LOCUS       NZ_JABBWV010000003     24833 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H11081 NODE_3, whole genome shotgun sequence.
ACCESSION   NZ_JABBWV010000003
VERSION     NZ_JABBWV010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H11081
  ORGANISM  Microbispora sp. H11081
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 601605)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 601605)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Anotibioctics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012999535.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:41:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,738
            CDSs (total)                      :: 6,662
            Genes (coding)                    :: 6,604
            CDSs (with protein)               :: 6,604
            Genes (RNA)                       :: 76
            rRNAs                             :: 5, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            partial rRNAs                     :: 1, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 58
            CDSs (without protein)            :: 58
            Pseudo Genes (ambiguous residues) :: 0 of 58
            Pseudo Genes (frameshifted)       :: 7 of 58
            Pseudo Genes (incomplete)         :: 54 of 58
            Pseudo Genes (internal stop)      :: 2 of 58
            Pseudo Genes (multiple problems)  :: 5 of 58
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:04:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 490354
            Orig. end                         :: 515187
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBWV010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24833
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24833
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24833
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14833](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14833
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(16..642)
                     /locus_tag="HHX31_RS11855"
     CDS             complement(16..642)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017496.5"
                     /locus_tag="HHX31_RS11855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_169948104.1"
                     /transl_table=11
                     /translation="MAALPDDSWLLSIRPQPTRVTAEEYDALPEEIAKAIEIVDGYVAH
                     CAAPTPDQRIAGRRLANLLERHARAAMSKGHECLTVNNDVDLRLRDLPLLNRRPDVALY
                     RCLNREQGERLRAEHALLVVEIVSPGSETQDTTDKLGEYAKAGIPHYWIVRLDRTGVSA
                     IERYRLDRASMLYKHIGTLMKDEPGEAPVVSNPIPITVDWAELQF"
     misc_feature    complement(825..840)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(867..881)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.13"
                     /tool="antismash"
     misc_feature    870..886
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.8"
                     /tool="antismash"
     gene            1054..2574
                     /locus_tag="HHX31_RS33595"
     CDS             1054..2574
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544148.1"
                     /locus_tag="HHX31_RS33595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine protease"
                     /protein_id="WP_211589575.1"
                     /transl_table=11
                     /translation="MKRILALGGVAAGLLAAAAVAAPAQADTDVAPPVNLANTNFAAQQ
                     VAAFWYGQAKANLINATPYNVETTVPSRHVSTGGASADSKAGVVGSSGDQKAATSNLKN
                     VNLPKTTGKVFFIGADNKPHWCSATSVQSQYKNLVATAGHCVYDTVSNKATLDKWVFIP
                     GYYQGKTPWGIYVGKTAYTHYDYDVYEDGDRDYAFVTVYNGVQVTDVSADKVKNWVKNR
                     TFDTRAEAEKAKKDLELKTTGWTGEIVPVHTSKLAKAGDKEVERRYTPIVANQAKEALG
                     IRSKEEAEALARGATSEWVSEYKTSGITITRVSRAEFGPGDADHWSEDEMFFYFQKNNG
                     FYKASIWVLFDVDFKLKGHLVDIALKDVGTLGGNVGGQGLAYNQKVGTAVFVFGYPSGS
                     HPDGNYAFSGKTLKWAYGKTFKAAAPALKAEELVGVKSSFTGEGSIGSSWLYRYSNTKR
                     LGYLNGVTIAVSDTDGNKRIDTSVSPYFDGETLAVYQYAAKFASGKIV"
     gene            complement(2653..3780)
                     /locus_tag="HHX31_RS11865"
     CDS             complement(2653..3780)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542106.1"
                     /locus_tag="HHX31_RS11865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiolase C-terminal domain-containing protein"
                     /protein_id="WP_169948106.1"
                     /transl_table=11
                     /translation="MNIVIAGAAETDELGKLPHMSTAQLHLQAARNALADAGMTKDDID
                     GVATVGVPGPIQIAHALGIAPAWLDGTGVGGSSFLFHVRHAAAAIRAGLCTTVLITHGE
                     SGRSRVGAPRPALGPDSLIGQFEMPYGVLGPPTMFTLTALRYMKETGLTHEQLAEVAVA
                     QRRWAHRNPRAMFQDLITVEDVLASRMVAYPFHLLECCLVTDGGGALIVTSEERARRSP
                     VHLLGSGESAESPIISQMEDFTTSAAFRRSGEAAFAEAGIAHDDVDHLMIYDAFAHVPI
                     YGLEDLGFVKRGEAGPFIAEGHTSPGGRLPLNTNGGGLSYTHTGMYGMFAIQESVRQLR
                     GEAAAQVPDVEISVVLGNGGMFASAATLVLSNHRP"
     gene            complement(3777..4199)
                     /locus_tag="HHX31_RS11870"
     CDS             complement(3777..4199)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542105.1"
                     /locus_tag="HHX31_RS11870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Zn-ribbon domain-containing OB-fold protein"
                     /protein_id="WP_169948108.1"
                     /transl_table=11
                     /translation="MTASPKPVPKPTPETQPFWDGTAEGVLRIQRCRACARHYFYPRPA
                     CPRCGSDDVAWVTASGRATLYSYVINHRPAPGFEQDGPYAIAVVELEEGVRMMTNIVGV
                     EITPENLPLDMELRVVFEQRGDVRVPLFEPAGGPTR"
     misc_feature    complement(4363..4377)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.22"
                     /tool="antismash"
     gene            4433..5755
                     /locus_tag="HHX31_RS11875"
     CDS             4433..5755
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="HHX31_RS11875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_169948110.1"
                     /transl_table=11
                     /translation="MGLSYVRELDEYPTGGRRMKILTMAVLAVLIGSYEAQIAPVVPLL
                     LKDLDMSLATYGAVSGAAAVAGAVASAVGGRLTDRLGRVRLLVPLMLLTAVCCFGMTLV
                     HDPGDLLIARIVLAFVDGVAMASTAPLVRDFSPRLGRAQAFGFWTWGPVGANFLAAAVA
                     GWTLPIFDDSWRSQFVIMGCFSLVISIVIALNIADLSPELRAQIQHTERRSIDVVDLTR
                     PARVTSLFVRRNIWAHVIGISLWLVLYVTLTLFGQTMLVGALGITAAEASTIMACFWSL
                     NLITLIVAGRLSDRTQLRKPFTLGGTVAAVLVTAYLASLLGGQDVSSGMLMIVGALLGG
                     SLGVAYGPWMANYSEDAEDVDPRLQGTAWGLFGFLTKAIAVVGLLVIPHVVEATSWQTW
                     LVVSLVCLALFGPAVFLFHGPWRRERAETVDGSEARVAVAE"
     gene            complement(5871..6506)
                     /locus_tag="HHX31_RS11880"
     CDS             complement(5871..6506)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037625.5"
                     /locus_tag="HHX31_RS11880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_169948112.1"
                     /transl_table=11
                     /translation="MSAGGLRELKKSRTRQLIADTANALFRSRGFDEVTVDEIAAAAQV
