LOCUS       NZ_JABBWV010000006     20888 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H11081 NODE_6, whole genome shotgun sequence.
ACCESSION   NZ_JABBWV010000006
VERSION     NZ_JABBWV010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H11081
  ORGANISM  Microbispora sp. H11081
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 405738)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 405738)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Anotibioctics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012999535.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:41:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,738
            CDSs (total)                      :: 6,662
            Genes (coding)                    :: 6,604
            CDSs (with protein)               :: 6,604
            Genes (RNA)                       :: 76
            rRNAs                             :: 5, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            partial rRNAs                     :: 1, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 58
            CDSs (without protein)            :: 58
            Pseudo Genes (ambiguous residues) :: 0 of 58
            Pseudo Genes (frameshifted)       :: 7 of 58
            Pseudo Genes (incomplete)         :: 54 of 58
            Pseudo Genes (internal stop)      :: 2 of 58
            Pseudo Genes (multiple problems)  :: 5 of 58
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:04:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 50527
            Orig. end                         :: 71415
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBWV010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20888
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20888
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20888
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10888](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10888
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    306..322
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            528..1181
                     /locus_tag="HHX31_RS17330"
     CDS             528..1181
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132572.1"
                     /locus_tag="HHX31_RS17330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD family hydrolase"
                     /protein_id="WP_169949340.1"
                     /sec_met_domain="HAD_2 (E-value: 1.9e-10, bitscore: 35.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRALVFDVGETLIDETRIWSRWADRLGVPRLTFMGVLGGMAALD
                     RGHREAFELVRPGIDLDAELDAWRREDPSGLRENFDADDLYPDVRPALTALRDLGYDLV
                     VAGNQPPQAYDALVAMDLPVDGIHTSAGWGLEKPDPAFFAKVAAVCGHDPGEILYVGDR
                     LDNDVLPAARAGMRTALLRRGPWGYLHAHRPDAARADLVADGLADLVRLVTVLG"
     gene            complement(1182..1634)
                     /locus_tag="HHX31_RS34400"
     CDS             complement(1182..1634)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024212.5"
                     /locus_tag="HHX31_RS34400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_211589860.1"
                     /transl_table=11
                     /translation="MVSSDLTLLFTALAAACDAEVRARMAAAGHDRVRTVHGYVFQHLL
                     TGPVRVSDLAGLLGMTPQGASKVAAEMERIGYVARRTDPGDQRARVIELTPYGRAAIDT
                     GRAAREAVTAGMLGVLDAPEEFLASLDRLAQETGALRELLARRLRP"
     misc_feature    complement(1604..1618)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.85"
                     /tool="antismash"
     gene            1699..2802
                     /locus_tag="HHX31_RS17340"
     CDS             1699..2802
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.5"
                     /locus_tag="HHX31_RS17340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_169949341.1"
                     /transl_table=11
                     /translation="MRCDPAFTPVADAFRETGGGGGGGAALAVCVGGRMVVDLWQGTAD
                     ADGVRPWERDTVVNVFSASKGVLATLAHLYVQRGLLDLDAPVARYWPGFATATTLADLL
                     SHRSGLPAVRRPLPPGSLFDWDAMTAALAAESPWWTPGERHGYHAVTFGWLVGEVLRRA
                     GGRPVRDLVRDELGVPDLWIGLPASEAGRAAYLGPPEAGPDDPPSPLADALSEPGSITV
                     AAFCNPAEQLTPGLANTARWRAAEIPASNGHATARALATLYDRLVSGAIVGPDVLDRAV
                     APRSEGRDEVLLAGTRFALGFMLPCEIRPYAPNPRAFGHSGSGGALAFADPDAGVALAY
                     TPSRLVVSASGPDARWESLVTALYACL"
     gene            complement(2851..3423)
                     /locus_tag="HHX31_RS17345"
     CDS             complement(2851..3423)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013936.5"
                     /locus_tag="HHX31_RS17345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_169949342.1"
                     /transl_table=11
                     /translation="MATDVISLIKEDHRDVESLFERLKAMPENRPALLAELAAKFVAHS
                     EGEEDEVYPVLAKRRPEEKEEVHHGAEEHHEAEEMISRLLETDPDGPEFDTLLRELVEA
                     VTHHVEEEENDILPALEKALPFEERVQLGKAFSKRKAEVLAAPLKPRSRTKDELAHQAK
                     ERGIEGASAMTKDELAAAVKRKKQERG"
     gene            complement(3490..4986)
                     /locus_tag="HHX31_RS33685"
     CDS             complement(3490..4986)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019334.5"
                     /locus_tag="HHX31_RS33685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protein kinase domain-containing protein"
                     /protein_id="WP_211589861.1"
