     /transl_table=11
                     /translation="MTSSGPEPAPPGRTRRADASRNAALLLAAARELVAESGPEVALDE
                     VARRAGVGNATLYRHFPTRADLLVAVYADEVAELCRRGADLPPGLSPADALFSWLDAFV
                     VHVATKRPLALAATEGPTGRRSALFDQWHTSIHATASDLLRRAQDAGAVRPGLTVTDLL
                     ALAGGAALTGTDVAHARRLTALLRRGLETGD"
     gene            18172..19098
                     /locus_tag="HHX31_RS27750"
     CDS             18172..19098
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657876.1"
                     /locus_tag="HHX31_RS27750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SPFH domain-containing protein"
                     /protein_id="WP_169951687.1"
                     /transl_table=11
                     /translation="MTDLQIAVDMPAPQTHERTARATAGWPMLILALVGLLIPVALIPI
                     GAVLAAEGSVGAGTALIVAGTLLLLAAVVVLTGLTAVAPGEARVIQLLGRYVGTVRTPG
                     LRFVAPFTQKRRVSTRIRNHETDITKVNDADGNPIEMAAVVVWQVEDTAKAVFEVDDFV
                     EFVAFQTETAVRHIAGSYPYDGHDDMLSLRQNADEITGRLSAEIQARVASAGVKVIESR
                     ITRLAYAPEIAQAMLRRQQAGAVVAARQRIVDGAVGMVEAALARLDAHNVIELDEERKA
                     TMVSNLLVVLCGDRDVQPVVNTGSLYH"
     gene            19102..19344
                     /locus_tag="HHX31_RS27755"
     CDS             19102..19344
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634332.1"
                     /locus_tag="HHX31_RS27755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_169951689.1"
                     /transl_table=11
                     /translation="MASERKSILLRLDPAVHDALARWAGDELRSTNAQIEFLLRRALSE
                     AGRLPGNAARIPRRGRPAKKETPAPESPAAGPPDD"
     gene            19360..19986
                     /locus_tag="HHX31_RS27760"
     CDS             19360..19986
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852254.1"
                     /locus_tag="HHX31_RS27760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_169951691.1"
                     /transl_table=11
                     /translation="MDVPGSLTAQLYLLAYDPRKERVVTNYRLPYLLRAAALTDLLLMG
                     RIADDDGKVRVVSKDRLGDPVLDGLLHQLAESGPRPWRHWIGKDGRATVRAVRDELEMR
                     RWVRVELRQPFLIFNRSAVRVRDTRVVKRLAARVAGALSGPVSRIGDRDAALVGLAAAA
                     DLGTVLPRAKQRAHKRRIEQLTERGGPAAAALRKVIQQARGASGG"
     gene            complement(20014..20661)
                     /locus_tag="HHX31_RS27765"
     CDS             complement(20014..20661)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891874.1"
                     /locus_tag="HHX31_RS27765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HNH endonuclease family protein"
                     /protein_id="WP_249346740.1"
                     /transl_table=11
                     /translation="MAVTMIYLHRTLRVAALSCLLLPVTAVVLAPQAAADTGSRARRML
                     DQLKVAKPLSIRGYSHQRFQPRWAHHKGTCDAREVVLARQGRGVRRNAACQAVKGVWYS
                     PYDGKVLKSVKQTDVDHVVPLAYAWRSGAKRWSQAKRRAFANDLTRPELVVVSHSVNMA
                     KGGQGPQSWRPPRRAYWCRYATSWITVKRHYRLFVTKKEKVALLNMLRTCRR"
     misc_feature    20822..20840
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.1"
                     /tool="antismash"
ORIGIN
        1 gcgggggcgc gacgagcatg cccgcgacgt cgctgagctt gccggtgacg acccccggcc
       61 acgcgggttt cagcaccagg tcgttgacga tcagcacccc gatcgccgcg acggtcaccg
      121 ggtggccgag ccaggccgcc tgcgcgccgg acacggctcc gctcggtcgc tcgcggtcgt
      181 gctgaagacg atcacgcacc cgccgatcgt aaacgcgtgt tcaccggtgc ggcagtgaat
      241 tcccggcacg gccgcaccgc cgtacgggga acggatcgac cgacgagcgg cctacggggt
      301 gctgacgggc gacggcccct tggtgaggat gacaggggat gggccgccca gcgccaggcg
      361 ggcgggcaac cccgccgtcc ggctctgacg ttcggcacgt gccagaccgc tcaccgtcag
      421 cgtcccgtcg cacggccatt cgtccgcccg ctcggccggc cggtcccaca cgaccagcgg
