LOCUS       NZ_JABBGE010000002     20369 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. R302 contig2, whole genome shotgun sequence.
ACCESSION   NZ_JABBGE010000002
VERSION     NZ_JABBGE010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. R302
  ORGANISM  Streptomyces sp. R302
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 777377)
  AUTHORS   Dahal,R.H.
  TITLE     Streptomyces sp. R302 sp. nov., isolated from soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 777377)
  AUTHORS   Dahal,R.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) Life Science, Kyonggi University, Kyonggi
            University, Suwon, Gyeonggi-Do 16227, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2020
            Assembly Method                   :: SPAdes v. APR-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 180.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012927245.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 03:52:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,357
            CDSs (total)                      :: 7,271
            Genes (coding)                    :: 7,075
            CDSs (with protein)               :: 7,075
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 1, 1, 3 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 84 of 196
            Pseudo Genes (incomplete)         :: 164 of 196
            Pseudo Genes (internal stop)      :: 20 of 196
            Pseudo Genes (multiple problems)  :: 67 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:44:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 102613
            Orig. end                         :: 122982
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBGE010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20369
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20369
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20369
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10369](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10369
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    204..222
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.89"
                     /tool="antismash"
     gene            238..936
                     /gene="ureA"
                     /locus_tag="HHL19_RS06455"
                     /old_locus_tag="HHL19_06455"
     CDS             238..936
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_process="GO:0019627 - urea metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ureA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946715.1"
                     /locus_tag="HHL19_RS06455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06455"
                     /product="urease subunit gamma"
                     /protein_id="WP_169086532.1"
                     /transl_table=11
                     /translation="MRLTPTERDRLLLFGAAELARARRARGLRLNVPEATALVADTVCE
                     AARDGRRLAEAIEAARSVLGPEDVLPGVADVVTEVHVEAVFDDGSRLAVVTDPIGGGTL
                     GAGAPGALLPGPGHPEPEPALTLAVRNTATVPVSVTSHFHFFEANPRLDFDRAAAYGMR
                     LAIPAGASFRFDPGGAAEVGLVPIGGARVAIGFAGLVDGPLDAPGAKAEALRRAAACGY
                     LGVTAPKEDD"
     gene            936..2618
                     /locus_tag="HHL19_RS06460"
                     /old_locus_tag="HHL19_06460"
     CDS             936..2618
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_process="GO:0043419 - urea catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008739824.1"
                     /locus_tag="HHL19_RS06460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06460"
                     /product="urease subunit alpha"
                     /protein_id="WP_169086534.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.3e-46, bitscore:
                     154.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPYEYASVHGPRAGDRVVLGDSGLVVRVEADSQKPGEEFLAGFG
                     KTARDGLHLKAAAVRETCDVVISNVLLIDAVQGIRKVSVGIREGRIHAIGRAGNPDTLD
                     GVDVVVGTGTSIVSGEGLIATAGAVDTHVHLLSPRIMEASLASGVTTIIGQEFGPVWGV
                     GVNSPWALHHAFNAFDAWPVNIGFLARGSSSDPAPLVEALAEGGASGFKVHEDMGAHTR
                     ALDTALRVAEEHDVQVALHSDGLNECLSVEDTLAVLEGRTIHAFHIEGCGGGHVPNVLK
                     MAGVPNVIGSSTNPTLPFGRDAVAEHYGMIVSVHDLKTDLPGDAAMARDRIRAGTMGAE
                     DVLHDLGAIGITSSDAQGMGRAGETVRRTFAMAGKMKAELGPLEGDGAHDDNARVLRYL
                     AKLTINPAIAHGLAHEIGSVEVGKLADIVLWRPEFFGAKPQMVLKAGFPAWGVTGDPNA
                     ATDTCEPLVLGPLFGAHGAAAADLSVAFVAQAAVDLGGDRMPTRRRRVPVRGTRGIGPA
                     DLLLNSRTGSVQVDDRTGLVSLDGSPIRSEPADSVSLNRLYFL"
     gene            2630..3652
                     /locus_tag="HHL19_RS06465"
                     /old_locus_tag="HHL19_06465"
     CDS             2630..3652
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266761.1"
                     /locus_tag="HHL19_RS06465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06465"
                     /product="agmatine deiminase family protein"
                     /protein_id="WP_169086536.1"
                     /transl_table=11
                     /translation="MTSYRMPAEWTPHERTWMAWPSPNPTFTSDEELAEARGAWAAVAR
                     AVRRFEPVTMVVAPGDAEGARELLGEDVELVERELDDAWMRDIGPTFVKDAEGRLAAVD
                     WVFNGWGAQDWARWEHDSKIARHVADAAEVPVLSSELVNEGGGIHVDGEGTVLLTDTVQ
                     LGSGRNPEWSREQVEREIHAKLGTTRAIWLPHGLAGDYGLYGTQGHIDIVAAFARPGTV
                     LVHSQQDPRHPDYGRSRLYADILRAQTDAQGRPLEVIEVPAPTVLTDEEGDWVDYSYIN
                     HYLCNGAVILCAFDDPHDELAAEIFRRLFPDREVVLVDARTIFASGGGIHCITQQQPAV
                     "
     gene            complement(3695..4231)
                     /locus_tag="HHL19_RS06470"
                     /old_locus_tag="HHL19_06470"
     CDS             complement(3695..4231)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127801.1"
                     /locus_tag="HHL19_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06470"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_169086538.1"
                     /transl_table=11
                     /translation="MTVRTAPTHELGAERLTAVRALLDAAFDGDFSAEDWDHTLGGVHA
                     WIEDATGLLAHGAVVQRRVLHRGRSYRTGYVEGVAVRADARRRGFGGAVMDALERVIDG
                     THRFGALSASDEGAALYRARGWEVWGGRIEVLGPDGTVPLPEEEGGVFVRPAGGLALPD
                     PTAPLVFDWRDGDAV"
     gene            4353..5234
                     /locus_tag="HHL19_RS06475"
                     /old_locus_tag="HHL19_06475"
     CDS             4353..5234
                     /NRPS_PKS="Domain: Abhydrolase_1 (28-275). E-value: 9e-40.
                     Score: 128.7. Matches aSDomain:
                     nrpspksdomains_HHL19_RS06475_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236003.1"
                     /locus_tag="HHL19_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06475"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_169086540.1"
                     /sec_met_domain="PF00561 (E-value: 3.6e-29, bitscore: 97.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.9e-11, bitscore:
                     39.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLPTRHRTVTVRGHEIFYREAGPADAPVLLLLHGFPTSSHMFR
                     DLIPRLADRYRLIAPDHLGFGRSAAPSADAFAYSFAELAALTGEFTEALGLDRFAIYIQ
                     DYGAPIGLRLALAHPERITAVVTQNGNAYEEGLGTEAWAPVLALIADRTPETEAPVRAI
                     RSLDGIRWQYETGVPAAYRDRLSPDAWHHDAALMAREGQDGIQLGLIADYGSNFALYPA
                     FQEWFRTSRVPLLAVWGEGDEVFVPAGAEAFRRDLPDAEIHLLPTGHFALETHAPRVAE
                     LIGDFLERHVTA"
     aSDomain        4437..5177
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHL19_RS06475_Abhydrolase_1.1"
                     /evalue="9.00E-40"
                     /label="HHL19_RS06475_Abhydrolase_1.1"
                     /locus_tag="HHL19_RS06475"
                     /protein_end="275"
                     /protein_start="28"
                     /score="128.7"
                     /tool="antismash"
                     /translation="PVLLLLHGFPTSSHMFRDLIPRLADRYRLIAPDHLGFGRSAAPSA
                     DAFAYSFAELAALTGEFTEALGLDRFAIYIQDYGAPIGLRLALAHPERITAVVTQNGNA
                     YEEGLGTEAWAPVLALIADRTPETEAPVRAIRSLDGIRWQYETGVPAAYRDRLSPDAWH
                     HDAALMAREGQDGIQLGLIADYGSNFALYPAFQEWFRTSRVPLLAVWGEGDEVFVPAGA
                     EAFRRDLPDAEIHLLPTGHFALETH"
     gene            complement(5323..6954)
                     /gene="pruA"
                     /locus_tag="HHL19_RS06480"
                     /old_locus_tag="HHL19_06480"
     CDS             complement(5323..6954)
                     /EC_number="1.2.1.88"
                     /GO_function="GO:0003842 - 1-pyrroline-5-carboxylate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006562 - proline catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pruA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311510.1"
                     /locus_tag="HHL19_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06480"
                     /product="L-glutamate gamma-semialdehyde dehydrogenase"
                     /protein_id="WP_169086542.1"
                     /sec_met_domain="Aldedh (E-value: 6.2e-104, bitscore:
                     343.4, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAVTQVPAPVNEPVHGYAPGSPERARLEAKLKELADNPRELPMT
                     IGGVKRMGGGERVDVVQPHNHKSVIGTFAGATQQDAQDAIDAALAAAPAWRAMSFDDRA
                     AIILRAAELLAGPWRETLAASTMLGQSKTAQQAEIDTPCELVDFWRFNVAYARQILAEQ
                     PPANSPGVWNRLDHRPLEGFVYAITPFNFTAIAGNLPTAPALMGNVVVWKPSPTQTHSA
                     VLLMELLEEAGLPKGVINLVTGDGIAVSEVALNHRDLAGIHFTGSTKTFQHLWKTVGTN
                     IEKYRSYPRIVGETGGKDFVVAHPSADRAVLKTALTRGSFEFQGQKCSASSRAYIPASI
                     WNDGFKEEFAAEVDGIAMGDVTDLSNFIGAVIDDRSFAKNKAAIDRASSDPSCTIIAGG
                     TYDDSEGYFVRPTVIACTDPENEVFKAEYFGPILAIHVYEDDQYDAMLEQMESVSDYAL
                     TGAVISNDRAAAAHTMEKLRFAAGNFYINDKSTGAVVGQQPFGGGRASGTNDKAGAPQN
                     LMRWTLTRAIKETLVPPTEYGYPHMG"
     gene            complement(6990..7916)
                     /locus_tag="HHL19_RS06485"
                     /old_locus_tag="HHL19_06485"
     CDS             complement(6990..7916)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960086.1"
                     /locus_tag="HHL19_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06485"
                     /product="proline dehydrogenase family protein"
                     /protein_id="WP_169086544.1"
                     /transl_table=11
                     /translation="MLGPVILAASRSDKMRRLVSAAPGTKQVVARFIAGEIVDDVVPIV
                     RDLTARGLEVTLDVVGEDITTVEQSYAARDAYLELIGRLKELGLGERAEMSVKLSMFGQ
                     SLEKGHELALANVRPVVAAAAEIGTTVTLDAEDHTTLDSMFAIHEELRKDFPQTGCVIQ
                     AYLFRTEEDARRLAANGSRVRIVKGAYKEPAEVAIQDKPEIDKAYVRIMKILMDGEGYP
                     MIGSHDPRLIAIGQELARRAGRKLDEYEFQMLYGIRSEEQNRLAAEGHRMRVYTAYGTD
                     WYGYFMRRLAEKPANLLFFVRSILTKG"
     misc_feature    complement(8070..8084)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.28"
                     /tool="antismash"
     gene            8112..9446
                     /locus_tag="HHL19_RS06490"
                     /old_locus_tag="HHL19_06490"
     CDS             8112..9446
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961951.1"
                     /locus_tag="HHL19_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06490"
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_169086546.1"
                     /transl_table=11
                     /translation="MKGDYQELVDEISTLLGTPATLENRDFGLIAFGAHDSDDDSAMDP
                     VRTRSILTRKSTPAVRAWFEGFGITRATGPVRIPAAPDAGVYRDRICLPVRHRGVVLGY
                     VWLLDAEPGPSHERLTAAMEVAARIGELLADEERAGADLSRELRAVLTAERGWQYDMAV
                     AALRTALGPDADGLHALVCVAPWTGEDSPSPRTVPGAAVVCALPWRGPGGPYAGAPGRD
                     SEAGASRGEAVHGPGPARGARAASGGTGSARGTAPGHGPSSGAPSDGGYAPGPGPQRAL
                     AVLVRLRSGDNLSPATTAAGRLRGTAGQAAVAGIAAPRRGLGELDLSWREASAAARTAH
                     SQPRLGPLAHWSELGAYRLLTALPQAEPDPAVRALLAPAHTELARTAEVFLDHAGQAGR
                     TAAALGIHRQTLYYRLSRVEQLTGLDLDSGEDRLLLHMALKAARL"
     gene            complement(9457..9930)
                     /locus_tag="HHL19_RS06495"
                     /old_locus_tag="HHL19_06495"
     CDS             complement(9457..9930)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="HHL19_RS06495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06495"
                     /product="MFS transporter"
                     /protein_id="WP_346768473.1"
                     /transl_table=11
                     /translation="MSTVGVAGLALLPPVPVLVACAVLAGVGAGPLPALFLVLVGERVP
                     EEVRGRVLGLQNAVSMTAVPVSTLLAGLVVERAGLRETGVALGIAWCAVSVLLLVVPAM
                     RGLDGPEGGGADETEDADEDGAAAAGVPRPATAPDTGPAPEPAPGPATVPRAE"
     gene            10001..10369
                     /locus_tag="HHL19_RS06500"
                     /old_locus_tag="HHL19_06500"
     CDS             10001..10369
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Bottromycin_Methyltransferase_RRE"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000049: Methylation (67% identity)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHL19_RS06500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HHL19_06500"
                     /product="hypothetical protein"
                     /protein_id="WP_206325475.1"
                     /sec_met_domain="Bottromycin_Methyltransferase_RRE
                     (E-value: 4.8e-28, bitscore: 92.6, seeds: 12, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLWRAQYRRASFTYRLGFDSVTLTDRRPGLPAEDTVLTGDDARL
                     YRAVIGGARHRDLTGGDPERVRATLAGWERRRWVHSEGTKVIALATRATPSAYRTPPPK
                     GTPRRARTPVPLTLTTRP"
     aSDomain        10040..10252
                     /aSDomain="Bottromycin_Methyltransferase_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing methyltransferase protein in a
                     bottromycin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHL19_RS06500_Bottromycin_Methyltrans
                     ferase_RRE.1"
                     /evalue="1.90E-29"
                     /identifier="RREFam008.1"
                     /label="HHL19_RS06500"
                     /locus_tag="HHL19_RS06500"
                     /protein_end="84"
                     /protein_start="13"
                     /score="92.6"
                     /tool="antismash"
                     /translation="TYRLGFDSVTLTDRRPGLPAEDTVLTGDDARLYRAVIGGARHRDL
                     TGGDPERVRATLAGWERRRWVHSEGT"
     gene            10649..11137
                     /locus_tag="HHL19_RS06505"
                     /old_locus_tag="HHL19_06505"
     CDS             10649..11137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018839044.1"
                     /locus_tag="HHL19_RS06505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06505"
                     /product="DUF2087 domain-containing protein"
                     /protein_id="WP_240981488.1"
                     /transl_table=11
                     /translation="MVGLLAQDDRRSAYAALVLGATSLPQVAERTGLRPAAAAMALQKL
                     VEGRIACHDPEGGYTLLDDTFRLAVREEVRLTGRGGGDGAGAYFRKGRLTSIPGKAEVR
                     RRVLTVVADSFEKGTVYEESKVNAVCGGWLDDWVSLRRALVDEGLLLRDDATARYQRA"
     gene            11151..12593
                     /locus_tag="HHL19_RS06510"
                     /old_locus_tag="HHL19_06510"
     CDS             11151..12593
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000048: Hydrolysis (72% identity)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003255.1"
                     /locus_tag="HHL19_RS06510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06510"
                     /product="leucyl aminopeptidase family protein"
                     /protein_id="WP_169086552.1"
                     /transl_table=11
                     /translation="MTLIRAGAVDEPADVVALPRHTAAEAGAFARRRGFLGRVGQVVAE
                     PSADGRGVLLHVGLGPAATADVAALRQAAAAAVRAAGPARTVRLDLALTERTGVTAADR
                     VAAVTEGARLALYRFDGFRTGRGQPPPAELRVTGDRPAALAAALAAAEGTCLARDLVNS
                     PPGALTPAAFARRIETEAAAAGLSCAVYEGQDLARLDLAGLTAVSRGSAEPARYVELVY
                     EPTGPAALTVALVGKGVTFDSGGLSLKPSGELHTMKADMAGAAAVLGALVALPRLGLPV
                     RVRAHLPLAENMPDGGALRVGDVVRHLDGTTTEITHTDNEGRVVLADVLLRASAPGAAD
                     VVLDVATLTSAAVHALGTRTGAVFSPDDGLAELVRRAGERAGESLWRLPLLAHERRRLR
                     SAVADRVNCSHRHGDTVQAALYLSEFLAPGTRWAHLDIAAPAWNDEPPYGEVPHGATGF
                     GVRTLLETLRALTAGAADPAGY"
     gene            complement(12631..14220)
                     /gene="serA"
                     /locus_tag="HHL19_RS06515"
                     /old_locus_tag="HHL19_06515"
     CDS             complement(12631..14220)
                     /EC_number="1.1.1.95"
                     /GO_function="GO:0004617 - phosphoglycerate dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006564 - L-serine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="serA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036375.1"
                     /locus_tag="HHL19_RS06515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06515"
                     /product="phosphoglycerate dehydrogenase"
                     /protein_id="WP_169086554.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 7.4e-63, bitscore:
                     206.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSKPVVLIAEELSPATVDALGPDFEIRHCNGADRAELIPAIADV
                     DAILIRSATKVDAEAIAAAKKLRVVARAGVGLDNVDVSAATKAGVMVVNAPTSNIVTAA
                     ELACGLLVATARNIPQANTALKNGEWKRNKYTGVELSEKTLGVVGLGRIGVLVAQRMSA
                     FGMKVVAYDPYVQPARAAQMGVKLLTLDELLEVADFITVHLPKTPETLGLIGDEALHKV
                     KPSVRIVNAARGGIVDEAALYSALKEGRVAGAGLDVYAKEPCTDSPLFELDQVVCTPHL
                     GASTDEAQEKAGIAVARSVRLALAGELVPDAVNVQGGVIAEDVKPGLPLAEKLGRIFTA
                     LAGEVAARLDVEVYGEITQHDVKVLELSALKGVFEDVVDETVSYVNAPLFAQERGVEVR
                     LTTSSESPDHRNMVTVRGTLSSGEEVSVSGTLAGPKHLQKIVAVGGYDVDLALADHMVV
                     LRYEDRPGVVGTVGRILGEAGLNIAGMQVSRTEEGGEALVVLTVDDTVPAAVIAEISTE
                     IGATSARSVNLI"
     misc_feature    14322..14331
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     gene            complement(14458..15459)
                     /gene="ilvC"
                     /locus_tag="HHL19_RS06520"
                     /old_locus_tag="HHL19_06520"
     CDS             complement(14458..15459)
                     /EC_number="1.1.1.86"
                     /codon_start=1
                     /gene="ilvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000491.1"
                     /locus_tag="HHL19_RS06520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06520"
                     /product="ketol-acid reductoisomerase"
                     /protein_id="WP_169086556.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3e-07, bitscore:
                     25.3, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELFYDADADLSIIQGRKVAVIGYGSQGHAHALSLRDSGVDVRV
                     GLHEGSKSKAKAEEQGLRVVTPAEAAAEADLIMILIPDPIQAKVYEESIAPNLKDGDAL
                     FFAHGFNVRFGFIKPPAGVDVALVAPKGPGHLVRRQYEEGRGVPAIAAVEQDATGNAFA
                     LALSYAKAIGGTRAGVIKTTFTEETETDLFGEQAVLCGGASALVKAGFETLVEAGYQPE
                     IAYFECLHELKLIVDLMYEGGLEKMRWSVSETAEWGDYITGPRVITADTKAEMKKVLTE
                     IQDGTFAKNWMDEYHGGLKKYDEYKTQDEKHLLETTGKELRKLMSWVNDEEA"
     gene            complement(15534..16058)
                     /gene="ilvN"
                     /locus_tag="HHL19_RS06525"
                     /old_locus_tag="HHL19_06525"
     CDS             complement(15534..16058)
                     /EC_number="2.2.1.6"
                     /GO_function="GO:1990610 - acetolactate synthase regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ilvN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925060.1"
                     /locus_tag="HHL19_RS06525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06525"
                     /product="acetolactate synthase small subunit"
                     /protein_id="WP_169086558.1"
                     /transl_table=11
                     /translation="MSKHTLSVLVENTPGILARIAALFSRRGFNIDSLAVGVTEHPDIS
                     RITIVVNVEDLPLEQVTKQLNKLVNVLKIVELEPSAAIQRELVLVKVRADNETRSQIVE
                     IVKLFRAKTVDVSPEAVTIEATGSGDKLDAMLKMLEQFGVKELVQSGTIAIGRGARSIT
                     DRSLRALDRSA"
     gene            complement(16094..17941)
                     /locus_tag="HHL19_RS06530"
                     /old_locus_tag="HHL19_06530"
     CDS             complement(16094..17941)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003984 - acetolactate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675168.1"
                     /locus_tag="HHL19_RS06530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HHL19_06530"
                     /product="acetolactate synthase large subunit"
                     /protein_id="WP_169086560.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 3.2e-54, bitscore:
                     178.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-49, bitscore:
                     163.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQATGHHPQPRPRSGATPAPTVEHVTGAQSLIRSLEEVGADTV
                     FGIPGGCILPAYDPMMDSEKVRHVLVRHEQGAGHAATGYAQATGKVGVCMATSGPGATN
                     LVTPIADAHMDSVPLVAITGQVASKAIGTDAFQEADIVGITMPITKHNFLVTRAEDIAK
                     TIAEAFHIASTGRPGPVLVDIAKDALQAKTTFSWPPQTDLPGYRPVTKPHAKQIREAAK
                     LISAAKRPVLYVGGGVIKSGATAELKVLAELTGAPVTTTLMALGAFPDSHPQHVGMPGM
                     HGAVTAVTALQKADLIVALGARFDDRVTGKLDSFAPYAKIVHADIDPAEIGKNRAADVP
                     IVGDAREVIADLVQAVQAEHTEGRKGDYTAWWSDLNRWRETYPLGYDLPEDGSLSPQQV
                     IQRIGQLAPEGTVFTAGVGQHQMWAAHFIDYEKPATWLNSGGAGTMGYAVPAAMGAKAG
                     MPDRTVWAIDGDGCFQMTNQELATCALNNIPIKVAIINNGALGMVRQWQTLFYNQRYSN
                     TVLHSGPDDVNPEAKGTRVPDFVKLSEAMGCVAMRCESPEDLDKVIAEANAINDRPVVI
                     DFIVHEDAQVWPMVAAGTSNDEVMAARGVRPDFGDGEDD"
     misc_feature    complement(17970..17986)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.32"
                     /tool="antismash"
     misc_feature    18192..18206
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.96"
                     /tool="antismash"
     misc_feature    complement(18481..18496)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    complement(19426..19440)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 cccaggcaga ggttggagcc gagcaggatc gcgacgaggt cgcgggggcc gctggtgcgt
       61 tcggcctcgg ggatggtgtc gactccgtgc tgttcgatcg tcgccatggg acctccgggg
      121 gagcggaagg gatgtttttg agtggcgctc aatgtgaccc gcgcctgacg ggcgagtcaa
      181 tacttggaag cattccgtcc agcatttaga gtgtcgctca aacaggaggt gcatgacgtg
      241 cgactgaccc ccacggagcg cgaccggctg ctgctcttcg gcgccgccga gctcgcccgg
      301 gcccggcggg cccgcggcct tcggctcaac gtccccgagg cgaccgccct cgtcgcggac
      361 accgtctgcg aggcggcccg cgacggccgg aggctcgccg aggccatcga ggcggcccgc
      421 tccgtcctcg gccccgagga cgtgctgccc ggcgtcgccg acgtggtgac cgaggtccac
      481 gtcgaggccg tcttcgacga cggctcccgg ctcgccgtcg tcaccgaccc gatcggcggg
      541 ggcacgctcg gcgcaggcgc gcccggcgcg ctgctccccg gccccggcca ccccgagccg
      601 gagcccgcgc tcaccctcgc cgtacgcaac acggcgacgg tcccggtcag cgtcacctcc
      661 cacttccact tcttcgaggc caacccgcgc ctcgacttcg accgcgccgc cgcctacggc
      721 atgcgcctcg ccatccccgc cggcgcctcc ttccgcttcg accccggcgg cgccgccgag
      781 gtcgggctcg tgcccatcgg cggcgcccgc gtcgccatcg gcttcgccgg cctcgtcgac
      841 gggccgctgg acgcgcccgg cgcgaaggcg gaggccctgc ggcgcgccgc cgcctgcggc
      901 tacctgggcg tcacggcccc gaaggaggac gactgatgga cccgtacgag tacgcctccg
      961 tgcacggccc ccgggccggc gaccgggtgg tcctcggcga ctccggactc gtcgtccggg
     1021 tcgaggccga ctcccagaag cccggcgagg agttcctcgc cggcttcggc aagaccgccc
     1081 gcgacggcct ccacctcaag gccgccgccg tccgcgagac ctgcgacgtc gtcatcagca
     1141 acgtcctgct gatcgacgcc gtccagggca tccgcaaggt ctccgtcggc atccgcgagg
     1201 gccggatcca cgccatcggc cgggccggca accccgacac cctcgacggc gtcgacgtcg
     1261 tcgtcggcac cggcacctcg atcgtctccg gcgaggggct catcgccacc gcaggcgccg
     1321 tcgacaccca cgtccacctg ctctcgccgc ggatcatgga ggcctcgctc gcctccggcg
     1381 tcaccacgat catcggccag gagttcgggc ccgtctgggg cgtcggcgtc aactcgccct
     1441 gggcgctcca ccacgccttc aacgccttcg acgcctggcc cgtcaacatc ggcttcctcg
     1501 cccggggttc ctcctcggac ccggcgccgc tggtcgaggc gctcgcagag ggcggcgcct
     1561 ccggcttcaa ggtccacgag gacatgggcg cccacacccg cgccctcgac accgcgctgc
     1621 gggtcgccga ggagcacgac gtccaggtcg ccctgcacag cgacggcctg aacgagtgcc
     1681 tgtccgtgga ggacaccctc gccgtcctgg aaggccgtac gatccacgcc ttccacatcg
     1741 agggctgcgg cggcggacac gtccccaacg tcctgaagat ggcgggcgtg ccgaacgtca
     1801 tcggctcctc caccaacccc accctgccct tcggccgcga cgcggtggcc gagcactacg
     1861 ggatgatcgt ctccgtccac gacctgaaga ccgacctccc cggcgacgcc gccatggcgc
     1921 gcgaccggat ccgggccggg acgatgggcg cggaggacgt cctgcacgac ctcggcgcga
     1981 tcgggatcac ctcctccgac gcgcagggga tgggaagggc cggcgagacc gtacgccgga
     2041 ccttcgccat ggccgggaag atgaaggccg agctcggccc gctggagggc gacggcgcgc
     2101 acgacgacaa cgcgcgcgtg ctccgctacc tggccaagct caccatcaac ccggcgatcg
     2161 cccacggcct cgcccacgag atcggctccg tcgaggtcgg caagctcgcc gacatcgtgc
     2221 tgtggcggcc cgagttcttc ggcgccaaac cccagatggt gctcaaggcc ggcttccccg
     2281 cctggggcgt cacgggcgat cccaacgccg ccaccgacac ctgcgaaccc ctcgtcctcg
     2341 gcccgctgtt cggcgcccac ggcgccgccg ccgcggacct ctccgtcgcc ttcgtcgccc
     2401 aggccgccgt cgacctcggc ggcgaccgga tgccgacccg gcgccgccgc gtcccggtgc
     2461 gcggcacccg ggggatcggc cccgccgacc tgctcctcaa ctcccgtacc ggctccgtcc
     2521 aggtggacga ccgcaccggc ctcgtctcgc tcgacggctc cccgatccgc tccgagccgg
     2581 ccgactccgt ctccctgaac cgcctctact tcctctagga cccgccgaga tgacttcgta
     2641 ccgcatgccc gccgagtgga ccccgcacga gcggacctgg atggcctggc ccagccccaa
     2701 ccccaccttc accagcgacg aggagctcgc ggaggcccgc ggggcctggg ccgccgtcgc
     2761 ccgcgccgtc cgccgcttcg agccggtgac gatggtcgtc gcccccggcg acgccgaggg
     2821 cgcccgggaa ctcctcggcg aggacgtcga gctggtcgag cgggagctcg acgacgcctg
     2881 gatgcgcgac atcggcccca ccttcgtgaa ggacgcggag ggccggctgg ccgccgtcga
     2941 ctgggtgttc aacggctggg gcgcccagga ctgggcccgc tgggagcacg actccaagat
     3001 cgcccgccat gtcgcggacg cggccgaggt gcccgtactg agcagcgagc tggtcaacga
     3061 gggcggcggc atccacgtcg acggcgaggg caccgtcctg ctcaccgaca ccgtccagct
     3121 cggctccggc cgcaaccccg agtggagccg cgagcaggtc gagcgggaga tccacgccaa
     3181 gctcggcacc acccgggcga tctggctccc gcacggcctc gccggcgact acggcctcta
     3241 cggcacccag ggccacatcg acatcgtcgc cgccttcgcc cgccccggca ccgtcctcgt
     3301 ccacagccag caggaccccc gccaccccga ctacggccgc tcccggctgt acgcggacat
     3361 cctccgcgcc cagaccgacg cccagggccg ccccctggag gtcatcgagg tccccgcccc
     3421 caccgtcctc accgacgagg agggcgactg ggtcgactac tcctacatca accactacct
     3481 ctgcaacggc gccgtgatcc tctgcgcctt cgacgacccc cacgacgagc tcgccgccga
     3541 gatcttccgc cgcctcttcc cggaccgcga ggtcgtcctc gtcgacgccc ggacgatctt
     3601 cgcgtcgggc ggcggcatcc actgcatcac ccagcagcaa cccgcggtgt aggtgccacg
     3661 gcgccgatca gggccggtgg ggcctgccgc gggctcagac cgcgtcgccg tctcgccagt
     3721 cgaagacgag cggggcggtc gggtcgggca gggcgagtcc gccggccggg cggacgaaga
     3781 cgccgccctc ctcctcgggg agcgggacgg tgccgtcggg gccgagcacc tcgatccgcc
     3841 cgccccacac ctcccagccg cgcgcgcggt agagcgccgc gccctcgtcg gaggcggaga
     3901 gcgcgccgaa gcggtgggtg ccgtcgatca cccgctccag ggcgtccatg acggccccgc
     3961 cgaacccccg gcgccgcgcg tcggcccgga cggcgacgcc ttccacgtac ccggtccggt
     4021 acgagcggcc gcggtgcagc acccggcgct ggacgacggc cccgtgggcg aggagcccgg
     4081 tcgcgtcctc gatccaggcg tggaccccgc ccagggtgtg gtcccagtcc tccgcggaga
     4141 agtcgccgtc gaaggcagcg tcgagcagcg cgcggacggc cgtgagccgc tccgcgccga
     4201 gttcgtgggt gggtgcggtc ctcacggtca tcccctcacc ctcccacagc aacccccacc
     4261 cctcacctaa cccccttagt gcccttgacg ggttaagtag cccctgatcg aatcccctta
     4321 accgcttctt gagagttgag gggttagaga ccatgtccgt gctgcccacc cgccaccgca
     4381 ccgtcaccgt ccgcggccac gagatcttct accgggaggc cggaccggcc gacgcccccg
     4441 tcctgctcct gctgcacggc ttcccgacca gctcgcacat gttccgcgac ctgatccccc
     4501 gcctcgccga ccggtaccgg ctgatcgccc cggaccacct gggcttcggc cgcagtgccg
     4561 cgccctccgc cgacgccttc gcctactcct tcgcggaact ggccgcgctc accggcgagt
     4621 tcaccgaggc gctcggcctc gaccgcttcg cgatctacat ccaggactac ggcgccccca
     4681 tcggcctgcg cctcgccctc gcccaccccg agcggatcac cgcggtcgtc acccagaacg
     4741 gcaacgcgta cgaggagggc ctgggcacgg aggcctgggc ccccgtcctc gccctgatcg
     4801 ccgaccggac ccccgagacc gaggccccgg tccgggccat ccgctccctc gacggcatcc
     4861 ggtggcagta cgagacgggc gtccccgccg cctaccggga ccgcctcagc ccggacgcct
     4921 ggcaccacga cgccgccctg atggcccgcg agggccagga cggcatccag ctcggcctga
     4981 tcgccgacta cggctccaac ttcgccctct atccggcctt ccaggagtgg ttccgcacct
     5041 cccgggtgcc gctcctcgcc gtctggggcg agggcgacga ggtcttcgtc ccggccggcg
     5101 ccgaggcctt ccgccgcgac ctcccggacg ccgagatcca cctcctgccc accggccact
     5161 tcgccctgga gacgcacgcg ccgcgcgtcg ccgagctgat cggggacttc ctggagcggc
     5221 acgtgacggc gtaggcggga aatgaatacc gcccccgtcc ccggcctggg gggaccggag
     5281 aggggggcgg tgatcagggg ccgctcacgc ggcgggcggg gctcagccca tgtgcgggta
     5341 gccgtactcg gtcggcggga ccagcgtctc cttgatggcg cgggtcagcg tccagcgcat
     5401 caggttctgc ggggcgccgg ccttgtcgtt cgtgcccgag gcgcggccgc cgccgaaggg
     5461 ctgctggccg acgacggcgc cggtcgactt gtcgttgatg tagaagttgc ccgcggcgaa
     5521 gcggagcttc tccatcgtgt gcgcggcggc ggcgcggtcg ttggagatga cggcgccggt
     5581 cagggcgtag tcggagaccg actccatctg ctccagcatg gcgtcgtact ggtcgtcctc
     5641 gtagacgtgg atcgccagga tcgggccgaa gtactcggcc ttgaagacct cgttctccgg
     5701 gtcggtgcag gcgatgacgg tcgggcggac gaagtagccc tccgagtcgt cgtaggtgcc
     5761 gccggcgatg atcgtgcagc tcgggtcgga ggaggcacgg tcgatcgccg ccttgttctt
     5821 ggcgaacgag cggtcgtcga tgacggcacc gatgaagttc gacaggtcgg tgacgtcacc
     5881 catggcgatg ccgtcgacct cggccgcgaa ctcctccttg aagccgtcgt tccagatgga
     5941 cgccgggatg tacgcccgcg aggacgcgga gcacttctgg ccctggaact cgaaggagcc
     6001 gcgggtcagc gcggtcttca ggacggcgcg gtcggcgctg gggtgggcga cgacgaagtc
     6061 cttgccgccg gtctcgccga cgatccgcgg gtaggagcgg tacttctcga tgttggtgcc
     6121 gaccgtcttc cacaggtgct ggaaggtctt ggtcgagccg gtgaagtgga tgccggccag
     6181 gtcgcggtgg ttcagggcca cctcggagac ggcgatgccg tcgccggtca ccaggttgat
     6241 gacgcccttc ggcaggccgg cctcctccag gagctccatg aggagcacgg cggagtgggt
     6301 ctgcgtcggg gacggcttcc agacgaccac gttgcccatg agggcggggg cggtgggcag
     6361 gttgcccgcg atggccgtga agttgaacgg cgtgatcgcg tagacgaagc cttcgagcgg
     6421 gcggtggtcc agacggttcc agacgcccgg ggagttcgcc ggcggctgct cggcgaggat
     6481 ctggcgggcg tacgccacgt tgaagcgcca gaagtcgacg agctcgcacg gggtgtcgat
     6541 ctcggcctgc tgggcggtct tcgactggcc gagcatcgtg gaggcggcca gcgtctcgcg
     6601 ccaggggccg gcgagcagct cggcggcgcg caggatgatc gcggcgcggt cgtcgaagga
     6661 catcgcgcgc caggccgggg cggcggccag ggccgcgtcg atcgcgtcct gggcgtcctg
     6721 ctgggtggcg ccggcgaagg tgccgatgac ggacttgtgg ttgtgcggct gcacgacgtc
     6781 gacgcgctcg ccgccgccca tgcgcttcac gccgccgatg gtcatcggca gctcgcgcgg
     6841 gttgtcggcc agctccttga gcttggcctc cagacgggcg cgctccgggg aaccgggggc
     6901 gtaaccgtgc accggctcgt tgacgggagc ggggacctgg gtcacagcgt ccatgagggt
     6961 cttgactcct tcaaagaggg gtagtgggct cagcccttgg tcaggatgga gcggacgaag
     7021 aagagcaggt tggccggctt ctccgcgaga cggcgcatga agtagccgta ccagtcggtg
     7081 ccgtaggccg tgtagacgcg catgcggtgg ccctcggcgg cgagccggtt ctgctcctcg
     7141 gagcggatgc cgtacagcat ctggaactcg tactcgtcca gcttgcgccc ggcgcggcgg
     7201 gccagctcct ggccgatggc gatcaggcgc gggtcgtgcg agccgatcat cgggtagccc
     7261 tcgccgtcca tcaggatctt catgatccgg acgtacgcct tgtcgatctc gggcttgtcc
     7321 tggatggcga cctcggcggg ctccttgtag gcgcccttca cgatgcgcac gcgggagccg
     7381 ttcgcggcca ggcggcgggc gtcctcctcg gtgcggaaga ggtaggcctg gatgacgcag
     7441 ccggtctgcg ggaagtcctt ccgcagctcc tcgtggatgg cgaacatcga gtcgagggtg
     7501 gtgtggtcct cggcgtccag ggtgaccgtg gtgccgatct cggcggcggc cgcgacgacg
     7561 ggccggacgt tcgcgagggc cagctcgtgg cccttctcca gcgactggcc gaacatcgac
     7621 agcttgacgg acatctcggc gcgctcgccg aggcccagct ccttgaggcg gccgatcagc
     7681 tccaggtagg cgtcccgggc ggcgtaggac tgctcgacgg tggtgatgtc ctcgccgacg
     7741 acgtcgaggg tgacctccag gccgcgggcg gtcaggtccc ggacgatcgg gacgacgtcg
     7801 tccacgatct cgccggcgat gaagcgcgcc acgacctgct tggtcccggg cgcggccgac
     7861 acgagacggc gcatcttgtc gctgcgcgag gcggcgagga tcacgggacc cagcacgggg
     7921 cacctccaaa ggggcgagga agaacagggc cattaccggt cgcgggggta cgaaccggga
     7981 acagcacggg taaccaccgt gaaacctaag gatcgctccg atcctgcgcc atctacagct
     8041 gtcacgcatc cgtgaacacg ccctcagaca actgtctgaa gcaaccggtc ggcggtgcga
     8101 gaatgggccc cgtgaagggc gattaccagg agctggtgga cgagatctcg acgctgctcg
     8161 gcaccccggc gaccctggag aaccgcgatt tcgggctgat cgccttcggc gcccacgaca
     8221 gcgacgacga cagcgcgatg gacccggtgc gcacccgctc gatcctgacc cgcaagtcca
     8281 ccccggcggt ccgcgcctgg ttcgagggct tcggcatcac ccgcgccacc ggccccgtcc
     8341 gcatcccggc cgcgccggac gcgggcgtct accgggaccg gatctgcctc ccggtacgcc
     8401 atcggggtgt cgtcctcggc tacgtctggc tcctggacgc cgaacccggc ccctcgcacg
     8461 agcggctcac cgccgcgatg gaggtcgccg cgaggatcgg cgagctcctc gccgacgagg
     8521 agcgggcggg cgccgacctc tcccgcgagc tgcgggccgt cctcacggcg gagcgcggct
     8581 ggcagtacga catggccgtc gccgccctcc gcacggccct gggcccggac gcggacggcc
     8641 tccacgccct ggtctgcgtg gccccctgga ccggcgagga ctccccctcc ccccgtacgg
     8701 tccccggcgc ggccgtcgtc tgcgccctcc cgtggcgggg cccgggcggc ccctacgccg
     8761 gcgcccccgg ccgcgactcc gaggcggggg cctcccgggg cgaagcggtc cacggacccg
     8821 gcccggcccg gggggcccgc gccgcgtccg gcggtacggg ctccgcccgc ggcaccgcgc
     8881 ccggacacgg accctcctcc ggagctccgt ccgacggggg gtacgccccc gggcccgggc
     8941 cgcagcgggc cctcgccgtg ctggtgcggc tgcgctcggg cgacaacctc tcccccgcga
     9001 ccaccgccgc cgggcggctg cggggcacgg ccgggcaggc cgccgtcgcc gggatcgccg
     9061 cgccccggcg gggcctcggc gagctggacc tctcctggcg cgaggcctcg gccgccgccc
     9121 gcaccgcgca ctcccagccc cggctcggcc cgctcgccca ctggtcggag ctcggcgcgt
     9181 accggctgct caccgccctc ccgcaggccg agcccgaccc ggccgtacgg gcgctgctcg
     9241 cccccgcgca cacggaactg gcccgcacgg ccgaggtgtt cctcgaccac gcgggccagg
     9301 cgggccgcac ggcggcggcc ctgggcatcc accggcagac gctctactac cgcctctccc
     9361 gggtcgaaca gctcaccgga ctcgacctgg actccggcga ggaccgcctc ctgctgcaca
     9421 tggcgctgaa ggcggcccgg ctgtagcggg cggccttcac tccgcccggg ggacggtggc
     9481 cggaccgggc gccggctcgg gcgccggacc ggtgtcgggg gcggtggccg gccggggcac
     9541 acccgcggcg gcagccccgt cctcgtccgc gtcctcggtc tcgtccgctc ccccgccctc
     9601 ggggccgtcc aggccccgca tcgccggtac gacgaggagg agcaccgaga ccgcgcacca
     9661 ggcgatgccg agcgccacgc ccgtctcgcg gagcccggcc cgttcgacga cgagtccggc
     9721 gaggagggtg ctcaccggga cggccgtcat ggagacggcg ttctggagcc cgaggaccct
     9781 gccccgcacc tcctccggga cgcgctcgcc gacgaggacg aggaagagcg cgggcagcgg
     9841 tcccgccccg acgccggcca gcaccgcgca ggcgacgagc accggcaccg gcggcagcag
     9901 ggcgagcccg gccacgccga cggtcgacac gagctgggag accgcttctc tccgtacctg
     9961 tccccccggc gacgcgctgc gccgggtcct cggggcccgg gtggggctgt ggcgggccca
    10021 gtaccggcgt gcctcgttca cgtaccggct gggcttcgac tccgtcaccc tgaccgaccg
    10081 gcgccccggg ctccccgccg aggacaccgt cctcaccggc gacgacgccc gcctctaccg
    10141 cgccgtcatc ggcggggcgc gccaccgtga cctgaccggc ggggacccgg agcgggtacg
    10201 ggccaccctg gccggctggg agcgcaggcg gtgggtccac agcgagggga cgaaggtgat
    10261 cgcgctggcc acccgggcga cgccgtccgc ctaccgcacc ccgccgccga agggcacccc
    10321 ccggcgggcc cgcacccccg tccccctcac gctcaccacc cggccctgac cgagccgtac
    10381 gggatctggc cgaaaccgcg cgcatgccgc cgaacgccgt ttcccgacgg gcccgccgca
    10441 cggtagtcct gggggcacgg ggccgccgtc cccgacccgc cgcgcccgga ccgccgcccc
    10501 ggcggacccg gcgcccgcac gagaatccga gggcagagag ttgaccagcg agtacacccc
    10561 cggcaccgcc gccccgaccg cccccgcccc ggagggcgga ccggagggcg gaccgcaggg
    10621 cggtgagcgt ccgccgtcct gccgcgacct ggtcggactg ctcgcccagg acgaccggcg
    10681 gtcggcctac gcggccctgg tcctcggcgc caccagcctg ccgcaggtcg ccgagcgcac
    10741 cgggctccgc ccggcggcag cggcgatggc cctgcagaag ctggtggagg gccggatcgc
    10801 ctgccacgac cccgagggcg gctacacgct gctcgacgac accttccggc tcgcggtgcg
    10861 cgaggaggtg cggctgaccg gccggggcgg cggggacggc gcgggcgcct acttccgcaa
    10921 gggccggctg acctcgatcc ccggcaaggc ggaggtgcgc cgacgggtgc tcaccgtggt
    10981 cgccgactcc ttcgagaagg gcaccgtcta cgaggagtcc aaggtgaacg ccgtctgcgg
    11041 cggctggctc gacgactggg tctcgctgcg gcgcgccctg gtcgacgagg ggctgctgct
    11101 gcgggacgac gccacggcgc gctaccagcg ggcctgagcg ggcgccggag gtgaccctga
    11161 tccgcgccgg cgccgtggac gagccggccg acgtggtggc cctgccccgg cacacggccg
    11221 ccgaggccgg cgcgttcgcc cgccgccggg gcttcctcgg ccgggtcggg caggtggtgg
    11281 ccgagccctc ggcggacggg cggggcgtcc tgctgcacgt ggggctcggc ccggcggcca
    11341 ccgccgacgt cgccgccctc cggcaggcgg ccgcggccgc cgtccgggcc gccgggccgg
    11401 ccaggaccgt ccgcctcgac ctggcgctca ccgagcggac cggggtgacg gccgccgacc
    11461 gggtcgccgc cgtcacggag ggcgcccggc tcgcgctgta ccgcttcgac ggcttccgta
    11521 ccggccgcgg gcagcccccg cccgccgagc tcagggtgac gggcgaccgg cctgccgcgc
    11581 tcgcggcggc gctggccgcg gccgagggca cctgtctcgc ccgggacctg gtcaactccc
    11641 cgcccggggc gctgaccccg gccgcgttcg cccgccggat cgagaccgag gccgcggcgg
    11701 ccgggctgtc ctgcgcggtg tacgagggtc aggacctggc ccggctggac ctcgccggcc
    11761 tgacggcggt gagcaggggc tccgccgagc ccgcgcggta cgtggagctg gtgtacgagc
    11821 cgaccgggcc ggccgcgctc accgtggccc tggtcggcaa gggcgtcacc ttcgactccg
    11881 gcggcctgtc cctcaagccc tccggcgagc tgcacacgat gaaggccgac atggccgggg
    11941 ccgccgccgt cctgggcgcc ctggtggcgc tgccccggct cggcctgccg gtccgggtgc
    12001 gggcgcatct gccgctggcg gagaacatgc cggacggcgg ggcgctgcgg gtgggcgacg
    12061 tggtgcggca cctcgacggc acgaccaccg agatcaccca tacggacaac gaggggcggg
    12121 tggtgctcgc ggacgtcctg ctgcgggcga gcgcgcccgg cgccgccgat gtcgtcctcg
    12181 acgtggccac gctgacctcg gccgcggtgc acgcgctcgg cacccgtacc ggcgcggtct
    12241 tctcccccga cgacgggctc gcggagctgg tgcggagggc gggcgagcgg gccggggagt
    12301 cgctgtggcg gctgccgctc cttgcccacg agcggcggcg gctgcgctcg gcggtcgccg
    12361 accgggtcaa ctgctcgcac cggcacgggg acaccgtgca ggcggcgctg tacctctccg
    12421 agttcctcgc cccgggcacc cggtgggccc atctggacat cgcggcgccg gcctggaacg
    12481 acgagccgcc ttacggggag gtcccgcacg gcgcgacggg cttcggggtc cgcaccctgc
    12541 tggagacgct gcgggcgctg accgccggtg ccgccgaccc ggccggctac tgagccggcc
    12601 gggtcggggt gggatctgtg acgcggtgcg tcagatcagg ttgaccgagc gggccgaggt
    12661 ggcgccgatc tccgtggaga tctcggcgat cacggccgcg gggacggtgt cgtcgacggt
    12721 gaggacgacg agcgcctcgc cgccctcctc cgtacgggag acctgcatgc ccgcgatgtt
    12781 cagaccggcc tcgccgagga tccggccgac ggtgccgacg acgccggggc ggtcctcgta
    12841 gcggagcacg accatgtggt cggcgagcgc caggtccacg tcgtagccgc cgacggcgac
    12901 gatcttctgg aggtgcttgg ggccggccag ggtgccggag accgagacct cctcgccgct
    12961 ggagagggtg ccgcgcacgg tgaccatgtt gcggtggtcg ggcgactcgg agctggtggt
    13021 gaggcggacc tcgacaccgc gctcctgcgc gaagagcggg gcgttgacgt acgacacggt
    13081 ctcgtcgacg acgtcctcga acacgccctt gagcgcggag agttcgagca ccttgacgtc
    13141 gtgctgggtg atctcgccgt acacctcgac gtcgaggcgg gccgcgacct cgcccgcgag
    13201 ggcggtgaag atccggccga gcttctcggc gagcggcagg cccggcttga cgtcctcggc
    13261 gatgacgccg ccctggacgt tgaccgcgtc cggcaccagc tcgccggcga gcgcgaggcg
    13321 caccgaccgg gcgacggcga tgccggcctt ctcctgggcc tcgtcggtgg aggcgccgag
    13381 gtgcggggtg cagacgacct ggtcgagctc gaagagcggg gagtccgtgc agggctcctt
    13441 ggcgtacacg tcgaggccgg cgccggcgac gcggccctcc ttgagggccg agtacagcgc
    13501 ggcctcgtcg acgatcccgc cgcgggcggc gttgacgatg cggacgctcg gcttgacctt
    13561 gtgcagcgcc tcgtcgccga tgagaccgag ggtctcgggg gtcttcggca ggtggacggt
    13621 gatgaagtcg gcgacctcca ggagctcgtc cagggtcagc agcttcaccc ccatctgggc
    13681 ggcgcgggcc ggctgcacgt aggggtcgta cgcgacgacc ttcatgccga aggcggacat
    13741 gcgctgggcg accaggacgc cgatgcggcc gaggccgacg acgccgaggg tcttctcgct
    13801 gagctcgacg cccgtgtact tgttccgctt ccactcgccg ttcttcagcg cggtgttggc
    13861 ctgcgggatg ttgcgcgcgg tggcgacgag gaggccgcag gcgagctcgg cggcggtgac
    13921 gatgttggag gtcggcgcgt tcacgaccat cacgccggcc ttggtggcgg cggagacgtc
    13981 cacgttgtcc aggccgacgc cggcgcgggc gacgacccgc agcttcttgg cggcggcgat
    14041 ggcctccgcg tcgaccttgg tcgccgagcg gatgaggatg gcgtcgacgt cggcgatcgc
    14101 ggggatcagc tcggcgcggt cggcgccgtt gcagtgccgg atctcgaagt ccggccccag
    14161 ggcgtcgacg gtggcgggcg acagctcttc agcgatgagt acgacaggtt tcgagctcac
    14221 gtgagtcctc acagaggcag tgcggacggc cgtcccgacg gccgcaggcg gtggaggggg
    14281 cttgccgcgt ggaagcgcac gacgctgtgg gccagacgcg atgttgtttg agcagtgtag
    14341 tgccgcatcg gcgcacgtcg tacgcctcgt tggaaggatc acccgtccgt ggttggacgg
    14401 ggtgtccaag gatgcggcgc ggggccggac gacgtgtccg gccccgcgcc gaggggctta
    14461 cgcctcctcg tcgttcaccc agctcatgag cttgcgcagc tccttgccgg tggtctccag
    14521 gaggtgcttc tcgtcctggg tcttgtactc gtcgtacttc ttcaggccgc cgtggtactc
    14581 gtccatccag ttcttggcga aggtgccgtc ctggatctcg gtgaggacct tcttcatctc
    14641 ggccttggtg tcggcggtga tgacgcgcgg gccggtgatg tagtcgcccc actcggcggt
    14701 ctcggagacg gaccagcgca tcttctccag gccgccctcg tacatgaggt cgacgatcag
    14761 cttcagctcg tggaggcact cgaagtaggc gatctccggc tggtagccgg cctcgaccag
    14821 ggtctcgaag cccgccttga cgagcgcgga ggcgccaccg cagaggacgg cctgctcgcc
    14881 gaagaggtcg gtctcggtct cctcggtgaa ggtggtcttg atgacgccgg cgcgggtgcc
    14941 gccgatcgcc ttcgcgtacg acagggccag ggcgaacgcg ttgccggtgg cgtcctgctc
    15001 gacggcggcg atcgcgggga cgccgcgacc ctcctcgtac tggcggcgca ccaggtggcc
    15061 cgggcccttc ggggcgacca gggcgacgtc gacgccggcc gggggcttga tgaagccgaa
    15121 gcggacgttg aagccgtggg cgaagaacag cgcgtcgccg tccttcaggt tcggggcgat
    15181 ggactcctcg tagaccttgg cctggatcgg gtccgggatc aggatcatga tgaggtcggc
    15241 ctcggccgcc gcctcggcgg gggtgaccac gcgcaggccc tgctcctccg ccttggcctt
    15301 ggacttcgag ccctcgtgca gaccgacgcg gacgtcgaca cccgagtcgc ggagcgacag
    15361 cgcgtgggcg tggccctggc tgccgtaacc gatcaccgcg accttgcggc cctggatgat
    15421 cgagaggtcg gcgtcggcgt cgtagaacag ctcggccact gggattctcc ttggtgtgct
    15481 gatgttgcgt cccaccgtac ggcgggtggt ggacaggaag tcttctggtc tcgtcaggcg
    15541 gaacggtcga gcgcccgcag ggaccggtcc gtgatggacc gggcgccgcg ccctatggcg
    15601 atggtgcccg actggacgag ctccttgacg ccgaactgct ccagcatctt gagcatggcg
    15661 tccagcttgt cgcccgaacc ggtggcctcg atggtgacgg cctcgggcga gacgtcgacg
    15721 gtcttggcgc ggaagagctt gacgatctcg acgatctggg agcgggtctc gttgtcggcg
    15781 cggaccttca ccaggacgag ctcgcgctgg atcgcggcgc tgggctcgag ttcgacgatc
    15841 ttcaggacgt tgaccagctt gttgagctgc ttggtcacct gctccagggg caggtcctcg
    15901 acgttgacca cgatggtgat gcggctgatg tcggggtgct cggtgacgcc gacggcgagg
    15961 gagtcgatgt tgaagccgcg gcgggagaac agggcggcga tccgggcgag gatgccgggc
    16021 gtgttctcga ccaggacgga gagcgtgtgc ttggacatgg tgtgtgggtc tcttccctgt
    16081 ggctcgtcgc tgctcagtcg tcttcgccgt cgccgaagtc ggggcggacg ccccgggcgg
    16141 ccatgacctc gtcgttggag gtgccggcgg cgaccatcgg ccagacctgg gcgtcctcgt
    16201 ggacgatgaa gtcgatgacg accggccggt cgttgatggc gttggcctcg gcgatgacct
    16261 tgtcgaggtc ctccggggac tcgcagcgca tcgccacgca gcccatggcc tcggagagct
    16321 tcacgaagtc cgggacgcgg gtgcccttgg cctccgggtt gacgtcgtcc gggccggagt
    16381 gcaggacggt gttggagtag cgctggttgt agaagagggt ctgccactgg cggaccatcc
    16441 cgagggcgcc gttgttgatg atggcgacct tgatcgggat gttgttcagg gcgcaggtgg
    16501 cgagctcctg attggtcatc tggaagcagc cgtcgccgtc gatcgcccag accgtgcggt
    16561 cgggcatgcc ggccttggcg cccatggcgg ccgggacggc gtagcccatg gtcccggcgc
    16621 cgccggagtt cagccaggtg gcgggcttct cgtagtcgat gaagtgggcg gcccacatct
    16681 ggtgctggcc gacgccggcc gtgaagaccg tgccctccgg ggcgagctgt ccgatgcgct
    16741 ggatgacctg ctgcggcgag aggctgccgt cctccggcag gtcgtagccg agcgggtagg
    16801 tctcgcgcca gcggttcagg tcggaccacc aggcggtgta gtcgcccttc ctgccttcgg
    16861 tgtgctcggc ctggacggcc tggaccaggt cggcgatgac ctcgcgggcg tccccgacga
    16921 tcggcacgtc ggcggcgcgg ttcttgccga tctcggccgg gtcgatgtcc gcgtggacga
    16981 tcttggcgta cggggcgaag ctgtccagct tgccggtgac gcggtcgtcg aagcgggcgc
    17041 cgagggcgac gatcaggtcg gccttctgga gcgcggtgac ggcggtgacg gcaccgtgca
    17101 tgccgggcat gccgacgtgc tgcgggtggc tgtcggggaa ggcgccgagg gccatcaggg
    17161 tggtggtgac cggggcgccg gtcagctcgg ccaggacctt cagctcggcc gtggcgccgg
    17221 acttgatgac accgccgccg acgtacagga ccgggcgctt cgcggcggag atcagcttcg
    17281 cggcctcgcg gatctgcttg gcgtgcggct tggtcaccgg gcggtagccg ggcaggtcgg
    17341 tctgcggcgg ccaggagaag gtggtcttcg cctggagggc gtccttggcg atgtcgacca
    17401 ggaccgggcc cgggcggccg gtggaggcga tgtggaaggc ctcggcgatg gtcttcgcga
    17461 tgtcctcggc cctggtgacc aggaagttgt gcttggtgat cggcatggtg atgccgacga
    17521 tgtccgcctc ctggaaggcg tcggtgccga tcgccttgga ggcgacctgc ccggtgatcg
    17581 cgaccagcgg gacggagtcc atgtgggcgt cggcgatggg ggtgacgagg ttggtggcgc
    17641 cgggaccgga ggtcgccatg cagacgccga ccttgccggt ggcctgggcg tagccggtgg
    17701 cggcgtggcc ggccccctgc tcgtggcgga ccaggacgtg gcggaccttc tcgctgtcca
    17761 tcatcgggtc gtacgccggg aggatgcagc cgcccggaat gccgaagacg gtgtccgcgc
    17821 ccacctcttc gagagagcgg atgagggact gcgcgcccgt gacgtgctcg acggtggggg
    17881 cgggcgtcgc gccgctgcgg ggccgcggct gcggatggtg cccggtggcc tgctcggtca
    17941 tcagcatctc ttctcgaagc agagggtttt tgcgggggtt ttgcggggtt tggcgtcgac
    18001 gtccgggaga accggtgcaa caaaaaaccc ctcgtgccag aaggcaagcg aggggagcgc
    18061 gtcgggtggt tctcagccgg ccttcagggg cccggcttca gccgacgcgc tttccaagta
    18121 cgagaattcg ggtgcgcatg gcactgaccc tccctcccgg gccacaccac tgtcaagtgg
    18181 gtgggacgca cgtctcatca tgtgaacggt tcgggggagg gattccgccg ctcctcggac
    18241 cccttgccgg ccggtacgga gacggctccg ggcagcggat agtcgccccg tacgagggcg
    18301 cgccgcagcc ggtactcgtc gagcgggccc gagaaggcca tgccctgcgc gtgccggcag
    18361 cccatggacc gcagggccag cacctgctcg gggacgtcga cgccctcggc gacggtctgc
    18421 aggcccagct cgccggcgat gcggagcacc ccacttgtga tcttgcggag ccgggcggat
    18481 tcgaccacgc cttcgacgag tgccctgtcc agcttcagta tgtcgaccgg gaggcgcctg
    18541 agggcgtgga cggcgacgtg tccgctgccg aatccgtcga gggcgacgcg gacgccgagc
    18601 cggcgcaggg cgaccaggcg ctgctccagc tcgtcgaggg gggtccgctc gtcggtgtcg
    18661 gccagctcga cgacgaggga gccggacggc agcccgtgcc gggcgagcag ggcctcgacg
    18721 gagccgaggg gcagggagcg gtcgagcagc cggcgggcgg agacccggac ggagaccggg
    18781 gtgcggtggc cggcgccggc ccgctcggcg gcctgctcga cggcctcctc caggacccag
    18841 cggccgagct cggcggtgcg ctcgccgtcg tcggtgacgc ggaggtactc ggcgggggtg
    18901 aagaggatgc cctgggcgga gcgccagcgg gcctgcgcgc tgacggcgga gacccggccg
    18961 gtggcgaggt ccacgacggg ctggtggagg agggcgaact cgccgtcgtg gagcgcgctg
    19021 cgcagccggg cggcgagctc ggtgcgccgg acgacctcgg cctgcatctg ggggacgtac
    19081 agctcgaccc ggtccttgcc gccggccttg gcccggtaca tggcgaggtc ggcgttgcgc
    19141 agcaggtcgc cggcgccgat gccgggctcg gcgaaggcga cgccgatgga ggcggcgacc
    19201 cggacctcgg tgccgccgtc gacccggtag gggcgggaga gggtgagccg gagccggtcg
    19261 gcgatctcct ggacctgggt ctggcgggcg gcgcggtcgt ggtgcccgtc gccgaggatg
    19321 agggcggcga actcgtcgcc gccgagccgg gcggcggtgt ccccggcgcg tacggcctcc
    19381 tggaggcggc gggcggcctg cacgaggagg tcgtccccgg cctggtggcc gagccggtcg
    19441 ttgaccgcct tgaagccgtc gaggtcgatg aagaggacgg cggtgccggg gtcggaggag
    19501 cggcggccgc cgagggcctg tccgacgcgt cgggtgaaga gcgcgcggtt gggcaggtcg
    19561 gtgagcgggt cgtgctcggc gttgtgctgc agctgggcct ggagccggac ccgttcggtg
    19621 acgtcgcggc tgttgaagat caggccgccc tggtggcggt tgacggtgga ctcgacgttg
    19681 agccactcgc cctctccctc tccctcggcc tcggcctcgg cctcaatctc ggtctcggcg
    19741 ggacggtggg cgcccgcggg gccggagcgg aagcggcact cgatgcgggt ggtgggctcc
    19801 tcggcgggcg aggcggcgag gaagcggcgg atctcgtgga cgacggcgcc gaggtcctcg
    19861 gggtggatga gcgcggccag ctcggagccg atgagctcct cggcgtcccg gccgtacacc
    19921 ccggcggcgg cggggctgac gtaccgcagg acgccgttgg gcgcggcgat catgatgacg
    19981 tcgctggagc tctgcacgag cgacctgaag tggttctcct tctgggccag ttcgtgggtg
    20041 agggcgatgt tgtcgatcag catgatgccc tggcggacga cgagggcgag gacgacggcg
    20101 cagccggtga ggacgacgac gcggtcgacc cggcgcccct cgacgacgtt gtacaggatg
    20161 ccgagggtgc acacggcggc ggcgaggtac ggggtgaggg cggcgagcga gccggcgatg
    20221 ggccggctgg cgggcaccgg ggcgcgggcc gccgtcgcct ccggcgggcg gtggaccccc
    20281 cagggggcgt aggcgagcag cagggagccg gcgaaccagc cggcgtcgag cagctggccc
    20341 gagacgtagt tggcgcgcag cagcggcga
//
