GCF_012927245.1 - 31 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JABBGE010000001.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	NI-siderophore	172,068	201,837	High	desferrioxamin B/desferrioxamine E	other:other

NZ_JABBGE010000010.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	indole	20,374	43,580	Low	rebeccamycin	other:other
Region 2.2	hydrogen-cyanide	148,246	161,113	Low	aborycin	ribosomal:RiPP
Region 2.3	ectoine	263,667	269,498	Medium	ectoine	other:ectoine

NZ_JABBGE010000014.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	butyrolactone	3,731	14,738
Region 6.2	NI-siderophore	121,255	154,050	Low	kinamycin	PKS

NZ_JABBGE010000015.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	butyrolactone	2,372	13,304

NZ_JABBGE010000016.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	T3PKS	22,453	63,625	Medium	flaviolin/1,3,6,8-tetrahydroxynaphthalene	PKS

NZ_JABBGE010000018.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	RiPP-like	33,948	44,751

NZ_JABBGE010000002.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	RRE-containing	102,614	122,982	Low	bottromycin A2	ribosomal:RiPP:Bottromycin
Region 12.2	terpene-precursor	407,378	428,427
Region 12.3	melanin	698,905	709,303

NZ_JABBGE010000020.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	NRPS-like,T1PKS	1	19,124

NZ_JABBGE010000004.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	T2PKS,PKS-like,T1PKS	1	84,635	Low	simocyclinone D8	PKS:Type I+saccharide+other:aminocoumarin
Region 21.2	lanthipeptide-class-ii,NRPS,NRPS-like,T1PKS	88,988	167,757	Medium	birimositide	ribosomal:RiPP:Lanthipeptide
Region 21.3	RiPP-like	180,887	192,518
Region 21.4	butyrolactone	307,254	318,207
Region 21.5	cyanobactin	439,305	461,899	Low	nogalamycin	PKS
Region 21.6	terpene	582,678	609,147	High	hopene	terpene

NZ_JABBGE010000005.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	lassopeptide	24,840	47,371
Region 22.2	terpene	102,092	124,344	High	geosmin	terpene:Sesquiterpene
Region 22.3	lanthipeptide-class-v,terpene	385,646	429,148

NZ_JABBGE010000006.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 23.1	terpene-precursor	20,637	41,692
Region 23.2	terpene	376,693	397,955	High	2-methylisoborneol	terpene
Region 23.3	T1PKS	400,538	446,480	Low	sporolide A/sporolide B	NRPS:Type I+PKS:Enediyne type I
Region 23.4	lanthipeptide-class-ii	488,057	511,146
Region 23.5	NRP-metallophore,NRPS	512,112	569,144	Medium	peucechelin	NRPS:Type I

NZ_JABBGE010000007.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	lanthipeptide-class-iv	258,030	281,335	High	venezuelin	ribosomal:RiPP:Lanthipeptide
Region 24.2	terpene	395,537	416,673

NZ_JABBGE010000008.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 25.1	T1PKS	363,594	423,689	Low	scopranone A/scopranone B/scopranone C	PKS

NZ_JABBGE010000009.1 (Streptomyces sp. R302)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	PKS-like,butyrolactone	231,364	272,422

No secondary metabolite regions were found in these records:: NZ_JABBGE010000011.1 (Streptomyces sp. R302); NZ_JABBGE010000012.1 (Streptomyces sp. R302); NZ_JABBGE010000013.1 (Streptomyces sp. R302); NZ_JABBGE010000017.1 (Streptomyces sp. R302); NZ_JABBGE010000019.1 (Streptomyces sp. R302); NZ_JABBGE010000021.1 (Streptomyces sp. R302); NZ_JABBGE010000022.1 (Streptomyces sp. R302); NZ_JABBGE010000023.1 (Streptomyces sp. R302); NZ_JABBGE010000024.1 (Streptomyces sp. R302); NZ_JABBGE010000025.1 (Streptomyces sp. R302); NZ_JABBGE010000026.1 (Streptomyces sp. R302); NZ_JABBGE010000003.1 (Streptomyces sp. R302)

Compact view

NZ_JABBGE010000001.1 - Region 1 - NI-siderophore

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Location: 172,068 - 201,837 nt. (total: 29,770 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

HHL19_RS00850: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

HHL19_RS00870: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase

HHL19_RS00880: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

HHL19_RS00885: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: hydrolase

HHL19_RS00830: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase

HHL19_RS00855: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: synthase

HHL19_RS00875: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Translocases: transporter

HHL19_RS00790: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.83	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.82	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.75	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.75	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.63	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002690.2	0.60	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002284.3	0.58	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.83	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.82	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.75	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.75	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.63	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002690.2	0.60	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002284.3	0.58	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.65 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 30.11 out of 30.11

Confidence: strong

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.39 out of 26.85

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 34.36 out of 36.53

Confidence: strong

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.79 out of 23.43

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.94 out of 36.53

Confidence: medium

Additional weak hits (9):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.48 out of 27.78

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.30 out of 18.57

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.67 out of 30.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.30 out of 27.04

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.36 out of 26.06

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.40 out of 36.53

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.59 out of 27.04

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.49 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
CelR	Cellobiose uptake repressor
DmdR1	Iron(II)-dependent repressor
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JABBGE010000010.1 - Region 1 - indole

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Location: 20,374 - 43,580 nt. (total: 23,207 nt) Show pHMM detection rules used

indole: (indsynth or dmat or indole_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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other genes

resistance

TTA codons

binding site

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Gene overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HHL19_RS28620: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HHL19_RS28625: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HHL19_RS28640: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Hydrolases: hydrolase

HHL19_RS28605: isochorismatase

smcogs: SMCOG1027: isochorismatase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001224.5	0.62	other (other)	reductasporine	uncultured bacterium
BGC0001223.5	0.60	other (other)	hydroxysporine	uncultured bacterium
BGC0001336.5	0.59	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000817.4	0.53	other (other)	methylarcyriarubin	uncultured bacterium
BGC0000829.5	0.47	other (other)	violacein	Chromobacterium violaceum
BGC0000821.5	0.47	other (other)	rebeccamycin	Lechevalieria aerocolonigenes
BGC0000813.3	0.45	other (other)	K-252a	Nonomuraea longicatena
BGC0000830.5	0.44	other (aminocoumarin)	violacein	uncultured bacterium
BGC0000831.3	0.44	other (other)	violacein	Duganella sp. B2
BGC0002482.2	0.43	other (other)	tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M	Symphyonema bifilamentata 97.28

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001224.5	0.62	other (other)	reductasporine	uncultured bacterium
BGC0001223.5	0.60	other (other)	hydroxysporine	uncultured bacterium
BGC0001336.5	0.59	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000817.4	0.53	other (other)	methylarcyriarubin	uncultured bacterium
BGC0000829.5	0.47	other (other)	violacein	Chromobacterium violaceum
BGC0000821.5	0.47	other (other)	rebeccamycin	Lechevalieria aerocolonigenes
BGC0000813.3	0.45	other (other)	K-252a	Nonomuraea longicatena
BGC0000830.5	0.44	other (aminocoumarin)	violacein	uncultured bacterium
BGC0000831.3	0.44	other (other)	violacein	Duganella sp. B2
BGC0002482.2	0.43	other (other)	tjipanazole D, tjipanazole I, tjipanazole L, tjipanazole K, tjipanazole M	Symphyonema bifilamentata 97.28

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.27 out of 25.31

Confidence: medium

Additional weak hits (7):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.70 out of 20.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 13.86 out of 21.55

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.71 out of 25.88

Confidence: weak

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 17.94 out of 23.05

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.04 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.98 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor

NZ_JABBGE010000010.1 - Region 2 - hydrogen-cyanide

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Location: 148,246 - 161,113 nt. (total: 12,868 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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other genes

resistance

TTA codons

binding site

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Gene overview

Tailoring

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Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

HHL19_RS29160: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

HHL19_RS29170: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: deaminase

HHL19_RS29190: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002285.2	0.30	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000595.3	0.25	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000971.5	0.24	NRPS, PKS	cinnabaramide A	Streptomyces cinnabarigriseus
BGC0001387.5	0.24	other (other)	nucleocidin	Streptomyces calvus
BGC0001041.4	0.23	NRPS, PKS	salinosporamide A	Salinispora tropica CNB-440
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0000290.5	0.22	NRPS	A-47934	Streptomyces toyocaensis
BGC0000135.5	0.21	PKS	reveromycin A	Streptomyces sp. SN-593
BGC0000378.5	0.20	NRPS	Kutzneride 1, Kutzneride 2, Kutzneride 3, Kutzneride 4, Kutzneride 5, Kutzneride 6, Kutzneride 7, Kutzneride 8	Kutzneria sp. 744

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002285.2	0.30	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000595.3	0.25	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000971.5	0.24	NRPS, PKS	cinnabaramide A	Streptomyces cinnabarigriseus
BGC0001387.5	0.24	other (other)	nucleocidin	Streptomyces calvus
BGC0001041.4	0.23	NRPS, PKS	salinosporamide A	Salinispora tropica CNB-440
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0000290.5	0.22	NRPS	A-47934	Streptomyces toyocaensis
BGC0000135.5	0.21	PKS	reveromycin A	Streptomyces sp. SN-593
BGC0000378.5	0.20	NRPS	Kutzneride 1, Kutzneride 2, Kutzneride 3, Kutzneride 4, Kutzneride 5, Kutzneride 6, Kutzneride 7, Kutzneride 8	Kutzneria sp. 744

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (6):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.29 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.09 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.76 out of 21.84

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 16.96 out of 22.40

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JABBGE010000010.1 - Region 3 - ectoine

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Location: 263,667 - 269,498 nt. (total: 5,832 nt) Show pHMM detection rules used

Region on contig edge.

