LOCUS       NZ_JABBWV010000003     23745 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H11081 NODE_3, whole genome shotgun sequence.
ACCESSION   NZ_JABBWV010000003
VERSION     NZ_JABBWV010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H11081
  ORGANISM  Microbispora sp. H11081
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 601605)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 601605)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Anotibioctics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012999535.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:41:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,738
            CDSs (total)                      :: 6,662
            Genes (coding)                    :: 6,604
            CDSs (with protein)               :: 6,604
            Genes (RNA)                       :: 76
            rRNAs                             :: 5, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1 (5S, 16S)
            partial rRNAs                     :: 1, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 58
            CDSs (without protein)            :: 58
            Pseudo Genes (ambiguous residues) :: 0 of 58
            Pseudo Genes (frameshifted)       :: 7 of 58
            Pseudo Genes (incomplete)         :: 54 of 58
            Pseudo Genes (internal stop)      :: 2 of 58
            Pseudo Genes (multiple problems)  :: 5 of 58
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:04:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4957
            Orig. end                         :: 28702
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBWV010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23745
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23745
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23745
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13745](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13745
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(62..76)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(636..1349)
                     /locus_tag="HHX31_RS09620"
     CDS             complement(636..1349)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894610.1"
                     /locus_tag="HHX31_RS09620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_169947352.1"
                     /transl_table=11
                     /translation="MLTVDFNRLPVGPGDRVLDLGAGGGRHAFEVLRRGADVVAFDMDA
                     AEMESVAAMFAAMDKEGEVPAGATGETVVGDALGMPFPDALFDRVIAAEVLEHIPDDMA
                     AMREIVRVLKPGGRAAITVPSFLPERICWALSEDYHTAPGGHIRIYTLAELQAKLKSSG
                     LEVGGHHYAHGLHSPYWWIKCAVGVNDDGHPLAKAYHELLVWDIMKRPLATRLAEAVLN
                     PLIGKSVVVYVRKPA"
     gene            complement(1398..2639)
                     /locus_tag="HHX31_RS09625"
     CDS             complement(1398..2639)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291020.1"
                     /locus_tag="HHX31_RS09625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_249345852.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 4.3e-30,
                     bitscore: 99.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAERLRVALLSYRSKPTCGGQGVYLRHISRELVALGHHVEVFSGQ
                     PYPELDEGVILNKVPSLDLYRDEDPFRTPKRDEYRDWIDALEVATMWTAGFPEPLTFSL
                     RAYRELKARRGDFDVVQDNQTLGYGLLGIKRLFPVVGTIHHPISVDRRIELKAAKGWKR
                     LSMRRWYGFVRMQSVVAPRLSPILTVSESSLADIHRDFNVPQSSMRLIPLGVDTRFFHP
                     RPELPKRDNSIVAVASADSPMKGVATLLRAVAKLATEREVNLTVVSRPTPGGPTEQLVS
                     ELSLHDRVRFVHGIPDEELAELIATSEVAVVPSLYEGFSLPAVEHMACGTPLVASRTGA
                     LPEVVGDAAVQVTPGDAEELAGVLRRLLDSPAERAEFGRRGYERVMERYAWPVVARRTV
                     EAYHEAIAAHTRSR"
     gene            2907..3926
                     /locus_tag="HHX31_RS09630"
     CDS             2907..3926
                     /EC_number="4.2.1.47"
                     /GO_function="GO:0008446 - GDP-mannose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0019673 - GDP-mannose metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0042351 - 'de novo' GDP-L-fucose
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894608.1"
                     /locus_tag="HHX31_RS09630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="WP_169947356.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.6e-09, bitscore:
                     31.7, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARRALITGITGQDGSYLAEHLLSEGYEVWGLVRGQANPRVPRVR
                     RLLQDVRLVRGDLLDQGSLISAVEKAQPDEVYNLGAISFVPMSWEQAELTGEVTGMGVL
                     RVLEAIRVCSGITASRGSATGQIRFYQASSSEMFGQVRETPQTERTPFHPRSPYGVAKA
                     YGHFLTQNYRESYGMFAVSGILFNHESPRRGAEFVTRKVSLGVARIKLGMAAELRLGNL
                     GARRDWGFAGDFVRAMHMMLSAAEPEDYVIGTGRTHSVRELVEAAFAAADLDWERYVVC
                     DAALHRPAEVDLLCADPKKARTQLGWEPTVSFEELVAMMVEADLRLLADGGDPDGVIL"
     gene            complement(4113..5084)
                     /locus_tag="HHX31_RS09635"
     CDS             complement(4113..5084)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020962.5"
                     /locus_tag="HHX31_RS09635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type IV toxin-antitoxin system AbiEi family
                     antitoxin"
                     /protein_id="WP_169947358.1"
                     /transl_table=11
                     /translation="MEEYLSSPLASAYGLSRSDTSRLVSTGRFWRVTRGGLYAGPDPRA
                     LAVRAHALGITSRDVVACRRTAAWLWGLDVLPPGKRHDEWPVEVVVPSGGRTPPRRAYV
                     VGRQSDRLPPGDVTSIGGVTVTTQERTALDCARWLPRLEAVAALDQFLARGVPEERLRG
                     RAAELAGRRNAKRLREVVALGDAGAQSPPESWVRVLVVDAGLPRPRSQVRVELPGERVA
                     YLDMGIERYRVGIEYDGHDHHSSAQDRAHDEWRRAEIRRLGWRLVIIRKDELFGSPATF
                     LERVAERLWEAGWRPTPEESVRLQRQLRLLGSPEARHRRYAA"
     misc_feature    complement(4218..4220)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(5353..5366)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.23"
                     /tool="antismash"
     gene            complement(5370..6578)
                     /locus_tag="HHX31_RS09640"
     CDS             complement(5370..6578)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655472.1"
                     /locus_tag="HHX31_RS09640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_169947360.1"