                     /sec_met_domain="Pkinase (E-value: 4.2e-40, bitscore:
                     132.1, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.1e-06, bitscore: 23.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAPLEPHDPRTLGGFRISGRLGEGGQGVVYLGHAPDGAPVAVKV
                     LKTGLDPVVRARLARELDALRGVAPFCTARVITAVVDGREPYVVSEFVDGPSLQQRVNA
                     SGPLRGGELERLAVGTATALAAVHGAGIVHRDFKPGNVLLGPDGPRVVDFGIARQGESE
                     TITAGPVGTPAYLAPEQIAGHPATPASDVFAWGATIVFAATGRAAFGADNVAAVMHRIL
                     TAFPDLSALPPSLRALVGRCLAKDPAERPAARDLLLELLGTAPGPVPTGASAGGGPPAA
                     PAPPSGPSLAPVTPAGGSDAQTVPGGGRGRSRARVLAGAGAALAALGVTAALLVPRLST
                     LSAGPSPAPGGSSAGASAPARNTSPADPAPTEATVSPSGGGDGTYPTTASAATIPQAFA
                     GKWQGHIVPTAGLLTSEYDIEIELRRGEKSGKWKEPANSCDGTLRLTGGSGSTLTFRLE
                     EVRGCVPGDVVLTRKGGALAYRHTDDLGLIAYEGDLTRDS"
     gene            complement(5022..6347)
                     /locus_tag="HHX31_RS17355"
     CDS             complement(5022..6347)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012863.5"
                     /locus_tag="HHX31_RS17355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_169949343.1"
                     /transl_table=11
                     /translation="MARPAHRLTMAALALAVSGTTVALTSAPGHAHSPSAPAANRHPTS
                     SSAPEAAPEAASAGAHRKAAPRPGDQAPVRRRLVGSWTTSTYRVPAALGGQTVRMVVRA
                     SIGGGGTRLRLSNVFGAAPVTFANVHVGVQAYGPEILAGTNRPVTFRGRPSVKVAPGKA
                     VWSDPIPGRIAGGSAVVVSLHLPGTVHGVTGHERAYATTYLSEPGDHAAEESGEGFTYT
                     STQWYFLDRLSVEAGAATIGSVVAFGDSITDGAGQAVDANRRWTDYLRQRLAHQAPSRR
                     LGVLNAGIAGNRLLLPNVGPSGVSRFSRDALSQHGVRTVVVYEGINDISRGDYTSIKPI
                     VYGYKRLIREAHARKIKVLGATLTPFYGFGTWTPEREAIRQRLNTWIRTSGAFDGVLDF
                     DRAVRDPDFPEQLALSYDSGDHLHLSDAGRRALAEAVNLRLL"
     misc_feature    6677..6697
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.49"
                     /tool="antismash"
     misc_feature    complement(6698..6711)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.03"
                     /tool="antismash"
     gene            6715..7488
                     /locus_tag="HHX31_RS17360"
     CDS             6715..7488
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546454.1"
                     /locus_tag="HHX31_RS17360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_311931888.1"
                     /transl_table=11
                     /translation="MLQGAANVRDLGGLPTVDGGTTVPGRIARADNLQGLSEGDVELLV
                     GDLKLRHVVDLRSETEVRLEGPGPLTRLPEVGIHHHSLFAEGGRLTDVEADTIDDRTLP
                     WQGERDEKDLAELRVTGYYYGYLRDRPDSVVSALRVLARDDGLAVVHCAAGKDRTGVVC
                     ALALAAAGATREAIIEDYVATGERLEHILARLRASHTYRADLDGKPADAHLPRPEYMDQ
                     FLSTLDTRFGGALGWLHAHGWTDADTQALRGRLRD"
     gene            complement(7506..8621)
                     /locus_tag="HHX31_RS17365"
     CDS             complement(7506..8621)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017547221.1"
                     /locus_tag="HHX31_RS17365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_169949345.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 3.5e-27, bitscore:
                     90.0, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 7.8e-26,
                     bitscore: 85.0, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLSDSPGIRVGLAGFGPAGSFFHAPLIAATPGLRLTAVVTRDPA
                     RAERVRAEHPGADVVSTPQALWDRCDLVVIATPNRTHVPLAAEALKAGLPVVVDKPLAG
                     TAAEARDLVRLARDRGLMLTVFQNRRWDGDFLTVRRLLPELGEVHRFESRFERWRPVPK
                     GGWRESGGPEEIGGVLYDLGSHLVDQALRLFGPVSQVYAETDVRRAGVRGDDDAFIALT
                     HRNGTRSHLWMSAVAADLGPRFRVLGSRASYVKWGLGPQEERLRAGGRPDAADRSGAGW
                     GSEPSERWGTLGAAGDAVPVPTEQGAYQRFYEGVVACLRDGAAPPVEPDEAADTIAVIE
                     AAVRSAARGEVTALPALPAFPALPAFPARNG"
     gene            complement(8710..9615)
                     /locus_tag="HHX31_RS17370"
     CDS             complement(8710..9615)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132569.1"
                     /locus_tag="HHX31_RS17370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proteasome assembly chaperone family protein"
                     /protein_id="WP_169949346.1"
                     /transl_table=11
                     /translation="MSDPTDLYRLDGDLPELTGPVLLYHFEGFVDAGAAGRLALGHLLA
                     ELEHRIIATFDVDRLIDYRSRRPPMTFDTDHWSDYDTPELAVYLVKDVTGTPFLVMSGP
                     EPDREWELFTEAVGMLATRLNAGKLVTTHGIPMGVPHTRPLGLTAHATRPDLVHGQTSP
                     FGKVRVPGSLAALIEFRLGAKGHDALGYAIHVPHYLAQAEYPQAAVTALEAITRGTGLV
                     FPMDTLRDAADKTNAEIEEQIAASEELAGAIRGLEQQYDAFQSGAERESLLAEEARMPT
                     GDELAAQFEAFLAERDDREG"
     misc_feature    9937..9948
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.01"
                     /tool="antismash"
     gene            10001..10888
                     /locus_tag="HHX31_RS17375"
     CDS             10001..10888
                     /EC_number="4.2.3.170"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF042951.1"
                     /locus_tag="HHX31_RS17375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4-epi-cubebol synthase"
                     /protein_id="WP_169949347.1"
                     /sec_met_domain="T1TS (E-value: 8.3e-77, bitscore: 253.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPYVDEVNRDTLAWLAASGMISDDAEFERFQLAHYGWLGARTYP