      481 gccgtccacc cgcgcggcca gcagatactg cagcggtgtg cgcggcagga acaggtcgac
      541 gtcgggcgtc gcgcgccgta cggcccgggg gagcaccggc tcgcgcagcc gcaccagcgt
      601 ggccggctcg gtccgctcga ccagtgcgcg gatgtcgggc gggagcaggt tcgcgacctc
      661 cctggccatc gagacgttcc tgaccagcac gcggacccgt cctgacgcgc cgtccatgcg
      721 cgccagcgcg tgctcggacc tggcgtcgca gacgacctgg tcggcgaaca ggtcgtgcag
      781 gccggccact cccccggctc cgatcgccgc gacggccgcc gccagggcgt cctggcccgt
      841 gaccccattc cagcggaggc cggggccgca cgccgtacag cccgtcgcgg cggacacgga
      901 cctacgcggg tgcggcccgc ggcactcctg cccgcagtcc gcgcacagga cggcggagtg
      961 cgccggtccg cccggcggcc ggcagtcgtc gcagcagacg agcggataca tgtaccggcg
     1021 gccggcccgg tcgaacagct cacggacgca ggcggaacag agcccgtgct cgcttcgccg
     1081 agcgccgggg gaagctgaga tgaccacgga agccgcactg cccgccgccg gtctctctat
     1141 tcacacccgt cacaccgata tcacggcggt cagatccgct cgacgccgat gtggacgcgg
     1201 ctgtgccgcg gccgctccac ctcgtccagc acggcgaccg cgagatccgc gtaggagatc
     1261 cggctccccg cgtctcccgg cgcgacgcgg tacccgccgg tgcggacccc gtcgtggtcg
     1321 aagtcgccgg acgggctgat cacgagccag tccaccgggg tgaccgcctc acgcaggacg
     1381 gcgtcgcccg cctcgtgacc gaggtagaac tcgcggtact cctgcgggta ccccggcgtg
     1441 tccatcagca gcgtgccctc ggcggtccgc agaccggtgg ccaggcccac cgcgatcagc
     1501 cgcgggacac cggcccgctc cagcccgccg agcagcgcgc gggccgccgc cgggaagaac
     1561 tccatgggcg gtgcggtcag gtcggcggcg gcgttgaccg ccgcccggtg ccccgccgcg
     1621 atccgggcga ccgcgtccgt gtccgtcacg tcgcccgcga cgacgtcgtc caccgccggg
     1681 cttccctccc cggagacgta cgcggccggg tcgcgtacca ccgccgtcac ccggtgcccc
     1741 cgctcacggg cctcccttac caccgcgcgg cccgccctgc cgcccgctcc gaacaccacg
     1801 atcgcgttca cgtccgcccc tctcctcggg ggaccggccc cacggccggt cacagcgacg
     1861 gacggtatcc gtatgggcgg ttacctccgg gtcaccggtt agcgtggtgg gcgtgaccga
     1921 accgctcgat ccggacatgt tcgatccgct ctgcccgtcc ggcctgatgc ccatccggct
     1981 cggcgacaag tggtcgggca tgatcattcg ctgcctggag cacgggcccc ggcgcttctc
     2041 cgaactgcgc gttcccctgc gcggcatctc ggccaaggtg ctcacccagt cgctgcgcgc
     2101 gctcgaacgc gacggcttcg tcctgcgtac ggcccatccc ggggccgtcc agcgggtcga
     2161 gtacgcgctg acgccactcg gccggagcct gatcgaaccg ttgaacacca tgtgcgcgtg
     2221 ggccgaggac cactgggagg agcttctcga cgcccgcgag gcgtagccgt acgggcctgc
     2281 tcagaaccgt ccgtagcggt cggccggagg atcagccgcc gggacggtcc gccccggcga
     2341 cgcctcgtac cgcccacgct cgggcggcga gtgggatcga cccgtccggg ccggcgggca
     2401 gacgggtgcg cagcaggtcg cgcagggcat gacgccgctg ttccggcaag gacgcgacgt
     2461 acttgggggc caccccctga ccgccgagga acggctccca gtagtcgtcg aaatcggcga
     2521 acacggtcgg cacgtcgatc gcccacaccg tcacccgctc aagacctgcc tcggcccaca
     2581 gctgtgcgag cggttccgga gcgcacagcg gaaaccgctg accctggtcc agctcggccg
     2641 cggccgggtc caagatggcg gcggcgtccc agaaacgccg catcatggcc atgcccccgg
     2701 cgtagtccca gacgtaggcg gcgacgacgc cgccgggcct gcagacccgg gcgaactcgg
     2761 cgacggcacg gcgaggatcc ggaacgaagt tgagcaccag cccgctcacc acggcgtcga
     2821 atccgtgacc ggaaagcggc agtgcgcccg cctcgccggc caggaagttc gcccgcccgt
     2881 cggtgatccg cgcacgcgcg ccggccagga acccctgcgc cgtatccacg ccgacgaccg
     2941 acgccgggtc cgttgtcgcc agcacgctcg cggtcagcgc cccggtgccg cagcccacat
     3001 cgagccaccg taggcccgcc ggaggttcca gccggcgcag gaacacctcg gcgacgtggc
     3061 ggctccaccg gccgacgtag gcctcgtacg cgtcgccggc gccccacagg tcgcgctcgt
     3121 acgccatcac gcgactatac gtcggcgatc ggccgccggg cagggcgcga gcgtacgccg
     3181 acgcaccgga ccgtccacta ccggttcgac gtctggccac tcgtgaagcc gcgcccgagc
     3241 ggcgggccca gccgcagctg gagagccggg tagcgaggcg cgtcgaaacc gaaggactgg
     3301 tacagctcga tgccgtacgc cgtggcgttg aggtcgatcg tccggacctc ggtctcggtg
     3361 cggtaccagc cgagcagcgc gtcgagacag acccgcgcga ggccgaggcg gcggcgccgc