                     SKKTVFNHFPTKEDLVFYRAEDREAMSLAAVTDRPAGVSILDSFRALCLAQTRLVPGMR
                     RDLDHPRGFFELVSGNPSLQRKMHEVNERIVRVLADALAAEAGAEPGDPLPGIVASTLV
                     GAQRTLYRRLRQRVAAGGPDEEIERAHRADVERVFGLLGAGLGGYPPA"
     gene            6577..7560
                     /locus_tag="HHX31_RS11885"
     CDS             6577..7560
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155727.1"
                     /locus_tag="HHX31_RS11885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_169948114.1"
                     /transl_table=11
                     /translation="MTYPAVVATGLTKHYDDVEAVRGLDLTVRRGEIFGFLGPNGAGKS
                     TTISMLCTLTTPTAGQARVAGYDVVRERDDVRRSIGLVFQDPTLDGYLTAERNLRFHAE
                     LYGVPRADVGPRLRGVLEMVGLWDRRGAKVATFSGGMRRRLEIARGLLHSPRVLFLDEP
                     TVGLDPQTRSSIWAYIRELKEAEDITVFLTTHYMDEAEHCDRIAIMDGGRVIALDTPDA
                     LKAGVGKDRVQIQADDGAAAVAALDERFGIRAVASGDVVVFHVDEGERFVPELFSRLGL
                     PIRSVSVARPSLDDVFMSYTGRSIRDAQVNGARGLGALAAARGGMR"
     gene            7557..8411
                     /locus_tag="HHX31_RS11890"
     CDS             7557..8411
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132401.1"
                     /locus_tag="HHX31_RS11890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_169948116.1"
                     /transl_table=11
                     /translation="MTLPITRVRVPGRGVASELRAIKVVWQRELIRFFNGPLRILTSLV
                     QPFLFLFVLGTGLSQLTSGGTGGLGLRTFLYPGILAMAVLFTAMSSAASIVWDREFGFL
                     REMLVAPVSRASIVVGKCLGGATVAAVQGLVVICIAGAAGVPYAPGLMLGVFGIQILLA
                     FTITAFGVAMSVRVRQMQSFMALNQLLIMPLYFMSGAMFPASNLPAWLAVLNRIDPLSY
                     AVDPIRRLVFAHLDLAPAVRDRLAPGMTWGGWHVPIPVEVAVLAALGLALLVTAVAQFG
                     RAD"
     gene            8668..9873
                     /locus_tag="HHX31_RS11895"
     CDS             8668..9873
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) Chlor_Efflux_Pump"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891893.1"
                     /locus_tag="HHX31_RS11895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Cmx/CmrA family chloramphenicol efflux MFS
                     transporter"
                     /protein_id="WP_169948117.1"
                     /transl_table=11
                     /translation="MPLSLYSLAVAVFAMGTSEFMLAGLLPDIAADLGVTVATAGTLTS
                     AFAIGMIAGAPLMAGLVRDRPPRSGLLAFVLVFVAAHVVGAATSNFPVLFASRIVAALA
                     NAGFLAVAVTTAAAVVPANRKGRALAVLLSGTTVATVAGVPGGAVLGAMFGWRVTFWAV
                     AVLCVPAAAGILWGIPARSGRAGEAGGRVPRPGLARELAQLRSPRLILAMLLGALVNAA
                     TFASFTFLAPVVTGAAGMDPLWIPVVLVLFGAGSFVGVTVAGRLSDQHSGLVIAAGGPL
                     LLIGWPALAVLAGEPALLLTLVFVQGALSFALGSTLITRVLYEAAGAPAMAGSYATAAL
                     NVGAAAGPLMAAATLGTAAGDLGPLWLSGLLVAIALLIALLIALPPAVVRRERPPWRAR
                     PR"
     gene            10001..11077
                     /locus_tag="HHX31_RS11900"
     CDS             10001..11077
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853353.1"
                     /locus_tag="HHX31_RS11900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_169948120.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5e-48, bitscore:
                     158.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGIVDTSITGMTGRVRRRVDELLAGFLDARRPPVGDQDVAEGY
                     RLLREFVVEGGKRIRPLLCYWGWRGAGGEAAHDDRAVATGAALELYHAGLLIHDDVMDG
                     SELRRGRPTIHTGLAGVPRRAAAETFGRSAAILLGVLAQAWADELFADATAADVRGRAA
                     RQLFNRMRTEVITGQYLDILAHTRADSDVEQALTVIRYKTARYTVERPMQIGGALAGAP
                     PALLDAYSRFGLPLGEAFQLRDDVLGVFGDPAVTGKPVLDDLREGKRTVLMANAYARAR
                     GPERDLLLTWHGDPGLDERRAAELRQVIVDTGALDEVEELIALRAAQAIEALGDPAIVP
                     EAARALAVLTERLTRRVR"
     gene            11238..12611
                     /locus_tag="HHX31_RS11905"
     CDS             11238..12611
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619264.1"
                     /locus_tag="HHX31_RS11905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_169948352.1"
                     /transl_table=11
                     /translation="MPNDNRLSLSTRAARNLATTTKTPPQMQEITSRHLLRVLPWIEAV
                     GGAYRVNRRLTYQMADGRVTFVSTGADVRVISAELCELPALRGFGDADVLAAMADLFTQ
                     REYESGQLIAEAGAPMDEVVLLAHGKVDKLGQGAYGNETLLGVLADGEYVGEQMLVNAD
                     ARWEWTVKAVTPCTVLALRREEFERLLTLSDGLREHVQAYHEDPDRPVNRYGEAEIALA
                     AGHVGEATLPGTFVDYELGPREYELSVAQTILRVHSRVADLYNEPMNQTEQQLRLTIEA
                     LRERQEHELVNNRDFGLLHNADLKQRVHTRSGPPTPDDLDELLAMVWKNPSVMFAHPKA
                     IAAFARQCNSRGIYPQTVEINGQKAPAWRGVPMLPCNKIPVNDKGISSIMVMRLGEKDQ
                     GVVGLRRTGLADEYEPGLSVRFMGIDDKAIISYLVTTYYSAAVLVPDALAILESVEVL"
     gene            12611..14833
                     /locus_tag="HHX31_RS11910"
     CDS             12611..14833
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073415.1"
                     /locus_tag="HHX31_RS11910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /protein_id="WP_249345872.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-78, bitscore: 259.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYRLPDFYLPYPPRLNPHVETARAHTRGWAADMGMLDDPDIWTA
                     ESLEAMDYGLMCAYTHPDCSAPELDLITDWYVWVFYFDDHFLETFKRGRDLDGAQDYLD
                     RLDAFMSDDPPEPSNPVERGLADLWPRTVPAMSEAWRHRFVLVTRDLLQESMWELFHIE
                     RDAVSNPIEYIEERRKVGGAPWSAALVEHAAGAELPARLAGSRPIRVLTESFADAVHLR
                     NDLFSYEREVLREGELSNCVLVCERFFGCDTDLAVEITNDLLTSRLHQFEHTALTELPA
                     LFADEGVLPPEQALVLSYVKGLQDWQAGGHAWHTASSRYTKSGGLPGPLGMNVSLAHLT
                     GAGGLRNHTHTPYQRVSVRLPKPYMPFEVRDNPHLDAARAADVEWCAAMGFFDGVPGIP
                     ATAVWNEPQLVGFDLALCASGINPDATAEELILATNWLAWGTYGDDYYPRVYGPARDLV
                     GAKLGNRRLKEFMPLDLVPRLTPMTGLERGLADLWPRTAGPLPEESRRDFRAAVEDMID
                     SWVWELDNQARHRVPDPIDYIEMRRATFGSQMTMSLARLAPGRVIPTEIHRTREFLGMT
                     DAAQDYACLLNDLFSYQKEVQFEGELHNAVVVLGTFFDCAPDEAVTAVDALMTSRMRQF
                     EHITTVDLPALLDRMEAREEVRESVDGYVSDLRNWMAAILRWHERSRRYFEEELRRGPT
                     ARWSQGPTGLGTAGARILSIAPPALTPPSGPAGLAADGLPLPVGAP"
     gene            14830..16182
                     /locus_tag="HHX31_RS11915"
     CDS             14830..16182
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630108.1"
                     /locus_tag="HHX31_RS11915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_169948122.1"
                     /transl_table=11
                     /translation="MTEPRDLPGASRLTLSTAAARNLATTTKTPPQMREITPRHLLRVL
                     PWTEVQGGVYRVNRRLTCTVGDGRVSFVSTGARVRVVPAELCELPSLRDFGDLDVLGAL
                     ADRFVQHDLRPEEPVPRGQVVLVAHGKIARVGAGAYGGEALLQVLADGDHLGDLAGPGA
                     APAKALTSCIVLVLERPALDNLTALSEGLREHLGRPVSARPVNRHGEAEIALAAGHVGE
                     ATLPGTFVDYEPGPREYELSVAQTILRVHSRVADLYNEPMNQTEQQLRLTIEALRERQE
                     HELVNNRDFGLLHNADLKQRVHTRSGPPTPDDLDELLARRRSSHYFLAHPRAIAAFGRQ
                     CTRRGVYPDVTEVNGATVMSWRGVPILPCDKIPVSEDGLSTIMVMRTGAEKQGVVGLRR
