LOCUS       NZ_JABAOB010000011     20972 bp    DNA     linear   CON 23-OCT-2023
DEFINITION  Chitinophaga sp. Ak27 Ak27-scaffold_11_length_302033_cov_131.587,
            whole genome shotgun sequence.
ACCESSION   NZ_JABAOB010000011
VERSION     NZ_JABAOB010000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga sp. Ak27
  ORGANISM  Chitinophaga sp. Ak27
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1  (bases 1 to 302033)
  AUTHORS   Yin,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2020) State Key Laboratory of Plant Genomics,
            Institute of Microbiology, Chinese Academy of Sciences, Beichen west
            road, Bejing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-AUG-2019
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 246.8x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/23/2023 02:22:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,312
            CDSs (total)                      :: 6,224
            Genes (coding)                    :: 6,211
            CDSs (with protein)               :: 6,211
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4, 4 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 13
            CDSs (without protein)            :: 13
            Pseudo Genes (ambiguous residues) :: 0 of 13
            Pseudo Genes (frameshifted)       :: 0 of 13
            Pseudo Genes (incomplete)         :: 11 of 13
            Pseudo Genes (internal stop)      :: 2 of 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:12:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 105685
            Orig. end                         :: 126657
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABAOB010000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20972
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20972
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20972
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10972](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10972)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            459..1349
                     /locus_tag="HGH90_RS28320"
                     /old_locus_tag="HGH90_28320"
     CDS             459..1349
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791317.1"
                     /locus_tag="HGH90_RS28320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28320"
                     /product="DUF1338 domain-containing protein"
                     /protein_id="WP_168765316.1"
                     /transl_table=11
                     /translation="MLKDVLNGLMERYQQRVPDVAAVITAMIKEGMIRKADDIENDHIA
                     FRTMGVPQLGVASLEKIFLHYGYRKMDHYHFAAKKLDAWWYAPPAPQYPRIFISELRVK
                     DLSQQAQDIIYSYTREVSSDPVDQLNLDDSATVDTFLHSALWRTPTVADYNLLAAESEY
                     AAWVIYNRYYLNHFTVSVHNLPTGYNTVADFNTFLEKHGFRLNDAGGKIKTSPDGMLLQ
                     SATVARMITAEFAGGEKQDIAGSYVEFAERKILPAFVGLPAGEIRREHRREGFEAGNAD
                     KIFESTYAAQTKKTS"
     gene            1374..2903
                     /locus_tag="HGH90_RS28325"
                     /old_locus_tag="HGH90_28325"
     CDS             1374..2903
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791316.1"
                     /locus_tag="HGH90_RS28325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28325"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_169192462.1"
                     /sec_met_domain="Aldedh (E-value: 5.5e-140, bitscore:
                     460.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEDILKALGIQGEQSGVSTGAHWLPAHGATITSVSPVDDKKIAA
                     VKGANREDYDQVVAIAQEAFKEWRNWPAPKRGEIVRQIGEALRKHKEHLGKLVSYEMGK
                     SLQEGYGEVQEMIDICDFAVGLSRQLHGLTMHSERPGHRMYEQWHPLGITGIISAFNFP
                     VAVWSWNSMLAWVCGNVCIWKPSEKTPVTALACQRIVDTVFAANKVPEGVCNLVIGDRD
                     AGEWMSHDTRIPLVSATGSTRMGKAVGAAVGQRLGRSLLELGGNNAIIISQDADLDMSI
                     IGAVFGAVGTAGQRCTSTRRLIIHESVYDAFTARLVKAYSQLRIGNPLDQHNHVGPLID
                     KAAVNAYLDSIEQVKAQGGSFLVEGGVLSGAGYESGCYVKPCIAAVENTYAIVQHETFA
                     PILYVMKYKTLAEAIAMQNDVPQGLSSAIMTLNLREAEQFLSHAGSDCGIANVNIGTSG
                     AEIGGAFGGEKETGGGRESGSDAWKAYMRRQTNTINYSTSLPLAQGIKFDF"
     gene            complement(3355..3600)
                     /locus_tag="HGH90_RS28330"
                     /old_locus_tag="HGH90_28330"
     CDS             complement(3355..3600)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HGH90_RS28330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HGH90_28330"
                     /product="hypothetical protein"
                     /protein_id="WP_168765318.1"
                     /transl_table=11
                     /translation="METATQRAKVRMRQLDYFKLADNPEQAANVFNHLIKRNKGKAFVI
                     CSDPENITAVIYRTGLWGKEIKTLYDRGSGQVLTVK"
     gene            3793..5490
                     /locus_tag="HGH90_RS28335"
                     /old_locus_tag="HGH90_28335"
     CDS             3793..5490
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.3"
                     /locus_tag="HGH90_RS28335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28335"
                     /product="S8 family peptidase"
                     /protein_id="WP_211093026.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.9e-53, bitscore:
                     174.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLFSREVAALAGCIALMTAFTTSADAQSKVQVPKNWQLLSYDTD
                     SVFGTSTEKAYKELLKGKKSTPVIVAVIDSGIDTLHEDLKNILWTNPREIPGNGKDDDH
                     NGYIDDIHGWNFLGGKDGASLKEDSEEAAREYYRYKSLYGNPDSALAKDSKEYAIWQQL
                     QSKVEKPNSQFKVQYKSMSKLQENVNKCETILKNYLGKDDFNVAQLDSIQTTNQDVLLA
                     RNFMSRLLKSAGDEPATFGEFKMEFDEYMNELKRKAEATDVLPNANRERIVGDNLEDIN
                     DNKYGNQDVMGTFGFHGTHVSGIIAASRNNSVGIDGVADNVRIMAVKAVPDGDERDKDV
                     ALAIRYAVDNGAQIINMSFGKPFSPHKEWVDAAVKYAEEKGVLLVHAAGNDGANNDSVA
                     NYPNPNYLDGGRAANFITVGAISTGTMPDKVASFSNYGKKEVDLFAPGVQIYSTIPGGN