                     /sec_met_domain="p450 (E-value: 1.9e-16, bitscore: 54.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIDLVDKDRYARGGVPHEQFRLLRESTPVYWHEGQDGWPDFWAI
                     TKHADVVHVSRHSDLFSSARKLALFDEMPEEQREFQRLMMLNQDPPDHTRRRSLVNRGF
                     TPRQIGRLEEHIRDICHALVDEVQGEPEVDFVRDIAAPLPLYVICELLGAPVEDREKIF
                     EWSNRMIGNDDPDYAEGPEEGRAAALEVYSYAHALGEARRREPRDDIVTRLLRPDEDGQ
                     TLTRDEFDLFVLLLIVAGNETTRNAASGGMLTLFEHPDQWKRLVDDPSLAATAADEIVR
                     WVSPVNMFRRTATADTEIRGQKIAAGDKVVVFYSSANRDAEVFERPDEFDIGRDPNPQI
                     GFGGGGAHFCLGNHLAKLELRVLFEVLAQRLPGLSQAGEARRLRSNFINGIKSLPVTPT
                     PLP"
     gene            complement(6726..9563)
                     /locus_tag="HHX31_RS09645"
     CDS             complement(6726..9563)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.5"
                     /locus_tag="HHX31_RS09645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_283244446.1"
                     /transl_table=11
                     /translation="MASGRPVLLHRDKELDVVDDMLAGLSDGRPAVLVIQGTRGSGKTR
                     LLHAALARRPGGVVLSARGHADERSFAFGVVRQLFDPMMSGAGRAEAGAPAAVLDANAH
                     APAMTAVPYDGSAPGVPATLLDDLYRATRSLTAGQPLIIAVDDLNHADPQSAQWCSYIA
                     RRLDGLPIAMILTCDAEDRTAGETVRDILTLPYARSLRPSPLCRNCAATLIGSVLGASV
                     DDEIVAACHDLTKGNPLLLLETAARLAAADVLPERAELPRVLRIGAIALSETVLEWVAG
                     RYPSLLTLLQSLAIIAPYAGLETAAMLAGYGAVAAEEAGQALAGAGLLEGSPPQRFTHD
                     LVQSTILARMDPRARDEMHRRAASLLHRLGSPPKRPARHLLSASPTGDPWAVSVLREAA
                     REAVSENAWEDATRYLHRALATAKGPAILQVTAELGAVEMHLDIPACLRHLRAVTVLAG
                     DVGERADSLSPFATTLLTLNSPEAASAFCDIARGFDDDPAGRLADRREALLRLSAQALL
                     TGQSYGSRAAMRLLGAESGAGAGAQDYLATAALSCAARGRHRERTLALARRCLDGGGPI
                     PPTLVVALLWAGRVDEAAYWSEQVAADARANASTTGQALAVTLLSDIAYRRGELRASLA
                     HAREAILFARGSHALGLHAAAVSCAARVLLERDELDVAHALFDEVAAREPVHPFLHGAL
                     LEAQGRVAVARGDVREGLRALLEAGRQLLSAGVVNPACGGWRGQAALAYLRLGQRVAAR
                     RLAEEELELARAWGAPYGIGRALSTMSATVEGGRRVDLLVEALTVLDGTEGGIERVRAM
                     VRLGVALRASGDARRAHDTLSEAHALADGRGAVRLAALAERNLAGVGGRPRGGPAGGPS
                     PLTAGEMRVTDLVLRGMSNLQVATELSISKRTVDTHLARIYRKLGIHTRAELAETINRL
                     RERQTETRRWPGQEE"
     misc_feature    complement(9586..9600)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.59"
                     /tool="antismash"
     misc_feature    complement(9588..9601)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.57"
                     /tool="antismash"
     gene            10001..12268
                     /locus_tag="HHX31_RS09650"
     CDS             10001..12268
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="HHX31_RS09650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_169947364.1"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 3e-18, bitscore:
                     60.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 2.6e-12,
                     bitscore: 41.7, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 1.8e-12,
                     bitscore: 42.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 9.4e-90, bitscore: 296.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 7.9e-78, bitscore:
                     256.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERPRLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVIPYLDG
                     RHTVMDIVQALAGELSPAQAVLAVRRYEAAGHLVEGRPPLTDPLLAFWDAQGIDPAAVV
                     TALERTSFRVFAGSGVDPAPVEALLREHGLRTDPHDGGMGDMVVAVVDDYLDPGLEELN
                     AECLAAGRPWVLVRPAGTVAWLGPLFQPGDTGCWACLSQRLAGNRQVERYLAGKRGRGE
                     APSHPVREALPGGVAAVGGLLAAELVRTAATGKPSTLQGTMITVDLRTLTSAEHQLIRL
                     PQCPACGDPALIREREPKVALAARTARHVTDGGYRVEQPSATYARLERHVSPYLGAVTG
                     LRPWNGEDNGVTYSFTAGHNFAMLGDNMDLLRRNLRGQSGGKGRTEIQAKVSALCEAIE
                     RYSGVWRGEEPVLKAAYADIEQGRAVHPDDLLLFSERQFGDRSAWNSDPSHRLHLVPER
                     FRTDLPLDWSRAWSLTADEERLVPAGYAWYGHPDLERHFYCVGDSNGSASGNTLEEAIL
                     QGFCEVVERDAVALWWYNRVRRPAFDLDSLNEPYIDTLREFYADMGRSLWLLDLTTDLG
                     VPAFAGVSHRLDHPVQDVIVGFGSHLDPRIAALRTLTEVNQFLPSVRRRDENGETIYHD
                     DDIATLRWWKETTVESDPWLLPDPAQRPRTLADYAVPQDTDLAADVETCVSRAAACGLE
                     MIVLDQTRPDLELSVARVLVPGMRHFWRRLGPGRLYDVPVSLGWRTRPATEEELNPTSV
                     FF"
     aSDomain        10004..10282
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX31_RS09650_NHLP_CD_RRE.1"
                     /evalue="1.60E-19"
                     /identifier="RREFam015.1"
                     /label="HHX31_RS09650"
                     /locus_tag="HHX31_RS09650"
                     /protein_end="94"
                     /protein_start="1"
                     /score="60.7"
                     /tool="antismash"
                     /translation="ERPRLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVIPYLDGR
                     HTVMDIVQALAGELSPAQAVLAVRRYEAAGHLVEGRPPLTDPLLAFWD"
     aSDomain        10013..10234
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX31_RS09650_Cyanobactin_D_RRE.1"
                     /evalue="1.40E-13"
                     /identifier="RREFam007.1"
                     /label="HHX31_RS09650"
                     /locus_tag="HHX31_RS09650"
                     /protein_end="78"
                     /protein_start="4"
                     /score="41.7"
                     /tool="antismash"
                     /translation="RLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVIPYLDGRHTV
                     MDIVQALAGELSPAQAVLAVRRYEAAGHL"
     aSDomain        10013..10294
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX31_RS09650_Goadsporin_CD_RRE.1"
                     /evalue="9.20E-14"
                     /identifier="RREFam013.1"
                     /label="HHX31_RS09650"
                     /locus_tag="HHX31_RS09650"
                     /protein_end="98"
                     /protein_start="4"
                     /score="42.3"
                     /tool="antismash"
                     /translation="RLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVIPYLDGRHTV
                     MDIVQALAGELSPAQAVLAVRRYEAAGHLVEGRPPLTDPLLAFWDAQGI"
     gene            12285..13745
