GCF_012726265.1 - 28 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAASAG010000001.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-ii,other	343,539	407,660	Medium	birimositide	ribosomal:RiPP:Lanthipeptide

NZ_JAASAG010000010.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	aminopolycarboxylic-acid	225,068	238,623	High	Ethylenediaminesuccinic acid hydroxyarginine	other:other
Region 2.2	terpene	253,730	274,833

NZ_JAASAG010000011.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	terpene	92,627	114,684

NZ_JAASAG010000013.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	NRPS-like	62,893	106,024	Low	lipstatin	NRPS:Type I

NZ_JAASAG010000014.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	NRPS,T1PKS	1	34,406
Region 6.2	linaridin	49,384	70,073	Low	TVA-YJ-2	ribosomal:RiPP

NZ_JAASAG010000015.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	NI-siderophore	1	17,553	High	legonoxamine A/desferrioxamine B/legonoxamine B	other:other

NZ_JAASAG010000017.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	T1PKS	1	90,364	Low	natamycin	PKS

NZ_JAASAG010000018.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	T1PKS	1	53,477	Low	sceliphrolactam	PKS

NZ_JAASAG010000019.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	NRPS-like,T1PKS	1	25,500	Medium	nystatin A1	PKS:Type I+saccharide:hybrid/tailoring
Region 11.2	butyrolactone	38,094	49,209

NZ_JAASAG010000002.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	butyrolactone	180,776	191,783

NZ_JAASAG010000020.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	T1PKS	32,359	60,958	Low	nystatin-like Pseudonocardia polyene A1	PKS

NZ_JAASAG010000024.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	T1PKS	1	17,331	Low	gargantulide B/gargantulide C	PKS

NZ_JAASAG010000026.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	T1PKS	1	7,375

NZ_JAASAG010000028.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	T1PKS	1	3,090

NZ_JAASAG010000029.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	T1PKS	1	2,809

NZ_JAASAG010000003.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 23.1	terpene	469,191	495,798	Medium	hopene	terpene
Region 23.2	T1PKS	787,239	821,818	Low	pentamycin	PKS

NZ_JAASAG010000004.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 27.1	t3nrps-iterative,NRP-metallophore,NI-siderophore,NRPS,terpene-precursor	71,195	208,400	Low	peucechelin	NRPS:Type I

NZ_JAASAG010000005.1 (Streptomyces sp. HNM0575)

Region	Type	From	To
Region 28.1	NI-siderophore	49,656	82,987
Region 28.2	hglE-KS	196,834	249,138
Region 28.3	RiPP-like	450,679	462,094

NZ_JAASAG010000006.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 29.1	RiPP-like,terpene,NRPS-like,T2PKS	255,370	351,898	High	kinanthraquinone B/kinanthraquinone	PKS
Region 29.2	NRPS-like,T1PKS	390,658	437,033	Medium	amipurimycin	PKS+NRPS:Type I+saccharide

NZ_JAASAG010000007.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 30.1	ectoine	367,885	378,289	High	ectoine	other:ectoine

NZ_JAASAG010000009.1 (Streptomyces sp. HNM0575)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 32.1	RiPP-like	277,620	288,426

No secondary metabolite regions were found in these records:: NZ_JAASAG010000012.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000016.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000021.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000022.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000023.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000025.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000027.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000030.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000031.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000032.1 (Streptomyces sp. HNM0575); NZ_JAASAG010000008.1 (Streptomyces sp. HNM0575)

Compact view

NZ_JAASAG010000001.1 - Region 1 - lanthipeptide-class-ii,other

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Location: 343,539 - 407,660 nt. (total: 64,122 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

HCC61_RS01490: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

HCC61_RS01630: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HCC61_RS01650: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

HCC61_RS01660: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

HCC61_RS01665: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: cyclase

HCC61_RS01470: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

HCC61_RS01480: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000555.3	0.34	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000520.5	0.29	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0001210.5	0.28	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002346.3	0.28	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0002663.2	0.27	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0001787.3	0.27	ribosomal	suicin 3908	Streptococcus suis
BGC0002573.2	0.26	other (other)	phosphoramidon	Streptomyces mozunensis
BGC0000498.5	0.25	ribosomal	bovicin HJ50	Streptococcus equinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.80	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.76	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.62	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0002573.2	0.59	other (other)	phosphoramidon	Streptomyces mozunensis
BGC0000516.4	0.55	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000555.3	0.55	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002663.2	0.53	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for HCC61_RS01470

HCC61_RS30395

Leader:

MYKGDVSLVEEIAEQDFEGVAYGA

Core:

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDALDhbNDhbGGWCysDhbLDhbVECysQPNCysN

antiSMASH-DB 4.0 matches for HCC61_RS30395

100.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

96.7%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide

Lanthipeptides: K378_RS05175_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDALTN GGWCTLTVECQPNCN

1

CTTNTFSLSDALTNQGGWCTLTVECQPNCN

30

93.3%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L NTGGWCTLTVECQPNCN

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

with 98 more sequence matches

Only the first 10 are displayed here.

90.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDAL N+GGWCTLT ECQPNCN

1

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

30

86.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDAL N GGWCTLT ECQ NCN

1

CTTNTFSLSDALGNHGGWCTLTKECQANCN

30

86.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDA+ N GGWCTLT ECQPNCN

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

30

86.7%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDAL N GGWCTLT ECQPNC+

1

CTTNTFSLSDALGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L N GGWCTLT ECQPNCN

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

30

83.3%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

C+TNTFSLSD L N GGWCTLT ECQPNCN

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

83.3%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSD+L N GGWCTLT ECQPNC+

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNCS

30

80.0%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNC

29

CTTNTF+LS+ L N GGWCTLTVECQPNC

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNC

29

76.7%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTF+LSD L N GGWCTLT ECQ +CN

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

73.3%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTF+LS+ L N GGWCTLT ECQ +CN

1

CTTNTFTLSNYLGNNGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for HCC61_RS30395

86.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLS+AL N GGWCTLT ECQPNCN

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

46.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDALTNTGGWCTLTVECQPNCN

30

+++S L N G +CTLTVEC P+CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

25.6%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTVECQPNCN

30

CTL+ ECQPNCN

28

CTLSKECQPNCN

39

HCC61_RS01465

Leader:

MSEDILGG

Core:

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

Core with dehydrations:

YDEDELVELDhaDADDhbYGGDhbGPWCysVADhbVDhbLADhbAAICysPDhbDhbKCysDhbDhaQCys

antiSMASH-DB 4.0 matches for HCC61_RS01465

100.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

95.3%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE ELVELSDADTYGGTGPWC+ATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADTYGGTGPWCIATVTLATAAICPTTKCTSQC

43

86.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE ELVELSDAD YGGT W ATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

with 110 more sequence matches

Only the first 10 are displayed here.

76.7%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide

Lanthipeptides: OGH68_RS19755_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+ADTYGGT WC+ATVTL +AA+CPTTKCTS C

1

YDEAELIELSEADTYGGTAAWCIATVTLVSAAMCPTTKCTSAC

43

76.7%

NZ_GG657757.1and 1 other:

NZ_GG657757.1 Lanthipeptides: SSQG_RS41860_lanthipeptide

Lanthipeptides: SSQG_RS41860_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD +GGTGPWC+ATVTL TA +CPTTKCTS+C

1

YDEAELIELSEADNHGGTGPWCIATVTLVTATVCPTTKCTSKC

43

76.7%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide

Lanthipeptides: IQ62_RS33140_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+ADT+GGTGPWC+ATVTL +A CPTTKCTS C

1

YDEAELIELSEADTHGGTGPWCIATVTLVSAVACPTTKCTSSC

43

60.9%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCV---ATVTLATAAICPTTKCTSQC

43

YDE ELVE+ +AD YGGT C A TL +A+ CPTTKCTSQC

1

YDEFELVEMGEADVYGGTTWSCAIVTAVATLVSASACPTTKCTSQC

46

60.5%

NZ_BNBV01000031.1and 3 others:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide

Lanthipeptides: IE286_RS22990_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD GGT P +A A+AA CPTTKCT+ C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASAAFCPTTKCTNDC

43

60.5%

NZ_CP016795.1and 7 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS37680_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide

Lanthipeptides: BC342_RS37680_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD GGT P VA A+ A CPTTKCT +C

1

YDEAELIELSEADVTGGTTPVSVAVSVAASVAFCPTTKCTKEC

43

58.1%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide

Lanthipeptides: TNCT1_RS35805_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD GGT P +A A+ A CPT KCTS C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASVAFCPTIKCTSAC

43

54.5%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15870_lanthipeptide

Lanthipeptides: IE314_RS15870_lanthipeptide

1

YDEDELVELSDADTYGGT-GPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+EL + +GGT P C+AT + A CPTTKCTS+C

1

YDELELIELGEDVAHGGTTSPVCIATSVAVSTAFCPTTKCTSKC

44

47.8%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide

Lanthipeptides: LHJ74_RS33595_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVAT---VTLATAAICPTTKCTSQC

43

YDE EL+EL+D++ +GGT P ++ +T AT +ICPT+ C+S+C

1

YDEAELIELADSEAFGGTSPATTSSWTCITAATISICPTSACSSKC

46

46.3%

NC_016582.1and 1 other:

NC_016582.1 Lanthipeptides: SBI_RS34370_lanthipeptide

Lanthipeptides: SBI_RS34370_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATV-----------TLATAAICPTTKCTSQC

43

+DE ELVELS+AD +GGT P + +AA CPTTKCTS+C

1

WDEAELVELSEADVHGGTDPAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSRC

54

MIBiG 4.0 matches for HCC61_RS01465

41.9%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

18

TGPWCVATVTLATAAICPTTKCTSQC

43

TGP CVA A+AA CPTTKCTS+C

1

TGPLCVAASVAASAAFCPTTKCTSKC

26

25.6%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

30

TAAICPTTKCTSQC

43

+AA CPTTKCTS+C

24

SAAFCPTTKCTSRC

37

allorf_344422_344553

Leader:

MRSVEPGDACAGRGPAASVTGS

Core:

AGGPVRKAGCQRAGCKRIHTL

Core with dehydrations:

AGGPVRKAGCysQRAGCysKRIHDhbL

antiSMASH-DB 4.0 matches for allorf_344422_344553

100.0%

NZ_JAASAG010000001.1:

Lanthipeptides: allorf_344422_344553_lanthipeptide

1

AGGPVRKAGCQRAGCKRIHTL

21

AGGPVRKAGCQRAGCKRIHTL

1

AGGPVRKAGCQRAGCKRIHTL

21

24.3%

NZ_CP021903.1and 6 others:

NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS09270_lanthipeptideNZ_CP028218.1 Lanthipeptides: C7M30_RS01850_lanthipeptideNZ_CP035167.1 Lanthipeptides: EQJ08_RS08875_lanthipeptideNZ_CP089148.1 Lanthipeptides: LRO88_RS09410_lanthipeptideNZ_JAMYDW010000001.1 Lanthipeptides: NHM07_RS00470_lanthipeptideNZ_JAQOXM010000003.1 Lanthipeptides: PO770_RS15540_lanthipeptide

Lanthipeptides: CD007_RS08815_lanthipeptide

1

AGGPVRKAGCQRAGCKRI

18

+GG KA C RA C I

9

SGGVASKALCSRAMCDGI

26

24.3%

NZ_JAJQVT010000008.1:

Lanthipeptides: PAF28_RS14660_lanthipeptide

2

GGPVRKAGCQRAGCKRI

18

GG KA C RA C I

10

GGVASKALCSRAMCDGI

26

with 1 more sequence matches

14.3%

NZ_KB900614.1:

Lanthipeptides: allorf_2973181_2973414_lanthipeptide

2

GGPVRKAGCQRAGCKRIH

19

P R+AG GC+R+H

11

SAPARRAGWITEGCQRVH

28

allorf_345810_345944

Leader:

MRSIPFRAGPCAARSPAA

Core:

RSPKSPTQLARVGAVFGHCARGLAPL

Core with dehydrations:

RDhaPKDhaPDhbQLARVGAVFGHCysARGLAPL

antiSMASH-DB 4.0 matches for allorf_345810_345944

100.0%

NZ_JAASAG010000001.1:

Lanthipeptides: allorf_345810_345944_lanthipeptide

1

RSPKSPTQLARVGAVFGHCARGLAPL

26

RSPKSPTQLARVGAVFGHCARGLAPL

1

RSPKSPTQLARVGAVFGHCARGLAPL

26

18.2%

NZ_CP077652.1:

Lanthipeptides: allorf_2255880_2256005_lanthipeptide

1

RSPKSPTQ

8

RSP++PTQ

14

RSPRTPTQ

21

11.7%

NZ_PVTF01000002.1:

Lanthipeptides: allorf_797510_797749_lanthipeptide

2

SPKSPTQLARVGA

14

SPK+P+Q+ R G

33

SPKTPSQVGRTGG

45

allorf_346005_346232

Leader:

MVRGGIAQKEALLCGRVTGESGYGHRTCTARFRADNFPPNARSWARRTDSAPAA

Core:

DRARAHHGTSEQACTSWGYRK

Core with dehydrations:

DRARAHHGDhbDhaEQACysDhbDhaWGYRK

antiSMASH-DB 4.0 matches for allorf_346005_346232

100.0%

NZ_JAASAG010000001.1:

Lanthipeptides: allorf_346005_346232_lanthipeptide

1

DRARAHHGTSEQACTSWGYRK

21

DRARAHHGTSEQACTSWGYRK

1

DRARAHHGTSEQACTSWGYRK

21

41.4%

NZ_QLLX01000002.1:

Lanthipeptides: allorf_330819_330977_lanthipeptide

5

AHHG----TSEQACTSWGYRK

21

AH+G TSEQ TSWGY +

9

AHYGLCVHTSEQRRTSWGYLQ

29

33.3%

NZ_CP064192.1:

Lanthipeptides: allorf_6233503_6233592_lanthipeptide

1

DRARAHHGTSE

11

DR R H TSE

2

DRERCHSETSE

12

with 3 more sequence matches

29.0%

NZ_BMUQ01000012.1:

Lanthipeptides: allorf_024174_024338_lanthipeptide

4

RAHHGTSEQACTSWG

18

RA GTS CTS G

3

RAQCGTSRPRCTSRG

17

23.8%

NZ_CM000756.1:

Lanthipeptides: BTHUR0011_RS33055_lanthipeptide

10

SEQACTSWGY

19

S Q C+ +GY

12

SSQLCSCYGY

21

15.6%

NZ_CP070496.1:

Lanthipeptides: allorf_3783783_3783950_lanthipeptide

1

DRARAHHGTSEQACTS

16

++RA H T E C S

12

QQSRAPHSTQESRCVS

27

allorf_346027_346167

Leader:

MQACSEVPWCARARSAAGA

Core:

ESVRRAQERAFGGKLSARNLAVQVRCP

Core with dehydrations:

EDhaVRRAQERAFGGKLDhaARNLAVQVRCysP

antiSMASH-DB 4.0 matches for allorf_346027_346167

100.0%

NZ_JAASAG010000001.1:

Lanthipeptides: allorf_346027_346167_lanthipeptide

1

ESVRRAQERAFGGKLSARNLAVQVRCP

27

ESVRRAQERAFGGKLSARNLAVQVRCP

1

ESVRRAQERAFGGKLSARNLAVQVRCP

27

33.3%

NZ_BMMP01000005.1:

Lanthipeptides: allorf_157781_157972_lanthipeptide

14

KLSARNLAVQVRCP

27

K +ARNLA RCP

1

KSTARNLAGNRRCP

14

23.1%

NZ_CP025249.1:

Lanthipeptides: allorf_0077306_0077500_lanthipeptide

8

ERAFGGKLSARN

19

ERAFGGK+ A N

1

ERAFGGKVGAEN

12

with 1 more sequence matches

20.0%

NZ_LT607733.1:

Lanthipeptides: allorf_2263047_2263265_lanthipeptide

8

ERAFGGKLSARNLAVQVRC

26

+R GGKL A + + RC

21

QRDIGGKLGAAHACGRGRC

39

allorf_352495_352659

Leader:

MPITGAKDRMGG

Core:

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

Core with dehydrations:

KRIRKRGCysGEDGVDhaAAVPRNVDhaPDhaAPFLRDhaGMLRDhaMLKAGLE

antiSMASH-DB 4.0 matches for allorf_352495_352659

100.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: allorf_352495_352659_lanthipeptide

Lanthipeptides: allorf_352495_352659_lanthipeptide

1

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

42

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

1

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

42

19.0%

NZ_BMLN01000009.1:

Lanthipeptides: allorf_125527_125676_lanthipeptide

19

RNVSPSAPFLR

29

RN SPSAP+ R

24

RNPSPSAPYNR

34

14.5%

NZ_JANTYU010000003.1:

Lanthipeptides: allorf_281565_281777_lanthipeptide

7

GCGEDGVSAAVPRN

20

GCG DG + A P N

29

GCGSDGPAPANPAN

42

with 1 more sequence matches

14.3%

NZ_CP023465.1:

Lanthipeptides: allorf_4127819_4127986_lanthipeptide

19

RNVSPSAPFLRSGMLR

34

+ + P PF + G+LR

6

KQIPPGPPFSKGGILR

21

Lanthipeptide(s) for HCC61_RS01480

HCC61_RS30395

Leader:

MYKGDVSLVEEIAEQDFEGVAYGA

Core:

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDALDhbNDhbGGWCysDhbLDhbVECysQPNCysN

antiSMASH-DB 4.0 matches for HCC61_RS30395

100.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

96.7%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide

Lanthipeptides: K378_RS05175_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDALTN GGWCTLTVECQPNCN

1

CTTNTFSLSDALTNQGGWCTLTVECQPNCN

30

93.3%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L NTGGWCTLTVECQPNCN

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

30

with 98 more sequence matches

Only the first 10 are displayed here.

90.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDAL N+GGWCTLT ECQPNCN

1

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

30

86.7%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDAL N GGWCTLT ECQ NCN

1

CTTNTFSLSDALGNHGGWCTLTKECQANCN

30

86.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDA+ N GGWCTLT ECQPNCN

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

30

86.7%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSDAL N GGWCTLT ECQPNC+

1

CTTNTFSLSDALGNHGGWCTLTKECQPNCS

30

86.7%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSD L N GGWCTLT ECQPNCN

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

30

83.3%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

C+TNTFSLSD L N GGWCTLT ECQPNCN

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

30

83.3%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLSD+L N GGWCTLT ECQPNC+

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNCS

30

80.0%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNC

29

CTTNTF+LS+ L N GGWCTLTVECQPNC

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNC

29

76.7%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTF+LSD L N GGWCTLT ECQ +CN

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

30

73.3%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTF+LS+ L N GGWCTLT ECQ +CN

1

CTTNTFTLSNYLGNNGGWCTLTKECQRSCN

30

MIBiG 4.0 matches for HCC61_RS30395

86.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CTTNTFSLSDALTNTGGWCTLTVECQPNCN

30

CTTNTFSLS+AL N GGWCTLT ECQPNCN

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

46.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDALTNTGGWCTLTVECQPNCN

30

+++S L N G +CTLTVEC P+CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

25.6%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTVECQPNCN

30

CTL+ ECQPNCN

28

CTLSKECQPNCN

39

HCC61_RS01465

Leader:

MSEDILGG

Core:

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

Core with dehydrations:

YDEDELVELDhaDADDhbYGGDhbGPWCysVADhbVDhbLADhbAAICysPDhbDhbKCysDhbDhaQCys

antiSMASH-DB 4.0 matches for HCC61_RS01465

100.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

95.3%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE ELVELSDADTYGGTGPWC+ATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADTYGGTGPWCIATVTLATAAICPTTKCTSQC

43

86.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE ELVELSDAD YGGT W ATVTLATAAICPTTKCTSQC

1

YDEAELVELSDADAYGGTA-WVCATVTLATAAICPTTKCTSQC

42

with 110 more sequence matches

Only the first 10 are displayed here.

76.7%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19755_lanthipeptide

Lanthipeptides: OGH68_RS19755_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+ADTYGGT WC+ATVTL +AA+CPTTKCTS C

1

YDEAELIELSEADTYGGTAAWCIATVTLVSAAMCPTTKCTSAC

43

76.7%

NZ_GG657757.1and 1 other:

NZ_GG657757.1 Lanthipeptides: SSQG_RS41860_lanthipeptide

Lanthipeptides: SSQG_RS41860_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD +GGTGPWC+ATVTL TA +CPTTKCTS+C

1

YDEAELIELSEADNHGGTGPWCIATVTLVTATVCPTTKCTSKC

43

76.7%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide

Lanthipeptides: IQ62_RS33140_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+ADT+GGTGPWC+ATVTL +A CPTTKCTS C

1

YDEAELIELSEADTHGGTGPWCIATVTLVSAVACPTTKCTSSC

43

60.9%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCV---ATVTLATAAICPTTKCTSQC

43

YDE ELVE+ +AD YGGT C A TL +A+ CPTTKCTSQC

1

YDEFELVEMGEADVYGGTTWSCAIVTAVATLVSASACPTTKCTSQC

46

60.5%

NZ_BNBV01000031.1and 3 others:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22990_lanthipeptideNZ_BNBV01000031.1 Lanthipeptides: IE286_RS22985_lanthipeptide

Lanthipeptides: IE286_RS22990_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD GGT P +A A+AA CPTTKCT+ C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASAAFCPTTKCTNDC

43

60.5%

NZ_CP016795.1and 7 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS37680_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18955_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS17685_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01490_lanthipeptide

Lanthipeptides: BC342_RS37680_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD GGT P VA A+ A CPTTKCT +C

1

YDEAELIELSEADVTGGTTPVSVAVSVAASVAFCPTTKCTKEC

43

58.1%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS35805_lanthipeptide

Lanthipeptides: TNCT1_RS35805_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+ELS+AD GGT P +A A+ A CPT KCTS C

1

YDEAELIELSEADVTGGTTPVSIAVTVAASVAFCPTIKCTSAC

43

54.5%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15870_lanthipeptide

Lanthipeptides: IE314_RS15870_lanthipeptide

1

YDEDELVELSDADTYGGT-GPWCVATVTLATAAICPTTKCTSQC

43

YDE EL+EL + +GGT P C+AT + A CPTTKCTS+C

1

YDELELIELGEDVAHGGTTSPVCIATSVAVSTAFCPTTKCTSKC

44

47.8%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide

Lanthipeptides: LHJ74_RS33595_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVAT---VTLATAAICPTTKCTSQC

43

YDE EL+EL+D++ +GGT P ++ +T AT +ICPT+ C+S+C

1

YDEAELIELADSEAFGGTSPATTSSWTCITAATISICPTSACSSKC

46

46.3%

NC_016582.1and 1 other:

NC_016582.1 Lanthipeptides: SBI_RS34370_lanthipeptide

Lanthipeptides: SBI_RS34370_lanthipeptide

1

YDEDELVELSDADTYGGTGPWCVATV-----------TLATAAICPTTKCTSQC

43

+DE ELVELS+AD +GGT P + +AA CPTTKCTS+C

1

WDEAELVELSEADVHGGTDPAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSRC

54

MIBiG 4.0 matches for HCC61_RS01465

41.9%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

18

TGPWCVATVTLATAAICPTTKCTSQC

43

TGP CVA A+AA CPTTKCTS+C

1

TGPLCVAASVAASAAFCPTTKCTSKC

26

25.6%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

30

TAAICPTTKCTSQC

43

+AA CPTTKCTS+C

24

SAAFCPTTKCTSRC

37

allorf_352495_352659

Leader:

MPITGAKDRMGG

Core:

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

Core with dehydrations:

KRIRKRGCysGEDGVDhaAAVPRNVDhaPDhaAPFLRDhaGMLRDhaMLKAGLE

antiSMASH-DB 4.0 matches for allorf_352495_352659

100.0%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: allorf_352495_352659_lanthipeptide

Lanthipeptides: allorf_352495_352659_lanthipeptide

1

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

42

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

1

KRIRKRGCGEDGVSAAVPRNVSPSAPFLRSGMLRSMLKAGLE

42

19.0%

NZ_BMLN01000009.1:

Lanthipeptides: allorf_125527_125676_lanthipeptide

19

RNVSPSAPFLR

29

RN SPSAP+ R

24

RNPSPSAPYNR

34

14.5%

NZ_JANTYU010000003.1:

Lanthipeptides: allorf_281565_281777_lanthipeptide

7

GCGEDGVSAAVPRN

20

GCG DG + A P N

29

GCGSDGPAPANPAN

42

with 1 more sequence matches

14.3%

NZ_CP023465.1:

Lanthipeptides: allorf_4127819_4127986_lanthipeptide

19

RNVSPSAPFLRSGMLR

34

+ + P PF + G+LR

6

KQIPPGPPFSKGGILR

21

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.25 out of 23.79

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.36 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.94 out of 20.97

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 34.36 out of 36.53

Confidence: strong

Additional weak hits (26):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.01 out of 20.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.68 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.68 out of 32.74

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.70 out of 21.55

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.49 out of 30.97

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.08 out of 30.22

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.32 out of 20.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.40 out of 21.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.43 out of 23.43

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.37 out of 39.62

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.91 out of 19.26

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.82 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.75 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.39 out of 36.53

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.08 out of 27.18

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.58 out of 20.01

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.73 out of 26.85

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.93 out of 29.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.90 out of 33.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.15 out of 28.19

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.38 out of 23.43

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.29 out of 29.25

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

HCC61_RS30395 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 3031.3 Da

Molecular weight: 3033.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3051.3 Da N = 1; 3069.4 Da N = 2; 3087.4 Da N = 3; 3105.4 Da N = 4; 3123.4 Da N = 5

HCC61_RS01465 - Class II

Cleavage pHMM score: -2.10

RODEO score: 0

Monoisotopic mass: 4318.0 Da

Molecular weight: 4320.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4338.7 Da N = 1; 4356.8 Da N = 2; 4374.8 Da N = 3; 4392.8 Da N = 4; 4410.8 Da N = 5; 4428.8 Da N = 6

allorf_352495_352659 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 4406.4 Da

Molecular weight: 4409.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4427.2 Da N = 1; 4445.2 Da N = 2; 4463.2 Da N = 3; 4481.2 Da N = 4

HCC61_RS30395 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 3031.3 Da

Molecular weight: 3033.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3051.3 Da N = 1; 3069.4 Da N = 2; 3087.4 Da N = 3; 3105.4 Da N = 4; 3123.4 Da N = 5

HCC61_RS01465 - Class II

Cleavage pHMM score: -2.10

RODEO score: 0

Monoisotopic mass: 4318.0 Da

Molecular weight: 4320.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4338.7 Da N = 1; 4356.8 Da N = 2; 4374.8 Da N = 3; 4392.8 Da N = 4; 4410.8 Da N = 5; 4428.8 Da N = 6

allorf_344422_344553 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 2160.2 Da

Molecular weight: 2161.6 Da

Number of bridges: 1

allorf_345810_345944 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 2634.5 Da

Molecular weight: 2636.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2654.1 Da N = 1; 2672.1 Da N = 2

allorf_346005_346232 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 2344.1 Da

Molecular weight: 2345.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2363.5 Da N = 1; 2381.5 Da N = 2; 2399.6 Da N = 3

allorf_346027_346167 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 2961.6 Da

Molecular weight: 2963.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2981.4 Da N = 1

allorf_352495_352659 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 4406.4 Da

Molecular weight: 4409.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4427.2 Da N = 1; 4445.2 Da N = 2; 4463.2 Da N = 3; 4481.2 Da N = 4

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism
MexT	Global virulence regulator

NZ_JAASAG010000010.1 - Region 1 - aminopolycarboxylic-acid

Download region GenBank file

Download region SVG

Location: 225,068 - 238,623 nt. (total: 13,556 nt) Show pHMM detection rules used

aminopolycarboxylic-acid: (AesA and AesB and AesC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

HCC61_RS23440: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Hydrolases: deaminase

HCC61_RS23460: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase

HCC61_RS23455: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase

HCC61_RS23450: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001587.5	0.71	other (other)	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002568.2	0.69	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0002567.2	0.58	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0000563.4	0.43	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001634.3	0.41	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001779.5	0.41	ribosomal	siamycin	Streptomyces nodosus
BGC0001655.3	0.41	ribosomal	LP2006	Nocardiopsis alba DSM 43377
BGC0000575.5	0.41	ribosomal	lariatin	Rhodococcus jostii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001587.5	0.71	other (other)	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002568.2	0.69	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0002567.2	0.58	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0000563.4	0.43	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001229.4	0.41	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001634.3	0.41	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001779.5	0.41	ribosomal	siamycin	Streptomyces nodosus
BGC0001655.3	0.41	ribosomal	LP2006	Nocardiopsis alba DSM 43377
BGC0000575.5	0.41	ribosomal	lariatin	Rhodococcus jostii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 31.03 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.03 out of 36.53

Confidence: medium

Additional weak hits (1):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.99 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor

NZ_JAASAG010000010.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 253,730 - 274,833 nt. (total: 21,104 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HCC61_RS23585: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS23595: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

HCC61_RS23600: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

HCC61_RS23550: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: cyclase

HCC61_RS23590: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002043.3	0.54	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001911.3	0.47	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.46	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001483.4	0.46	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000677.5	0.46	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000902.4	0.45	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0002445.3	0.45	terpene	armillyl orsellinate, 8α-hydroxy-6-protoilludene	Armillaria gallica
BGC0002643.2	0.43	other (other)	aetokthonotoxin	Aetokthonos hydrillicola Thurmond2011
BGC0001197.5	0.43	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002043.3	0.54	ribosomal	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001911.3	0.47	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.46	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001483.4	0.46	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0000677.5	0.46	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000902.4	0.45	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0002445.3	0.45	terpene	armillyl orsellinate, 8α-hydroxy-6-protoilludene	Armillaria gallica
BGC0002643.2	0.43	other (other)	aetokthonotoxin	Aetokthonos hydrillicola Thurmond2011
BGC0001197.5	0.43	PKS	frankiamicin	Frankia sp. EAN1pec

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

HCC61_RS23590: T1TS

Domain 1 (7 - 311): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 27.49 out of 30.12

Confidence: strong

Additional weak hits (10):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.10 out of 30.25

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.61 out of 29.51

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.76 out of 29.65

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.45 out of 25.75

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.83 out of 33.14

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.21 out of 20.01

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.01 out of 23.43

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.25 out of 27.04

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.06 out of 27.55

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.33 out of 20.01

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
OsdR	Development and stress management regulator

NZ_JAASAG010000011.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 92,627 - 114,684 nt. (total: 22,058 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

HCC61_RS24400: dioxygenase, TauD/TfdA

smcogs: SMCOG1121: dioxygenase, TauD/TfdA

HCC61_RS24440: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase sulfotransferase

HCC61_RS24395: Sulfotransferase domain

extras: Sulfotransfer_3: Sulfotransferase domain

HCC61_RS24420: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

HCC61_RS24435: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002007.2	0.51	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0000632.5	0.47	saccharide, terpene	brasilicardin A	Nocardia terpenica
BGC0001206.5	0.43	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0002019.3	0.42	terpene	tiancilactone A, tiancilactone B, tiancilactone C, tiancilactone D, tiancilactone E, tiancilactone F, tiancilactone G, tiancilactone H	Streptomyces sp. CB03234
BGC0002128.3	0.41	other (other)	5-dimethylallylindole-3-acetonitrile	Streptomyces coelicolor A3(2)
BGC0002554.2	0.41	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0000815.4	0.41	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0002218.2	0.41	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0001903.3	0.41	other (other)	neocarazostatin A	Streptomyces sp. MA37
BGC0002584.2	0.40	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002007.2	0.51	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0000632.5	0.47	saccharide, terpene	brasilicardin A	Nocardia terpenica
BGC0001206.5	0.43	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0002019.3	0.42	terpene	tiancilactone A, tiancilactone B, tiancilactone C, tiancilactone D, tiancilactone E, tiancilactone F, tiancilactone G, tiancilactone H	Streptomyces sp. CB03234
BGC0002128.3	0.41	other (other)	5-dimethylallylindole-3-acetonitrile	Streptomyces coelicolor A3(2)
BGC0002554.2	0.41	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0000815.4	0.41	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0002218.2	0.41	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0001903.3	0.41	other (other)	neocarazostatin A	Streptomyces sp. MA37
BGC0002584.2	0.40	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

HCC61_RS24410: T2TS

Domain 1 (88 - 598): Type 2 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (3):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_JAASAG010000013.1 - Region 1 - NRPS-like

Download region GenBank file

Download region SVG

Location: 62,893 - 106,024 nt. (total: 43,132 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

HCC61_RS26900: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

HCC61_RS26970: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

HCC61_RS26975: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

HCC61_RS26980: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

Transferases: acetyltransferase

HCC61_RS26880: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: protease

HCC61_RS26950: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: dehydratase

HCC61_RS26925: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

HCC61_RS26920: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HCC61_RS26930: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HCC61_RS26935: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

HCC61_RS26940: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.70	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002286.3	0.62	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001833.4	0.60	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001825.4	0.59	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.70	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002286.3	0.62	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001833.4	0.60	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001825.4	0.59	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.23 out of 29.72

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.76 out of 23.79

Confidence: medium

Additional weak hits (12):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.24 out of 26.12

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.43 out of 36.54

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.94 out of 33.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.50 out of 30.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.51 out of 30.98

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.81 out of 28.14

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.47 out of 35.63

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.57 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.41 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.58 out of 28.19

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.20 out of 30.11

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 62892 - 106024:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Asn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS26920: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (427..817): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWATFDLTGTTLKLVVGGEVNEYGPTEAAIGCVV
Nearest Stachelhaus code(s):: Asn DLTKVGEVGK (82% 8Å match); OH-Asn or Asn DLTKVGEVGK (79% 8Å match); Asp DLTKVGHIGK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

HCC61_RS26930: X

AMP-binding (18..457): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MGIL----LYGDFAVSGGAHTTYGATEALPITSI
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
NtrC	Nitrogen regulatory protein C

NZ_JAASAG010000014.1 - Region 1 - NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 34,406 nt. (total: 34,406 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

HCC61_RS27290: aminotransferase

smcogs: SMCOG1019: aminotransferase

HCC61_RS27345: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Ligases: ligase synthase

HCC61_RS27275: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HCC61_RS27280: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.66	NRPS	peramine	Epichloe festucae
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (6):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.40 out of 18.57

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.73 out of 28.19

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.89 out of 23.43

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.45 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.69 out of 29.38

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 34406:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Phe - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS27275: mal

PKS_AT (1065..1353): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 89.0
inactive: 41.0
Methylmalonyl-CoA: 37.2
Methoxymalonyl-CoA: 33.0
2-Methylbutyryl-CoA: 19.3
Propionyl-CoA: 18.0
CHC-CoA: 18.0
Benzoyl-CoA: 11.8
Ethylmalonyl-CoA: 11.5
Isobutyryl-CoA: 10.9
trans-1,2-CPDA: 9.9
fatty_acid: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

HCC61_RS27280: Phe - X

Search NORINE for peptide: strict or relaxed

AMP-binding (29..504): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LESAFDAAVLETYIIVAVEINGYGPTEAAVCVSM
Nearest Stachelhaus code(s):: Phe DAWTIAGVCK (59% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1236..1624): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGAAFDLVTFDGDMIVGGEINAYGPTEATTYATY
Nearest Stachelhaus code(s):: Val DAFWIGATFK (59% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
MexT	Global virulence regulator

NZ_JAASAG010000014.1 - Region 2 - linaridin

Download region GenBank file

Download region SVG

Location: 49,384 - 70,073 nt. (total: 20,690 nt) Show pHMM detection rules used

linaridin: (cypemycin or cypI)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HCC61_RS27445: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: methyltransferase

HCC61_RS27455: methyltransferase

smcogs: SMCOG1248: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.5	0.53	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001188.3	0.49	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0001226.4	0.43	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002669.2	0.42	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0000501.3	0.41	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001579.4	0.41	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000496.5	0.40	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001735.5	0.53	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001188.3	0.49	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0001226.4	0.43	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002669.2	0.42	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0000501.3	0.41	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001579.4	0.41	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000496.5	0.40	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.40 out of 27.55

Confidence: medium

Additional weak hits (5):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.51 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.91 out of 27.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.18 out of 29.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 30.25

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 16.96 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
RpoN	Regulator of nitrogen assimilation and virulence

NZ_JAASAG010000015.1 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 1 - 17,553 nt. (total: 17,553 nt) Show pHMM detection rules used

Region on contig edge.

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HCC61_RS27860: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Lyases: decarboxylase

HCC61_RS27865: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.79	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000941.3	0.79	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.5	0.71	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002073.3	0.59	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002690.2	0.57	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.79	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000941.3	0.79	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.5	0.71	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.61	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002073.3	0.59	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002690.2	0.57	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.16 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53

Confidence: medium

Additional weak hits (6):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.37 out of 36.54

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.78 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.35 out of 26.06

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.82 out of 32.93

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.41 out of 36.53

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.92 out of 27.04

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor

NZ_JAASAG010000017.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 90,364 nt. (total: 90,364 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

HCC61_RS28735: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

HCC61_RS28760: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

HCC61_RS28765: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS28775: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: esterase

HCC61_RS28740: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

HCC61_RS28745: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

HCC61_RS28730: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HCC61_RS28770: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.73	PKS	asperlactone	Aspergillus ochraceus
BGC0000041.3	0.58	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.56	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000016.4	0.53	other (other)	amphotericin B	Streptomyces nodosus
BGC0000551.5	0.50	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001310.5	0.50	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000844.5	0.50	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000126.5	0.50	PKS	pladienolide B	Streptomyces platensis
BGC0001012.3	0.50	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0000353.5	0.50	NRPS	tacrolimus	Streptomyces sp. MA6548

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.73	PKS	asperlactone	Aspergillus ochraceus
BGC0000041.3	0.58	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.56	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000016.4	0.53	other (other)	amphotericin B	Streptomyces nodosus
BGC0000551.5	0.50	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001310.5	0.50	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000844.5	0.50	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000126.5	0.50	PKS	pladienolide B	Streptomyces platensis
BGC0001012.3	0.50	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0000353.5	0.50	NRPS	tacrolimus	Streptomyces sp. MA6548

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.45 out of 30.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 90364:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ccmal - ccmal - ccmal - ccmal - ccmal) + (ccmal - ohmal - Me-ohmal - ohmal - ohmal - ohmal) + (ccmal - ohmal - redmal)
Non-colinear ordering:: HCC61_RS28730 + HCC61_RS28770 + HCC61_RS28775

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS28730: mal - mal - mal - mal - mal - mal

PKS_AT (553..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.1
inactive: 104.2
Methoxymalonyl-CoA: 58.7
Methylmalonyl-CoA: 49.7
Isobutyryl-CoA: 33.3
Ethylmalonyl-CoA: 22.8
Propionyl-CoA: 22.1
Benzoyl-CoA: 19.2
Acetyl-CoA: 15.6
CHC-CoA: 10.4
fatty_acid: 10.1
trans-1,2-CPDA: 8.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2277..2554): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 223.0
inactive: 102.1
Methoxymalonyl-CoA: 64.2
Methylmalonyl-CoA: 59.7
Isobutyryl-CoA: 32.6
Propionyl-CoA: 28.6
Ethylmalonyl-CoA: 28.4
Acetyl-CoA: 19.7
Benzoyl-CoA: 15.9
trans-1,2-CPDA: 13.9
fatty_acid: 10.0
2-Methylbutyryl-CoA: 9.3
CHC-CoA: 7.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3965..4242): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.6
inactive: 102.4
Methoxymalonyl-CoA: 64.6
Methylmalonyl-CoA: 57.4
Isobutyryl-CoA: 31.6
Propionyl-CoA: 28.7
Ethylmalonyl-CoA: 25.6
Benzoyl-CoA: 20.9
trans-1,2-CPDA: 18.6
Acetyl-CoA: 17.7
fatty_acid: 15.1
CHC-CoA: 10.7
2-Methylbutyryl-CoA: 7.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (5665..5942): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.5
inactive: 102.8
Methoxymalonyl-CoA: 65.3
Methylmalonyl-CoA: 60.1
Isobutyryl-CoA: 33.4
Ethylmalonyl-CoA: 27.1
Propionyl-CoA: 24.2
Benzoyl-CoA: 22.7
Acetyl-CoA: 19.5
trans-1,2-CPDA: 15.7
fatty_acid: 13.4
CHC-CoA: 11.7
2-Methylbutyryl-CoA: 6.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (7372..7649): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 217.8
inactive: 103.8
Methoxymalonyl-CoA: 65.5
Methylmalonyl-CoA: 57.4
Isobutyryl-CoA: 31.1
Ethylmalonyl-CoA: 24.8
Propionyl-CoA: 22.8
Benzoyl-CoA: 21.7
Acetyl-CoA: 19.1
trans-1,2-CPDA: 17.1
fatty_acid: 14.0
CHC-CoA: 11.4
2-Methylbutyryl-CoA: 6.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (9065..9342): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.1
inactive: 102.9
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 58.3
Isobutyryl-CoA: 32.3
Ethylmalonyl-CoA: 32.2
Propionyl-CoA: 26.9
Benzoyl-CoA: 23.9
Acetyl-CoA: 17.9
trans-1,2-CPDA: 16.5
fatty_acid: 13.9
CHC-CoA: 13.4
2-Methylbutyryl-CoA: 1.5
3-Methylbutyryl-CoA: 0.0

HCC61_RS28770: mal - mal - mmal - mal - mal - mal

PKS_AT (558..855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.9
inactive: 96.1
Methoxymalonyl-CoA: 68.8
Methylmalonyl-CoA: 51.6
Isobutyryl-CoA: 33.8
Ethylmalonyl-CoA: 29.9
Benzoyl-CoA: 23.0
Propionyl-CoA: 22.1
Acetyl-CoA: 17.9
CHC-CoA: 8.3
fatty_acid: 4.6
trans-1,2-CPDA: 4.1
3-Methylbutyryl-CoA: 2.5
2-Methylbutyryl-CoA: -1.4

PKS_AT (2306..2596): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.7
inactive: 95.1
Methoxymalonyl-CoA: 58.6
Methylmalonyl-CoA: 47.9
Propionyl-CoA: 22.1
Acetyl-CoA: 20.1
fatty_acid: 15.5
Benzoyl-CoA: 12.6
Isobutyryl-CoA: 11.7
Ethylmalonyl-CoA: 11.3
CHC-CoA: 10.4
trans-1,2-CPDA: 8.5
2-Methylbutyryl-CoA: 7.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (3906..4204): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 219.2
Ethylmalonyl-CoA: 208.8
Methoxymalonyl-CoA: 172.7
2-Methylbutyryl-CoA: 138.8
trans-1,2-CPDA: 125.4
CHC-CoA: 108.0
Propionyl-CoA: 102.6
Malonyl-CoA: 95.3
Isobutyryl-CoA: 80.7
Benzoyl-CoA: 68.4
Acetyl-CoA: 31.9
fatty_acid: 29.7
3-Methylbutyryl-CoA: 26.5
inactive: 18.2

PKS_AT (5480..5763): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.2
inactive: 94.6
Methoxymalonyl-CoA: 66.4
Methylmalonyl-CoA: 64.0
Propionyl-CoA: 31.3
Isobutyryl-CoA: 29.0
Ethylmalonyl-CoA: 20.9
Acetyl-CoA: 17.8
Benzoyl-CoA: 14.1
2-Methylbutyryl-CoA: 13.7
fatty_acid: 13.4
trans-1,2-CPDA: 6.9
3-Methylbutyryl-CoA: 5.2
CHC-CoA: 3.7

PKS_AT (6988..7269): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 90.1
Methoxymalonyl-CoA: 66.1
Methylmalonyl-CoA: 62.2
Propionyl-CoA: 30.5
Isobutyryl-CoA: 26.7
Ethylmalonyl-CoA: 20.9
Acetyl-CoA: 17.4
fatty_acid: 14.4
Benzoyl-CoA: 14.0
2-Methylbutyryl-CoA: 13.4
trans-1,2-CPDA: 7.0
3-Methylbutyryl-CoA: 6.2
CHC-CoA: 4.0

PKS_AT (8506..8786): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.4
inactive: 96.6
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 58.8
Isobutyryl-CoA: 37.1
Propionyl-CoA: 20.5
Ethylmalonyl-CoA: 18.3
Benzoyl-CoA: 15.4
Acetyl-CoA: 14.7
fatty_acid: 10.5
CHC-CoA: 7.3
trans-1,2-CPDA: 6.3
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -2.8

HCC61_RS28775: mal - mal - mal - mal

PKS_AT (610..894): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.0
inactive: 86.9
Methoxymalonyl-CoA: 56.1
Methylmalonyl-CoA: 47.4
Isobutyryl-CoA: 26.2
Propionyl-CoA: 25.3
Acetyl-CoA: 19.0
Ethylmalonyl-CoA: 16.1
fatty_acid: 8.1
Benzoyl-CoA: 7.4
CHC-CoA: 2.0
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2383..2669): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.3
inactive: 99.8
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 54.1
Propionyl-CoA: 30.3
Isobutyryl-CoA: 26.1
Ethylmalonyl-CoA: 21.0
Acetyl-CoA: 19.5
Benzoyl-CoA: 19.1
CHC-CoA: 13.9
fatty_acid: 13.2
2-Methylbutyryl-CoA: 9.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3881..4163): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.2
inactive: 96.1
Methoxymalonyl-CoA: 55.0
Methylmalonyl-CoA: 44.5
Propionyl-CoA: 24.9
Isobutyryl-CoA: 21.5
Acetyl-CoA: 15.4
fatty_acid: 13.3
Benzoyl-CoA: 12.3
Ethylmalonyl-CoA: 11.6
CHC-CoA: 7.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (5905..6106): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 157.2
inactive: 71.5
Methoxymalonyl-CoA: 46.9
Methylmalonyl-CoA: 40.9
Ethylmalonyl-CoA: 21.2
Acetyl-CoA: 18.4
Isobutyryl-CoA: 15.5
Propionyl-CoA: 13.7
Benzoyl-CoA: 13.6
fatty_acid: 11.0
CHC-CoA: 9.4
trans-1,2-CPDA: 9.2
2-Methylbutyryl-CoA: 2.3
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

NZ_JAASAG010000018.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 53,477 nt. (total: 53,477 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HCC61_RS28785: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS28815: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS28820: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS31370: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Lyases: decarboxylase

HCC61_RS28840: putative carboxymuconolactone decarboxylase

smcogs: SMCOG1298: putative carboxymuconolactone decarboxylase

Ligases: synthase

HCC61_RS28790: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

HCC61_RS28795: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HCC61_RS28800: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HCC61_RS28805: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

HCC61_RS28835: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.72	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.74	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.74	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.72	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47

Confidence: medium

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.35 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.14 out of 30.22

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.77 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.40 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.03 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.79 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.96 out of 26.33

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 53477:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (redmal) + (Me-mal - Me-ccmal) + (ccmal) + (Me-redmal)
Non-colinear ordering:: HCC61_RS28790 + HCC61_RS28795 + HCC61_RS28800 + HCC61_RS28805

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS28790: mal

PKS_AT (549..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.8
inactive: 75.5
Methoxymalonyl-CoA: 63.6
Methylmalonyl-CoA: 61.8
Ethylmalonyl-CoA: 36.6
Propionyl-CoA: 35.2
Isobutyryl-CoA: 28.5
Acetyl-CoA: 25.6
fatty_acid: 16.0
Benzoyl-CoA: 15.2
2-Methylbutyryl-CoA: 13.5
CHC-CoA: 13.0
trans-1,2-CPDA: 7.2
3-Methylbutyryl-CoA: 0.0

HCC61_RS28795: mmal - mmal

PKS_AT (568..865): mmal

ATSignature: Ethylmalonyl-CoA, Methoxymalonyl-CoA, Methylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 165.5
Ethylmalonyl-CoA: 164.8
Methoxymalonyl-CoA: 150.4
trans-1,2-CPDA: 115.7
Malonyl-CoA: 113.5
2-Methylbutyryl-CoA: 109.6
CHC-CoA: 86.9
Propionyl-CoA: 85.4
Isobutyryl-CoA: 72.8
Acetyl-CoA: 64.7
3-Methylbutyryl-CoA: 51.5
Benzoyl-CoA: 50.4
fatty_acid: 32.9
inactive: 26.7

PKS_AT (2241..2538): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.9
Ethylmalonyl-CoA: 185.8
Methoxymalonyl-CoA: 160.5
2-Methylbutyryl-CoA: 156.4
Propionyl-CoA: 118.4
trans-1,2-CPDA: 107.5
Malonyl-CoA: 95.9
CHC-CoA: 87.5
Isobutyryl-CoA: 56.8
3-Methylbutyryl-CoA: 47.8
Benzoyl-CoA: 46.9
Acetyl-CoA: 41.1
fatty_acid: 39.7
inactive: 33.3

HCC61_RS28800: mal

PKS_AT (592..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.7
inactive: 88.0
Methoxymalonyl-CoA: 54.4
Methylmalonyl-CoA: 43.4
Isobutyryl-CoA: 23.8
Propionyl-CoA: 22.8
Acetyl-CoA: 10.5
Benzoyl-CoA: 10.1
Ethylmalonyl-CoA: 3.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

HCC61_RS28805: mmal

PKS_AT (583..877): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.0
Ethylmalonyl-CoA: 184.7
Methoxymalonyl-CoA: 159.9
2-Methylbutyryl-CoA: 133.6
Propionyl-CoA: 103.7
trans-1,2-CPDA: 94.3
Malonyl-CoA: 91.8
CHC-CoA: 80.6
Benzoyl-CoA: 65.9
Isobutyryl-CoA: 61.9
Acetyl-CoA: 52.1
3-Methylbutyryl-CoA: 43.8
fatty_acid: 27.0
inactive: 21.3

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAASAG010000019.1 - Region 1 - NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 25,500 nt. (total: 25,500 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene overview

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HCC61_RS28970: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HCC61_RS28990: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase glycosyltransferase

HCC61_RS28980: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

HCC61_RS28985: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.61	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.60	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.59	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.58	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.57	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.56	PKS	ACT-Toxin II	Alternaria alternata
BGC0001160.5	0.56	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002154.2	0.54	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.54	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.62	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002154.2	0.61	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.60	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (6):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.93 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.61 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.02 out of 29.38

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.68 out of 21.55

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.33 out of 32.93

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.14 out of 21.84

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 25500:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (AHBA)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS28955: AHBA - mal

CAL_domain (34..448): AHBA

minowa: AHBA

Prediction, score:

AHBA: 386.4
shikimic_acid: 283.8
Acetyl-CoA: 10.6
fatty_acid: 0.0
NH2: 0.0

PKS_AT (1631..1832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 161.5
inactive: 71.0
Methoxymalonyl-CoA: 44.2
Methylmalonyl-CoA: 40.4
Acetyl-CoA: 17.3
Ethylmalonyl-CoA: 16.0
Isobutyryl-CoA: 14.8
Propionyl-CoA: 12.8
Benzoyl-CoA: 12.1
fatty_acid: 7.4
2-Methylbutyryl-CoA: 7.3
CHC-CoA: 5.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAASAG010000019.1 - Region 2 - butyrolactone

Download region GenBank file

Download region SVG

Location: 38,094 - 49,209 nt. (total: 11,116 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

HCC61_RS29085: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000850.5	0.64	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0000849.4	0.59	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0002578.2	0.41	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000914.5	0.26	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000826.5	0.26	other (other)	staurosporine	Streptomyces clavuligerus ATCC 27064
BGC0000827.3	0.25	other (other)	staurosporine	Salinispora arenicola CNS-205
BGC0001771.4	0.25	NRPS	scleric acid	Streptomyces sclerotialus
BGC0001137.5	0.25	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0001083.5	0.25	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0002652.2	0.25	other (other), saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000850.5	0.64	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0000849.4	0.59	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0002578.2	0.41	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000914.5	0.26	other (other)	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000826.5	0.26	other (other)	staurosporine	Streptomyces clavuligerus ATCC 27064
BGC0000827.3	0.25	other (other)	staurosporine	Salinispora arenicola CNS-205
BGC0001771.4	0.25	NRPS	scleric acid	Streptomyces sclerotialus
BGC0001137.5	0.25	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0001083.5	0.25	PKS, terpene	merochlorin A, merochlorin B, deschloro-merochlorin A, deschloro-merochlorin B, isochloro-merochlorin B, dichloro-merochlorin B, merochlorin D, merochlorin C	Streptomyces sp. CNH189
BGC0002652.2	0.25	other (other), saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (6):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.41 out of 26.33

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.89 out of 23.43

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.62 out of 39.62

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.71 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.78 out of 30.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JAASAG010000002.1 - Region 1 - butyrolactone

Download region GenBank file

Download region SVG

Location: 180,776 - 191,783 nt. (total: 11,008 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HCC61_RS04720: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS04725: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: methyltransferase

HCC61_RS04685: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002449.2	0.41	other (other)	sarasinoside	uncultured bacterium
BGC0001223.5	0.40	other (other)	hydroxysporine	uncultured bacterium
BGC0001605.3	0.39	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001458.4	0.39	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440
BGC0001335.5	0.37	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0001483.4	0.36	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0002578.2	0.36	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000968.5	0.35	NRPS, PKS	chaetoglobosin A, chaetoglobosin C	Penicillium expansum
BGC0000665.5	0.34	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000391.5	0.34	NRPS	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002449.2	0.41	other (other)	sarasinoside	uncultured bacterium
BGC0001223.5	0.40	other (other)	hydroxysporine	uncultured bacterium
BGC0001605.3	0.39	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001458.4	0.39	other (aminocoumarin)	salinipostin G, Salinipostin G, Salinipostin A, Salinipostin B, Salinipostin C, Salinipostin D, Salinipostin E, Salinipostin F, Salinipostin H, Salinipostin I, Salinipostin J, Salinipostin K	Salinispora tropica CNB-440
BGC0001335.5	0.37	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0001483.4	0.36	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0002578.2	0.36	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000968.5	0.35	NRPS, PKS	chaetoglobosin A, chaetoglobosin C	Penicillium expansum
BGC0000665.5	0.34	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000391.5	0.34	NRPS	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

Additional weak hits (4):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.96 out of 26.33

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.05 out of 30.22

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.76 out of 21.84

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.19 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MexT	Global virulence regulator

NZ_JAASAG010000020.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 32,359 - 60,958 nt. (total: 28,600 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

HCC61_RS29395: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

HCC61_RS29415: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HCC61_RS29435: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HCC61_RS29445: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS29455: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase transferase

HCC61_RS29425: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

HCC61_RS29440: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Ligases: synthase

HCC61_RS29450: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001275.3	0.62	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001275.3	0.62	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.93 out of 26.85

Confidence: medium

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 32358 - 60958:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS29450: mal

PKS_AT (546..821): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.2
inactive: 78.4
Methoxymalonyl-CoA: 57.5
Methylmalonyl-CoA: 40.8
Propionyl-CoA: 23.6
Isobutyryl-CoA: 11.5
Benzoyl-CoA: 10.8
Acetyl-CoA: 9.8
CHC-CoA: 8.4
Ethylmalonyl-CoA: 7.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JAASAG010000024.1 - Region 1 - T1PKS

Download region GenBank file

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Location: 1 - 17,331 nt. (total: 17,331 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acylase

HCC61_RS31115: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.73	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.73	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.73	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001298.4	0.57	PKS	4-Z-annimycin, 4-E-annimycin	Streptomyces calvus
BGC0000038.5	0.51	PKS	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0000143.5	0.51	PKS	salinomycin	Streptomyces albus
BGC0002229.2	0.51	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0000067.5	0.51	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001065.5	0.50	PKS	herboxidiene	Streptomyces chromofuscus
BGC0001052.5	0.50	NRPS, PKS	tirandamycin	Streptomyces sp. 307-9

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.73	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.73	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.73	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001298.4	0.57	PKS	4-Z-annimycin, 4-E-annimycin	Streptomyces calvus
BGC0000038.5	0.51	PKS	coelimycin P1	Streptomyces coelicolor A3(2)
BGC0000143.5	0.51	PKS	salinomycin	Streptomyces albus
BGC0002229.2	0.51	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0000067.5	0.51	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001065.5	0.50	PKS	herboxidiene	Streptomyces chromofuscus
BGC0001052.5	0.50	NRPS, PKS	tirandamycin	Streptomyces sp. 307-9

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 17331:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ccmal - Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS31115: mal - mal - mmal

PKS_AT (563..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.9
inactive: 102.3
Methoxymalonyl-CoA: 62.4
Methylmalonyl-CoA: 52.2
Isobutyryl-CoA: 28.5
Propionyl-CoA: 26.4
Ethylmalonyl-CoA: 23.8
Benzoyl-CoA: 21.5
Acetyl-CoA: 18.8
trans-1,2-CPDA: 17.0
fatty_acid: 13.4
CHC-CoA: 9.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.4

PKS_AT (2273..2558): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.8
inactive: 105.2
Methoxymalonyl-CoA: 64.4
Methylmalonyl-CoA: 56.1
Isobutyryl-CoA: 33.6
Propionyl-CoA: 27.1
Ethylmalonyl-CoA: 25.7
Benzoyl-CoA: 24.5
trans-1,2-CPDA: 19.4
Acetyl-CoA: 16.3
fatty_acid: 16.2
CHC-CoA: 11.1
2-Methylbutyryl-CoA: 4.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (4023..4321): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.3
Ethylmalonyl-CoA: 202.7
Methoxymalonyl-CoA: 170.8
2-Methylbutyryl-CoA: 147.8
trans-1,2-CPDA: 116.6
Propionyl-CoA: 106.8
Malonyl-CoA: 101.0
CHC-CoA: 99.4
Isobutyryl-CoA: 84.6
Benzoyl-CoA: 69.2
Acetyl-CoA: 49.5
fatty_acid: 47.0
3-Methylbutyryl-CoA: 34.0
inactive: 26.7

Link to PARAS substrate predictor

NZ_JAASAG010000026.1 - Region 1 - T1PKS

Download region GenBank file

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Location: 1 - 7,375 nt. (total: 7,375 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acylase

HCC61_RS29960: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002171.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002596.2	0.54	PKS	lecanoric acid, orsellinic acid	Claviceps purpurea 20.1
BGC0002749.2	0.51	NRPS, PKS	aspcandine	Aspergillus candidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000107.3	0.60	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002171.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002596.2	0.54	PKS	lecanoric acid, orsellinic acid	Claviceps purpurea 20.1
BGC0002749.2	0.51	NRPS, PKS	aspcandine	Aspergillus candidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7375:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS29960: mal

PKS_AT (1021..1306): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.4
inactive: 101.7
Methoxymalonyl-CoA: 60.1
Methylmalonyl-CoA: 54.1
Propionyl-CoA: 30.1
Acetyl-CoA: 27.0
Benzoyl-CoA: 22.0
Ethylmalonyl-CoA: 21.6
Isobutyryl-CoA: 19.4
2-Methylbutyryl-CoA: 18.3
CHC-CoA: 12.8
fatty_acid: 12.2
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

NZ_JAASAG010000028.1 - Region 1 - T1PKS

Download region GenBank file

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Location: 1 - 3,090 nt. (total: 3,090 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HCC61_RS29980: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002171.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002749.2	0.50	NRPS, PKS	aspcandine	Aspergillus candidus
BGC0000122.5	0.49	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000043.5	0.49	PKS	curacin A	Moorea producens 19L
BGC0000353.5	0.47	NRPS	tacrolimus	Streptomyces sp. MA6548
BGC0000041.3	0.47	PKS	oronofacic acid	Pseudomonas syringae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002171.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.59	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002749.2	0.50	NRPS, PKS	aspcandine	Aspergillus candidus
BGC0000122.5	0.49	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000043.5	0.49	PKS	curacin A	Moorea producens 19L
BGC0000353.5	0.47	NRPS	tacrolimus	Streptomyces sp. MA6548
BGC0000041.3	0.47	PKS	oronofacic acid	Pseudomonas syringae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed domain annotation

Selected features only

Show module domains

NZ_JAASAG010000029.1 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 2,809 nt. (total: 2,809 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acylase

HCC61_RS29985: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.55	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.55	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002171.2	0.55	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.55	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002749.2	0.45	NRPS, PKS	aspcandine	Aspergillus candidus
BGC0000353.5	0.44	NRPS	tacrolimus	Streptomyces sp. MA6548
BGC0000122.5	0.43	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041.3	0.43	PKS	oronofacic acid	Pseudomonas syringae
BGC0000043.5	0.43	PKS	curacin A	Moorea producens 19L
BGC0002555.3	0.41	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.55	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.55	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002171.2	0.55	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.55	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0002749.2	0.45	NRPS, PKS	aspcandine	Aspergillus candidus
BGC0000353.5	0.44	NRPS	tacrolimus	Streptomyces sp. MA6548
BGC0000122.5	0.43	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041.3	0.43	PKS	oronofacic acid	Pseudomonas syringae
BGC0000043.5	0.43	PKS	curacin A	Moorea producens 19L
BGC0002555.3	0.41	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

HCC61_RS29985: pk

PKS_AT (292..594): pk

ATSignature: Ethylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 186.3
Ethylmalonyl-CoA: 183.2
Methoxymalonyl-CoA: 149.6
2-Methylbutyryl-CoA: 116.8
trans-1,2-CPDA: 108.9
Isobutyryl-CoA: 96.1
Malonyl-CoA: 92.6
CHC-CoA: 86.8
Propionyl-CoA: 81.0
Benzoyl-CoA: 53.7
3-Methylbutyryl-CoA: 39.7
Acetyl-CoA: 34.7
inactive: 29.5
fatty_acid: 28.6

Link to PARAS substrate predictor

NZ_JAASAG010000003.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 469,191 - 495,798 nt. (total: 26,608 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HCC61_RS10020: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: aminotransferase transferase

HCC61_RS10015: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

HCC61_RS10090: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Ligases: synthetase

HCC61_RS10070: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Translocases: transport

HCC61_RS10045: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.66	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000664.5	0.52	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000859.3	0.48	other (other)	ectoine	Methylomicrobium alcaliphilum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.66	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000664.5	0.52	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000859.3	0.48	other (other)	ectoine	Methylomicrobium alcaliphilum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

HCC61_RS10055: PT_phytoene_like

Domain 1 (7 - 283): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

HCC61_RS10060: PT_phytoene_like

Domain 1 (15 - 299): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → squalene; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

HCC61_RS10070: PT_FPPS_like

Domain 1 (59 - 355): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

HCC61_RS10075: T2TS

Domain 1 (25 - 676): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.94 out of 20.01

Confidence: medium

Additional weak hits (1):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.45 out of 25.75

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
ArgR	Regulator of arginine biosynthesis genes

NZ_JAASAG010000003.1 - Region 2 - T1PKS

Download region GenBank file

Download region SVG

Location: 787,239 - 821,818 nt. (total: 34,580 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase synthase

HCC61_RS11380: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

HCC61_RS11445: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase halogenase

HCC61_RS11450: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

HCC61_RS30655: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase synthase

HCC61_RS11380: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

HCC61_RS11455: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000996.5	0.47	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000170.3	0.45	PKS	yanuthone D	Aspergillus niger ATCC 1015
BGC0000927.3	0.44	other (flavin)	roseoflavin	Streptomyces davaonensis JCM 4913
BGC0000122.5	0.44	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0002697.3	0.44	NRPS, PKS	clipibicyclene, azabicyclene B, azabicyclene C, azabicyclene D	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000840.5	0.43	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000138.5	0.42	PKS	rimocidin	Streptomyces diastaticus
BGC0002152.2	0.42	other (other)	toxoflavin	Pseudomonas protegens Pf-5
BGC0000068.5	0.42	PKS	geldanamycin	Streptomyces hygroscopicus
BGC0001726.4	0.42	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000996.5	0.47	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000170.3	0.45	PKS	yanuthone D	Aspergillus niger ATCC 1015
BGC0000927.3	0.44	other (flavin)	roseoflavin	Streptomyces davaonensis JCM 4913
BGC0000122.5	0.44	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0002697.3	0.44	NRPS, PKS	clipibicyclene, azabicyclene B, azabicyclene C, azabicyclene D	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000840.5	0.43	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000138.5	0.42	PKS	rimocidin	Streptomyces diastaticus
BGC0002152.2	0.42	other (other)	toxoflavin	Pseudomonas protegens Pf-5
BGC0000068.5	0.42	PKS	geldanamycin	Streptomyces hygroscopicus
BGC0001726.4	0.42	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.37 out of 23.79

Confidence: medium

Additional weak hits (4):

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.88 out of 30.11

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.00 out of 27.04

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 787238 - 821818:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS30655: mal - mal - mmal

PKS_AT (537..823): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.4
inactive: 99.1
Methoxymalonyl-CoA: 77.4
Methylmalonyl-CoA: 67.4
Isobutyryl-CoA: 45.8
Propionyl-CoA: 35.9
Ethylmalonyl-CoA: 28.2
2-Methylbutyryl-CoA: 25.0
Benzoyl-CoA: 23.3
Acetyl-CoA: 21.1
fatty_acid: 11.9
CHC-CoA: 10.0
trans-1,2-CPDA: 5.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (1543..1830): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 89.6
Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 44.2
Ethylmalonyl-CoA: 25.5
CHC-CoA: 19.8
Isobutyryl-CoA: 19.5
Benzoyl-CoA: 19.5
Acetyl-CoA: 19.1
fatty_acid: 14.5
2-Methylbutyryl-CoA: 13.9
trans-1,2-CPDA: 13.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3212..3511): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.2
Ethylmalonyl-CoA: 209.5
Methoxymalonyl-CoA: 171.5
2-Methylbutyryl-CoA: 146.2
trans-1,2-CPDA: 121.1
Propionyl-CoA: 118.2
CHC-CoA: 83.7
Malonyl-CoA: 82.1
Isobutyryl-CoA: 78.7
Acetyl-CoA: 62.2
Benzoyl-CoA: 57.5
3-Methylbutyryl-CoA: 46.3
fatty_acid: 30.3
inactive: 29.6

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_JAASAG010000004.1 - Region 1 - NI-siderophore,NRP-metallophore,NRPS,t3nrps-iterative,terpene-precursor

Download region GenBank file

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Location: 71,195 - 208,400 nt. (total: 137,206 nt) Show pHMM detection rules used

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NI-siderophore: IucA_IucC
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase reductase

HCC61_RS11790: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

HCC61_RS11830: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

HCC61_RS11875: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HCC61_RS11935: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

HCC61_RS12070: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HCC61_RS12085: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

HCC61_RS12180: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: acetyltransferase formyltransferase methyltransferase

HCC61_RS11800: methyltransferase

smcogs: SMCOG1089: methyltransferase

HCC61_RS11940: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

HCC61_RS31485: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Hydrolases: hydrolase

HCC61_RS11860: isochorismatase

smcogs: SMCOG1027: isochorismatase

HCC61_RS12000: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

HCC61_RS12015: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: decarboxylase dehydratase hydratase

HCC61_RS11845: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

HCC61_RS11850: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

HCC61_RS11900: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

HCC61_RS12020: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase

HCC61_RS11870: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthetase

HCC61_RS11865: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HCC61_RS12115: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HCC61_RS12145: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

HCC61_RS30660: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002071.2	1.33	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0000946.5	1.32	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0002135.2	1.30	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	1.25	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	1.24	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	1.22	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	1.13	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	1.10	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	1.09	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	1.09	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002071.2	0.73	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.70	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

HCC61_RS12145: PT_FPPS_like

Domain 1 (67 - 366): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.92 out of 26.85

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.03 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.86 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 31.03 out of 36.53

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.15 out of 23.79

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.86 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.73 out of 36.53

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.48 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.36 out of 23.79

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (18):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.75 out of 30.25

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 36.53

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.74 out of 36.54

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.10 out of 36.53

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.39 out of 28.19

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 36.53

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.20 out of 39.62

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.40 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.71 out of 36.53

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.33 out of 20.01

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.38 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.79 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.74 out of 28.14

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.94 out of 33.73

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.86 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 71194 - 208400:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala - Gly - Thr - Ser - D-Leu) + (Thr - D-His - Val - D-X) + (D-X - Gly - D-Ser - D-OH-Orn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 71194 - 187936:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala - Gly - Thr - Ser - D-Leu) + (Thr - D-His - Val - D-X) + (D-X - Gly - D-Ser - D-OH-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS11865: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (38..444): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SVSLFPLSSPGGGLLVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPGLGVVNK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

HCC61_RS11965: Ala - Gly - Thr - Ser - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (467..882): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAATFDIAATELQALTAGEFNLYGPSETTVYSTG
Nearest Stachelhaus code(s):: Ala DIFQLALVYK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1530..1931): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAVLELQALAGGEVNLYGPTETTVWSTV
Nearest Stachelhaus code(s):: Gly DILQLGLVWK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2581..3037): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGELNMYGITETTVHVTE
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3709..4119): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWATFDVSVWEWFFFSSGEHNLYGPTEAAVHVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (88% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (4767..5177): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSQAFDASVMEMLIVVGGEVNAYGPTEVTACVTM
Nearest Stachelhaus code(s):: Leu DAMLVGAACK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

HCC61_RS11970: Thr - His - Val - X

Search NORINE for peptide: strict or relaxed

AMP-binding (476..943): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGSQVFGGEVNMYGITETTVHVTQ
Nearest Stachelhaus code(s):: Thr DFWSVGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1624..2025): His

nrpys: His

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTLAFDTSVWEMTVIVAGEFNSYGPTETTVDATL
Nearest Stachelhaus code(s):: His DTWTIASVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3128..3540): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDSSFDASTYEVWFWTGGDVNGYGPTETTTFATA
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4205..4610): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RWTAFDVSVWEGHFFSGGEVNQYGPTEAAVDVTA
Nearest Stachelhaus code(s):: His DYWHFGAVDK (82% 8Å match); Ser DVWHFSLVDK (79% 8Å match)
Stachelhaus code match:: 80% (moderate)

HCC61_RS30660: X - Gly - Ser - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (476..880): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWAAFDVTFCENVIIVGTEFNAYGPTEAVVNSAT
Nearest Stachelhaus code(s):: Fo-OH-Orn DVWIIGAVNK (62% 8Å match); Trp or Pro DVMFIGAVNK (50% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2002..2381): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LDITFDIAALEVQALSGGELNLYGPTETTVWSTA
Nearest Stachelhaus code(s):: Gly DILQLGLVWK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3092..3500): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFFASGEHNLYGPTEATVDVTA
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4660..5066): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSHWFDASWQPWEVGVGGEVNLYGPTEATVDSML
Nearest Stachelhaus code(s):: OH-Orn DAQEGGLVDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

HCC61_RS12115: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (2..398): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: VNLQHGAGYF-PKIVYGASIQDYGQSEAPMTITC
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JAASAG010000005.1 - Region 1 - NI-siderophore

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Location: 49,656 - 82,987 nt. (total: 33,332 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

HCC61_RS14020: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Isomerases: mutase

HCC61_RS14025: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001499.5	0.54	other (other)	aerobactin	Pantoea ananatis
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002682.2	0.50	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001499.5	0.54	other (other)	aerobactin	Pantoea ananatis
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002682.2	0.50	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.31 out of 27.18

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.14 out of 27.18

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72

Confidence: medium

Additional weak hits (11):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.88 out of 23.43

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.90 out of 33.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.29 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.54 out of 28.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.32 out of 27.18

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.47 out of 30.98

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.74 out of 27.04

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.04 out of 27.18

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
LexA variant 2	Repressor of DNA damage response
NrdR	Represses ribonucleotide reductase encoding genes
NtrC	Nitrogen regulatory protein C

NZ_JAASAG010000005.1 - Region 2 - hglE-KS

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Location: 196,834 - 249,138 nt. (total: 52,305 nt) Show pHMM detection rules used

hglE-KS: (hglE or hglD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

HCC61_RS14605: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: carbamoyltransferase glycosyltransferase

HCC61_RS14575: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

HCC61_RS14630: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

Hydrolases: hydrolase

HCC61_RS14490: isochorismatase

smcogs: SMCOG1027: isochorismatase

HCC61_RS14495: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

HCC61_RS14570: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: hydratase

HCC61_RS14645: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: synthase

HCC61_RS14555: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HCC61_RS14560: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001284.4	0.61	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.59	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000107.3	0.59	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.59	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001258.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001284.4	0.61	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.59	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000107.3	0.59	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.59	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001258.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26

Confidence: medium

Additional weak hits (14):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.37 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.43 out of 21.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.33 out of 28.14

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.65 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.33 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.90 out of 31.73

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.37 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.19 out of 21.55

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.18 out of 18.57

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.55 out of 29.38

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.02 out of 23.43

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.61 out of 29.65

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.61 out of 23.43

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 196833 - 249138:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (pk)
Non-colinear ordering:: HCC61_RS14555 + HCC61_RS14560 + HCC61_RS14565

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS14555: mal

PKS_AT (1259..1553): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 83.7
Methoxymalonyl-CoA: 36.6
inactive: 33.9
Methylmalonyl-CoA: 28.3
Propionyl-CoA: 20.1
Ethylmalonyl-CoA: 15.4
CHC-CoA: 14.8
trans-1,2-CPDA: 12.3
Isobutyryl-CoA: 9.4
Benzoyl-CoA: 9.4
fatty_acid: 9.3
2-Methylbutyryl-CoA: 7.4
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

HCC61_RS14560: pk

PKS_AT (674..891): pk

ATSignature: (unknown)

No matches above 50%

minowa: inactive

Prediction, score:

inactive: 13.8
Malonyl-CoA: 4.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAASAG010000005.1 - Region 3 - RiPP-like

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Location: 450,679 - 462,094 nt. (total: 11,416 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306.5	0.31	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0002553.2	0.30	other (other)	tunicamycin	Rathayibacter iranicus
BGC0002387.2	0.30	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0000529.5	0.29	ribosomal	microbisporicin A2	Microbispora corallina
BGC0000516.4	0.28	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001377.5	0.28	PKS	uncialamycin	Streptomyces uncialis
BGC0000874.5	0.28	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0002788.2	0.28	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001060.5	0.25	PKS	dynemicin A	Micromonospora chersina
BGC0000692.5	0.25	saccharide	apramycin	Streptoalloteichus hindustanus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000306.5	0.31	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0002553.2	0.30	other (other)	tunicamycin	Rathayibacter iranicus
BGC0002387.2	0.30	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0000529.5	0.29	ribosomal	microbisporicin A2	Microbispora corallina
BGC0000516.4	0.28	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001377.5	0.28	PKS	uncialamycin	Streptomyces uncialis
BGC0000874.5	0.28	other (other)	blasticidin S	Streptomyces griseochromogenes
BGC0002788.2	0.28	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001060.5	0.25	PKS	dynemicin A	Micromonospora chersina
BGC0000692.5	0.25	saccharide	apramycin	Streptoalloteichus hindustanus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

NZ_JAASAG010000006.1 - Region 1 - NRPS-like,RiPP-like,T2PKS,terpene

Download region GenBank file

Download region SVG

Location: 255,370 - 351,898 nt. (total: 96,529 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

HCC61_RS16720: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS16725: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS16750: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

HCC61_RS16785: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HCC61_RS16805: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

HCC61_RS16810: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

HCC61_RS16860: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

HCC61_RS16915: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HCC61_RS16925: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HCC61_RS16930: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HCC61_RS16955: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

HCC61_RS16960: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

HCC61_RS16975: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

HCC61_RS16985: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

HCC61_RS16995: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

HCC61_RS17030: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: PPTase aminotransferase glycosyltransferase methyltransferase transferase

HCC61_RS16885: methyltransferase

smcogs: SMCOG1248: methyltransferase

HCC61_RS16940: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

HCC61_RS16990: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

HCC61_RS17000: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

HCC61_RS17005: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

HCC61_RS17020: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

HCC61_RS17035: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

HCC61_RS17040: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: esterase

HCC61_RS16685: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

Lyases: cyclase dehydratase

HCC61_RS16895: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

HCC61_RS16920: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

HCC61_RS17010: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

HCC61_RS30760: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase synthetase

HCC61_RS16730: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

HCC61_RS16840: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HCC61_RS16900: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

HCC61_RS16905: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	1.19	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.97	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.85	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.79	PKS	oviedomycin	Streptomyces antibioticus
BGC0002047.2	0.64	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001197.5	0.58	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002383.3	0.58	PKS	kinanthraquinone B, kinanthraquinone	Streptomyces sp. SN-593
BGC0002672.2	0.55	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0000235.5	0.55	PKS	kiamycin	Streptomyces sp. W007

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.78	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002276.2	0.74	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000278.3	0.72	PKS	urdamycin	Streptomyces fradiae
BGC0002383.3	0.70	PKS	kinanthraquinone B, kinanthraquinone	Streptomyces sp. SN-593
BGC0002047.2	0.69	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0001723.5	0.67	PKS	oviedomycin	Streptomyces antibioticus
BGC0000235.5	0.60	PKS	kiamycin	Streptomyces sp. W007
BGC0001513.3	0.58	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000253.4	0.57	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Similar subclusters

Detailed terpene predictions

Product predictions:

Class	Chain length	Initial cyclisations	Functional groups
sesquiterpene	C15	C1-C6	none
diterpene	C20	C1-C6	none
diterpene	C20	C1-C7 + C6-C10	none
sesterterpene	C25	C1-C7 + C6-C10	none

Genes with terpene domains:

HCC61_RS16730: PT_FPPS_like

Domain 1 (77 - 258): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

HCC61_RS16735: TS_UbiA

Domain 1 (31 - 320): UbiA type terpene synthase

Reactions:: FPP → sesquiterpene_C1-C6; GGPP → diterpene_C1-C6; GGPP → diterpene_C1-C7/C6-C10; GFPP → sesterterpene_C1-C7/C6-C10

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.32 out of 23.43

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (24):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.37 out of 26.12

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.66 out of 20.97

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 17.78 out of 25.88

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.07 out of 33.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.15 out of 30.25

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.84 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.54 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.58 out of 30.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.68 out of 28.19

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.71 out of 28.14

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.27 out of 23.43

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 30.11

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.70 out of 27.78

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.11 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.42 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.70 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.37 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.45 out of 30.98

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 30.11

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.07 out of 30.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.73 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.89 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Type II PKS

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 255369 - 351898:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 278547 - 322345:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 279397 - 351898:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS16840: X

AMP-binding (104..571): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LASLHLAGRYMSMLMCGSALDGYGATEAGMITTG
Nearest Stachelhaus code(s):: nOct DAMMVGVMIK (29% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 279397 to 351898
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 713.3; E-value: 1.7e-217)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 593 Da
acetyl-CoA_9: 635 Da

HCC61_RS16785: KR (Score: 114.1; E-value: 2.1e-35)
HCC61_RS16895: CYC C4-C17/C2-C19 (Score: 196.1; E-value: 1.3e-60)
HCC61_RS16900: KS (Score: 797.5; E-value: 5.6e-243)
HCC61_RS16905: CLF 8|9 (Score: 713.3; E-value: 1.7e-217)
HCC61_RS16910: ACP (Score: 141.4; E-value: 1.6e-44)
HCC61_RS16915: KR C9 (Score: 488.1; E-value: 1.3e-149)
HCC61_RS16920: CYC C7-C12 (Score: 507.1; E-value: 3.3e-155)
HCC61_RS16925: OXY (Score: 599.9; E-value: 8.7e-183)
HCC61_RS16930: OXY (Score: 592.2; E-value: 1.8e-180)
HCC61_RS16940: GT (Score: 390.6; E-value: 2.4e-119)
HCC61_RS16985: OXY (Score: 504.2; E-value: 9.2e-154)
HCC61_RS16990: MET (Score: 256.1; E-value: 1.1e-78)
HCC61_RS17000: MET (Score: 262.4; E-value: 1.3e-80)

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
BldD	Development and antibiotic global regulator

NZ_JAASAG010000006.1 - Region 2 - NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 390,658 - 437,033 nt. (total: 46,376 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

HCC61_RS17245: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

HCC61_RS17260: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

HCC61_RS17300: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

HCC61_RS17310: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

HCC61_RS17335: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: methyltransferase transketolase

HCC61_RS17265: transketolase

smcogs: SMCOG1204: transketolase

HCC61_RS17320: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: phosphatase

HCC61_RS17315: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Lyases: lyase

HCC61_RS17330: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

HCC61_RS17270: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

HCC61_RS17290: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

HCC61_RS31245: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.63	NRPS	peramine	Epichloe festucae
BGC0001261.3	0.61	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.59	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.58	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.57	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001284.4	0.56	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001956.3	0.56	PKS	miharamycin A, miharamycin B	Streptomyces miharaensis
BGC0000307.4	0.55	NRPS	AbT1	Aureobasidium pullulans
BGC0002479.3	0.55	NRPS, PKS, saccharide	miharamycin B, miharamycin A	Streptomyces miharaensis
BGC0001240.4	0.55	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.65	NRPS	peramine	Epichloe festucae
BGC0001261.3	0.64	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.62	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001956.3	0.61	PKS	miharamycin A, miharamycin B	Streptomyces miharaensis
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0002479.3	0.61	NRPS, PKS, saccharide	miharamycin B, miharamycin A	Streptomyces miharaensis
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.42 out of 20.47

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.94 out of 27.04

Confidence: medium

Additional weak hits (15):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.15 out of 36.54

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.90 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.42 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.81 out of 27.78

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.63 out of 18.57

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.33 out of 25.75

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.96 out of 26.33

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.75 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.39 out of 36.54

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.90 out of 24.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.32 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.36 out of 35.63

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.45 out of 18.57

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.86 out of 33.14

Confidence: weak

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 390657 - 437033:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

HCC61_RS17290: X

AMP-binding (252..659): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RLEAF----REWSFFVGGEHNTYTLSEADYVCHR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

HCC61_RS31245: mal

PKS_AT (583..911): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 35.0
Methoxymalonyl-CoA: 31.2
Methylmalonyl-CoA: 19.9
inactive: 14.9
Isobutyryl-CoA: 9.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAASAG010000007.1 - Region 1 - ectoine

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Location: 367,885 - 378,289 nt. (total: 10,405 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

HCC61_RS19065: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase

HCC61_RS19080: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.85	other (other)	ectoine	Streptomyces anulatus
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.85	other (other)	ectoine	Streptomyces anulatus
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (5):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.36 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.64 out of 31.73

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.31 out of 21.55

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.32 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_JAASAG010000009.1 - Region 1 - RiPP-like

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Location: 277,620 - 288,426 nt. (total: 10,807 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002073.3	0.35	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002531.3	0.34	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0002115.3	0.34	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001498.5	0.33	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0002415.2	0.33	NRPS	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii
BGC0002682.2	0.32	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.32	other (other)	aerobactin	Grimontia hollisae
BGC0000947.5	0.31	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0001870.3	0.31	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002683.2	0.31	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002073.3	0.35	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002531.3	0.34	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0002115.3	0.34	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001498.5	0.33	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0002415.2	0.33	NRPS	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii
BGC0002682.2	0.32	other (other)	aerobactin	Vibrio mimicus
BGC0000939.5	0.32	other (other)	aerobactin	Grimontia hollisae
BGC0000947.5	0.31	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0001870.3	0.31	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002683.2	0.31	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.86 out of 36.53

Confidence: medium

Additional weak hits (6):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.15 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.60 out of 30.22

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.56 out of 36.53

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.95 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.86 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.73 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor