LOCUS       NZ_JABBGE010000002     10399 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. R302 contig2, whole genome shotgun sequence.
ACCESSION   NZ_JABBGE010000002
VERSION     NZ_JABBGE010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. R302
  ORGANISM  Streptomyces sp. R302
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 777377)
  AUTHORS   Dahal,R.H.
  TITLE     Streptomyces sp. R302 sp. nov., isolated from soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 777377)
  AUTHORS   Dahal,R.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) Life Science, Kyonggi University, Kyonggi
            University, Suwon, Gyeonggi-Do 16227, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2020
            Assembly Method                   :: SPAdes v. APR-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012927245.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 03:52:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,357
            CDSs (total)                      :: 7,271
            Genes (coding)                    :: 7,075
            CDSs (with protein)               :: 7,075
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 1, 1, 3 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 84 of 196
            Pseudo Genes (incomplete)         :: 164 of 196
            Pseudo Genes (internal stop)      :: 20 of 196
            Pseudo Genes (multiple problems)  :: 67 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:44:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 698904
            Orig. end                         :: 709303
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBGE010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="3"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    721..736
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(1012..1027)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            1350..2048
                     /locus_tag="HHL19_RS08970"
                     /old_locus_tag="HHL19_08975"
     CDS             1350..2048
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003954866.1"
                     /locus_tag="HHL19_RS08970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_08975"
                     /product="hemolysin III family protein"
                     /protein_id="WP_169087395.1"
                     /transl_table=11
                     /translation="MTAATPEVTPVEPEPTAQTPSLPLKPRLRGWLHAGMFPAVIVAGL
                     VLVALADSPRARIACGVYVLTACLLFGISALYHRGNWGPRGEAVLRRLDHANIFLIIAG
                     TYTPLTLLLLPDSTAKPLMWAVWAAAAAGIAFRVFWVGAPRWLYTPCYIAMGWAAVFFL
                     PDFMRTGGIAVLVLVVVGGLLYSAGGVIYGMKRPNPSPRWFGFHEVFHSLTLAAFIVHY
                     VGISLVAYQS"
     gene            2076..2672
                     /locus_tag="HHL19_RS08975"
                     /old_locus_tag="HHL19_08980"
     CDS             2076..2672
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519079.1"
                     /locus_tag="HHL19_RS08975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_08980"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_240981480.1"