                     KYGSASGTSMASPVVAGVAALVLSYYPELSAKQLKYVLEKSATPLPDGSTMVNKPGSSD
                     EKIAFSDLSVTGGLVNAYEALKLAATIKGENVKGKKQHKAKVKPIKKN"
     gene            complement(5563..5973)
                     /locus_tag="HGH90_RS28340"
                     /old_locus_tag="HGH90_28340"
     CDS             complement(5563..5973)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021221.3"
                     /locus_tag="HGH90_RS28340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28340"
                     /product="DUF4870 domain-containing protein"
                     /protein_id="WP_168765319.1"
                     /transl_table=11
                     /translation="MNPKEERTWSTFIHLGGLIGMWIIPTVGNIIGALVLWLIKRNDSH
                     VVDDQGKEAVNFQITYSLAVIAAKIVENILYGIWSVATFWSRPWWNFSFTWGWGSLVQI
                     LWFLNVIFSIVAAVRANEGKIYRYPLSLRLVK"
     ncRNA           complement(6041..6418)
                     /db_xref="RFAM:RF00010"
                     /gene="rnpB"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00010"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /locus_tag="HGH90_RS28345"
                     /ncRNA_class="RNase_P_RNA"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="HGH90_28345"
                     /product="RNase P RNA component class A"
     gene            complement(6041..6418)
                     /gene="rnpB"
                     /locus_tag="HGH90_RS28345"
                     /old_locus_tag="HGH90_28345"
     gene            complement(6443..7492)
                     /locus_tag="HGH90_RS28350"
                     /old_locus_tag="HGH90_28350"
     CDS             complement(6443..7492)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013844.3"
                     /locus_tag="HGH90_RS28350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28350"
                     /product="Smr/MutS family protein"
                     /protein_id="WP_168765320.1"
                     /transl_table=11
                     /translation="MKYQIGDRILLLSSKEEGTVVELVNDNMVMIEIKGTSFPVYLDQI
                     DFPYFHRFTQQKLVKEKPRLIPGDEIKVDRSKYEVFKTDKGMFLSVLPVYQMDGLDETV
                     KLMKFHLFNDTPHAMRFYFQIWLNNQLDLEIKNEIQPYNHFYLADLLFESLNDNPRFEF
                     TFFLKEPQPKLATSVKKTWRIKAKQMFVQLEQLRTKAEATITYPLFDKFPEKEPEPEPT
                     PEQPKKKAPITSIGSGNFASLLSKIQLQPETTLTPKQEVDLHIEALEKNWKGLSNIAIL
                     AIQLNAFQRYLELAISHHQHNLVVIHGVGKGKLRDEIHQVLRQTPEVANFVNQYHAKYG
                     YGATEITFR"
     gene            complement(7560..8024)
                     /locus_tag="HGH90_RS28355"
                     /old_locus_tag="HGH90_28355"
     CDS             complement(7560..8024)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791310.1"
                     /locus_tag="HGH90_RS28355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28355"
                     /product="DoxX family protein"
                     /protein_id="WP_168765321.1"
                     /transl_table=11
                     /translation="MNMLQRVEHWGDTHSPNWLSAVRILLGVFLMGMGVLFVMDRDALV
                     SMISQRPTMAAMSIMLGHYIVFAHIVGGLFIAMGLVTRFSVIVNIPILLGAVFFVHSPT
                     KLFNVYPSTGLAILVLLLLIVFLVEGSGRISVDDYMRRHPEKRNHKYIDF"
     gene            complement(8182..9819)
                     /locus_tag="HGH90_RS28360"
                     /old_locus_tag="HGH90_28360"
     CDS             complement(8182..9819)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008583232.1"
                     /locus_tag="HGH90_RS28360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28360"
                     /product="amino acid permease"
                     /protein_id="WP_169192463.1"
                     /transl_table=11
                     /translation="MSNSLFRKKSLATILKDAKDGLADGHETGGMHKVLKVKDLTAMGI
                     AAVIGAGIFSTIGEASFHGGPGVSLLFVITAITCGFSALCYAEFASRVPVSGSAYTYSY
                     VTFGELAAWVIGWALILEYAIGNIAVAISWSGYFNNLLGGLGLSLPPWLASNYDSASPA
                     LIAAAPHIAGIPIILNLPAFIIVVIVTYLAYVGIQESKRSANFMVALKILVILFVIVVG
                     FFYVNKANWSPFMPNGFSGVMKGVSAVFFAYIGFDAVSTTAEECANPQRDLPKGMIYSL
                     IICTVLYVLISFVLTGMVPFYNLKVDDPLAFVFDQVHLPWISYLISVSAVVATTSVLLV
                     FQIGQPRIWMSMSRDGLLPRRFSTIHRRFKTPSYATIITGLLVGIPALFLNLTIVTDLT
                     SIGTLFAFILVCGGVLILPREEKATTKRFQLPYINGQWIVPALVVGLIILFNKEILLKL
                     SMEGGWNVWKHNIPFYLFVVVTLIITYLSATRKLSLIPVLGMLSCFYLMTEIALKNWIV
                     FSIWLAMGLVIYIGYSYSHSKLAVKQNA"
     gene            complement(10001..10972)
                     /locus_tag="HGH90_RS28365"
                     /old_locus_tag="HGH90_28365"
     CDS             complement(10001..10972)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791307.1"
                     /locus_tag="HGH90_RS28365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28365"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_169192464.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.6e-65, bitscore:
                     214.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQSFQDLIAQFSQHFNQQQFPAQPRKLYDAASHILGIGGKRIRPV
                     LCLMGNELFDTLRPDALEVGSAIELFHNFTLLHDDIMDKAPLRRGKPTVHTVYGDSAAI
                     LAGDVMLINVYERLNKVQAHYKQKIISVFNKAAIEVCEGQQLDMDFETMDPEAVQYDDY
                     VNMIGLKTSVLLAASLQLGAIIGGAGEGNQQHLYNFGKNVGIAFQIQDDYLDAFGDPEK
                     FGKQQGGDILVNKKTFLLLKAFELCNAAQKAELIRLMEASPANKVERVLELFRACKVDE
                     WAEKEKERFTRLAFQSLDHIAVLSSRKAPLMDLANYLLNRQQ"
     gene            complement(10993..14133)
                     /gene="rnr"
                     /locus_tag="HGH90_RS31690"
     CDS             complement(10993..14133)
                     /GO_function="GO:0008997 - ribonuclease R activity
                     [Evidence IEA]"
                     /GO_process="GO:0006401 - RNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rnr"
                     /inference="COORDINATES: protein motif:HMM:TIGR02063.1"
