LOCUS       NZ_JABBGE010000005     22532 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. R302 contig5, whole genome shotgun sequence.
ACCESSION   NZ_JABBGE010000005
VERSION     NZ_JABBGE010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. R302
  ORGANISM  Streptomyces sp. R302
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 635866)
  AUTHORS   Dahal,R.H.
  TITLE     Streptomyces sp. R302 sp. nov., isolated from soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 635866)
  AUTHORS   Dahal,R.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) Life Science, Kyonggi University, Kyonggi
            University, Suwon, Gyeonggi-Do 16227, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2020
            Assembly Method                   :: SPAdes v. APR-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012927245.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 03:52:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,357
            CDSs (total)                      :: 7,271
            Genes (coding)                    :: 7,075
            CDSs (with protein)               :: 7,075
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 1, 1, 3 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 84 of 196
            Pseudo Genes (incomplete)         :: 164 of 196
            Pseudo Genes (internal stop)      :: 20 of 196
            Pseudo Genes (multiple problems)  :: 67 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:44:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 24839
            Orig. end                         :: 47371
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBGE010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22532
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22532
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22532
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12532](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12532)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    166..178
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            complement(175..984)
                     /gene="istB"
                     /locus_tag="HHL19_RS16370"
                     /old_locus_tag="HHL19_16375"
     CDS             complement(175..984)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="istB"
                     /gene_functions="other (smcogs) SMCOG1151: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526976.1"
                     /locus_tag="HHL19_RS16370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16375"
                     /product="IS21-like element helper ATPase IstB"
                     /protein_id="WP_346768582.1"
                     /transl_table=11
                     /translation="MSTSPMQMSEARRFQQLRGHLSYLKLNDAAEALNRVLDQARTERM
                     SLTAALERLLEIEVEATEARRLAARLRFACLPEPWTLNDFDFAAQPGVDEKLIRDLATL
                     RFLDDASNVLFVGPPGVGKTMLSVALGRAAVDAGHRVYFTTAAELAAKCHKAALEGRWK
                     TCMRFFAGPKLLIIDELGYLPLPEDGASALFQVINQRYLKSSTILTTNVGIADWAGAFG
                     DATVAAAMLDRLLHRAAVAGIDGPSYRLRNHQTQADTIRKGVNARVS"
     gene            complement(981..2342)
                     /locus_tag="HHL19_RS16375"
                     /old_locus_tag="HHL19_16380"
     CDS             complement(981..2342)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1213: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114933.1"
                     /locus_tag="HHL19_RS16375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16380"
                     /product="DDE-type integrase/transposase/recombinase"
                     /protein_id="WP_169090231.1"
                     /transl_table=11
                     /translation="MLTREEDVDAHALRRQGWTISAIARHLGRDRKTIRAYLNGDQVPG
                     QRRQSPDAFVPFLQYCRQRLADDPHLWASTLFDEVRDLGYEGGYSTFTRALRRYQVRPH
                     CEPCHAATGRNVAVIAHPPGEEIQFDWLELPDAPESWGVGEHAHLLVGALAHSGRWRAV
                     LAESEDFPHLVQALDQVVRKLGGTARRWRFDRMATVCYPSSGQVTASFAAVAKYYGVGV
                     DICPPRRGNRKGVVEKANHSAAQRWWRTVPDALTVVQAQSGIDKLAVRMDERRRSVDGI
                     KVTVGELAAAEMLLDVPVRPFPAELEVERTVSPQCLVSFDGNLYSVPPGLAGTQVRVLH
                     RLGENHLDIATAGRAVVARHRRAPRGSGQTVRDAGHVLALEREVLASFSDRAPCKNKVR
                     RPPSEAARAEAERLRGQQAAAGDPAERVVIDLSHYAAVADRLRTVPSPKEENTE"
     misc_feature    complement(2307..2320)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     gene            complement(2486..2761)
                     /locus_tag="HHL19_RS16380"
                     /old_locus_tag="HHL19_16385"
     CDS             complement(2486..2761)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16385"
                     /product="hypothetical protein"
                     /protein_id="WP_169090233.1"
                     /transl_table=11
                     /translation="MLLLAGQSGPAAGAVFLLIWGLAVIFVGGAFATKRGAAGIRSLIV
                     NGLERASRQQAEARAVSEGFVRFVGGFLAICGMVAVPISVVMLTRG"
     misc_feature    complement(2841..2859)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.13"
                     /tool="antismash"
     gene            2920..3372
                     /locus_tag="HHL19_RS16385"
                     /old_locus_tag="HHL19_16390"
     CDS             2920..3372
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16390"
                     /product="hypothetical protein"
                     /protein_id="WP_169090234.1"
                     /transl_table=11
                     /translation="MRRGDQLAQLLGLAARPDDPHLPVVAQAVLTELDAPVRQLTEYAT
                     LTGQPEAVALLHLATTLTTDSGDGDDITVGLQWIARRLETVRPHGEMTPAARRALADRA
                     GIDRHGFGNPASHALTEALLQHLPTPTAGINRADYAATIPTIGAAR"
     gene            3369..4658
                     /locus_tag="HHL19_RS16390"
                     /old_locus_tag="HHL19_16395"
     CDS             3369..4658
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16395"
                     /product="DUF2637 domain-containing protein"
                     /protein_id="WP_169090236.1"
                     /transl_table=11
                     /translation="MNNRAWTASRVVVSVAALITAGWSLYAVSRHYGAPILIAGASVAV
                     FDGIAYGCQYLATVASTAGRSGFGARLAALFMVGVSVALNIKHAQLIAGGPTAALLFAV
                     PSIGLLAIAELDWAGGRADARTARGEQPYRLPAYGGWAWLLAPRTAAQSVRTAALAHIQ
                     HTHTNDQPLLSGQSGPSPDTALTKTGTDAVREYFAMVNPIDAIHVAHNSQPALSSAELA
                     SLLVSYGVPVDQVQVDIVLGRRGPAGNVERSGALPAPGPQPELVAAQSGPSGLAPDPLR
                     VALAQLQDRFAAMDPGEVIRIIDKLQPALSSQRLADLLADYGLNVTRPAVDLALRRPQA
                     ELLAVLSGQSGSGPAAATATTAVEALIEYGVRDVDLAIPAVCAHLGPAVREDTVRRLFD
                     RKVKPIREAETAQTTEAAEADSIGKGGGYN"
     gene            4739..5431
                     /locus_tag="HHL19_RS16395"
                     /old_locus_tag="HHL19_16400"
