LOCUS       NZ_JABAOB010000002     20975 bp    DNA     linear   CON 23-OCT-2023
DEFINITION  Chitinophaga sp. Ak27 Ak27-scaffold_2_length_936559_cov_140.323,
            whole genome shotgun sequence.
ACCESSION   NZ_JABAOB010000002
VERSION     NZ_JABAOB010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga sp. Ak27
  ORGANISM  Chitinophaga sp. Ak27
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1  (bases 1 to 936559)
  AUTHORS   Yin,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2020) State Key Laboratory of Plant Genomics,
            Institute of Microbiology, Chinese Academy of Sciences, Beichen west
            road, Bejing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-AUG-2019
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 246.8x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/23/2023 02:22:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,312
            CDSs (total)                      :: 6,224
            Genes (coding)                    :: 6,211
            CDSs (with protein)               :: 6,211
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4, 4 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 13
            CDSs (without protein)            :: 13
            Pseudo Genes (ambiguous residues) :: 0 of 13
            Pseudo Genes (frameshifted)       :: 0 of 13
            Pseudo Genes (incomplete)         :: 11 of 13
            Pseudo Genes (internal stop)      :: 2 of 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:12:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 498249
            Orig. end                         :: 519224
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABAOB010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20975
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20975
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20975
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10975](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10975
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            627..2519
                     /locus_tag="HGH90_RS09830"
                     /old_locus_tag="HGH90_09830"
     CDS             627..2519
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019552.3"
                     /locus_tag="HGH90_RS09830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09830"
                     /product="alginate lyase family protein"
                     /protein_id="WP_168764163.1"
                     /transl_table=11
                     /translation="MSSLNTVINGLKVVRNMGWRYVAFRSVHELNRRTGRLKKRFPQAP
                     AFQRYLSLDEWKQQSVVFFFQSREEVTAARKPTPALAARFKQLKEGKLTFFNGASLSLG
                     KDFSWMKNPDSGFLYNGEQHWTEVNDYSLEAGDIKFVWEKARFAYLYDIIRYDHHFEKD
                     NAALVFNDILSWISANKVNSGPHYKCSQEISLRVLNWTFALYFYRHSPALTAEIFDQVQ
                     YAIYWQLHHVFHNINFSRIAVRNNHAITETLALYLGGLLFPSLPGAAAWKELGKKWFEE
                     EIAYQVYDDGTFLQFSMNYHRVVIQLFTWALRLSELNGESFARQVKEKAVKSLRFLRVC
                     MNDSNGWLPNYGANDGALFFRLNDQHYRDYRPQLEALAVLLQMGAGFPETNEDLYWYGL
                     RPAAGNDTVLEKDKVLYSFPEGGYFVCREKETLTFLRCGNHKDRPSQADNLHLDIWHKG
                     ENLLMDAGSYKYNTDETTLRYFMGTASHNTVMLGHYDQMLKGPRFIWYNWTQCSRARLY
                     ETPDEYIWEGAISAFQQVGADIVHIRQVRKKKNAAEWIIKDHIQHKPGHLSMRQLWHTC
                     TPEKLNTRSEDSSGAILQPSCQPGMYSSLYGVKEKNSSIVFTTTADTIITEIII"
     gene            2526..3803
                     /locus_tag="HGH90_RS09835"
                     /old_locus_tag="HGH90_09835"
     CDS             2526..3803
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024968.3"
                     /locus_tag="HGH90_RS09835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09835"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_169190978.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.9e-12,
                     bitscore: 42.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILLVHQYFLEEDDPGGSRWNEITKSWTEQGAEVTVLGGMMHYN
                     GSAKREEYKGKYFVKKQQGAITVWRCHVSESYNANFLGRLWGYFSFMFSSLWAGLFKVK
                     GKFDVVVVTSPPLFVGFSGYLLSRLKRMPLVFEVRDLWPESAIDTGVLKNKLVIKLAYW
                     VEDFIYRKAAMINVLTPAFYNTLRDKKNVPEQKLIFIPNAADFSLSDHLLESFDRDSFR
                     REHQLSDKFVITYVGAHGVANHLEQVLDAGKALEDTPVLFLLIGQGMEKPRLQQLAAEK
                     GVKNVRFLDAVPKADVFKYILASEMGASILKKVDTFKTVYSNKTFDYMACRKPILMAID
                     GVSRELVETAGAGCYVEPENTAAYNTIIRQYLKDPQRLQTEGDSGFRYAKQNFDRQVLA
                     SRYLDFIRKKITKEIKANNALVQEPV"
     gene            3778..4389
                     /locus_tag="HGH90_RS09840"
                     /old_locus_tag="HGH90_09840"
     CDS             3778..4389
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014221486.1"
                     /locus_tag="HGH90_RS09840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09840"
                     /product="sugar transferase"
                     /protein_id="WP_168764161.1"
                     /sec_met_domain="Bac_transf (E-value: 6.9e-66, bitscore:
                     216.6, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHWYRNLFKPLMDITAALLALVILSPVMLILVLLLAIANNGRPFF
                     LQPRPGKNGRIFRVIKFKTMNDRKDANGRLLPDEVRLTPVGKFVRKTSLDEIPQLINVL
                     KGDMSLVGPRPLLVDYLPLYNDTQHRRHEVRPGITGWAQVNGRNAISWEQKFAYDVWYV
                     NNISFALDLKIIRMTLQKVIKSEGINAAGVATMERFMGNG"
     gene            4409..4990
                     /locus_tag="HGH90_RS09845"
                     /old_locus_tag="HGH90_09845"
     CDS             4409..4990
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007209919.1"
                     /locus_tag="HGH90_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09845"
                     /product="acetyltransferase"