     3421 cggtcggtgc agatgttgaa gacgtggccg tgcaggccgc tcgggttcgt gggtcccggc
     3481 gcgtgggggt tacagggtcc tgagtccccc cactggctca ctcgccctgc tgagagccag
     3541 ctgagctggg atatcgtaaa aaagccgccc ctgtccggac gccgccacac cggtcacgat
     3601 gcgggcgcac catacggccg ctctcaccgg gggaagggac gtcctatgtc ggaagtgctc
     3661 cgtgccgtgg acaggctgag gcaggcgatc aaccgccacg acctggacgc cctggcgcgg
     3721 tgtttcgacg agcgggccgt actcgtggcc ccggacggca tcgccgagtg cagggaggag
     3781 atcgcctcct actacagcca atggatggag gcgtacccca acatggtgat cacgccccag
     3841 tcggtgacca tgttcgcgga caccgtggcg gcggagttca cgatcagcgg cacgcacaag
     3901 gggccgctgc tcgtccccgg cggggacgtt ctcgaggcga ccgggcggcc cgtcctcgtc
     3961 cgctcgtgca gcttctccac ggtggaggac gggctgatcc tcagccaccg gctcttctac
     4021 gaccagttgg agatggccgc ccagatcggc ggcttcctca gcttccccga cccctcgtaa
     4081 cgggctctcg cgcgggggtg cgggcggccg ccccgctcgc ctcgggcatc gtggacccgc
     4141 ccggcccgag gctctgaata ttcaccgcgt tcgagcaccg cccgccgatc ccgtacggcg
     4201 tttcgcgagg tgccgtacgg ttcgagcatc cctgtcacgg aaagacccat ttccacttcg
     4261 gcgattcgta tacacgagcc gggcgattgc cgagtctggg agcgtcggcg cccttgggtg
     4321 caccggaaac gggcgccgga tgccgggacc ttggcaccac gcccactgga gacgatcgcc
     4381 tatgccattc ggccaccatc gtttcgtccg caggatccgc acggccgtcg cggcggtcgt
     4441 ccccgccgcg gcgctggccg tggccggacc ggtcctgggc acgacgcccg ccgacgccgc
     4501 ggtcacctgc cgggtgacct acacgagcac ccagtgggga acgggctcgg gcggcttcac
     4561 ggccgccgtc gacgtgaaga acagcggcga cccgctcccg gactggacgc tgaccttcac
     4621 cttcccgagc tcccagcgtg tctcgcaggg ctggtcggcc cggtggagcc agtccggcgc
     4681 ccgggtcacg gccaggagcg agtcgtggaa ccggcccgtc gcctcgggcg gctccgtcca
     4741 gatcggcttc aacggcacct ggaccgggag caacccgccg cccacggact tcgccgtcaa
     4801 cggcgtgccc tgccaggtgg cgggcgcctc cccgagcccg agcccgtcgc cgagcccgtc
     4861 gccgagcccg tccgccagtc ccagtgcgag cccggacgtg ccggtggaca acccgttcgc
     4921 cggcgtcacg gggtacgtcg acccgggctg ggcggccgac gtcgagtcct ccgccgttcg
     4981 ggtggacgac gcggccgcgg agaagatgcg cggcctcaag acgacgtcca ccgcggtctg
     5041 gctgaaccgg atcgcggacg tcaccggcgg ctccggagtc gcccgtacgc tgaaggacca
     5101 cctcgacacc gccgtcgagc agggcgccgg gtacatcacg ctcgtgctcc acaacctgcc
     5161 ggaccgcgac tgccggtcgc gggtctccga cgccgagttg cacgagcagg acaacggcct
     5221 ccaccgctac aagaccgagt acgtcgacgc catcgccgcg ctcctggccg agcccgagta
     5281 ccggaacctg cgcgtcgcgg ccgtcatcga accgcgggcc ctgctcgatc tcgtcgtggg
     5341 aggcgcgctg gacaccttcc cgtgtgaaca ggcggcggcg tcgggcgtgt acgtgatggg
     5401 catccggtac gccctcgaca cgctggcgcc cctgcccaac gtctacacgt acctggacgc
     5461 gggcagcgcg ggatgggccg gctgggagtc gaacttcacg gcgctcgcgg ccctcgtcac
     5521 cgagaccgcg cgcgccacgt cggggggcct cgccggcctc gacggcatcg ccaccaacgt
     5581 cggggactac gtccccctcg tcgagccgtt cctcaccgac ccccatcaga cggtgatggg
     5641 ccagcagctc ctcctgagca ggttcatcga ctggaacccc cacctgcacg aacgggacta
     5701 cgccgtcgcc atgcgtgccg cgctgatcgc caagggcttc ccgagctcgc tcggcgtggt
     5761 cgtcgacacc tcgcgcaacg gctggggcgg gtccgcccgg ccgacggctg tgagcacctc
     5821 cggcgacctc aacacgtacg tggacgagag ccgcgtcgac cggcgtcctt cgcgggccgc
     5881 cgagtgcaac cagaagggtg cggggctggg ggcccgtccg gtcgccgcgc ccgttcccga
     5941 cgtcgacgcc tacctctgga tcaagcggcc gggcgagtcg gacggcgccg gcgggccgct
     6001 cctgcccgag ggctccgacc ggctggccga ctaccggtgc gaccccgacg gttccctcac
     6061 gccctggtcc ggcgggttcc ggccgaccgg cgcgctcccc aacgcgccgc tgatcggcga
     6121 ctggcaccac gagcagttcg tgatgctggt ggacaacgcc tatcccgccc tctgaggcgt
     6181 ggcgcggctc cggcgccggg cgccggagcc gcccgcactc cgcgcctcgc ggttcccgat
     6241 cggcgtgtac ggctactcgc ccgtacgccc ctggagcagt tgcgcgtcgg cgggcagcga
     6301 cgcctgggtg gaggtgtcca cctgtgaagt gatgtcgatg ccgttcctca gctggctcca