     CDS             4739..5431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566363.1"
                     /locus_tag="HHL19_RS16395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16400"
                     /product="hypothetical protein"
                     /protein_id="WP_169090238.1"
                     /transl_table=11
                     /translation="MRIRTGHASREGTREDNADAATVHQLSTGAIGAAVIDGIGHGPRT
                     SDTAPLLAAVAARTTAHRGPLAGLLTAGLLISDPGYDDNEANAVGVAAALEPLDALFRI
                     AWVGDCRAYGWSHEAGLRNYTTDHTVGEQLRRNGAPWDLAADHDNWIRTSLGDATVASV
                     YEVLIPDGLVILTSDGVHDYVEHGHLEDLVREHATDPQALADVLVSAGEWGTGGYRDDA
                     TAVVLRRG"
     gene            5439..5906
                     /locus_tag="HHL19_RS16400"
                     /old_locus_tag="HHL19_16405"
     CDS             5439..5906
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039693.3"
                     /locus_tag="HHL19_RS16400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16405"
                     /product="DUF6221 family protein"
                     /protein_id="WP_169090240.1"
                     /transl_table=11
                     /translation="MEALIAFLQARLDEDAAAAHAATPGPWWYHPGKQWLEGESFESYD
                     LTKGLEFVGYGGPHPFTGAVAGTGPADHPQSMADAAHIARHDPARALRGAEALRSLLHA
                     YEHPETSPELPDSVNTLTTAIQRQVLEKALRLLAIAYNDHPDYRPEWAPTT"
     gene            5917..6264
                     /locus_tag="HHL19_RS37285"
     CDS             5917..6264
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS37285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_240981643.1"
                     /transl_table=11
                     /translation="MSERVNVKVLLLIGREAEIVADADDATTPERYPAVEIAAAVSLPE
                     GQLPGTRLTARVGAGHRLFDWRLASDQRPTAGGRTPTPIVELTAPASGALGERITDHLG
                     TAHRLLGESPA"
     gene            6419..6793
                     /locus_tag="HHL19_RS16410"
                     /old_locus_tag="HHL19_16415"
     CDS             6419..6793
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16415"
                     /product="hypothetical protein"
                     /protein_id="WP_169090242.1"
                     /transl_table=11
                     /translation="MSDQRDEILAHIAHDLSLTYSKLAMACGNLPVPVAIPTGSVSNVE
                     AIPAVRRVAELAEDVTMPVDQQAQLFASCCFWLGAMDIYGLLFASFHDVRAHSALANLI
                     MANESLEDLLAWLRAHTEMK"
     gene            6946..7341
                     /locus_tag="HHL19_RS16415"
                     /old_locus_tag="HHL19_16420"
     CDS             6946..7341
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143004.1"
                     /locus_tag="HHL19_RS16415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16420"
                     /product="hypothetical protein"
                     /protein_id="WP_169090244.1"
                     /transl_table=11
                     /translation="MVNTPPASETLSEIAARHGRSEKTIRNTWARHPDWPAAVGKRGRA
                     YVYDPAAVDQVVADHFARPAADLEPRRLYTTAEIATATGLKAVTIRAEVSKGRWPAADD
                     TAGRVHRWYGSTVLKALQDRRGYRSTD"
     misc_feature    7883..7899
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.28"
                     /tool="antismash"
     gene            7989..8360
                     /locus_tag="HHL19_RS16420"
                     /old_locus_tag="HHL19_16425"
     CDS             7989..8360
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16425"
                     /product="hypothetical protein"
                     /protein_id="WP_169090245.1"
                     /transl_table=11
                     /translation="MSDQYDEDIQKVGAALIATYDILVRVCLRLPIPVTLPTGPLLDSA
                     ELIPAVARVVDLMEEMPASTDLKLSVFTASLNWLAAGKLFSRYLDHPEDTTAKPEIELI
                     LCGAAEALANAAALLHTED"
     gene            complement(8899..9918)
                     /locus_tag="HHL19_RS16425"
                     /old_locus_tag="HHL19_16430"
     CDS             complement(8899..9918)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="HHL19_RS16425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16430"
                     /product="protein-L-isoaspartate(D-aspartate)
                     O-methyltransferase"
                     /protein_id="WP_169090247.1"
                     /sec_met_domain="PCMT (E-value: 3.1e-13, bitscore: 45.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVVAEAADTVPERHYTHHDGRGETPHRSAPRVIHRELTSLDVQP
                     GMKVIEHGTGSGYSGALLAQLVGGTGSVTSLDIDPYLVSWANLIHHQQADFHVRCYLAD
                     DPARAAHAPFHRTVAWCTPPLLPAEWVAQSTDEAVIVTPLPVAELPHMTAVVKVRVSGG
                     KPVVEEVFHGEYVDATTSPKQDLDAPGRWVDWETRVPAPAWISIGWRDRDDRLRSGARA
                     TLERLQDPGAHTGTYAGGALPWASFQAFVAAQADPQLTVGAVRGGRWAIGHSTPTSAAV
                     IEENGTIFADAPGSASLAVLRRWLGAWEEAARPAVESYSATLVPVFDGPEPGWRLRLA"
     gene            complement(10001..10423)
                     /locus_tag="HHL19_RS16430"
                     /old_locus_tag="HHL19_16435"
     CDS             complement(10001..10423)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="HHL19_RS16430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16435"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_240981644.1"
                     /sec_met_domain="PF13471 (E-value: 2e-15, bitscore: 52.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSMEAYSTSRTGSTVERAAAVVGFAAALVLLRFPFRRTARAVRI
                     ARWLGRRPVAPARAEAVVEAVRHAARWWPGRAACLETSLSAVLAVALLGGRLDWCVGAR
                     FVPPPVEYHAWVELPGHGPVGEYTAGGWHHLPALKI"
     gene            complement(10420..10719)
                     /locus_tag="HHL19_RS16435"
                     /old_locus_tag="HHL19_16440"
     CDS             complement(10420..10719)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="HHL19_RS16435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16440"
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_169090249.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 8.3e-11,
                     bitscore: 37.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVWQLCEHAHPVLTDEGGAILDEHTGRWQYLSPTSSAAVLLLLA
                     GPGREQAVERYAARYSIGRERAAADVGEVAGSLVRLGLAHDGAPEPAQRRWWSR"
     aSDomain        complement(10465..10707)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHL19_RS16435_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.90E-12"
                     /identifier="RREFam002.1"
                     /label="HHL19_RS16435"
                     /locus_tag="HHL19_RS16435"
                     /protein_end="85"
                     /protein_start="4"
                     /score="37.0"
                     /tool="antismash"
                     /translation="QLCEHAHPVLTDEGGAILDEHTGRWQYLSPTSSAAVLLLLAGPGR
                     EQAVERYAARYSIGRERAAADVGEVAGSLVRLGLAH"