                     YASRQLCQLATDWCVWLFAFDDAYCESDRRAAEIARALPQLYSVVEGHKDPVDDVFARA
                     LLDIRTRIAARATADQVDRWCAMTKDYLFAQVWEAANREDDVVPTIDDYIFMRRRTGAM
                     LTVFALVDVAAEVRLTVDEWRHPVVQEMTRHANDVVVWDNDLISYAKERGEENIRNNLV
                     SVLVGHTRCTVQEAMDRIGVMRDEAVAAMAALTPATQALGSPAVDAYVDGLKYWISGSV
                     DYSLTSSRYFGAWQ"
     gene            complement(10923..13031)
                     /locus_tag="HHX31_RS17380"
     CDS             complement(10923..13031)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541908.1"
                     /locus_tag="HHX31_RS17380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_169949348.1"
                     /transl_table=11
                     /translation="MATPAGWRQEGNLPVELTSFVGRTRLLATLRHKLQEYRLVTVTGI
                     GGVGKSRTALRLAHQVRRQFRDGVWYVDLARLQDPAMVYHTITAALGIADQSPREGSDT
                     LTEWLADRELLLILDTCEHLVDACARLTQDLLDTAPHLRILATSRRSLNAPGEYTVAVP
                     PLSVPGDRPSENPYTNEAVELFGTRASAVVPDFMVDETNVSAVAELCRRLDGIPLAIEL
                     AAVRLRTLSVEQILALLADRFSLLAGASRTALPRHQTLRAAIGWSHELCEPAERLLWAR
                     LSVFAGDFELDAARHVCAGEALPADAILDVIGGLVDKSVLLSFPTPAGQRYRLIDTLRQ
                     YGGEWLDKLGETPDLRRRHRDYYLQLAERSEDSWSGPRQVHWYTRMRQEHDNIRVALDY
                     CLSTPGEEQVGLKLLSALWFLWVACGLAREGAVYLERALKASPLPSKERCKALWVLAYI
                     RGAQGDMAGALAAAEQCSTDAVRVGDSGAVLLGTKMQGTAAMLQGDAKKAMALLGVAIE
                     FHRGGRELNPGLLPAIVELSMVLLAQGELAEAEALLTDCLQVCQERGELWLCSYAWYVN
                     SLVHRATGRRDEALVACKESLRIKRHFHDVLGIVLCVDNLATLSLEAGDPERTAVLLGA
                     AQANWRTFGLPQFGSPFFTTEHEQCVKECKKLIGDAAYEASYAIGARYSLGDLVEYALD
                     DLDDFHLD"
     misc_feature    13094..13109
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.38"
                     /tool="antismash"
     gene            13266..13400
                     /locus_tag="HHX31_RS35155"
     CDS             13266..13400
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS35155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_283244554.1"
                     /transl_table=11
                     /translation="MDLFEEGLPVLPDQTSDDTDLGWGEWRSDSDVAHLIEERPPHWG"
     gene            13616..13987
                     /locus_tag="HHX31_RS17385"
     CDS             13616..13987
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="HHX31_RS17385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_211589862.1"
                     /transl_table=11
                     /translation="MALRCLIVDDSDHFKEAARLLLEADGIAVVGTASTSAGALRRFRE
                     LRPDLVLVDIDLGEESGFDVVLRLCAEAGRHRPSIILISTYDEQDFAEMIASSPAVAFL
                     SKARLSGRAIGEIIRKANA"
     gene            complement(14034..14693)
                     /locus_tag="HHX31_RS17390"
     CDS             complement(14034..14693)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565937.1"
                     /locus_tag="HHX31_RS17390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_169949350.1"
                     /transl_table=11
                     /translation="MDKAPARVVLADDDVLLREGLASLLERSGFEVAGQAGNAPELITL
                     VRRCHPDLAIIDIRMPPRHATEGVEAARVIRAEFPEIGILLLSAHVEVDQAMELLATGH
                     RIGYLLKTRVTAVSEFVGTLRRIVDGGSVVDPSLVAELINARRRHDPLEHLTQREREVL
                     ALMAEGRSNAGIAHKLWITEGTVEKHVRSIMSRMRLPETEDDHRRVLAVLTFLDAR"
     gene            14864..16681
                     /locus_tag="HHX31_RS17395"
     CDS             14864..16681
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013736.5"
                     /locus_tag="HHX31_RS17395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4118 domain-containing protein"
                     /protein_id="WP_169949351.1"
                     /transl_table=11
                     /translation="MTRPPLLLGVVVGVACVTVETLLALLLARTASTSPLGLPYLLGIL
                     LVSYVWGLPLGVATALASGLAYDLFLVPPMYRITLFSSWSWIALLVFLVVALLVSGAAA
                     LLRTLLTESDERRREADVGAGTARLLLRAEHLRAALPVVARRLAQDLGLPSVAIEFGPA
                     GDDRRRTALPLSDEGARFGSLVVPADLPQATLCRLRERVVPSLEAALVAARGREAVACA
                     LAASRDELARVAEEQAALRRVATLVARAVSPTEIFNAVAREMGLIVNADHTAIERYEPD
                     RTVVLMSSWSASGVGSPPPVGARRRLHEEGLSALVLRSGQPGRIMVDERTAGELGRWAR
                     DEENGVAIGGPIVVEGRLWGVMIAFFRGLERQPEGVEERMRDFTELVVTAISNALTRDE
                     LAASRARVVAASDETRHRIERDLHDGAQQRLVSLGLQLRMAETAVPPELPELRRQLSRT
                     AEGLALVLEDLRELSRGIHPAILSKGGLGPALRMLARRSSVPVDLRVRVRERLPERVEV
                     AVYYIVSESLTNVAKHAHASLVHIEVDATRERAKVAIHDDGIGGADPGRGSGLIGLSDR
                     VQALDGTIEVVSPVGDGTTLTALIPVGSG"
     misc_feature    14969..14971
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16754..17593)
                     /locus_tag="HHX31_RS17400"
     CDS             complement(16754..17593)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="HHX31_RS17400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_169949352.1"
                     /transl_table=11
                     /translation="MCRLSHTPVGDPAGRARDPRDHNEIALPVEAAESVLEQLAAARIE
                     LDRTAERQRRFLADASHELLTPLAGLRTQLEEARLHPGDTDLAELVDHTLRDVDRLQAI
                     VSDLLVLAKAGTRPVHERRRADLAELVRTGVSSRAPRAPMLFRLVPGVVIHAVEHEIHR
                     LLGNLLDNAQRHARSRVLVEVLQVGAHAEISVSDDGDGIAEADRDRLFEPFSRLDESRC
                     RSRGGPGLGLAVAREIVRAHGGTIGVEDAPEGGARFVVRLPLAGPLPGGGRHPHARA"
     gene            complement(17990..18937)