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.76	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.76	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.69	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.65	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.65	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.65	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.65	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.59	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.76	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.76	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.69	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.65	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.65	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.65	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.65	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.59	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

NZ_JABBGE010000014.1 - Region 1 - butyrolactone

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Location: 3,731 - 14,738 nt. (total: 11,008 nt) Show pHMM detection rules used

Region on contig edge.

butyrolactone: AfsA

Legend:

core biosynthetic genes

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transport-related genes

regulatory genes

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Gene details

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Gene overview

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Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: kinase

HHL19_RS33060: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.78	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.71	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.65	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.39	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000528.5	0.36	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001302.5	0.34	other (other)	lomofungin	Streptomyces lomondensis
BGC0000506.4	0.33	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.4	0.33	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000537.3	0.32	ribosomal	nisin U	Streptococcus uberis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.78	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.71	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.65	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.39	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000528.5	0.36	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001302.5	0.34	other (other)	lomofungin	Streptomyces lomondensis
BGC0000506.4	0.33	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.4	0.33	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000537.3	0.32	ribosomal	nisin U	Streptococcus uberis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.02 out of 25.31

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.59 out of 25.88

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (6):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.20 out of 27.78

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.16 out of 30.22

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.17 out of 35.63

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.33 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.68 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
PsrA	Oleic acid responsive regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_JABBGE010000014.1 - Region 2 - NI-siderophore

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Location: 121,255 - 154,050 nt. (total: 32,796 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HHL19_RS33570: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: aminotransferase

HHL19_RS33615: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Isomerases: mutase

HHL19_RS33555: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001713.5	0.54	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002469.2	0.53	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002683.2	0.53	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3	0.53	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002470.2	0.52	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0000295.5	0.52	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002633.2	0.52	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002305.2	0.51	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001713.5	0.54	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002469.2	0.53	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002683.2	0.53	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3	0.53	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002470.2	0.52	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0000295.5	0.52	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002633.2	0.52	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002305.2	0.51	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.93 out of 27.18

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78

Confidence: medium

Additional weak hits (9):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 26.33

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.88 out of 20.97

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.09 out of 36.54

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.43 out of 32.93

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.57 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.78 out of 24.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.88 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
LexA variant 2	Repressor of DNA damage response
NrdR	Represses ribonucleotide reductase encoding genes
VqsM	Regulator of quorum-sensing signalling systems

NZ_JABBGE010000015.1 - Region 1 - butyrolactone

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Location: 2,372 - 13,304 nt. (total: 10,933 nt) Show pHMM detection rules used

Region on contig edge.

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

HHL19_RS33975: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.77	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.77	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.55	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.38	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000914.5	0.29	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0001083.5	0.26	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000883.5	0.26	other (other)	arginomycin	Streptomyces arginensis
BGC0002673.2	0.25	PKS, other (other)	iminimycin A, iminimycin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002439.3	0.25	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0001771.4	0.24	NRPS	scleric acid	Streptomyces sclerotialus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.77	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.77	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.55	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.38	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000914.5	0.29	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0001083.5	0.26	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0000883.5	0.26	other (other)	arginomycin	Streptomyces arginensis
BGC0002673.2	0.25	PKS, other (other)	iminimycin A, iminimycin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002439.3	0.25	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0001771.4	0.24	NRPS	scleric acid	Streptomyces sclerotialus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.99 out of 30.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.72 out of 24.78

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.55 out of 18.57

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.02 out of 24.78

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.37 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.43 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.55 out of 18.57

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JABBGE010000016.1 - Region 1 - T3PKS

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Location: 22,453 - 63,625 nt. (total: 41,173 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene overview

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HHL19_RS34835: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: back translocase protease

HHL19_RS34770: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

HHL19_RS38635: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthase

HHL19_RS34830: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.71	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.66	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.59	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000285.5	0.54	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0001948.3	0.49	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000280.5	0.45	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000281.3	0.43	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0001336.5	0.42	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.71	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.66	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.59	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000285.5	0.54	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0001948.3	0.49	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000280.5	0.45	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000281.3	0.43	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0001336.5	0.42	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.77 out of 27.04

Confidence: medium

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.79 out of 23.43

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.71 out of 20.47

Confidence: medium

Additional weak hits (9):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.80 out of 29.38

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.20 out of 21.55

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.29 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.30 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.08 out of 18.57

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.77 out of 31.73

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 16.96 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.58 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.24 out of 25.88

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
DasR	N-acetylglucosamine dependent repressor
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_JABBGE010000018.1 - Region 1 - RiPP-like

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Location: 33,948 - 44,751 nt. (total: 10,804 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer

HHL19_RS36065: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

HHL19_RS36085: flavodoxin

smcogs: SMCOG1134: flavodoxin

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000249.5	0.37	PKS	nogalamycin	Streptomyces nogalater
BGC0001485.4	0.36	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0001137.5	0.31	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000243.4	0.30	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001188.3	0.29	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0002046.3	0.28	NRPS, PKS	lobatamide A	Gynuella sunshinyii YC6258
BGC0001882.3	0.27	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0001203.4	0.27	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456
BGC0000935.5	0.25	PKS, other (aminocoumarin)	esmeraldin	Streptomyces antibioticus
BGC0002010.4	0.24	NRPS, PKS	streptophenazine B, streptophenazine C, streptophenazine F, streptophenazine G, streptophenazine H	Streptomyces sp. CNB091

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000249.5	0.37	PKS	nogalamycin	Streptomyces nogalater
BGC0001485.4	0.36	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0001137.5	0.31	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000243.4	0.30	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001188.3	0.29	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0002046.3	0.28	NRPS, PKS	lobatamide A	Gynuella sunshinyii YC6258
BGC0001882.3	0.27	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0001203.4	0.27	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456
BGC0000935.5	0.25	PKS, other (aminocoumarin)	esmeraldin	Streptomyces antibioticus
BGC0002010.4	0.24	NRPS, PKS	streptophenazine B, streptophenazine C, streptophenazine F, streptophenazine G, streptophenazine H	Streptomyces sp. CNB091

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

NZ_JABBGE010000002.1 - Region 1 - RRE-containing

Download region GenBank file

Download region SVG

Location: 102,614 - 122,982 nt. (total: 20,369 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

HHL19_RS06480: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

HHL19_RS06515: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

HHL19_RS06530: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: Methylation

HHL19_RS06500: Methylation

MITE: MITE0000049Methylation (identity: 67.20%)

Hydrolases: Hydrolysis dehalogenase

HHL19_RS06475: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

HHL19_RS06510: Hydrolysis

MITE: MITE0000048Hydrolysis (identity: 72.80%)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000470.6	0.47	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0000469.6	0.45	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0000468.5	0.43	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0001157.6	0.43	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0002007.2	0.38	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002716.2	0.34	NRPS	gamexpeptide A, gamexpeptide B, gamexpeptide E, luminmide B, luminmide D, luminmide E, luminmide F, luminmide G	Photorhabdus laumondii subsp. laumondii
BGC0002039.3	0.34	other (other)	coformycin, formycin A	Nocardia interforma ATCC 21072
BGC0002282.2	0.34	other (other)	formycin A	Streptomyces kaniharaensis
BGC0002040.3	0.33	other (other)	coformycin, formycin A	Streptomyces kaniharaensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000470.6	0.47	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0000469.6	0.45	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0000468.5	0.43	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0001157.6	0.43	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0002007.2	0.38	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002716.2	0.34	NRPS	gamexpeptide A, gamexpeptide B, gamexpeptide E, luminmide B, luminmide D, luminmide E, luminmide F, luminmide G	Photorhabdus laumondii subsp. laumondii
BGC0002039.3	0.34	other (other)	coformycin, formycin A	Nocardia interforma ATCC 21072
BGC0002282.2	0.34	other (other)	formycin A	Streptomyces kaniharaensis
BGC0002040.3	0.33	other (other)	coformycin, formycin A	Streptomyces kaniharaensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (6):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.89 out of 32.74

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.28 out of 27.78

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.27 out of 18.57

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.32 out of 30.98

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.96 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.23 out of 29.65

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Bottromycin_Methyltransferase_RRE; Location: 13 - 84; Score: 92.6

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_JABBGE010000002.1 - Region 2 - terpene-precursor

Download region GenBank file

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Location: 407,378 - 428,427 nt. (total: 21,050 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

HHL19_RS07715: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002400.2	0.43	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000677.5	0.38	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000665.5	0.34	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001911.3	0.34	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.33	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002400.2	0.43	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000677.5	0.38	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000665.5	0.34	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001911.3	0.34	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.33	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

HHL19_RS07715: PT_FPPS_like

Domain 1 (61 - 344): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

Additional weak hits (6):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.76 out of 20.01

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.19 out of 31.73

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.43 out of 32.93

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.30 out of 36.54

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.04 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ToxT	Regulator of MSHA biosynthesis

NZ_JABBGE010000002.1 - Region 3 - melanin

Download region GenBank file

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Location: 698,905 - 709,303 nt. (total: 10,399 nt) Show pHMM detection rules used

melanin: melC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000910.3	0.81	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000911.3	0.80	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000909.3	0.64	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.60	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000908.3	0.47	other (other)	melanin	Streptomyces avermitilis
BGC0000885.3	0.34	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000662.5	0.34	terpene	grixazone A	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000889.5	0.34	other (other)	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001592.5	0.33	other (other)	ferroverdin, bagremycin	Streptomyces lunaelactis
BGC0000700.5	0.26	saccharide	istamycin	Streptomyces tenjimariensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000910.3	0.81	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000911.3	0.80	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000909.3	0.64	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.60	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000908.3	0.47	other (other)	melanin	Streptomyces avermitilis
BGC0000885.3	0.34	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000662.5	0.34	terpene	grixazone A	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000889.5	0.34	other (other)	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0001592.5	0.33	other (other)	ferroverdin, bagremycin	Streptomyces lunaelactis
BGC0000700.5	0.26	saccharide	istamycin	Streptomyces tenjimariensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.45 out of 27.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.27 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JABBGE010000020.1 - Region 1 - NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 19,124 nt. (total: 19,124 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HHL19_RS38660: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acylase