                     /locus_tag="HGH90_RS31690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonuclease R"
                     /protein_id="WP_211172698.1"
                     /transl_table=11
                     /translation="MSRKKKNKKGNHHHPPQNIQKKSFKGIVEVTKSGMAFVIVEGLTK
                     DIMVKQKNLHTALDRDEVLVDVLTQDRNNGARMEGIVTDILKRNKTEFTGTLQVSKSFG
                     FLIPEKGLFMPDIYIPANSLGTAKSGDKAVVKIVAWGEKSRKPVGEIIEILDATNTNDL
                     AMKEILIEAGFPLNFPKEVMAELDHLQENITETEVRNRKDIRKFLTMTIDPVDAKDFDD
                     AISLRLLKNGLYEVGVHIADVSHYVLPGTELDKEADKRATSVYLPDRVLPMLPEKISNE
                     LCSLRPHEDKLTFSAMFQMTDKGEIKQHWIGRTVIHSDHRFTYEEVQDIIETKEGLYRN
                     EVLLLNRIAQNLRAQRFEKGAINFSSQEVRFKLDETGKPVGIVVKESKEAHQLIEEFML
                     LANKTIAAFVAKLRINKQPIPFPYRVHDTPDPEKLKTFALFAGKFGYKFDLSGPETIAE
                     SFNNMLARVKGRPEQPVLETLGIRTMAKAIYTIDNIGHYGLGFEDYCHFTSPIRRYPDV
                     LVHRVLAECLANSVRPDKQMEQKCKHSSEMERKAMEAERAGNKYKQVEYMQQFIGHTFE
                     GVISGVAHFGFWVETMDTKCEGLISIHNLNRREDFQYNEGEYALVGQRTGRKFRIGEKV
                     SIRVVAANLAKRQLDYDLEDELTGTAVPAAPGAFQPKRRDDQRKEQRRDERKRKKEKFR
                     ADKQRKPWEHTPALKTHEAPRIEPEPVPVVDQVVAETHVVPVAPVAEPVTSAVSQPAAS
                     EKKAKKKKEQKPVTVTTAPAPVATPAPAKPATPAPVKEAAISKEEVKVPVKKATDKVAA
                     KPASKTSAKSAAEPAPAAKSPVKKGGAAPAGKAAVAKAPAKKPVVAKAPAKKATVKVPA
                     KPAKKAAVAKTPAKKATVKVPAKPAKKAAVAKTPAKKVVAKVAAKPAKKAAVTKAPAKK
                     AVAKVAAKPAKKAAVTKAPAKKAVAKGAAKPAKKAAVTKAPAKKAVAKVAAKPAKKAAV
                     TKAPAKKAVAKVAAKPAKKAAVTKAPAKKAVAKVAAKPAKKATAKPANKKTTKKKSK"
     gene            complement(14149..15219)
                     /gene="lpxK"
                     /locus_tag="HGH90_RS28380"
                     /old_locus_tag="HGH90_28380"
     CDS             complement(14149..15219)
                     /EC_number="2.7.1.130"
                     /GO_function="GO:0009029 - tetraacyldisaccharide 4'-kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009245 - lipid A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lpxK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791305.1"
                     /locus_tag="HGH90_RS28380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28380"
                     /product="tetraacyldisaccharide 4'-kinase"
                     /protein_id="WP_169192465.1"
                     /transl_table=11
                     /translation="MLRYLNFLLYPFSLLYGLVMWIRNRLYDKGLLTAVEFDLPVIAAG
                     NLSVGGTGKTPHVEYMIRLLKDHLNVATLSRGYNRRTSGYLLADEHSTAEDIGDEPMQF
                     HDKFPDIKVCVGEERMLAIPQLLGDEPNTQVILLDDAFQHRSIKPGMNIMITDYSRLFT
                     RDHVVPFGRLREGRAGYHRANCIIVSKCPPDMSLAEKAALEKEINPLPHQRLFFTTLQY
                     GALSDMVTHQPVEIPPSATVLLACGIARPEPLLNELKRRYDQVYLLSFPDHYYYTEKDI
                     AKIKKECSDLPGTEKIVITTEKDAVRLHLLKKELAEQNLRMAVIPVEVSFLFGEAELFN
                     NFIFDYISRHLPAPGQ"
     gene            complement(15226..15798)
                     /locus_tag="HGH90_RS28385"
                     /old_locus_tag="HGH90_28385"
     CDS             complement(15226..15798)
                     /EC_number="6.3.3.2"
                     /GO_function="GO:0030272 - 5-formyltetrahydrofolate
                     cyclo-ligase activity [Evidence IEA]"
                     /GO_process="GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02727.1"
                     /locus_tag="HGH90_RS28385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28385"
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="WP_169192466.1"
                     /transl_table=11
                     /translation="MTTKKDIRKHFLELRLNMDDNTALDLNGRLLNRCRQLDYGRFRMA
                     HVFLPISEKKEADTWPLVKWLRDEYPGLQWALSRSDMKTGDMIHYLWKTNTILIKNQFG
                     IPEPEHGEEVQPADIDLIFVPLLAFDRKGQRVGYGKGMYDRFLQQCPTAYTVGLSLFEP
                     VPAIQDVDPWDIPLQTVVTPDHIYQFK"
     gene            complement(15795..16439)
                     /gene="bioD"
                     /locus_tag="HGH90_RS28390"
                     /old_locus_tag="HGH90_28390"
     CDS             complement(15795..16439)
                     /EC_number="6.3.3.3"
                     /GO_function="GO:0004141 - dethiobiotin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009102 - biotin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bioD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791303.1"
                     /locus_tag="HGH90_RS28390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28390"
                     /product="dethiobiotin synthase"
                     /protein_id="WP_168765326.1"
                     /transl_table=11
                     /translation="MSERIFITGIGTGVGKTISAACVTEALQADYWKPVQTGLLEGTDT
                     DTVGSLLSNNVSVCHPEAWLLKAPASPHLAARLENKNIDINRIVALSKQYQPLDRALVM
                     EGAGGLLVPINETLSTLDLILALGAKVLVVAQNYLGSINHAMLTARVLQHTGVPVIGWV
                     FNGDYHTNEDDIVRWSGYPKIGRIPQANPVDKAFVQQQAQLLSASLHTLMA"
     gene            16550..17908
                     /locus_tag="HGH90_RS28395"
                     /old_locus_tag="HGH90_28395"
     CDS             16550..17908
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018629990.1"
                     /locus_tag="HGH90_RS28395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28395"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_168765327.1"
                     /sec_met_domain="PALP (E-value: 2e-67, bitscore: 221.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYCDNILETIGNTPMIRLHRVTATLPCTVLAKVEFFNPGNSIKD
                     RMAVKMVDVAEQKGLLKPGGTLIEGTSGNTGMGLALAAIVRGYKCIFTTTDKQSKEKVD
                     ILKAVGAEVIVCPTNVEPEDPRSYYSVSKRLATEVPNSFYVNQYDNLANRDAHYEQTGP
                     EIWEQTEGKITHLVVATGTGGTVTGTGKYLKEKNPDIQVWAIDSYGSLLKKYFETGEID
                     MNEVYPYITEGIGEDFVPENYDMTVIDKFEKVTDKDAAVMARRITKEEGIFVGYSAGSA
                     IQGLLQLKASLKPTDVVVVIFHDHGSRYVGKIYNDQWMMERGFLDVKTVKDVVNGRRNQ
                     PLVTIGTDEKVSEAIARMKKFDIEHIPVVKDSEIVGSISESGLFNRLIDDANLKDAAIQ