                     TGLADEYEPGLSVRFMGVDDKAIITYLVTTYYSAAVLVPDALGLLESVEVD"
     gene            complement(16244..17008)
                     /locus_tag="HHX31_RS11920"
     CDS             complement(16244..17008)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (12-169). E-value: 8.5e-10.
                     Score: 30.8. Matches aSDomain:
                     nrpspksdomains_HHX31_RS11920_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017627041.1"
                     /locus_tag="HHX31_RS11920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_169948124.1"
                     /sec_met_domain="adh_short (E-value: 2.6e-33, bitscore:
                     110.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.4e-35, bitscore:
                     117.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPAGGIFTGRVVVVTGAGSGIGRAAALAFARAGAQVLGVGRRA
                     HALEETARQHPGVAVLAADLRAADAPETIVRTAADRWGRVDVLVNNAGATTIMPLAETT
                     AARVTDLFDLNVTAPSLLARAALPHLRETRGSIVNISSTYGHRPLPGGAHYAASKAAIE
                     QLTRSWALELAGDGIRVNALAPGPTESEALVAAGLPESVVEQIKRDEARRIPIGRRGEP
                     REVAEWILRLADPAATWLTGQVLTVDGGLELT"
     aSDomain        complement(16502..16972)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX31_RS11920_PKS_KR.1"
                     /evalue="8.50E-10"
                     /label="HHX31_RS11920_PKS_KR.1"
                     /locus_tag="HHX31_RS11920"
                     /protein_end="169"
                     /protein_start="12"
                     /score="30.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVVTGAGSGIGRAAALAFARAGAQVLGVGRRAHALEETARQHPG
                     VAVLAADLRAADAPETIVRTAADRWGRVDVLVNNAGATTIMPLAETTAARVTDLFDLNV
                     TAPSLLARAALPHLRETRGSIVNISSTYGHRPLPGGAHYAASKAAIEQLTRSW"
     CDS_motif       complement(16898..16969)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX31_RS11920_0001"
                     /evalue="4.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="HHX31_RS11920"
                     /protein_end="37"
                     /protein_start="13"
                     /score="9.6"
                     /tool="antismash"
                     /translation="VVVTGAGSGIGRAAALAFARAGAQ"
     gene            17063..17410
                     /locus_tag="HHX31_RS11925"
     CDS             17063..17410
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017597672.1"
                     /locus_tag="HHX31_RS11925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_169948126.1"
                     /transl_table=11
                     /translation="MKQAHHPELDEISLTAVMAALSDPIRVGLVRLLADGREHGWGELR
                     APVAKSTLSHHLRVLRDAGITRTRQEGTRCFVVLRRDDLETRFPGLLVAVLAAAECDGV
                     GGQVGLAAHAE"
     gene            17498..18304
                     /locus_tag="HHX31_RS11930"
     CDS             17498..18304
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.5"
                     /locus_tag="HHX31_RS11930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_169948128.1"
                     /transl_table=11
                     /translation="MFVASDRVRGPEAASALGSLERGIEILLCLAAGTRPMNLTQVHQS
                     TGFSKTTTHRLLATLQRRGLVTRTGGDYTVGGRVADLVARRGWVIQGRHLPGSRRVVLP
                     HLLQLYEATRQTVNLAVPDGFEVAYVERLYGHNRVKSPSDGLDRAPLHCTAAGKVLLAH
                     DAGLRTAFLAAPALRRVTGRTVTGRKVTGPAALDRELAAIRGEGVGYARDEFAEGVCCA
                     AAPVFGPDGGVCMAVAVAAPAEAAALPRLGAAVRRTARQITGALSL"
     gene            18445..18963
                     /locus_tag="HHX31_RS11935"
     CDS             18445..18963
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS11935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169948130.1"
                     /transl_table=11
                     /translation="MRPGPYASRLIGRACLVVMPMALLLAACGTPQPQVRREPAATDAA
                     APATVAVTPSPAPSVVTAAADPRACLDADCEVAVRPGDRLRLDRKGLDEIEVVALGPGG
                     VRLRFEAGGGAYRVEGDNAGVSQECVNGRCHTDGALTLALGRPGRIGDIGLRLTSVSPD
                     HAVLVLSPA"
     gene            19058..19912
                     /locus_tag="HHX31_RS11940"
     CDS             19058..19912
                     /EC_number="2.8.2.-"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050656 - 3'-phosphoadenosine
                     5'-phosphosulfate binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540199.1"
                     /locus_tag="HHX31_RS11940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfotransferase"
                     /protein_id="WP_169948132.1"
                     /transl_table=11
                     /translation="MAWKSRVNAAVEGMTGYVITRARPRAVPAAEPRDAPRPPADPAAD
                     RLLRAPVFVLSPVRSGSTLLRVLLNSHSRIHAPHELHVRRVAVTLTTDPVRQAMEAAGH
                     RPSDIEHILWDRLLHRELVRSGKDVIVDKTPSNVFAYRRIMTCWPDARFVFLLRHPASI
                     ARSWHEADPKARPMDEAVRHTLQYMRHLEEARRRHEGIDVRYERLVDDTEGELRRICAW
                     LGVEYEPEMVRYGDKDHGDFVKGIGDWRDKIRSGRVQPGRPLPVPEDVPEALREIAAAW
                     RYL"
     gene            complement(19931..20128)
                     /locus_tag="HHX31_RS11945"
     CDS             complement(19931..20128)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS11945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169948134.1"
                     /transl_table=11
                     /translation="MDEPLPVRLADGRNLKCDTCENELFERHRWKLQTTGMTFMNLDWA
                     NRDATCFVCTGCRRIHWFHW"
     misc_feature    20130..20143
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.64"
                     /tool="antismash"
     gene            20234..20866
                     /locus_tag="HHX31_RS11950"
     CDS             20234..20866
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009463278.1"
                     /locus_tag="HHX31_RS11950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysE family translocator"
                     /protein_id="WP_169948136.1"
                     /transl_table=11
                     /translation="MDIYGAIASFAVIVAFLTLTPGLDTALILRTSLLAGRRPAWAVAL
                     GIQAGTLLWGLVTATGLSALLTASQVAYEVLRWAGVAYLIWMGGRMLWHSRDSRADDAA
                     QPGPADAGWGAAFRRGLLTNLLNPKVGAFYVAVLPQFMPEGVPHAVMGVLLAGVHGCQG
                     LVWSAVLIGFTGMVRGWLRRPVVKRALDRLTGLVVIGFGLRLAVQQP"
     misc_feature    20235..20251
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.81"
                     /tool="antismash"
     gene            complement(20918..22297)
                     /locus_tag="HHX31_RS11955"
     CDS             complement(20918..22297)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (12-289). E-value:
                     9.5e-30. Score: 95.6. Matches aSDomain:
                     nrpspksdomains_HHX31_RS11955_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="HHX31_RS11955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_169948138.1"
                     /sec_met_domain="Condensation (E-value: 1.3e-22, bitscore:
                     75.3, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTVTFSGARDGEAPLTWGQRLMWRAIHLMGDSQTFLSCPWVLPV
                     YGRRDLGSVLDALRVLLERHESLRTTFASTPDGPVQRVARDGELTVDMVESGQDRALRV