     6361 caggccgagg atggccgccg cctgcgcgac gacgagcgcg atcccgctgc ccgccgtacc
     6421 gagccggtag acgacggcca ccggggtgag ccgcgacgcg agaccacccg ggcgggtctg
     6481 gagggtccgc gcgtccatga ggacggcgac gacggtgagc accaggaaca gcagcagcac
     6541 ccgcacgagc gagccgcgca cgggggcctg gccgatgacg ttgttcagca cggcgtgcgc
     6601 ccccgtcgcc gcggcgtacg cgaggaccgg cacgacgccc ttcaggtagc cgcgcctgcc
     6661 gggcaggcga cgccacagcg cgcccagcac gaagcccgcc accggccaga ccagcagccc
     6721 gccgatcagg tcgccggcca ggccgtagaa cccgttcggt tcgccgagcc gatccagcca
     6781 gccgtcgcgc ccccggctgt cggtgctcca ggtggcccag atgaggaaca cggcggcggg
     6841 cgcgcccacg taggaggcgt accgcgcggc gagccgcgcg ttcgcccacc acgacccggc
     6901 cgggccgcgc gacagcgcca cgtcgagcgg gctgagcccg tcctccctgc cggggtcgag
     6961 gccgatctcc gcgcgcagca cgcggatccg gtcgtcgacc ggcccgttct ccctgtggta
     7021 ggcgtcgtcg tccaggtcgc ccgaggccca gcgccgccgc aggcccttct cccgcgcctc
     7081 caggtcccgg cactcctcga cgatcacggc gagccttcgc cgcgacactc ccgggtcggc
     7141 ggcctccgcc cgtcgcgtga gccgcagcag caggggcagc accgcgaggc cggtgagcgc
     7201 ggcgagcggg actggcatcc ccgcgtacgt ccccggccac ctgatcgtgc ccacgacgaa
     7261 caggaagacg acgagccacg tggtgagcgg cccgacggat tcctcacgcc gcccgcgcag
     7321 gcgcagcagc aggaggagca ggaacaccac cagcggccac atcaggtacg cgacgcttcg
     7381 cagcaggagg aagggcgaca ccaccacgtc cggcaggacg tccgcggggc gcacgacgac
     7441 cgcgtgggcc acgaacccca gtgtcagcag cgccagcccg gggacgctcc agctcagcag
     7501 cgcacgcgcg gcccccggcg tccgcccgcc ggggacgcgg gcggcgcgga ccgcgaccgc
     7561 ccacgccgcc gcggtgatca gcagcgccga cgcgacggcc gacgcgaccc acgcgggctc
     7621 ccccgggttc tggagatacc gcatggacag cggcgcgaag ccgcagacgg cgacgagtgc
     7681 cgctccggcg agcaccaccg cgccgaacgc gggaccgctg aaccgcgaac cactgaaccg
     7741 cgaaccgccg aatccggaac cggccagccc cgaaccggcg cgcggggtcc gggcacgcgc
     7801 cgtccgccac gcggccgcgc acagcggcgc cgccaggacg gcgatcgccg cgccgtccgt
     7861 caggccgatc atgtgggctg ggaagcccgc ctcggtgagc accaggacga ccgtgatcgc
     7921 gcccgccgac gtgatcgcgg ccaggacgcc gaggacgatc ctgacgaggg cgcgctcgtc
     7981 ccggtcgccg gagcgccggt ggagcagcac gagcagccag gccagcagca ggtacggcag
     8041 ggcgaagccc agataggtcg cgaccgttag cacgcgctgc ccgctcaggt cgacccagcg
     8101 ctggaacgcc gcccgcgcgg acagcggcac ggcgacctcg acgcggggcg gggcggcgcc
     8161 gtcccgccag acgtaggtgc cgccggggag cacctgcgac ggcagaggcg tcaccgtgcg
     8221 cgccggggac tccggcgtct tgacgaccac ggtccgccag cgcgctccgg cgagcccggg
     8281 cggcaggtcc acggtcgtgg gcagcagcgc gacgaccctg gtcccgccgg actcgcggct
     8341 cccccacagc ccggcggacc ccccgcccca ctgcggaccg tagtgctcca ggcgggtctc
     8401 cagcgtgctg agcaccacca cctcggcgcc gtcggccgac gtcgtgacgc tcgtcctgcc
     8461 gccctcgggc agcaggcagc cgaccgcgct cccgtcgccg agcagcgcgg cggaccccgc
     8521 ccagtcgcgg gggacgccga cccgcgtcgt actcgtcatc acgggcgtgt cgtggccgcg
     8581 ttccgcgatg gtcacggacg tctccaccca ggacgagcgg ggagccccga actcgcaggc
     8641 cgcccggtcc gcgagcgccg ggcccgacat cagcgcacac aggatcagcg cacacaggat
     8701 cagcgggcac aggatgagca ggccgagcgc cggcacggcg gggatcccca cgagcccggt
     8761 ccccgctcca ctcgtcagcc gacgcacaac cgacctcccg gacgcgatcg cttcccccga
     8821 aggatgagtc gtacggaaag ccgcgtgggt tacgggcgat ccctcacagg accgtcaggg
     8881 gccggtcagc cgccgctcgc cctttgtggt gatcacgtag acctgccagg tgtagtaggc
     8941 gtagtagttc ctgatgtcct gcttcatctg gcgcgcgtgc agcagcacgg cctcgacgta
     9001 cgcctgggag tggttgtagg cgtacaacgc gcgccggtag tcgccgggcg cgcccgaggc
     9061 gtggaggtag ttggccgcgc cgagcagggc gtcgccgatg tcgtcgacgt cgccgcccat
     9121 gccgtacgcc ttccaggtgc ccggcatgaa ctgcatcggt cctctggcgc ccacgtggct
     9181 cggcgagcgg acccggccga acttcgtctc gacgagcatc accgcggcca gcacctccca
     9241 ctccacgccg aaccggcgct cggcacgccg gaaggccgcg agcagcgcgt cggccggctc
     9301 cgccggcctc accttgatct tgatcgggcc gctgacgggg tgggcgaggg agagcaggtc