                     /locus_tag="HHX31_RS17405"
     CDS             complement(17990..18937)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893289.1"
                     /locus_tag="HHX31_RS17405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_311931894.1"
                     /transl_table=11
                     /translation="MSANRPAPGLTGDVPTGGRAAPAAADAADPRGGGAEGRAPGYAPG
                     RTLPLRVEFVRQLRRRRTMAMFGVLLALPWVLVVAFQFGPAGRGQSSLRLSDLATAGGL
                     NFAAFALSVSANFLLVVAVALFCGDTVASEANWSSLRYLLAAPVPRDRLLRQKLVVALA
                     YSTAAVTVVPLMALLAGTLVFGWNDITVPGTGEVIPAADVLPKFLIVIGYALVSQLVVA
                     AVAFLLSVGTDSPLGAVGGAVGLVIVSSILQAVEALGSLREFLPTFWNTAWLDALAPEP
                     DYSGMVKGVVVSVTYSVILIALAFRRFRRRDVVS"
ORIGIN
        1 gaagtccgcg acgggcccga gcagggggga ggcggggaag ccgtcggccg cgagtcggac
       61 cgcgggggcc accaggtcgg ccagcggcag gcgggcgtag cgctcgtgca gcatgagcca
      121 cccgtcggcg cagccgggca ccgggaccga gcggatgtcg tacaggtggg gcatccggtc
      181 ggctccctcc gcgcgcaacc ggccggggtc tgcgccggag cccgcccgcc ccgaggcgtt
      241 gagcgcggtg acgcccccgg tggggctccc gtcgtggacg agggcgaaca ggtcgccgcc
      301 caggccgcac atgtgcgggg cggtgacggt cagtacggcg ttggcggcga tcgccgcgtc
      361 caccgcgttg ccgcccttgt cgagggcggc gacgcccgcc gccgaagcca gatgatctac
      421 ggtgcacacc atgccgttca aggcataccg agtctcgctc acgttcggcg atgttacggc
      481 acctcgtaga gtggctgccg taatcaggac acacagggag gatgttcatg gtccgggcgc
      541 tcgtgttcga cgtgggggag acgctcatcg acgagacccg gatctggtcc cggtgggccg
      601 accggctcgg cgtgccgcgc ctgaccttca tgggggtgct cggcggcatg gcggcgctcg
      661 accgcgggca tcgggaggcg ttcgagctgg tcaggccggg aatcgacctc gacgccgagc
      721 tggacgcgtg gcggcgcgag gacccctcgg ggctgcgcga gaacttcgac gccgacgacc
      781 tctaccccga cgtgcggccc gccctcacgg cgctgcggga cctcggctac gacctggtcg
      841 tggcgggcaa ccagccgccg caggcgtacg acgcgctggt cgccatggac ctgccggtcg
      901 acgggatcca cacctcggcg ggctggggac tggagaagcc cgaccccgcg ttcttcgcga
      961 aggtcgcggc cgtctgcggg cacgaccccg gggagattct gtacgtcggc gaccgcctcg
     1021 acaacgacgt cctgcccgcc gcgcgcgccg ggatgcggac cgccctgctg cgccgggggc
     1081 cgtgggggta tctccacgcg caccgtccgg acgccgcccg cgccgacctg gtcgccgacg
     1141 gcctcgccga cctcgtccgc ctggtcacgg tcctcggctg atcaggggcg cagccggcgg
     1201 gcgaggagtt cgcgcagcgc gccggtctcc tgtgcgaggc ggtcgagcga ggccaggaac
     1261 tcctcgggcg cgtcgaggac gccgagcatt ccggcggtca cggcctcgcg cgcggcgcgg
     1321 cccgtgtcga tcgcggccct gccgtacggc gtcaactcga tcacccgcgc ccgctggtcg
     1381 ccgggatcgg tccggcgtgc cacgtagccg atgcgttcca tctcggccgc gaccttggag
     1441 gcgccctgcg gggtcatgcc gagcagcccg gccaggtcgg agacccgtac ggggccggtg
     1501 agcaggtgct ggaacacgta gccgtgcacg gtgcgcaccc ggtcgtgccc ggcggcggcc
     1561 atccgggcgc gcacctcggc gtcgcacgcc gcggcgaggg ccgtgaacag gagggtcagg
     1621 tcgcttgaca ccacctccgg atgctccaat actcaaccaa ggttgcgcaa tctcggttga
     1681 acaatttgga gggtgcccat gaggtgtgat ccggccttca cgcccgtcgc cgacgccttc
     1741 cgggagaccg gcggcggcgg aggaggaggc gccgccctcg ccgtatgcgt gggagggcgc
     1801 atggtcgtgg acctctggca gggcacggcc gacgcggacg gcgtacggcc ctgggaacgg
     1861 gacacggtcg tcaacgtctt ctcggcgtcc aagggagtgc tggcgacact cgcgcacctg
     1921 tacgtccagc gcgggctgct cgaccttgac gccccggtgg cccgctattg gcccgggttc
     1981 gccaccgcca ccaccctcgc ggacctgctc tcgcaccgtt ccgggctgcc cgccgtccgc
     2041 cggccgctgc cgccgggctc cctgttcgac tgggacgcga tgacggccgc gctcgccgcc
     2101 gagagcccct ggtggacgcc gggggagcgg cacggctacc acgcggtgac cttcggctgg
     2161 ctggtcggcg aggtgctgcg ccgggccggc gggcggccgg tccgcgacct ggtccgcgac
     2221 gagctgggcg tccccgatct gtggatcggc ctgcccgcgt ccgaggcggg gcgtgccgcc
     2281 tacctcggcc cgcccgaggc cgggccggac gatccgccgt cgccgctggc ggacgccctg
     2341 tccgagcccg ggtcgatcac tgtggcggcc ttctgcaacc ccgcggagca gctcacgccc
     2401 ggcctggcca acaccgcgcg ctggcgggcc gccgagatcc ccgcgtccaa cgggcacgcc
     2461 accgccaggg ccctcgccac cctgtacgac cggctcgtgt ccggtgcgat cgtcggcccc
     2521 gacgtgctcg accgggccgt ggcgccccgg agcgaagggc gcgacgaggt actgctggcg
     2581 ggcacccgct tcgcgctcgg cttcatgctg ccctgcgaga tccggccgta cgcgccgaac
     2641 ccgcgcgcct tcgggcacag cggctcgggc ggggcgctcg ccttcgccga tccggacgcg
     2701 ggagtcgccc tggcctacac cccgagccgc ctcgtcgtca gcgcgtcagg tccggacgcg
     2761 agatgggaat ccctggtcac ggcgctgtac gcgtgtctgt gacggcccgc ggggcaccgg
     2821 gctgggccgc acgccgccgc gacggacgcg tcagccccgt tcctgcttct tccgcttgac
     2881 ggcggcggcg agctcgtcct tcgtcatcgc ggacgcgccc tcgatccccc gctccttggc
     2941 ctggtgcgcc agctcgtcct tggtccgcga ccgcggcttg agcggggcgg ccagcacctc
     3001 ggccttccgc ttgctgaagg ccttgccgag ctgaacccgc tcctcgaagg ggagggcctt
     3061 ctccagggcc gggaggatgt cgttctcctc ctcctcgacg tggtgcgtca ccgcctcgac
     3121 cagctcgcgc agaagcgtgt cgaactcggg gccgtcgggg tcggtctcca ggagccggga
     3181 gatcatctcc tcggcctcgt ggtgctcctc cgcgccgtgg tggacctctt ccttctcctc
     3241 gggccgccgc ttggcgagca cgggatagac ctcgtcctcc tcgccctcgc tgtgagcgac
     3301 gaacttcgcc gccagctccg cgagcagggc cggccggttc tccggcatcg ccttgagccg
     3361 ctcgaacagc gactccacgt cgcggtgatc ttccttgatc aggctgatga cgtcggttgc
     3421 cattggttcc tcctgtccct ggacgcgctg gcactacccg gcgccgcggc ggtcacaccg
     3481 atccggacac taggagtccc tggtgagatc cccctcgtag gcgatgagcc cgaggtcgtc
     3541 ggtgtgacgg taggcgaggg cgccgccctt gcgggtgagc acgacgtcgc cggggacgca
     3601 tccccgcacc tcctccaggc ggaacgtgag cgtggagccg gagccgccgg tcagccgcag