                     AERVADELGRTAFVHDKDLPLRCAVVLKNGRPTALALAFSHLAVDFQALNTLSEDWKIL
                     MRGEKPPPVEWQPMDQAAAEREEPYPARSAKSVRYWHSVLADGPLDVFDHPPREADDPR
                     FIEVGMESTALAVAAQRLAERWTMSTTSVLLAACATVLATVSGRPRAVMQLVHSNRRDP
                     RTRAMVGTVEQDGLFVLDLPGTDFAAACRAAQRGALRAYRNAHYDPFEMQAMREEIGRR
                     RGREPDLDAFFNDRRTTGTWPGLPPVGSDEDVARLVGQTRTYVTNAWPGVRFKAFFTVV
                     SAPDTGKLTLIVDTAYLPRDVAEAMLRGVEALLVRSLTEDVPMAAIPKVCGIGPYAGSP
                     T"
     aSDomain        complement(21431..22261)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX31_RS11955_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="9.50E-30"
                     /label="HHX31_RS11955_Condensation_LCL.1"
                     /locus_tag="HHX31_RS11955"
                     /protein_end="289"
                     /protein_start="12"
                     /score="95.6"
                     /specificity="C activity: active"
                     /specificity="Active site motif: SHLAVDF"
                     /tool="antismash"
                     /translation="EAPLTWGQRLMWRAIHLMGDSQTFLSCPWVLPVYGRRDLGSVLDA
                     LRVLLERHESLRTTFASTPDGPVQRVARDGELTVDMVESGQDRALRVAERVADELGRTA
                     FVHDKDLPLRCAVVLKNGRPTALALAFSHLAVDFQALNTLSEDWKILMRGEKPPPVEWQ
                     PMDQAAAEREEPYPARSAKSVRYWHSVLADGPLDVFDHPPREADDPRFIEVGMESTALA
                     VAAQRLAERWTMSTTSVLLAACATVLATVSGRPRAVMQLVHSNRRDPRTRAMVGT"
     CDS_motif       complement(22079..22132)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX31_RS11955_0001"
                     /evalue="1.10E-06"
                     /label="C2_LCL_024-062"
                     /locus_tag="HHX31_RS11955"
                     /protein_end="73"
                     /protein_start="55"
                     /score="21.0"
                     /tool="antismash"
                     /translation="DALRVLLERHESLRTTFA"
     gene            complement(22291..22566)
                     /locus_tag="HHX31_RS11960"
     CDS             complement(22291..22566)
                     /NRPS_PKS="Domain: PP-binding (9-78). E-value: 5.9e-08.
                     Score: 24.9. Matches aSDomain:
                     nrpspksdomains_HHX31_RS11960_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="HHX31_RS11960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="WP_169948140.1"
                     /sec_met_domain="PP-binding (E-value: 9.3e-08, bitscore:
                     27.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEEYTRRLAQLISEVSDGEITVEEVLAAGHTLSALGLTSPARI
                     RLIDAIEDDFGVEMDLSDEPASFEDVGTLSALVARAQAVRETTRAW"
     aSDomain        complement(22333..22539)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX31_RS11960_PP-binding.1"
                     /evalue="5.90E-08"
                     /label="HHX31_RS11960_PP-binding.1"
                     /locus_tag="HHX31_RS11960"
                     /protein_end="78"
                     /protein_start="9"
                     /score="24.9"
                     /tool="antismash"
                     /translation="LAQLISEVSDGEITVEEVLAAGHTLSALGLTSPARIRLIDAIEDD
                     FGVEMDLSDEPASFEDVGTLSALV"
     gene            23040..23927
                     /locus_tag="HHX31_RS11965"
     CDS             23040..23927
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS11965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="WP_169948142.1"
                     /transl_table=11
                     /translation="MTRHGFTLTARGPFDFGATLRFTEGWPVTGGLPADGRALRFAYCA
                     ESDWLPIGVTVTAAPDGVAVATTRAAGPAIREEVARILSLDVDGSGFAEIGEADPVLGD
                     LWRKSPGLRPLCFWSPWEAACWAVIVQRSSMLVAARIKQRIAERYGARVLVDGEPYAAF
                     PPPVTLLEADGLGLPAQKEEWLRGLARAALDGVLTTEHLRALDPLEALAELRALPGVGP
                     FSAGLILIRGAGAPDAFPGDEPRLFAILREAYGLPQDAPPAAYRKVAEAWRPYRSWASF
                     LFRASGYGGLGDGR"
     gene            complement(23935..24081)
                     /locus_tag="HHX31_RS11970"
     CDS             complement(23935..24081)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS11970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169948145.1"
                     /transl_table=11
                     /translation="MTTAPQATTWTTAARRHRFAAFLIDNLVLHDVLAGIVVVDVSSKA
                     PTA"
ORIGIN
        1 aatggccggt tgagttcaga actgcagttc ggcccagtcg acggtgatgg ggatcgggtt
       61 gctcacgacg ggagcctcgc cgggctcgtc cttcatgagg gtgccgatgt gcttgtagag
      121 catcgacgcc cggtccagcc ggtagcgctc gatggccgac acgccggtgc ggtccagccg
      181 gacgatccag tagtgcggga tgccggcctt ggcgtactca ccgagcttgt ccgtcgtgtc
      241 ctgggtctcc gatcccggag acacgatctc caccacgagc agcgcgtgct cggcacgaag
      301 acgctcaccc tgctcgcggt tgaggcaccg gtagagcgcg acgtcgggtc tgcggttgag
      361 caacggcagg tccctcaggc gcagatccac gtcattgttc acggtgaggc actcatgccc
      421 cttgctcatc gcggcgcgtg cgtgccgctc cagcaggttg gccagtcgcc tgccggcgat
      481 ccgctgatca ggcgtgggag cagcacagtg ggccacgtag ccgtcgacga tctcgatggc
      541 tttggcgatc tcctcgggga gcgcgtcgta ctcctccgcg gtgacgcggg tcggctgagg
      601 gcggatgctg agaagccaac tgtcatccgg cagagcggcc aatccggcgt ctcctcgtca
      661 ctgtccactg gacgagcaaa gcctacggtc agcggggccg aagcgccggg tgaccctcga
      721 gccgtcatcg ggatcggcac cgctggaacg acaccctgtt tccgttaccc ggcagagtcg
      781 gccggctttg acgcggggga gtacctcgtg gtcgcaccgg ccggtgtgat ctcactcaca
      841 tctcggcttg aacgattccg tcggggaagt tgcagaacac tgtcaatgat cagcgagaac
      901 gcgcttatgg ggcggttggg ccagggttac ggttacgggc acagcattca taatccccct
      961 atctaccaac tacccctcgt attacctttc tcccgttcct tcactgacgc atggggcgca
     1021 agtgacgtcc cacgacagac cagggagaaa tccatgaagc gcattctcgc cctcggcggg
     1081 gtcgcggcgg gcctgctggc cgccgccgcc gtcgccgcgc cggctcaggc cgacacggac
     1141 gtcgccccgc ccgtgaacct ggccaacacg aacttcgccg ctcagcaggt ggcggcgttc
     1201 tggtacggcc aggccaaggc gaacctgatc aacgcgacgc cgtacaacgt cgagacgacc
     1261 gtgccttcgc ggcacgtctc gaccggtggc gcttcggccg acagcaaggc cggtgtggtc
     1321 ggctccagtg gtgaccagaa ggccgccacg agcaacctga agaacgtcaa cctgccgaag
     1381 acgaccggca aggtgttctt catcggcgcg gacaacaagc cgcactggtg ctcggccacc
     1441 tcggtccaga gccagtacaa gaatctggtc gcgaccgcgg gtcactgtgt ctacgacacg
     1501 gtgagcaaca aggccaccct cgacaagtgg gtgttcatcc cgggttacta ccagggcaag
     1561 accccgtggg gcatctacgt gggtaagacc gcgtacaccc actacgacta cgacgtctac
     1621 gaggacggcg accgcgacta cgcgttcgtg acggtctaca acggcgtcca ggtcaccgac
     1681 gtgtcggccg acaaggtcaa gaactgggtc aagaaccgca cgttcgacac gcgcgcggag
     1741 gcggagaagg ccaagaagga cctcgagctc aagaccaccg gctggaccgg agagatcgtt
     1801 ccggtgcaca ccagcaagct cgcgaaggcg ggtgacaagg aggtcgagag gcggtacacg
     1861 cctatcgtgg caaaccaggc gaaggaggcc ctggggatcc gcagcaagga agaggccgag
     1921 gccctggctc gtggcgcgac ctccgaatgg gtgagtgagt acaagacgtc gggcatcacc
     1981 atcacccgtg tcagcagggc ggagttcggt cccggcgacg cggatcactg gtcggaagac
     2041 gagatgttct tctacttcca gaagaacaac ggcttctaca aggccagcat ttgggttctc
     2101 ttcgacgtgg acttcaagct gaagggtcac cttgtcgaca tcgctctgaa ggacgtcggc
     2161 accctgggtg gcaacgtcgg tggtcagggc ctggcctaca accagaaggt cgggaccgcg