                     /transl_table=11
                     /translation="MASGLRERKKQKTRAAIRRAGRRIAAAHGWEAATIERIAAEAEVS
                     PSTVVRYFPVREDILLTDEDDERLEALLRARPAGEEPLESLRAVVVEAIGAALAADPEE
                     LRVRARLMAGTPAVRARLTETTAETGRRLARALADRTGRAPDDLEVRVFAAAVLGALRE
                     AVLYWAERGLAEDLTALLHRTLDTLKAGPSLPARP"
     gene            complement(2638..3669)
                     /locus_tag="HHL19_RS08980"
                     /old_locus_tag="HHL19_08985"
     CDS             complement(2638..3669)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035843.1"
                     /locus_tag="HHL19_RS08980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_08985"
                     /product="glycosyl hydrolase"
                     /protein_id="WP_169087399.1"
                     /transl_table=11
                     /translation="MSRLRPRSRPRAALLVLLAAVAALVLAPGIVGRLAPGERHTGTAT
                     APEPSPLPGVPSGFFTGSDAEGVRRIAGAEAWLGGGELTVGHTYLPGDRWSNIEGHREL
                     FAPWARWKAGRPGRLFVLNVPMMDRNEAGLSDAEVREGLRHGAGGAFDAHFEALGEGLV
                     EHGLGDAVLVLGWEMNGTTYGHRCGPDPAAWKAYWRQVVGVLREVEGQRFRFDFTPSRG
                     RDAVPWPECYPGDDVVDIIGMDAYDQPEGVSFEEQVSEEYGLAHHVAFAKEHGKPVSYP
                     EWGLFRNGDNPAYVRGMLDWFALHRPVYQTVTDYCPHGVWGCAANPRSAEVVRGALGAT
                     ARP"
     gene            complement(3671..4330)
                     /locus_tag="HHL19_RS08985"
                     /old_locus_tag="HHL19_08990"
     CDS             complement(3671..4330)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239817.1"
                     /locus_tag="HHL19_RS08985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_08990"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_169087401.1"
                     /transl_table=11
                     /translation="MTTLGVRSGVPGQRREDRAARDLRSEDGTVGAGRGLGWLLVVTGA
                     AGILAAWVITIDKFKLLEDPGFQPGCSLNPVVSCGNIMKSEQAAVFGFPNPMLGLVTYG
                     VVLAIGAGLLAGARHRGWFWLGLNGGMLLGVGFCTWLMQQSLYEINALCLWCCLAWTAT
                     ITMFWYVTAHNVRTGVLPAPAAVRGFLGDFAFAPPVLHIGIIGMLILTRWWEFWTS"
     gene            complement(4348..4851)
                     /locus_tag="HHL19_RS08990"
                     /old_locus_tag="HHL19_08995"
     CDS             complement(4348..4851)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889043.1"
                     /locus_tag="HHL19_RS08990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_08995"
                     /product="DUF5949 family protein"
                     /protein_id="WP_206325346.1"
                     /transl_table=11
                     /translation="MTTPHVLSEARSVSPLGTLTVIPWSSEVTEDSAGTPFLMAYSLGD
                     GRDGPEAGQQAMRAALESMGLSVGDRLFDLEKDAGISATLLVEAGTAVLTLPFLKVQCP
                     VPAEWQAAARETGKVYFLCSVRPWAEAVPGQPVDEDRLRAFVSDEEMLAECAHVLLPIR
                     RVQG"
     gene            5001..5399
                     /locus_tag="HHL19_RS08995"
                     /old_locus_tag="HHL19_09000"
     CDS             5001..5399