HHL19_RS36500: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: ligase

HHL19_RS36530: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0000107.3	0.59	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.58	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002192.3	0.57	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.55	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002171.2	0.37	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.37	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002238.3	0.29	PKS	2,4'-dihydroxy-3'-methoxypropiophenone	Aspergillus oryzae RIB40
BGC0001998.2	0.29	PKS	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001400.3	0.28	PKS	citreoviridin	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002192.3	0.62	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002171.2	0.50	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.50	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002238.3	0.44	PKS	2,4'-dihydroxy-3'-methoxypropiophenone	Aspergillus oryzae RIB40
BGC0001998.2	0.44	PKS	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001400.3	0.43	PKS	citreoviridin	Aspergillus terreus NIH2624

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.49 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.37 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.22 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.15 out of 28.19

Confidence: medium

Additional weak hits (8):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.57 out of 29.38

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.42 out of 20.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.45 out of 26.06

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.62 out of 20.01

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.10 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.04 out of 24.78

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 19124:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HHL19_RS36500: mmal

PKS_AT (780..1076): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 75.0%; Malonyl-CoA: 70.8%; Methoxymalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 161.3
Ethylmalonyl-CoA: 142.9
Methoxymalonyl-CoA: 132.4
2-Methylbutyryl-CoA: 124.0
CHC-CoA: 112.2
Propionyl-CoA: 110.3
trans-1,2-CPDA: 96.3
Malonyl-CoA: 90.0
Isobutyryl-CoA: 63.0
Benzoyl-CoA: 28.3
fatty_acid: 21.2
inactive: 18.4
Acetyl-CoA: 13.7
3-Methylbutyryl-CoA: 12.3

HHL19_RS36530: X

AMP-binding (35..415): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GQLLHLFGMQYHHALSGGADGAYGLTENTCHFTR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_JABBGE010000004.1 - Region 1 - PKS-like,T1PKS,T2PKS

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Location: 1 - 84,635 nt. (total: 84,635 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

HHL19_RS13245: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HHL19_RS13255: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HHL19_RS13260: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HHL19_RS13310: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

HHL19_RS13325: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HHL19_RS13335: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

HHL19_RS13380: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HHL19_RS13405: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

HHL19_RS13420: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HHL19_RS13425: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

HHL19_RS13435: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

HHL19_RS13450: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: PPTase acylase aminotransferase halogenase methyltransferase transferase

HHL19_RS13280: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

HHL19_RS13290: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

HHL19_RS13330: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

HHL19_RS13340: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

HHL19_RS13370: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

HHL19_RS13395: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

HHL19_RS13400: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

HHL19_RS13365: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: cyclase

HHL19_RS13225: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

HHL19_RS13250: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

HHL19_RS13230: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HHL19_RS13235: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

HHL19_RS13360: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

HHL19_RS13390: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	0.87	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.84	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.68	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000016.4	0.67	other (other)	amphotericin B	Streptomyces nodosus
BGC0001160.5	0.56	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001723.5	0.56	PKS	oviedomycin	Streptomyces antibioticus
BGC0000218.5	0.53	PKS	doxorubicin	Streptomyces peucetius
BGC0000235.5	0.53	PKS	kiamycin	Streptomyces sp. W007
BGC0001895.4	0.52	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0001254.3	0.52	PKS	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.82	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.73	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.73	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.73	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002047.2	0.69	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000041.3	0.66	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.72 out of 20.47

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

Additional weak hits (19):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.09 out of 28.14

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.91 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.61 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.55 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.61 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.67 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.55 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.99 out of 27.78

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.79 out of 30.97

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.87 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 30.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.95 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.32 out of 30.98

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.88 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.47 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.78 out of 32.93

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.23 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Type II PKS

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 84635:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - mal) + (Me-ccmal)
Non-colinear ordering:: HHL19_RS13390 + HHL19_RS13395 + HHL19_RS13400

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 38106:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 6615 - 47596:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 14776 - 84635:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - mal) + (Me-ccmal)
Non-colinear ordering:: HHL19_RS13390 + HHL19_RS13395 + HHL19_RS13400

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HHL19_RS13390: mal - mal - mal

PKS_AT (520..811): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.7
inactive: 87.8
Methoxymalonyl-CoA: 73.2
Methylmalonyl-CoA: 67.1
Propionyl-CoA: 29.0
Isobutyryl-CoA: 27.1
Benzoyl-CoA: 22.4
Ethylmalonyl-CoA: 21.2
Acetyl-CoA: 18.5
CHC-CoA: 13.2
2-Methylbutyryl-CoA: 12.1
fatty_acid: 10.0
trans-1,2-CPDA: 9.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (1530..1827): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.4
inactive: 94.6
Methoxymalonyl-CoA: 70.4
Methylmalonyl-CoA: 68.4
Isobutyryl-CoA: 48.4
Propionyl-CoA: 37.1
Ethylmalonyl-CoA: 26.9
2-Methylbutyryl-CoA: 21.6
Acetyl-CoA: 20.4
fatty_acid: 15.5
trans-1,2-CPDA: 15.0
3-Methylbutyryl-CoA: 13.0
CHC-CoA: 10.5
Benzoyl-CoA: 4.8

PKS_AT (3272..3572): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.4
inactive: 101.9
Methoxymalonyl-CoA: 54.0
Methylmalonyl-CoA: 42.6
Propionyl-CoA: 33.3
Isobutyryl-CoA: 21.1
Acetyl-CoA: 11.1
fatty_acid: 11.0
Benzoyl-CoA: 9.5
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

HHL19_RS13395: mal - mal

PKS_AT (578..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.5
inactive: 81.4
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 65.5
Propionyl-CoA: 29.0
Isobutyryl-CoA: 23.3
Ethylmalonyl-CoA: 22.4
Benzoyl-CoA: 22.4
Acetyl-CoA: 18.7
2-Methylbutyryl-CoA: 13.6
CHC-CoA: 12.2
trans-1,2-CPDA: 11.6
fatty_acid: 9.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (2307..2594): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.0
inactive: 84.6
Methoxymalonyl-CoA: 74.1
Methylmalonyl-CoA: 66.4
Propionyl-CoA: 29.1
Isobutyryl-CoA: 23.6
Ethylmalonyl-CoA: 23.0
Benzoyl-CoA: 22.4
Acetyl-CoA: 18.5
CHC-CoA: 13.4
2-Methylbutyryl-CoA: 11.6
trans-1,2-CPDA: 9.3
fatty_acid: 9.3
3-Methylbutyryl-CoA: 0.0

HHL19_RS13400: mmal

PKS_AT (597..895): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.5
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 146.9
Propionyl-CoA: 117.2
trans-1,2-CPDA: 115.3
Malonyl-CoA: 103.7
CHC-CoA: 97.4
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 71.1
Acetyl-CoA: 48.8
3-Methylbutyryl-CoA: 43.9
fatty_acid: 40.0
inactive: 35.9

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 38106
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 716.5; E-value: 1.8e-218)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 433 Da
acetyl-CoA_9: 475 Da

HHL19_RS13225: CYC C4-C17/C2-C19 (Score: 202.8; E-value: 1.1e-62)
HHL19_RS13230: KS (Score: 786.7; E-value: 1.1e-239)
HHL19_RS13235: CLF 8|9 (Score: 716.5; E-value: 1.8e-218)
HHL19_RS13240: ACP (Score: 127.2; E-value: 4.4e-40)
HHL19_RS13245: KR C9 (Score: 476.3; E-value: 5.1e-146)
HHL19_RS13250: CYC C7-C12 (Score: 485.9; E-value: 9.4e-149)
HHL19_RS13255: OXY (Score: 562.9; E-value: 1.4e-171)
HHL19_RS13260: OXY (Score: 575.0; E-value: 3e-175)
HHL19_RS13325: OXY (Score: 516.3; E-value: 1.9e-157)
HHL19_RS13330: HAL (Score: 432.5; E-value: 4.1e-132)
HHL19_RS13340: MET (Score: 291.5; E-value: 1.9e-89)
HHL19_RS13380: KR (Score: 154.3; E-value: 1.1e-47)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_JABBGE010000004.1 - Region 2 - NRPS,NRPS-like,T1PKS,lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 88,988 - 167,757 nt. (total: 78,770 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

HHL19_RS13585: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: acylase carbamoyltransferase

HHL19_RS13520: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

HHL19_RS13670: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: cyclase lyase

HHL19_RS13550: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

HHL19_RS13580: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

HHL19_RS13635: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

HHL19_RS13535: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HHL19_RS13640: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

HHL19_RS13645: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HHL19_RS13660: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

HHL19_RS13665: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HHL19_RS13715: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Translocases: permease transporter

HHL19_RS13680: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

HHL19_RS13720: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.92	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.91	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002192.3	0.90	PKS	FR901512	fungal sp. No.14919
BGC0001276.3	0.90	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.89	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.89	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.89	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.89	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001166.5	0.88	NRPS	HC-toxin	Alternaria jesenskae
BGC0001164.3	0.87	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002110.3	0.67	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for HHL19_RS13550

HHL19_RS13545

Leader:

MTNYDGDISLIEEIAEQDFDGVAYGA

Core:

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDFLGNQGGWCysDhbLDhbKECysQPNCysN

antiSMASH-DB 4.0 matches for HHL19_RS13545

100.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

93.3%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD+LGNQGGWCTLTKECQPNCN

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

30

90.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQPNCN

1

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

30

with 102 more sequence matches

Only the first 10 are displayed here.