     2221 gtcttcgtct tcggttaccc gagcgggtcg cacccggacg gcaactacgc cttctccggc
     2281 aagaccctca agtgggccta cggcaagacc ttcaaggccg ctgccccggc tctcaaggcc
     2341 gaggagctcg tcggcgtgaa gtcctccttc accggcgagg gctccatcgg ttcgtcctgg
     2401 ctgtaccgct acagcaacac caagcgtctc ggttacctca acggtgtgac catcgcggtc
     2461 tccgacaccg acggcaacaa gcgcatcgac accagcgtct ccccgtactt cgacggtgag
     2521 accctggccg tctaccagta cgccgcgaag ttcgcttccg gcaagatcgt ctgagcaccc
     2581 ctctgacgct ctgactggac caaggaaagg gcccggcctc cagccgggcc tttttcttgt
     2641 ccggtgcggt ggtcaggggc ggtggttgga caggacgagg gttgcggcgg aggcgaacat
     2701 gccgccgttg ccgaggacca cgctgatctc tacatcgggc acctgggcgg cggcctcgcc
     2761 gcgcagttgc cgtacggact cctggatggc gaacatcccg tacatgccgg tgtgggtgta
     2821 ggagaggccg ccgccgttgg tgttgagcgg gagacggccg ccgggggagg tgtggccctc
     2881 ggcgatgaac ggcccggcct cgccgcgctt gacgaagccg aggtcctcca ggccgtatat
     2941 cgggacgtgc gcgaaggcgt cgtagatcat gaggtggtcc acgtcgtcgt gcgcgatgcc
     3001 cgcctcggcg aaggcggcct cgccggagcg gcggaaggcg gcggaggtgg tgaagtcctc
     3061 catctgggag atgatcggcg actcggcgga ctcgccggag ccgagcaggt ggaccggcga
     3121 cctgcgggcg cgctcctcgg acgtcacgat cagcgcgccg ccgccgtcgg tgaccaggca
     3181 gcattccagc aggtggaagg ggtaggcgac catccgggag gcgagcacgt cctcgacggt
     3241 gatcaggtcc tggaacatgg cccgggggtt gcggtgcgcc caccggcgct gcgcgaccgc
     3301 gacctccgcg agctgctcgt gcgtgagccc ggtctccttc atgtagcgca gcgccgtcag
     3361 cgtgaacatg gtgggcgggc cgagcacgcc gtacggcatc tcgaactggc cgatcagcga
     3421 gtcggggccg agggccggcc ggggtgcgcc gacccgcgac cggcccgact cgccgtgggt
     3481 gatgagcacg gtcgtgcaca gcccggccct gatggccgcg gcggcgtgcc gtacgtggaa
     3541 gaggaaggac gagccgccca cgccggtgcc gtcgagccag gccggggcga ttccgagcgc
     3601 gtgggcgatc tggatcgggc ctggcacgcc gacggtggcg acgccgtcga tgtcgtcctt
     3661 ggtcatcccg gcgtcggcga gcgcgttgcg cgcggcctgg aggtggagct gcgcggtgga
     3721 catgtggggc agcttgccga gctcgtcggt ctcggccgcg cccgcgatga cgatgttcat
     3781 ctggtgggac ctccagcggg ctcgaagagg gggacgcgca cgtcgccgcg ctgttcgaac
     3841 accacgcgca gctccatgtc gaggggcagg ttctccgggg tgatctcgac gccgacgatg
     3901 ttcgtcatca tccgcacgcc ctcctccagc tccacgaccg cgatcgcgta cggcccgtcc
     3961 tgctcgaagc cgggagccgg gcgatggttg atcacgtacg agtagagggt ggccctgccg
     4021 ctggccgtca cccaggcgac gtcgtcggag ccgcagcggg ggcaggcggg ccgtggatag
     4081 aagtagtgcc gcgcgcaggc acggcagcgc tggatccgca ggactccctc cgccgtgccg
     4141 tcccagaacg gctgggtctc cggcgtcggc ttcgggacgg gtttgggcga tgcggtcatc
     4201 gttctcctct gaggcggagg gaagtcttag agctggattc tagaacctgg atctaagttt
     4261 ggcgagagcc ctctgccgcg ggctgagggc tccgtcgtcg cgcgggtccg gaacggctcc
     4321 tcactgcccc ttgactccgg cggtgaggag gcggaacatt catggaaatg aattctagag
     4381 cttgcttcta gaactcattc caggacgggg ggatgacgag aaaggcgtgt ctatgggcct
     4441 gtcctacgta cgcgagctcg acgagtaccc caccgggggc cgtcgcatga agatcctcac
     4501 gatggccgtg ctggccgttc tcatcggctc ctatgaggcg cagatcgctc cggtggtccc
     4561 cctgctcctc aaggacctcg acatgtccct cgcgacgtac ggcgcggtgt ccggggcggc
     4621 ggcggtcgcg ggggccgtcg cgtcggcggt cggcggcagg ctcaccgacc ggctcggcag
     4681 ggtgcgcctg ctggtcccgc tcatgctgct gaccgccgtg tgctgcttcg gcatgacgct
     4741 cgtccacgac ccgggtgacc tgctgatcgc caggatcgtg ctggccttcg tcgacggggt
     4801 ggcgatggcg agcaccgcgc cgctggtccg cgacttctcg ccgcgcctcg gccgggccca
     4861 ggcgttcggc ttctggacct ggggtcctgt gggggccaac ttcctcgccg ccgccgtcgc
     4921 gggctggacg ctcccgatct tcgacgactc ctggcggtcg cagttcgtca tcatgggctg
     4981 cttctcgctg gtcatctcga tcgtcatcgc gctcaacatc gccgacctgt cgcccgagtt
     5041 gcgcgcgcag atccagcaca ccgagcgccg gtccattgac gtcgtcgacc tgaccaggcc
     5101 ggccagggtc acctcgctgt tcgtccggcg caacatctgg gcgcacgtga tcggcatctc
     5161 gctgtggctg gtgctctacg tcacgctcac gctcttcggg cagaccatgc tggtcggggc
     5221 gctcggcatc acggccgcgg aggcgtccac gatcatggcg tgcttctgga gcctcaacct
     5281 gatcaccctg atcgtcgccg ggcgtctgtc cgaccgcacc cagttgcgca agccgttcac
     5341 cctgggcggc accgtggcgg ccgtgctcgt caccgcctac ctggcgtcac tcctcggcgg
     5401 ccaggacgtc tccagcggca tgctgatgat cgtcggagcg ctgctcggcg gctcgctcgg
     5461 tgtggcgtac gggccgtgga tggcgaacta ctccgaggac gccgaggacg tcgacccccg
     5521 gctgcagggc acggcctggg ggctgttcgg cttcctcacc aaggcgatcg ccgtggtcgg
     5581 cctgctggtc atcccgcacg tggtcgaggc cacgagctgg cagacctggc tggtggtctc
     5641 cctggtgtgc ctggcgctgt tcgggcccgc cgtcttcctg ttccacggcc cctggcggcg
     5701 cgagcgcgcc gagaccgtgg acggctcgga ggccagggtc gcggtggccg aataacagtc
     5761 aggccgaata acagtcaggc cgaataacag tcaggccgaa taacagtcag gccgaataac
     5821 agtcaggccg aataacagtc tggccgagta gcggtcaggc cgaacagcag tcaggccggc
     5881 gggtagccgc ccaggcccgc gccgagcagg ccgaagaccc gttcgacgtc cgcgcggtgg
     5941 gcgcgctcga tctcctcgtc gggcccgccc gccgcgaccc gctgacgcag ccgccggtac
     6001 agcgtccgct gcgccccgac cagcgtcgag gcgacgatgc cgggcagcgg gtcgccgggc
     6061 tccgcgcccg cctcggccgc cagcgcgtcg gcgagcaccc ggacgatccg ctcgttgacc
     6121 tcgtgcatct tgcgctgcag cgaggggttg ccgctgacca gctcgaagaa gccgcgcgga
     6181 tggtcgaggt cgcgccgcat gccggggacg agcctggtct gcgcgaggca cagcgcgcgg
     6241 aaggagtcga ggatcgagac cccggcagga cggtcggtga ccgccgccag ggacatggcc
     6301 tcccggtcct ccgcccggta gaagaccagg tcctccttgg tcgggaagtg gttgaacacc
     6361 gtcttcttcg acacctgcgc ggcagccgcg atctcatcca cggtgacctc gtcgaagccc
     6421 cgggaccgga agagcgcgtt ggcggtgtcg gcgatgagct ggcgggtccg gctcttcttc
     6481 agctcccgca gcccgcccgc actcatgggc acagcgtatc gtcccctttc ttacatctag
     6541 tgtactgtta caccaagtgt aaccaaaggg ggcgcgatga cgtatccggc ggtggtcgcc
     6601 accggtctga ccaagcacta cgacgacgtc gaggccgtac gcggtctcga tctgaccgtg
     6661 cggagagggg agatttttgg tttcctcggc ccgaacggcg ccggcaagtc cacgacgatc
     6721 agcatgctct gcacgctgac cacgcccacg gccggacagg cgcgcgtggc cggatacgac
     6781 gtggtgcgcg aacgtgacga cgtccggcgc tcgatcgggc tcgtcttcca ggacccgacg
     6841 ctggacggct acctcacggc cgagcgcaac ctgcgcttcc acgccgagct gtacggcgtg
     6901 ccgcgcgcgg acgtcggtcc gcggcttcgg ggcgtgctcg agatggtggg gctgtgggac
     6961 cggcgcgggg cgaaggtcgc gacgttctcg ggcggcatgc gacgacgact ggagatcgcc
     7021 cgcggcctgc tgcactcgcc gcgggtgctg ttcctcgacg agcccacggt gggcctcgac
     7081 ccgcagacca ggagctcgat ctgggcctac atcagggagc tgaaggaggc cgaggacatc
     7141 acggtcttcc tgaccaccca ctacatggac gaggccgagc actgcgaccg catcgccatc
     7201 atggacggcg gccgggtcat cgcgctcgac accccggacg cgctgaaggc cggcgtcggc
     7261 aaggaccgcg tccagataca ggccgacgac ggcgcggcgg cggtcgccgc cctggacgag
     7321 cggttcggca tccgggcggt cgcgtccggc gacgtggtcg tcttccacgt ggacgagggt
     7381 gagcggttcg tgcccgagct gttctcccgg ctggggctgc cgatccgctc ggtcagcgtg
     7441 gcaaggccca gcctcgacga cgtgttcatg tcctacaccg gccggtcgat ccgcgacgcc
     7501 caggtgaacg gcgcacgcgg cctcggcgcg ctcgcggcgg cgcggggagg catgcgatga
     7561 cattgccgat cacgagggtg cgggtgccgg ggcgcggcgt ggcgagcgaa ctgcgcgcga
     7621 tcaaggtggt ctggcagcgc gagctcatcc ggttcttcaa cggcccgctg cggatcctca
     7681 cctctctcgt ccagccgttc ctgttcctct tcgtcctcgg caccggcctg tcgcagctca
     7741 cctcgggcgg caccggcggg ctcggcctgc ggaccttcct ctacccgggc atcctcgcca
     7801 tggccgtgct gttcaccgcc atgtcatcgg cggcctccat cgtctgggac cgcgagttcg
     7861 gcttcctgcg ggagatgctg gtcgcgccgg tgtcccgcgc gtcgatcgtc gtcggcaagt