     gene            complement(10697..12532)
                     /locus_tag="HHL19_RS16440"
                     /old_locus_tag="HHL19_16445"
     CDS             complement(10697..12532)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033561.1"
                     /locus_tag="HHL19_RS16440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16445"
                     /product="albusnodin/ikarugamycin family macrolactam
                     cyclase"
                     /protein_id="WP_169090251.1"
                     /sec_met_domain="Asn_synthase (E-value: 4.7e-20, bitscore:
                     67.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRWSAGWSGGHSPVQRPAAGRPVTGFQHVWTAEWPHDRVLSTSVD
                     AAAVAVVGECAADEEHLLAGLRHVVAGRWAELTRWPGSYTVVARHGESTVIIGDLSGQH
                     PVYFRPETGGTWWSTAAIPLASLDGAPVDTTALAAHLAFGQPDVTGRRSLFRGVQRVPT
                     GSLLELTPSGARVVRYEPVAYEPVDLRTGAARVQAALRAAVALRADGRSVSADLAGLDS
                     TTLACLAAERGPVAAVTFADERLRDDDLTYAARTAMTVDSIRHRIAPGNAGTVYYAGLD
                     DLTHLPVTDAPSAYVVTAPIKRAVLDAVVEMNGPGGAHLTGVGGDGVLSAGAEYIADLL
                     RQRKGRRAWSHAQGHARLRRTSGIETFRRALPASRLDLPGGWLAVARELRADPRPWVPQ
                     AQRPVAWTPLLATADWMTRGARLMLASLLDDAAAEVDDAPDQLAVWTERQDLARVGADT
                     AGLRALARHGHGVDIAAPYLDSEVMRACLAVPAQQRGVPYEFKPLLGAAFKAGPVPSFV
                     LERRTKGGFNGVAYAGIQATAVRMRELLGPSSRLATMGLLTEQPVAEALARAVAGQPAP
                     QGAIHSAIAAEVWLRQLDAAAIGWWEEAGDRVAAV"
     gene            complement(12679..12819)
                     /locus_tag="HHL19_RS16445"
                     /old_locus_tag="HHL19_16450"
     CDS             complement(12679..12819)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014043657.1"
                     /locus_tag="HHL19_RS16445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16450"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_169090253.1"
                     /transl_table=11
                     /translation="MAQQITEVEIVTPAYEAPVVIAVGTVAEVTLGTQSFDTADDTQYK
                     H"
     misc_feature    12921..12936
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.31"
                     /tool="antismash"
     gene            12970..14250
                     /locus_tag="HHL19_RS16450"
                     /old_locus_tag="HHL19_16455"
     CDS             12970..14250
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009068302.1"
                     /locus_tag="HHL19_RS16450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16455"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_206325911.1"
                     /transl_table=11
                     /translation="MTTGDRIRTAREKRGWSQIRLAKELSTARWGVEDYLGRQQVYRWE
                     KGGRAPKDWRPFIEQVLDISLEINPTATIQTPDLDTVASVMQLGGTDVDRRTLLVATAA
                     ASLAALDLTDAEAVTRRVSKPGPVAVGAGDVSAVRIMTTTLGDAASELGGGHARHLAVR
                     YLTVDVKRLLDGRYTDKTGRDLFAAASELVHLIGWMARDEGDYGLSQRYNVHAYKLAAE
                     AGENELAATALRALADQAIDLGHIPTAVRLAEACEQRGRKLDNPKALAYYRNTLARALA
                     ADRDDTAAARLLTSAQTAIERAPARPGQSWASHYSHGRWAHESGMIHARMGDWSAAEEH
                     LRLALDIHGLDRKRTRAIVLADLGHVQVRRGNTQEALTTWDEFLDIADGIQSVRITDGL
                     TNIAARLSSLPPSGSQQELLERVSARL"
     misc_feature    13042..13044
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     tRNA            14471..14542
                     /anticodon=(pos:39342..39344,aa:Ser,seq:gct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HHL19_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HHL19_16460"
                     /product="tRNA-Ser"
     gene            14471..14542
                     /locus_tag="HHL19_RS16455"
                     /old_locus_tag="HHL19_16460"
     misc_feature    complement(14591..14604)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     gene            14644..16308
                     /locus_tag="HHL19_RS16460"
                     /old_locus_tag="HHL19_16465"
     CDS             14644..16308
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174384.1"
                     /locus_tag="HHL19_RS16460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16465"
                     /product="TROVE domain-containing protein"
                     /protein_id="WP_169090256.1"
                     /transl_table=11
                     /translation="MSRFNTRAARPRATSPVTTTGEHTATYEAATGYLRDSKSELYLLA
                     VHNRVATDTFYETGTTRDDRYRQLVRELAVLDPAWTASFLAWLRTHGNMRTAAIVGAAE
                     FVHARLHASKTAALRPGPIAVDIAPHSDRAVIASVLQRPDEPGELLGYWTTHYGRRLPQ
                     PLKRGIADATQRLYTERALLKYDTDSHGYRFGDVLELVHAAPAANRPWQGDLFKHAIDR
                     RHNRAEDVPAQLATIRARNDLHRVPVQERRALLAGGADRLAAAGMTWESLAGWLQGPLD
                     AAAWEAVIPSMGLMALARNLRNFDEAGVSDAVAQAVAARLADPDEVRRSRMFPFRVWAA
                     YKAAPNLRWAHPLEQALNHSLANVPALSGHTLILVDRSPSMFPGFYYSTANTSDISLAE
                     QAAIFGAALALRAENPTLVEFGGTSREITPKKGGSALPLVEQFGSIDGTDIPSAVKKHF
                     SGHDRVIVVTDEQTRPGWLPSNMISYQGMPETRIDDLIPASVPVYMWNMAGYRPGATPA
                     GGRNRHTLGGLSDAAFSLIPLLDAGRDARWPWEQADA"
     gene            complement(16539..17072)
                     /locus_tag="HHL19_RS16465"
                     /old_locus_tag="HHL19_16470"
     CDS             complement(16539..17072)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16470"
                     /product="hypothetical protein"
                     /protein_id="WP_169090258.1"
                     /transl_table=11
                     /translation="MIDPTSAAASAGTRAIASALLKKSPARLAPRLGGREERRGVYARY
                     SHAHADAASFAQALRMEKKFASTFMGQGRMRTLLAMTQERQTELLSAYLEVRLVANPGP
                     LAAADDLMSATSNLMDTGPSFDEHAFGAALEKALEAHRAFTDRCREDLWYAPRWWQLYR
                     VGWWSARWKWVRGK"
     misc_feature    17135..17153
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            17193..18023
                     /locus_tag="HHL19_RS16470"
                     /old_locus_tag="HHL19_16475"
     CDS             17193..18023
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16475"
                     /product="hypothetical protein"
                     /protein_id="WP_169090259.1"
                     /transl_table=11
                     /translation="MHTAPDVSDYEWPTCTNPRCGRALWPEEAHRHVCRPCEQTVNRLL
                     GELPALFVRLSTTSALLRRVGNRSAAASGRDTPPIPGRLEVLDLTGPGGAAARLQAIED
                     SWRAALGRRIGTWAGSPAQALPVHVTFLRINLEWACEQYAAVDQDLEVIRRLHRDCTTA
                     VSGTPRPAHVGIGTCPARDADGALCGEDLSATTAHHRIHCPRCGARWDGLADWRTLRRA
                     QEAAAASTALMDEEPTEFASQTLEKATAYTADDDDVETGELPVYAYSGGAWVQR"
     gene            18020..18457
                     /locus_tag="HHL19_RS16475"
                     /old_locus_tag="HHL19_16480"
     CDS             18020..18457