                     QVMQASFPLVGQDTPIEKLSVYINRENGAVLTKDDSGNYHIVTKYDIIQALGR"
     gene            17986..18771
                     /locus_tag="HGH90_RS28400"
                     /old_locus_tag="HGH90_28400"
     CDS             17986..18771
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014220694.1"
                     /locus_tag="HGH90_RS28400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28400"
                     /product="helical backbone metal receptor"
                     /protein_id="WP_169192467.1"
                     /transl_table=11
                     /translation="MLTFTDQLDRQITLAHPPQRIISLVPSQTELLWSLGLEKEVVGIT
                     KFCVRPSTWFREKTRVGGTKNIHPDIIRSLNPDLIIANKEENTAADVTALMEHYPVWVS
                     NIQTLDDAVEMISGIGAITGRQSAATDICTRIQAGFSALQPLAEPEPTAYFIWREPWMV
                     AGGDTFIHEMLRACGLQNVFGSRPRYPSVTAEELFHSGCRRVLLSSEPYPFKEKHIAEL
                     QTMLPEAQVQLVDGEMFSWYGSRLLESPAYFQSLLHPSI"
     gene            18835..19275
                     /locus_tag="HGH90_RS28405"
                     /old_locus_tag="HGH90_28405"
     CDS             18835..19275
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012575.3"
                     /locus_tag="HGH90_RS28405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28405"
                     /product="Rieske (2Fe-2S) protein"
                     /protein_id="WP_168765329.1"
                     /transl_table=11
                     /translation="MERRDFVSNLGLTLALACTAGLAACSKGGSNDNPTPTPPAGGNAK
                     LTLNLASDLPNVGDFKISNGVILIRTGSGNTASAFTALSSTCTHQGCTVATYNTSSKLI
                     ECNAPCGHGSRYTTTGAVNTGPATAALSAFTVKVDGNVLTVS"
     gene            complement(19272..20084)
                     /locus_tag="HGH90_RS28410"
                     /old_locus_tag="HGH90_28410"
     CDS             complement(19272..20084)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (48-148). E-value:
                     4.8e-17. Score: 54.3. Matches aSDomain:
                     nrpspksdomains_HGH90_RS28410_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.3"
                     /locus_tag="HGH90_RS28410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_28410"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_169192468.1"
                     /sec_met_domain="PF00561 (E-value: 4.9e-14, bitscore: 46.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.8e-11, bitscore:
                     38.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYLVLLLLLWLKMPVAQAFTSEVADSLLYYTSFDGTHIHYSVK
                     GSGKPVILIHGFIVDGESWKRTALYDSLLLHGFRVITLDMRGNGASGHPQDSTAYLHDA
                     EAKDVMELASQLGLQHYQVVGYSRGSIITARLLVLDNRISSAVIGGMGTAFTNPAWPRR
                     QQFYEALSGKPVPALAAMVKNVQKAGLDQRALAWMQFGQPTTTPQELAKVQQPVLVIGG
                     DKDEDNDTGGSLAAMMPAGMHGTVTGDHNSVVRSAAFAAWVLDFLQNH"
     aSDomain        complement(19641..19940)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HGH90_RS28410_Abhydrolase_1.1"
                     /evalue="4.80E-17"
                     /label="HGH90_RS28410_Abhydrolase_1.1"
                     /locus_tag="HGH90_RS28410"
                     /protein_end="148"
                     /protein_start="48"
                     /score="54.3"
                     /tool="antismash"
                     /translation="KPVILIHGFIVDGESWKRTALYDSLLLHGFRVITLDMRGNGASGH
                     PQDSTAYLHDAEAKDVMELASQLGLQHYQVVGYSRGSIITARLLVLDNRISSAVI"
ORIGIN
        1 ttatcctggt cactgtaacc tgatgaaaat tctgctcaac gagcttaaac tcaataaaaa
       61 gcgggaaatg ttgaaggaga ttatggaaga tagcatacct ttcaccccac aggacgtggt
      121 attggtattt gtatccgttt ccggcactgt aaatggccgt tcggtacagc gctcctactc
      181 ccgtaagatc tacaaccagg ctattgctgg taaggatttc acggctatcc aacttaccac
      241 cgccggtgcc gcctgtgcag tcatcgacct ccatgccaag ggcaaactgc cggcgaccgg
      301 ctttgttcgc caagaagatg tggcgttcgg agatctgatc aagaaccgct ttgcggtata
      361 ttataattag tttttaacta tctgctcttg gtaaattgcc gtaaggagtg gcctctttac
      421 cagaaatact aacagctaat tgcaaaaacg catcctcaat gttaaaagat gtattaaatg
      481 ggctgatgga acgctatcag cagcgggttc cggatgtggc ggcagtgatt accgccatga
      541 taaaagaagg aatgatccgg aaggcagatg atatcgaaaa cgatcatatt gcgttcagaa
      601 caatgggagt tcctcagctg ggggtagctt cgctggaaaa aatatttctg cactatggct
      661 accggaaaat ggatcactac cattttgccg ccaaaaaact ggatgcctgg tggtatgcgc
      721 cgcctgcgcc ccaatatccc cggatcttta tcagtgagct ccgggtaaag gatctcagcc
      781 agcaggcgca ggatattatt tatagctata cccgcgaggt gagcagcgac ccggtagatc
      841 aactgaacct ggatgatagc gccactgtgg atactttttt acacagcgcc ctgtggcgta
      901 cccctaccgt agcagattat aacctgctgg cggcagaaag tgagtatgca gcctgggtga
      961 tttataaccg ttattacctg aaccacttta ccgtgagcgt gcataacctg ccgactggat
     1021 acaatacggt agccgatttc aataccttcc tggagaaaca cggcttccgc ctgaacgatg
     1081 caggaggtaa aatcaaaacc agcccggatg gcatgttgtt acaaagcgcc actgtagccc
     1141 gtatgatcac tgccgaattt gctggcggcg aaaaacagga tatcgccggc tcctacgttg
     1201 aatttgccga aaggaagata ctcccggcat ttgtgggtct ccccgccgga gaaatccgcc
     1261 gcgagcaccg ccgggaaggc tttgaagccg gtaatgccga taagatcttc gaaagcacct
     1321 acgctgccca aacaaaaaaa acttcctaat ttcgttcaat aatacacctg acaatggttg
     1381 aagatatttt aaaagcatta ggtatccagg gcgaacaaag tggtgtcagc actggcgctc
     1441 actggctgcc agctcacgga gctaccatta cctctgtatc tccggtggat gataaaaaaa
     1501 ttgcagctgt aaaaggcgcc aacagagaag attacgacca ggtggtggct atcgcccagg
     1561 aagccttcaa agaatggcgt aactggcccg cccccaagag aggagaaatt gtgcggcaga
     1621 ttggcgaggc cttgcgtaaa cataaagagc acctcggtaa actagtgtct tatgaaatgg
     1681 gaaagagcct gcaggaaggc tatggagaag tacaggagat gatagacatc tgtgattttg
     1741 cggtaggatt atcgcggcag ctgcacgggt taaccatgca ttctgagcgt cccggccacc
     1801 gcatgtatga gcagtggcac ccgttgggta ttaccggcat tatttccgcc ttcaacttcc
     1861 cggtggcagt atggagctgg aactcgatgc tggcatgggt ttgcggaaac gtatgtatct
     1921 ggaagccttc cgaaaaaaca ccggtgacgg ccctggcctg tcaacgtata gtcgacaccg