     7921 gcctgggcgg ggccacggtc gcggccgtcc aaggtctcgt cgtcatctgc atcgccgggg
     7981 cggcgggcgt tccgtacgcg ccgggcctga tgctcggggt gttcggcatc cagatcctgc
     8041 tggccttcac catcacggcc ttcggggtcg cgatgtccgt gcgggtgcgg cagatgcagt
     8101 cgttcatggc gctcaaccaa ctgctgatca tgccgctcta cttcatgtcg ggcgcgatgt
     8161 tccccgcgtc gaacctcccc gcgtggctgg ccgtgctcaa ccggatcgac ccgttgtcct
     8221 acgccgttga ccccatcagg cggctggtct tcgcccatct ggacctggct cccgccgtac
     8281 gggaccggct cgcgccgggg atgacgtggg gcggctggca tgtccccatc ccggtcgagg
     8341 tggcggtgct cgcggctctc gggctcgccc tgctcgtcac cgccgtcgcc cagttcggca
     8401 gggccgactg agcgtcggcg gcacggcccg gtgtgcggga aaacgggtgg acgccgacgg
     8461 gcgtcgggtg gatatcgtgt gggccatgtc gagccccgag gcatccaggg tgggggcttt
     8521 cggtcacgcc gtcagccccc tgcaccactg agttcgccaa tccgtcgtcc cgccgcgcgt
     8581 ccgcggccgg gcgcgtgcgc tcgcgggtgc tgaccgcggt gacgagacgc ctccttctcg
     8641 tgcttctcat cgcctcggag ccactcgatg cctctttcgc tctattcgct cgccgtggcg
     8701 gtcttcgcca tgggcacctc ggagttcatg ctcgccggcc tcctgccgga catcgccgcg
     8761 gacctcggcg tgaccgtcgc gacggcgggc acgctgacct cggccttcgc gatcggaatg
     8821 atcgccggag ccccgctcat ggccgggctc gtccgcgacc ggcctccccg gtccggcctc
     8881 ctcgctttcg tcctcgtctt cgtggcggcc cacgtcgtgg gcgccgccac ctcgaacttc
     8941 cctgtcctgt tcgcgagccg gatcgtcgcc gcgctcgcga acgcggggtt cctcgccgtg
     9001 gccgtgacga cggccgccgc cgtcgtcccc gcgaaccgta agggccgggc tctggccgtg
     9061 ctgctgtcgg gaacgacggt ggcgaccgtc gcgggggtcc cgggaggggc ggtgctcggc
     9121 gcgatgttcg ggtggcgggt cacgttctgg gcggtcgccg tcctctgcgt gcccgcggcc
     9181 gccggcatcc tctggggcat cccggcgcgt tccgggcggg cgggcgaggc cggcgggcgg
     9241 gtgccgcgac cgggactcgc gcgggaactc gcgcagctca ggagcccgcg cctgatcctg
     9301 gccatgctgc tcggcgcgtt ggtgaacgcg gcgaccttcg cgagcttcac cttcctcgcc
     9361 cccgtggtga ccggcgccgc tgggatggat ccgctgtgga tccccgtcgt cctggtgctc
     9421 ttcggcgcgg gctcgttcgt gggtgtcacc gtcgcgggac ggctgtccga ccagcactcc
     9481 gggctggtca tcgcagcagg cggcccgctt ctgctcatcg gctggccggc gctggccgtc
     9541 ctggccggag agccggccct cctgctcacc ctggtgttcg tccagggcgc gctgtcgttc
     9601 gccctgggca gcacgttgat cacgcgggtc ctctacgagg cggcgggagc gcccgccatg
     9661 gcgggctcgt acgcgaccgc ggcgctcaac gtcggcgcgg ccgccgggcc gctcatggcc
     9721 gcggccaccc tcggcaccgc cgcgggagac ctcggcccac tgtggctgag cgggcttctc
     9781 gtcgcgatcg ccctgctgat cgccctgttg atcgccctgc ctcccgcggt cgtgcggcgg
     9841 gagcgcccgc catggcgggc tcgaccccgc tgaaccgtgc gccttgaact gtgcgcaccg
     9901 gcgagaagtt ccgactatcg gaactggtgg ttctactttg cgtgttcatt aagtaacttt
     9961 ccgcgagggg aaaccggctc gtcgagcgag gagaccgacc atgacggcgg gaatcgtgga
    10021 cacgtccatc accggcatga ccggccgggt gcggagacgg gtcgacgagc tgctggccgg
    10081 tttcctcgac gcgcggcgtc cgccggtcgg cgaccaggac gtcgcggagg gctaccggct
    10141 gctgcgcgag ttcgtcgtcg agggcggcaa gcgcatccgg ccgctgctgt gctactgggg
    10201 ctggcggggc gcgggcggcg aggcggcgca cgacgaccga gccgtcgcca ccggcgcggc
    10261 gctggagctc taccacgccg gcctgctgat ccacgacgac gtcatggacg gcagcgagct
    10321 gcgccgtgga cggccgacca tccacacggg gctcgccggg gtcccgcgac gggcggcggc
    10381 cgagaccttc ggccggtccg ccgccatcct cctcggggtg ctcgcgcagg catgggcgga
    10441 cgaactgttc gcggacgcca ccgccgccga cgtgcgggga cgggcggccc gtcagttgtt
    10501 caaccggatg cgcaccgagg tcatcaccgg gcagtacctc gacatcctgg cccacacgcg
    10561 cgccgactct gacgtcgagc aggccctgac ggtgatccgc tacaagaccg cccgctacac
    10621 ggtggagcgc ccgatgcaga tcggcggggc gctcgccggg gcgccgcccg ccctgctcga
    10681 cgcgtactcc cggttcggac tgccgctggg ggaggcgttc cagctgcgcg acgacgtcct
    10741 cggcgtcttc ggcgaccccg ccgtgaccgg caagccggtc ctcgacgacc tgcgcgaggg
    10801 caaacggacc gtgctcatgg cgaacgcgta cgcgcgggca cggggacccg agcgcgatct
    10861 gctgctgacc tggcacggcg acccgggcct ggacgagcgg cgggcggccg agctccggca
    10921 ggtcatcgtc gacaccggcg cgctcgacga ggtcgaggag ctcatcgccc tgcgggccgc
    10981 gcaggcgatc gaggcgctgg gcgaccccgc gatcgtcccg gaggcggcgc gcgcgctcgc
    11041 cgtgctcacc gagcggctca cccgccgcgt ccggtgacgc gtgcgaccgg caggcgcggg
    11101 ccggggccct cccggtccgc gcgtccctga cctttctctc ctcccctccg ccggtccgcg
    11161 acgagcgtga ccagtcaccg aaacaccggc cgccgtgccg acaacagatg gggtgaagcg
    11221 ctgtgaccga aaccacgatg ccgaacgaca accggctcag cctgagcacc agggccgcgc
    11281 gcaacctggc cacgacgacc aagaccccgc cgcagatgca ggagatcacc tcccgtcatc
    11341 tgctgcgcgt gctgccgtgg atcgaggcgg tgggcggcgc ctaccgggtc aaccggcggc
    11401 tgacctacca gatggccgac gggcgggtga cgttcgtctc gacgggagcg gacgtgcggg
    11461 tcatctccgc cgagctgtgc gagcttcccg ccctgcgcgg cttcggcgac gccgacgtgc
    11521 tcgccgcgat ggcggacctg ttcacccaga gggagtacga gtccggtcag ctcatcgccg
    11581 aggcaggcgc tcccatggac gaggtcgtgc tcctggccca cggcaaggtg gacaagctcg
    11641 gccagggggc gtacggcaac gagacgctgc tcggtgtcct ggccgacggc gagtacgtcg
    11701 gcgagcagat gctggtgaac gcggacgcgc ggtgggagtg gacggttaag gccgtgacgc
    11761 cgtgcaccgt gctcgccctc cgcagggagg agttcgaacg gctgctcacc ctgtcggacg
    11821 ggctgcgcga gcacgtgcag gcctaccacg aggacccgga ccggccggtg aaccggtacg
    11881 gcgaggcgga gatcgcgttg gcggcggggc atgtgggtga ggcgacgctg ccggggacgt
    11941 tcgtggacta cgagctgggg ccgcgtgagt acgagctgag tgtggcgcag acgatcctgc
    12001 gggtgcattc gcgggtggcg gatctgtaca acgagccgat gaaccagacc gagcagcagt
    12061 tgcggctgac gatcgaggcg ttgcgagagc gtcaggagca cgagctggtc aacaaccgcg
    12121 acttcgggtt gttgcacaac gccgatctca agcagcgcgt gcacacccgc tcgggcccgc
    12181 ccacccccga cgacctcgac gagctgctcg cgatggtgtg gaagaacccg agcgtcatgt
    12241 tcgcccaccc caaggcgatc gcggccttcg cccgccagtg caacagcagg ggcatctacc
    12301 cgcagaccgt ggagatcaac ggtcagaagg cgccggcctg gcgcggggtg ccgatgctgc
    12361 cgtgcaacaa gatcccggtc aacgacaagg gcatcagctc gatcatggtc atgcgcctgg
    12421 gggagaagga ccagggcgtg gtcggcctgc gccgcaccgg gctggcggac gagtacgagc
    12481 ccggcctgtc ggtgcgcttc atgggcatcg acgacaaggc gatcatctcc tacctggtga
    12541 ccacctacta ttcggcggcc gtcctggtcc ccgacgccct cgccatcctg gagagcgtcg
    12601 aggtcctctg atgtcctacc ggctgccgga cttctacctc ccttatccgc cacggctgaa
    12661 cccgcacgtg gagacggccc gggcgcacac ccggggatgg gcggcggaca tgggcatgct
    12721 cgacgacccc gacatctgga ccgcggagtc gctggaggcg atggactacg gcctgatgtg
    12781 cgcctacacc catcccgact gctccgcccc ggaactcgac ctgatcacgg actggtacgt
    12841 gtgggtcttc tacttcgacg accacttcct ggagacgttc aaacgcggca gggacctgga
    12901 cggcgcccag gactacctgg accggctcga cgcgttcatg tcggacgacc cgcccgagcc
    12961 gtcgaacccc gtggagcggg gcctggccga cctgtggccc aggaccgtgc ccgccatgtc
    13021 cgaggcgtgg cggcacaggt tcgtcctggt cacccgggat ctgctgcagg agtcgatgtg
    13081 ggagctgttc cacatcgagc gggatgccgt ctccaacccg atcgagtaca tcgaggagcg
    13141 caggaaggtc ggcggcgcgc cgtggtcggc cgccctggtg gagcacgcgg ccggtgcgga
    13201 actgcccgcg aggctggcgg gctcccgccc gatccgggtg ctgacggagt cgttcgccga
    13261 cgccgtgcac ctgcgcaacg acctgttctc ctacgaacgg gaggtgctgc gggagggtga
    13321 gctgtccaac tgtgtgctgg tctgtgagcg tttcttcggc tgcgataccg atctggccgt
    13381 ggagatcacc aacgacctgc tcacctcccg gctgcaccag ttcgagcaca ccgcgctgac
    13441 cgagttgccg gccctcttcg ccgacgaagg ggtcctgccg cccgagcagg cgctggtgct
    13501 gagctacgtg aaagggctcc aggactggca ggcgggcgga cacgcctggc acaccgcctc