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039693.3"
                     /locus_tag="HHL19_RS16475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16480"
                     /product="DUF6221 family protein"
                     /protein_id="WP_169090261.1"
                     /transl_table=11
                     /translation="MTQQTRTPTGPTPAPVQLRLDVGEFLLARLLEARELAQAASPGTW
                     RSNEEHDEVLAVDDVTVADGFALSGRQLRATVDHIAHHHPVRVLADIAAKEELVREYLL
                     AARDPACRTDPAFHLQVHILRMVVTALARAYDDHPDYRSGW"
     gene            18542..18853
                     /gene="cutA"
                     /locus_tag="HHL19_RS16480"
                     /old_locus_tag="HHL19_16485"
     CDS             18542..18853
                     /GO_process="GO:0010038 - response to metal ion [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cutA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522485.1"
                     /locus_tag="HHL19_RS16480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16485"
                     /product="divalent cation tolerance protein CutA"
                     /protein_id="WP_169090263.1"
                     /transl_table=11
                     /translation="MQVSTATETEEQAIELASDAVRNRLAVGAQITKVKSVFWHHGEYG
                     TGEERQIRLKTTADRYPELEAYLLEAYPWDNPEVCAVPIVASAERWKQRIDTVVEEQR"
     gene            18936..19598
                     /locus_tag="HHL19_RS16485"
                     /old_locus_tag="HHL19_16490"
     CDS             18936..19598
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413183.1"
                     /locus_tag="HHL19_RS16485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16490"
                     /product="HAD family hydrolase"
                     /protein_id="WP_169090265.1"
                     /sec_met_domain="HAD_2 (E-value: 1.9e-13, bitscore: 46.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRAVVFDVGECLVDETREYGTWADWLGVPRHTFAAMFGAVIAQG
                     RDYRDVFQEFQPGFDLYEQREARAAAGQPEHFGEEDLYPDVRPALAQLRADGLWLGIAG
                     NQTTRAGKILRELFTEDVDFIGTSDDWGASKPDVEFFRRVAEVVPFENSEILYVGDRVD
                     NDLRPAVKAGMESALVRRGPWATIQWNTEEAEKLPTFRVESLAELSGNIIQFNGRGR"
     misc_feature    complement(18974..18989)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.08"
                     /tool="antismash"
     gene            complement(19579..20796)
                     /locus_tag="HHL19_RS16490"
                     /old_locus_tag="HHL19_16495"
     CDS             complement(19579..20796)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413185.1"
                     /locus_tag="HHL19_RS16490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16495"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_169090267.1"
                     /transl_table=11
                     /translation="MENDGNVLLRAARIAAGYGTQEALADAVGVAVRQVRRWESANPPW
                     PRDAVRRALTSLLGQNMEDLGFTPPDGIRAQRDGQPRELPRTRGMVTVPVPGVTLQPAT
                     AGEDFAEVTRRHRRLYWTVAPATLHPAIAAHTALGCALLPETAGIARRTVAAALAESFL
                     LAGRIQFFDSQEPDTAKETWTRALQAASQADDQLLGAAILAHSAFIPGWAGDRQAAVER
                     MTAARTYARRGEASAAFLAWLDAVEAECETRCGHTQTALSLLGHAEEVLTAGPDIPSPE
                     WMDWFSPVRLAAFKGHTQLTAGHLPQARETLLGVLDGLEPSEDKQRTVIFGDLAAVEAA
                     DRNPEKACEYAVAALEQLRRTWYSTGMDRVRDVRRALAPWQHERCVRDLDDRLYGWETT
                     VSALGR"
     misc_feature    complement(20955..20969)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            20981..21385
                     /locus_tag="HHL19_RS16495"
                     /old_locus_tag="HHL19_16500"
     CDS             20981..21385
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608116.1"
                     /locus_tag="HHL19_RS16495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16500"
                     /product="hypothetical protein"
                     /protein_id="WP_169090269.1"
                     /transl_table=11
                     /translation="MADPELLTTSKTESEPKTVGAEWDAIQVPRSVGLVALNILGARSG
                     AVIEDETALYWLLPAGSTEGWSTRGTKALPTGTTLDVPVARCTTGPGPHWRICPGEDRL
                     LTSVDALRAAVVDASGLAGGQPSPSGTAAR"
     gene            21424..21942
                     /locus_tag="HHL19_RS16500"
                     /old_locus_tag="HHL19_16505"
     CDS             21424..21942
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS16500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_16505"
                     /product="hypothetical protein"
                     /protein_id="WP_169090271.1"
                     /transl_table=11
                     /translation="MLVHSRSDREAGAETWLILAAHDKRQAQREWAEYGVALLRCGKTF
                     TAIRVPAEIVHAVAGTSDRDEVASYLATALDRGPCFFDGNSQSYYALAPRSAAGRWSVP
                     GTEALGGDFFLGVPATTITAPDPRCAAWWVVPMEGPAALCDVGIVRWLVERGRMRLAEV
                     RALEASEDA"
     gene            21935..22363
                     /locus_tag="HHL19_RS16505"
                     /old_locus_tag="HHL19_16510"
     CDS             21935..22363
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="HHL19_RS16505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_16510"
                     /product="ATP-binding protein"
                     /protein_id="WP_169090273.1"
                     /transl_table=11
                     /translation="MLDAPARRPEFFLTADEPSQSRTLRCDPMSVAVARRLVVAVLGRW
                     ELSEDLAERAELVVSELATNAIVHARTCGAPIRVAITRGEDDHIQVAVTDLDRRPLGPA
                     RTDPYAEGGRGLDLVAALSVRWGCERRRWGKRVWAELA"
ORIGIN
        1 gtgaagacgc cctggcagac agggcaagtg tggactgcag ggggtgaggg cgggagccgg
       61 tgggctgcgg acttgcagcg gggagaacag tagatctgtc gaggatgtgg cacgaactcg
      121 ccctggcgga cagggcagtt ggccgacaag ggggtgagtg aggtcgtgac gttgtcagga
      181 gacacgggcg ttcactccct tgcggatggt gtcggcctgg gtctggtgat tgcggagccg
      241 gtaggagggg ccgtcgatgc cggcgacggc tgcccggtgc aggagccggt cgagcatggc
      301 ggcagcgacg gtggcgtcgc cgaaggctcc ggcccagtcg gcgatgccga cgttggtcgt
      361 caggatcgtg ctcgacttca gatacctctg gttgatcacc tggaacagcg cggaggcacc
      421 gtcctcggga agcgggaggt agccgagctc gtcgatgatc aaaagcttcg gacctgcgaa
      481 gaagcgcatg caggtcttcc agcgtccttc gagggcggcc ttgtggcact tggccgcgag
      541 ctcggcggcg gtggtgaagt agacgcggtg tccggcgtcg accgcggccc ggccgagggc
      601 gacggacagc atggtcttgc cgacgccggg aggcccgacg aacaggacgt tggaggcgtc
      661 gtcgaggaag cgcagggtgg ccaggtcgcg gatgagtttc tcgtcgacac cgggctgggc
      721 ggcgaagtcg aagtcgttca gcgtccaggg ttcgggcagg caggcgaacc ggagacgagc
      781 cgcgagccga cgggcctcag tcgcctcgac ttcgatctcc aggagccgtt ccagtgcggc
      841 ggtcagcgac attcgctcgg tccgggcctg gtccagcact cggttgagtg cttcggcggc
      901 gtcgttgagt ttgaggtagg aaaggtggcc tcgcagctgc tggaagcggc gtgcttcgct
      961 catctgcatc ggggacgtac tcactccgtg ttctcctcct tcggtgaggg aacggtccgc