     3661 cgtgccatcg cacgagttcg ccggttcctt ccacttgccc gacttctcgc cgcgccgcag
     3721 ctcgatctcg atgtcgtact cgctggtgag gagcccggcg gtgggcacga tgtgaccctg
     3781 ccacttgccc gcgaacgcct gcgggatggt cgcggcggaa gcggtcgtgg ggtacgtccc
     3841 gtccccgccg ccggacgggg agaccgtggc ctcggtcggc gccgggtcgg ccggggacgt
     3901 gttccgcgcg ggcgcgctcg ccccggccga gcttcctcct ggagcgggcg acgggccggc
     3961 cgacaatgtg gacaggcgcg ggaccagcag tgccgccgtg accccgagtg ccgccagggc
     4021 cgcgcctgca ccggccagaa cccgggcgcg cgatctgccg cggccgcctc cgggaacggt
     4081 ctgcgcatcg ctcccgcccg ccggcgtcac cggcgcaagc gacggtccgg acggcggtgc
     4141 gggcgcggcg ggcgggccgc cgcccgcgct cgcacccgtg gggaccggcc ccggcgcggt
     4201 gccgagcagt tcgagcagca ggtcgcgggc ggccgggcgt tcggcggggt ccttggcgag
     4261 gcagcgtccg acgagcgcgc gcagggacgg cggcagcgcg ctcaggtcgg ggaaggccgt
     4321 caggatgcgg tgcatcacgg cggcgacgtt gtcggcgccg aacgccgccc ggcccgtcgc
     4381 ggcgaagacg atcgtcgccc cccacgcgaa cacgtcggag gcgggggtcg ccggatgccc
     4441 cgcgatctgc tcgggcgcca ggtaggccgg ggtgcccacc gggcccgcgg tgatcgtctc
     4501 gctctcgccc tggcgggcga tgccgaagtc gaccacacgg ggaccgtccg gccccagcag
     4561 cacgttgccc ggcttgaagt cgcggtgcac gatgcccgcg ccgtggaccg ccgccagcgc
     4621 ggtcgccgtg cccaccgcga gccgttccag ctcgcctccg cgcagcggcc ccgacgcgtt
     4681 cacccgctgc tggagcgagg gcccgtcgac gaactcgctc acgacgtacg gctcgcgccc
     4741 gtccacgacc gcggtgatca cccgggccgt gcagaagggg gcgacgccgc gcagcgcgtc
     4801 gagttcgcgg gccagccggg cccggacgac ggggtcgagc ccggtcttga gcaccttcac
     4861 cgcgaccggt gcgccgtcgg gcgcgtggcc caggtagacg acgccttggc cgccctcgcc
     4921 gagccgtccg ctgatacgga acccgccgag cgtacgcggg tcatgtggct caaggggggc
     4981 gaccatggtc acaccgtagc gacccggcgg ccggtccgag atcagagcag gcgcaggttc
     5041 accgcttcgg cgagcgcgcg ccgccccgcg tcgctcaggt gcaggtggtc gccggagtcg
     5101 tacgagaggg ccagttgctc cgggaagtcg gggtcgcgca cggcccggtc gaagtcgagc
     5161 acgccgtcga acgccccgct cgtgcggatc caggtgttga gccgttgcct gatcgcctcg
     5221 cgctcggggg tccaggtgcc gaagccgtag aacggggtga gcgtggcgcc cagcaccttg
     5281 atcttgcggg cgtgcgcctc gcggatcagc cgcttgtacc cgtacacgat cggcttgatc
     5341 gaggtgtagt cgccacggga gatgtcgttg atcccctcgt agacgacgac tgtgcgcacc
     5401 ccgtgctggg acagcgcgtc gcgggagaac cgggacacac cgctcgggcc gacgttgggc
     5461 agcagcagcc ggttcccggc gatcccggcg ttgagcaccc ccagccgccg cgacggcgcc
     5521 tggtgggcca gccgctgccg caggtagtcg gtccaccggc ggttggcgtc gacggcctgg
     5581 cccgcgccgt cggtgatcga gtcgccgaac gcgaccacgg agccgatcgt ggccgcgccc
     5641 gcctccacgg agaggcggtc gaggaagtac cactgcgtgc tggtgtaggt gaagccctcg
     5701 ccgctctcct ccgccgcgtg gtcgccgggc tcggacagat aggtggtggc gtaggcgcgt
     5761 tcgtggccgg tgacgccgtg gaccgtgccg ggcaggtgga ggctgacgac gacggcggag
     5821 ccgccggcga tccggcccgg gatcgggtcg ctccagacgg ccttgcccgg cgccaccttc
     5881 accgagggac gcccgcggaa ggtcaccggc cggttggtgc ccgcgaggat ctccgggccg
     5941 tacgcctgga cgcccacgtg gacgttcgcg aacgtcacag gcgcggcccc gaagacgttg
     6001 gacaggcgca gccgtgtgcc gccgccgccg atgctggcgc gcacgaccat ccgtacggtc
     6061 tgcccgccga gcgccgcggg gacgcggtag gtcgaggtgg tccacgagcc gaccaggcgc
     6121 cgccgtacgg gcgcctggtc gccgggccgc ggagcggctt tccggtgtgc gccggccgac
     6181 gcggcttccg gcgcggcttc cggcgcggag gaggacgtgg gatgccggtt ggcggccggg
     6241 gccgaggggg agtgcgcatg gccaggcgct gaggtgagcg ccacggtcgt gccgctgacg
     6301 gcgagggcga gagcggccat ggtcaaccgg tgagccggcc gtgccatccg ggtcctccat
     6361 gtggggtgtc gctggcctgg gggcgggtcc gcggcggtgg cgctcccgac cggcgcggcg
     6421 ggatccgttg atcgagagcg tccgcgacgc catacattac gctctttgcc gtcgacgggg
     6481 tgtgaaggtg accgtcaggg gtatgggtaa ccccattttg ggggaagccg tcccgcgatt
     6541 tgagaaaccc cacgcggccg cccgctctcc gggcctgccg ctcctcaacc gcggcgtacc
     6601 gaacacacga caccatcaat acgacagcgg gtgcatagct tcactccacg ctcagcttcc
     6661 cgtcatagag ggacagatag ggtcggcatg atgaatgcat acgagcgttg gatcgtgctt
     6721 cagggagcgg cgaacgtacg ggacctcggc ggtctgccga ccgtggacgg cgggaccacg
     6781 gtgcccggcc ggatcgcgcg ggccgacaac ctgcagggcc tcagcgaggg cgacgtcgaa
     6841 ctgctcgtgg gcgacctcaa actgcgccat gtggtcgacc tgcggtcgga gaccgaggtg
     6901 cgcctggagg ggcccggccc gctgacccgc ctgccggagg tcggcatcca ccaccacagc
     6961 ctgttcgcgg agggcgggcg cctcaccgac gtcgaggccg acaccatcga cgacaggacg
     7021 ctgccgtggc agggggagcg cgacgagaag gacctggccg agctccgcgt gacgggctac
     7081 tactacggct acctgcgcga ccggcccgac tccgtggtga gcgccctgcg cgtgctcgcc
     7141 cgtgacgacg gcctcgccgt ggtgcactgc gcggcgggca aggaccgcac cggcgtggtc
     7201 tgcgcgctgg cgctcgccgc ggcgggcgcc acccgcgagg cgatcatcga ggactacgtc
     7261 gccacgggcg agcgcctgga gcacatactc gcgcggctgc gggccagcca cacctaccgc
     7321 gccgacctcg acgggaagcc ggccgacgcc cacctgccgc ggcccgagta catggaccag
     7381 ttcctgtcga cgctggacac ccggttcggc ggcgccctcg gctggctgca cgcccacggc
     7441 tggaccgacg cggacaccca ggcactgcgc ggccggctgc gtgactgacc cgtacgaccg
     7501 gccggtcacc cgttccgcgc ggggaacgcg gggagcgcgg ggaacgcggg gagcgcgggg
     7561 agcgccgtca cctcgccgcg ggcggccgac cggacggcgg cctcgatgac ggcgatggtg
     7621 tcggccgcct cgtccggttc gaccgggggc gcggcgccgt cgcgcaggca ggccacgacg
     7681 ccctcgtaga accgctggta cgccccttgc tcggtgggga cggggacggc gtcgcccgcc
     7741 gccccgagcg tgccccagcg ctcggagggc tccgagcccc accccgcccc ggagcggtcg
     7801 gcggcgtccg ggcgtccgcc cgcgcgcagg cgctcctcct gcgggcccag cccccacttg
     7861 acgtacgacg cgcgggagcc gagcacccgg aacctcgggc cgaggtcggc ggcgaccgcg
     7921 ctcatccaca ggtgcgaccg ggtgccgttc cggtgggtca gcgcgatgaa ggcgtcgtcg