86.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQ NCN

1

CTTNTFSLSDALGNHGGWCTLTKECQANCN

30

86.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLT ECQPNCN

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

86.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD +GN GGWCTLTKECQPNCN

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

30

86.7%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQPNC+

1

CTTNTFSLSDALGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQPNC+

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNCS

30

86.7%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide

Lanthipeptides: K378_RS05175_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD L NQGGWCTLT ECQPNCN

1

CTTNTFSLSDALTNQGGWCTLTVECQPNCN

30

83.3%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD L N GGWCTLT ECQPNCN

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

80.0%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNC

29

C+TNTF+LS+ LGNQGGWCTLT ECQPNC

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNC

29

80.0%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide

Lanthipeptides: LHJ74_RS33590_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

CSTNTFSLSD GN G WCTLTKECQ CN

1

CSTNTFSLSDAAGNDGWWCTLTKECQRTCN

30

80.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTF+LSD+LGN+GGWCTLTKECQ +CN

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for HHL19_RS13545

86.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLS+ LGN GGWCTLTKECQPNCN

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

46.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDFLGNQGGWCTLTKECQPNCN

30

+++S LGN+G +CTLT EC P+CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

28.2%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTKECQPNCN

30

CTL+KECQPNCN

28

CTLSKECQPNCN

39

HHL19_RS13570

Leader:

MEKMQADVLGGYDEFELVEMGEADVYGG

Core:

TTWSCAVVTAVATLVSASACPTTKCTSQC

Core with dehydrations:

DhbDhbWDhaCysAVVDhbAVADhbLVDhaADhaACysPDhbDhbKCysDhbDhaQCys

antiSMASH-DB 4.0 matches for HHL19_RS13570

100.0%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTWSCAVVTAVATLVSASACPTTKCTSQC

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

69.0%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

1

TTWSCAVVTAVATLVSASA--CPTTKCTSQC

29

TTW+C AV+T+V AS CPTTKCTSQC

1

TTWACV---AVSTIVDASISLCPTTKCTSQC

28

60.9%

NZ_AKXV01000031.1and 3 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTWSCA+VTAVATLVSASACPTTKCTSQC

18

TTWSCAIVTAVATLVSASACPTTKCTSQC

46

with 97 more sequence matches

Only the first 10 are displayed here.

58.6%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTW+C V+ V S S CPTTKCTS+C

1

TTWACVAVSTVVE-ASISLCPTTKCTSKC

28

48.7%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

3

WSCAVVTAVATLVSASACPTTKCTSQC

29

W+C +TA T VSAS CPTTKCTSQC

16

WTC--ITAGVT-VSASLCPTTKCTSQC

39

47.4%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

3

WSCAVVTAVATLVSASACPTTKCTSQC

29

W+C +TA T VSAS CPTTKCTS+C

15

WTC--ITAGVT-VSASLCPTTKCTSRC

38

45.5%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTW CA+ T + SA+ CPTT C+S+C

8

TTWGCAIFT----IASAAQCPTTACSSKC

32

42.9%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

T W CA VT L +A+ CPTTKCTSQC

18

TAWVCATVT----LATAAICPTTKCTSQC

42

41.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

5

CAVVTAVATLVSASACPTTKCTSQC

29

CAV AV VS + CPTT CTS C

11

CAVTLAVCVPVSLAFCPTTACTSDC

35

41.4%

NZ_BIFH01000022.1and 1 other:

NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide

Lanthipeptides: EMA17_RS52585_lanthipeptide

6

AVVTAVATLVSASACPTTKCTSQC

29

A+ A TL++A+ CPTT C+S+C

5

ALCVATITLITATMCPTTACSSKC

28

41.4%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TT CAV ++A CPT C+S+C

2

TTVPCAVAASIAL------CPTLACSSKC

24

41.4%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

7

VVTAVATLVSASACPTTKCTSQC

29

V+TAV +S + CPTT CT C

6

VITAVTGYISTNTCPTTSCTRAC

28

41.4%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

++W C V SA+ CP+T CTS+C

7

SSWICGVA-------SAAFCPSTACTSKC

28

MIBiG 4.0 matches for HHL19_RS13570

40.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

6

AVVTAVATLVSASACPTTKCTSQC

29

A+ VA VSA+ CPTTKCTS+C

14

AIQAGVAVGVSAAFCPTTKCTSRC

37

31.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

20

CPTTKCTSQC

29

CPTTKCTS+C

17

CPTTKCTSKC

26

17.2%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

5

CAVVTAVATLVSASA

19

C + +V+ +SA+A

5

CTIYASVSASISATA

19

Lanthipeptide(s) for HHL19_RS13580

HHL19_RS13545

Leader:

MTNYDGDISLIEEIAEQDFDGVAYGA

Core:

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDFLGNQGGWCysDhbLDhbKECysQPNCysN

antiSMASH-DB 4.0 matches for HHL19_RS13545

100.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

93.3%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD+LGNQGGWCTLTKECQPNCN

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

30

90.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQPNCN

1

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

30

with 102 more sequence matches

Only the first 10 are displayed here.

86.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQ NCN

1

CTTNTFSLSDALGNHGGWCTLTKECQANCN

30

86.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLT ECQPNCN

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

86.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD +GN GGWCTLTKECQPNCN

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

30

86.7%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQPNC+

1

CTTNTFSLSDALGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD LGN GGWCTLTKECQPNC+

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNCS

30

86.7%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide

Lanthipeptides: K378_RS05175_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD L NQGGWCTLT ECQPNCN

1

CTTNTFSLSDALTNQGGWCTLTVECQPNCN

30

83.3%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLSD L N GGWCTLT ECQPNCN

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

80.0%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNC

29

C+TNTF+LS+ LGNQGGWCTLT ECQPNC

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNC

29

80.0%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide

Lanthipeptides: LHJ74_RS33590_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

CSTNTFSLSD GN G WCTLTKECQ CN

1

CSTNTFSLSDAAGNDGWWCTLTKECQRTCN

30

80.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTF+LSD+LGN+GGWCTLTKECQ +CN

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for HHL19_RS13545

86.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

C+TNTFSLS+ LGN GGWCTLTKECQPNCN

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

46.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDFLGNQGGWCTLTKECQPNCN

30

+++S LGN+G +CTLT EC P+CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

28.2%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTKECQPNCN

30

CTL+KECQPNCN

28

CTLSKECQPNCN

39

HHL19_RS13570

Leader:

MEKMQADVLGGYDEFELVEMGEADVYGG

Core:

TTWSCAVVTAVATLVSASACPTTKCTSQC

Core with dehydrations:

DhbDhbWDhaCysAVVDhbAVADhbLVDhaADhaACysPDhbDhbKCysDhbDhaQCys

antiSMASH-DB 4.0 matches for HHL19_RS13570

100.0%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTWSCAVVTAVATLVSASACPTTKCTSQC

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

69.0%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

1

TTWSCAVVTAVATLVSASA--CPTTKCTSQC

29

TTW+C AV+T+V AS CPTTKCTSQC

1

TTWACV---AVSTIVDASISLCPTTKCTSQC

28

60.9%

NZ_AKXV01000031.1and 3 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTWSCA+VTAVATLVSASACPTTKCTSQC

18

TTWSCAIVTAVATLVSASACPTTKCTSQC

46

with 97 more sequence matches

Only the first 10 are displayed here.

58.6%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTW+C V+ V S S CPTTKCTS+C

1

TTWACVAVSTVVE-ASISLCPTTKCTSKC

28

48.7%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

3

WSCAVVTAVATLVSASACPTTKCTSQC

29

W+C +TA T VSAS CPTTKCTSQC

16

WTC--ITAGVT-VSASLCPTTKCTSQC

39

47.4%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

3

WSCAVVTAVATLVSASACPTTKCTSQC

29

W+C +TA T VSAS CPTTKCTS+C

15

WTC--ITAGVT-VSASLCPTTKCTSRC

38

45.5%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TTW CA+ T + SA+ CPTT C+S+C

8

TTWGCAIFT----IASAAQCPTTACSSKC

32

42.9%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

T W CA VT L +A+ CPTTKCTSQC

18

TAWVCATVT----LATAAICPTTKCTSQC

42

41.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

5

CAVVTAVATLVSASACPTTKCTSQC

29

CAV AV VS + CPTT CTS C

11

CAVTLAVCVPVSLAFCPTTACTSDC

35

41.4%

NZ_BIFH01000022.1and 1 other:

NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide

Lanthipeptides: EMA17_RS52585_lanthipeptide

6

AVVTAVATLVSASACPTTKCTSQC

29

A+ A TL++A+ CPTT C+S+C

5

ALCVATITLITATMCPTTACSSKC

28

41.4%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

TT CAV ++A CPT C+S+C

2

TTVPCAVAASIAL------CPTLACSSKC

24

41.4%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

7

VVTAVATLVSASACPTTKCTSQC

29

V+TAV +S + CPTT CT C

6

VITAVTGYISTNTCPTTSCTRAC

28

41.4%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

1

TTWSCAVVTAVATLVSASACPTTKCTSQC

29

++W C V SA+ CP+T CTS+C

7

SSWICGVA-------SAAFCPSTACTSKC

28

MIBiG 4.0 matches for HHL19_RS13570

40.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

6

AVVTAVATLVSASACPTTKCTSQC

29

A+ VA VSA+ CPTTKCTS+C

14

AIQAGVAVGVSAAFCPTTKCTSRC

37

31.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

20

CPTTKCTSQC

29

CPTTKCTS+C

17

CPTTKCTSKC

26

17.2%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

5

CAVVTAVATLVSASA

19

C + +V+ +SA+A

5

CTIYASVSASISATA

19

HHL19_RS13610

Leader:

MMRTVIGRAALGIAAA

Core:

VLTVSATAGAGGGVVLAEDRCLGAPAVCGPVNGWQETPDD

Core with dehydrations:

VLDhbVDhaADhbAGAGGGVVLAEDRCysLGAPAVCysGPVNGWQEDhbPDD

antiSMASH-DB 4.0 matches for HHL19_RS13610

100.0%

NZ_JABBGE010000004.1:

Lanthipeptides: HHL19_RS13610_lanthipeptide

1

VLTVSATAGAGGGVVLAEDRCLGAPAVCGPVNGWQETPDD

40

VLTVSATAGAGGGVVLAEDRCLGAPAVCGPVNGWQETPDD

1

VLTVSATAGAGGGVVLAEDRCLGAPAVCGPVNGWQETPDD

40

30.0%

NZ_CP035119.1:

Lanthipeptides: allorf_0901569_0901715_lanthipeptide

8

AGAGGGV--VLAEDRCLGAPAVCGPVNGWQET

37

AG+ GV VL C +CG V W+E+

1

AGSMRGVTRVLTAACCAACERLCGDVWDWRES

32

22.5%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

9

GAGGGVVLAEDRCLGAPAVCG

29

G G G V++ C GA V G

1

GQGWGTVMSSLSCYGASYVLG

21

with 5 more sequence matches

22.5%

NZ_FNYB01000007.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS28100_lanthipeptide

Lanthipeptides: BMZ34_RS15340_lanthipeptide

9

GAGGGVVLAEDRCLGAPAVCGPVNG

33

G G L +D P +C P+NG

2

GPGYIETLTKDCPRVTPQICVPING

26

17.8%

NZ_JAMYJM010000002.1:

Lanthipeptides: NKE69_RS04880_lanthipeptide

4

VSATAGAGGGVVLAEDRCLG

23

+SA GG+V + CLG

26

ISAVVSGIGGIVSYNNDCLG

45

17.5%

NZ_AKXV01000031.1and 1 other:

NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06200_lanthipeptide

Lanthipeptides: Y19_RS0109830_lanthipeptide

31

VNGWQETP

38

VNGWQE P

10

VNGWQEKP

17

15.1%

NZ_NNBP01000002.1:

Lanthipeptides: allorf_467447_467647_lanthipeptide

19

DRCLGAPAVCGPVNGWQETPDD

40

+R P GP WQ P D

30

NRSNAEPRSAGPQRRWQTEPSD

51

15.0%

NZ_KQ948355.1:

Lanthipeptides: allorf_092130_092306_lanthipeptide

14

VVLAEDRCLGAPAV

27

+AE RC G P+

16

TAIAERRCTGRPSA

29

allorf_113840_114058

Leader:

MLRRGPAPGQRGSPPTASCALAACDRHHASLGA

Core:

EYGSASGGEEPGPMAASGQPGAASGPTGRFLRVSRCGPW

Core with dehydrations:

EYGDhaADhaGGEEPGPMAADhaGQPGAADhaGPDhbGRFLRVDhaRCysGPW

antiSMASH-DB 4.0 matches for allorf_113840_114058

100.0%

NZ_JABBGE010000004.1:

Lanthipeptides: allorf_113840_114058_lanthipeptide

1

EYGSASGGEEPGPMAASGQPGAASGPTGRFLRVSRCGPW

39

EYGSASGGEEPGPMAASGQPGAASGPTGRFLRVSRCGPW

1

EYGSASGGEEPGPMAASGQPGAASGPTGRFLRVSRCGPW

39

23.1%

NZ_CP040439.1:

Lanthipeptides: allorf_1863394_1863579_lanthipeptide

8

GEEPGPMAASGQPGAASGPT

27

G+ GP+ GQP A G T

6

GDRAGPVRRCGQPAALDGRT

25

20.5%

NZ_CP041244.1:

Lanthipeptides: allorf_9024730_9024906_lanthipeptide

19

QPGAASGPT

27

QPGA SGPT

4

QPGALSGPT

12

with 1 more sequence matches

15.4%

NZ_GL882519.1:

Lanthipeptides: allorf_34528_34668_lanthipeptide

26

PTGRFLRVSRCG

37

+ R +RVSRC

4

DSKREMRVSRCS

15

allorf_118441_118560

Leader:

MRVRTGGAASSRRRAPREIGG

Core:

GPGMTDGRGCTRVISTSR

Core with dehydrations:

GPGMDhbDGRGCysDhbRVIDhaDhbDhaR

antiSMASH-DB 4.0 matches for allorf_118441_118560

100.0%

NZ_JABBGE010000004.1:

Lanthipeptides: allorf_118441_118560_lanthipeptide

1

GPGMTDGRGCTRVISTSR

18

GPGMTDGRGCTRVISTSR

1

GPGMTDGRGCTRVISTSR

18

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.34 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.85 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.31 out of 23.79

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 24.85 out of 30.12

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.96 out of 26.85

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.36 out of 27.04

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.66 out of 30.12

Confidence: medium

Additional weak hits (17):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.94 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.74 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.69 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.02 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.63 out of 32.74

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.20 out of 20.97

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.48 out of 31.73

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.13 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.19 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.75 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.82 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.24 out of 36.53

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.32 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.26 out of 29.65

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.60 out of 28.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

Lanthipeptides

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Core peptide predictions

HHL19_RS13545 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 3141.4 Da

Molecular weight: 3143.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3161.5 Da N = 1; 3179.5 Da N = 2; 3197.5 Da N = 3

HHL19_RS13570 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 2691.3 Da

Molecular weight: 2693.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2711.1 Da N = 1; 2729.1 Da N = 2; 2747.2 Da N = 3; 2765.2 Da N = 4; 2783.2 Da N = 5; 2801.2 Da N = 6; 2819.2 Da N = 7

HHL19_RS13545 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 3141.4 Da

Molecular weight: 3143.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3161.5 Da N = 1; 3179.5 Da N = 2; 3197.5 Da N = 3

HHL19_RS13570 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 2691.3 Da

Molecular weight: 2693.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2711.1 Da N = 1; 2729.1 Da N = 2; 2747.2 Da N = 3; 2765.2 Da N = 4; 2783.2 Da N = 5; 2801.2 Da N = 6; 2819.2 Da N = 7

HHL19_RS13610 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 3779.8 Da

Molecular weight: 3782.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3800.2 Da N = 1; 3818.2 Da N = 2

allorf_113840_114058 - Class II

Cleavage pHMM score: -1.60

RODEO score: 0

Monoisotopic mass: 3725.8 Da

Molecular weight: 3728.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3746.0 Da N = 1; 3764.1 Da N = 2; 3782.1 Da N = 3; 3800.1 Da N = 4; 3818.1 Da N = 5

allorf_118441_118560 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 1759.9 Da

Molecular weight: 1761.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1779.0 Da N = 1; 1797.0 Da N = 2; 1815.0 Da N = 3; 1833.1 Da N = 4

Predicted core structure(s)

For candidate cluster 5, location 88987 - 167757:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Acetyl-CoA) + (ohmal)
Non-colinear ordering:: HHL19_RS13665 + HHL19_RS13670

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 111170 - 159081:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Acetyl-CoA) + (ohmal)
Non-colinear ordering:: HHL19_RS13665 + HHL19_RS13670

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 119139 - 167757:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Acetyl-CoA) + (ohmal)
Non-colinear ordering:: HHL19_RS13665 + HHL19_RS13670

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HHL19_RS13535: X

AMP-binding (46..444): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ATFPFTFGLGGVFTVSAGEINGLGTTELLHIVLA
Nearest Stachelhaus code(s):: Ala DVGFVAGVLK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

HHL19_RS13645: X

AMP-binding (28..415): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RWGAFDFSVWEAHFFCGGAFNQYGPTETCIDSTT
Nearest Stachelhaus code(s):: Glu DVWHFGRINK (68% 8Å match); Gln DAWQFGLIDK (65% 8Å match); His DYWHFGAVDK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

HHL19_RS13665: Acetyl-CoA

CAL_domain (199..602): Acetyl-CoA

minowa: Acetyl-CoA

Prediction, score:

Acetyl-CoA: 20.6
AHBA: 8.3
shikimic_acid: 7.5
NH2: 3.1
fatty_acid: 0.0

HHL19_RS13670: mal

PKS_AT (541..825): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 143.0
inactive: 87.5
Methoxymalonyl-CoA: 84.0
Methylmalonyl-CoA: 65.5
Isobutyryl-CoA: 48.0
Propionyl-CoA: 47.5
Ethylmalonyl-CoA: 35.6
Benzoyl-CoA: 27.5
3-Methylbutyryl-CoA: 25.4
2-Methylbutyryl-CoA: 23.7
fatty_acid: 23.1
Acetyl-CoA: 19.9
CHC-CoA: 19.7
trans-1,2-CPDA: 17.5

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor
IolR	Regulator of the inositol catabolism
OsdR	Development and stress management regulator
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JABBGE010000004.1 - Region 3 - RiPP-like

Download region GenBank file

Download region SVG

Location: 180,887 - 192,518 nt. (total: 11,632 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HHL19_RS13795: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Hydrolases: deacetylase

HHL19_RS13840: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000541.5	0.33	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001889.2	0.33	ribosomal	fusilassin	Thermobifida fusca YX
BGC0000351.5	0.33	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000498.5	0.32	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.32	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0001363.5	0.32	NRPS, PKS	ralsolamycin	Ralstonia solanacearum GMI1000
BGC0002663.2	0.32	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000306.5	0.31	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0000565.5	0.31	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001928.2	0.31	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000541.5	0.33	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001889.2	0.33	ribosomal	fusilassin	Thermobifida fusca YX
BGC0000351.5	0.33	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000498.5	0.32	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.32	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0001363.5	0.32	NRPS, PKS	ralsolamycin	Ralstonia solanacearum GMI1000
BGC0002663.2	0.32	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000306.5	0.31	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0000565.5	0.31	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001928.2	0.31	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.01 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 17.84 out of 35.63

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 17.66 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JABBGE010000004.1 - Region 4 - butyrolactone