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035840.1"
                     /locus_tag="HHL19_RS08995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_09000"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_169087403.1"
                     /sec_met_domain="melC (E-value: 1.3e-37, bitscore: 124.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFTRRVALRSLFALAVTAATGGTLGRIAARPPETGTDPYAFDEM
                     YAGRRIRGLTGPAGEPVALVDGRPLHLMRCADGGWVTPLDHYESCPSPLAATRAAVDAA
                     GSAPLSRYAAGHGLHSDPTGGNPRGVHA"
     gene            5383..6249
                     /locus_tag="HHL19_RS09000"
                     /old_locus_tag="HHL19_09005"
     CDS             5383..6249
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239814.1"
                     /locus_tag="HHL19_RS09000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_09005"
                     /product="tyrosinase family protein"
                     /protein_id="WP_169087405.1"
                     /transl_table=11
                     /translation="MVYTRKNQRDLTAAERRRFVAAVLELKRRGTYDEFVRMHIDHYVA
                     DGAGRLRTAHMAPSFLPWHRKFLLEFERALRRIDATVSVPYWDWTRDSTPAASLWSEDF
                     MGGNGRRSDLQVTTGPFAYAGGKWTVKHAMTETSFLTRDFGRPRDPVTLPTTAQLDEVM
                     RERTYDTAPWNSTSPSGFRNRLEGWAPGSGNDRFRIHNRVHRWVGGLMLGGGSVNDPVF
                     WLHHSFVDLVWSRWQQRNPQAAYLPAEPPPLGDAQYRKVVARHQPMAPWGVTPAEMFDH
                     SAIYRYA"
     gene            complement(6339..6623)
                     /locus_tag="HHL19_RS09005"
                     /old_locus_tag="HHL19_09010"
     CDS             complement(6339..6623)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035838.1"
                     /locus_tag="HHL19_RS09005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_09010"
                     /product="chaplin"
                     /protein_id="WP_169087407.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVLAGTGAVALSGAGLAVADADAGAVAAGSPGVVSGN
                     VVQVPVHVPVNLCGNTVNVIGLLNPAFGNHCANVDAPNGGGNGDGGYGG"
     gene            complement(6912..7424)
                     /locus_tag="HHL19_RS09010"
                     /old_locus_tag="HHL19_09015"
     CDS             complement(6912..7424)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035837.1"
                     /locus_tag="HHL19_RS09010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_09015"
                     /product="hypothetical protein"
                     /protein_id="WP_169087409.1"
                     /transl_table=11
                     /translation="MTLRSHAGMGLLMTALASAAMAAPAAAVEAPVIVPLQGLEPVLPM
                     DAPTVATGVPVPMPGAPTGFQKGLGALPDVTLPSVPLTSTLPETVVDAPLPELLKGSEP
                     GRALLASPHSEMKAATPGATLGHPVEAPRGNGLAGLPKLADPKLGLIAPTLSGALDSQL
                     GLAPERG"
     gene            complement(7548..8402)
                     /locus_tag="HHL19_RS09015"
                     /old_locus_tag="HHL19_09020"
     CDS             complement(7548..8402)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS09015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_09020"