     1021 agccggtcgg ccacggcggc atagtgggac aggtcgatca cgacccgttc ggccggatca
     1081 ccagcggcgg cctgctgacc gcgcaaccgc tcggcctcgg cccgcgcggc ctcagaagga
     1141 ggcctgcgga ccttgttctt gcagggagcc cggtccgaga acgaggccag gacctctcgc
     1201 tcaagcgcga ggacatgccc ggcgtcccgc accgtctgac cggatccgcg cggcgcccgg
     1261 cggtggcggg caaccacggc ccgcccggca gtggcgatgt cgagatggtt ctcgccgagc
     1321 cggtgcagga ccctgacctg ggtgccggcg agtcccggcg ggacggaata cagattcccg
     1381 tcgaaggaca ccaggcactg cgggctcacg gtccgctcaa cctccagctc ggccgggaac
     1441 ggccggaccg ggacgtcgag caacatttcg gcggcagcga gttcaccgac ggtgaccttg
     1501 atcccgtcca ccgaccggcg gcgttcatcc atgcggactg cgagcttgtc gatgccggac
     1561 tgggcctgga cgacggtcag cgcgtcggga accgtgcgcc accagcgttg ggctgccgaa
     1621 tggttggcct tctcgacaac gcccttccgg ttgcctcgac ggggcggaca gatgtcgact
     1681 ccgacgccgt agtacttcgc gaccgcggcg aaagacgcgg tgacctgccc gctggagggg
     1741 taacagacag tggccatccg gtcgaagcgc caccgcctcg cggtcccgcc cagcttgcgg
     1801 accacctgat cgagggcctg gaccaggtgc gggaagtcct cggactccgc cagcaccgcc
     1861 cgccaccggc ccgaatgcgc gagcgccccg accagcaggt gagcgtgctc gcccactccc
     1921 cacgactcgg gcgcgtccgg aagctccagc cagtcgaact ggatctcctc gcccggcgga
     1981 tgtgcgatca ccgcgacgtt ccggcccgtc gcggcatgac atggttcgca gtgcgggcgg
     2041 acctggtagc ggcgaagagc gcgggtgaac gttgagtagc cgccttcata gcccaagtcc
     2101 ctgacctcgt cgaacagggt cgaggcccac agatgtggat cgtccgcgag ccgctgccgg
     2161 cagtactgca ggaacggcac gaaggcatcc gggctctgac ggcgctggcc agggacctgg
     2221 tcgccattca gataggcacg gatcgtcttg cggtcacgac ccagatgccg cgcgatcgcc
     2281 gagatcgtcc aaccctgacg acgcagagca tgagcatcca cgtcttcctc ccgcgtgagc
     2341 atccaggccc ccgaacaggc cgaacttgcg cacgcaggct ctccacgaca caccgatacc
     2401 agttcgacac gccgggcagg accacacgaa agacggggag atcaactgag caggtttggc
     2461 cgcagaggga gcagagccag gggagttagc cgcgggtcag catgaccacg gaaataggca
     2521 ccgccaccat cccgcagatc gccaggaacc cgcctacgaa tcgcacgaaa ccctcagaca
     2581 cagcacgggc ttccgcctgc tgccgggaag cccgctccag gccgttcacg atgagggaac
     2641 gaatccctgc agcccctcgc ttcgtggcaa aggctccccc cacgaagatg accgccagcc
     2701 cccagatcaa caggaacaca gcacccgcgg cggggccgct ctgaccggcg agaagcagca
     2761 tgcccgaatc cttcacggcc aggaccacac cggtcaacag ctgcgagcca cagagggcgg
     2821 ggaacaacgg cgagcacgcc tgaggagagc ctgagcgcag ggtggggaaa ttcaagtatc
     2881 gccatcaacg accgccagaa ccgcgccgac gccttccaca tgcgccgcgg cgaccagctc
     2941 gcccagctcc tcggcctcgc cgcccgcccc gacgacccgc acctgcccgt cgtcgcccag
     3001 gccgtcctca ccgagctcga cgcgcccgtc cgccagctca ccgagtacgc caccctcacc
     3061 ggccagcccg aagccgtcgc cctcctccac ctcgccacca cgctcaccac cgactccggc
     3121 gacggagacg acatcaccgt cggcctccag tggatcgccc gtcgtcttga gaccgtccgc
     3181 ccccacggcg agatgacccc cgcggcccgc cgcgccctcg ccgaccgcgc cgggatcgac
     3241 cggcacggct tcggcaaccc ggcctcccac gccctcaccg aagccctcct ccagcacctg
     3301 cccaccccca ccgccggcat caaccgcgcg gactacgccg ccaccatccc caccatcgga
     3361 gccgcacgat gaacaaccgc gcctggaccg cctcccgggt ggtcgtctcc gtcgccgcgc
     3421 tcatcaccgc cggctggtcc ctctacgccg tcagccgcca ctacggcgcc cccatcctca
     3481 tcgccggcgc ctccgtcgcc gtcttcgacg gcatcgccta cggctgccag tacctcgcca
     3541 ccgtcgcctc caccgccggc cgctccggct tcggcgcccg cctcgccgcc ctcttcatgg
     3601 tcggcgtctc cgtcgccctc aacatcaagc acgcccagct catcgccggc ggccccaccg
     3661 ccgcactcct cttcgccgtc cccagcatcg gcctcctcgc catcgccgaa ctcgactggg
     3721 ccggcggccg cgccgacgcc cgcaccgccc gcggtgagca gccctaccgc ctgcccgcat
     3781 acggcggctg ggcctggctc ctcgcccccc gcaccgccgc ccagtccgtc cgcaccgccg
     3841 cactcgccca catccagcac acccacacga acgaccagcc cctcctgtcc ggacagtccg
     3901 gaccgagtcc ggacaccgcc ctcactaaaa ccggcaccga cgccgtccgc gagtacttcg
     3961 ccatggtcaa cccgatcgac gcgatccacg tcgcgcacaa ctcccagccc gccctctcct
     4021 cggccgaact cgcctccctc ctcgtcagct acggcgtccc cgtcgaccag gtccaggtcg
     4081 acatcgtcct cggccgccgc ggccccgccg gcaacgtcga gcggagcggc gccctgccgg
     4141 cccctggccc ccagccggaa ctcgtcgccg cccagtccgg accgtccgga ctcgccccgg
     4201 acccgctccg cgtcgccctt gctcagctcc aggaccgctt cgccgccatg gaccccggcg
     4261 aggtcatccg gatcatcgac aaactgcagc ccgccctcag ctcccagcgc ctcgccgacc
     4321 tcctggccga ctacggcctg aacgtcaccc ggcctgcagt cgacctcgcc ctccgccgac
     4381 cccaggccga acttctcgcc gtgctgtccg gacagtccgg atccggtcct gccgcagcca
     4441 ccgccaccac cgccgtcgag gccctgatcg agtacggcgt ccgggacgtc gacctcgcca
     4501 tccccgccgt ctgcgcccac ctcgggccgg ccgtccgcga ggacaccgtc cgccggctct
     4561 tcgaccgcaa ggtcaaaccg atccgagagg ccgagaccgc acagaccacg gaggccgccg
     4621 aagctgacag catcggcaag ggcggcggct acaactagcc gtccccacac cctcctcgcc
     4681 cgacccaccg gcggccgccc ccacaccgcg gccgccccca cccaggaagg acctcgccat
     4741 gaggatccgc accggacacg ccagccgcga aggcacgcgc gaggacaacg ccgacgccgc
     4801 caccgttcac cagctgtcga ccggcgccat cggcgcggcc gtcatcgacg gcattggcca
     4861 cggtccccgc acctccgaca ctgccccgct cctcgccgcc gtggccgccc gcaccaccgc
     4921 ccaccgcggc cccctcgccg gcctcctcac cgccggcctc ctcatctccg accccggcta
     4981 cgacgacaac gaggccaacg ccgtcggcgt cgccgccgcc ctcgagcccc tcgacgcgct
     5041 cttccgcatc gcctgggtcg gcgactgccg cgcctacggc tggagccacg aggccggcct
     5101 gcgcaactac accaccgacc acaccgtcgg cgagcagctg cgccgcaacg gcgccccgtg
     5161 ggacctggct gcggatcacg acaactggat tcggacctcc ctcggcgacg cgacggtcgc
     5221 cagcgtgtac gaggtcctga tcccggacgg gctcgtcatc ctcacctccg acggcgtcca
     5281 cgactacgtc gagcacggac acctcgagga cctggtccgc gagcacgcga ccgacccgca
     5341 ggccctcgcc gacgtcctcg tctccgccgg cgagtggggc accggcgggt accgggacga
     5401 cgccaccgct gtcgtccttc ggcggggatg atggcctcat ggaagccctg atcgcgttcc
     5461 tccaggcccg cctcgacgag gacgccgcag ccgcccacgc tgccactccc ggcccctggt
     5521 ggtaccaccc tggcaagcag tggctggagg gcgagtcgtt cgagagctac gacctgacca
     5581 aagggctgga gttcgtcggc tacggcggcc cccacccgtt caccggcgcc gtggccggca
     5641 cagggcccgc cgaccacccc cagagcatgg ccgacgcagc acacatcgcc cggcacgacc
     5701 ccgcgcgagc gcttcgcggc gcggaggcgc tccgcagcct gctgcacgcc tacgagcacc
     5761 ccgagaccag ccccgagctg ccggactccg tgaacacgct gaccacggcc atccagcgac
     5821 aggtgcttga gaaggccctc cgcctcctgg ccatcgcgta caacgaccac cccgactacc
     5881 ggcccgagtg ggcccccacc acctgaggag agcacgatga gcgagcgcgt gaacgtgaag
     5941 gtcctgctgc tgatcggccg cgaagccgag atcgtcgccg acgcggacga cgcgaccacc
     6001 ccggagcggt accccgcggt cgagatcgcc gccgcggtga gccttcccga gggccagctg
     6061 ccggggaccc ggctgacggc ccgggtcggg gccggccacc ggctcttcga ctggcgcctg
     6121 gcgagcgacc agcggccgac ggccggcggc cgcacgccca cgccgatcgt cgagctcacc
     6181 gcgcccgcga gcggagcgct gggggagcgg atcacggacc acctcggtac ggcccaccgg
     6241 ctgctcggcg aaagcccggc gtaggcagcg acacgacgac ggccccaaca cgcttcagag
     6301 ttggggccgt ctctcagacc gtaagtgttg caattcgggg cagttgggtg catgctggag