     7981 tcgccccgca cccccgcccg cctgacgtcg gtctccgcgt acacctgcga gaccgggccg
     8041 aacagccgca gcgcctggtc cacgaggtgg ctgccgagat cgtagaggac gccgccgatc
     8101 tcctcgggcc cgccggactc gcgccagccg cccttgggca ccggccgcca ccgctcgaac
     8161 cgtgactcga accggtggac ctcgcccagt tcgggcagca gccggcgcac cgtcaggaag
     8221 tcgccgtccc agcgcctgtt ctggaagacc gtcagcatca gcccgcggtc gcgcgcgagc
     8281 cgtacgaggt cgcgggcctc ggcggcggtg cccgccagcg gcttgtcgac gaccacggga
     8341 agaccggcct tgagcgcctc ggccgccagg ggcacgtggg tgcggttcgg ggtcgcgatc
     8401 accacgagat cgcagcggtc ccacagggcc tgcggggtgg acacgacgtc cgcacccgga
     8461 tgctcggcgc ggacgcgctc ggccctggcc gggtcgcggg tgacgacggc ggtgaggcgc
     8521 agccccggcg tggcggcgat caacggcgcg tggaagaagg atccggccgg accgaaaccg
     8581 gccagtccga cccggatgcc gggggagtcg gagagcgaca tggagggaga gtgatccctt
     8641 tcgtgcgagt tcgtgcgagt tgctccggcg gcgatcgggc aggacgccgc cgtcccggtc
     8701 tcccggcggt cagccttcgc ggtcgtcccg ctcggcgagg aacgcctcga actgggcggc
     8761 gagctcgtca cctgtgggca tccgcgcctc ctcggccagc aggctctccc gctcggcgcc
     8821 cgactggaac gcgtcgtact gctgctccag gccgcggatc gcgccggcca gctcctccga
     8881 cgccgcgatc tgctcctcga tctcggcgtt ggtcttgtcg gcggcgtctc tgagcgtgtc
     8941 catggggaac accagcccgg tgcctcgggt gatggcctcc agcgccgtca ccgcggcctg
     9001 cggatactcc gcctgggcga ggtagtgggg cacgtggatc gcgtagccga gcgcgtcgtg
     9061 gcccttggcc ccgagccgga actcgatgag cgcggcgagg ctccccggca cgcggacctt
     9121 gccgaacggg ctggtctgcc cgtggacgag gtcgggccgc gtggcgtggg ccgtcaggcc
     9181 gagcggccgg gtgtgcggga cgcccatcgg aatcccgtgc gtggtcacca gcttgccggc
     9241 gttgagccgg gtcgccagca tgccgacggc ctcggtgaac agctcccact cccggtcggg
     9301 ctccggcccg ctcatgacga ggaacggcgt gcccgtgacg tccttgacca ggtagacggc
     9361 cagctcagga gtgtcgtagt cactccagtg atcggtgtcg aaggtcatcg gcgggcggcg
     9421 cgaccggtag tcgatcagcc ggtccacgtc gaaggtcgcg atgatccggt gctccagttc
     9481 ggcgaggagg tgccccaggg ccagccgccc ggcggcaccg gcgtcgacga acccctcgaa
     9541 gtggtacagc agcaccggac cggtcagctc gggcaggtcc ccgtcgagcc gatagagatc
     9601 cgtggggtcg gacacgagtc ccagcctttc tcgcgaagtc tttacgtact gaacctacgg
     9661 gacccccggt cgattccgtg ctcgatgcag tgctcgatgt gctgctcgat gtcctgctcg
     9721 acaccgtgat cgaaacaggg ggcggttgcg gcgaccctac cggtggactg tggagagcgc
     9781 ggagccggac ccgggggccg gaggagttcg ccaccaggcc gttcgaactc gcgaggccga
     9841 accggccgag tcgctccggc tgactgatgt gtccgtaatt ggtggaggtc tggcgtcgtc
     9901 caaccggtag gaccatgctt gtcggatggc taatgcgaaa gcgcattccc ttagcgagcc
     9961 cctccgcctt ccctcactca cctgcccctt ccccagtgcg gtgaacccgt acgtcgacga
    10021 ggtgaaccgg gacacgctgg cctggctggc cgcctccggc atgatctccg acgacgccga
    10081 gttcgagcgt ttccagctcg cccactacgg atggctgggc gcccggacct acccgtacgc
    10141 ctcccgccag ctgtgccagc tcgccaccga ctggtgcgtg tggctgttcg cgttcgacga
    10201 cgcctactgc gagtccgacc ggcgggcggc ggagatcgcc cgcgccctgc cccagctcta
    10261 cagcgtggtc gaggggcaca aggacccggt cgacgacgtc ttcgcccggg cgctgctcga
    10321 catcaggacc aggatcgccg cccgcgccac cgccgaccag gtcgaccgct ggtgcgcgat
    10381 gaccaaggac tacctgttcg cacaggtgtg ggaggccgcc aaccgcgagg acgacgtggt
    10441 gcccacgatc gacgactaca tcttcatgcg ccgcaggacc ggcgcgatgc tcaccgtctt
    10501 cgcgttggtc gacgtggccg ccgaagtgcg cctcaccgtg gacgaatggc gccacccggt
    10561 cgtgcaggag atgaccaggc acgccaacga cgtcgtcgtc tgggacaacg acctcatctc
    10621 gtacgccaag gagcgagggg aggagaacat ccgcaacaac ctcgtcagcg tgctcgtcgg
    10681 gcacacgcgc tgcacggtcc aggaggcgat ggaccggatc ggcgtgatgc gcgacgaggc
    10741 ggtggccgcg atggcggcgc tcaccccggc cacccaggcg ctcggctcgc ccgcggtcga
    10801 cgcgtacgtc gacggcctga agtattggat cagcggcagc gtggactact cgctgaccag
    10861 ttcgcggtac ttcggcgcgt ggcagtgacg actatcggag accctcggga cgcggcgtcc
    10921 ggtcagtcca ggtggaagtc gtcgaggtcg tccagcgcgt actcgacgag gtcgcccagg
    10981 ctgtaccggg cgccgatggc gtacgacgcc tcgtaggcgg cgtcgccgat cagcttcttg
    11041 cactccttga cgcactgctc gtgctcggtg gtgaagaacg gcgacccgaa ctgcggcagc
    11101 ccgaaggtcc gccagttggc ctgcgccgcc ccgagaagga ccgcggtccg ctccgggtca
    11161 ccggcctcca ggctgagcgt ggcgaggttg tccacgcaca ggacgatgcc gagcacgtcg
    11221 tggaagtgcc gtttgatacg cagcgactcc ttgcacgcca ccagcgcctc gtcacgccgg
    11281 ccggtggccc ggtggacgag ggagttgacg taccaggcgt aggagcacag ccacagctcg
    11341 ccgcgttcct ggcagacctg caggcagtcc gtcagcagcg cctccgcctc cgcgagctcg
    11401 ccctgcgcga gcagcaccat ggacagctcg acgatcgccg gcagcaggcc cgggttcagc
    11461 tcccgcccgc cgcggtggaa ctcgatcgcg acgccgagca gcgccatggc cttcttcgcg
    11521 tcaccctgca gcatggccgc ggtgccctgc atcttggtcc cgagcagcac cgcgcccgag
    11581 tcgcccacgc gtacggcgtc ggtgctgcac tgctcggcgg cggcgagcgc gcccgccatg
    11641 tcgccctggg cgccgcggat gtaggccagc acccacaggg ccttgcagcg ctccttgctc
    11701 ggcagggggc tggccttgag cgcacgctcc aggtagaccg cgccctcgcg ggcgagaccg
    11761 cacgcgaccc acaggaacca cagggccgac agcagcttca ggccgacctg ctcctccccg
    11821 ggggtcgaca ggcagtagtc gagcgcgacg cggatgttgt cgtgctcctg gcgcatccgg
    11881 gtgtaccagt gcacctgacg cggccccgac caggagtcct cgctgcgctc ggccagctgg
    11941 aggtagtagt cgcggtgccg gcgccgcagg tccggcgtct cgccgagctt gtccagccac
    12001 tcgccgccgt actgccgcag cgtgtcgatc agccggtagc gctggcccgc gggcgtgggg
    12061 aagctcagca ggaccgactt gtcgaccagg ccgccgatca cgtcgaggat cgcgtcggcg
    12121 ggcagggcct cgcccgcgca gacgtgccgg gccgcgtcca gctcgaagtc gccggcgaac
    12181 accgacagcc gcgcccacag cagccgctcg gccggctcgc acagctcgtg gctccacccg
    12241 atcgccgcgc ggagcgtctg gtgccgcggc agcgccgtac ggctggctcc ggcgagcagg