                     /locus_tag="HHX31_RS09655"
     CDS             12285..13745
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.5"
                     /locus_tag="HHX31_RS09655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_169947366.1"
                     /sec_met_domain="PF00881 (E-value: 3e-17, bitscore: 58.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTVQLRLRRDAGLSEPEGTPGALTLATPFGPAALRGLPPGAVAA
                     LRALAGGGVSEEELAGIVTSHDGEGGLLRWHLLLRKLSAGALLERAVTSSGGDPVAVLR
                     PYGGGPLRAAAPLAADARVRLSRFAVAAPEDGRLVVRAPRSPLGVELAPAAAPLLGLLA
                     DWTTPAALVCPGLPDATTAAVLGLFAGAGLLVRPTQEGKDPERGAAPLAQWSPADLWLH
                     TRTREPRASARYGGSYPMRGVQDPLPVTPPAFPGPRITLEPPDLDAIAKTEAGLTDVLE
                     ARRSIREHDAAAPITLDRLGELLYRTMRQRGTFTGEDGQELADRPYPSGGAVHELEVYP
                     LVVSCEGLEAGLWHYAAGAHALERVADPGPATRTLLDRARSAAMMTDDPQVLLLVTARF
                     GRVMWKYETIAYSLILKHVGVLYQTFYLVATAMGLAVCGLGGGDAAEFAAASGLDPHAE
                     GSVGELVLGSRPGGAAGTPPQWRTGVPM"
     gene            13742..14554
                     /locus_tag="HHX31_RS09660"
     CDS             13742..14554
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024829.5"
                     /locus_tag="HHX31_RS09660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_169947368.1"
                     /transl_table=11
                     /translation="MKFRLKALQRMREPDELDSPTLLASPRGWIATFVVLIVVVAAGAW
                     SFVGRLPVTVTAKGLLTRPAGTAELQSPYTGTVRTMMVGPGGRVVRGQAVAEVLRADGT
                     VRTVSSPFTGEVVTMSAGEGAMVREGEGLLAMERTDGPHDRLVAMLFVPGDQALGIAPG
                     RTVDLAVADAPPGVFGLLRGTVTSISPYPLMAEGVAGLVGGDLAARGYVGGQPPRLVVV
                     DLVPDAATLSGYSWTTETGPPMRLRSQVTVTGTVTLSSQTPFNLLLGR"
     gene            14566..16818
                     /locus_tag="HHX31_RS09665"
     CDS             14566..16818
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR03796.1"
                     /locus_tag="HHX31_RS09665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_169947370.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.3e-35, bitscore:
                     115.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQVTAPRADAQPPRAPRGRDARRRGGRRGSTPTVIQMEAVECGA
                     AALSMVLGHYGRFVPLEELRAACAVSRDGAKASSVIAAARRYGLEAKGFQMELDDLRDV
                     AKPAIIFWAFQHFMVVEGIRTRFGRQVVAVNDPASGPRLLDWDEFDSGFTGIVLTFEPG
                     PGFRPGGRPTRVAEALLSRRMPTGRALPLVLLASLLLVVPGIVAPAFSRVFIDHILTGR
                     DPGFVLPLLLAMSMTALAMFVLTSVQRHYLLRMEIRMGLVSSARFFRHLLRLPVEFFLQ
                     RRPAEVARRVSANDMVAEILSRDLAITVVNLVLVLFYAVVLVRYDLLLALIGVSMALLN
                     IVVLRQVSRARTDAVAALRADLGNLTSATFNTLQLVETVKATGAEPGAFQRWAGFLAKA
                     VTARQRLGVPSAVITVVPPLLAGVNSGLILLVGGLRVVDGAVSVGLLVAFQSLLGALSR
                     PVTQLTNLGGRLQDISADITRLYDVERHPRSPVFDREDRPSGSRLDGSITFDEVTFGYN
                     PLAKPVISNVSFSVVPGRRVAIVGSSGSGKSTIGRLAAGLYGPASGRVLLDGRDRQEIS
                     RTELAASIAYVDQDISLFEGTVRDNLTLWSDDISDEVVTAALHDAAVFDVISARPGGLN
                     SRVREGGRNFSGGQRQRMELARALAAQPTLLVLDEATSALDPETERVIADNLRRRGCAC
                     LIIAHRLSTVRDADEILVLHQGEVVERGIHEDLVGLGGHYARLIENARTGGEGADR"
     gene            16815..19790
                     /locus_tag="HHX31_RS09670"
     CDS             16815..19790
                     /GO_function="GO:0015440 - ABC-type peptide transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR03797.1"
                     /locus_tag="HHX31_RS09670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP bacteriocin export ABC transporter
                     permease/ATPase subunit"
                     /protein_id="WP_169947372.1"
                     /transl_table=11
                     /translation="MSVSTVADSPAFSSFFTDAATPVDYSADRLLVLADLREVLLVERG
                     AVDLFAVRLRDGKPVGRWNYLCRVRQGTLMLGSPRGPRHSIVGRPVLGTRVSRLPLARL
                     EGLSARRVHGPSESGRAVRALPTREYGLAVREFVRGLDAGLVALAASMRDTLPPRDFVP
                     LVPHEPVTVREGEAVRSVDGVQWITVEDGVVEMPEGVSGQLSAGAEVCVTERDWLAALG
                     PARLRARSTLDLLGEGALWHRWVEHTTRFLYMIDRRVERRNSAELKALTGRAERGADVL
                     RGTARGFDTLVRDTEARVRLADVAGDPPALAAARLVASHAGFPVTAPPQGGAHGGRIDP
                     LQAIALASGVRTRRIRLDDRWWRRDIGPMVGYRASDGVPVALLPIGSRYVVAAPGEERV
                     TPVTAEVAGTLTRHADVLYEPLPPAVTGVGGLLRFGLAKNRKDLWTLLSLGTLVAFIGL
                     LVPAMTGLVLGTYVARAEREMIVQGALLVIAGSLVAAALSVVQNFAALRIEGRSSARLQ
                     AGAWMRLLSLPAKFFTDYSTAELGTTVLGVSAVQETLSGVMTTAALGLFAGLANLVLVF
                     FYDVRLALIASALVLIGVLVCAVAGFFEVRLQRRLYTHEQRLSSRVFQLLTAVPKLRVA
                     AAEDRAFGVWSSEFLKARSVGVSARRVQNFVTTFNAGFTLVASVVVFAVVAGPMLGEVT
                     VPAFLAFFAAFNLLLASVLQFTGAAITAMSVVPMLERLRPILAAEPEEHAGKADPGELS
                     GRIELSRTSFRYGEDGPLVLDEVDVSIEPGEFVAIVGPTGSGKSTILRLLLGFESPSSG
                     TVLYDGQDLDELDIGAVRRQCGVVLQNSSLLAGDIKTNIIGSTDHTIDDAWDAAAMAGI
                     ADDIANMPMGMHTVLSEGTNTLSGGQRQRIMIARALVSHPRIVLFDEATSALDNPTQKV
                     VTESTRQLNATRIVIAHRLSTIRDADRIVVLDRGRIVQQGRYQELLEDADGLFARLARR
                     QI"
     gene            complement(19839..20024)
                     /locus_tag="HHX31_RS09675"
     CDS             complement(19839..20024)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS09675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169947374.1"
                     /transl_table=11
                     /translation="MTPFWKIFIAIFCYISALVGLGLAVANASVKPPATTHAFVYGALG
                     VVFLVVAIAMSRKPRY"
     gene            complement(20021..20857)
                     /locus_tag="HHX31_RS09680"
     CDS             complement(20021..20857)
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="HHX31_RS09680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_169947376.1"
                     /transl_table=11
                     /translation="MSAATGAGSYDPATTTAGGLSGELARLEAQAALSFDEELRVLLDV
                     GVPAPLLELGAGSGAVTRRLRAALPDLPVVAADIDTALLAHAADARVPLIGCDAVRLPL
                     ADGAVGTVLLRYVLQHVADPAAVVAEALRVLRPGGRLVVVEVDSMLWGLADPMYPELAG
                     VHGRMAGAQREAGGDRLIGRKLTRILRRAGFHEVVLRPFATTNDDRPTEAFAPHMGPER
                     LAPLVASGALSLPELALAADRWRRFRADPDAWVMLLGLVVAGTAPGGPAQSERSTP"
     gene            complement(20854..22122)
                     /locus_tag="HHX31_RS09685"