     9361 gcggatggcc gtcacgttgt ccttcgcccg cgcggccacc gccttgggca gtttcgcgta
     9421 ggcgcgggag gcgagcttgg cgtcgcgggc gagacggcgg tagatccgct gctcgtacag
     9481 cgacagcagc accacgggct cgggcgcctc ccccttcgcg gggtcgcccg tgcgcctcca
     9541 gtcgtcgatc gcgtcgcgca gccgtccgac cgtgctggtg agcgcctctg ccagccgcgc
     9601 ggggtccttc ggcaccgcct cgtcaggggc gggcaggtcc ggtgcggacg gctccggcgc
     9661 cgggctcgcg gaggccgccg gcgcgggcgg cgacaggcgc tcgcgcggag cgaccgaggc
     9721 ggcctcgccc accgagccgc cgcagcccgc gagcgggacg accacggcga gcacggtggc
     9781 cagcatggag gccagcatgg aggcccggcg gcgtgatggc ggtgagttca cggcagactg
     9841 atcgttcatc gtcaccaacg tatgccccac ggtgacgatc catgccctct tccccgggat
     9901 acggcgtccg cgacgcggga acgttttacg gccggccatt tccctcgcgc gtggaattcg
     9961 gtgttgactc acccagtcag cgcgcactaa acgtcgtcac gtgcgactgc cccgcgtgaa
    10021 atccgagcac cggcctcacc ggtacgacga cggcaccatt cgcatcggcg gcgagattta
    10081 cggcatcgcc gccgaaatcg ccgacccgta cggctgggtg tggacggcgc tcacgctgat
    10141 ggacggcacc cgctcccgcg acgagatcgc cgagcggctg cgcctggccc atcccgaggt
    10201 gccggacgcc gtgtcgatcg tggagcaact ggtcgccacc cgatacctgg aggacgccgc
    10261 cgcggtgccg cccgacgggc tgaccgagcg cgaactcgac cgttacagca ggaaccacgc
    10321 gttcttccgc gcggtcgacg ccgcgccggg cgcccacggc tgggagaccc aggtccggct
    10381 gaagtccgcg cgggtcgtgg tgctcggcct cggcggcacc ggcagccacg cggcgtgggc
    10441 gctcgccgcc gtcggcgtcg gcaccatcca ctgcgtggac cccgacgtgg tcgagttgtc
    10501 caacctcaac cgccaggtgc tctacggcga gcaggacgtg ggacgcccga aggccgaggc
    10561 ggccgtggcg cggctgcgga ccgtcaactc cgacatccgc gtcaccagcg aactccgccg
    10621 catcggcagc aggcggcaac tggacgacct gatcgcgggc tacgacgcgc tcgccctgtg
    10681 cgcggaccgg cccaccgggc acggcatccg ggtgtgggcc aaccgcgcct gcgccgcagc
    10741 gaacatcccc tgggccggtg gcggatacag cggcccgctc gtcaccgtgg ggtgcttcgc
    10801 gccgggggtg ggcgcctgct acgagtgcct gagcagcggc gaggaggcgc ggcgccgccc
    10861 cggcacgccg gtcgacctcg gcgggccggg ggtcatcgcc acctcggcgg gcgtgtccgg
    10921 ccagctcgtc gcccacgccc tgatcgggct gctgaccggt gtgcccgtgc cgccggccgg
    10981 caccatccag ggggtcaacc tgatcgcccc ggaccaccac gtgtgggtca ggcatccgcc
    11041 gcgtcccggc tgtccggtgt gcggcacacc cggcccgtac ggcggatccg agcacgattt
    11101 cattccggcc gatgagccaa atcggcacgg aatgaatgaa ggaagaatcc ttgactgatt
    11161 cctgtcaaag gcgaatcatg aacccgttct cgcgagaaga tccatgtccc ctcccatcca
    11221 gagaggaagc ggatgaacac gaacgaacac gagacagaac ccgccgacga gaccgccgcg
    11281 ccggcgaaga cgaagatcac catccggctg ctcgacaaga tcgagaccac gaccagcagc
    11341 aacagcgtcg gcaactgaac gaacgccggg cgaggcgcgc gggggcgccg cggggccgcc
    11401 cgcacgcctc gcccggtgag aaccggcacg aaggagcgcg cagggaggga agggtggcac
    11461 acgccgggga catcttcgac gaggtgcggc gggccgaggc gccggtcctg tccgcggccg
    11521 actaccaggc cgagttcacc gaggagttcg agcgtgcccc cgacggggtg tggaagctcg
    11581 aacgcgccca ggagttcttc gaacccgacg tggcgagctg gcgggcgatg atggccggcg
    11641 actgggacgg gtcgctcgcc atgctggagg agctgcggga gttcctcttc acctactaca
    11701 agacccggcc ggaggcccgc cggatccgca tcgtggagac gccgctcacc ccctatctcc
    11761 agtgggagct gcacgtcctg gccgtacggg cgacggcggg cgagcgtccc cgggtgctgc
    11821 acgccgacgc cgtacgtgag ctggagcgcg gcgcgccgct ccccgagatc gtcgtgctcg
    11881 gcccctcgct gctctacgag gtgctgtacg acgagatcgg cgcacacgtg ggcgcccggc
    11941 ggatcaccga tcccgggctc gtcggcccct gcctggccgc gatcagacag ctctacggcc
    12001 gcggcgagga cgtccgggcg tacgtcgagc gggaggtcgc cccgctgccg ccacccgtga
    12061 tctccgagag cgcacgcgcg ctcctgcccg gctactccca ccacaccggg acaatccgcc
    12121 cctgaatccc gcaccaggag gcccgtgttg gcagaggcca ccgtggtccg gctgcgcgag
    12181 ctcgcgttcc ggcaggacgg ctcgcagtgg atcgtcggcc gcccggacgg ggacgagttc
    12241 gtcgccgtgc cgtacgaggg gatgcgggcg atcgaactgc tgtcggcggg cgccacggtc