     6361 tcacaaggaa ccgggccgcg aacccgggac caccacccac cacagaaagg cggacctcat
     6421 gtccgaccag cgcgacgaga tcctggcgca catcgcccac gacctctccc tcacctactc
     6481 gaagctggcc atggcctgcg gcaacctccc cgtcccggtc gccatcccca ccgggtcggt
     6541 cagcaacgtc gaggctatcc ctgccgtgcg ccgcgtcgcg gagctcgccg aggacgtcac
     6601 gatgccggtc gaccagcagg cgcagctctt cgccagctgc tgcttctggc tcggggccat
     6661 ggacatctac gggctgctct tcgccagctt ccacgacgtc cgggcccact cggcgctcgc
     6721 caacctgatc atggcgaacg agagcctgga ggacctcctc gcctggcttc gggcccacac
     6781 cgagatgaag taacccccac ggcccccggc agccagccgg gggccttccc gtgcccccag
     6841 aatgtagacg gaccggcagg gccaggccga agcccagacg cccgctcgcg cggacgctcg
     6901 cgaaaccctg ccggtcccac ccagccccag agaggccagg ccaccatggt aaacacgcca
     6961 cccgccagcg agacgctcag cgagatcgcc gcccgccacg gccgctccga gaagacgatc
     7021 cgcaacacct gggcccgaca ccccgactgg ccggccgcgg tcggcaagcg cggcagggcg
     7081 tacgtgtacg accccgccgc cgtcgaccag gtcgtcgccg accacttcgc ccgcccggcc
     7141 gccgacctcg agccccgccg cctctacacc actgccgaga tcgccaccgc caccggcctc
     7201 aaggccgtca cgatccgcgc cgaagtctcc aagggccgat ggccggccgc cgacgacacc
     7261 gccggccgag tacaccgctg gtacggctcc accgtcctca aggccctcca ggaccgacgc
     7321 ggctaccgct ccaccgactg agcggcgaaa cctgtccagc ccgcccgccc tcgacagcga
     7381 gcgccggaac tcgacatcgc cgccgagtag ccgccatcga cgcgcagccg gccgatccct
     7441 gggggatgtc cggcgtgccg tgaccgccgt cgacctggcg accgacggcc tccgcagcgg
     7501 acgtcgaccg cccggcgaag gggggcgcag ctcggccccg accgggccgt ctcggggcgc
     7561 gcctgggtgg acgcgcgcgg ggccgggggt gggggagcag ctcgccgggg gcgcgggccg
     7621 gtgggccgct gcgggagggg cgccctccgg gccctggcgg gccctgcggg tgatccccgg
     7681 gcgcccttcg ggcgcgttca ccggggatca gtccgcgcaa gcgcggaccg ctctggcctg
     7741 cgccttcggc gcgcaccggc cagagttccg gcccctgcgc cttcggcgcg caccggggcc
     7801 tccacccctc ccttccggcc caccggcccg cgcccccggc ggcgaactcg tcgtgaaatg
     7861 aacggagttg accaatcccg agtgttgcaa aacggggcag ttaagaggag aatggaaacc
     7921 gagggcagca aggggccgca aaccctaagc cctcaccagc cagcaacact caacaggaag
     7981 aagacaccat gtccgaccag tacgacgagg acatccagaa ggtcggggcc gccctgatcg
     8041 ccacctacga catcctcgtc cgggtctgcc tccgcctccc gatccccgtc accctcccga
     8101 ccggcccgct cctcgactcc gccgagctga tcccggccgt cgcccgcgtg gtcgacctca
     8161 tggaggagat gcccgcatcg acggacctga agctgtccgt cttcaccgcc agtctcaact
     8221 ggctcgcggc cgggaagctg ttcagccgct acctggacca ccccgaggac accacggcca
     8281 agccggagat cgaactgatc ctctgcggag ccgctgaagc cctcgccaac gcggcggcac
     8341 tcctgcacac ggaggactga ccgaacggcc ccccggcacc cagccggggg gccacccgcg
     8401 cgccgaaagg acggccctac gggccgggcc gcccctatgt ggcctgcggc cacgggcgac
     8461 cgaaatggaa aggcggcccc ctatgtgccc ttcgggcacg ggccacctgc ccgccctgcc
     8521 gggcgggggc gctccgcgcc cggccccctc aaggcgcttc gcgccggggc cgcccctgcg
     8581 gggccaagga gcgcgctccg cgcgcacccg ggacgggcct acggcccgcc ccggatcccc
     8641 tcccctcgga ctcgccgggc cgcagcgcgc agcagtctcc aggggcacgt ggagggctct
     8701 gcgctctcgc tacgatgaaa gtgttggcct ccctggggag gctggctggt gaccggtggg
     8761 gttttgcgag cgcctgctct gccaggcgtc tgggcttcgg cctggcccca ccggtcttgc
     8821 tgtctggagt gcgagcgaag cggcgctccg cagcgtccag gcggcatcac gaccacggcg
     8881 tgtctgcagc cgagtcggct acgccagacg caggcgccac ccgggctccg gaccgtcgaa
     8941 aacggggacg agcgtggccg agtagctctc caccgccggc cgggcggcct cctcccaagc
     9001 gcccagccac ctgcgcagca ccgcgaggga agcagagccg ggggcatcgg cgaagatcgt
     9061 gccgttctcc tcgatcacgg cggccgacgt cggcgtgctg tgcccgatgg cccaccggcc
     9121 gccgcgcact gcgcccacgg tcagttgcgg gtccgcctga gccgcgacga acgcctggaa
     9181 tgacgcccac ggcagggcac cgcccgcgta cgtccctgtg tgcgcccccg ggtcctgcag
     9241 ccgctccagc gtggcccggg ccccactgcg caaccggtcg tcccggtccc gccagccgat
     9301 cgagatccac gccggcgcgg gcacccgggt ctcccagtcg acccaccggc ccggcgcgtc
     9361 caggtcctgc ttcggcgagg tggtggcgtc gacgtactcg ccgtggaaga cctcctccac
     9421 caccggcttc ccgccgctca cccggacctt caccaccgcg gtcatgtgcg gcagctcggc
     9481 gaccggcaga ggcgtcacga tgaccgcctc gtccgtgctc tgcgcgaccc actcggccgg
     9541 caggagcggg ggagtgcacc acgccaccgt gcggtggaac ggcgcgtgcg cggcacgggc
     9601 cgggtcgtcg gcgaggtagc agcggacgtg gaagtccgcc tgctggtggt ggatgaggtt
     9661 cgcccacgag acgaggtagg ggtcgatgtc caggctcgtg acgctgcccg tgcccccgac
     9721 gagctgcgcc agcagcgcac cggagtaccc ggacccggtg ccgtgctcga tgaccttcat
     9781 cccgggctgc acgtccaggg aggtcagctc gcggtggatg acccgcggag cggagcggtg
     9841 cggggtttcg ccgcgcccgt cgtggtgggt gtagtggcgc tcggggacgg tgtcggcggc
     9901 ctcggcgacg acggtcatag cactccttca ggtgacacag ggtgggcact tgcttgcgat
     9961 aactgctccg ggcgggtgat ggacacggcc gcccggaagg tcagatcttg agggccggca
    10021 ggtggtgcca gccccccgcc gtgtactcgc cgacgggtcc gtggccaggg agctccaccc
    10081 aggcgtggta ctccaccggc gggggaacga accgggcccc gacgcaccag tcgagccggc
    10141 cgccgaggag agccaccgcg aggacggcgc tgagggacgt ctcgaggcat gcggcccgcc
    10201 cgggccacca gcgagccgca tgcctcacag cttccacgac tgcctccgcc cgagccggcg
    10261 ccaccggccg tcggccgagc cagcgcgcga tgcgcaccgc gcgcgccgtg cgccggaacg
    10321 ggaaccgcag cagtaccagc gccgccgcga acccgaccac ggcggccgcg cgctcgacgg
    10381 tagacccggt acgggaggtc gagtacgcct ccatgctgct catcgcgacc accaccggcg
    10441 ctgtgcgggc tcgggcgcac cgtcgtgggc aaggccgagg cggaccaggg agcccgccac
    10501 ctcgccgaca tccgcagcgg cccgctcccg gccgatgctg taccgcgcgg cgtaccgttc
    10561 cactgcctgc tcacggcccg gcccggccag gagcaggagc acggcggccg agctggtggg
    10621 ggagaggtac tgccatcggc cggtgtgctc gtccaggatc gcgccgccct catccgtcag
    10681 caccgggtgc gcgtgctcac acagctgcca cacggtcacc ggcctcctcc caccagccga
    10741 tcgccgcggc gtcgagctgt cgcagccaca cctcggccgc gatcgccgag tggatcgcgc
    10801 cctgtggcgc cggctgcccg gcgaccgctc gcgcgagcgc ctcggccacg ggctgctcgg
    10861 tcagcaggcc catcgtggcg agccgcgacg acggcccgag caactcccgc atccggacgg
    10921 cggtcgcctg gatccccgcg tacgcgaccc cgttgaagcc tcccttcgtc cgccgctcca
    10981 ggacgaacga cggcacaggc cccgccttga acgcggcccc gagcagcggc ttgaactcgt
    11041 agggcacccc gcgctgctga gcggggaccg ccaggcaggc cctcatcacc tcggagtcca
    11101 ggtacggggc cgcgatgtcg acgccgtgac catgcctggc gagcgcccgc agcccagcag
    11161 tgtccgcgcc gacacgggcg agatcctggc gctcggtcca caccgccagc tggtccggag
    11221 cgtcatcaac ctcggccgca gcgtcgtcga ggagcgatgc gagcatcagc cgcgccccgc
    11281 gggtcatcca gtctgcggtg gccagcaacg gtgtccacgc caccggccgc tgcgcctggg
    11341 gaacccacgg ccgcgggtcg gcgcggagct cgcgggcgac ggcaagccac cccccgggca
    11401 ggtccaagcg gctggccggc agcgcgcggc ggaacgtctc gatcccggac gtcctgcgca
    11461 ggcgcgcgtg cccctgggcg tgagaccacg cgcgtcggcc ctttcgctgc cggagcaagt
    11521 cggcgatgta ttcggcgccc gccgacagta ctccgtcccc gccgacgcct gtcagatggg
    11581 cgccgcccgg cccgttcatc tccacgaccg cgtccagcac cgcccgcttg atgggcgcgg
    11641 tcacgacgta cgcggacggg gcgtccgtca ccggcaggtg cgtcaagtca tcgaggcccg
    11701 cgtagtacac cgtgcccgcg ttcccgggcg cgatgcggtg ccggatgctg tcgaccgtca