     CDS             complement(20854..22122)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="HHX31_RS09685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_169947378.1"
                     /sec_met_domain="p450 (E-value: 9.4e-80, bitscore: 263.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREAPLRFVTEMAAYGDVTRHETETGPVYMLHRPDLARHVLKDNG
                     ANYTKDRTPDDDMLRPLLGNGLLTSGGEDWARQRKMIAPAFRPTEVERFDEIMTDAAAG
                     LAERWRRAGEEGAAVRVDHELTSLTLTVIARAMLGTDIAGVGDGFGRAVDEVNRFIGHF
                     DPASEKGGREGFRRAKAFLDGVTRAIVAARRATGQEGDDLLGAMLASGHAMTATELRDQ
                     VLTIVMAGHETTAKALTWTLYLLDRHPDAARAVRAEVDEVLGDDRAATAADMPRLTACQ
                     RAIKEAMRLYPPVWLISRRSVEADIVGGYPIPPGTLVCVSPYVLHRDPRYWHDPETYAP
                     DRFLAEHTHAGHQYLPFGGGPRVCVGRHFAMVEATLVLAVLLRAVRPELVPGFPVEPEA
                     LVTLRPRHGMLMVPRPRQAGSRP"
     misc_feature    complement(22212..22225)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.87"
                     /tool="antismash"
     misc_feature    complement(22219..22233)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.75"
                     /tool="antismash"
     misc_feature    complement(22399..22414)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            22422..22814
                     /locus_tag="HHX31_RS09690"
     CDS             22422..22814
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX31_RS09690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_211589541.1"
                     /transl_table=11
                     /translation="MSLDPRQRAEFVNAYTRVLITAWSSEEYSARLDSDPRSALAESGL
                     ELPAGAEVTLVRNIPEGHHDSNIEVQVALWERGLETGRFELHIPETPQVDMAELSEGDL
                     DSIAAGASAVEAIDINCCCCPCCCCT"
     misc_feature    complement(23194..23208)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 gtaccagtcc atcgagaacc ggctcttgtc ggcgaacgcc tccgggtggt cggcgatcac
       61 gtggccgagc cggtcggcgg cgagttccca gtcgggctgc gggtcgttca gccgttcggc
      121 gagcagcgca ccgcaccgca ggccctggta gatcgacgac gacccggtga gcagggcgta
      181 ctccgccggc cggccctccg cgtcgcgctg ccacagcacc tcgccgcgcg cggtctgcag
      241 gccgacgacg aagtcgagcg cccgggtcac cgcaggccac atcgaccggg cgaagtcgtc
      301 gtcgccggtc accagcaggt cgtgccagac gcccaccgcg atgtacgccg cgtggttgga
      361 ctcgccggcc gcctcggcgg gctcgccgtc gcggaccttc atgggccagg agccgtccgg
      421 gcgctggtgc cgtacgagcc agtcgtagcc cttgcgggct tcggcgcgca gcccggccac
      481 ggtcagcgcc atcaggcact cgatgtggtt ccacgcgtcg atgtggccct caggccaggg
      541 cacgccgccc tggtcgtcct ggatcgcggc gatgctctcg gccgtacgga cgacctgctc
      601 ggcggtgatg atccctggga cgtcgggtaa ccgcctcatg ccggcttccg gacgtagacc
      661 acgacgctct tgccgatcag ggggttgagc acggcctcgg ccagccgcgt ggcgaggggg
      721 cgcttcatga tgtcccagac gagcagttcg tggtacgcct tggccagagg gtgaccgtcg
      781 tcgttcaccc cgactgcgca cttgatccac cagtagggcg agtgcaggcc gtgggcgtag
      841 tggtggccgc cgacctcgag cccggaggac ttcagcttcg cctggagttc cgccaacgta
      901 taaatccgga tatgtccgcc gggggccgtg tggtagtcct ccgacagggc ccagcagatc
      961 cgctcgggca ggaagctcgg caccgtgatc gcggcccggc cgcccggctt cagcacgcgt
     1021 acgatctcgc gcatcgcggc catgtcgtcg gggatgtgct ccagcacctc cgcggcgatg
     1081 acgcggtcga acaacgcgtc ggggaacggc atgccgaggg cgtcgccgac cacggtctcg
     1141 ccggtcgcgc ccgccggcac ctcgccctcc ttgtccatgg ccgcgaacat ggccgccacg
     1201 ctctccatct cggcggcgtc catgtcgaag gcgaccacgt cggcgccacg gcgcagcacc
     1261 tcgaaggcgt gccggccacc accggccccg aggtcgagga cacggtcgcc cggtccgacg
     1321 ggcagccggt tgaagtcgac ggtcagcact cgctgcctgc ctttcgtggg ttctggggag
     1381 tcaccgtttc cgggcggtca ccgcgagcgg gtgtgggcgg cgatggcctc gtggtaggcc
     1441 tcgaccgtgc gccgcgcgac caccggccac gcgtagcgct ccatgacgcg ctcgtagccg
     1501 cggcggccga actcggcgcg ctcggcgggg gagtcgagca ggcggcgcag cacaccggca
     1561 agctcctcgg cgtcgcccgg cgtcacctgc acggccgcgt cgccgaccac ctcgggcagc
     1621 gcgcccgtac gcgaggcgac cagcggcgtg ccgcacgcca tgtgctcgac ggccggcagc
     1681 gagaacccct cgtacagcga ggggaccacc gcgacctcgg aggtggcgat cagctcggcc
     1741 agctcctcgt cggggatgcc gtgcacgaac cgtacgcggt cgtgcagcga cagctcgctg
     1801 acgagctgct cggtgggccc tccgggggtg ggcctgctca cgaccgtcag gttgacctcg
     1861 cgctcggtgg cgagcttggc gaccgcgcgc agcagggtcg ccacgccctt catgggcgag
     1921 tcggcgctcg ccacggccac gatcgagttg tcccgcttcg gcagttccgg ccgggggtgg
     1981 aagaaccgcg tgtcgacgcc gagcgggatc agccgcatgc tggactgcgg cacgttgaag
     2041 tcgcggtgga tgtcggccag cgacgactcg ctgaccgtca ggatcgggct gagccggggc
     2101 gccacgacgc tctgcatgcg cacgaagccg taccagcggc gcatcgacag ccgcttccag
     2161 cccttggcgg ccttcagctc gatccgccgg tccacgctga tggggtggtg gatcgtgccg
     2221 accaccggga acagcctctt gatgccgagc aggccgtagc ccagcgtctg gttgtcctgg
     2281 acgacgtcga agtcgccgcg ccgcgccttc agctcacggt aggcccgcag gctgaacgtc
     2341 agcggctcgg ggaagccggc cgtccacatc gtggcgacct cgagcgcgtc gatccagtcg
     2401 cggtattcgt cgcgcttcgg tgtgcggaac gggtcctcgt cgcggtagag gtccaggctc
     2461 ggcaccttgt tgaggatcac accctcgtcc agctccgggt acggctggcc ggagaagacc
     2521 tcgacgtggt ggccaagagc gacgagctcg cggctgatgt ggcgtaggta caccccctgg
     2581 ccgccgcagg tgggcttgct gcggtaggac agcagcgcga ctcgcagcct ctccgccaag
     2641 aggcacccct ttccagccgg tttcccgccg tgcccccgtg gggctgctgc caggaacact
     2701 accatttgac cttagatggg gtaggtgagg tggaaagggt cctcgatcga ccttcacccc
     2761 tcccgacctg gggcgttagg ttacccgaac gacgttcggt gtaacgtgtt ctagctttgt
     2821 tctgactggc ggatgcgtgg gccgggcagg gcagggcggt acattcgcct ctcataggcc
     2881 atgttgggcg ctacgaggag gatccgttgg ccaggcgtgc gctgatcacc ggcatcaccg
     2941 gtcaggacgg ctcctatctc gcggaacacc tgctgagcga gggatacgag gtctggggcc
     3001 tggtcagggg gcaggccaac ccgcgcgtcc cccgcgtgcg ccggctcctc caggacgtgc
     3061 ggctggtccg cggcgacctg ctcgaccagg gatcgctgat ctcggccgtg gagaaggcgc
     3121 agccggacga ggtctacaac ctcggggcca tctcgttcgt gcccatgtcg tgggagcagg
     3181 ccgagctcac cggcgaggtg accggcatgg gcgtgctccg cgtgctcgag gccatccgcg
     3241 tctgctcggg catcaccgcc tcgcgcgggt cggcgaccgg gcagatccgc ttctaccagg
     3301 cgtcgtcctc cgagatgttc ggccaggtca gggagacgcc gcagaccgag cgcaccccct
     3361 tccaccccag gtcgccgtac ggcgtggcca aggcgtacgg gcacttcctc acgcagaact
     3421 accgcgagtc gtacgggatg ttcgcggtgt cggggatcct gttcaaccac gagtcgccac
     3481 ggcggggggc cgagttcgtc acccgcaagg tctcgctcgg cgtcgcgcgg atcaagctcg
     3541 gcatggccgc cgaactgcgc cttggcaacc tcggggcgcg gcgcgactgg gggttcgccg