                     /protein_id="WP_168764160.1"
                     /transl_table=11
                     /translation="MYLFGAGGHAKVIIEILQSGKVPVEGLFDGNPDLKQVWQYPVIAY
                     SPEMPVAAIIIAIGKNAVRKNIAEQLSIPFGTALHERANISPSAMIAEGTVIMAGATVN
                     ADVLVGKHCIINTNASVDHDCVLEDFVHISPNAALCGNVKVGEGAHIGAGAVVIPGITI
                     GKWAVIGAGAVVTKDIPDHSVAVGNPARKR"
     misc_feature    complement(4994..5003)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.22"
                     /tool="antismash"
     gene            5006..6181
                     /locus_tag="HGH90_RS09850"
                     /old_locus_tag="HGH90_09850"
     CDS             5006..6181
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014221483.1"
                     /locus_tag="HGH90_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09850"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_317166139.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.9e-98,
                     bitscore: 323.3, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.6e-07, bitscore:
                     26.2, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNKKIWLSSPHMGTKELEFIKDAFDTNWIAPLGPHVDGFERDLS
                     TYTGAAHVAALSSGTAALHLALITVGVAPGDEVICQSMTFSASANPIAYLGATPVFVDS
                     ETSTWNMDPALLEQAIIDRIENGKKPKAIIPVHLYGMPAQMNEIMAIANRYEIPVIEDA
                     AEALGSWYREQACGSIGKLGILSFNGNKIITTSGGGALISNEEALISHSRFLATQARDA
                     APHYQHSHIGYNYRMSNVCAGIGRGQMLVLEERAAQRRANYRHYVAQLSDLPGVTFVSE
                     PVGFFSNRWLSTILVNPAQSNGITRETIRLALDRENIESRPLWKPMHMQPVFEKMPAYV
                     NGVSEKLFDNGLCLPSGSNLTPADLWRVTDVIRGLFAAAKVNASRTYQSQD"
     gene            6278..7855
                     /locus_tag="HGH90_RS09855"
                     /old_locus_tag="HGH90_09855"
     CDS             6278..7855
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024974.3"
                     /locus_tag="HGH90_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09855"
                     /product="gliding motility-associated C-terminal
                     domain-containing protein"
                     /protein_id="WP_169190979.1"
                     /transl_table=11
                     /translation="MTPLLLKYSDALSGVSKHLAAVLFFIISALHPVTAQDILLKNPSL
                     EGTPGKDKVPDLWKPRNTPDVQPGTFDINLPPSNGATYVGMHSGPAYLEAISQEVSLIG
                     GKTYTIALDLAYATKYSSLTCYGNLTVYGGNTPTDTAERLWSSGAFTHTSWKRYSFTFH
                     PSRSYKFITFMADATIPCDKSIYGSAVLMDNLSAALLETPQLTLSLKNTCKGEHTGEAT
                     VTVTGVSATCAIRWSRAGETTSRITGLEPGDYDVTVTHPNGVSVTQHFTIIGWEVKSKI
                     TVTPSRCYGQHNSTIALETTGGTPPYRYYFNGSTTGTYTASFEKLSPGNYSIRIKDEEN
                     CAEQIDNISVVEPAPLAIAGIRKKDISCATTFDGKIALNVTGGTQPYTYSLDNGLWQPD
                     SSWGGLDAGNFHFRIKDAHDCETDGQADIIRNNRECAVFVPTAFTPNGDGLNDLFRAKV
                     HDDVHDYHLEVYTRWGQTVFSTNDPEGVWDGTFKGNPLPGGSYVWMLLYTDSKQQARKQ
                     TGTVTLIK"
     gene            complement(7845..8585)
                     /locus_tag="HGH90_RS09860"
                     /old_locus_tag="HGH90_09860"
     CDS             complement(7845..8585)
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030145 - manganese ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039343.2"
                     /locus_tag="HGH90_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09860"
                     /product="CpsB/CapC family capsule biosynthesis tyrosine
                     phosphatase"
                     /protein_id="WP_168764158.1"
                     /transl_table=11
                     /translation="MLFFRKRNTDQAVPAQLLAFMGTDIHSHLIPGIDDGVPDVATAMA
                     FIEQLQHMGIQKIVTTPHIMMDRYPNSAATIAAPYQEVVEALARKNNTIPFHYAAEYYM
                     DEQFETLLQQPLLTLSGNKVLVEISFISPPLQLAQWLFDIQAAGYQPVLAHPERYAYYH
                     ADIVKYEQLKKQGCLLQLNLLSLTGYYGKHVQQAAEKLMAAGLPDLIGTDLHHEKHLQA
                     ITGIAKNNKLRKLLDTYPFGNATL"
     gene            complement(8623..9096)
                     /locus_tag="HGH90_RS09865"
                     /old_locus_tag="HGH90_09865"
     CDS             complement(8623..9096)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0033745 - L-methionine-(R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014222474.1"
                     /locus_tag="HGH90_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09865"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_168764157.1"
                     /transl_table=11
                     /translation="MAEDLHVVQGNKEEQYRSLIPQIKGLLDGEPDLVANLANVAAALK
                     EQFGWFWVGFYLVKGEELVLGPFQGPIACTRIRKNKGVCGTSWAQATTLIVPDVEAFPG
                     HIACSSLSKSEIVVPLIRNNEVKAVLDVDSESLSHFDETDQRYLEEIVALIVI"
     gene            9275..9805
                     /gene="idi"
                     /locus_tag="HGH90_RS09870"
                     /old_locus_tag="HGH90_09870"
     CDS             9275..9805
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018616270.1"
                     /locus_tag="HGH90_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09870"
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_169190980.1"
                     /transl_table=11
                     /translation="MKSPDVILVNEKDEAIGTMEKMEAHQKGVLHRAFSVFIINDAGEL
                     LLQRRALEKYHSAGLWTNACCSHQFPGETTAAAAHRRLQEEMGFDCELHEIFAFTYKSE
                     FDNGLTEHEFDHVLLGVYNGNISPNAAEVCDYRYLPTGQILELIKNEPDTFTIWFHKAL
                     PIVLEHMKIPSVG"
     gene            10001..10975
                     /locus_tag="HGH90_RS09875"
                     /old_locus_tag="HGH90_09875"
     CDS             10001..10975
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015869.3"
                     /locus_tag="HGH90_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09875"