                     /product="hypothetical protein"
                     /protein_id="WP_169087411.1"
                     /transl_table=11
                     /translation="MRSIISRKVLTAAAATGLLSLTGGLALAANAHPGTGDTPGPGNGQ
                     AHAPLSPELCGAGMDLGDYVTSVVGDLCAHATEEPDGGYGDEPTTPPTTHPPTTPPHTH
                     PPTTPPGECEEGEPGCEPTTPPTTHPPTTAPPTTQPPTTPPGECEEGEPGCEPTTPPTT
                     HPPTTAPPTTQPPTTPPGECEEGEPGCEPTTPPGECEEGEPGCEPTTPPGECEEPEPGE
                     EPEPGCEPTTPTTPPHGPDKPELPDTGSDPALWGAAAVSAALIIGGTVVQLRGGRLVRS
                     RRH"
     misc_feature    8543..8557
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.45"
                     /tool="antismash"
     gene            complement(8564..8836)
                     /locus_tag="HHL19_RS09020"
                     /old_locus_tag="HHL19_09025"
     CDS             complement(8564..8836)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239811.1"
                     /locus_tag="HHL19_RS09020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_09025"
                     /product="hypothetical protein"
                     /protein_id="WP_169087413.1"
                     /transl_table=11
                     /translation="MKPTKVAAVVAGSLMALGVAAPAMAQEALMPTSLNGGLEAIAANG
                     LKTDVLSSTTEGSPVKSVTDTATQLNQSGKGLPLVGGLPVNPLGG"
     gene            complement(9078..9923)
                     /locus_tag="HHL19_RS09025"
                     /old_locus_tag="HHL19_09030"
     CDS             complement(9078..9923)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660307.1"
                     /locus_tag="HHL19_RS09025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_09030"
                     /product="hypothetical protein"
                     /protein_id="WP_206325347.1"
                     /transl_table=11
                     /translation="MRPLVTRPLTALAISAALTLGAAGPAFADEHRPSRAADRAAHAPL
                     PDAAALLTRTKALADVGGVTTPVTELLTAALKADEGQLPAADAEALKAKIQAAVDQAKE
                     TAPAPLPETPATPEPPVTPPVVDTPVAPPVVEAPVAPPAAEAPAGLPVKPPVTLPVAAG
                     AKAAPAAQAAPADLVDDALGTVEKAVAGLVAAVTSGDAGGVVPQVTATLTSLVNLVVAT
                     VLGSGLPAPDLAGLPALPSLPVDPPVELPVDPPELPVDPPVDAPELPVDAPVKPPLPVR
                     "
ORIGIN
        1 tgggcggcgg gcgtctcgga cgcgggcgtc cagtcgttgc ccttccagtc cgtgaggtgc
       61 gcgggcgccg tctcggtcat gccctcccac cacacgtcgc cgtcgtcggt gagcgcgacg
      121 ttggtgaaga cggagttgcc ccacatggtc ttcatggcgt tggcgttggt gtgctcgccg
      181 gtgccgggcg cgacgccgaa gaagccggcc tcggggttga tggcgtagag gcggccgtcc
      241 tcgccgaagc gcatccaggc gatgtcgtcg ccgatggtct ccacggtcca gccggggacg
      301 gtcggctcca gcatggcgag gttggtcttg ccgcaggccg acgggaaggc ggcggcgacg
      361 tacttcgcct cgccctgcgg cggggtgagc ttgaggatga gcatgtgctc ggcgagccag
      421 ccctcgtcac gggccatgac ggaggcgatg cgcagggcgt agcacttctt gccgaggagc
      481 gcgttgccgc cgtagccgga gccgtacgac cagatctcgc gggtctccgg gaagtgcgag
      541 atgtacttgg tggagttgca cggccacggc acgtcctcct ggccctccgc gaggggggcg