     3601 gcgacttcgt ccgcgccatg cacatgatgc tgtcggccgc cgagcccgag gactacgtca
     3661 tcggcaccgg gcgcacccac tcggtgcggg aactggtcga ggcggcgttc gccgcggccg
     3721 acctggactg ggagcggtac gtcgtctgtg acgcggccct gcaccgtccc gcggaggtcg
     3781 acctgctgtg cgcggatccc aagaaggccc gcacacagct cggctgggag ccgacggtgt
     3841 cgttcgagga actcgtggcg atgatggtcg aggccgacct gcgcctcctc gccgacggcg
     3901 gcgacccaga tggcgtgatc ttgtagtttg tcgcacgggt ggggtccgac ctgggcgtcc
     3961 acccttcgtg atcatgcact tttcgtgcac cacgccgccg acctgcgcct ttcgtgtccg
     4021 tgatcttgca ctgcatatgg gcatggctgg tcccgcgtac ggctcggccg tacgcgggtc
     4081 cgactctcag gtcatatggg gatcaacgcg ccctatgccg cgtaccgccg atggcgcgcc
     4141 tccgggctgc cgagcaggcg aagctggcgc tgcaggcgta ccgactcttc cggcgtgggc
     4201 cgccagccgg cctcccataa ccgctcggcg acgcgttcga ggaaggtcgc ggggctgccg
     4261 aacagctcgt ccttcctgat gatcaccagc cgccacccaa gccggcggat ctccgctcgt
     4321 ctccactcgt catgcgccct gtcctgggcg ctgctgtggt ggtcgtggcc gtcgtactcg
     4381 atgccgaccc gatatcgctc gatccccatg tccaggtagg ccaccctttc gcccggcagt
     4441 tcgacgcgga cctgcgaccg cggccggggc agcccggcat cgacgacgag aaccctgacc
     4501 cagctctcgg gcgggctctg cgcaccagcg tcgccgagtg cgacgacctc acgcaggcgt
     4561 ttcgcgttcc gccggccggc gagctccgcc gctcgcccgc gcagccgctc ctccggcact
     4621 ccgcgcgcga ggaactggtc gagcgccgcg accgcctcca ggcgcggcag ccaccgggcg
     4681 cagtcgaggg ccgtacgctc ctgcgtcgtc accgtgactc cgccgatcga ggtcacgtcg
     4741 ccgggcggca gccggtcgct ctgccgtccg acgacgtacg cccgtcgcgg cggcgtacgg
     4801 ccgccgctcg gcacgacgac ctcgacgggc cactcgtcgt gccgtttccc gggaggcagc
     4861 acgtcgagcc cccagagcca ggcggccgtc ctgcggcagg cgacgacgtc ccgggaggtg
     4921 atgccgagcg cgtgcgcgcg tacggcgagg gcgcgcgggt cggggccggc gtaaaggccg
     4981 ccacgggtga cgcgccagaa cctgccggtg gacacgagcc gcgacgtgtc gctgcggctc
     5041 aggccgtacg cggaggcgag cggcgacgaa aggtactcct ccatggctca gatcgtgcgg
     5101 catcgcgccg cgtctccgtc gccggtgcgc cggtcctgtg gataacccac tgcttgatcg
     5161 cgtacgggat cggcgcaggt ggtggggggt aggcgggaag gacgtgcaag atcacggagg
     5221 agggaggcgc aggtgggcac ggtcgcgtgc gacaaactgc aagatcacca acggtgaagt
     5281 ggcaggtcgg gggagtgtcg tgcgacaaac tgcaagatca cggccggtga ggggctgctc
     5341 accggccatc tctgcgacta attacatgat cacgggaggg gggtgggggt gacggggagg
     5401 gatttgatgc cgttgatgaa gttcgacctc aggcgtctgg cctcgccggc ctggctgagg
     5461 ccgggcaggc gctgggccag cacctcgaac agcaccctca gctccagctt ggccaggtgg
     5521 ttgccgaggc agaagtgcgc gccgccgccg ccgaacccga tctgggggtt gggatcgcgg
     5581 ccgatgtcga actcgtcggg ccgctcgaac acctccgcgt cacggttggc cgacgagtag
     5641 aagaccacga ccttgtcgcc cgcggcgatc ttctgcccgc gtatctcggt gtccgcggtg
     5701 gccgtacgcc ggaacatgtt gaccggcgac acccagcgga cgatctcgtc ggcggccgtc
     5761 gcggcgaggg aggggtcgtc gaccaggcgc ttccactggt ccgggtgctc gaagagggtc
     5821 agcatgccgc cggacgccgc gttccttgtg gtctcgttgc ccgccacgat gagcagcagg
     5881 acgaacaggt cgaactcgtc ccgggtcagg gtctgcccgt cctcgtcggg ccgcagcagc
     5941 ctcgtgacga tgtcgtcgcg gggttcccgc ctgcgcgcct cgcccagggc gtgggcgtac
     6001 gagtagacct cgagggcggc ggcacgcccc tcctccgggc cctcggcgta gtcggggtcg
     6061 tcgttgccga tcatgcggtt ggaccactcg aagatctttt cccggtcctc gaccggcgcg
     6121 ccgagcagtt cgcagatcac gtacagcggg agcggagcgg cgatgtcccg cacgaagtcg
     6181 acctcgggct cgccctggac ctcgtccacc agcgcgtggc agatgtcccg gatgtgctcc
     6241 tcaagccgtc cgatctggcg cggggtgaaa ccgcggttga ccagcgagcg gcgcctggtg
     6301 tggtcgggcg ggtcctggtt gagcatcatg aggcgctgga actcgcgctg ctcctcgggc
     6361 atctcgtcga acagcgccag cttcctcgcg gaggagaaca ggtcggagtg ccgtgaaacg
     6421 tggacgacgt cggcgtgctt ggtgatcgcc cagaagtcgg gccagccgtc ctgcccctcg
     6481 tgccagtaga cgggcgtgct ctccctgagc aggcggaact gctcgtgcgg gaccccgccg
     6541 cgcgcgtaac ggtccttgtc gacgaggtcg atttccatgg tgtccaccca atcgcgttcg
     6601 gcggcccctg atgggagggg cggtcgccct gtcggtgccc tgcggtgatg cggtccacgc
     6661 gtaatccacc cgaatcgact ccgacgtccg gtcaagtggc cggtcaggcg accgggcgtc
     6721 cgccgctact cctcctgacc gggccatcgg cgggtttcgg tctgccgttc gcgcagccgg
     6781 ttgatggtct cggccagctc ggcacgggtg tggatgccga gcttgcggta gatccgggct
     6841 agatgggtgt ccacggttcg cttgctgatg gacagctcgg tggcgacctg gaggttgctc
     6901 atgccgcgca gaaccaggtc cgtgacccgc atctccccgg cggtcagcgg cgaagggcca
     6961 ccggcgggcc cgccgcgggg ccgcccgccg acgccggcga ggttgcgctc cgcgagcgcg
     7021 gcgagtcgca cggcgccgcg gccgtcggcg agcgcgtgcg cctcgctgag cgtgtcgtgg
     7081 gcccggcgcg cgtccccgga ggcccgcagc gcgacgccca ggcgcaccat cgcccggacg
     7141 cgctcgattc cgccctcggt cccgtccagc acggtcagcg cctcgacgag caggtcgacc
     7201 cggcgaccgc cctcgacggt cgcgctcatg gtgctcagcg cgcggccgat gccgtacggc
     7261 gcgccccagg ccctggccag ctccagctcc tcctcggcca ggcggcgggc ggccacccgc
     7321 tggccgagcc gcagataggc gagggcggcc tggccgcgcc agcccccgca ggccgggttg
     7381 accactccgg cggacagcaa ctgccggccg gcctccagca gggcccgcag cccctcgcgt
     7441 acgtcgcccc tggcgaccgc gacccggccc tgggcctcca gcagggctcc gtgcaggaat
     7501 ggatgcaccg gctcgcgcgc ggcgacctcg tcgaacagcg cgtgcgcgac gtcgagctcg
     7561 tcgcgctcca ggagcacgcg ggccgcgcag gacacggcgg cggcgtgcag cccgagggcg
     7621 tgcgatcccc gcgcgaacag gatggcctcg cgcgcgtgcg cgagcgacgc gcgcagctcc
     7681 cccctgcggt aggcgatgtc cgacagcagc gtgacggcga gtgcctgccc ggtcgtcgag
     7741 gcgttcgccc gcgcgtctgc ggccacctgc tccgaccagt acgccgcctc gtccacgcgg
     7801 cccgcccaca gcagcgcgac gaccagtgtc ggcgggatcg gcccgccccc gtcgaggcag
     7861 cgccgggcga gggccagtgt gcgctcgcgg tgcctgcctc tggccgcgca ggacagcgcg
     7921 gcggtggcga gatagtcctg cgctccggct cctgcccccg actcggcgcc gagcagccgc
     7981 atcgccgcgc gcgagccgta cgactgaccg gtgagcagcg cctgcgcgct gagccgcagc
     8041 agcgcctcgc ggcggtcggc gagccggccg gccgggtcgt cgtcgaaacc ccgggcgatg
     8101 tcgcagaagg ccgaggcggc ctccggggag ttgagcgtga gcagggtggt ggcgaagggc
     8161 gacagggagt cggcccgctc gccgacgtcg ccggcgagca cggtcacggc gcgcaggtgc
     8221 cgcaggcagg cggggatgtc gaggtgcatc tcgacggcgc ccagctccgc ggtcacctgg
     8281 aggatggccg ggcccttggc cgtggcgagc gcccggtgga ggtagcgggt cgcgtcctcc
     8341 caggcgttct ccgagaccgc ctcccgggcg gcctcgcgga gcaccgacac ggcccacggg
     8401 tcgccggtgg ggctggccga cagcaggtgc cgggccggcc gcttgggcgg cgagccgagg
     8461 cggtgcagca gcgaggccgc ccgccggtgc atctcgtcgc gtgcgcgggg atccatccgc
     8521 gcgaggatcg tcgactggac gaggtcgtgg gtgaaccgct gcggcgggct gccctccagc
     8581 aggccggccc ccgcgagcgc ctgtcccgcc tcctccgccg cgaccgcgcc gtacccggcc