    12301 gaggaggcgg aacgccggct gcgcgcggag acgggggcgg atctcgacgt cggcgacttc
    12361 gtccgcgccc tcggcgaact gggcttcctc aacgagccgg gcggcacggc cgctcccgcc
    12421 ggaccgccga cactgccccg gctgcgcccc cggcacgtgc ggtggacgct gcacccgctg
    12481 ctccacctgc cggtcgccgg cctggtagcg gccggcatca cggcggcggt cgtgcggccg
    12541 gagacgctgc cgggctggcg cgacctgctg tggagcgagc ggggcacgct cgtgctcgcg
    12601 tcgcagatcg ccgtcggctg ggggctgatc ttcctgcacg agatggccca cctgtcgacc
    12661 gccagggcgg cgggggtgcc gggcaggatc cggctcggca cccggctgca gttcctggcc
    12721 gtgcagaccg aggtgtccgg cgtctggctg gccgggcggc gcgtccgcct gacggtctac
    12781 ctcgccggaa tggcgacgga cgcggcggcc tgtgccgccg cgctcctgct gaccgccgcc
    12841 gtgggccgcc accccgcgct gtcgatggtc gcgctgacct cgctcggcat gctggccagg
    12901 cagttcctcg tgttcatgcg caccgacgtc tacttcctgc tgcaggacct gagcgggtgc
    12961 cgcaacatgt acggcgacgc ctccgcgtac gtccgccacc tggcgctgcg gctgctccgg
    13021 cggccctctc ccgacccgct cgcccggctg ccgcgcaagg agcgccgcgc gctccgcgcg
    13081 tacgcgctgc tgctggtcgc gggcaccgcg gcctgccttg gtgtggcgtt cgcggtgacg
    13141 gcgcccgcga cgctgacgct gctcgaccgg gccgtgcgcg ggctggccga ccccgtggac
    13201 ccggtcgccc ggctggacgc cgccgcggtg ctgctgtccg cggtcgcgtt ccaggcgatc
    13261 tgggcacggg cctggtggcg caggcacggc ccgcgcgtac ggcgcgcgct gcgcacgcgg
    13321 ctggggcgtt gatcaggacc gcgcgtagga gccgctcgtc agctcctcga ccagtccggg
    13381 ccgtcgcggt gcccatccga acagccgccg cgcccgcgag gcgtccagcg gcgacgaacg
    13441 ggtgagcgtg gcggcgagcg gccccatcgc ggcggtcccc tgctccagcg tgagcgacac
    13501 ggcctgggcg ccggtcaggc cggcgaccgc ctcggccatc cgccggatcg gggtccgctc
    13561 ggccgaggcg gcgttgacga cgaccccggg ctcgcggcgc tccagcgcgg cgacgtacag
    13621 cgccgcgagg tcgtcgacgt gcaccgacga ccactcgttt gcgccgtcgc cgatgtaggg
    13681 caccatcccg ctctgccggc cggcgccgat gagcccctgg agcaggcccg acccgccgcg
    13741 cccgtagaca agcgccgccc ggatcaccgt gcccgccacg tggccggcgg ccaggacctg
    13801 ccgctcgccg agcaccttgt acggctgcgc cgacgtctcg ggggtgacgg ggtggtcctc
    13861 gtccacggtg gcgccctgcc ggtccgggta gaccaggccc gtgctggtgt agacgaacgc
    13921 gccgccgtcg tgcaggccgt ccagcagcgc cgcgagggcg tcgtgctcga tctcgcccat
    13981 gccaggatcg gcgtagtcca cggcggcgtg gaccacggcc tcggccgacg cggcggcgcc
    14041 gcgcaggacg tcgaggtccc gcaggctccc ggccaccgcc ttggcgccca gcccttcgac
    14101 ccgctcgcgg gcctcgtccg agcgggccag ggcgaccacc tcgtggtcgg ccctgacgag
    14161 gtgctcggcg acgactccgc cgacgtagcc gctggcgccg gtgatgagaa ttcgcatgat
    14221 cgtgtgcctc ccgtgaggtc ggtgaccgcg gcgtgtccgc gtccgccgcc ggtcggtgcc
    14281 aaccccaccg tcgcttccgg ccgtcccgca cagccaggga ccgagagtcc gtggctgagg
    14341 gggtccgcgc ggccgacgcc gggcgtacgg tcacaagcat ggacaagcat ggcctggcgc
    14401 ggttcctccg gagcaagcgg gagagcatcg accccgccga cgtcggcctg cccctgggac
    14461 gccgccgccg caccccgggc ctgcggcgcg aggaggtcgc ccagctcgcg tacgtctcgg
    14521 tggaccacta cacgcggctg gaacaggcgc ggggccgtca cccgtcgcgg cgggtgctcg
    14581 acggcatcgc ccgcgccctg cgtctgtcgg accaggagcg ggcccacctg ttccacctcg
    14641 ccggtgagct ggaggagagc cgatcagggg agccggtgag cgaggtgcgc ccgagcacgc
    14701 tgagcctggt caaccggctg accgacgccg ccgcgatcgt cgtggacgac acgtgccgcg
    14761 tgctggcctg gaacccgctg gcggcagccc tgttcgagga cttctcggcc ctggccggcc
    14821 aggagcgcaa cgtcatcagg cgctacttcc tgcatcccga cccggagcgg cggcactacg
    14881 ggatgagcag ccctgaacgg ttcgccgtca cggcggtcag ctatctgcgc gtcgccgcga
    14941 cccgctatcc ggacagccac gagctgaaca gcctgatcgc ggaactggtg gcggggagcg
    15001 aggacttcgc ccggctgtgg aactcgcagc ggttccacat cgagcgtcac ctgcaccaga
    15061 ccgtgcggca cccgcgcgtc gggccgatcg agctggactt cgacgtgctc acggtgcccg
    15121 accaggagca gcaggtggtc atcttcaccg ccgagccggg gtccacggcc tacgagtccc
    15181 tgcagttcct gaaggtcgtc ggcgccgagc ggacgcccgc cgacgcctga tccacgcccg