      601 ccgagggtgt ggacggcctt cacgaagaag ccgtcggtgc cgagctcgtc gaggacggcc
      661 tggcccatgc gggtcatggt gcgcatggag accgcgacgt aggcggagtc ggtgatctcg
      721 acgccgatgg cggagagcgg ggagccgacg gggcccatgc agaaggggac cacgtacatg
      781 gtgcggccct tcatggagcc gcggaagatg ccctcggagc ccgcgaagag ctccttcatc
      841 tccgccgggg ccttccagtg gttggtcggg ccggcgtcct cctccttctc ggagcagatg
      901 aaggtccggt cctcgacgcg ggcgacgtcg gtcgggtcgg aggcggcgta gtacgagttc
      961 gggcgcttcg ccgggtcgag cttcgtgaac gtgcccttgg cgacgagctc ctcgcacagg
     1021 cgctcgtact cggcctcgga gccgtcgcac cagacgatgc tgtccggctg cgtgatctcg
     1081 gcgatctcgt tcacccagga gacgagctcc tggtgctggg tgggaagggg agccgcgttg
     1141 tcgcgcgcca cgattgctcc ttgtagaggg gtgtattccg ctgtatgccc cgtgggggcc
     1201 gcgacccgga tgcgtcgtag ctgctcatcc ggtgccgacc gcactcattt gatcatccgc
     1261 tggaaacgcc catatgtcca ggggggtgca cacgtgagca tcgccactcg tatccggcac
     1321 ctacggggcc gtaggtacga ttccgtgtca tgactgcagc cacgccggaa gtgaccccgg
     1381 tcgagcccga accgaccgcc cagaccccgt cgctcccgct gaagccacga ctcaggggct
     1441 ggctgcacgc gggcatgttc cccgccgtga tcgtcgccgg actggtcctc gtcgccctcg
     1501 ccgactcccc ccgcgcccgg atcgcctgcg gggtctacgt cctcaccgcc tgcctgctct
     1561 tcggcatcag cgcgctctac caccgcggca actggggccc gcgcggcgag gccgtcctgc
     1621 gccgcctcga ccacgccaac atcttcctga tcatcgcggg cacctacacc ccgctcaccc
     1681 tgctgctgct cccggactcc accgcgaagc cgctcatgtg ggcggtctgg gccgccgcgg
     1741 ccgccggcat cgccttccgc gtcttctggg tcggcgcccc ccgctggctc tacaccccct
     1801 gctacatcgc catgggctgg gccgccgtct tcttcctccc cgacttcatg cggaccggcg
     1861 gcatcgccgt cctcgtcctg gtcgtcgtcg gcggcctgct ctacagcgcc ggcggcgtca
     1921 tctacggcat gaagcgcccg aacccgtccc cccgctggtt cggcttccac gaggtcttcc
     1981 actccctcac cctcgccgcc ttcatcgtcc actacgtcgg catctccctg gtcgcctacc
     2041 agtcctgacc agggatgaca cgacagaatg accccatggc cagtggtctg agggaacgca
     2101 agaagcagaa gacccgcgcg gcgatccgcc gggccggacg acggatcgcc gccgcccacg
     2161 gctgggaggc cgccaccatc gagcgcatcg ccgccgaggc cgaggtctcc ccctccaccg
     2221 tcgtccgcta cttccccgtc cgcgaggaca tcctcctcac cgacgaggac gacgagcgcc
     2281 tcgaagccct gctgcgcgcc cgcccggccg gcgaggaacc cctcgaatcc ctccgcgcgg
     2341 tcgtcgtcga ggccatcggc gcggccctgg ccgccgaccc ggaggagctc agggtccgcg
     2401 cccggctgat ggccggcacc cccgccgtcc gcgcccggct caccgagacc accgccgaga
     2461 ccggccgccg gctcgcccgc gccctcgccg accgcaccgg ccgcgccccc gacgacctgg
     2521 aggtccgggt cttcgccgcc gccgtcctcg gcgccctgcg cgaggccgtc ctctactggg
     2581 ccgagcgcgg cctcgccgag gacctcacgg cgctgctgca ccgcaccctc gacaccctca
     2641 aggccgggcc gtcgctccca gcgcgcccct gaccacctcg gccgagcgcg gattggccgc
     2701 acacccccac accccgtgcg ggcagtagtc ggtcaccgtc tggtagacgg gccggtggag
     2761 ggcgaaccag tcgagcatcc cccgcacgta cgccgggttg tccccgttcc ggaagagccc
     2821 ccactccggg tacgagacgg gcttgccgtg ctccttcgcg aaggccacgt ggtgcgcgag
     2881 cccgtactcc tcgctcacct gctcctcgaa ggagaccccc tcgggctggt cgtaggcgtc
     2941 catcccgatg atgtcgacga cgtcgtcccc cggatagcac tccggccacg gcacggcgtc
     3001 ccgcccccgg ctcggcgtga agtcgaagcg gaaccgctgc ccctcgacct cgcgcagcac