    13561 cagtcgctac accaaatcgg gaggcctccc cgggccgctc ggcatgaacg tctccctcgc
    13621 ccacctcacc ggcgcgggcg gcctgcgcaa ccacacgcac acgccgtacc agcgggtctc
    13681 ggtgcggctg ccgaagccgt acatgccgtt cgaggtgcgc gacaacccgc acctggacgc
    13741 ggcacgggcg gcggacgtcg agtggtgcgc ggccatgggc ttcttcgacg gggtccccgg
    13801 catcccggcg acggccgtgt ggaacgaacc gcaactcgtc ggcttcgacc tcgccctgtg
    13861 cgcgtccggc atcaacccgg acgccacagc cgaagagctg atcctggcca ccaactggct
    13921 ggcctggggg acgtacggcg acgactacta cccccgggtc tacgggccgg cgcgggacct
    13981 ggtcggggcg aagctcggca accggcggct caaggagttc atgccgctgg acctcgtgcc
    14041 gaggctgacc ccgatgacag ggctcgaacg cgggctggcc gacctgtggc cgcgcaccgc
    14101 ggggccgctg ccggaggaat cccgccggga cttccgcgcc gccgtcgagg acatgatcga
    14161 cagctgggtg tgggagctgg acaaccaggc caggcaccgc gtgcccgacc cgatcgacta
    14221 catcgagatg cggcgcgcga cgttcggctc gcagatgacg atgagcctgg ccaggctggc
    14281 gcccggccgg gtcatcccca cggagatcca ccgcacccgc gagttcctcg gcatgaccga
    14341 cgcggcccag gactacgcgt gtctgctgaa cgacctgttc tcctaccaga aggaggtcca
    14401 gttcgaaggg gagctgcaca acgccgtcgt ggtgctcggc accttcttcg actgcgcccc
    14461 cgacgaggcg gtgaccgcgg tggacgcgct catgaccagc cggatgcggc agttcgagca
    14521 catcaccacc gtcgacctgc ccgccctgct cgaccgcatg gaggcgcggg aggaggtgcg
    14581 ggagtcggtc gacggatacg tgtccgacct gcgcaactgg atggcggcga tcctgcgctg
    14641 gcacgagcgg tcccggcgct acttcgagga ggagctgcgc aggggtccca cggcccggtg
    14701 gtcgcagggc ccgacgggcc tcggcacggc cggcgcgcgc atcctgtcca tcgcgccgcc
    14761 ggcgctcacg ccgccctccg ggccggccgg cctcgccgct gatggtcttc cgctgccggt
    14821 gggggcgcca tgaccgagcc gcgcgacctt ccgggcgctt cgcgcctgac cctgagcacg
    14881 gccgccgcgc ggaacctggc gaccaccacc aagacgccgc cgcagatgcg ggagatcact
    14941 ccgcggcacc tgctgcgcgt gctgccgtgg accgaggtcc agggcggcgt ctaccgggtc
    15001 aaccgcaggc tcacctgcac ggtgggggac ggacgggtga gcttcgtgtc caccggtgcc
    15061 cgggtgcggg tcgtcccggc cgagctgtgc gagctgccgt ccctgcgtga tttcggcgat
    15121 ctcgacgtcc tcggagcgct ggccgaccgg ttcgtccagc acgacctgcg cccggaggag
    15181 ccggtgccgc ggggacaggt cgtgctcgtc gcccacggca agatcgcacg tgtcggcgcc
    15241 ggcgcgtacg gcggcgaggc cctgctccag gtcctggccg acggagacca cctgggcgac
    15301 ctcgcgggtc cgggggccgc gcccgccaag gcactcacct cgtgcatcgt cctcgtcctc
    15361 gaacggccgg cactggacaa cctgaccgcg ttgtccgagg gcctgcgcga gcacctcggc
    15421 cgtcccgtgt cggcgcgacc ggtgaaccgg cacggcgagg cggagatcgc gctggcggcg
    15481 gggcatgtgg gtgaggcgac gctgccgggg acgttcgtgg actacgagcc ggggccgcgt
    15541 gagtacgagc tgagtgtggc gcagacgatc ctgcgggtgc attcgcgggt ggcggatctg
    15601 tacaacgagc cgatgaatca gaccgagcag cagttgcggc tgacgatcga ggcgttgcgg
    15661 gagcgtcagg agcacgagct ggtcaacaac cgcgacttcg ggttgttgca caacgccgat
    15721 ctcaagcagc gcgtgcacac ccgctcgggc ccgcccaccc ccgacgacct cgacgagctg
    15781 ctcgcccggc ggcgcagctc gcactatttc ctcgcccatc cccgcgccat cgccgccttc
    15841 gggcggcagt gcaccaggcg cggggtgtat ccggacgtca ccgaggtgaa cggggcgacg
    15901 gtcatgtcgt ggcggggggt gccgatcctg ccctgcgaca agatcccggt cagcgaggac
    15961 gggctcagca ccatcatggt gatgcgcacc ggcgcggaga agcagggcgt ggtcggcctg
    16021 cgccgcaccg ggctggcgga cgagtacgag cccggcctgt cggtgcgctt catgggtgtc
    16081 gacgacaagg cgatcatcac ctacttggtg accacctact attcggcggc cgtcctggtc
    16141 cccgacgccc tcggcctgct ggagagcgtc gaggtggact gaggcgcgcc gcctccggcc
    16201 ggggacgctc gccgagcgcc ccggccggag gcgtccgccc gggtcaggtg agctccagac
    16261 cgccgtccac ggtgaggacc tggccggtga gccaggtcgc ggcggggtcg gcgagtcgga
    16321 ggatccactc ggccacctcc cggggctcac cacgcctgcc gatggggatg cggcgggcct
    16381 cgtcccgctt gatctgctcg acgacggact cggggaggcc ggcggcgacg agggcttcgc
    16441 tctcggtcgg gccgggcgcc agagcgttga cccggatccc gtccccggcc agttccagcg
    16501 cccagcttcg agtgagctgt tcgatcgcgg ccttcgacgc ggcgtagtgg gccccgccgg
    16561 gcagcggccg gtgaccgtac gtgctcgaga tgttgacgat cgacccgcgc gtctcgcgca
    16621 ggtgcggcag cgccgcccgg gcgagcaggc tgggtgcggt gacgttgagg tcgaacaggt
    16681 cggtgacgcg cgccgccgtc gtctcggcca acggcatgat cgtggtcgcg cccgcgttgt
    16741 tgaccagcac gtccacccgg ccccagcggt cggcggccgt gcgcacgatc gtctcgggcg
    16801 cgtcggcggc gcgcaggtcg gcggcgagca cggcgacgcc cgggtgctgc cgggcggtct
    16861 cctcaagggc gtgggcgcgg cggccgactc cgaggacctg tgctcccgcg cgggcgaagg
    16921 cgagggcggc ggcgcgtccg atgcccgagc ccgccccggt gacgacgacg actcggccgg
    16981 tgaagatgcc gcctgctggt ccggtcaacg cgactccagt tgttcgatgt tcgtcaaact
    17041 acgaacaagt taccattggc ccatgaagca ggcgcaccac cccgaactgg acgagatctc
    17101 cctcaccgcg gtcatggcgg cgctgagcga tccgatcagg gtggggctgg tccggctgct
    17161 ggccgacggg cgggagcatg gctgggggga gttgcgggca ccggtcgcca agtcgacgct
    17221 cagtcaccac ctgcgggtcc tgcgcgacgc cgggatcacg cgcacccgtc aggagggcac
    17281 ccgctgtttc gtcgtgctgc gccgcgacga cctggagacc aggtttcccg gcctgctcgt
    17341 cgccgtgctg gccgcggccg agtgcgacgg agtcggcggc caggtggggc tggcggctca
    17401 cgctgagtaa ccgcgttctt cccgcacagg cggcgcgacg cggctaaggt gaccgctggc
    17461 cggtcaagat ctggttggcg agcgtcgcgg ggggatcttg ttcgtagcgt cggatcgcgt
    17521 ccgtgggccc gaggcggcct ccgccctcgg cagcctggag cgcgggatcg agattctcct
    17581 gtgcctggcc gccggcacgc ggccgatgaa cctcacccag gtgcaccagt ccaccgggtt
    17641 ctccaagacc accacccacc gcctgctcgc gaccctgcag cggcgagggc tggtcacgcg
    17701 cacgggcggc gactacacgg tcggcggacg cgtcgccgac ctcgtggccc ggcgcggctg
    17761 ggtgatccag ggccgccacc tgcccggctc ccgcagagtg gtcctgccgc acctgctcca
    17821 gctgtacgag gccacccggc agacggtcaa ccttgccgtg ccggacgggt tcgaggtggc
    17881 gtacgtcgag cggttgtacg ggcacaaccg ggtgaaatcg ccgtccgacg gcctggaccg
    17941 ggcgccgctg cactgcacgg ccgcgggcaa ggtgctgctg gcccacgacg cgggcctgcg
    18001 tacggcgttc ctcgccgcgc cggctctgcg gcgggtgacc ggccgcacgg tgacgggccg
    18061 taaggtgacc ggcccggccg cgctcgaccg cgaactcgcc gccatccgcg gcgagggggt
    18121 gggctacgcg cgggacgagt tcgccgaggg cgtgtgctgc gccgcggcgc ccgtcttcgg
    18181 cccggacggc ggggtgtgca tggccgtcgc ggtcgcggcc ccggcggaag cggcggcgct
    18241 gccgcgcctg ggcgcggccg tgcgcaggac cgcccggcag atcaccggcg cgctcagcct
    18301 gtgactcccg atcttccgat tggggccggc gcgtccgggg aaggctcgac caggtcacgc
    18361 atcggggccc gcgccgacgc cgccacggcg gagacgcccg gccgccggtg ccacggaacg
    18421 gcacagccgt cgcgggggag agtcatgcgt ccagggccgt acgcgtcccg cctgatcggc
    18481 cgggcctgcc tcgtcgtcat gccgatggcc ttgctgctcg cggcgtgcgg gacgccgcag
    18541 ccgcaggtgc ggcgggaacc cgccgccacg gatgccgccg cgccggccac ggtcgccgtg
    18601 acgccctcgc ctgctccgtc ggtcgtcacg gccgcggccg acccgcgggc gtgcctggac
    18661 gccgactgcg aggtggcggt ccgcccgggg gaccggctgc ggctcgaccg gaagggcctc
    18721 gacgagatcg aggtcgtcgc gctcggcccg ggtggggtgc ggctgcgttt cgaggcgggc
    18781 ggaggggcct accgcgtcga gggcgacaac gccggagtca gccaggagtg cgtcaacggc
    18841 cgctgtcaca ccgacggcgc gctgacgctg gccctgggac ggcccggcag gatcggcgac
    18901 atcggcctcc ggctcacgag cgtgtcgccc gaccacgccg ttctggtcct gtcgccggcg
    18961 tgaccgcgac cggcgcgccc ggctcggctg tctcgacttc ggaaatcccc agcctccgtt
    19021 aaccgcgagg ccaccacgcc tccctacggt cgcggccatg gcatggaaga gcagggtcaa
    19081 cgccgccgtc gaagggatga ccggttacgt catcacgcga gcccggccgc gggccgtacc
    19141 cgccgcggaa ccgagagacg cgccgcgccc gcccgccgat cccgccgccg accgcctgct