     8641 agcatcgccg ccgtctccag ccctgcgtac ggcgcgatga tggcgaggct ctgcaggagc
     8701 gtgaggaggg acggatacct gccggcgacc cattcgagca cggtctccga gagcgcgatg
     8761 gcgccgatcc gcagcaccct gggcagctcc gcgcgttccg gcaggacgtc ggcggcggcc
     8821 agccgcgccg ccgtctccag caggagcagg gggttgccct tggtgaggtc gtgacaggcg
     8881 gcgacgatct cgtcgtccac ggaggcgccc agcaccgacc cgatgagcgt ggcggcgcag
     8941 ttccggcaga gcggggaggg cctcagtgac cgcgcgtacg gcagtgtcag gatgtccctg
     9001 accgtctcgc ccgcggtgcg gtcctccgcg tcgcaggtca ggatcatcgc gatgggcagg
     9061 ccgtcgagcc gcctggcgat gtaggagcac cactgcgccg actgggggtc ggcatggttg
     9121 aggtcgtcga cggcgatgat gagcggctgt ccggcggtca gcgagcgggt ggcccggtag
     9181 aggtcgtcga gcagcgtggc gggcacgcct ggcgcgctcc cgtcgtacgg cacggccgtc
     9241 atggcgggcg cgtgggcgtt cgcgtcgagc acggcggcgg gggcgccggc ctccgcccgg
     9301 cccgcgccgc tcatcatcgg gtcgaacaac tggcggacga cgccgaacgc gaaggagcgc
     9361 tcgtcggcgt ggccccgggc gctgaggacc accccgcccg gcctgcgtgc cagcgccgcg
     9421 tgcagcaacc gggtctttcc gcttccccgg gtgccctgga tcaccagtac ggccggccgc
     9481 ccatcggaaa ggccggccag catgtcgtcg acgacatcca gctccttgtc acggtgcagt
     9541 agtaccggcc gccctgaggc catccctacc cccggaccac atgcttattt tcttgacata
     9601 cggatcatgc cggacagggt cggcagtctg tcaatacgtg aattccagtc gagttaaagc
     9661 gccactatcg ccgacaagta acagtcggat tctgtcatga ttccaagtcc gacgactcgg
     9721 gtgtatcacc cgcccgagcc cggaacccct acgccatagg cgattcgggc ggccgaatcg
     9781 ccgcgcgggc ccgccggccg ggtgcccgcc gccccgcatg gcatacgtat tcggccgcgc
     9841 ggcccgcgct acgcatcgcc gtacgcaccg attcggattc cgagctgtgc gggagatgcg
     9901 tacgtatatg tcagtagggc aataaatacg tctttacttc ttcatgaatt cggtggaatt
     9961 ctccgctcat cggctaatcg accagtgaat ggcgaggggc atggaacggc cacggctgaa
    10021 ggcgcacttc accaccgaag tcctcgacga cgcgaaagtc ttccttctgg cggagggcca
    10081 gcactatctc gtccgcggcg cgggctcggg ccgcgtcatc ccctatctcg acggccggca
    10141 caccgtgatg gacatcgtgc aggcgctggc cggcgaactg tcaccggccc aggcggtgct
    10201 cgccgtacgg cgctacgagg ccgcgggtca cctggtcgag ggcaggccgc ccctgaccga
    10261 cccgctgctc gccttctggg acgcgcaggg catcgacccg gcggccgtcg tcaccgccct
    10321 ggagcggacc tccttccgcg tgttcgcggg cagtggcgtc gacccggcgc cggtcgaggc
    10381 gctgctgcgc gagcacgggc tgcgtacgga tccgcacgac ggcggcatgg gcgacatggt
    10441 cgtggcggtg gtcgacgact acctggaccc gggcctcgag gagctcaacg ccgagtgcct
    10501 ggcggccggg cggccctggg tgctggtcag gccggccgga accgtggcct ggctcgggcc
    10561 gctgttccag ccgggggaca cgggctgctg ggcctgcctg tcccagcggc tcgcgggcaa
    10621 ccggcaggtc gagcgttacc tggcgggcaa gcgcggccgc ggggaagcgc cgagccaccc
    10681 ggtgcgcgag gcgctgccgg gcggcgtggc cgcggtcggc gggctgctcg cggccgagct
    10741 cgtgcggacc gccgccaccg gcaagccgtc gacgctgcag ggcaccatga tcacagtgga
    10801 cctgcgcacg ctcaccagcg cggagcacca gctgatccgg ctgccgcagt gcccggcgtg
    10861 cggcgacccc gcgctgatcc gtgagcggga gcccaaggtg gcgctggccg cgcggaccgc
    10921 caggcacgtg accgacggcg gctaccgggt cgagcagccc tcggcgacgt acgcccggct
    10981 ggagcggcac gtcagccctt atctcggcgc ggtcaccggg ctgcgcccgt ggaacggcga
    11041 ggacaacggc gtgacctaca gcttcaccgc tggtcacaac ttcgcgatgc tcggcgacaa
    11101 catggacctg ctgcgccgca acctgcgcgg gcagagcggc ggcaagggcc gcaccgagat
    11161 ccaggccaag gtcagcgcgc tgtgcgaggc gatcgagcgc tactcgggcg tgtggcgcgg
    11221 cgaggagccg gtgctcaagg cggcctacgc cgacatcgag cagggccgcg cggtccaccc
    11281 ggacgatctg ctgctgttct cggaaaggca gttcggcgac aggtccgcct ggaacagcga
    11341 cccctcgcac cggctgcacc tggtgcctga gcggttccgc accgacctgc cgctggactg
    11401 gtcgcgggcc tggtcgctga ccgcggacga ggagcggctg gtccccgccg ggtacgcctg
    11461 gtacggccac cccgacctgg aacgccactt ctactgtgtc ggcgactcca acggcagcgc
    11521 atcgggcaac acgctcgagg aggccatcct gcaggggttc tgcgaggtgg tggagcggga
    11581 cgcggtcgcg ctgtggtggt acaaccgggt ccgcaggccc gccttcgacc tcgactcgct
    11641 caacgagccc tacatcgaca cgctgcgcga gttctacgcc gacatgggcc gcagcctgtg
    11701 gctgctcgac ctcaccaccg acctcggcgt gccggccttc gccggcgtgt cccaccggct
    11761 ggaccacccc gtgcaggacg tcatcgtggg gttcggctca cacctcgatc cccggatcgc
    11821 cgcgctgcgc acgctgaccg aggtcaacca gttcctcccc tccgtacgcc gcagggacga
    11881 gaacggcgag acgatctacc acgacgacga catcgccacg ctccgctggt ggaaggagac
    11941 caccgtcgag agcgacccct ggctgctgcc cgaccccgcg cagcgtccgc gcacgctcgc
    12001 ggactacgcg gtgccgcagg acaccgacct cgcggccgac gtcgagacct gcgtctccag
    12061 ggccgccgcc tgcggcctgg agatgatcgt gctcgaccag accaggcccg atcttgagct
    12121 cagcgtggcc cgggtgctgg ttcccggcat gcgccacttc tggcgcaggc tcggccccgg
    12181 ccgtctgtac gacgtcccgg tgtccctcgg ctggcggacg cggccggcca cggaggagga
    12241 gctcaacccc accagcgtct tcttctgacc gataggggag agcgatgcac accgttcagc
    12301 tgcggctgcg ccgcgacgcg gggctgtcag aaccggaggg gacgccgggg gcgctcaccc
    12361 tggccacgcc gttcgggccg gccgcgctgc gcggtctgcc gccgggcgcg gtcgccgcgc
    12421 tgcgggcgct cgcgggcggc ggcgtgagcg aggaggaact ggccgggatc gtcacctcgc
    12481 acgacggcga gggcgggctg ctgcgctggc acctgctgct gcgcaagctg tcggcggggg
    12541 cgctgctgga gcgggcggtg acgtcgtcag gcggtgaccc ggtcgccgtg ctgcgcccct
    12601 acggcggcgg tcccctgcgc gcggccgcgc cgctcgccgc ggacgccagg gtgcgtcttt
    12661 cgaggttcgc cgtcgcggcg ccggaggacg gcaggctcgt ggtgcgcgcg ccccgcagtc
    12721 cactcggggt ggagctcgcc ccggccgccg ccccgctgct cggcctgctc gcggactgga
    12781 cgacgccggc cgcgctcgtc tgccctggcc tgccggacgc gaccacggcg gcggtcctcg
    12841 gcctgttcgc cggcgccggg ctgctggtgc ggccgacgca ggaggggaag gaccccgagc
    12901 gcggcgcggc gccgctcgcc cagtggtcgc cggccgacct gtggctgcac acccgcacca
    12961 gggagccacg cgcgagcgca cgctacggcg gcagctaccc catgcggggc gtgcaggatc
    13021 cgctgcccgt gacgccgccc gcgttccccg ggcccaggat caccctggag cctcccgacc
    13081 tggacgcgat cgcgaagacc gaggccggtc taaccgacgt cctggaggcc cgccgctcga
    13141 tccgcgagca cgacgccgcc gccccgatca ccctggaccg cctcggcgag ctgctctacc
    13201 gcacgatgcg ccagcggggc acgttcaccg gtgaggacgg ccaggagctg gccgaccggc
    13261 cctacccgtc cggaggcgcc gtccacgagc tggaggtcta tcccctcgtc gtctcctgcg
    13321 agggcctgga ggcggggctg tggcactacg ccgccggcgc gcacgcgctg gaacgggtgg
    13381 ccgatcccgg tcccgcgacc cgcacgctgc tcgaccgggc caggtcggcg gcgatgatga
    13441 ccgacgaccc ccaggtcctg ctgctcgtga cggcccgctt cggccgggtg atgtggaagt
    13501 acgagaccat cgcctactcg ctgatcctca agcacgtcgg cgtgctgtac cagaccttct
    13561 acctggtggc cacggccatg ggcctggcgg tctgcgggct cggcggcggg gacgcggcgg
    13621 agttcgccgc ggccagcggc ctcgacccgc acgcggaggg cagcgtgggc gagctcgtgc