    12301 ctgaaccggt cggcgagcag ggcgaggatc tgctcgaccg acagcgtgcg caggcgcacg
    12361 gcggccagtt ctatggccag ggggatcccg tcgaggcggc ggcacagctc ggcgacggcg
    12421 gagacgttgg tctcgtccac catgaagtcg gggacgacgg cggaggcccg ggtgccgaac
    12481 agctcgacgg cctcgttggt gtacgggttc tccgaaggcc tgtcgcccgg caccgacagc
    12541 ggcggcacgg ccaccgtgta ctcgcccggc gcgttgagcg accgccggct cgtcgcgagg
    12601 atgcgcaggt ggggcgccgt gtcgagcagg tcctgggtga gccgggcgca cgcgtcgacc
    12661 aggtgctcgc aggtgtccag gatgagcagg agctcacggt cggcgagcca ctcggtgagc
    12721 gtgtcggagc cctcacgcgg cgactggtcg gcgatgccga gcgccgccgt gatcgtgtgg
    12781 tagaccatcg ccgggtcctg cagccgggcc aggtcgacgt accagacgcc gtcccggaac
    12841 tgccgccgca cctggtgcgc gagacgcagc gcggtgcggg acttgcccac cccgccgatg
    12901 cccgtgacgg tgaccaggcg gtactcctgc agcttgtgcc tgagcgtcgc gagcagtcgc
    12961 gtccgcccga cgaagctggt cagctccacg ggcaggttgc cctcttgccg ccatcctgct
    13021 ggcgttgcca tgccgcctca cggggggttc gtccggcgtg ctccctgctc ccgcatcgta
    13081 cctttgggtg cggttggctg tctggtggta cgcacgtgac ctttgccccg ccgcgagacg
    13141 ggcgaatctc ccctcgcggg aaggtcgtcg acgccccgtc gcaggtccgg cgcgtccgcg
    13201 cgcggcttgg ggatgccggt aacattggcc gcgtgagtat gcggcatccg gatgacatgc
    13261 gtccggtgga cctcttcgaa gaggggctgc cggtgctgcc cgaccagacg agcgacgaca
    13321 ccgatctcgg gtggggcgag tggcgctccg actccgatgt cgcccacctg atcgaggaac
    13381 gcccccctca ctggggctag ggcggcgccg ccggctcgaa ccaggcggcc ttggctgtcc
    13441 gcggggtcac gctgcctggg tgcggcacgg ccgatgcggg aggagactgc ggccgtcggg
    13501 cagcagcggc ccgccgtctg ctccggaagc ccccatcatg cgggcatgtc cgcacgaccc
    13561 cgggatggcg gttaactgca atgacccgga cgtgctgcga tgccatcctg aagacgtggc
    13621 cctgcgatgc ctcatcgtcg atgacagcga tcacttcaag gaggccgccc gtctgttgct
    13681 ggaggcggac ggcatcgctg tcgtgggcac ggcgtccacc tcggccgggg ctctccggcg
    13741 cttccgggag ctgcggccgg atctcgtgct ggtcgacatc gacctcggcg aggagagcgg
    13801 cttcgacgtg gtcctgcggc tctgcgcgga ggcggggcgc caccggccga gcatcatcct
    13861 gatctcgacc tacgacgagc aggacttcgc cgagatgatc gcgagcagcc cggccgtcgc
    13921 cttcctgtcc aaggcccgcc tgtcgggccg cgccatcggc gagatcatcc ggaaggcgaa
    13981 cgcctgaccg gaccgcacgg atccgggccg cgtcctccct gtcgtgggcg gcgtcagcgg
    14041 gcgtcgagga acgtgagcac cgcgagcacg cggcggtggt cgtcttccgt ctccggcagc
    14101 cgcatcctcg acatgatgct gcgcacgtgc ttttccaccg tgccctccgt gatccatagc
    14161 ttgtgcgcga ttcccgcgtt cgagcgaccc tccgccatga gggcgagcac ctcgcgctca
    14221 cgctgggtga ggtgctccag cggatcgtgc cggcggcggg cgttgatcag ttccgccacg
    14281 aggctggggt cgacgaccga accgccgtcg acgatgcgtc tcagcgtccc gacgaactcg
    14341 gacaccgcgg tcacccgggt cttgagcaga tagccgatcc gatggcccgt ggcgagcaac
    14401 tccatcgcct gatcgacctc gacgtgcgcc gacagcagca ggatgccgat ctcggggaac
    14461 tccgcgcgga tgaccctggc cgcctcgacg ccctccgtgg cgtgtcgcgg aggcatccgg
    14521 atgtcgatga tcgcgaggtc ggggtggcac cgccgtacga gggtgatcag ctcgggcgcg
    14581 tttcccgcct ggccggcgac ctcgaacccc gatcgctcca acaggctcgc cagcccctcc
    14641 cgcaacagga cgtcgtcgtc cgccaggacc actcgtgccg gggccttgtc caccgttccg
    14701 ccgcctttcg cgcgcggtca ctgcccgcgt tcgcaggggc cgtacctcga tcgtgtcggt
    14761 gatcgggcag tcacacgatg cgcggccgat cagcgtcgat gtggtacata tggccgcgta
    14821 acgttgggtt atgcgcgcgc gatgggtgtc gtcgctgctt cgtatgacac gtccgcccct
    14881 tctgctgggc gtcgtcgtcg gcgtcgcatg cgtgacggtg gagacgcttc tggccctcct
    14941 actggcccgg acggcctcca cgagtccctt aggcctaccc tatctgctcg gaattctcct
    15001 ggtctcgtac gtgtggggcc tgccgctcgg cgtcgcgacc gcgctggcga gcggtctggc
    15061 ctacgacctc ttcctggtcc ccccgatgta ccggatcacg ctcttcagca gctggtcgtg
    15121 gattgcgctg ctggtcttcc tggtggtcgc gctgctggtc agcggtgccg cggcgctgct
    15181 gcgaacactg ctcacggagt ccgacgagcg ccgccgcgag gccgacgtcg gcgccggcac
    15241 ggcccgtctc ctcctgcgtg ccgagcatct gcgcgcggcg ctgccggtcg tggcccggcg
    15301 tctggcgcag gacctcggtc tgccgtccgt ggcgatcgag ttcgggccgg ccggcgacga
    15361 ccggcgccgc accgcattgc ccctcagcga cgagggcgcc cggttcggct cgctcgtcgt
    15421 gcccgcggac ctgccgcagg cgacgctgtg ccgcctgcgg gagcgcgtgg tgccttcgct
    15481 ggaggcggcg ctggtggcgg cgcgtggtcg tgaggccgtc gcctgtgccc tggcggcgag
    15541 cagggacgag ctcgccagag tggccgagga gcaggccgcc ctgcgcaggg tggcgacact
    15601 ggtcgcgcgc gcggtcagcc caacagagat cttcaacgcg gtcgcccgtg agatgggtct
    15661 gatcgtgaac gcggaccaca cggcgatcga acgatacgag cccgaccgta cggtcgtcct
    15721 gatgagctcc tggagcgcgt cgggcgtcgg gtccccgccg ccggtgggcg cgcgccggcg
    15781 gcttcacgag gagggcctgt ccgccctcgt cctgcgatcg ggacagccgg gcaggatcat
    15841 ggtggacgaa aggacggccg gggagctggg caggtgggcc agagacgagg agaacggggt
    15901 cgcgatcggt ggccccatcg tcgtcgaggg acgcctgtgg ggcgtgatga tcgcgttctt
    15961 ccggggcctg gagcggcaac cggagggtgt ggaggagcgc atgcgcgact tcaccgaact
    16021 cgtcgtcacg gctatctcca acgccctgac ccgcgacgag ctcgccgcct cacgcgcccg
    16081 tgtggtcgcg gcctcggacg agacccggca ccggatcgag cgcgacctgc acgacggggc
    16141 gcagcagcgc ctcgtctccc tggggttgca gctgcgcatg gcggagaccg ccgtgccgcc
    16201 ggagctgccg gagctcaggc gacagctgtc ccgcacggcc gagggcctgg cgttggtgct
    16261 ggaggacctg cgggagctgt cgcgcggcat ccacccggcg attctgtcca aaggcgggct
    16321 cggaccggcc ctgagaatgc tcgcgcgccg ctcgtcggtc cccgtcgacc tgcgggtgcg
    16381 agtccgggaa cgcctcccgg agcgggtcga ggtggccgtc tactacatcg tctcggagtc
    16441 gctgacgaac gtggccaagc acgcgcacgc ctcgctggtg cacatcgagg tggacgcgac
    16501 acgcgaaagg gcgaaagtcg cgatccacga cgacgggata ggcggcgcgg acccgggcag
    16561 ggggtccggg cttatcggtc tcagcgaccg tgtccaggcg ctcgacggga cgatcgaggt