    19201 gcgcgcgccc gtcttcgtgc tctcaccggt caggtccggc tccacgctcc tgcgcgtgct
    19261 gctgaacagc cacagcagga tccacgcgcc gcacgaactg cacgtccggc gggtcgccgt
    19321 gaccctcacc accgatcccg tacggcaggc catggaggcg gccggccacc gcccgagcga
    19381 catcgagcac atcctgtggg accgcctgct gcaccgggaa ctggtcagga gcggcaagga
    19441 cgtcatcgtg gacaagacgc ccagcaacgt gttcgcctac cgccgcatca tgacgtgctg
    19501 gccggatgcc cggttcgtct tcctgctgcg ccatcccgcg tcgatcgcca ggtcctggca
    19561 cgaggccgac ccgaaggcgc ggcccatgga cgaggccgta cggcacacgc tgcagtacat
    19621 gcgccacctg gaggaggcca ggcgccggca cgaagggatc gacgtcaggt acgagcggct
    19681 cgtcgacgac acggagggcg agctgcggcg gatctgcgcc tggctggggg tcgagtacga
    19741 gccggagatg gtccggtacg gcgacaagga ccacggcgac ttcgtgaagg gcatcggcga
    19801 ctggcgcgac aagatccgga gcgggcgggt ccagcctggc cgcccgctgc ccgttcccga
    19861 ggacgtgcca gaggccctgc gagagatcgc ggccgcctgg cgctacctat gagctccgct
    19921 caccgtccgc tcaccagtgg aaccagtgga tgcgacggca accggtgcat acgaagcacg
    19981 tggcgtcgcg gttggcccag tcgagattca taaacgtcat gcccgtggtc tgcagcttcc
    20041 agcggtgccg ctcgaacagc tcgttctcgc acgtgtcgca tttcaggttg cggccgtccg
    20101 ccagccttac cggcagtggt tcgtccatgt tttgatgcta aaccgcggtt cattttggcg
    20161 gcctgccgag agaatccccg gtgaccggaa tccccgatgt gcgggatgcg ggcgtgggct
    20221 acggtgaccg atcgtggaca tttacggggc gatcgcatcg ttcgccgtca tcgtggcatt
    20281 cctcacgctc acgccgggtc tggacaccgc cctgatcctg cgtacgtcgc tgctcgccgg
    20341 ccggaggccg gcctgggccg tggcgctcgg catccaggcg ggcaccctgc tgtggggcct
    20401 ggtcacggcc accggcctgt ccgcgctcct caccgcctcc caggtggcgt acgaggtgct
    20461 gcggtgggcg ggcgtcgcgt acctgatctg gatgggcggc aggatgctct ggcacagccg
    20521 cgacagccgg gcggacgacg cggcgcagcc cggcccggcg gacgccgggt ggggagcggc
    20581 gtttcggcgg ggcctgctga ccaacctgct caacccgaag gtgggcgcct tctacgtcgc
    20641 ggtgctgccc cagttcatgc ccgagggcgt gccgcacgcg gtgatgggcg tgctcctggc
    20701 gggcgtccac gggtgccagg ggctcgtgtg gagcgccgtg ctcatcgggt tcaccggcat
    20761 ggtgcgcggc tggctgcgca ggcccgtggt caagcgcgcc ctggaccggc tcaccggcct
    20821 cgtcgtcatc ggcttcggcc tgcgcctggc ggtccagcag ccctgacctc ccacctcgaa
    20881 tcgaggggcc tcagccccag ccatcaccct gggagctcta ggtcgggctc ccggcgtacg
    20941 ggccgatccc gcacaccttg gggatggcgg ccatcgggac gtcctcggtg agcgagcgga
    21001 ccagcagggc ctcgacgccg cgcagcatcg cctcggcgac atccctgggc aggtacgcgg
    21061 tgtccacgat gagggtgagc ttcccggtgt cgggggccga gacgaccgtg aagaacgcct
    21121 tgaaacggac acccggccag gcgttcgtga cgtacgtccg ggtctgcccg acaaggcggg
    21181 ccacgtcctc gtcagagccg acggggggca ggcccggcca ggtgccggtg gtccgcctgt
    21241 cgttgaagaa cgcgtcgagg tccggctcgc ggccgcggcg gcggccgatc tcctcccgca
    21301 tggcctgcat ctcgaacggg tcgtagtgcg cgttgcggta cgccctgagc gcccctcgct
    21361 gcgcggcgcg gcaggcggcg gcgaagtccg tgcccggcag gtcgagcacg aacaggccgt
    21421 cctgttccac ggtgccgacc atcgcgcggg tgcgcgggtc gcggcggttg ctgtgcacga
    21481 gttgcatgac cgcgcgcggg cggccgctca ccgtggccag cacggtggcg caggccgcga
    21541 gcagcacgct ggtggtgctc atcgtccagc gctccgccag tcgctgcgcc gcgacggcga
    21601 gcgccgtcga ctccatgccg acctcgatga accgggggtc gtcggcctcg cgcggcggat
    21661 ggtcgaacac gtcgagcggc ccgtccgcca gcactgagtg ccagtatcgg accgacttgg
    21721 ccgagcgggc ggggtacggc tcctcgcgct ccgcggcggc ctggtccatc ggctgccact
    21781 cgacgggcgg cggtttctcg ccgcgcatca ggatcttcca gtcctccgag agagtgttca
    21841 gcgcctggaa gtccaccgcg aggtgggaga aagccagtgc cagcgccgtc gggcggccgt
    21901 tcttcagtac gacggcgcag cgcagcggca ggtccttgtc gtggacgaag gccgtccggc
    21961 ccagctcgtc cgcgacccgt tcggcgaccc gcagcgcccg gtcctgtccc gactccacca
    22021 tgtccacggt cagctcgccg tcgcgggcga cccgctgcac cggcccgtcc ggggtcgagg
    22081 cgaaggtcgt acgcaggctc tcgtggcgtt cgagcagcac gcgcagcgcg tccaggacgc
    22141 tgccgaggtc gcgcctgccg tacaccggga gcacccacgg gcagctcagg aaggtctggc
    22201 tgtcgcccat caggtggatc gcccgccaca tcagccgctg tccccaggtc agcggcgcct
    22261 ctccgtcccg tgctccgctg aacgtcaccg tcaccatgcg cgtgtcgtct ctcggacggc
    22321 ctgggcccgg gccaccaggg cggacagggt gccgacgtcc tcgaaggagg ccggctcgtc
    22381 gctcaggtcc atctcgacgc cgaagtcgtc ctcgatcgcg tcgatgagcc ggattcgggc
    22441 cggcgaggtg aggccgagcg ccgacagcgt gtggccggcg gcgagcacct cctcgacggt
    22501 gatctcgccg tccgacacct ctgagatcaa ctgggccagc cggcgtgtgt actcctcagc
    22561 cgtcacgcca caccctcctc tcgtacgacc gcgtcccggg acgaccgcgg ggcggcaggc
    22621 cggtcgcgac cgtctcggcg tggtcgcgag gctccggtcc cgtgccctcc gaacccgtgc
    22681 cctccgaact cgtggtccgc cggtcgtcag gagcacgcaa gccgacggtg gccgggcggg
    22741 gtgatcccgc ctccacgcgc catcctcgcc ttgagtaacc gaaaagtttc gtcacgacgg
    22801 cctgctccgc gatcggcaca gaaatgccag ttagtccggt ttatggtcac ggggaaaatc
    22861 ccatactccc gaagaatagg caacaacggt ggtatggcga cagtgaaaac cgaaagtcgt
    22921 tcaccgaaag ctttcggctg acagggtccc ggctcgcggc gcgtcggcga ggcgggacgg
    22981 cgggccgggc caccccgccg gaagatcgtc tgtcggtctc cgctcatacg atgaggccca
    23041 tgaccaggca cggtttcacc ctcacggcac gcggtccttt cgacttcggc gccaccttgc
    23101 gcttcaccga gggctggccg gtcaccggcg ggctgcccgc cgacgggcgg gcgctgcgct
    23161 tcgcctactg cgcggagtcc gactggctgc cgatcggcgt gaccgtgacc gccgcgcccg
    23221 acggggtcgc cgtcgccacg accagggccg ccggcccggc gatccgcgag gaggtggcgc
    23281 gcatcctctc cctcgacgtg gacggctccg gcttcgccga gatcggcgag gccgacccgg
    23341 tgctcggcga cctgtggcgg aagagccccg ggctgcgccc gctgtgcttc tggagcccct
    23401 gggaggcggc ctgctgggcg gtcatcgtgc agcgctcgtc gatgctcgtc gccgcccgga
    23461 tcaaacagcg catcgcggag cggtacggcg cgcgggtgct cgtggacggg gagccgtacg
    23521 ccgccttccc cccgcccgtg accctgctgg aggcggacgg gctcggcctg cccgcgcaga
    23581 aggaggagtg gctgcgtggg ctggcccgcg cggcgctcga cggcgtgctc accaccgagc
    23641 acctgcgggc gctcgacccc ctggaggcgc tggccgagct tcgcgcgctg cccggcgtgg
    23701 ggccgttctc tgccggtctg atcctcatcc gcggcgcggg cgcgccggac gcgtttccgg
    23761 gcgacgagcc ccgcctgttc gcgatcctgc gcgaggcgta cggcctgccg caggacgctc
    23821 cgcccgccgc gtaccggaag gtggccgagg cgtggcggcc ctaccgctcc tgggcctcct
    23881 tcctgttccg ggcatccggg tacggcggcc tcggcgacgg gcggtgaacg gcggctacgc
    23941 cgtcggcgcc ttcgaggaca cgtccaccac gacgatcccg gcgaggacgt cgtgcaggac
    24001 cagattgtcg ataaggaagg cggcgaaacg atggcgccgg gcggcggtcg tccatgtcgt
    24061 cgcctggggg gcggttgtca tggccgcaag aacgacgcac ccacgcggca cggggattcg
    24121 gcatatcccg gacgtatcga aaaccgcata cgccaccgcg acagccccgc gtcttcgatg
    24181 agggcgtgaa ccggcgcgca ccaccgccgg cgccggattc gtcgaccgag gaaggctctg
    24241 acatggacct gagttcgaga ggtggcgtgg accggcggcg gctggtcaag tggggcgggc
    24301 tggcggccgc cgggctcgtg gcggccggcg ggccgctggc gagcgccggg gccggccacg
    24361 ccgccccgac tcccaccggc tcgccccgcc gcgaccggat cccgcgggac accctgcccg
    24421 gcggcgccta cgaccggtac gtggcacgcc tggccgccga gcgcgggttc tcgggtgtgg
    24481 tgatgctgtc gcaccagggc cgtacggtgc tgtcccgcag ctatggcatg gcggacaggg
    24541 agaaggggat tcgcaatcac gagggcaccg cgttcagcct cagctcggcc ggaaagccgt
    24601 tccacgcggt ggcgattctg caactggcgc agcgcggcag ggtgcggctg tccgacccgc
    24661 tgggcgagca cctgacgggt ctcgacccgg aggtcgccag gcgggtgacc atccaccacc
    24721 tgctgtccgg cacctccggg ctggacagtc cggccgagga cgtgcaacgc gtcttccaga
    24781 gccgggcgga ggtgagcgac cactacctgc ggcgggcccg gcaggcgaag ctg
//