     3061 cccgaccacc tgccgccagt acgccttcca ggccgccggg tccggcccgc agcgatgccc
     3121 gtacgtggtg ccgttcatct cccagccgag caccaggacc gcgtccccga gcccgtgctc
     3181 caccagcccc tcgcccagcg cctcgaagtg cgcgtcgaag gcgccgcccg ccccgtgccg
     3241 cagcccctcc cgcacctcgg cgtcgctcag cccggcctcg ttgcggtcca tcatcggcac
     3301 gttcagcacg aagagccgcc ccggccgccc ggccttccac cgcgcccagg gcgcgaagag
     3361 ctcccggtgc ccctcgatgt tggaccagcg gtcgcccggc agataggtgt gcccgaccgt
     3421 cagctccccg ccgcccagcc acgcctccgc cccggcgatc cgccgcaccc cctccgcgtc
     3481 ggagccggtg aagaagccgg acggcacccc gggcagcggc gagggctcgg gcgcggtcgc
     3541 ggtcccggtg tgccgctcgc ccggcgcgag ccggccgacg atcccgggcg cgagcacgag
     3601 cgcggcgacg gccgcgagca gcaccaggag tgcggcccgc ggccgggaac gggggcggag
     3661 acggctcacg tcagctggtc cagaactccc accagcgggt caggatcagc atcccgatga
     3721 tcccgatgtg cagcaccggc ggggcgaagg cgaagtcgcc gaggaagccc cgcaccgccg
     3781 ccggggcggg cagcaccccg gtccgcacgt tgtgcgcggt gacgtaccag aacatggtga
     3841 tcgtcgccgt ccaggcgagg cagcaccaca ggcagagggc gttgatctcg tacagcgact
     3901 gctgcatcag ccaggtgcag aagccgacgc cgagcagcat cccaccgttc agccccagcc
     3961 agaaccaccc ccggtgccgg gcccccgcca ggagcccggc gccgatcgcg aggacgacgc
     4021 cgtacgtgac gaggccgagc atcgggttgg ggaagccgaa gaccgccgcc tgctcgctct
     4081 tcatgatgtt cccgcaggac acgaccgggt tcaggctgca ccccggctgg aagcccgggt
     4141 cctccaggag cttgaacttg tcgatcgtga tcacccacgc ggccaggatc ccggccgcgc
     4201 ccgtgaccac gagcagccag ccgagccccc ggcccgcgcc gaccgtgccg tcctccgacc
     4261 gcaggtcccg cgccgcgcgg tcctcccgcc gctgtcccgg gaccccgctc cgtaccccga
     4321 gcgtcgtcat cgcgccgccc cttccgttca gccctgcacg cgccggatcg gcagcaggac
     4381 gtgggcgcat tccgcgagca tctcctcgtc ggagacgaag gcgcgcagcc ggtcctcgtc
     4441 cacgggctgc ccggggaccg cctcggccca cgggcgcacc gagcagagga agtagacctt
     4501 gccggtctcg cgggcggcgg cctgccactc ggccggcacc gggcactgca ccttcaggaa
     4561 gggcagggtg aggacggcgg tgccggcctc gacgagcagc gtggcgctga tccccgcgtc
     4621 cttctccagg tcgaagagcc ggtctccgac cgagaggccc atcgactcca gggcggcgcg
     4681 catggcctgc tgcccggcct ccggaccgtc ccggccgtcg ccgagcgaat acgccatgag
     4741 gaaaggcgtg ccggcggagt cttcggtgac ttcgctggac cacggaatca ccgtgagcgt
     4801 gcccagcgga gagacgctgc gcgcctcgga aaggacatgg ggagtggtca tggaacggga
     4861 tgctagtggg gcaaccaccc tttccccgta ccgaattcac tcatccggcc gacattcccc
     4921 cgctcgaact cccggccgca acgaacacgg gttttcatcg ttgtgccctg aggccccttg
     4981 tcgacaccag gagatcgccg atgcccttca cgcgccgtgt cgccctccgg tcgctgttcg
     5041 cgctggccgt caccgccgcc accggcggga ccctcggccg gatcgccgcc cgccccccgg
     5101 agacggggac ggacccgtac gccttcgacg agatgtacgc gggccgccgg atccgcggcc
     5161 tcaccggacc ggcgggcgag ccggtggcgc tggtggacgg gcggccgctg cacctgatgc
     5221 gctgcgccga cggcggctgg gtgaccccgc tggaccacta cgagtcctgt ccgagcccgc
     5281 tcgcggccac ccgcgcggcc gtggacgcgg cggggtcggc ccccctctcc cggtacgcgg
     5341 cggggcacgg cctccactcc gacccgacgg gagggaaccc gcgtggtgta cacgcgtaag
     5401 aaccagcgcg acctgacggc ggccgagcgc cgccggttcg tcgccgcggt gctcgaactg
     5461 aagcgccgcg gcacgtacga cgagttcgtc cggatgcaca tcgaccacta cgtcgccgac