    11761 tggcggtgcg ggccgcgtac gtgaggtcgt cgtcacgcag ccgctcgtcc gcgaaggtga
    11821 cagccgcgac cgggcctcgc tcggccgcca ggcatgcgag cgtcgtcgag tccagaccgg
    11881 cgagatccgc actcaccgac cggccgtcgg cgcgcagggc cacagccgcg cgcagcgctg
    11941 cctgcacccg tgccgctccc gtacgcaggt ccaccggctc gtatgccacc ggctcgtatc
    12001 gcacgacccg tgccccggag ggcgtcagct ccagcagcga tccggtgggc acccgctgta
    12061 ccccgcggaa caacgagcgc cggccggtca cgtcgggctg cccgaacgcc agatgcgcgg
    12121 cgagcgcggt cgtatcgact ggtgctccgt ccagcgaagc gagagggatt gccgcggtcg
    12181 accaccaggt gccgcccgtc tccggccgga agtacaccgg atgctgcccg gacaggtccc
    12241 cgatgatcac ggtcgactcc ccgtgccggg cgaccaccgt gtacgagccg ggccagcggg
    12301 tcagctctgc ccaccggccg gccacgacat gccgcaggcc ggccaggagg tgctcctcgt
    12361 cggccgcgca ttcaccgacg accgccaccg ctgcagcgtc gacggatgtg gacaggactc
    12421 ggtcatgcgg ccattcggcc gtccacacgt gctgaaaccc cgtgaccggc cggcccgccg
    12481 ccggcctctg gacgggggag tggccaccgg accaccccgc gctccacctc atctgatgcc
    12541 tcccgaacgt ctgaactgca tgtagaagag cgaagacgcc ggtcctgccg tcctgccggg
    12601 acggggcagg acggcaggac cggcgcctcc agaggcgggg cagccgacga cagctgcccg
    12661 ccccgccgcg cggtgagatc agtgcttgta ctgggtgtcg tccgcggtgt cgaaggactg
    12721 cgtgccgagg gtgacctcgg cgacggtgcc cacggcgatg accacggggg cctcgtaggc
    12781 gggggtgacg atctcgacct cggtgatctg ctgggccatg acggcttccc ttcgtcagtg
    12841 cccggcacct ctgcggcgcc ggggcgatga cgattagtga actcgtgtct gcggagcgcc
    12901 aacagctgcc acaatgtccc ccagctgtag tccagttgta gcccagctcg ggacaggatc
    12961 gtcgagacga tgaccactgg ggaccgcatc cgcacagcgc gcgagaagcg cggctggagc
    13021 cagatccgcc tcgcaaagga gttatccacc gcacgctggg gcgtcgagga ctacctcggc
    13081 cggcagcagg tctaccgatg ggagaaaggc ggccgcgccc ccaaggactg gcgcccgttc
    13141 atcgagcaag tcctcgacat cagcctggag atcaacccga ccgccaccat tcagacaccc
    13201 gatctcgata cggtggcctc agtcatgcag ctgggaggca ctgacgtgga ccgacggacc
    13261 ctactcgtag ccacggccgc cgccagcctg gccgcgctcg acctcaccga cgccgaagcc
    13321 gtcacccgcc gcgtcagcaa gcccggcccg gtcgcagtgg gcgccggcga tgtctccgcg
    13381 gtacggatca tgaccaccac cttgggcgac gcggcctccg aactcggtgg cggacacgcc
    13441 cgccacctcg ccgtccgcta cctcaccgtc gacgtcaaac gcctcctcga cggccgctac
    13501 accgacaaga ccggccgcga cctgttcgcc gccgcctccg agctcgtcca cctcatcggc
    13561 tggatggccc gcgacgaagg cgactacggc ctcagccagc gctacaacgt ccacgcctac
    13621 aaactcgccg ccgaagccgg cgagaacgaa ctcgccgcca ccgccctgcg cgccctcgcc
    13681 gaccaagcca tcgacctcgg ccacatcccc accgccgtac gcctcgccga agcctgcgag
    13741 caacgaggcc gcaagctcga caacccgaag gcgctggcct actaccgcaa caccctcgcc
    13801 cgcgccctgg ccgccgaccg cgacgacacc gccgccgccc gcctgctcac ctccgcgcag
    13861 accgccatcg aacgcgcccc cgcccggccc ggccaatcct gggccagcca ctacagccac
    13921 ggccgatggg cccacgagtc cggcatgatc cacgcccgca tgggcgactg gtccgccgca
    13981 gaggaacacc tccgcctcgc cctcgacatc cacggcctcg accgaaaacg cacccgcgcg
    14041 atcgtcctcg ccgacctcgg gcacgtgcag gtgcgccgcg gcaacaccca ggaagccctc
    14101 accacctggg acgagttcct cgacatcgcc gacggcatcc agtccgtccg catcaccgac
    14161 ggcctcacca acatcgctgc ccgcctctcc tccctacctc cctccggaag ccagcaggag
    14221 ctgctcgaac gcgtcagcgc ccgcctgtaa cgcatcgggc cgcgcgagta cgaggcggct
    14281 cttcacattg atccgtccgc accccatgag aatctccaaa ggaagtaacc cagttgtacg
    14341 gcggcaccgg tcgtgcctac cgtgatgccc acgacgtaag cacctcccgg tgcgcaggcc
    14401 gcggttactt ctcttggaat gaaaatgtgc cgctgccgac cttgatctcg ggaggcgtga
    14461 gcttcggggt gcccggtgcg caggccgggg ttacttccca ctgctaatgg ggtggtcgcg
    14521 ggttcgaatc ccgccgaggg ccttggccct cgtagctcag cggccagagc accttgtacc
    14581 ccagccgacc ttgatctcgg gcaccccgcg ctcatcctcc cctccctgca gaggggttgc
    14641 accatgtccc gcttcaacac ccgcgccgcc cgcccccgcg ccacctcgcc cgtgaccacc
    14701 accggggagc acacggccac ctacgaggcc gccaccgggt acctccgcga cagtaagagc
    14761 gagctctacc tcctcgccgt ccacaaccgc gtcgcgaccg acaccttcta cgagaccggc
    14821 accacccgcg acgaccgcta ccgccagctc gtccgcgaac tcgctgtcct cgacccggcc
    14881 tggaccgcca gcttcctcgc ctggctccgc acccacggca acatgcgcac cgccgcgatc
    14941 gtcggcgccg ccgagttcgt tcacgcccgc ctccacgcct ccaagaccgc cgccctccgc
    15001 ccgggcccca tcgccgtgga catcgcgccg cactccgacc gcgccgtcat cgcctcggtc
    15061 ctccagcgcc ccgacgagcc cggcgaactg ctcggctact ggaccaccca ctacggccga
    15121 cgcctgcccc agccgctcaa gcgcggcatc gccgacgcca cccagcgcct ctacaccgag
    15181 cgcgccctcc tcaagtacga caccgactcc cacggctacc gcttcggcga cgtcctcgag
    15241 ctcgttcacg ccgcgcccgc cgcgaacagg ccctggcagg gcgacctctt caagcacgcc
    15301 atcgaccgcc gccacaaccg agctgaggac gtccccgccc agctcgccac catccgcgcg
    15361 cgcaacgacc tccaccgcgt ccccgtccag gagcgccgcg ccctcctcgc cggcggcgct
    15421 gaccggctcg cggccgcggg catgacctgg gagtcgctcg ccggctggct ccagggcccc
    15481 ctcgacgccg cagcctggga ggccgtcatc ccgagcatgg gcctcatggc cctcgcccgg
    15541 aacctgcgca acttcgacga ggctggcgtc tccgacgccg tcgcccaagc cgtcgcggcg
    15601 cggctcgccg atcccgacga ggtccgccgc tcccgcatgt tccccttccg ggtctgggcc
    15661 gcctacaagg ccgcccccaa cctgcgctgg gcccaccccc tcgagcaggc cctcaaccac
    15721 tccctcgcga acgtccccgc tctcagcggg cacaccctga tcctcgtcga ccgctcgccc
    15781 agcatgttcc ccggcttcta ctactccacg gcgaacacct ccgacatctc actcgccgag
    15841 caggccgcca tcttcggtgc cgcgctcgcg ctgcgcgccg agaaccccac cctggtggag
    15901 ttcggcggca cctcccggga gatcaccccg aagaagggcg gcagcgccct gcccctggtc
    15961 gaacagttcg gcagcataga cggcaccgac atcccctccg ccgtgaagaa gcacttctcc
    16021 ggccacgacc gcgttatcgt cgtcaccgac gagcagaccc gccctggctg gctcccgtcc
    16081 aacatgatca gctaccaggg catgccggag acccggatcg acgacctcat cccggccagc
    16141 gtccccgtgt acatgtggaa catggccggc taccggcccg gagccacgcc cgccggtggc
    16201 cgcaaccggc acaccctcgg aggtctcagc gacgccgcct tcagccttat cccgctcctc
    16261 gacgccggcc gcgacgcccg ctggccctgg gaacaggccg acgcgtagcc gctggtggag
    16321 cgggaggccc attccgtgag tacgccgtat ggatgaacag ggctaggcgg gaagcgcgtt
    16381 ggcggccacc atgacggatg tcccactcgt catgggcacc gcggacgacc gtctgtcgct
    16441 gggaaaccgc gacacccgcc aggggcggcg taagccggtc gacgcagaga ggacctcgac
    16501 ccccagtcga ggtcctcgcc cgttttccag gccaccggct acttgccgcg cacccacttc
    16561 catctcgccg accaccagcc cacgcggtac agctgccacc accgaggcgc gtaccacaga
    16621 tcctcccggc accggtccgt gaacgccctg tgtgcttcca gcgccttctc cagcgcagcg
    16681 ccgaaggcgt gttcatcgaa ggaaggcccc gtgtccatca gattggacgt cgccgacatg
    16741 aggtcgtcgg ccgcggcgag gggcccgggg ttggccacca gccggacctc caggtacgcg
    16801 gacagcaact ctgtctgccg ctcctgcgtc atggcgagca gagtgcgcat gcgcccctgc
    16861 cccatgaacg tggaggcgaa cttcttctcc atccgcaagg cctgtgcgaa cgatgccgcg
    16921 tcggcatgcg catgcgagta ccgcgcgtac acaccccgcc gctcttcacg cccaccgaga
    16981 cgtggcgcca gacgggcggg ggacttcttc aggagcgcac tggctatggc gcgagtgccg
    17041 gccgaagccg cagcgctggt gggatcaatc atgaccagat ctaaccagtg ccgcgaagag
    17101 tcacgggccc gaacggacga gcgtcaacca ggcagactgg agacataccc cgccgccccg