    13681 tcggcagcag gccgggcggc gcggcgggga cgccgccgca gtggcggacg ggggtgccga
    13741 tgtgaagttc cggttgaagg ccctgcagcg gatgcgggag cccgacgagc tcgactcgcc
    13801 gacgctgctc gcctcgccgc gcggctggat cgccacgttc gtcgtgctga tcgtggtcgt
    13861 cgccgcgggg gcgtggtcgt tcgtcggccg gttgcccgtc accgtcaccg ccaaggggtt
    13921 gctgacccgc ccggcgggca ccgccgagtt gcagagcccc tacacaggga ccgtgcggac
    13981 gatgatggtg ggcccgggcg ggcgggtggt gcgcggccag gcggtggcgg aggtcctgcg
    14041 ggccgacggc accgtgcgta ccgtgagcag cccgttcacc ggcgaggtcg tcaccatgtc
    14101 ggcgggcgag ggcgcgatgg tccgcgaggg cgaggggctg ctcgcgatgg agcggaccga
    14161 cggcccccac gaccgcctgg tcgcgatgct gttcgtgccg ggcgaccagg cgctcggcat
    14221 cgcccccggc cgtacggtcg acctcgcggt ggccgacgcc ccgcccggcg tgttcgggct
    14281 gctgcgcggc acggtgacct cgatcagccc ctacccgctg atggcggagg gcgtcgccgg
    14341 cctggtcggc ggggacctcg cggcccgcgg ctacgtcggc gggcagccgc cccgcctggt
    14401 ggtcgtcgac ctcgtccccg acgcggcgac cctctccggc tactcctgga cgaccgagac
    14461 cggtccaccg atgaggctgc ggtcgcaggt cacggtgacg ggcacggtca cgctcagcag
    14521 ccagacccca ttcaacctgc tgctcggacg ctgagaagga gacggatgag ccaggtcacg
    14581 gcgccccgcg cggacgccca gccgccccgc gccccgcgtg ggcgcgacgc ccgcagacgg
    14641 ggcgggcggc gcgggagcac gccgaccgtc atccagatgg aagccgtcga gtgcggggcg
    14701 gccgccctgt ccatggtcct cggccattac ggcaggttcg tgccgctcga ggagctgcgg
    14761 gccgcctgcg cggtgtcccg cgacggcgcg aaggcgtcca gcgtgatcgc cgccgcccgc
    14821 aggtacggcc tggaggccaa gggcttccag atggagctgg acgacctgcg cgacgtcgcc
    14881 aagccggcga tcatcttctg ggcgttccag cacttcatgg tcgtcgaggg catccgcacc
    14941 cgcttcggca ggcaggtcgt ggcggtcaac gaccccgcga gcggcccgcg cctgctcgac
    15001 tgggacgagt tcgactcggg cttcaccggc atcgtgctga ccttcgagcc agggccgggg
    15061 ttccggccgg gcggccgccc caccagggtc gcggaggcgc tgctgtcgcg ccgcatgccc
    15121 acgggccggg cgctgccgct ggtgctgctg gcgagcctgc tgctggtcgt gccggggatc
    15181 gtcgccccgg ccttcagccg ggtgttcatc gaccacatcc tcaccggccg cgatcccggc
    15241 ttcgtcctgc cgctgctgct ggcgatgtcg atgaccgccc tggcgatgtt cgtgctgacc
    15301 tcggtccagc ggcactacct gctgcggatg gagatacgga tggggctggt cagctccgcc
    15361 cgtttcttcc ggcatctgct gcgcctgccg gtggagttct tcctgcaacg caggcccgcc
    15421 gaggtcgccc ggcgggtttc tgccaacgac atggtcgccg agatcctgtc cagggatctg
    15481 gcgatcaccg tcgtcaacct cgtcctcgtg ctcttctacg cggtcgtcct ggtcaggtac
    15541 gacctgctgc tcgccctcat cggcgtgagc atggcgctgc tcaacatcgt ggtcctgcgg
    15601 caggtgtcga gggcgaggac cgacgcggtg gccgccctgc gggccgatct cggcaacctc
    15661 acctcggcca cgttcaacac gctgcaactc gtggagaccg tcaaggccac cggcgccgag
    15721 ccgggggcgt tccagagatg ggcgggcttc ctggccaagg cggtcaccgc ccggcagcgg
    15781 ctgggcgtgc cgagcgcggt catcacggtc gtgccgccgc tgctcgccgg ggtcaacagc
    15841 gggctcatcc tgctcgtcgg cggcctgcgc gtggtggacg gcgcggtcag cgtcggcctg
    15901 ctggtggcct tccagagcct gctcggcgcg ctgtcgcggc cggtcaccca gctcaccaac
    15961 ctcggcgggc gcctccagga catctcggcc gacatcaccc gcctgtacga cgtggaacgg
    16021 catccccgct cgcccgtctt cgaccgcgag gacaggccct cgggcagccg gctcgacggg
    16081 tcgatcacct tcgacgaggt gacgttcggg tacaacccgc tggccaaacc ggtgatcagc
    16141 aacgtgtcgt tctctgtggt gcccggccgc cgggtggcga tcgtggggag ctcgggaagc
    16201 ggcaagtcga cgatcggcag gctcgcggcc ggtctgtacg gcccggcgtc cggccgggtg
    16261 ctgctcgacg ggcgcgaccg ccaggagatc tcgcgcaccg agctcgcggc ctcgatcgcg
    16321 tacgtggacc aggacatctc actgttcgag ggcacggtgc gcgacaacct cacgctgtgg
    16381 agcgacgaca tctccgacga ggtcgtcacc gccgcgctgc acgacgcggc cgtcttcgac
    16441 gtcatctccg cccgtccggg cgggctcaac agccgggtcc gcgagggcgg gcgcaacttc
    16501 agcggcggcc agcgtcagcg gatggagctg gccagggcgc tggcggcgca gccgaccctg
    16561 ctcgtcctcg acgaggcgac cagcgcgctc gacccggaga ccgagcgggt gatcgccgac
    16621 aacctgcgcc gccgcggctg cgcctgcctg atcatcgcgc accggctgtc caccgtacgg
    16681 gacgccgacg agatcctcgt gctgcaccag ggcgaggtgg tggagcgcgg catacacgag
    16741 gacctggtgg gcctcggcgg gcactacgca cgcctgatcg agaacgcccg gacgggcggc
    16801 gagggagcgg accgatgagc gtctcgaccg tggcggactc cccggcgttc tcgtcgttct
    16861 tcacggacgc ggccacgccg gtcgactact cggccgaccg gctgctcgtg ctcgccgacc
    16921 tgcgcgaggt gctgctggtc gagcgcggcg cggtcgacct gttcgccgtg cgcctgcggg
    16981 acggcaagcc ggtcggcagg tggaactacc tgtgccgggt gcggcagggc acgctgatgc
    17041 tcggctcgcc cagggggccg aggcacagca tcgtcgggcg gccggtgctc ggcacccgcg
    17101 tgtcgcgcct gccgctggcc cggctggagg gcctgtcggc ccggcgcgtc cacggcccgt
    17161 ccgagtcggg cagggcggtc cgcgcgctgc ccacccgcga gtacggcctg gcggtgcgcg
    17221 agttcgtgcg cggcctggac gccgggctgg tggcgctcgc ggcgtcgatg cgcgacacgc
    17281 tgcccccgcg cgacttcgtc ccgctggtgc cgcacgagcc cgtcaccgta cgcgagggcg
    17341 aggccgtccg ttccgtcgac ggcgtccagt ggatcacggt cgaggacggc gtggtcgaga
    17401 tgccggaggg cgtctcaggt cagctcagcg cgggcgccga ggtctgcgtg accgagcgcg
    17461 actggctggc ggcgctcggc ccggcgcggc tgcgcgcccg gtcgaccctc gacctgctcg
    17521 gcgaaggcgc gctgtggcac cggtgggtcg agcacaccac ccgcttcctc tacatgatcg
    17581 accggcgggt cgagcgcagg aactccgccg agctgaaggc gctgacgggc cgggccgagc
    17641 ggggcgcgga cgtgctgcgc ggcaccgccc gcgggttcga cacgctggtg cgcgacaccg
    17701 aggcgcgggt gcgcctcgcc gacgtggcgg gggatccgcc cgcgctggcc gccgcgcgcc
    17761 tggtggcgtc gcacgccggt ttcccggtga ccgcgccccc gcagggcggg gcgcacggcg
    17821 gcaggatcga cccgctgcag gccatcgcgc tcgcctccgg cgtgcgcacc cgcaggatca
    17881 ggctggacga ccgctggtgg cggcgggaca tcgggccgat ggtgggttac cgcgcctccg
    17941 acggggtgcc ggtggcgctg ctgcccatcg ggtcgcgcta cgtcgtggcc gcgccggggg
    18001 aggaacgcgt caccccggtc acggcggagg tcgccggcac gctgacccgg cacgccgacg
    18061 tgctgtacga gccgctgccg cccgccgtca ccggggtggg cgggctgctg cggttcgggc
    18121 tggccaagaa ccgcaaggac ctgtggaccc tgctcagcct gggcacgctg gtggccttca
    18181 tcggcctgct ggtgcccgcc atgaccggcc tcgtgctcgg cacgtacgtg gccagggccg
    18241 agcgcgagat gatcgtgcag ggcgcgctgc tggtgatcgc ggggtcgctc gtggcggcgg
    18301 ctctgtcggt ggtgcagaac ttcgccgcgc tgcgcatcga gggcaggtcg tcggcccgcc
    18361 tgcaggcggg cgcgtggatg cggctgctgt cgctgcccgc gaagttcttc accgactact
    18421 ccaccgccga gctgggcacc acggtcctcg gcgtgagcgc ggtgcaggag acgctgtcgg
    18481 gcgtcatgac gacggcggcg ctcgggctgt tcgccggcct ggccaacctc gtgctcgtct
    18541 tcttctacga cgtgcggctg gcgctgatcg cgtcggcgct cgtgctgatc ggcgtgctcg
    18601 tgtgcgcggt ggccggcttc ttcgaggtgc gcctgcagcg caggctctac acccacgagc
    18661 agcggctgtc gtcgcgggtc ttccagctcc tgacggcggt gccgaagctg cgggtggcgg