    16621 cgtcagcccg gtcggcgacg gcaccacgct gacggccctc atcccggtcg gcagcggctg
    16681 acgaccgaac gggtcgcgcc gtggcctggc acggtcgcgg cccgcggaga catggtcacg
    16741 agccggcgta cggtcacgcc cgcgcgtgtg ggtgacgccc gccgccgggc agggggccgg
    16801 cgagcggcag gcggacgacg aatcgggcgc cgccctccgg cgcgtcctcc acaccgatgg
    16861 tcccgccgtg ggcccgcacg atctcgcgcg cgacggcgag gccgaggccg ggaccgcccc
    16921 ggctgcggca gcgggactcg tccagccggc tgaacggctc gaagagcctg tcccgatcgg
    16981 cttcggcgat gccgtctccg tcgtcggaca ccgagatctc cgcgtgcgcg cccacctgga
    17041 gcacctccac cagcaccctg cttctggcgt gacgctgcgc gttgtccaga agattgccca
    17101 gcaggcggtg gatctcgtgc tcgacggcgt ggatcaccac cccggggacg agccggaaca
    17161 gcatcggcgc ccggggcgcc cggctggaga cccccgtgcg gaccagctcc gccaggtcgg
    17221 cgcgtcttct ttcgtggacc ggcctcgttc ccgccttcgc gagcaccagc aggtcgctga
    17281 cgatcgcctg aaggcggtcc acgtctcgca gtgtgtggtc gacgagttcg gcgagatccg
    17341 tgtcgccggg gtgcagccgg gcttcctcga gctgcgtccg cagcccggcg agaggcgtga
    17401 gcagctcgtg ggacgcgtcg gccaggaaac ggcgctgccg ttcggccgtc cggtccagct
    17461 ctatcctggc ggcggcgagt tgttccagca cgctctcggc ggcctccacc gggagggcga
    17521 tctcgttgtg gtcgcgcggg tcgcgggcac ggccggcggg atcgccgacg ggtgtgtggg
    17581 agagccggca catgacgctc atggcagcgg tgccggctcg gccgcgaccg cttccgggcg
    17641 atgtcggcag ggatggggcg gccacgccgc gagcgggccc ggcggaaccc ggcacggcgc
    17701 ggttcccgcc ggttccacga cagttctcgg caatctgctc acctccggct gcgagaccgc
    17761 tgccgaggca gcggcgcttg agtacgtccg tcagggtggg cggtgcggcg acctcgttca
    17821 ccggccggac ggcgggcgtg tgcgcgccgg gccgggtgtg gtcggctccg tcaaccacaa
    17881 tgactcagcc gggctgggcc tgtctgccgt ggcaaccccc atcattcccc gctgccaccc
    17941 gtccccgggc atggcggcta gctgcaatgt ccgggggagg cgatgcccgt caggacacga
    18001 cgtcccggcg ccggaagcgg cggaaggcca gggcgatgag gatgaccgag tacgtcaccg
    18061 acaccaccac tcccttcacc atgccgctgt agtcgggctc gggcgcgagc gcgtcgagcc
    18121 acgcggtgtt ccagaaggtg ggcaggaact cgcgcagcga gccaagcgcc tcgaccgcct
    18181 gcaggatgct gctgacgatc accaggccga ccgccccgcc gaccgcgccg agcggggagt
    18241 cggtgccgac cgacagcagg aaggcgaccg cggcgaccac caactggctg accagggcgt
    18301 acccgatcac gatgaggaac ttgggcagca cgtcggcggc ggggatcacc tcgcccgtcc
    18361 ccggcacggt gatgtcgttc catccgaaga ccagcgtgcc ggcgagcagg gccatcagcg
    18421 ggaccacggt cacggcggcc gtcgagtagg ccagcgccac caccagcttc tggcgcagca
    18481 gccggtcgcg gggcaccggc gccgcgagca ggtagcgcag cgacgaccag ttggcctcgc
    18541 tcgccaccgt gtcaccgcag aacagggcca cggcgacgac cagcaggaag ttggccgaca
    18601 ccgacagcgc gaacgccgcg aagttgagcc cgcccgccgt ggcgaggtcc gacagccgca
    18661 ggctgctctg cccccggccg gccggcccga actggaacgc caccaccagc acccacggca
    18721 gggcgagcag cacgccgaac atcgccatgg tcctgcgccg ccgcaactgc cgtacgaact
    18781 ccacccgcag cggcagtgtg cgccccggcg cgtacccggg cgcccggccc tccgcgccgc
    18841 ccccgcgcgg gtccgctgcg tccgcggcgg cgggagcggc ccgcccgccg gtggggacgt
    18901 ccccggtcag gcccggggcg ggtcggttcg cgctcaacgc ttctctccga tcaggtcgag
    18961 gaacacgtcc tccaggcggg gcccgccgcc gttgacggcc gtcgcggtgc cgagcaggtc
    19021 gccgaccggc ccggccgaca ccagccgccc gcggtgcatg acgacgacgt ggctgcaggt
    19081 ctgctcgacc tcggcgagca ggtggctgga gacgatgacg gtgcgtcccc gctcggcgta
    19141 cgccctgagc acccggcgca tctcggcgat ctgcggcggg tcgaggccgt tcgtcggctc
    19201 gtcgagcacg agcaggtcgg gcaggccgag catggcctgc gcgatggcca ggcgctggcg
    19261 catgccctgg gagtaggtgc gcaccgcgcg ctccagggcc gcgcccagcc cggcgatctc
    19321 cagcgcctcc tccaggtggg cgtcctgcgg cggccgtccc gtcgcctgcc agtacagctc
    19381 caggttggcc cgcccggaca ggtgcggcag gaacccgggc ccctcgacga acgagcccag
    19441 ccgcgacagc accggtgcgc ccgggcgcac ccggtggccg aagatccgga tctcgccctc
    19501 gtcggggtgg atgaggccca tgagcatccg catggtggtg gtcttgcccg cgccgttcgg
    19561 cccgagcagg ccgagcacct ggcccttctc gacccggaac gacaggtcgt cgaccgcctt
    19621 ctcgccgttg cggtagcgct tgcccagccc gctgatgacc aaaggcacct cggccgacgc
    19681 ggcgtccggg gcgtcgctct cctcggggcg gcgcccggcc cggccggtca gcaggagcac
    19741 cgcggcgacc aggatcgcgg cgagcggcat ggcccacgtc caccacgcgg ggccggtggc
    19801 gggcgtccgc agcgccgcgt cccccggcag ttccagcgtg ggggactcca gcgcgacctg
    19861 gtagaccgcg ggggcggcgg gagtcgcgta cccgaggtcg gtggtggaca ccaccagccg
    19921 catcctgtgg cccgcgtcga agcgcctgtc gatggcaggg agcgccacgg tgaccggcgt
    19981 gcccgcctcg ctggcggtga cccgcagcgg cgcgaccagg ctcgagggga gcacgggcag
    20041 cgaccctccg gagacgtcgt agagcttggc gaacagcgtg gcctcacccg tgccgtagac
    20101 cctgatggtg acggccgggc tgccggtgac ctgcgtgggc ctggccagcg gggcggactc
    20161 gaagacggcc gcctggccgg gcatgtccag cgcgatcgac acgccgccgg cgccgccgag
    20221 cagcccgccg aggccgggca ccgccgagat cgacgcaggc gacccgcccg ccgggttggc
    20281 gatcgactgc cgggggcctt cgagggcgac ggtcgtccgc tcctcgcccg tcagacccgg
    20341 gtagcggtcc ccgatcgcgt gcagcagcac gggccggcgc gtgccggggt cgcgcccgcc
    20401 gtccctggtc acggtgaacg cggcggagcc gccgtcgccc gtcgcggggc ccgccccctt
    20461 gaggtagcgg tcgaaccagc cggtcgtgcg gtccgacagc cagtcggcct cgccgtcgcc
    20521 gccgtcgtgg ccgccgttga accaggcgac ctccacggga gcgccggtgg cggcgatggc
    20581 gcgggcgttg gcgtcggcgt gcgagagcgg gaacagcgag tcgcgctggc cctggagcag
    20641 cagcgtcggc accctgatcc tgccgggcac cgagaccggg ctcgacttgc gcaggaggtc
    20701 gatcgcctcc tgggtggccc ggccggtctc ggccacctcc tggtacatct cacagatctg
    20761 cggcaggaac cgcccgcacc gcacctgctc ggccccgggc gtcgccccgg cgccctgccc
    20821 tgagccctgt cctgagccct gtccagaccc ctgcccagtc tcgccgccgg gccgcgcccc
    20881 ggccgctc
//