    17161 gccccggacc cctacgcacc gaggagcccg ctgtgcacac cgcccccgac gtcagcgact
    17221 acgagtggcc cacctgcacc aacccccgct gcggccgcgc cctgtggccc gaggaagcgc
    17281 accgtcacgt ctgccgcccc tgcgagcaga ccgtgaaccg gctccttggt gaactccccg
    17341 cgctcttcgt gcgcctgtcc accacctcag ccctcctgcg ccgcgtcggc aaccgcagcg
    17401 ccgccgccag cggccgcgac accccgccga tccctggccg cctcgaggtt ctcgacctca
    17461 ccggccccgg aggcgccgct gcccggctcc aggccatcga agactcgtgg cgagccgccc
    17521 tcggccggcg catcggcacc tgggctggct ccccggccca agccctcccc gtccacgtca
    17581 ccttcctccg catcaacctg gagtgggcct gcgagcagta cgccgccgtc gaccaggacc
    17641 tcgaggtcat ccgccgactc caccgcgact gcaccaccgc cgtctccggg accccgcgcc
    17701 ccgcccacgt cgggatcggc acctgtcccg cccgcgacgc cgatggcgct ctgtgcggcg
    17761 aagatctctc cgcgaccact gcccaccacc gcatccactg cccccgctgc ggcgcccgct
    17821 gggacggcct cgccgactgg cgcaccctcc gtcgcgctca ggaggcagca gcagcttcca
    17881 ccgcgctgat ggacgaggag ccgaccgagt tcgccagcca gactctggag aaggccaccg
    17941 cctacacagc ggacgatgac gacgttgaga ctggcgagct ccccgtctac gcgtacagcg
    18001 gaggagcgtg ggtgcagcga tgacccagca gacaaggacg cccaccggcc cgacgcccgc
    18061 ccccgtgcag ctgcgcctgg acgtcggcga gttcctcctc gcgcgtctct tggaggcccg
    18121 ggagctcgcc caagcggcca gccccggtac gtggaggtcc aacgaggagc acgacgaggt
    18181 cctcgccgtc gacgacgtca ccgtcgcgga cggcttcgcg ctcagcgggc gtcagctacg
    18241 cgccaccgtc gaccacatcg cgcaccacca tcccgtcagg gttctcgccg acatcgccgc
    18301 caaggaggag ctcgtccggg agtacctcct cgcagcccgc gaccccgcct gccgaacgga
    18361 tccggcgttc catctccagg tgcacatcct gcgcatggtg gtcaccgccc tcgcccgtgc
    18421 ctacgacgac cacccggact accggtccgg gtggtgaccc gccttcagtg ggccgggaga
    18481 gctggcctgg agacgatcta gcgacccgcg gccccctgga tacgctcctg cccgtgacta
    18541 catgcaggtc tccactgcta cggagaccga agagcaggcc atcgagctgg ccagcgacgc
    18601 agtgaggaac cgactcgccg ttggcgcgca gatcaccaag gtcaagtccg tcttctggca
    18661 ccacggcgag tacggcaccg gcgaggagcg gcagattcgt ctcaagacga cggcggaccg
    18721 gtacccggaa ctggaggcgt acctcctgga agcgtacccg tgggacaacc ccgaggtctg
    18781 cgcggtcccg atcgtggcca gcgctgagcg gtggaagcag cggatcgaca ccgtggtcga
    18841 ggagcagcgc taggactggc ggtcgctcgc catggcgcat atcggccacg tggcttcccc
    18901 tgacatgcag tgatctgaat ttgtacgatc gctgcatgat tcgtgcagtg gtgtttgacg
    18961 tcggtgagtg cctggtggac gagaccaggg agtacggcac gtgggccgac tggctcgggg
    19021 tgccacggca caccttcgcg gccatgttcg gcgccgtgat cgcccaaggg cgcgactacc
    19081 gggacgtctt ccaggagttc cagccgggct tcgacctcta cgagcagcgc gaggcccgcg
    19141 ccgccgccgg tcagcccgag cacttcggcg aggaagacct ctacccggac gtccggcccg
    19201 cgctcgcgca gctccgcgcc gacggcctgt ggctcggcat cgccggcaac cagaccaccc
    19261 gggcggggaa gatccttcgc gagctgttca ccgaggacgt cgacttcatc ggcacctccg
    19321 acgactgggg cgcgtccaag cccgacgtcg agttcttccg gcgggtcgcc gaggtcgtgc
    19381 ccttcgagaa ctcggagatc ctttatgtcg gcgaccgagt cgacaacgac cttcgcccgg
    19441 ccgtgaaggc cgggatggag tcggccctcg tccgccgcgg cccctgggcg accatccagt
    19501 ggaacaccga ggaagccgaa aagctcccga ccttccgggt cgagagcctt gcggaactgt
    19561 ccggcaacat catccagttc aacggccgag ggcgctgacg gtcgtttccc agccgtacag
    19621 ccggtcatcg aggtcgcgga cacagcgctc gtgctgccac ggtgcgagcg cgcggcgcac
    19681 gtcgcggacg cggtccatgc ccgtgctgta ccaggtgcgg cggagctgct cgagggcggc
    19741 gacggcgtac tcgcacgcct tctccgggtt gcggtcggcg gcctcgacag cagccaggtc
    19801 gccgaagatc accgtgcgct gcttgtcctc gctcggctcc agaccgtcaa ggaccccgag
    19861 cagcgtttcg cgtgcctgag gcaggtggcc ggctgtgagc tgcgtgtgcc ccttgaaagc
    19921 ggcgaggcgg accgggctga accagtccat ccactccggc gaagggatat cggggccggc
    19981 ggtgaggacc tcctcggcgt gcccgaggag ggagagcgcc gtctgggtgt ggccgcatcg
    20041 ggtctcgcat tcggcctcga cggcgtcgag ccacgcgagg aaggctgcgg aagcttcccc
    20101 gcgccgggcg tacgtccggg cggctgtcat ccgctccacc gcggcctgcc ggtcgccggc
    20161 ccacccgggg atgaaggcgg agtgcgcgag gatcgcggcg ccgaggagct gatcgtcggc
    20221 ctggctggcg gcctggaggg cacgggtcca tgtctccttg gccgtgtccg gctcctggct
    20281 gtcgaagaac tggattcgcc ctgcgaggag gaaggactcc gcgagcgcgg ccgcgaccgt
    20341 ccgccgggcg atgccggctg tttcggggag cagggcgcag ccgagggcag tgtgggcggc
    20401 gatcgccggg tggagggtcg cgggggcgac ggtccagtag aggcggcggt gccgccgggt
    20461 gacctcagcg aagtcctcac cggcagtggc cggctggagg gtaacgccgg gcacgggcac
    20521 ggtaaccatg cccctggtcc gcggcagctc ccgcggctgg ccgtcccgct gtgcgcggat
    20581 gccgtccggc ggagtgaagc cgaggtcttc catgttctgg ccgaggaggc tcgtcagcgc
    20641 gcgccggacc gcgtcccggg gccatggcgg gttcgccgat tcccagcgcc ggacctgccg
    20701 gacggccacg ccgacggcgt cggcgagggc ttcctgggtg ccgtagcctg ccgcgatccg
    20761 ggccgcgcga agcagcacgt tgccgtcgtt ctccacgtct ctcacctccg tatgcgatgt
    20821 gcagcaccag tgtggagaag agtcctgtgg aacgccagaa atccccccaa cggatgagag
    20881 aaagtccggt atttggtcag gagagacctc tcaaagacct cgtaggtgtc ggacctgagg
    20941 accaaggttg tgccatcgac ccaacagatg agggaacgtg atggctgacc cggagctact
    21001 gaccacgagt aagaccgaaa gtgaaccgaa gaccgtcggc gcggagtggg acgccatcca
    21061 ggtcccgcgc agcgttggcc tcgttgccct gaacattctc ggcgcgcgca gcggcgccgt
    21121 catcgaggac gagacggccc tctactggct gctccccgcc ggctcgacgg aaggatggag
    21181 cactcgcggt acgaaggcgc tccccacggg aacgacgctg gacgtgccgg tcgcccgctg
    21241 caccaccggg cccggaccgc actggcggat ctgccccggc gaggaccggc tcctcacctc
    21301 cgtggacgcc cttcgggcgg ctgtggtcga cgcatccgga ctggccggag ggcagccctc
    21361 cccgagtggg accgccgcgc gatgacgggc ttcccccacg gaccggttga ggcagcgccc
    21421 ggcgtgctcg tccactcgcg cagcgaccgc gaggccggcg ccgagacctg gttgatcctg
    21481 gccgcgcacg acaaacgtca ggcccagcgg gagtgggcgg agtacggtgt cgcgcttctg
    21541 cgctgcggca agacgttcac tgccatccgt gtccccgccg agatcgttca cgccgtggcc
    21601 ggtacctcgg accgggacga ggtggcgtcc tacctggcga cggccctcga ccgcgggccc
    21661 tgtttcttcg acggcaacag ccagtcgtac tacgccctcg ccccgcgcag tgccgcagga
    21721 cgttggagcg tgcccggcac ggaggccctg ggcggcgact tcttcctcgg tgtcccggcg
    21781 accacgatca cggcgcccga cccgcggtgc gcggcctggt gggtcgtgcc gatggaaggg
    21841 ccggccgcgc tgtgcgacgt gggcatcgtg cggtggctgg tagagcgggg caggatgcgg
    21901 ctcgcggagg tccgggcgtt ggaggcgagc gaggatgctt gacgcccccg cccgccggcc
    21961 ggagttcttc ctcactgcag acgagccgtc ccagtcccgc acgctgcggt gcgacccgat
    22021 gtcggtcgcc gtcgcgcggc gcctggtcgt cgccgtcctc ggccgatggg agctttcgga
    22081 ggacctggcg gagagggccg agctcgtcgt ctccgagctg gccaccaacg cgatcgtgca
    22141 cgcccgtacg tgcggcgccc cgatccgggt cgccatcacg cgcggcgagg acgaccacat
    22201 ccaggtcgcc gtgaccgatc tggaccggcg tccgctgggc ccagcgcgga cggacccgta
    22261 cgccgagggc ggccgcggcc tggacctcgt cgccgcgctc tccgtgcgct ggggctgcga
    22321 gcgtcggcgc tggggtaagc gcgtgtgggc cgagctcgct tagccgaact cacctagatg
    22381 tcctggccgc gtcgacggcg gtggccggcc aggaaagggg ccctccccgc gagcccggag
    22441 ggggtggtgc gtgaccgacg ccgaccggca cgcaccccgg ccactggccc gtccacgacg
    22501 ggccggtggc cggcccgccc cactaatgcc ct
//