     5521 ggcgccggcc ggctgcggac cgcccacatg gcgccgagct tcctgccctg gcaccggaag
     5581 ttcctcctgg agttcgagcg ggcgctgcgc cggatcgacg cgacggtttc ggtcccgtac
     5641 tgggactgga cccgggactc gaccccggcg gcctcgctct ggtcggagga cttcatgggc
     5701 ggcaacggcc gccgctcgga cctccaggtg accaccggcc ccttcgccta cgccgggggg
     5761 aagtggacgg tgaagcacgc gatgaccgag acctccttcc tgaccaggga cttcggccgt
     5821 ccgcgcgatc cggtcacgct gccgacgacc gcccagctgg acgaggtgat gcgggagcgg
     5881 acgtacgaca cggccccgtg gaactcgacc agcccctcgg gtttccgcaa ccgcctggag
     5941 ggctgggccc cgggctcggg caacgaccgg ttccggatcc acaaccgggt gcaccgctgg
     6001 gtgggcggtc tgatgctcgg cggcggttcg gtgaacgacc cggtgttctg gctgcaccac
     6061 tccttcgtgg acctggtgtg gtcgcggtgg cagcagcgca atccacaggc cgcctatctg
     6121 ccggcggagc cgccgccgct gggcgacgcg cagtaccgga aggtggtggc acggcaccag
     6181 ccgatggcgc cgtggggcgt gacgccggcc gagatgttcg accacagcgc gatctaccgg
     6241 tacgcctgac ggggcggggc ggggcggggg aggccccgga cgcgggcgtc cccccggccc
     6301 tggaggggcc ggggggacgc tcgggggaag cggggcggtc agccgccgta gccgccgtca
     6361 ccgttgccgc cgccgttcgg ggcgtcgacg ttggcgcagt ggttgccgaa ggccgggttc
     6421 agcaggccga tgacgttgac ggtgttgccg cagaggttga ccgggacgtg gaccgggacc
     6481 tggacgacgt tgccggagac aacaccgggc gagccggcgg cgacggcgcc ggcgtcggcg
     6541 tcggcgacgg ccaggccggc tccgctgagg gcgacggcac cggtgccggc cagaacggcg
     6601 gcagccttcg cgatgcgaga catcagaact ccttggatgg gtcgagcgac cgcagggatc
     6661 acggccgtca cgtgcgttca acgccgtacc acggagcggg tcacggcgat tgagccgaaa
     6721 aggtggcccg cggtccgatg accgcccccc gtcggatacg agaggtggca ctccggaccg
     6781 cggaccgtgg ccatgcgaca agccttccgg tgcaacgagg aaaggccctt gcggtagcgg
     6841 ggaagaatcg tgtcttcact cgcgcggaac gcgcccgaac ggaattccga aaagggcggg
     6901 ggaagggggt ttcagccgcg ctcgggagcg aggccgagct gggagtcgag ggccccgctc
     6961 agcgtcgggg cgatgaggcc gagcttcgga tcggcgagct tgggcagtcc ggcgaggccg
     7021 ttgccccggg gggcctcgac cgggtggccg agggtggcac cgggggtggc ggccttcatc
     7081 tcggagtgcg ggctggcgag gagcgccctc cccggctcgc tgcccttcag gagctcgggg
     7141 agcggggcgt ccacgacggt ctcgggcagg gtgctggtga gcgggacgga cggcagggtc
     7201 acgtcgggca gcgcgccgag gcccttctgg aagccggtgg gggcgccggg catgggcacc
     7261 ggcacgccgg tcgcgacggt cggggcgtcc atcggcagga ccggctccag gccctggagg
     7321 ggaacgatca ccggggcctc gacggcggcg gccggggcgg ccatggcggc ggaggcgagc
     7381 gcggtcatga ggagtcccat gccggcgtga gagcgcagag tcatgccggg tgaacgagcc
     7441 actcggccga aacgtcgcgc gtggttcccc catgtgcagc aacgccggag gcccccaccg
     7501 gtgagggcgg gggcctctgt tgacgtcacg tcaggcaggc gcgtacgtca gtggcgacgg
     7561 ctccggacga ggcggccgcc ccggagctgg acgacggtgc cgccgatgat gagggcggcg
     7621 ctgacggcgg ccgctcccca cagggcgggg tcgctgcccg tgtcggggag ttcgggcttg
     7681 tcgggcccgt gcggcggggt ggtcggcgtg gtgggctcac aaccgggctc gggctcctcg
     7741 ccgggctcgg gctcctcgca ctcaccggga ggcgtggtgg gctcacaccc cggctcgccc
     7801 tcctcgcact cacccggcgg cgtggtgggc tcacaccccg gctcgccctc ctcacactca
     7861 cccggcggcg tggtcggggg ctgggtcgtg ggaggcgccg tggtcggcgg gtgcgtcgtc
     7921 ggcggtgtgg tgggctcaca ccccggctca ccctcctcac actcacccgg cggcgtggtc