                     /product="hypothetical protein"
                     /protein_id="WP_168764155.1"
                     /sec_met_domain="T1TS (E-value: 9.6e-89, bitscore: 294.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTIQMPTISYPFTSGVNHHVNEAQQHITNWVQTHGLITSATALK
                     RFEKARFAWLAGRAFPDAALHELCIIADFNTWLFILDDQCDEAAVGRKADYLKSVMAGL
                     MDILQTNQTVTLASGGPLAAGLSSIWDRMRAISSPAWRLRFIRSMQDYFMSCIWEAENR
                     EAGRVPSVEDYIHMRPYTGALLADIEAIEIIEKIYLPRPVVEQALLQRMIQACNNVVCW
                     SNDLFSCTKESRQGDVHNLVLVLQHQRQISLQEAVNQAARMHNEEVAIFVALEKLLPLK
                     GDETDYELLRYVAVLRSWMVGNFDWSVKDTGRYGLEQQAIVAA"
     gene            complement(11022..12050)
                     /locus_tag="HGH90_RS09880"
                     /old_locus_tag="HGH90_09880"
     CDS             complement(11022..12050)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HGH90_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HGH90_09880"
                     /product="hypothetical protein"
                     /protein_id="WP_168764154.1"
                     /transl_table=11
                     /translation="MLTLDKREAQVLQRAIHQWEQEQLLTTEQASRLRQSYKVVSTDWQ
                     TLTLYIFIAAVSCALMAFGSLVLDEKWIEIIRKKFSMTDGVIAVLFAAVSIFLCYEGWR
                     RNRHQPLFSFNRELFWLLPVLSIGVSVVYLGKSLQYLEGNYGVFWLLATVCYGVLGIAL
                     RSRLMWIATLLCLVPAYVKLTYYLTGDAAFFLGMNLPCRMALLGVLLIGMAWGLRQLQV
                     YAPIKNISWTGGWLLFIISGWLISIFGNCGTWEEWQQLRQIHLLQWVIVYSLQCVGMIL
                     LGIRVKDDLLRDLGVIFLLLDLYTRYFEYLWDHTNKGLFFGILALSFWWVGRLIEKRIK
                     RS"
     gene            complement(12062..12769)
                     /locus_tag="HGH90_RS09885"
                     /old_locus_tag="HGH90_09885"
     CDS             complement(12062..12769)
                     /GO_function="GO:0022841 - potassium ion leak channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0071805 - potassium ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018446.3"
                     /locus_tag="HGH90_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09885"
                     /product="TMEM175 family protein"
                     /protein_id="WP_168764153.1"
                     /transl_table=11
                     /translation="MSVIKEPKPLHRVFELERLIFFCDMVFAVAIALLVIEIKLPALPV
                     KMPVDRDYWELMRPTAFELLAFAVSFIFIGNFWVRHLQLCRLLQNYNEGLIHRHLFFLF
                     FIVLFPFSTSALLHTSSHFMLPFFIYLCNLTGCLAALFWISYFIFQKNPDLATEGHHTE
                     KTLLYQRLKYGFLTMATGFTVIAMTYFLYPDNTAYQRISYMAIPALALFNHFRLKIKKR
                     NTLRLVHKIGPHS"
     gene            12936..14282
                     /locus_tag="HGH90_RS09890"
                     /old_locus_tag="HGH90_09890"
     CDS             12936..14282
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1076: RND efflux
                     system, outer membrane lipoprotein,"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF014385.3"
                     /locus_tag="HGH90_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09890"
                     /product="TolC family protein"
                     /protein_id="WP_168764152.1"
                     /transl_table=11
                     /translation="MRCRYILFTLLLWTQTTIAYGQVDTSRSGNYDFNLANCIQYGLAH
                     QNDVVNARLDVNFSQEQIKEYTGKFLPHVNVNASITDNLKLQTSLIPDIANGNYDKKIP
                     VQFGTKWASAATGQVDQVIFNSDYFLGLKASRVYGDLSKKTLKRTEIDTRVAITKAYYA
                     ALAAEENIRLAKSNMTQLSKTLADTKARYDVGVAERVDVDRIQVSYNNIVTDIETQIRD
                     LVYAMQLLKFQMGMPQENKLTLTETVQDLNADVFIADTVDYQVQDRIEYSMQTTQVTLD
                     ELSLKSKKLGILPQLNAYVNYGYNYFSTKFSDLYKTGYGASALGLTLKWPIFAGTERYH
                     QIQENRITLEKSRNTLQYIGEQIQLDVANANTQYQNNKSRYVTQKTNMDLTQGIYDRIV
                     LKFEQGVATSLDVTSAENDLKQAQVNYVQALLNTLTSKTDLDKAMGKIK"
     gene            14316..15473
                     /locus_tag="HGH90_RS09895"
                     /old_locus_tag="HGH90_09895"
     CDS             14316..15473
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR01730.1"
                     /locus_tag="HGH90_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09895"
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="WP_168764151.1"
                     /transl_table=11
                     /translation="MYPVNYKRTFYVAGMMLCVACGNSKKQQQQQAAMMGKMKPTVVAV
                     EVTPASYTVAEKFPATLVAHDVVSLRPDVTGYLEAIRVPDGSSVTKGQPLYDIDRSRYA
                     AAYGQVAASQEQAEADLAQKTRDYERYKSLLEHDAISKQTVDQANTAMLTAKANLTAAK
                     AAVAKAGTDVSHAVVKAPVTGKIGIAQIKVGDIVNAGQTLINTIVNEHPMFADMDIPQS
                     RLPEFQRMQKGQGDHKFFIQFGDGTRYGEEGKILTINNIVDPQTGTVRVRLVFQNSDGM
                     LKSGMSIVAVMQYGTPGTQLAIPAKAIIQNLSETSVYTLSKDNVVAARDIIPGPVTDTM
                     LLVTSGLNAGDRIVVEGLQRVKPGDTVNIAGPGAAPGTAPGAGKH"
     gene            15494..18667
                     /locus_tag="HGH90_RS09900"
                     /old_locus_tag="HGH90_09900"
     CDS             15494..18667
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0042908 - xenobiotic transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) RND_efflux"
                     /gene_functions="transport (smcogs) SMCOG1049:
                     AcrB/AcrD/AcrF family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012789641.1"
                     /locus_tag="HGH90_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09900"
                     /product="multidrug efflux RND transporter permease
                     subunit"
                     /protein_id="WP_168764150.1"
                     /transl_table=11
                     /translation="MISKTFIERKNTTIVIAIIIVIVGLICMFNLPIAQLPDIAPPVTD
                     VRANYVGANSTTVEETVTTPIENQVNGTPGAMYIQSVSANDGSMSITVTFKLGTNPDIS
                     TLDVQNRVSLALPSTPDEVRRVGVTVKKRSNDMLMVIALNSPKGKHSREFLDNYLNIYL
                     KPELARISGVGDVNAFSQDYSMRIWLNPDKMAALGLTAGDISRAITEQNQQVPAGSVGA
                     PPMGRSQAFEYTVSVKGRLATSEEFGNVVVATSPNGGLVRLRDVARIDLGSFTYAIEAK
                     ADGKTGSGMAIYLSPGANALDVNDRVIAKMKDMAKSFPDDVNWLIPFETTSFVKISIDE
                     VIQTFIEALVLVVIVVFVFLQNWRATLIPILVIPISLIGTFIFFQLLGFSINTLTLFGF
                     VLAIGIVVDDAIVVVEAVQHHIDADLMSPREATFKAMAEVSAPVIAIALILAAVFVPVA
                     FIPGVSGRLYQQFALTIAFSVLLSAFLALTLTPALTAILLRPAHLTKQSHGLNKLFFKF
                     NEWFGRFTNRYGNGVKHSIRFTPAVLIILGVLFAIAAFLFKKTPTTFVPQEDMGALFIA
                     LELPEASSTERTKEVVAEISNILTKDSAVSHFFGITGINFVANATKPNSGTFFVSLKPW
                     DERYAHGDNINTVLGRIQGAAGRIIGANVICIPAPTLRGLGTSGGFSFILEQRSNPDIN
                     QFLQVMGQFLMAANQRPEIARAYAFFSANTPQFNVEVDRDKCKQLGVAVSDVFNALQTF
                     LGGLYVNDFTKFSRSFRVVLQADSLYRTSINNLNTYYVRNNNGQMVPLSALITTKKSAG
                     APVINHFNLYRSVEIDGDSKTGYSSGDAINALKEVAASVLPENFSYEWANVSLQEIEAG
                     NSSLLIFGLSILFVFLLLTALYESWSVPFSVLLAVPVALFGSIVALSLTKQANSVYSQI
                     GLITLIGLAAKNAILIVEFCKERVDRGMPLLEATLEAVKLRLRPILMTSFAFILGVLPL
                     CLAKGAGAASRVNIGFTVVGGMLAATLLGIFTVPVLYVLITKLAYGKKKLAELEAHGNE
                     EKKPKGLGE"
     gene            18678..19439
                     /locus_tag="HGH90_RS09905"
                     /old_locus_tag="HGH90_09905"
     CDS             18678..19439
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019846.3"
                     /locus_tag="HGH90_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HGH90_09905"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_169190981.1"
                     /transl_table=11
                     /translation="MKNTERFSTRVENYVKYRPHYPAAIIPYLAKEAGLTRDTVVADIG
                     AGTGISAQPFLDNGNKVYAVEPNTEMREMAEKLLHRYPGFQSVAGSAEYTTLPDNSIEL
                     ILAGTAFHWFDQSATAAEFQRIGKDNAVIVLMWNVRQSELPFEKSYEKLLHQYGTDYKE
                     LQHRNVGASQLASFFAPAAIHETSFQNAQIFDFAALKGRMLSSSYVPEKDHPSYPAMMK
                     DLEDIFWKYQEQGMVKFHYETKLYWGRILKK"
     misc_feature    complement(19494..19510)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.12"
                     /tool="antismash"
ORIGIN
        1 aaaactgctg aacagattct ctttgtaggc aatactatga ttgatacgct cctgaaacaa
       61 cggagtcgtt ttacgccgcc acccatatgg gaaaaagccg gcctgcaacc ccagcaatac
      121 ctggtaatga cgcttcatcg ccccgcgaac gtagatgaag aagataacct gtccttgctg
      181 atcaatgaaa ttatgaacaa tagccagcaa ttgccggtca ttttcccggt acacccgcgt
      241 acggccaaga acctggaaaa aatagcagtg gcgcatcccc gtctacacct ggtagagcca
      301 ctgggttacc tggaattcaa ctacctggta gaaaatgcaa aagcggtgat caccgactcc
      361 ggtggcatta ctgaagaaac taccgtcatg ggagtaccct gcatgacact gcgggattct
      421 accgaacgtc ccgaaacatg tattaccggc accaacgaat tactgggcac cgatcccaaa
      481 gcattggcgc ccgctatgca gaaattattt gccgggcagt ggaaaaaagg agctgtcccc
      541 gcgctatggg atggcaaaac atcagaaaga attgtagaac acctgacaaa aatatttgct
      601 gtaaaacagc aggagacagc agtagtatga gtagcttgaa tacagtaata aatggactga
      661 aagtagtgcg gaacatgggt tggcggtatg tggcattccg ttctgttcat gagttgaacc
      721 gcaggacggg acgccttaaa aagcgttttc cacaggcgcc tgcgtttcaa cgttacttgt
      781 cattggatga gtggaagcaa caatcagtag tgtttttctt ccaaagccgc gaagaagtaa
      841 ctgccgcgcg caagcctacg cctgcgctgg ccgcgcggtt taaacagctc aaagaaggaa
      901 aactcacctt cttcaatggc gcttctttat cgctcggcaa agacttttcc tggatgaaaa
      961 atccggattc aggattttta tataatggag aacagcactg gaccgaagta aacgactatt
     1021 cactggaggc aggcgatatt aaatttgtat gggagaaagc acgttttgcc tacctgtatg
     1081 acattatccg ctatgaccat cactttgaaa aggataatgc cgcactggtg tttaatgaca
     1141 tcctttcctg gatcagcgct aacaaggtaa acagcgggcc acactacaaa tgcagccagg
     1201 agatcagcct gcgggtgctc aactggacgt ttgccctgta cttttaccgg cattcaccgg
     1261 cgctgacagc agaaattttt gaccaggtac agtatgctat ttactggcag ctgcaccatg
     1321 tatttcataa tatcaatttt tcccgtatcg ccgtacgtaa taatcatgcc atcacggaaa
     1381 cgctggcatt atatctcggc ggactcctgt tcccgtccct gccaggcgct gctgcctgga
     1441 aagagctggg taagaaatgg tttgaagaag aaattgctta ccaggtatac gacgatggca
     1501 cctttttgca gttttccatg aactaccacc gggtggtgat ccagctgttt acctgggcat
     1561 tacggttatc ggagctcaac ggcgaatcgt ttgcgcggca ggtgaaggag aaagcagtta
     1621 aatcattgcg tttcctgcgg gtatgcatga atgatagcaa cggttggctg ccgaactatg
     1681 gcgctaacga cggcgcctta ttcttccgcc tcaacgacca gcattaccgc gattaccggc
     1741 cgcaattaga ggcgctggca gtgttgttgc aaatgggcgc cggattcccg gaaaccaacg
     1801 aagaccttta ctggtatgga ttgcggccgg cggctggcaa tgacaccgta ttggagaaag
     1861 ataaagtact gtattcattc ccggagggcg gatattttgt ttgcagagag aaggaaacgc
     1921 tgactttcct ccgttgtggc aatcataaag acaggccctc ccaggcagat aacctgcacc
     1981 tcgatatctg gcataaaggt gaaaacctgc tgatggatgc aggtagctat aagtataata
     2041 ccgatgaaac caccctgcgt tatttcatgg gtaccgcttc ccacaacacc gtgatgctgg
     2101 gtcattacga ccagatgctg aaaggccccc gttttatctg gtataactgg acgcagtgct
     2161 cacgggcaag gttatacgaa acgccggatg aatatatctg ggaaggcgct atcagtgcct
     2221 ttcaacaagt gggcgccgac attgttcata tccgccaggt gcggaagaag aagaatgcgg
     2281 cggagtggat aataaaagac catatccaac ataaacctgg ccacctgtct atgcggcagt
     2341 tgtggcacac ctgtacaccg gaaaaattga ataccaggtc ggaagatagc agtggcgcca
     2401 ttttgcagcc tagttgtcag ccaggcatgt attcatctct gtatggggta aaagaaaaga
     2461 acagcagcat cgtttttacg accactgctg atactattat tactgagatc ataatataat
     2521 tatccatgaa aattttatta gtacaccaat actttttgga agaagatgat cccggaggtt
     2581 cccgatggaa tgagatcacc aaatcctgga cagagcaagg cgccgaagta acggtgttag
     2641 gcggcatgat gcactacaac ggctccgcta aaagagaaga gtacaagggg aaatactttg
     2701 tgaagaagca acagggcgcc atcaccgtat ggcgctgtca tgtgtcggaa tcttacaacg
     2761 ctaattttct cggcaggttg tggggatatt tctcgttcat gttttcttcc ctctgggcag
     2821 gcctctttaa ggtaaaaggt aagtttgatg tagtagtagt tacttctccg ccattattcg
     2881 taggcttttc aggatacctg ttgtccaggc taaagagaat gccattggta tttgaagtac
     2941 gtgacctctg gccggagtcg gccatcgaca cgggcgtact gaagaataaa ctcgtgatca
     3001 aactggctta ttgggtagag gattttattt atcggaaggc agccatgatc aatgtattga
     3061 cgccggcttt ctataatacc ctgcgcgaca aaaagaacgt accggagcaa aaactcatct
     3121 ttattcccaa tgcggcagat ttctccttgt cggatcacct gctggagtcg ttcgaccggg
     3181 acagcttccg ccgtgagcac cagttgagcg acaaattcgt gattacctat gtgggagcac
     3241 atggcgtggc caatcacctg gagcaagtgc tggatgccgg caaagcattg gaagatacac
     3301 ctgtgttatt cctgttgatc gggcagggga tggaaaagcc ccggttacag cagctcgcgg
     3361 cagaaaaagg cgtgaagaat gtacgcttcc tggatgctgt tcccaaggca gatgtattta
     3421 aatatatcct ggcttctgaa atgggcgctt ctatactgaa gaaagtagac acctttaaaa
     3481 cggtgtactc caataaaaca ttcgactaca tggcttgccg taagcctatc cttatggcga
     3541 tcgacggggt gtcgagagag ctggtggaaa cagcaggagc aggttgttac gtggagcctg
     3601 agaatacagc cgcttacaac acgattatcc ggcagtacct gaaagatccg cagcgcctgc
     3661 aaacggaagg cgatagcggc ttccgttatg cgaagcagaa tttcgaccgc caggtattgg
     3721 catcccgata cctggatttt atcaggaaaa aaatcactaa agaaataaaa gcaaacaatg
     3781 cactggtaca ggaacctgtt taaaccgctg atggatatca cagcagcact gttggcattg
     3841 gtgatattgt cgcccgtgat gttgatactg gtgttgctat tggccatcgc taacaatggc
     3901 cgccctttct ttttgcaacc tcgtccgggt aaaaacggac ggatattccg tgttattaag
     3961 ttcaaaacaa tgaacgaccg gaaagacgca aatggccggc tactgcccga tgaagtgagg
     4021 ctgacaccgg tgggaaagtt cgtccggaaa acatcactgg atgaaattcc ccagctgatc
     4081 aatgtgttaa aaggagatat gagcctggta ggtccccgtc ctttactggt agattatctc
     4141 ccgttgtaca acgatacgca gcatcgccgt catgaagtgc ggccggggat tacgggctgg
     4201 gcacaggtga atggccgtaa tgccatcagc tgggaacaga agtttgcata tgacgtatgg
     4261 tacgtaaaca atatcagctt tgccctggat ctcaaaataa tccggatgac gctacaaaaa
     4321 gtgattaagt cagaggggat caatgcggca ggcgttgcta ccatggagcg ttttatggga
     4381 aatggatgac tgcattaaat aataaagtat gtatttattt ggcgccggtg ggcatgcaaa
     4441 agtgattatc gaaatactgc aatccgggaa ggttccagtg gaggggctat ttgacggcaa
     4501 tcccgacctg aagcaggttt ggcaatatcc ggtaatagct tattcacctg aaatgccggt
     4561 tgcagcaatt attatagcga ttggaaagaa cgctgtccgg aaaaatatcg cggaacaatt
     4621 atccattcct ttcggcactg cgctgcatga aagagctaat atctctccct ctgcgatgat
     4681 agcagaagga accgtgatca tggcgggagc tacggtaaat gcagatgtat tagtgggtaa
     4741 acattgcatt attaacacca atgcttcggt cgaccacgac tgtgtgttgg aagattttgt
     4801 gcacatatct cctaatgccg cactatgtgg taatgtaaaa gtaggagaag gcgcgcacat
     4861 cggtgcgggt gcagtggtga ttcccggtat cactattggc aaatgggccg ttattggcgc
     4921 aggagccgtt gttactaaag atattcctga tcatagcgta gcagtaggaa accctgcacg
     4981 taaaagataa acctaaaaaa ttaccatgat gaataagaaa atatggttat cctcccctca
     5041 tatgggaaca aaggagttag aatttataaa agacgcattt gatactaact ggattgcacc
     5101 attagggcct catgtggatg gttttgaaag agatttgtca acatataccg gtgctgctca
     5161 tgtggcggca ttgtcgtcgg gaacggcagc cctgcacctg gcattgatta cagtgggagt
     5221 agcgccgggt gatgaagtca tctgccagag catgaccttc tctgcttccg ccaatccaat
     5281 agcctacctg ggcgctacac ctgtttttgt agacagtgaa acgtccacct ggaacatgga
     5341 ccctgcattg ctggaacagg caataataga tcgaatcgaa aatggcaaaa agcccaaggc
     5401 aatcattcct gttcatttgt acggcatgcc ggcacaaatg aatgagatca tggcaatcgc
     5461 caaccgttat gagattcccg ttattgaaga tgcagccgag gcgttgggct cctggtaccg
     5521 ggagcaagcc tgtggtagca tcggtaaact aggtatactc agtttcaacg gtaacaagat
     5581 cattactacc agtggaggag gtgcattaat aagtaatgag gaagcgctta tcagtcactc
     5641 ccgcttcctg gccacacagg cacgtgatgc tgctccccac taccagcata gccatatcgg
     5701 ctataactac cgtatgagca atgtttgcgc gggtattggc cgtggacaaa tgctggtgct
     5761 ggaagaaagg gcagcacaac gcagggcaaa ctaccggcat tacgtggcac agttatctga
     5821 tttgccaggc gttacttttg tatcagagcc cgtaggtttc tttagcaacc gctggctctc
     5881 cactatcctg gtaaacccgg cgcagagcaa tggtattacc cgtgaaacta tacgcctggc
     5941 gctggataga gagaacattg aatccagacc actttggaaa cccatgcata tgcagcccgt
     6001 ttttgagaaa atgccggcct atgtaaacgg tgtttccgaa aaactgtttg acaacggatt
     6061 atgtctgcca agtggatcca atctcacgcc ggcagacctt tggcgcgtta cggacgtaat
     6121 caggggattg tttgccgccg caaaagtaaa tgcttcccgt acgtatcagt cacaagacta
     6181 aatggatacc agaggttacg cttattttat tttcttgcct gaaaagaaaa taagtgtagc
     6241 cttctcctgt tatcccaccc tataaacccg atcaacgatg acaccactgc tgttgaaata
     6301 ttccgatgct ttgtccggtg tatctaaaca ccttgcagca gtattgtttt ttatcataag
     6361 tgccttgcat cccgttaccg cacaggatat tttgctgaaa aacccttccc tggaaggaac
     6421 accgggaaaa gataaagtac ccgatttatg gaaaccaaga aacaccccgg atgtacaacc
     6481 cggcacattc gatattaatc tgccaccttc caacggcgcc acctatgtag gtatgcatag
     6541 tggtcctgcc tacctggaag ccattagcca ggaggtatca ctgatcggtg gcaaaaccta
     6601 tacaatagca ctggacctgg cttatgctac taaatattct tcgctcacct gttatggtaa
     6661 tcttacggta tatggcggca atacgcccac tgatacagca gaaaggctat ggagctccgg
     6721 cgcatttaca catacgagct ggaagcgcta ctcctttact ttccatcctt cccgcagtta
     6781 taagtttatc accttcatgg ccgatgccac gattccctgc gataaaagta tttatggttc
     6841 cgctgtgttg atggacaacc tgtcggctgc attgctggaa acaccccagc tcacgctgtc
     6901 gctgaaaaat acctgtaagg gagaacatac cggggaggct accgttactg ttacgggcgt
     6961 atctgccacc tgtgctatcc gctggagccg tgcaggagaa accacgtcgc gcatcacagg
     7021 tttggagccc ggcgattacg atgttacagt aacacatccc aatggcgtaa gcgttacgca
     7081 acacttcacc attataggct gggaagtaaa aagcaagatc acggtgacgc catcccgctg
     7141 ttacgggcag cacaacagca ccattgcact ggaaaccaca ggcggtactc caccttaccg
     7201 gtattatttc aatggtagca ccaccggtac ttatacggct tctttcgaaa aattatctcc
     7261 cggaaattac agtatccgga taaaagatga agaaaactgc gcagagcaga ttgacaatat
     7321 ttccgtagtg gaacctgccc ccctggcgat tgctggcata cgcaaaaaag atatcagctg
     7381 cgctaccact ttcgatggga agattgcgtt gaatgttacc ggcggtacac agccttatac
     7441 atatagtctc gataacgggc tttggcagcc ggatagcagc tggggaggac tagatgccgg
     7501 caacttccat ttcaggatca aagacgcaca tgactgtgaa acagatgggc aggcagacat
     7561 tatccgcaat aaccgcgagt gtgccgtgtt tgtacccact gcgtttacgc ccaatggcga
     7621 cgggttaaat gacctgttcc gcgcaaaggt acacgatgac gtacacgatt accatttgga
     7681 agtatacacc cgctggggac aaacggtatt tagcactaat gatccggaag gtgtgtggga
     7741 tggcacgttt aaaggaaatc cattaccggg aggaagttat gtatggatgt tgttgtatac
     7801 cgatagtaag caacaggcac gtaaacaaac cggcacggta acgcttataa agtagcgtta
     7861 ccgaaaggat acgtatccag cagtttccgc agcttgttgt ttttagcgat gccggtaata
     7921 gcttgaagat gtttttcgtg gtgcagatca gtaccaataa gatcaggtaa accggctgcc
     7981 atcagctttt ccgccgcttg ttgcacatgc ttgccataat acccggtcag cgacagcagg
     8041 ttaagctgaa gcaggcagcc ttgttttttc agttgttcat atttgacgat gtctgcatga
     8101 taataggcat atctttccgg atgcgcgagt acaggctgat acccggcggc ctgtatatca
     8161 aataaccact gcgccagctg caaaggaggc gagatgaaag aaatttccac cagtacctta
     8221 ttgcccgaca gtgtcagcag gggctgttgg agcagtgttt caaactgttc gtccatataa
     8281 tactcagctg cataatgaaa tggaatcgta ttgtttttcc gggcaagcgc ttccaccact
     8341 tcctggtagg gtgctgcaat agtagcggcg gagttgggat aacggtccat cataatatgt
     8401 ggagtggtca caattttctg gatccccata tgttgtagct gctctataaa cgccattgct
     8461 gtagctacat ccggcactcc gtcgtcaata ccaggaatga gatgcgaatg tatatctgtg
     8521 cccatgaagg ccagcagctg tgccggcact gcctgatcgg tatttcgttt acggaaaaaa
     8581 agcatacttg tctttaaggc gatgaagtaa tttttcgctc tcctatatca caatcagtgc
     8641 cacaatttct tccaggtacc gctgatctgt ttcatcaaaa tgagataagg attcgctatc
     8701 tacgtccaac acagctttta cctcgttgtt gcggatcagt gggaccacga tctctgattt
     8761 ggataggctg ctgcaggcga tatgtcccgg gaaggcttcc acatcaggta caattagtgt
     8821 agtagcctgt gcccagctgg taccacatac gcctttgttc ttacggatac gtgtacacgc
     8881 tattggtccc tgaaaggggc ctaatactaa ttcttctccc ttaacgagat aaaatcctac
     8941 ccaaaaccag ccgaattgct ctttcaaagc tgctgctaca ttggccaggt tggccaccag
     9001 gtctggctct ccgtccaata gccccttgat ttgcgggatc agggagcgat attgttcttc
     9061 tttgtttccc tgtacaacat gtaagtcttc tgccataatc attgctgtta atagcgcaaa
     9121 aatccggaaa ttttatatta tattagctga ataaccgtta aagtatttat tgttaaccat
     9181 tcaaccggta aaatttgtat gaagcattgt tttttgccag ttcatcctat tttccgtctg
     9241 ccggaagctt aattaaaata tctttgtcaa tgctatgaaa tcaccggacg taattttagt
     9301 gaacgaaaaa gatgaggcta ttggtactat ggaaaagatg gaagcacacc agaaaggggt
     9361 gttgcaccgt gcattttctg tatttattat aaatgatgcc ggagagctgc tattgcagcg
     9421 cagggcgctg gaaaagtacc attctgcagg gttatggacc aacgcctgtt gcagtcacca
     9481 gtttcccggt gaaactaccg ccgcagcagc gcaccgccgt ttgcaggaag aaatgggatt
     9541 cgactgcgaa ttgcatgaaa tctttgcctt tacgtataaa tcggaatttg ataatgggtt
     9601 aaccgaacat gaattcgacc acgtattgct gggcgtttat aatggtaaca tatctcccaa
     9661 cgcggcagaa gtatgtgatt accgttacct gcccacaggt cagatcctcg aattaataaa
     9721 gaacgagccc gacaccttta ctatctggtt ccataaggca ctgcctattg tattggaaca
     9781 tatgaagatc ccgagcgttg gataaaattt tatttagcta tgccaatttg ctgttaaccg
     9841 gattgcttta aggaaataaa ttaccgcacc tacctgattt agccgcttca tgtggcctgc
     9901 tttggcgtgc ctgtcacaac tatattatgc catataccca tatggctatc cctatctcat
     9961 tttcaaccct ctattaattc actatttaaa cgcaattctc atgacaacca ttcaaatgcc
    10021 aacaatcagt tatcccttta cttcgggcgt aaaccaccat gtaaatgaag cccagcaaca
    10081 cattaccaac tgggtgcaaa cccacgggct tattacttcc gccacggccc tgaaacgctt
    10141 tgagaaagcc cgtttcgcat ggctggcagg aagagccttc cccgatgcgg cgctgcatga
    10201 attatgcatt atcgccgatt ttaacacctg gctctttatt ttagatgatc aatgcgatga
    10261 ggctgccgtt ggccgcaaag ccgactacct caaaagcgtg atggccggcc tgatggatat
    10321 cttgcaaacc aaccagaccg ttacactggc cagcggcggc ccgctggctg ccggtcttag
    10381 cagcatatgg gaccgtatgc gcgctatcag ctcacccgcc tggcgtttgc ggtttatccg
    10441 cagtatgcag gattacttta tgtcctgtat ctgggaggcg gaaaaccggg aagccggtcg
    10501 ggtcccctct gtagaagact atatccatat gcgcccgtac acaggcgccc tcctggcgga
    10561 catagaagca atagaaatca tcgaaaaaat ctatctccca cgcccggtag tggaacaagc
    10621 cctgttgcaa cgtatgatcc aggcctgtaa taacgtcgta tgctggtcga acgacctttt
    10681 ctcctgtact aaggaatccc gccagggcga cgtgcacaat ctcgtgctgg tactgcaaca
    10741 ccagcggcag atttccctgc aggaagccgt taaccaggcc gcccgcatgc acaatgaaga
    10801 agtagccata ttcgtggccc tggaaaaact gttgcccctg aaaggcgatg aaacagatta
    10861 tgaattgctc cggtatgtag cagtactacg ctcgtggatg gtaggcaact tcgactggag
    10921 tgtgaaagat accggtaggt atggactgga acaacaagcc atagtcgccg cataagtcaa
    10981 cggcccccgg cattttccac caaacttccc gggggccatt tttaactacg ctttatccgc
    11041 ttttcgatca accgccccac ccaccagaac gaaagcgcca ggataccaaa gaaaagaccc
    11101 ttattggtat ggtcccagag atattcgaaa taacgggtat acaggtccaa caggagaaag
    11161 atcacgccca ggtcgcgcaa caaatcatct tttactctga tgcctagtaa tatcatgccc
    11221 acacattgaa gactgtacac aatcacccat tgcaacaggt ggatctgccg taactgttgc
    11281 cattcttccc aggtgccgca attaccaaag atagaaatca accaaccgga aataatgaac
    11341 aacaaccatc cgccggtcca gctgatattc ttgataggcg catatacctg gagttggcgc
    11401 aatccccagg ccatccctat cagcaaaacc cctagtaaag ccatgcggca gggaaggttc
    11461 atacccagga aaaaagccgc gtcgccggtc agatagtaag tgagctttac ataagccggc
    11521 accaggcata ataatgtggc tatccacatc agccgtgaac gcagggcaat gcccagcacg
    11581 ccataacaaa cggtagccag caaccagaaa accccataat tgccttccag gtattgcagg
    11641 ctctttccca ggtataccac gcttacgcct atactgagta caggcaggag ccagaaaagc
    11701 tcccggttaa aggaaaacaa cggctggtgc cggttacgcc gccacccctc gtaacaaagg
    11761 aaaatactga cggcagcaaa cagcacggca atgaccccat cggtcatgga aaatttcttc
    11821 cggataatct ctatccattt ctcatccaac acgagcgaac cgaaggccat caatgcacag
    11881 gatacggcgg caataaaaat atacagggta agcgtttgcc agtcggtact caccacctta
    11941 taactttgcc gcaaccggct ggcctgctcg gtggtgagca gctgttcctg ctcccattga
    12001 tggatggccc gctgcagtac ctgggcttcc cgcttatcta gtgttaacat aggcgatatt
    12061 ttcagctgtg tggtcctatt ttatgtacca atcgaagcgt attacgtttt tttatcttta
    12121 aacggaaatg gttaaacaaa gccagcgccg gaatagccat ataactgata cgttggtacg
    12181 cagtattgtc ggggtacagg aaataggtca tggcaatcac cgtgaaaccc gttgccatgg
    12241 taagaaaacc gtattttaag cgctggtata gcagtgtttt ctctgtatga tgtccctctg
    12301 tcgctaaatc cgggtttttc tggaaaataa agtaactgat ccagaacaac gccgccaggc
    12361 atcctgtgag gttacacagg taaataaaga aaggcagcat aaaatgactg ctggtatgca
    12421 ggagcgcgga ggtagaaaac ggaaataaca caataaaaaa caaaaagaaa agatgccggt
    12481 gtatcaatcc ttcgttgtaa ttttggagca accggcatag ttgcaggtgc cgtacccaaa
    12541 aattaccaat aaatataaaa cttactgcaa aagctagtaa ttcaaaggct gtaggccgca
    12601 ttaactccca atagtcacga tcgacaggca ttttaaccgg aagagcgggc agtttgattt
    12661 cgatgaccag taacgcaata gcaacggcaa acaccatatc acagaaaaaa ataagtcgct
    12721 ccagctcaaa cacacgatgt aaaggtttgg gttctttgat aacagacata gacatagtta
    12781 acaatatact tttccgaaag atacgaaaat agcttttagc agcctgtaat cgtgctttcc
    12841 acctgcccgg ataatccctt ttatccccgc acaacctttt tacatgttta ttgttaagta
    12901 tctatcaatc atcatatact ttcaaagtaa taagtatgcg ttgtcgttat attctattca
    12961 ccctactttt atggacccaa acaactatcg cttacgggca ggtggatacc tcacggtctg
    13021 gtaattatga ctttaacctg gccaattgca tacaatacgg cctcgcacat cagaacgatg
    13081 tagttaatgc caggctggat gtaaactttt cccaggaaca gattaaagaa tacacaggga
    13141 aatttttgcc ccacgtaaat gtgaacgcta gtattactga caacctcaaa ctccagacct
    13201 ccttaattcc cgacattgcc aacgggaact acgataagaa aataccggtg caattcggca
    13261 ccaaatgggc gtctgccgcc acaggacagg tggaccaggt gatattcaac agcgattact
    13321 tcctgggcct taaagcttcc cgggtgtatg gagatctctc taaaaagacg ctcaaacgta
    13381 cggaaataga tacccgggta gccattacca aagcctacta tgccgccctc gccgcagaag
    13441 aaaatatccg gctggcaaag tctaacatga cccaactctc caaaacactg gcagatacca
    13501 aagcccggta cgacgtgggc gtagccgaaa gggtagatgt agaccgtatc caggtgtctt
    13561 ataataatat tgtgacggat attgaaaccc agatcaggga tctcgtatat gcgatgcagt
    13621 tattgaaatt ccagatgggc atgccgcagg agaacaaatt gaccctcacc gaaacggtac
    13681 aggacctcaa tgcagatgtt tttatcgcag atacagtcga ttaccaggtg caagaccgca
    13741 ttgaatacag catgcaaact acccaggtaa cgctggatga gctgagcctg aaaagtaaaa
    13801 aactgggcat cctcccccaa ctgaatgcct atgtgaatta tggatataac tatttctcta
    13861 ctaagttcag cgacctgtat aaaaccggct acggcgcctc tgcactgggg ctcaccctga
    13921 aatggcccat ttttgcagga acagaacggt atcaccagat ccaggaaaac aggattacgc
    13981 tggagaagtc gagaaataca ctacaataca tcggtgaaca aatacagctg gatgtggcca
    14041 atgccaatac ccagtaccag aataacaaat caaggtatgt aacacagaaa accaatatgg
    14101 acttaaccca gggcatatac gaccgtattg tgctcaagtt tgaacaggga gtggctacca
    14161 gcctggatgt tacctcagca gaaaatgacc tgaaacaggc gcaggtgaat tatgtgcagg
    14221 cgctgctgaa tacactgacc agtaaaacag acctggacaa agccatgggc aagatcaaat
    14281 aagctattat tcgtaattcg caattaattt ctcatatgta tccagtcaat tacaagcgga
    14341 cattttatgt ggcaggaatg atgctctgtg tggcctgtgg taacagcaaa aagcaacaac
    14401 aacagcaggc cgctatgatg gggaagatga aacctacggt agtagccgtg gaagtaacgc
    14461 ctgcttccta caccgtcgcc gaaaaatttc ccgccaccct ggtggcccac gacgtggtat
    14521 cccttcgccc cgatgttacc ggctacctgg aagcgatccg tgtgccagac ggcagtagtg
    14581 taaccaaggg ccagcccctg tatgatattg acagaagccg ctatgccgcg gcctatggcc
    14641 aggtagcggc ctcccaggaa caggccgaag ccgacctggc gcagaaaacg agggattatg
    14701 aaagatataa atcgctgctc gaacatgatg ctatctccaa acaaacggta gaccaggcca
    14761 acacagccat gctcaccgcc aaagccaacc ttaccgccgc caaagctgcc gtggcaaaag
    14821 ccggtacaga cgtaagccat gcggtggtaa aagcacccgt gaccgggaaa ataggcatcg
    14881 cccaaattaa agtcggcgat atcgtcaacg ccggtcaaac actcatcaat accatcgtca
    14941 acgaacaccc gatgtttgcc gatatggata ttccacagtc ccgcctgccg gaattccagc
    15001 ggatgcagaa aggacagggc gaccataaat tctttatcca gtttggcgac ggtacccgct
    15061 atggggaaga aggaaaaata ctgaccatca ataatattgt agatcctcaa accggtactg
    15121 tccgggtgcg gctcgtattc cagaatagcg atggcatgct gaaatcagga atgagcatcg
    15181 tagccgtgat gcagtatggc acaccgggta cccagctggc tattcctgcc aaagcgatta
    15241 tccagaatct ttctgaaacc agcgtgtata cgctcagcaa agataatgtg gttgccgcga
    15301 gggatattat acctggcccc gttaccgata ccatgctgct ggttaccagc gggttaaatg
    15361 ccggcgatag gatagtagtg gaagggttac aacgggtaaa acccggagat accgtgaata
    15421 ttgccggacc cggcgccgca cctggcacag ctcccggggc aggtaaacat taatcctaaa
    15481 tcactctcag ggtatgatct caaaaacatt tatagagcgc aagaatacta cgatcgtcat
    15541 tgccatcatc attgtgattg taggactcat ctgcatgttt aacctgccca tcgcccagct
    15601 gccggatatt gcaccaccgg taacggatgt acgggccaac tatgtaggag ccaactccac
    15661 cacggtagag gaaacagtga ccacccccat agaaaaccag gtaaacggta ctcccggcgc
    15721 catgtatatc cagtcggtaa gcgctaacga tggatctatg agtatcacgg tcacctttaa
    15781 actgggcacc aaccccgata tctccaccct cgacgtacaa aacagggtga gcctggcttt
    15841 gcccagtacg cccgatgaag taaggcgtgt gggcgttacc gttaaaaagc gctccaatga
    15901 tatgttgatg gtaatcgcgc tcaactctcc caaaggaaag cacagccgcg aattcctcga
    15961 taactacctg aatatttacc tgaaaccgga actggcccgt atcagtggag tgggcgacgt
    16021 aaatgccttc tcccaggact atagtatgcg tatctggctc aacccggata agatggccgc
    16081 cctgggtctc accgccggcg atatttcccg cgctatcacc gaacaaaacc aacaggtacc
    16141 ggccggtagt gtgggcgccc cacccatggg caggtcacag gcatttgaat acaccgtgag
    16201 cgtgaaagga cgcctggcca cttcggaaga attcggtaat gtagtggtag ctaccagccc
    16261 caatggcggc ctggtacgcc tccgcgacgt ggcgcgtatc gacctgggct cctttaccta
    16321 cgccattgaa gccaaagccg acggtaaaac cggtagcggg atggccatct acctgtcgcc
    16381 cggtgccaac gccctcgacg taaacgaccg ggtgatcgcc aaaatgaagg atatggccaa
    16441 aagcttcccc gacgacgtaa actggctcat cccctttgaa acaacctcct tcgtaaaaat
    16501 atcgatcgat gaagtaatac aaacatttat agaagccctc gtgctcgtgg tcattgtggt
    16561 gtttgtgttc ctgcagaact ggcgggccac cctgattccc atcctggtaa tccccatctc
    16621 tttgattggt acctttatct ttttccagct gctgggcttc tctatcaata cactcaccct
    16681 cttcgggttt gtgctggcca tcggtattgt ggtggatgat gccattgtag tggtggaggc
    16741 ggtgcagcac catatcgatg ccgacctcat gtcgccccgc gaggccacct tcaaagccat
    16801 ggcagaagtg agcgccccgg taatcgccat cgcgctgatc ctggcggcag tgttcgtacc
    16861 agtggccttt atcccgggcg taagcggaag gctgtaccaa cagtttgcgt taaccatcgc
    16921 cttctcagta ttattgtcgg ccttcctggc gctgacgctc acgccggcac tgacagccat
    16981 tttgctcagg cccgcacacc tcaccaaaca atcgcacgga ctcaataaac tcttctttaa
    17041 attcaacgaa tggtttggcc ggtttaccaa tcgttatggg aatggcgtaa aacattccat
    17101 ccgctttacg cccgcggtgc tgatcatcct gggagtattg tttgctatcg ccgctttcct
    17161 gtttaagaaa acgccgacca ccttcgtacc ccaggaagat atgggcgccc tgttcatcgc
    17221 attggaattg ccggaagcct cctctacaga acgcaccaaa gaggtggtag cagaaatcag
    17281 caatatcctc acaaaagaca gtgccgtaag tcattttttt gggatcaccg gtatcaactt
    17341 tgtggccaac gctaccaaac ctaactccgg tacctttttc gtgagcctca aaccctggga
    17401 cgaacgatat gcccacggcg acaatatcaa taccgtatta ggacgtatac agggcgctgc
    17461 cggccgcatt attggggcca acgtcatctg tatcccggcg cccaccctgc gtggattggg
    17521 tacttccggc ggtttctcct tcatcctcga acaacgtagc aacccggata tcaatcaatt
    17581 cctccaggtg atgggccagt tcctgatggc cgccaatcaa cggccggaaa ttgcgcgggc
    17641 gtatgctttc ttcagtgcta acacaccaca gttcaacgtg gaagtagacc gtgataaatg
    17701 caagcagctc ggcgtagccg tgagtgatgt tttcaatgcg ttgcaaacat tcctcggggg
    17761 actttacgtc aacgatttca ctaaattcag tcgcagcttc cgcgtagtgc tgcaagccga
    17821 ttcgttgtac cgcaccagta tcaataacct gaatacttat tatgtaagga ataataacgg
    17881 gcaaatggtg ccgctcagcg cattgatcac cactaaaaaa tctgccggtg ccccggtaat
    17941 caaccacttt aacctgtacc ggtctgtgga aatcgatggg gatagtaaaa ccggctacag
    18001 tagtggcgac gccatcaacg cactaaagga agtagccgct tctgtattac ctgaaaactt
    18061 cagctacgaa tgggccaacg tatccctgca ggaaattgaa gcaggtaata gtagcctgct
    18121 gatctttggc ctatctattc tctttgtatt cctgttgctc acagccctgt atgaaagctg
    18181 gtcggtgcca ttttctgtac tgctggcagt gccggtagcc ctgttcggat ctatcgtggc
    18241 attgtcgctt accaaacagg ctaatagcgt atattcgcag ataggcctga ttaccctgat
    18301 aggtttggct gctaaaaatg ccatcctgat cgtggagttc tgtaaggaac gtgtggatag
    18361 gggaatgccc ttgctggaag ccacactgga agcggtgaaa ctgcggttac gccccatcct
    18421 gatgacttcc ttcgcattca tcctcggcgt attgcccttg tgcctggcta aaggcgctgg
    18481 tgccgcgtcc cgtgttaata taggcttcac cgtagtagga gggatgctgg cagcaacatt
    18541 gctggggatc ttcaccgtac cggtattata tgtactgatc accaagctgg cctacggtaa
    18601 gaaaaaactg gccgagctgg aagcacatgg taatgaagag aaaaaaccta aaggtttagg
    18661 cgaataaccg taacaggatg aaaaatacag aacgtttcag tacccgcgta gaaaactatg
    18721 tcaaataccg gccgcattac ccggcggcta tcattcctta cctggctaag gaagcaggat
    18781 tgacccgcga caccgtagtg gcagatattg gcgccggtac cggcatttcc gcacagcctt
    18841 tcctggataa tggtaacaag gtatatgccg tggagcccaa tacagaaatg cgggaaatgg
    18901 cggaaaaact cctgcaccgg tatccgggtt tccagtcagt agccggcagc gcagagtata
    18961 ccacgctgcc cgacaactca atagagctta tcctggcagg tacggccttt cactggtttg
    19021 atcaatccgc cacagcggcc gaattccagc gcatcggcaa agataatgcg gtcattgtgc
    19081 taatgtggaa tgtacggcaa tctgaacttc cctttgagaa aagctacgaa aagctgctac
    19141 accaatatgg aactgattat aaggaattgc agcacaggaa cgtaggtgcg tcgcagttag
    19201 cctccttttt tgcgcccgct gctattcatg aaacgtcatt ccagaatgcg cagatcttcg
    19261 attttgccgc gctgaaagga cgtatgcttt cctcttccta cgttccggaa aaagatcacc
    19321 cttcctatcc cgctatgatg aaggacctgg aagatatttt ctggaaatac caggaacagg
    19381 gtatggtgaa gtttcactat gaaacgaagt tgtattgggg aagaattttg aagaaataaa
    19441 caggaaatat ataaaaagca agcaggggaa taacacgtta ttcccctgct tgctttttat
    19501 attatatcga taattacttg agactgttat acaatatctc taccgggtgc agcgctttaa
    19561 cgccggtacc atcttttacc tggtggcggc agctggtgcc tggcgccgca atcagcgtac
    19621 ctgcggcggc attgcgtacc gcggggaaca ataccatctc gccaatctgc atgctcaggt
    19681 cataatgttc ggtttcatat ccgaaagatc ctgccatacc gcagcaaccg gaagggatca
    19741 cttctacggt gtagtttttc ggcagcgaca acatcttctt gctatgcagg gcagatgaca
    19801 acgctttctg ctggcaatgt ccgtgtaatt tgatatgttg aggggcatcg gtaaactgat
    19861 ccgcactgat atgccctttc tctgcttcgg ccgccaggaa ttcatctacc aggaatacgt
    19921 gtttggctaa tgtttttgcg gtggcgcgca gctcttctct taccaggtcg gggtactcat
    19981 cccggaagct caggatggca gagggttcta ttcccaatag cgggacgttt tcattgataa
    20041 cgtcgctgaa tatacgaaca ttcttttcgg catactcgcg ggcctggcgt aacaatccct
    20101 tcgacatata ggcgcgggca ctttccgggt gctcaatcat ttgtacgtcg taacccagcc
    20161 ggtgcaggag cgctacggct ttgataccaa tagtggtatc gttatagttg gtgaattcgt
    20221 cgcaaaaaag atacactttc cgttgaccgg ccgcagctcc ctgtttttcg agcggccatt
    20281 tttctttgaa ccatttccgc agcgtcgtcg tgtgtaagcc gggcagggaa cgtttggccg
    20341 caaagccgga aaacttccgg atgatgccac cggtaaagga attgttgatc accgcattgt
    20401 acatgccggg agcaatagct gccagcgccg ataacttcga atagttaccg atcatccgcg
    20461 cacgcaatgg caccccattg gcatcgtagt agtgctgcag gaattccatt ttcagtttgg
    20521 ccatatccac gttggatggg cattcggact tacaaccctt gcaagccagg cagaggtcca
    20581 gcacttcgta aatttcttta tggtcgaaac ggttttcttt ggtgctatgg gtgaggaatt
    20641 cacgcaggat attagccctg gcgcgggtag tatctttttc attccgggtg gccatatagc
    20701 tggggcacat ggtaccaccg ctcaactgcg ttttgcggca gtcgccggag ccattacact
    20761 gctccgcatg ttgcagcatg gtttgatccg gaaagtggaa gatcgttttg atatccggtg
    20821 ctttttgtcc tggttcgtac cggagcatac tgttcataga tggcgtgtct acgatcttat
    20881 ggggattgaa gatattctct gggtcccagg tatacttgat ctggcgaagc agttcatagt
    20941 tcttgctgcc caccatctgt ttgataaact cgccc
//