    15241 ccgacgtcca tctccccgcc cgtcggcggt tgatgtaaaa agttctgtac atcacgtcaa
    15301 agacggttta ccttgatggt gtcaaagatt ctgtacatcc agagagggga gccgatcatg
    15361 acgcacgagg agaagcgcgc ctggatccgg ctggtcgtcg ccgtggtcgc ctacgccgtg
    15421 tacgtcgtca ccatcctcag acgggcggac ggaggcccgc tatcagatgt gccgtacgcc
    15481 gccgccctgc tgtggacgat cggcggggcg atcggcgcgg cgatcctggc cgagatcggg
    15541 atggcgatcg tcaatccgcg ggcctcgcgc gtcatcgacg tccgcgacaa ggagatcggg
    15601 cggctcggcg actacaccgg tcaggcgttc gtggccatcg gggcgctcgc ggcgatgctc
    15661 atggccgtgg cggagtggga cgggttctgg atcgccaacg tgatctacct cttcttcgtc
    15721 ctgtcggcga tcctcagcga caccaccaag atcatcctct atcgcaggag cgtgccggag
    15781 tggtgaagcc cacccgagtg acgaaccgca tccgcgcact gcggttcgcc cacgacgaga
    15841 tgacccaggc cgaactcgcc gagcgcatcg gcgtgaccag gcagaccgtc atcgccatcg
    15901 agcagggccg atactcgccg tccctggaga tggccttccg gatcgcccgg gtgttcggcg
    15961 ccccgctcga cgacgtgttc cagtatcccg acctccccga ggagacgaaa tgaaagccat
    16021 cgtccaggac gcgtacggcc cggccgacgt gctcgaatta cgcgacgtcg accgcccctc
    16081 gatccgcggc gacgaggtgc tcgtcgaggt ccgcgcggcc gccgtggacc ccggcgtgtg
    16141 ggtcctcatg accggcacgc cgtacctcgc gcgcgccggg ttcgggctgc gccgccccaa
    16201 ggttcccgtc cggggccgcg acgtcgccgg ggtggtgacg gccgtcggcg ccggcgtcac
    16261 ccgcttcagg cccggtcagg aggtgtacgg cgcctgcccc aacggctcgc tcgccgagtt
    16321 cgcgagggcg ccgcaggccc gcctcgcgcc gaagccggcc aacctcacgt tcgaacaggc
    16381 cgccgcggtg ccggtctccg gcatgacggc gctgcaggcc gtacgcgacg tcgccggcgt
    16441 gcgcccgggg cagcgggtgc tggtgatcgg cgcgtcggga ggcgtggggt cgttcgccgt
    16501 gcagatcgcc aaggcgctcg gcgcgagcgt caccggcgtg tgcgcgacgg cgaaggcgga
    16561 cttcgtgcgg tcgctcgggg ccgacgacgt catcgactac acccgcgagg agatcgacca
    16621 cgacggcgcg cgctacgacg tcgtcgtcga caccgcgggc aaccggccgc tgtccctgct
    16681 gcggcgcgtc ctgaccccgc gcggcacgct ggcgatcgtc ggcggcgggc acacggcata
    16741 ccgcttcacc ggtggcatgg gacgcacgtt ccgggcgccg ctgctgtcgg ctttcacgcg
    16801 gcagcgactg cgcccgatgt tctcccgcga gcgcgccgac cacctggagg aactgacccg
    16861 gctcatcgag tccggcgccg tcattccggc cgtcgaccgc acctatcccc tcgccgccgc
    16921 gcccgacgcg atccggcacc tcatggaagg ccaccccgcc ggcaaggtcg tcgtcaccgt
    16981 gtgaccgccc tcaggacgtc aggggcatcc ggcgggcgcg gaccgtgcgg cgactgatcc
    17041 gccagccgtg gtcgtcacgc acgagcgtgt cctcgtaggt cacgctgccc gtggtcccgt
    17101 cggcgttgac cccgatgccc ttcgagatcg ctcgcgcccg gccgtccgcc gcctcggtga
    17161 cgacgatgtt ggtcacgtga tgggcgaccg ggttcccctc gcccagggcg agcgcggcgt
    17221 cgcgcagcgc cgcgagcccg acgatcaccc cgccgccgag atcaccgacg tcgtagacca
    17281 cgtcgggcac gaacacctcg cgcaggccgt cgaagtcgcc gctgtccgtg agatggccgt
    17341 gcaggttgat caggtccgtg atggccgtgc ggtcgtcggc agtcagggtc atcgtcctcc
    17401 gccgttccat ccaaatgggg agctccccgt ctaaggttgt caccgtaaac ggggaactcc
    17461 ccggatagca agagaagccc gatagcaaaa gaagggagtg cggatgacgt cgagtggtcc
    17521 cgagcccgcg ccgcccggcc gtacgcgcag ggcggacgcc tcgcgcaacg ccgcactgct
    17581 gctcgccgcc gcacgcgaac tcgtcgcgga gtcggggccg gaggtcgcgc tggacgaggt
    17641 ggcgcggcga gccggcgtcg gcaacgcgac cctgtatcgg cacttcccca cccgcgccga
    17701 cctgctcgtc gccgtgtacg cggacgaggt ggcggagttg tgccgcaggg gcgccgacct
    17761 gccgccgggc ctctccccgg ccgacgcgct cttctcctgg ctggacgcgt tcgtcgtgca
    17821 cgtcgcgacg aagcggccgc tcgcactcgc ggccacggaa ggtcccaccg gccgtcgtag
    17881 cgcgttgttc gaccagtggc acacctcgat ccacgccacc gcgtccgacc tgctgcggcg
    17941 ggcacaggac gccggtgccg tgcggcccgg actcaccgtg accgacctgc tggccctcgc
    18001 cggcggcgcg gcactcaccg gaaccgatgt ggcccacgcc cggcggctca ccgcgctcct
    18061 gcgccgcggc ctggaaaccg gcgactgagg gttcggctcc ttgggccaga acaggtctgg
    18121 cgaaaagtga tatcactttg ctagtgtcgt gctagacacc gaggagaaga catgacagat