     7981 gggggctggg tcgtgggagg cgccgtggtc ggcggatgtg tcgtcggcgg tgtggtgggc
     8041 tcgcaccccg gctcaccctc ctcacactca cccggcggcg tggtcggcgg gtgcgtgtgc
     8101 ggaggcgtcg tcggcggatg tgtcgtgggc ggcgtggtgg gctcgtcgcc gtagccgccg
     8161 tcgggttcct ccgtcgcgtg ggcgcagagg tctccgacga ccgacgtcac gtagtcgccc
     8221 aggtccatgc cggcgccgca gagttccggc gagagagggg cgtgcgcctg cccgttgccg
     8281 ggtcctggcg tgtcgcccgt gccggggtgc gcgttcgcgg ccagtgcgag accgccggtc
     8341 agcgacagca agccggtcgc tgccgccgcg gtgagtactt tcctgctgat gatggaccgc
     8401 ataccgctct tcctcgggag aaagggagag accggcgagg atcccccctc gctccgtccg
     8461 gccgcgtccc acgctgacgt tcgcgaggga cggtcccgag agtagggagc ggcacaccgt
     8521 gtgaggtcga ggccacacgg cgaccggtca gaaaatcatt cgatcagccg ccaagcgggt
     8581 tgaccgggag gccgccgacg agcgggaggc ccttgccgga ctggttcagc tgggtcgcgg
     8641 tgtcggtgac cgacttgacc ggggagccct cggtggtgct gctgagcacg tccgtcttca
     8701 gcccgttggc ggcgatggcc tccaggccgc cgttcaggct ggtcggcatg agtgcctcct
     8761 gggccatggc gggggcggcg acgccgaggg ccatgagaga accggcgacg accgcggcga
     8821 ccttggtggg cttcatgggg agaatccttc ctctgttctt tcaactcgcg ttccgcacag
     8881 gcttcttgat gaattccgtg cgtcgcttcc gtcttctgta acgagaggtg ggctccccgg
     8941 aaactccagg agcagggatt tctcgacact gcacccgatc gaaggggacc ggtgcgattt
     9001 ccggatgacc ggacacggac gcgcccgtac cggcccggcg gaaggccgga ccggtacggg
     9061 tcgggggtgc gcgcgggtca gcggaccggc aacggcggct tcaccggcgc gtcgaccggc
     9121 agctccggtg cgtcgaccgg cgggtcgacg ggcagctccg gcgggtcgac gggcagttcg
     9181 acgggcgggt cgaccgggag cgagggcagc gcggggaggc cggccaggtc cggggcgggc
     9241 agcccgctgc cgagcacggt ggcgacgacg aggttgacca gggaggtcag cgtggccgtg
     9301 acctgcggga cgactccgcc ggcgtccccg gaggtgacgg cggcgaccag cccggcgacg
     9361 gccttctcga cggtgccgag cgcgtcgtcc accagatcgg ccggcgcggc ctgcgcggcc
     9421 ggcgcggcct tggccccggc cgcgacgggc agggtcaccg gcggcttcac gggcagcccg
     9481 gccggggcct cggcggccgg cggggcgacg ggggcctcga ccacgggcgg ggcgaccggg
     9541 gtgtccacga cgggcggggt gaccggcggc tccggggtgg ccggggtctc cggcagcggg
     9601 gcgggggcgg tctccttggc ctggtcgacg gcggcctgga tcttcgcctt cagggcttcg
     9661 gcgtcggccg cggggagctg gccttcgtcg gccttgaggg cggcggtgag gagttcggtc
     9721 acgggggtcg tcacaccgcc gacgtccgcg agggccttgg tccgggtcag cagggcggcg
     9781 gcgtcgggga gcggggcgtg ggcggcccgg tcggccgcgc gggagggacg gtgctcgtcg
     9841 gcgaaggcgg gtcccgccgc gccgagggtg agggcggcgg atatcgccag ggccgtgaga
     9901 gggcgtgtga ccaggggacg catatgtgtt ccttttcctt atgcgtcgga caacttccct
     9961 cccaccgtgc ctgcgggtat agccctccgc aaccacagaa ctactgagcg ccacgtctcc
    10021 gttcgagtga atccgccttc cgacctgccc cccgaagggg cgtacgccgt tgcaccggac
    10081 ggcgtacggg ggtgcgcccg aacgggtacc ggcccagtgg ccgcaaggaa aaagccggtg
    10141 cgcccgcccc gaggggtggg cgcaccggct tcggaaggac cgatccgacg tgcgaggtca
    10201 gacgttggcg cagaagttgc cgaaggccgg gttgagcgcg ccgatgacgc tcacggtgtt
    10261 gccgcagacg ttgaccggca cgtggaccgg gacctgcacg acgttgccgg agccgacacc
    10321 gggggacttc acggcggcgc cctctgcgat ggagtcggcg gcggcggcac cggcggcacc
    10381 ggcgaccgcg gcggcggca
//