    18721 cggccgagga ccgggccttc ggggtctggt cgtcggagtt cctcaaggcg cgcagcgtcg
    18781 gcgtgtccgc ccgcagggtg cagaacttcg tcacgacctt caacgccggc ttcacgctgg
    18841 tcgcctcggt cgtcgtcttc gccgtggtgg ccgggccgat gctcggggag gtgaccgttc
    18901 ccgcgttctt ggcgttcttc gccgcgttca acctgctgct ggcctcggtg ctgcagttca
    18961 ccggcgcggc gatcaccgcg atgagcgtgg tgcccatgct ggagcggctg cggccgatcc
    19021 tggcggccga gcccgaggag cacgcgggca aggccgatcc cggcgagctg tcgggccgga
    19081 tcgagctgtc gcggacgtcg ttccggtacg gcgaggacgg gccgctcgtc ctggacgagg
    19141 tggacgtgtc gatcgagccg ggggagttcg tcgcgatcgt cggccccacc ggcagcggca
    19201 agtcgacgat cctgcggctg ctgctcggct tcgagtcgcc gagctccggc acggtcctgt
    19261 acgacggcca ggacctggac gagctggaca tcggcgcggt gcgccgccag tgcggggtgg
    19321 tcctgcagaa cagctcgctg ctcgcgggcg acatcaagac caacatcatc ggcagcaccg
    19381 atcacacgat cgacgacgcc tgggacgccg ccgccatggc gggcatcgcc gacgacatcg
    19441 cgaacatgcc gatgggcatg cacacggtgc tgtcggaggg caccaacacg ctgtcgggcg
    19501 ggcagcggca gcgcatcatg atcgcccgcg ccctcgtatc gcacccccgc atcgtgctgt
    19561 tcgacgaggc gacgagcgcg ctggacaacc ccacccagaa ggtcgtcacg gagagcaccc
    19621 gccagctcaa cgccacccgg atcgtgatcg cccaccggct ctcgacgatc agggacgccg
    19681 acaggatcgt ggtgctcgac cgcgggcgca tcgtccagca gggcaggtac caggaactgc
    19741 tggaggacgc cgacgggttg ttcgccaggc tggcccgccg ccagatctga ccccggcgag
    19801 gcgccgccgg cgggcctccg ccggcggcgt ccgcgtgctc agtagcgggg cttgcggctc
    19861 atcgcgatgg cgacgacgag gaacaccacg ccgagcgcgc cgtacacgaa ggcgtgggtg
    19921 gtggcgggcg gcttcacgct ggcgttggcg acggccagcc cgaggcccac gagggcgctg
    19981 atgtagcaga agatcgcgat gaagatcttc cagaaggggg tcatggcgta ctccgttcgg
    20041 actgcgcggg accgcccggt gcggtcccgg cgacgacgag gccgagcagc atgacccagg
    20101 cgtcggggtc ggcgcggaaa cgccgccacc ggtcggccgc cagggcgagc tcgggcaggg
    20161 acagggcccc ggaggcgacc agcggcgcca gccgctccgg ccccatgtgg ggggcgaacg
    20221 cctcggtggg gcggtcgtcg ttggtggtgg cgaacggccg cagcaccacc tcgtggaagc
    20281 ccgcgcggcg caggatccgg gtgagcttgc ggccgatcag ccggtcgcct ccggcctcgc
    20341 gctgcgcccc ggccatccgg ccgtggacgc cggccagctc cgggtacatc gggtcggcca
    20401 ggccccacag catgctgtcc acctcgacca cgaccagccg cccgcccggc cgcagcaccc
    20461 gcagggcctc ggccaccacc gccgcggggt cggccacgtg ctgcagtacg taccgcagca
    20521 ggaccgtgcc caccgcgccg tccgccagcg gcagccgtac ggcgtcgcag ccgatcagcg
    20581 ggacccgggc gtcggccgcg tgcgccagca gcgcggtgtc gatgtcggcg gccacgacgg
    20641 gcaggtccgg cagcgcggcc cgcagccgcc gagtgacggc gccggagccc gcgccgagct
    20701 ccagcagagg cgcggggacg ccgacgtcga gcagcacccg cagctcctcg tcgaaggaga
    20761 gcgccgcctg cgcctcgagg cgcgccagct cgccggacag gccgcccgcg gtcgtcgtgg
    20821 ccgggtcgta ggagcccgcg cccgtcgccg cgctcacggc cggctccccg cttgcctggg
    20881 cctcggcacc atcagcatgc cgtgcctggg acgtagcgtg acgagggcct cgggctccac
    20941 ggggaagccg gggacgagtt ccgggcgcac ggcgcgcagc agcacggcca gcacgagggt
    21001 ggcctccacc atcgcgaagt ggcggccgac gcacacccgc gggccgccgc cgaacgggag
    21061 gtactgatgc cccgcgtggg tgtgctcggc gaggaaccgg tcgggtgcgt acgtctcggg
    21121 gtcgtgccag tagcgcggat cccggtggag tacgtacggg ctgacgcata cgagcgtgcc
    21181 cggcggtatc gggtagccgc cgacgatgtc ggcctcgacg gagcgccggg agatgagcca
    21241 cacgggcgga tagagccgca tggcctcctt gatcgcccgc tggcaggccg tcagcctggg
    21301 catgtcggcg gcggtggcgg cccggtcatc gcccagcacc tcgtccacct ccgcccgcac
    21361 cgcccgagcg gcgtcgggat ggcggtcgag gagatagagc gtccaggtca gcgccttggc
    21421 cgtggtctcg tgcccggcca tgacgatcgt caggacctgg tcgcgcagtt cggtcgcggt
    21481 catcgcgtgc ccggaggcca gcatcgcgcc gagcaggtcg tcgccctcct gcccggtggc
    21541 ccgccgggcg gccacgatcg cccgggtgac gccgtcgagg aacgccttgg cccggcggaa
    21601 cccctctctg ccgcccttct ccgaggcggg gtcgaagtgg ccgatgaagc ggttgacctc
    21661 gtccaccgcc cgcccgaagc cgtcgccgac gcccgcgatg tcggtgccga gcatggcccg
    21721 cgcgatgacg gtgagcgtga gagaggtcag ttcgtggtcg acccggaccg ccgcgccctc
    21781 ctcgcccgcc cgccgccacc gctcggccag gccggccgcg gcgtcggtca tgatctcgtc
    21841 gaaccgctcg acctcggtcg ggcggaaggc cggggcgatc atcttgcgtt gcctggccca
    21901 gtcctcaccg ccgctggtca gcaggccgtt gccgagcaga gggcgcagca tgtcgtcgtc
    21961 gggcgtgcgg tccttggtgt agttggcgcc gttgtccttc agcacgtgcc tggccaggtc
    22021 gggcctgtgc agcatgtaga ccggcccggt ctccgtctcg tgcctggtca cgtcgccgta
    22081 ggcggccatc tccgtgacga agcgcagcgg ggcctcccgc atcgcgctca ggctctgggc
    22141 gtcccgcggc cccggcggca gggatacgta tcgattgtgc gtaccggcca tgcccacccc
    22201 caagttctcg gtaatacgta ttctctggaa attgcgcatg cgattcacgg tgaatacgta
    22261 ccgggtgata tttcctgatc ggagcatagt ctcggtcgtt gctggtctca atacttatgc
    22321 cccggcctga aaattaagtc tgtgcgggac ttcccggccg tgtaagactc cattttgaaa
    22381 gcggcgggac acatcgccgc gaaaaagccg ggaggctggt tatgtctttg gacccgaggc
    22441 agcgcgcgga attcgtgaac gcgtacaccc gcgttctcat cacggcatgg tcgagcgagg
    22501 aatactcggc gcggctggac tccgaccccc gctcggccct ggccgagtcc ggcctggagc
    22561 tgcccgcggg cgccgaggtc acgctcgtcc gcaacatccc ggaaggccac cacgacagca
    22621 acatcgaggt tcaggtcgcg ctgtgggaga ggggcctcga gacgggccgc ttcgaactgc
    22681 acatccccga gacgccgcag gtcgacatgg ccgagctgag cgagggcgac ctcgactcca
    22741 tcgcggccgg cgcgtccgcg gtcgaggcga tcgacatcaa ctgctgctgc tgcccctgct
    22801 gctgctgcac ctgacaatca cgatcccact cggaggacca ggccatgtcc acggtcgccg
    22861 accaggcgaa tcccgtccac gtgcgctccc tgcgcaagcg gtacggtccg gtgtgcgcgg
    22921 tcgaggaggt ggacctcgac gtgcggagcg gcgaggtgtt cgccctcctc gggccgaacg
    22981 gcgccggcaa gaccaccacg gtggagatcc tggtgggcgt acgccggcgg acctccggcg
    23041 aggtgcgcgt cctcggccac gacccggccg aggacgcgcc cgagtggcgc gccaggatcg
    23101 gcgtcgtccc ccagacgacg ggggcgtaca ccgacctgac cgtgcgcgag gtggtcgagc
    23161 acttcgcgtc cttctatccc gcgcccctgc cggtggccga ggtgatcgac atggtcggcc
    23221 tcggcaagca ggcgcgcaag caggcgcaga cgctctccgg cgggcaggcg cggcggctcg
    23281 acgtcgcggt gggcatcgtc ggagaccctg atctgatctt cctggacgag ccgacgacgg
    23341 ggctcgaccc cgtcgcccgc cgggaggcgt gggacctcgt gcgcttcttc gcccgccggg
    23401 gcaagaccac cgtgctcacc acccactacc tggacgaggt cgaggcgctg gcgcagcgcg
    23461 cggccgtcat cgtcaacggg cgggtcgtcg agtccggccc ggtgaacgag ctgggcggcc
    23521 ggcgcgcgac gccggccgcg ctgagcttcg ccaggccgga cgggctcggc gcgagcctgc
    23581 ccgcgctgcc gggcgacgcg gtggtggagg aggcggaggg cctggtcgtg gtgcgtacgc
    23641 accggccgac cgaggccatg gccgcgctgc tgccctgggc ggcggcctcc ggcgtccgcg
    23701 aactgccgga cctgcgcatc caccggccgt cgctggagga gatct
//