    18181 ctgcagatcg ccgtcgacat gccggccccc cagacccacg agcggacggc gcgagcgacc
    18241 gccggatggc ccatgctgat cctggccctg gtgggcctgc tgatcccggt cgcgctgatc
    18301 cccatcggag ccgtcctcgc ggccgagggc agcgtgggcg cggggacggc actgatcgtc
    18361 gccgggacgc tgctcctcct ggcggccgtc gtcgtcctca ccgggctcac cgcggtcgcg
    18421 ccgggcgagg cgcgcgtgat ccagttgctc ggccgctacg tgggcacggt ccgcacgccc
    18481 ggcctccggt tcgtggctcc cttcacccag aagcgccggg tgtcgaccag gatccgcaac
    18541 cacgagaccg acatcaccaa ggtcaacgac gccgacggca acccgatcga gatggccgcc
    18601 gtggtggtgt ggcaggtcga ggacacggcg aaggccgtct tcgaggtcga cgacttcgtg
    18661 gagttcgtcg ccttccagac cgagaccgcg gtccggcaca tcgccggcag ctacccgtac
    18721 gacgggcacg acgacatgct gtccctgcgc cagaacgcgg acgagatcac cggccgcctg
    18781 tcggccgaga tccaggcccg ggtcgcctcc gccggggtca aggtcatcga gtcgcgcatc
    18841 acccgcctgg cgtacgctcc cgagatcgcg caggcgatgc tgcgccgcca gcaggcgggc
    18901 gcggtcgtcg cggcccggca gcggatcgtg gacggcgcgg tcggcatggt cgaggccgcc
    18961 ctggcccgcc tcgacgcgca caacgtgatc gaactcgacg aggagcgcaa ggccaccatg
    19021 gtcagcaacc tgctcgtcgt cctgtgcggc gaccgcgacg tgcagcccgt ggtgaacacc
    19081 ggctccctgt accactagac cgtggcaagc gaaagaaaga gcatcctgct gcgactggac
    19141 cccgcggtgc acgacgcgct ggcccgctgg gccggcgacg aactgcgcag caccaacgcg
    19201 cagatcgagt tcctgctgcg ccgggcgctg tcggaggcgg gacggctccc gggcaacgcc
    19261 gctcgcatcc cccggcgcgg ccggcccgcc aagaaggaga ccccggctcc ggaatccccc
    19321 gccgccggcc cacccgacga ctgagaggag ggcggtcccg tggacgtccc cggttccctg
    19381 acggcccagc tctatctcct ggcctacgac ccccgcaagg agcgggtggt gacgaactac
    19441 cgcctcccct acctgctgcg cgcggccgcg ctcaccgatc tgctgctcat gggccggatc
    19501 gccgacgacg acggcaaggt ccgcgtggtg tcgaaggacc ggctcggcga cccggtcctc
    19561 gacggcctgc tccaccagct cgcggagtcg gggccccgcc cgtggcggca ctggatcggc
    19621 aaggacggcc gggccaccgt ccgggcggtc cgggacgagc tggagatgcg ccgctgggtc
    19681 agggtggagc tgcgccagcc gttcctgatc ttcaacagga gcgccgtccg cgtacgcgac
    19741 acgcgggtgg tgaagcgcct cgcggcgcgg gtggccggcg ccctctccgg gccggtgtcc
    19801 cggatcggcg accgcgacgc ggccctcgtc gggctggccg ccgcggcgga tctcggcacg
    19861 gtgctcccgc gcgcgaaaca gcgggcgcac aagcggcgca tcgagcagct gacagaacgc
    19921 ggcggcccgg cggcggccgc cctgcgcaag gtcatccagc aggcccgcgg cgcgagcggc
    19981 ggctgagccc gcccgccggc cgcgcgggcc cggtcatcgc cggcaggtgc ggagcatgtt
    20041 gagcagggcc accttctcct tcttggtgac gaagagccgg tagtggcgct tcacggtgat
    20101 ccaggaggtc gcgtaacggc accagtaggc gcggcgcggc ggacgccagc tctgcgggcc
    20161 ctgacctccc ttggccatgt tgacggagtg gctcaccacg accagttccg gacgggtgag
    20221 gtcgttggcg aacgcgcgcc gcttcgcctg gctccaccgc ttggcgccgg agcgccaggc
    20281 gtacgccagg ggaacgacgt ggtcgacgtc ggtctgcttc acgctcttca gcaccttgcc
    20341 gtcgtacggg ctgtaccaga cgcccttcac ggcctggcag gcggcgttcc tgcgcactcc
    20401 ccggccctgg cgggcgagga ccacctcccg cgcgtcgcat gtccccttgt ggtgcgccca
    20461 tcgcggctgg aaccgctggt ggctgtaccc gcggatcgac agcggcttgg cgaccttcag
    20521 ctgatccagc atgcgacggg cccgcgatcc ggtgtcggcc gcggcctgcg gggcgagcac
    20581 gacggcggtg acggggagga gcagacagga gagcgcggcg acccggagcg tgcgatgcag
    20641 gtagatcatg gttacagcca taccaaaatt ccccacccag cgtgacgata cgcgtagatc
    20701 cgggtgacgg cccgcgggcg gtggcgctcg cggcgcccgc gggccatgcc tgccggccgg
    20761 cgtgccgatg tcgcgcgccg ccgcccgagg gtggccgcga ccagcaccgg gggtaatccg
    20821 gcacttgata cacgaacatt cttgggatct ccggcatctc acccggcatg agactgcgca
    20881 ttgccctcac ggcactgctg ctaaccgccg tgccgctgac cgtcgtgcct ttggccgtcg
    20941 tgcctttggc cgcacggccc gcagcggcgg ccacgcccgt cacgatcgcg tacgcgcagc
    21001 ggacgcaggc gtgggaactg gtgctgaccg acggacaggt ggtgcgggtg ccggaggcgc
    21061 tcgccgtggc gcccaaggac accgtcaacg caggcgcgca ggcgccgttc ctgatcagcg
    21121 gagacggccg gcattacttc tactaccgca ggtcggac
//