Download region GenBank file

Download region SVG

Location: 307,254 - 318,207 nt. (total: 10,954 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HHL19_RS14350: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Lyases: dehydratase

HHL19_RS14365: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.79	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.79	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0000244.4	0.52	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0002578.2	0.44	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000783.3	0.41	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000706.3	0.41	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000914.5	0.37	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000003.3	0.37	PKS	AF-toxin	Alternaria alternata
BGC0001458.4	0.36	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.79	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.79	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0000244.4	0.52	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0002578.2	0.44	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000783.3	0.41	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0000706.3	0.41	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000914.5	0.37	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000003.3	0.37	PKS	AF-toxin	Alternaria alternata
BGC0001458.4	0.36	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.22 out of 26.85

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.00 out of 29.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JABBGE010000004.1 - Region 5 - cyanobactin

Download region GenBank file

Download region SVG

Location: 439,305 - 461,899 nt. (total: 22,595 nt) Show pHMM detection rules used

cyanobactin: (cyanobactin_synth or TIGR03678 or cyanobactin_precursor)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HHL19_RS15045: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Hydrolases: phosphatase

HHL19_RS15040: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000249.5	0.48	PKS	nogalamycin	Streptomyces nogalater
BGC0001632.3	0.47	ribosomal	kawaguchipeptin A	Microcystis aeruginosa NIES-88
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002151.2	0.44	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002150.2	0.44	ribosomal	triculamin	Streptomyces triculaminicus
BGC0000500.5	0.43	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000243.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0002629.2	0.40	ribosomal	limnothamide	Limnothrix sp. CACIAM 69d
BGC0001167.4	0.39	ribosomal	piricyclamide 7005E1, piricyclamide 7005E2, piricyclamide 7005E3, piricyclamide 7005E4	Microcystis aeruginosa PCC 7005

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000249.5	0.48	PKS	nogalamycin	Streptomyces nogalater
BGC0001632.3	0.47	ribosomal	kawaguchipeptin A	Microcystis aeruginosa NIES-88
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002151.2	0.44	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002150.2	0.44	ribosomal	triculamin	Streptomyces triculaminicus
BGC0000500.5	0.43	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000243.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0002629.2	0.40	ribosomal	limnothamide	Limnothrix sp. CACIAM 69d
BGC0001167.4	0.39	ribosomal	piricyclamide 7005E1, piricyclamide 7005E2, piricyclamide 7005E3, piricyclamide 7005E4	Microcystis aeruginosa PCC 7005

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.53 out of 21.84

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.49 out of 31.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.29 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JABBGE010000004.1 - Region 6 - terpene

Download region GenBank file

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Location: 582,678 - 609,147 nt. (total: 26,470 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HHL19_RS15715: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

HHL19_RS15750: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: aminotransferase transferase

HHL19_RS15710: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

HHL19_RS15775: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Ligases: synthetase

HHL19_RS15755: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.70	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002610.3	0.49	terpene	stellatic acid	Aspergillus stellatus
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.70	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002610.3	0.49	terpene	stellatic acid	Aspergillus stellatus
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

HHL19_RS15740: PT_phytoene_like

Domain 1 (19 - 274): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

HHL19_RS15745: PT_phytoene_like

Domain 1 (14 - 305): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → squalene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

HHL19_RS15755: PT_FPPS_like

Domain 1 (73 - 365): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

HHL19_RS15760: T2TS

Domain 1 (25 - 657): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (7):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.39 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.72 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.33 out of 24.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.66 out of 29.65

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.44 out of 23.43

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.58 out of 29.65

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description

NZ_JABBGE010000005.1 - Region 1 - lassopeptide

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Location: 24,840 - 47,371 nt. (total: 22,532 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

HHL19_RS16440: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

HHL19_RS16485: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001493.5	0.49	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0002571.2	0.29	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0001719.4	0.25	PKS	olimycin A, olimycin B	Streptomyces olivaceus
BGC0000075.5	0.23	PKS	hygrocin A, hygrocin B	Streptomyces sp. LZ35
BGC0000001.5	0.23	PKS	abyssomicin C, atrop-abyssomicin C	Verrucosispora maris AB-18-032
BGC0001088.5	0.23	NRPS, PKS	albicidin	Xanthomonas albilineans
BGC0001558.5	0.22	PKS	cosmomycin C	Streptomyces sp. CNT302
BGC0001740.5	0.21	NRPS, PKS	phthoxazolin	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001493.5	0.49	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0002571.2	0.29	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0001719.4	0.25	PKS	olimycin A, olimycin B	Streptomyces olivaceus
BGC0000075.5	0.23	PKS	hygrocin A, hygrocin B	Streptomyces sp. LZ35
BGC0000001.5	0.23	PKS	abyssomicin C, atrop-abyssomicin C	Verrucosispora maris AB-18-032
BGC0001088.5	0.23	NRPS, PKS	albicidin	Xanthomonas albilineans
BGC0001558.5	0.22	PKS	cosmomycin C	Streptomyces sp. CNT302
BGC0001740.5	0.21	NRPS, PKS	phthoxazolin	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.28 out of 27.55

Confidence: medium

Additional weak hits (8):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.11 out of 26.33

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.13 out of 36.53

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.31 out of 27.04

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.29 out of 32.93

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.08 out of 27.04

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.84 out of 21.84

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 4 - 85; Score: 37.0

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes

NZ_JABBGE010000005.1 - Region 2 - terpene

Download region GenBank file

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Location: 102,092 - 124,344 nt. (total: 22,253 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

HHL19_RS16845: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.82	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0000658.3	0.56	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001972.4	0.34	other (other)	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0000711.5	0.28	saccharide	neomycin	Streptomyces fradiae
BGC0000709.5	0.28	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0000143.5	0.27	PKS	salinomycin	Streptomyces albus
BGC0002657.2	0.24	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0001334.5	0.23	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0001828.5	0.22	PKS	griseochelin	Streptomyces griseus
BGC0001203.4	0.21	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.82	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0000658.3	0.56	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001972.4	0.34	other (other)	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0000711.5	0.28	saccharide	neomycin	Streptomyces fradiae
BGC0000709.5	0.28	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0000143.5	0.27	PKS	salinomycin	Streptomyces albus
BGC0002657.2	0.24	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0001334.5	0.23	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0001828.5	0.22	PKS	griseochelin	Streptomyces griseus
BGC0001203.4	0.21	NRPS, PKS	Clarexpoxcin A, Clarexpoxcin B, Clarexpoxcin C, Clarexpoxcin D, Clarexpoxcin E	uncultured bacterium AR_456

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

HHL19_RS16845: T1TS + T1TS

Domain 1 (2 - 326): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Domain 2 (327 - 701): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.07 out of 27.04

Confidence: medium

Additional weak hits (2):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.36 out of 21.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.06 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor

NZ_JABBGE010000005.1 - Region 3 - lanthipeptide-class-v,terpene

Download region GenBank file

Download region SVG

Location: 385,646 - 429,148 nt. (total: 43,503 nt) Show pHMM detection rules used

lanthipeptide-class-v: (APH and HopA1)
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

HHL19_RS18180: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

HHL19_RS18200: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: phosphotransferase

HHL19_RS38135: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: amidase hydrolase protease

HHL19_RS18075: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

HHL19_RS18110: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

HHL19_RS18130: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

HHL19_RS18215: amidase

smcogs: SMCOG1105: amidase

Lyases: cyclase

HHL19_RS18160: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: ligase synthetase

HHL19_RS18175: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

HHL19_RS18195: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter

HHL19_RS18065: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.45	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000673.3	0.40	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0000595.3	0.30	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000597.4	0.30	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000528.5	0.29	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000517.4	0.29	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001137.5	0.29	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0001227.3	0.28	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000282.3	0.27	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001050.5	0.26	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000673.3	0.53	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0000622.5	0.50	ribosomal	megacin	Bacillus megaterium
BGC0000597.4	0.49	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000517.4	0.48	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000595.3	0.46	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000516.4	0.46	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002514.3	0.46	PKS	julichrome Q6.6	Streptomyces sampsonii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

HHL19_RS18175: PT_FPPS_like

Domain 1 (37 - 320): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 22.09 out of 23.43

Confidence: strong

Additional weak hits (6):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.35 out of 32.74

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.62 out of 27.78

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.72 out of 26.12

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.81 out of 28.14

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.37 out of 18.57

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.32 out of 28.19

Confidence: weak

Lanthipeptides

Terpene

TFBS Finder

Core peptide predictions

No core peptides found.