     1981 tatttgccgc caataaggta cccgaaggcg tgtgtaacct ggtgatcggc gaccgggatg
     2041 ccggcgaatg gatgtcgcac gacacccgta ttccactggt atccgctacc ggttccaccc
     2101 gtatgggtaa agccgtagga gctgccgtag gacagcgcct ggggcgttct ctgctggaat
     2161 tgggtggcaa caatgccatt attatttcgc aggatgccga cctagatatg tccatcattg
     2221 gcgccgtatt tggcgccgtg ggcactgccg ggcaacgttg tacctctacc cgcaggctca
     2281 tcatccacga aagcgtatac gacgccttta ctgccaggct ggtaaaagct tattcacagc
     2341 tgcgtatcgg taacccgctg gatcagcata accatgtagg tccattgatt gataaagcgg
     2401 ccgttaacgc ttacctggat tccatagaac aggtaaaagc gcagggaggc agcttcctcg
     2461 tggaaggcgg cgtgctttcc ggggcaggat acgaatccgg ctgctatgtg aaaccttgca
     2521 ttgccgccgt ggaaaatacc tacgcgattg tgcagcatga aacctttgcc cccatcctgt
     2581 acgtcatgaa atacaagacg ctggcagaag ccattgctat gcagaatgat gtgccgcaag
     2641 ggctttcctc agccattatg accctcaact tgcgggaagc agagcaattt ctctcccatg
     2701 cgggatctga ttgcggtatt gccaatgtaa acatcggtac ttccggcgca gaaatcggtg
     2761 gtgcttttgg tggtgaaaaa gaaaccggcg gtggccgtga aagcggctcc gatgcctgga
     2821 aagcctatat gcgccgtcag accaatacta tcaactactc taccagcttg cctttggcac
     2881 aaggaatcaa gtttgatttt tagctattga gtataaagcg aaagacataa aactattgag
     2941 gcgaatgacc aatgcgattt taaaatattc gcaaagatta ttcgcctcaa tagttttatg
     3001 tctttcgctt tatgctttct gctttttgga ttccagcccc gaggcgctag ccccggagct
     3061 tttaactttc atgactggaa ctgctacccg atcagatttt taaaagcggt tgataaaatg
     3121 cgtgactaat attcttttgc gcagtctcgg ctgcacctta ctctacatac tgcgtgcaca
     3181 gttctaaaaa tagtagcgag gttagagaac cccgcttttc gttaaacgga aaccatgctt
     3241 atgagaaaag taaaaatggc gggaagccat taaatactct tctgaatata aatattaaac
     3301 ttttttttga atattcatat tcaacttttg tgctacgggt gcaccgttgc tgacctattt
     3361 cacggtcaaa acctgtccgc ttcctctgtc ataaagggtt ttgatctctt ttccccatag
     3421 tcccgtacga taaatcaccg cagtaatatt ttccggatca ctgcaaataa caaaggcttt
     3481 gcctttattt ctctttatca agtggttaaa tacgttggca gcctgctcag ggttatcggc
     3541 caatttgaaa tagtccagtt gcctcatgcg gacttttgcc cgctgagtag cagtttccac
     3601 agcacgatcc ccgaaatttc ccgtaccccc atttctttca ctgcgatcat actgctttcg
     3661 tccttctatc ctccaatcaa ccaataaata gcgcgtttat cattaaaatt taatgttata
     3721 ccgctttttc tataccttta tcgtttatca tcaagatatt tttagttgtt tttataggga
     3781 aaattattga acatgaaatt gtttagtcga gaggtagcag cccttgcagg ctgcattgcg
     3841 ttgatgactg catttacaac aagcgccgat gcacaaagta aagtccaggt ccccaaaaac
     3901 tggcagctct taagctacga taccgatagc gtgttcggta cgtctaccga aaaagcttat
     3961 aaagaattgt taaaagggaa gaaaagcacc ccggttattg tagccgtaat cgattccggt
     4021 attgataccc tgcatgaaga tctgaagaac attctgtgga ctaatccgcg ggaaataccc
     4081 ggcaatggca aggacgacga tcacaatggc tatatagacg atattcacgg ctggaatttc
     4141 ctcggaggaa aggacggcgc cagtctgaaa gaagactctg aagaggcagc tcgggaatac
     4201 taccgctata aaagcctgta tggcaatcct gattctgcgt tggcaaaaga ttcaaaagaa
     4261 tacgccattt ggcagcaatt gcaatcgaaa gtagaaaagc ctaactccca gtttaaggtg
     4321 cagtacaaaa gcatgtccaa gctgcaggaa aatgtgaaca aatgcgaaac catcctaaaa
     4381 aattacctgg gcaaagacga tttcaatgta gcgcaactgg acagtattca aacgaccaac
     4441 caggatgttt tgcttgcccg caatttcatg agccgcctgc taaaaagcgc cggcgatgaa
     4501 ccagctacct tcggcgagtt caaaatggaa ttcgatgagt acatgaatga actgaaacgt
     4561 aaggcagaag ccaccgatgt actcccaaac gctaaccgcg aaaggattgt aggcgacaac
     4621 ctcgaagata ttaacgacaa caaatacgga aaccaggatg tgatgggtac ctttgggttc
     4681 catggaacac acgtatccgg tattattgcc gcctccagga acaatagcgt aggtatcgac
     4741 ggcgtagccg acaatgtacg tatcatggcc gtaaaagcgg ttcctgatgg cgatgaaaga
     4801 gataaagacg tggcgctggc catccgctat gcagtggata acggcgcaca gattattaat
     4861 atgagcttcg gcaagccttt ctctcctcat aaagaatggg tggatgccgc ggtaaaatat
     4921 gcagaagaaa aaggcgtgtt gctggtgcat gccgccggta atgatggtgc aaacaacgat
     4981 tctgttgcca actatcctaa cccgaattac ctggatggcg gccgggctgc caactttatc
     5041 actgtaggtg ctatcagcac cggtacgatg cccgataaag tggcgagttt ctccaactat
     5101 ggcaagaaag aagtagactt atttgcgcca ggcgttcaaa tctattctac aatcccgggt
     5161 ggcaataaat acggctctgc cagcggtacc agcatggcca gccctgtagt agcaggtgtg
     5221 gcggcattgg tgctctccta ctaccctgag ctcagcgcca aacagttgaa atatgtgctc
     5281 gaaaaaagcg ctaccccact accggacggt tctactatgg ttaacaaacc aggcagcagc
     5341 gatgaaaaaa ttgctttttc agatttatct gttaccgggg ggctggtaaa tgcttatgaa
     5401 gcgttgaaac tggcggctac cattaaggga gaaaatgtga aagggaagaa acaacacaag
     5461 gcgaaggtta aaccgatcaa aaagaactaa tcagtatcga tcatactaaa aaagacccgg
     5521 ctgcgatgag attaccagcc gggtcttttg tttttaatgc agttatttaa cgaggcgcag
     5581 gctgagcggg taacggtata tcttgccctc attggcccgt accgctgcca cgatgctgaa
     5641 aataacattg aggaaccata atatctgcac caggcttccc catccccagg taaagctgaa
     5701 gttccaccat ggccgtgacc aaaacgtagc cactgaccag atgccataca gaatattttc
     5761 aacgatttta gcggcaataa cagccaggct ataggtgatc tgaaaattca cggcttcctt
     5821 gccctgatcg tccactacat gggaatcatt gcgtttaatc agccatagta ccagcgcccc
     5881 gataatattg cctacagtag ggatgatcca cataccaata aggccgccca ggtgaataaa
     5941 ggtactccag gtacgttctt ctttaggatt cataaaatat aagattaaat attaaaggga
     6001 agttaacagc ttattttagc atatcaaaag agaagaagaa aaaaactaca aacctgtaag
     6061 ccggattctg ttctccccgc tttcgcgggg agctgctatc atttatctgc ggcaacgttc
     6121 gcacgttgcc tgtatctgcc taccctcggt catcgggcga gcagccctca ggcgaccgta
     6181 tacatggcat ttcagcacgc aaggtttacc cgcacaaaca gttacctgcc tgcaccgtgg
     6241 gctcttaccc caccttttca cccttacctc taccaggtag aggcggttat tttctgtggc
     6301 acttgctgta cctccaccaa agatggaggc cccacccgtt aggtggtgcg ttgctctgtg
     6361 ctgtccggac tttccttttc gctgaacaag tcagcgaaac gatagcacgg tttgtagttg
     6421 aggcgcgaag gtaagaaaaa tattacctaa acgttatttc tgtagcgcca tagccatact
     6481 tggcgtggta ttgattaacg aagttggcta cttctggcgt ttgtcgcaat acctggtgaa
     6541 tttcatcccg cagctttcct ttacccacgc catgaatcac taccaggtta tgctgatgat
     6601 gactgatcgc caattccagg taacgttgaa aagcattgag ctggatagcc aggatggcaa
     6661 tattgcttaa acctttccag tttttttcca gggcctctat atgcaaatcc acctcctgtt
     6721 tgggcgtaag cgttgtttca ggctgcagct gtatcttgct tagcaggctg gcaaagttcc
     6781 cggatccgat agaggtaatg ggtgctttct ttttaggctg ctccggcgta ggttctggtt
     6841 ctggttcctt ctccggaaat ttatcaaata aaggataggt aatggtggct tctgccttgg
     6901 tgcgcaattg ttccagctgc acaaacattt gttttgcctt tattctccag gttttcttca
     6961 cagaggtagc caacttgggt tgcggctctt tcaggaagaa agtaaactcg aaccggggat
     7021 tgtcgttcag tgattcaaac agcaggtcag ccaggtagaa atgattatat ggctggatct
     7081 cattctttat ttccagatcc agctgattat tcagccagat ctgaaaatag aaacgcatgg
     7141 cgtgcggagt atcattgaac aggtgaaact tcatcagttt cactgtttca tctaaaccgt
     7201 ccatctggta taccggtaaa acagacagga acatgccctt atctgtttta aacacttcat
     7261 atttgcttct gtctactttg atttcgtcac cgggaatgag ccgtggtttt tccttcacca
     7321 gcttttgctg ggtaaaacga tggaaatatg ggaagtctat ctggtcgaga tacaccggga
     7381 aagaggtccc ttttatctcg atcattacca tgttatcatt caccagttca acaaccgttc
     7441 cttcttcttt tgagctcaac agcaatatcc tgtcgcctat ttggtatttc ataattgcat
     7501 tcttcagact gcaaaaatag aaatttgaaa ggatatgcgg gccagagata tccggaatat
     7561 cagaagtcga tatacttatg gttacgtttt tcagggtgcc ggcgcatgta atcatcaaca
     7621 gaaatgcggc cgcttccttc caccaggaag acaatcagta acagaagcac caagattgcc
     7681 aggcctgtag aaggatatac attaaataat ttagtaggag aatgtacgaa gaaaacggcg
     7741 cccaggagga tgggtatatt gacgatcacg gaaaaccgtg tcaccagccc catggcaata
     7801 aataaaccgc cgacgatgtg ggcaaataca atatagtgtc cgagcatgat tgacatggcc
     7861 gccatcgtag gccgctggct gatcatagac accaaagcat ctctgtccat cacaaacagg
     7921 acacccattc ccatgagaaa tacgcccagc agaatgcgta ctgcactcag ccaattgggg
     7981 ctatgtgtgt cgccccagtg ttcaacccgt tgtagcatgt tcataaaata taaattttaa
     8041 gatcaaagag ctactgtgaa gttacgaaaa agctgaaagc atatagcata aagcaaaaag
     8101 ctattataga ggagaattaa gcggatggca tccgctagaa tctcgtctat aatagctttt
     8161 tactttattt atgcctatgc cttaagcgtt ttgctttaca gccagtttac tgtgcgaata
     8221 gctgtagccg atgtaaatca ctaagcccat ggccagccag atagagaata cgatccagtt
     8281 cttcagggct atttctgtca tcaggtaaaa acagcttagc atgcctaata ccggtatcag
     8341 cgagagtttg cgggtagccg acagataagt aattatcagc gttaccacca caaacaggta
     8401 gaaaggaata ttatgtttcc atacattcca accgccttcc attgacagtt tgagcagtat
     8461 ttccttatta aacaggataa tcaggccgac taccagtgcg ggaacaatcc attgcccgtt
     8521 gatatagggc agctgaaagc gtttggtagt cgctttttcc tcccggggaa gtatcaaaac
     8581 gccgccgcat accaggataa aggcaaacag ggtacctatg ctggtgaggt ctgttacgat
     8641 cgtcagattg aggaacaacg ccggaatacc taccagcagg ccggttataa tagtggcata
     8701 ggaaggcgtt ttaaaccggc ggtggatggt gctaaaccgg cggggcaaca atccatcgcg
     8761 gctcatgctc atccagatgc ggggctggcc aatctggaat accagcaaga cgctggtagt
     8821 agccaccact gcactcacag aaatgagata actgatccat ggtaaatgta cctggtcaaa
     8881 aacaaatgcc aagggatcat ctaccttgag gttataaaat ggtaccatac ccgtcagtac
     8941 aaaagaaatc agtacatata ataccgtaca gataataagc gaataaatca tgcctttggg
     9001 caaatcccgc tgtgggttgg cacactcttc cgcagtagta cttaccgcat caaagccaat
     9061 ataagcgaaa aatacggccg ataccccttt catgacacca gagaacccgt ttggcataaa
     9121 aggcgaccaa ttcgccttat ttacatagaa aaaccctact acgatcacaa aaaggatcac
     9181 caatattttg agggccacca tgaagttagc gctccgttta ctttcctgga tacctacata
     9241 agccaggtaa gtaacaatta ccacgatgat aaaagcgggc agattgagaa ttatcgggat
     9301 accggcgata tgcggggccg cagcaatgag ggcaggactg gcgctatcat aattgctggc
     9361 cagccagggt ggcaaactca atcccagtcc cccgagaagg ttattgaaat acccactcca
     9421 ggaaatggcc acggcgatat tcccgatagc gtattccagg atcagcgccc agcctatcac
     9481 ccatgcggct aattctccaa aagtaacgta agagtaagta taagcactgc cagataccgg
     9541 cacccgggag gcaaattcgg cgtaacaaag ggcggaaaat ccacaagtaa tcgcagtaat
     9601 cacaaataac agggatacac ccggaccacc atggaaagaa gcttccccga tggtggaaaa
     9661 gatgccggcg ccaataactg ccgcaattcc catggcagta aggtccttta ctttcagcac
     9721 tttatgcatc ccccctgttt catgaccgtc tgccaatcca tctttggcat cttttaaaat
     9781 agtggcaagc gatttttttc gaaacagcga attagacatt ggctaaggaa ttacgtgtta
     9841 cagtttggct tttaatgtaa tttaaaaaaa tcctgttctg gtaaaataaa aatgctgatt
     9901 accctgatta atctttcaga aaaaaatcag tgtaaacagc attctcactt tcatcctgaa
     9961 taagacaagc gcgaatataa cgcgaattta aatacaaaac ttattgctgg cggtttaaca
    10021 ggtagttggc cagatccatc agcggtgcct tacgggacga cagtaccgcg atatggtcga
    10081 ggctttggaa ggccagccgg gtaaagcgtt ccttttcctt ttcggcccac tcatctacct
    10141 tgcaggcgcg gaacagttcc aacacccttt ctaccttgtt tgccggcgat gcttccatta
    10201 accggatcag ttcagctttt tgcgccgcgt tgcacagttc aaaagccttc agtaacagga
    10261 acgttttttt attcaccagg atatcgcctc cctgttgttt tccaaatttt tccgggtctc
    10321 cgaaagcatc caagtagtcg tcctggatct ggaaagcaat ccctacattt ttaccgaagt
    10381 tatacaggtg ttgctgattg ccctctcccg cgccaccgat gatagcgccc agctgcaggc
    10441 tggcagccag caataccgag gttttaaggc caatcatatt tacatagtca tcatattgca
    10501 cggcttccgg atccatagtt tcgaaatcca tgtccaactg ctggccttca cacacttcaa
    10561 tagccgcttt gttaaaaacg ctgatgatct tctgtttgta atgggcctgc accttattca
    10621 ggcgttcgta tacattgatc agcatcacat cccccgccag gatagcggca gaatcgccat
    10681 ataccgtatg aacggttggc ttaccgcgac ggaggggcgc cttatccatg atatcatcat
    10741 gcagcagggt aaaattatgg aaaagctcaa tggcactccc aacctccaag gcgtccgggc
    10801 gcagggtatc aaacaactca tttcccatca aacacaatac cggccggatt cttttaccac
    10861 ctatccccaa aatatgagag gccgcgtcat acaatttccg gggttgcgcc ggaaattgtt
    10921 gctgattaaa atgttgacta aactgcgcta ttaaatcttg aaatgactgc atcactcgtg
    10981 gctcgggttt tattatttac tctttttctt cgttgttttt ttattagcag gtttagccgt
    11041 tgctttctta gctggtttag cagccacttt ggccactgct ttctttgcag gcgctttcgt
    11101 tacagcagct ttcttagccg gtttagcagc cacttttgcc actgctttct ttgcaggcgc
    11161 cttcgttaca gccgctttct tagctggttt agcagccact ttggccactg ctttctttgc
    11221 aggcgccttc gttacagccg ctttcttagc tggtttagca gcccctttgg ccactgcttt
    11281 ctttgcaggc gctttcgtta cagcagcttt cttagccggt ttagcagcca ctttggccac
    11341 tgctttcttt gcaggtgctt tcgttacagc agctttctta gctggtttag cagccacttt
    11401 ggccactact tttttagcag gcgtcttagc taccgcggct ttcttagctg gtttagcagg
    11461 tacttttacc gttgcttttt tagcaggcgt cttagctacc gcggctttct tagctggttt
    11521 agcaggtacc tttaccgttg ctttcttagc aggtgcctta gctaccacag gtttcttcgc
    11581 aggcgctttg gctacagcag ctttcccggc aggtgcagcc ccccccttct taactggtga
    11641 ttttgctgcc ggagcaggtt cagccgctga ctttgctgat gttttgctgg ctggcttagc
    11701 ggctacttta tcagtagctt tcttcaccgg cacttttact tcttccttgc tgatagccgc
    11761 ctctttaaca ggcgccggcg tagcaggttt tgcaggcgct ggagtggcta ccggcgctgg
    11821 cgcagttgtt acagtaacag gcttttgttc tttctttttc ttcgctttct tttcagacgc
    11881 ggcaggctga gacacggcag aagtaaccgg ttcagctaca ggcgcaacag gcaccacatg
    11941 ggtttctgcc actacctggt ctaccactgg cactggctct ggctcaatgc gtggcgcttc
    12001 atgtgttttg agcgcgggtg tatgttccca gggcttacgc tgtttgtcgg cacggaactt
    12061 ctcctttttc cgtttacgtt catcgcgacg ttgttccttg cgttgatcat cccggcgctt
    12121 gggttgaaat gcaccaggag cagcaggtac agctgtgccg gtgagttcat cttccaggtc
    12181 gtagtccagc tggcgtttgg ccaggttggc cgctaccacc cggatactta ccttctcgcc
    12241 tatacgaaac ttgcgaccgg tgcgttgtcc caccagcgcg tattctcctt cgttgtactg
    12301 aaaatcttcc cgcctgttga ggttatgaat actaattagc ccttcgcatt tggtatccat
    12361 ggtttccacc cagaagccga aatgcgccac gccactgatc acgccttcaa aggtgtgacc
    12421 gatgaactgc tgcatatatt ctacctgttt atatttgttg ccggctcttt ccgcttccat
    12481 tgccttgcgt tccatctctg agctgtgttt gcatttctgc tccatttgtt tatccgggcg
    12541 tacgctattg gccaggcatt ctgccagtac acggtgtacc agtacgtcgg ggtagcgacg
    12601 tataggtgag gtaaagtggc agtaatcttc aaagccgagg ccatagtggc ctatgttatc
    12661 tatcgtataa atagctttgg ccatggtacg gatacccagg gtttccagca ccggctgttc
    12721 cggccggcct tttacccggg ccagcatatt attgaatgac tctgcaatgg tttccggacc
    12781 gctgagatca aacttataac caaacttacc tgcaaacagg gcaaaagttt tcagtttttc
    12841 aggatccggc gtatcgtgta cgcggtatgg aaaaggaata ggttgtttat taattctcag
    12901 ttttgctaca aaggctgcaa tagttttatt ggccagcagc ataaactctt cgatcagctg
    12961 gtgggcctcc ttactttctt tgaccacaat cccaacgggc ttacctgttt catccagttt
    13021 aaagcgtact tcctgggaag agaagttgat agctcccttc tcaaagcgct gtgcacggag
    13081 attttgggca atcctgttca gcagcagtac ctcgttccgg taaagacctt cttttgtttc
    13141 tataatatcc tgtacctctt cataggtaaa gcgatggtcg gaatgaatga ctgtccgccc
    13201 aatccagtgt tgttttattt ctcctttgtc ggtcatctgg aacatggccg agaaagtaag
    13261 tttatcttca tgcgggcgca gggagcaaag ttcattggat atcttttcgg gcaacatcgg
    13321 cagtaccctg tctggcaggt atactgaggt ggcgcgttta tcggcctcct tgtcaagttc
    13381 tgttccgggc aatacataat gacttacatc agcgatgtgt acgcccacct catacagccc
    13441 gtttttcagc aggcgaaggg aaatggcgtc gtcaaagtcc tttgcatcca ctgggtcgat
    13501 agtcatagtg aggaatttgc ggatatcctt tcgattgcgt acttccgttt ccgttatatt
    13561 ctcctggaga tggtctaact cggccatgac ttctttgggg aagttgagcg ggaagcctgc
    13621 ttcgatgagg atttccttca tcgccaggtc attggtgttg gttgcgtcga gtatttctat
    13681 gatttcacct accggtttac gggatttttc gccccaggcc actattttca ccacggcttt
    13741 gtccccgctt ttagcggttc cgagggaatt ggcgggaata tagatatccg gcataaacaa
    13801 tcccttttcc gggatcagga agccaaagct tttgctgacc tggagggtgc cggtaaattc
    13861 agttttattt cgtttaagga tatccgttac aatgccttcc atgcgggcgc cgttgttacg
    13921 gtcttgcgtc aatacatcta ccagtacttc atccctgtcg agggcggtat gcaggttttt
    13981 ctgcttcacc atgatgtctt tggtcaggcc ttccacgatc acaaaagcca ttcctgactt
    14041 tgttacttcc acaatgcctt taaaggattt cttctggata ttttgggggg gatggtggtg
    14101 gttccctttt ttatttttct tttttctact catgttagtc gtaagttatc attgaccagg
    14161 agctggcaga tgccggctta tgtagtcaaa aataaagtta ttaaataatt ctgcctctcc
    14221 gaagaggaag gatacttcca caggaataac agccatgcgg aggttttgtt ctgccagctc
    14281 ctttttcagc aggtgtagcc tcactgcatc cttttcggtg gtgatgacaa tcttttcggt
    14341 acctggcaag tcgctgcatt cttttttgat ttttgcgata tctttttctg tataataata
    14401 gtgatcggga aaggacagga ggtaaacctg gtcataacgc cgtttcagtt cattgagcaa
    14461 tggttcgggc cttgctatac cacaagccag caatacagtt gctgatgggg gaatttccac
    14521 cggttgatgg gtaaccatat cggacagggc gccgtactgc aaggtagtga aaaagagccg
    14581 ctgatgaggc aaagggttaa tttctttttc cagggcggct ttttctgcca ggctcatatc
    14641 cggcggacac ttggatacga tgatgcagtt ggcgcggtga taaccggccc ggccctctct
    14701 caggcggccg aatggcacta catgatcgcg ggtaaacagg cggctatagt cggtgatcat
    14761 gatattcatg cctggcttaa tggagcggtg ctggaaggca tcgtcgagca atatcacctg
    14821 ggtgttgggt tcatcgccca gcaactgggg aatagccagc atcctttctt ctccgacgca
    14881 gactttgata tcggggaatt tatcatggaa ctgcatcggt tcatccccga tatcttcggc
    14941 ggtgctatgt tcatcggcca ggaggtagcc gctggtacgg cggttatacc cccggcttag
    15001 ggttgctacg ttgagatggt ctttcagcag gcggatcata tattccacat gcggtgtttt
    15061 acctgtccct cctacggaaa ggttgccggc ggcaattacc ggcaggtcaa attccacggc
    15121 agtcagcagt cctttatcat aaaggcggtt gcggatccac atcaccaggc catagagcag
    15181 ggaaaaggga tataaaagaa aattcaggta tctgagcact gttgtttatt taaattgata
    15241 aatatgatcc ggggtcacca ctgtttgcag gggaatatcc cagggatcta cgtcctggat
    15301 ggcgggtacg ggttcaaaca gggatagccc caccgtgtac gccgtcgggc attgctgcag
    15361 gaagcggtcg tacatgcctt tgccgtatcc aacccgctgc cctttccggt cgaaggccag
    15421 taaaggtacg aagatgaggt ctatatcagc cggttgtact tcctccccat gctcgggttc
    15481 gggaatacca aactggtttt tgatgaggat ggtattggtt ttccagagat aatgaatcat
    15541 gtcgcctgtt ttcatatccg accgggaaag cgcccactgc aggccggggt attcatcccg
    15601 caaccatttt accagcggcc aggtatcggc ttcttttttt tctgaaatag gcaggaaaac
    15661 gtgcgccatc cggaaacggc cgtagtccag ctgccggcaa cggttcagca gccgcccgtt
    15721 caggtccagg gccgtattat cgtccatatt gagccgtagc tccaggaaat gttttcgtat
    15781 atccttttta gtggtcatgc cattaaagta tgcagcgagg cagacaacaa ctgtgcctgt
    15841 tgttgtacaa atgccttatc tacaggatta gcctgtggga tacgccctat cttgggatag
    15901 ccgctccagc gtacaatatc atcttcattg gtgtgataat cgccgttaaa cacccatcca
    15961 ataacaggta cgcctgtatg ttgcagcacc ctcgcagtaa gcatcgcatg gttaatgcta
    16021 ccaaggtaat tctgtgccac caccagcact ttcgcaccca gggccaggat caggtcgagg
    16081 gtcgatagcg tttcgttaat aggtaccagc aggccccccg cgccttccat gaccaacgcc
    16141 cggtccaggg gctggtattg tttcgacaaa gccacgatgc ggttgatatc aatattttta
    16201 ttttccagcc gggctgccag gtgcggagag gcgggcgcct tcagtagcca ggcctccggg
    16261 tgacaaactg acacgttatt ggatagcagg ctgccgacag tatccgtatc tgttccttcc
    16321 agcaaccctg tttgtacggg cttccagtaa tcggcctgta acgcttcggt tacacaggct
    16381 gcgctgatcg tttttcccac gccggttcct ataccggtaa taaatatgcg ttcactcatc
    16441 gacagcaaat atagggagaa tgtataaagt agcgccggaa accaatccta aagcgaccgg
    16501 gcggtatcga cccaattccg tattttcgta aacgtacaac ctcattttta tgaaatattg
    16561 tgataacata ctcgaaacga taggaaatac cccgatgatc cggctgcatc gcgttacggc
    16621 cactctcccc tgcaccgtgc tggccaaagt ggagtttttt aacccgggca actctattaa
    16681 agaccggatg gcggtaaaaa tggtagacgt agccgaacag aaaggactgc tgaaacccgg
    16741 cggcaccctg attgagggca cttccggtaa taccggtatg ggcctggccc tcgccgccat
    16801 tgtgaggggc tataaatgta ttttcaccac taccgataaa caatccaagg aaaaggtaga
    16861 catcctcaag gctgtgggcg ccgaagtaat tgtatgtcct accaatgtgg agcctgaaga
    16921 tccgcgctcc tactattccg tatccaagag gctggccacg gaagtaccta actcttttta
    16981 tgtaaatcaa tacgacaatc tggcgaaccg ggacgcccac tacgagcaaa ccggtccgga
    17041 gatctgggag caaacagaag gaaagatcac ccacctggtg gtggctaccg gcaccggtgg
    17101 caccgttaca ggcaccggaa aatacctgaa agaaaaaaat ccggatatac aggtatgggc
    17161 cattgacagc tatggttccc tgctgaaaaa atattttgaa accggtgaaa tagatatgaa
    17221 tgaggtatac ccttatatca cggaagggat aggagaagat tttgtgccgg agaattatga
    17281 tatgaccgtc atcgacaagt tcgaaaaagt aacggataaa gatgctgccg tgatggcgcg
    17341 ccgcatcacc aaggaagaag gcatctttgt gggctattcc gcaggatcag cgatacaggg
    17401 gcttttacag ctaaaagctt ctctcaaacc taccgacgta gtagtagtta ttttccatga
    17461 tcatggcagc cgttatgtag ggaaaatata caacgaccaa tggatgatgg aacggggctt
    17521 cctcgatgtt aaaacagtaa aagatgtggt caatggccgt cgcaatcagc cgctggtcac
    17581 aattggcaca gacgaaaaag taagcgaagc gattgcccgc atgaagaaat ttgatattga
    17641 acatatcccg gtggtaaagg acagcgaaat agtaggttcc atttctgaaa gtggtttatt
    17701 caaccgcctg atcgatgacg ccaatcttaa agatgccgcc atacaacagg tgatgcaagc
    17761 ttctttcccg ttggtgggac aagatacgcc gatagaaaaa ctgtcggtat acattaaccg
    17821 ggaaaatggc gctgtgctca ccaaagacga cagcggcaac taccatattg taacgaaata
    17881 cgacattatc caggccctgg gccgttagaa cgggctgaaa gcaaaaagct attatgtctt
    17941 gctggctgca ttactttctg ctttctgctt ttcgcttttt gctttatgct tactttcact
    18001 gatcagttag acagacaaat aacacttgct catccgccac agcggattat ttcgctggtg
    18061 ccttcacaaa ctgaattact ctggtccctg gggcttgaaa aagaagtggt gggcatcacc
    18121 aaattctgcg tgcgcccgtc tacgtggttt cgcgaaaaaa cgcgggtagg cggcaccaaa
    18181 aatatacatc ctgatattat ccggtcgctg aatccggacc tgatcattgc caacaaagag
    18241 gaaaatacag cggctgatgt aactgcatta atggaacatt acccggtatg ggtaagcaat
    18301 atacaaacat tggatgatgc tgttgagatg atatccggca taggagcaat tactggccgg
    18361 cagtcggcgg caactgacat ctgcacccgt atacaggcgg gctttagcgc gctgcagccg
    18421 ctcgctgaac cggagcccac tgcctacttt atctggcggg aaccatggat ggtagccgga
    18481 ggcgacacct ttattcatga aatgctgcgt gcctgcgggt tgcagaatgt gttcgggtcc
    18541 cggccccgtt atccgtcggt gactgcggaa gagctcttcc atagcggatg ccggcgggta
    18601 ttactatctt cggagcccta tccttttaag gaaaaacata ttgctgaatt gcagaccatg
    18661 ctgccggagg cacaggtgca gttggtggac ggagaaatgt tttcctggta tggcagccgt
    18721 ttactggagt cgccggctta tttccaatct ttgctgcatc cttccatata acgaggcaac
    18781 cttcttcttt tcatttgcgt aaacagtgaa tagatcaaca aaaaacgcac atttatggaa
    18841 agaagagatt ttgtttccaa cctcggacta acgctggcac tggcttgcac agcgggattg
    18901 gcagcctgca gtaaaggcgg cagcaatgac aaccccactc ctacgcctcc ggcgggcggc
    18961 aatgcaaaac tcacgctcaa tctggccagc gacctgccta atgtaggcga ttttaaaatc
    19021 tccaatggcg ttatcctgat ccgtacaggc agcggtaata cggcatcggc cttcaccgcg
    19081 ctgtccagca cctgtacgca ccaggggtgt accgtagcta cctacaacac cagctccaag
    19141 ttaattgagt gtaatgcgcc ttgtggccat ggtagcagat atactactac cggtgccgtg
    19201 aatacaggtc ctgctacggc ggcattgtct gccttcaccg taaaagttga tggaaatgtg
    19261 ctgaccgtca gctagtgatt ttggaggaaa tccagtaccc atgcagcaaa tgcggcgcta
    19321 cgtactacgg aattatgatc gccggtaact gttccatgca tacctgctgg catcatagcg
    19381 gcgagtgatc cgccagtgtc attatcttca tctttatctc ctccaataac caatactggt
    19441 tgctgtactt tggccagttc ctgcggtgtt gtggtaggct ggccaaactg catccaggcg
    19501 agggcgcgct gatccaggcc tgccttctgc acatttttca ccatcgcggc caatgccggt
    19561 acaggtttcc cagagagggc ttcataaaat tgctggcggc ggggccaggc tggattggtg
    19621 aaagcggttc ccataccgcc tataacggcg ctggatatac gattatccag taccagcaaa
    19681 cgtgcggtga taatggatcc acgggaatat cccactacct ggtaatgctg gagtcccaac
    19741 tggctggcca gctccatcac atccttcgcc tctgcatcgt gcaggtaggc tgtactgtcc
    19801 tgcggatgac ctgaggcgcc attacctctc atatccagtg ttataacgcg aaacccatgc
    19861 aagagcaaag agtcatataa ggcggttctt ttccaggatt cgccgtctac aataaagccg
    19921 tgtattaata ttaccggttt accgcttcct tttaccgagt aatgaatatg ggtaccgtca
    19981 aaagaagtgt aatacaggag agagtcggct acttcggacg taaaagcctg cgcaacgggc
    20041 atcttcagcc ataataacag taacaggacc aggtattttt tcatatggaa ccgggttaag
    20101 aaagggggaa aatacatttt tctgttggta gatttaatac ataagcgctt acttttcgct
    20161 ataaatcttc tatttaactc cttatatttg ctttcctaaa aaataaaaca catatcagag
    20221 tatgggaaag tacagagctg gcgtattatt cggcgaagag ctggatgcgc tgtataacga
    20281 tgccaaaaac aacggatttg ctatgcctgc cgtgaatgtt gtgggaacta actccgtgaa
    20341 tgcggtactg gaaacagctg ctaaggtaaa ttcaccggtg attatacagt tttctaacgg
    20401 tggtgcacaa ttttttgccg gtaaaggtat gccgaatgac aagctgcagg cgaatatttc
    20461 aggtggtatc tccggtgcta aacacgtaca tgaagtagct aaatattatg gcgtacctgt
    20521 agtattgcac actgaccacg ctgccaagaa atggctgcca tggatcgatg gcttgctgga
    20581 cgcgggtgaa gcgcatttca aacaaaccgg tcagccactg tacagctctc atatgctgga
    20641 cctgtctgaa gaacctattg ctgagaacat cgaaatttct cataaatatt tcgagagaat
    20701 gaacaaactg ggtatgtcta tcgaaattga gctgggcgta actggtggtg aagaagatgg
    20761 cgttgataat tccggtgtag ataacgctaa attatatacg caacctgaag aagtagctta
    20821 tgcgtacgaa atcttatcta aagtaggtcc ccgtttcacg gtagctgccg ctttcggtaa
    20881 cgtacatggc gtatattctc cgggtaacgt agagctccgc cccgtgatcc tgcacaacag
    20941 ccaggaattt atccaggaga aatttaaaac cg
//