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator

NZ_JABBGE010000006.1 - Region 1 - terpene-precursor

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Location: 20,637 - 41,692 nt. (total: 21,056 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

TTA codons

binding site

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Gene overview

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MIBiG comparison

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SubClusterBlast

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: transferase

HHL19_RS19210: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: dehalogenase

HHL19_RS19255: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Ligases: synthetase

HHL19_RS19240: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002531.3	0.39	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0001456.3	0.39	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002115.3	0.37	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001227.3	0.37	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000678.5	0.37	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002531.3	0.39	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0001456.3	0.39	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002115.3	0.37	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001227.3	0.37	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000678.5	0.37	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

HHL19_RS19240: PT_FPPS_like

Domain 1 (45 - 349): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.43 out of 23.79

Confidence: medium

Additional weak hits (6):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.44 out of 30.22

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.13 out of 27.55

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.58 out of 23.43

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.95 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.29 out of 36.54

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism

NZ_JABBGE010000006.1 - Region 2 - terpene

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Location: 376,693 - 397,955 nt. (total: 21,263 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

HHL19_RS20910: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: methyltransferase

HHL19_RS20865: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase dehydratase

HHL19_RS20870: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

HHL19_RS20905: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: transporter

HHL19_RS20840: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	0.86	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	0.79	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000657.5	0.64	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0001364.3	0.41	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002285.2	0.38	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001735.5	0.37	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001810.3	0.37	PKS	trehangelin	Polymorphospora rubra
BGC0000843.5	0.36	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0002666.2	0.35	NRPS, other (other)	Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B	Streptomyces sp. MA37
BGC0001556.5	0.35	NRPS, PKS	combamide	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	0.86	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	0.79	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000657.5	0.64	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0001364.3	0.41	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0002285.2	0.38	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001735.5	0.37	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001810.3	0.37	PKS	trehangelin	Polymorphospora rubra
BGC0000843.5	0.36	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0002666.2	0.35	NRPS, other (other)	Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B	Streptomyces sp. MA37
BGC0001556.5	0.35	NRPS, PKS	combamide	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene		2-methylisoborneol	C11	C1-C6	OH
monoterpene		2-methylenebornane	C11	C1-C6	none

Genes with terpene domains:

HHL19_RS20870: T1TS

Domain 1 (32 - 414): Type 1 terpene synthase

Subtype: 2-Methylisoborneol synthase type

Reactions:: 2-MeGPP → 2-methylisoborneol; 2-MeGPP → 2-methylenebornane

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 30.11 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.65 out of 30.11

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.65 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 30.11 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.65 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.65 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

Additional weak hits (5):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.44 out of 20.97

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.47 out of 29.65

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.09 out of 35.63

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.53 out of 26.85

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.91 out of 32.93

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
2-MeGPP	2-methylgeranyl diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
CelR	Cellobiose uptake repressor

NZ_JABBGE010000006.1 - Region 3 - T1PKS

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Location: 400,538 - 446,480 nt. (total: 45,943 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

HHL19_RS20995: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

HHL19_RS21010: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

HHL19_RS21060: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HHL19_RS21090: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

HHL19_RS20950: aminotransferase

smcogs: SMCOG1019: aminotransferase

Lyases: dehydratase hydratase

HHL19_RS21100: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

HHL19_RS21115: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: synthase

HHL19_RS21020: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.3	0.70	PKS	esperamicin	Actinomadura verrucosospora
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.61	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.60	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000107.3	0.59	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002043.3	0.55	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000056.3	0.70	PKS	esperamicin	Actinomadura verrucosospora
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.61	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.60	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000107.3	0.59	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002043.3	0.55	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (9):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.79 out of 30.22

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.18 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.17 out of 29.65

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.82 out of 20.01

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.61 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.02 out of 27.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.18 out of 32.93

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 400537 - 446480:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HHL19_RS21020: mal

PKS_AT (637..867): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 80.1
Methoxymalonyl-CoA: 45.1
Methylmalonyl-CoA: 44.6
Propionyl-CoA: 35.1
inactive: 34.6
Ethylmalonyl-CoA: 21.5
trans-1,2-CPDA: 21.1
fatty_acid: 13.5
Isobutyryl-CoA: 11.6
2-Methylbutyryl-CoA: 8.8
Acetyl-CoA: 1.8
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

NZ_JABBGE010000006.1 - Region 4 - lanthipeptide-class-ii

Download region GenBank file

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Location: 488,057 - 511,146 nt. (total: 23,090 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase methyltransferase

HHL19_RS21355: methyltransferase

smcogs: SMCOG1248: methyltransferase

HHL19_RS21360: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Lyases: cyclase

HHL19_RS21325: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.49	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000626.3	0.43	ribosomal	thuricin	Bacillus thuringiensis
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001407.5	0.41	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000502.5	0.40	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0002110.3	0.39	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002663.2	0.37	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.49	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000626.3	0.43	ribosomal	thuricin	Bacillus thuringiensis
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001407.5	0.41	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000502.5	0.40	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0002110.3	0.39	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002663.2	0.37	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for HHL19_RS21325

allorf_488911_489123

Leader:

MNHPQGAGHSPVNVAYM

Core:

LFTQSSPAVRVLHGSKPYFPSECTYPATFGDDHHVCRRTLVFLHESPAESAPT

Core with dehydrations:

LFDhbQDhaDhaPAVRVLHGDhaKPYFPDhaECysDhbYPADhbFGDDHHVCysRRDhbLVFLHEDhaPAEDhaAPDhb

antiSMASH-DB 4.0 matches for allorf_488911_489123

100.0%

NZ_JABBGE010000006.1:

Lanthipeptides: allorf_488911_489123_lanthipeptide

1

LFTQSSPAVRVLHGSKPYFPSECTYPATFGDDHHVCRRTLVFLHESPAESAPT

53

LFTQSSPAVRVLHGSKPYFPSECTYPATFGDDHHVCRRTLVFLHESPAESAPT

1

LFTQSSPAVRVLHGSKPYFPSECTYPATFGDDHHVCRRTLVFLHESPAESAPT

53

17.0%

NZ_CP019687.1and 1 other:

NZ_CP019717.1 Lanthipeptides: ERICV_RS20670_lanthipeptide

Lanthipeptides: BXP28_RS22835_lanthipeptide

8

AVRVLHGSKPYFPSECTYPATFGDD

32

A+ V K +FP C Y G D

14

ALEVKTAYKDWFPRMCEYGFEEGSD

38

16.4%

NZ_QTVL01000002.1and 2 others:

NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14275_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS03000_lanthipeptide

Lanthipeptides: DWZ44_RS04090_lanthipeptide

10

RVLHGSKPYFPSEC--TYPATFGDDHHV

35

++L +P+ SEC Y FG H+V

10

QILSYFQPFIKSECRREYKDEFGRIHYV

37

MIBiG 4.0 matches for allorf_488911_489123

9.4%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

23

CTYPATFGDDHHVC

36

C +FG VC

1

CRQSCSFGPFTFVC

14

allorf_504789_504947

Leader:

MGRGVWCGASQGAGA

Core:

PRTGSPLIERSRELGEGAMGAFRQRGEVPCQASRPRP

Core with dehydrations:

PRDhbGDhaPLIERDhaRELGEGAMGAFRQRGEVPCysQADhaRPRP

antiSMASH-DB 4.0 matches for allorf_504789_504947

100.0%

NZ_JABBGE010000006.1:

Lanthipeptides: allorf_504789_504947_lanthipeptide

1

PRTGSPLIERSRELGEGAMGAFRQRGEVPCQASRPRP

37

PRTGSPLIERSRELGEGAMGAFRQRGEVPCQASRPRP

1

PRTGSPLIERSRELGEGAMGAFRQRGEVPCQASRPRP

37

35.1%

NZ_JAPTYM010000001.1:

Lanthipeptides: allorf_00315602_00315700_lanthipeptide

22

FRQRGEVPCQASRPRP

37

FRQRGEVPCQ R RP

1

FRQRGEVPCQTPRTRP

16

31.0%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: allorf_098147_098374_lanthipeptide

Lanthipeptides: allorf_098147_098374_lanthipeptide

1

PRTGSPLIERSRELGEGAMGAFRQRGEVPCQASR

34

PRTG P R+R G +RGE C+ +R

2

PRTGRPRTVRARASG--------RRGERACRPAR

27

with 7 more sequence matches

28.2%

NZ_JABBXA010000002.1:

Lanthipeptides: allorf_494858_495019_lanthipeptide

17

GAMGAFRQRGEVP-CQASRPRP

37

A A + G +P CQASR RP

10

AATAALTRSGVLPACQASRWRP

31

27.0%

NZ_BMSK01000002.1:

Lanthipeptides: allorf_257175_257366_lanthipeptide

12

RELGEGAMGAFRQRGEVPC

30

R LG GA RQ GE C

2

RRLGPGARLRLRQHGEQRC

20

24.3%

NZ_CP026498.1:

Lanthipeptides: allorf_00224338_00224481_lanthipeptide

16

EGAMGAFRQR-GEVPCQ

31

G+ G R+R GEVPC+

3

NGSRGGVRRRPGEVPCE

19

19.6%

NZ_CP041244.1:

Lanthipeptides: allorf_9024962_9025201_lanthipeptide

14

LGEGAMGAFRQRGEVPCQAS

33

L GA G RGE PC+ +

2

LMTGARGGGFPRGEAPCRVT

21

19.6%

NZ_JALAPU010000003.1and 1 other:

NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS16960_lanthipeptide

Lanthipeptides: MOD17_RS07975_lanthipeptide

7

LIERSRELGEGAMGAFRQRGEVPCQASRPR

36

L +SR M Q+G V + RP+

2

LSNKSRHKVNKVMDYLEQQGFVELVSRRPK

31

19.6%

NZ_JALATU010000001.1and 1 other:

NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04580_lanthipeptide

Lanthipeptides: allorf_0125951_0126130_lanthipeptide

7

LIERSRELGEGAMGAFRQRGEVPCQASRPR

36

L +SR M Q+G V + RP+

2

LSNKSRHKVNKVMDYLEQKGFVELVSRRPK

31

18.9%

NZ_QOIL01000017.1:

Lanthipeptides: allorf_030196_030297_lanthipeptide

23

RQRGEVPCQASRP

35

R R + PC +SRP

5

RDRSKPPCGSSRP

17

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

Lanthipeptides

TFBS Finder

Core peptide predictions

allorf_488911_489123 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 5686.9 Da

Molecular weight: 5690.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5708.3 Da N = 1; 5726.3 Da N = 2; 5744.4 Da N = 3; 5762.4 Da N = 4; 5780.4 Da N = 5; 5798.4 Da N = 6; 5816.4 Da N = 7; 5834.5 Da N = 8; 5852.5 Da N = 9

allorf_504789_504947 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 3976.1 Da

Molecular weight: 3978.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3996.5 Da N = 1; 4014.5 Da N = 2; 4032.5 Da N = 3

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_JABBGE010000006.1 - Region 5 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 512,112 - 569,144 nt. (total: 57,033 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

HHL19_RS21475: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

HHL19_RS21555: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: formyltransferase kinase

HHL19_RS21415: acetylglutamate kinase

smcogs: SMCOG1174: acetylglutamate kinase

HHL19_RS21480: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Hydrolases: hydrolase protease

HHL19_RS21395: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

HHL19_RS21550: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: ligase

HHL19_RS21465: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002424.3	0.97	NRPS	saccharochelin A, saccharochelin B, saccharochelin C, saccharochelin D, saccharochelin E, saccharochelin F, saccharochelin G, saccharochelin H	Saccharothrix sp.
BGC0002135.2	0.85	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.82	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000349.5	0.78	NRPS	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.75	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.74	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002424.3	0.78	NRPS	saccharochelin A, saccharochelin B, saccharochelin C, saccharochelin D, saccharochelin E, saccharochelin F, saccharochelin G, saccharochelin H	Saccharothrix sp.
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000349.5	0.71	NRPS	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.03 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.71 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.48 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.90 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.73 out of 36.53

Confidence: medium

Additional weak hits (18):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.31 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.00 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 16.87 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.86 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 16.67 out of 36.54

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.23 out of 20.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 13.84 out of 21.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.21 out of 30.97

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.53 out of 39.62

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 13.83 out of 27.78

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.40 out of 36.53

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.00 out of 18.57

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.21 out of 31.73

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.25 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.71 out of 36.53

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.20 out of 28.19

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.40 out of 36.53

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 5, location 512111 - 569144:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Fo-OH-Orn - Ser - OH-Orn - OH-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HHL19_RS21465: Fo-OH-Orn - Ser - OH-Orn - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (469..866): Fo-OH-Orn

nrpys: Fo-OH-Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTAAFDVTVWDMILIVGTEVVAYGLTEASVNSTL
Nearest Stachelhaus code(s):: Fo-OH-Orn DVWIIGAVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1517..1937): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFCSGEHNLYGPTEAAVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (100% 8Å match); Ala or Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2688..3108): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: MNHVFDMSWEEWNVLLGGEYNLYGPTEYTINTLG
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3786..4186): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTAAFDVFAFEMILLVGTEICAYGLTEATVNSTL
Nearest Stachelhaus code(s):: OH-Orn DVFILGAVNK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor

NZ_JABBGE010000007.1 - Region 1 - lanthipeptide-class-iv

Download region GenBank file

Download region SVG

Location: 258,030 - 281,335 nt. (total: 23,306 nt) Show pHMM detection rules used

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HHL19_RS23060: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Lyases: cyclase

HHL19_RS23015: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000563.4	0.84	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.83	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001579.4	0.54	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001660.3	0.53	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000503.5	0.51	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.51	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001779.5	0.49	ribosomal	siamycin	Streptomyces nodosus
BGC0000884.5	0.43	other (other)	3-methylarginine	Pseudomonas syringae pv. syringae
BGC0001920.4	0.42	ribosomal	siamycin I	Streptomyces sp.
BGC0000521.3	0.42	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000563.4	0.84	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.83	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001579.4	0.54	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001660.3	0.53	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000503.5	0.51	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.51	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001779.5	0.49	ribosomal	siamycin	Streptomyces nodosus
BGC0000884.5	0.43	other (other)	3-methylarginine	Pseudomonas syringae pv. syringae
BGC0001920.4	0.42	ribosomal	siamycin I	Streptomyces sp.
BGC0000521.3	0.42	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.79 out of 25.75

Confidence: medium

Additional weak hits (8):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.70 out of 29.51

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.65 out of 32.74

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.08 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.16 out of 27.78

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.66 out of 32.74

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.72 out of 30.98

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.08 out of 27.18

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 16.96 out of 22.40

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
MatP	Cell cycle regulator

NZ_JABBGE010000007.1 - Region 2 - terpene

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Location: 395,537 - 416,673 nt. (total: 21,137 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HHL19_RS23655: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: methyltransferase

HHL19_RS23675: methyltransferase

smcogs: SMCOG1089: methyltransferase

HHL19_RS23700: methyltransferase

smcogs: SMCOG1248: methyltransferase

Lyases: cyclase

HHL19_RS23660: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.77	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0002568.2	0.42	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0001910.4	0.42	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001911.3	0.39	terpene	raimonol	Streptomyces anulatus
BGC0002567.2	0.38	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0001959.4	0.38	other (other)	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0002656.2	0.38	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0001197.5	0.38	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001483.4	0.38	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.77	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0002568.2	0.42	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0001910.4	0.42	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001911.3	0.39	terpene	raimonol	Streptomyces anulatus
BGC0002567.2	0.38	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0001959.4	0.38	other (other)	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0002656.2	0.38	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0001197.5	0.38	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001483.4	0.38	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

HHL19_RS23660: T1TS

Domain 1 (5 - 334): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72

Confidence: medium

Additional weak hits (11):

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.65 out of 19.26

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 13.73 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.44 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.57 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.99 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.88 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.22 out of 28.14

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.26 out of 30.22

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.50 out of 25.75

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.80 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.09 out of 32.93

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C

NZ_JABBGE010000008.1 - Region 1 - T1PKS

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Location: 363,594 - 423,689 nt. (total: 60,096 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase synthase

HHL19_RS25935: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HHL19_RS25940: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HHL19_RS25945: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

HHL19_RS25955: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

HHL19_RS25965: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HHL19_RS25985: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

HHL19_RS25995: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

HHL19_RS26020: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Hydrolases: synthase

HHL19_RS26020: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Lyases: hydratase

HHL19_RS25910: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Ligases: synthase

HHL19_RS25980: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HHL19_RS25990: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

HHL19_RS38215: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: permease

HHL19_RS25900: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.74	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001258.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.74	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001258.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.10 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.03 out of 26.85

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.25 out of 27.04

Confidence: strong

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.01 out of 27.04

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

Additional weak hits (15):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.08 out of 18.57

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.75 out of 36.54

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.66 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.73 out of 36.54

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.83 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.68 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.02 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.14 out of 36.54

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.39 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.68 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.41 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.40 out of 29.38

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.82 out of 27.55

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.65 out of 32.93

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.48 out of 24.78

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 363593 - 423689:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal) + (ohmal) + (pk)
Non-colinear ordering:: HHL19_RS25980 + HHL19_RS38215 + HHL19_RS25970

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HHL19_RS25970: pk

PKS_AT (570..867): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%; Methylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.9
Ethylmalonyl-CoA: 186.4
Methoxymalonyl-CoA: 149.2
2-Methylbutyryl-CoA: 142.7
trans-1,2-CPDA: 105.5
CHC-CoA: 96.3
Propionyl-CoA: 90.0
Isobutyryl-CoA: 87.0
Malonyl-CoA: 86.8
Benzoyl-CoA: 48.9
fatty_acid: 37.8
3-Methylbutyryl-CoA: 36.9
Acetyl-CoA: 31.1
inactive: 22.8

HHL19_RS38215: mal

PKS_AT (575..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 223.5
inactive: 118.5
Methoxymalonyl-CoA: 73.9
Methylmalonyl-CoA: 61.9
Propionyl-CoA: 44.9
Isobutyryl-CoA: 30.1
Ethylmalonyl-CoA: 26.0
Acetyl-CoA: 24.1
Benzoyl-CoA: 19.9
2-Methylbutyryl-CoA: 19.2
trans-1,2-CPDA: 17.7
fatty_acid: 16.1
CHC-CoA: 15.3
3-Methylbutyryl-CoA: 0.0

HHL19_RS25980: mal - mal

PKS_AT (535..839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.4
inactive: 120.1
Methoxymalonyl-CoA: 57.8
Methylmalonyl-CoA: 53.4
Propionyl-CoA: 32.8
Isobutyryl-CoA: 29.4
Acetyl-CoA: 27.7
trans-1,2-CPDA: 21.4
Ethylmalonyl-CoA: 20.1
Benzoyl-CoA: 18.0
2-Methylbutyryl-CoA: 14.9
fatty_acid: 8.6
CHC-CoA: 6.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (1776..2076): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.9
inactive: 119.7
Methoxymalonyl-CoA: 69.0
Methylmalonyl-CoA: 55.9
Propionyl-CoA: 32.8
Isobutyryl-CoA: 30.1
Acetyl-CoA: 25.0
Ethylmalonyl-CoA: 24.1
Benzoyl-CoA: 23.3
CHC-CoA: 16.9
2-Methylbutyryl-CoA: 15.8
fatty_acid: 15.6
trans-1,2-CPDA: 14.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DasR	N-acetylglucosamine dependent repressor
IolR	Regulator of the inositol catabolism
RutR	Regulator of the pyrimidine and purine metabolism
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_JABBGE010000009.1 - Region 1 - PKS-like,butyrolactone

Download region GenBank file

Download region SVG

Location: 231,364 - 272,422 nt. (total: 41,059 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)
butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

HHL19_RS27500: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

HHL19_RS27540: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HHL19_RS27585: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

HHL19_RS38260: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: aminotransferase

HHL19_RS27520: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Ligases: synthase

HHL19_RS27575: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

HHL19_RS37765: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.90	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.48	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.40	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.32	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001810.3	0.27	PKS	trehangelin	Polymorphospora rubra
BGC0002554.2	0.25	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0000676.5	0.24	terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0001080.5	0.24	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0001850.4	0.24	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0000286.3	0.24	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.75	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.57	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.54	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.48	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000858.3	0.47	other (other)	ectoine	Methylobacter marinus
BGC0001810.3	0.46	PKS	trehangelin	Polymorphospora rubra
BGC0000843.5	0.45	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate	Streptomyces clavuligerus ATCC 27064
BGC0002052.3	0.45	other (ectoine)	ectoine	Streptomyces sp.
BGC0000841.5	0.43	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0002554.2	0.42	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.24 out of 27.04

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.41 out of 27.04

Confidence: medium

Additional weak hits (5):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.72 out of 28.14

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 18.77 out of 33.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.75 out of 32.74

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.50 out of 20.97

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.45 out of 20.97

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor