LOCUS       NZ_JAASAG010000026      7375 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. HNM0575 scfid26, whole genome shotgun sequence.
ACCESSION   NZ_JAASAG010000026
VERSION     NZ_JAASAG010000026.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. HNM0575
  ORGANISM  Streptomyces sp. HNM0575
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7375)
  AUTHORS   Xiao,K.
  TITLE     New actinomycetes from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7375)
  AUTHORS   Xiao,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-MAR-2020) College of Tropical Crops Hainan University,
            Hainan University, Renmin Avenue, HaiKou, HaiNan 570100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2018
            Assembly Method                   :: SOAPdenovo v. 1.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012726265.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 05:29:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,992
            CDSs (total)                      :: 5,923
            Genes (coding)                    :: 5,797
            CDSs (with protein)               :: 5,797
            Genes (RNA)                       :: 69
            rRNAs                             :: 5, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 126
            CDSs (without protein)            :: 126
            Pseudo Genes (ambiguous residues) :: 0 of 126
            Pseudo Genes (frameshifted)       :: 15 of 126
            Pseudo Genes (incomplete)         :: 115 of 126
            Pseudo Genes (internal stop)      :: 5 of 126
            Pseudo Genes (multiple problems)  :: 8 of 126
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7375
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAASAG010000026.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     protocluster    1..7375
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[<0:7348](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..7348)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     gene            complement(<1..7348)
                     /locus_tag="HCC61_RS29960"
                     /old_locus_tag="HCC61_29955"
     CDS             complement(<1..7348)
                     /NRPS_PKS="Domain: PKS_KR (73-253). E-value: 3.4e-60.
                     Score: 195.1. Matches aSDomain:
                     nrpspksdomains_HCC61_RS29960_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (349-435). E-value: 5.9e-33.
                     Score: 105.1. Matches aSDomain:
                     nrpspksdomains_HCC61_RS29960_PKS_PP.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (456-871). E-value:
                     1.5e-176. Score: 579.4. Matches aSDomain:
                     nrpspksdomains_HCC61_RS29960_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (1021-1306). E-value: 1.4e-107.
                     Score: 351.5. Matches aSDomain:
                     nrpspksdomains_HCC61_RS29960_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1714-1892). E-value: 8.4e-62.
                     Score: 200.3. Matches aSDomain:
                     nrpspksdomains_HCC61_RS29960_PKS_KR.2"
                     /NRPS_PKS="Domain: PKS_PP (2031-2115). E-value: 5.5e-28.
                     Score: 89.1. Matches aSDomain:
                     nrpspksdomains_HCC61_RS29960_PKS_PP.2"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (2140-2449). E-value:
                     3.1e-131. Score: 430.1. Matches aSDomain:
                     nrpspksdomains_HCC61_RS29960_PKS_KS.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF045894.1"
                     /locus_tag="HCC61_RS29960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_29955"
                     /product="type I polyketide synthase"
                     /protein_id="WP_346777444.1"
                     /sec_met_domain="mod_KS (E-value: 1.3e-219, bitscore:
                     715.4, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2.3e-109, bitscore:
                     351.5, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.3e-65, bitscore:
                     206.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.3e-15, bitscore:
                     43.2, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 9.6e-97, bitscore:
                     309.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGLLASGAGEDQVAVRDTGIYGRRLVPTELTVSAGSDGGGDAAS
                     ADSDAASDSESESVSSESSSAASGWVPSGSVLVTGGTGALGARVARWLVERGAGHVVLT
                     SRRGLDAPGADELRDELAGLGARVTIAACDAADRAALASVLEAIPEEFPLTAVVHAAGV
                     GVGDGPLESLESEQLAGVLRSKVNGAWHLHELTRDLDLDAFVLFGSGAGCWGSGGQPAY
                     GAANAFLDGLAQYRRGQGLPATSFAWGAWGDAGMATDEAMAGHLERRGLVPMEPELALW
                     VLGRAVAEDRTLLTVTNTDWELFAPSFTAERPSALLSEIPQVQRVLAEPDTDPDGQDGS
                     SGESGLKGRLAGLPEAERSRELLELVRTHAAAALGYSDAEALPANRAFRDVGFDSVIAV
                     ELRNRLKRATGIPLPATLVFDHPTPNALAGFLHGELFGTETAPEPAVQVLPPVTDDPIA
                     VVGMGCRYPGGVSTPEELWQLVAEGRDAISAFPADRGWDLNALTSATYEGGFLADVAGF
                     DAEFFGISPREAVVMDPQQRLLLETSWEALERGSIDPAALRGSRTGVFMGTTGQDYADL
                     VAHSTEDVGLYATTAHAASVLSGRISYLLGLEGPAATIDTACSSSLVAMHWAAQALRSG
                     ECDLALAGGVAVMSTPNAFAAFTSQGGLAPDGRCKAFSDAADGTGWSEGAGVVLLERLS
                     DARRNGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALASAGLSSSDVDAVEAH
                     GTGTTLGDPIEAQAVLATYGQSRERPLLLGSIKSNIGHPQSAGGVAGVIKMVMALREGL
                     LPKTLHVDEPSTHVDWSAGAVELLTDAADWPEADRLRRAGVSSFGVSGTNAHLILEQAP
                     LPAPVQEAETAADPHVSESDTDDAPGNAPVAETETETATDAMPVATPPTQIATHGTAGS
                     APVPVPALVPWVVSARSEAALQAQLDRVSALADRAGDGSTPPAATPVDIGYSLAACRTA
                     FEHRAVLLHSEEGTAEAERAVAPAEDRLLAFAFSGQGSQRLGMGRELYESFPVFADAFD
                     AVLAHLDPQLRSTVWGEDTDALNDTGWAQPALFAVEVALYRLAESWGVTPDYLIGHSVG
                     EIAAAHVSGVLSLEDACTLVSARARLMRDLPAGGAMAAVEATEDELLALLDGRDDVALA
                     AVNGPTSVVVSGADTAVREIAESFAGKGRKTRNLLVSHAFHSPLMDAMLDDFHAAVAGL
                     SFGEPAIPVVSNLTGRIATGEELRSATYWVRHVRETVRFADGVAALAEQGVTAFLEVGP
                     DGVLSAMAAESVPGSVAVPLLRKDRPEDHTAVTAVARLHVNGARVEWARYFDGTGARPA
                     ELPTYPFQHQRYWPEPATGAGSGTGAAASGTDRTDDAAFWTLVESGDLDTLAAELGVAP
                     DTELTSLGEVLPALTSWRNRRRAQSTIDSWRYRETWTPLAATGGEPRGPRTEPQGKGSW
                     LAVLPAAAATGSEDEAWIAQALEALGSDVVQVRIPGDGDAAGTPQRDELAAHLAAALAR
                     TASEDTESGDDTESGDAPAPSAQPQLTGVVSLLALDGAEDASGVPAAVRNTLLLVQALA
                     DSAVTAPVWAVTRNAVAVDATEGVDGTAQAGVWGLGRVAAMELPQQWGGLVDLPATLDR
                     RTTRRFTDVLGAAVAGHPDGTNSGGATSTGSTGSTGGTGQGHSAEEDQLAVRASGLFGR
                     RLVPAPHADPGTAWQPSGTVLVTGGTGALGAHVARDLAARGAQRLVLLSRRGPEAPGAD
                     RLRGELTALGAEVDIVACDAADREGLSAVLAGLPADQPLTGVVHTAGVLDDGILEGLTP
                     ERFEDVFRSKVAAARALDELTRGLDLSAFVLFSSVAGQIGNPGQANYAAANAVLDSLAR
                     TRRAEGLPATAVAWGAWAGEGMAAGETGPGGAAEDTGDAETTETEDTGDAQDIGGGNGA
                     DGGADSATGSGRSTWPERDGAGLMDPRLAVEAMWQAAGEEPATVTIADLRNPQLLGSLL
                     EVRPMPLLSELPDAQRAVEELRATRDTSRAAASELRERLEGLGEADRYEAALDLVRSRI
                     ATVLNYSGGTAVGADKAFRDLGFDSLTAVELRNQLSAAIGQTLPAGLVFDHPTPRALAG
                     HLLEEILGIQGESATAATRGTAAPRTTDEPVAIVGMSCRFPGDIRTPEDFWQFLLDGRD
                     GIGDFPTDRNWDLETLFSGGQGSSITRNGGFLDGTADFDAAFFGISPREALAMDPQQRL
                     LLESSWEALERAGVDPQSLRGSSTGVFVGTNGQDYATLVNDSAQDTEGHAATGLAASVI
                     SGRLSYTLGLEGPAMTVDTACSASLVALHLAGQALRQGECDMALAGGATVMSTPMVFAE
                     LSRQGALSPDGRCKAFADGADGTGWSEGVGLLVLERLSDAERLGHRVLAVVRGSAVNQD
                     GASNGLTAPNGPSQQRVIRQALSAAGLAASDVDAVEAHGTGTAL"
     source          1..7375
                     /collection_date="2018-06-19"
                     /country="China: HaiKou"
                     /db_xref="taxon:2716338"
                     /host="sponge"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. HNM0575"
                     /strain="HNM0575"
                     /submitter_seqid="scfid26"
     region          1..7375
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..7375
                     /SMILES="CC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     aSDomain        complement(2..928)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: False"
                     /ASF="found active site histidines: False"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS29960_PKS_KS.2"
                     /domain_subtypes="Modular-KS"
                     /evalue="3.10E-131"
                     /label="HCC61_RS29960_PKS_KS.2"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="2449"
                     /protein_start="2140"
                     /score="430.1"
                     /tool="antismash"
                     /translation="VAIVGMSCRFPGDIRTPEDFWQFLLDGRDGIGDFPTDRNWDLETL
                     FSGGQGSSITRNGGFLDGTADFDAAFFGISPREALAMDPQQRLLLESSWEALERAGVDP
                     QSLRGSSTGVFVGTNGQDYATLVNDSAQDTEGHAATGLAASVISGRLSYTLGLEGPAMT
                     VDTACSASLVALHLAGQALRQGECDMALAGGATVMSTPMVFAELSRQGALSPDGRCKAF
                     ADGADGTGWSEGVGLLVLERLSDAERLGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQR
                     VIRQALSAAGLAASDVDAVEAHGTGTAL"
     CDS_motif       complement(5..31)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0017"
                     /evalue="2.70E+00"
                     /label="PKSI-KS_m5"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="2448"
                     /protein_start="2439"
                     /score="2.4"
                     /tool="antismash"
                     /translation="VEAHGTGTA"
     CDS_motif       complement(227..265)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0016"
                     /evalue="2.50E+00"
                     /label="PKSI-KS_m4"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="2374"
                     /protein_start="2361"
                     /score="2.3"
                     /tool="antismash"
                     /translation="FADGADGTGWSEG"
     CDS_motif       complement(407..454)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0015"
                     /evalue="3.60E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="2314"
                     /protein_start="2298"
                     /score="19.0"
                     /tool="antismash"
                     /translation="GPAMTVDTACSASLVA"
     CDS_motif       complement(656..682)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0014"
                     /evalue="4.20E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="2231"
                     /protein_start="2222"
                     /score="7.1"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     aSDomain        complement(1004..1255)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS29960_PKS_PP.2"
                     /evalue="5.50E-28"
                     /label="HCC61_RS29960_PKS_PP.2"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="2115"
                     /protein_start="2031"
                     /score="89.1"
                     /tool="antismash"
                     /translation="EGLGEADRYEAALDLVRSRIATVLNYSGGTAVGADKAFRDLGFDS
                     LTAVELRNQLSAAIGQTLPAGLVFDHPTPRALAGHLLEE"
     aSModule        complement(1004..5980)
                     /complete
                     /domains="nrpspksdomains_HCC61_RS29960_PKS_KS.1"
                     /domains="nrpspksdomains_HCC61_RS29960_PKS_AT.1"
                     /domains="nrpspksdomains_HCC61_RS29960_PKS_KR.2"
                     /domains="nrpspksdomains_HCC61_RS29960_PKS_PP.2"
                     /locus_tags="HCC61_RS29960"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(1673..2206)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N found: True"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS29960_PKS_KR.2"
                     /evalue="8.40E-62"
                     /label="HCC61_RS29960_PKS_KR.2"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1892"
                     /protein_start="1714"
                     /score="200.3"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVLVTGGTGALGAHVARDLAARGAQRLVLLSRRGPEAPGADRLR
                     GELTALGAEVDIVACDAADREGLSAVLAGLPADQPLTGVVHTAGVLDDGILEGLTPERF
                     EDVFRSKVAAARALDELTRGLDLSAFVLFSSVAGQIGNPGQANYAAANAVLDSLARTRR
                     AEGLPATAVAWGAWA"
     CDS_motif       complement(1718..1822)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0013"
                     /evalue="1.90E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1877"
                     /protein_start="1842"
                     /score="62.2"
                     /tool="antismash"
                     /translation="AFVLFSSVAGQIGNPGQANYAAANAVLDSLARTRR"
     CDS_motif       complement(2105..2203)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0012"
                     /evalue="5.10E-13"
                     /label="PKSI-KR_m1"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1748"
                     /protein_start="1715"
                     /score="41.6"
                     /tool="antismash"
                     /translation="TVLVTGGTGALGAHVARDLAARGAQRLVLLSRR"
     aSDomain        complement(3431..4285)
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS29960_PKS_AT.1"
                     /evalue="1.40E-107"
                     /label="HCC61_RS29960_PKS_AT.1"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1306"
                     /protein_start="1021"
                     /score="351.5"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="FSGQGSQRLGMGRELYESFPVFADAFDAVLAHLDPQLRSTVWGED
                     TDALNDTGWAQPALFAVEVALYRLAESWGVTPDYLIGHSVGEIAAAHVSGVLSLEDACT
                     LVSARARLMRDLPAGGAMAAVEATEDELLALLDGRDDVALAAVNGPTSVVVSGADTAVR
                     EIAESFAGKGRKTRNLLVSHAFHSPLMDAMLDDFHAAVAGLSFGEPAIPVVSNLTGRIA
                     TGEELRSATYWVRHVRETVRFADGVAALAEQGVTAFLEVGPDGVLSAMAAESVPGSVAV
                     PLLR"
     CDS_motif       complement(3557..3592)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0011"
                     /evalue="7.40E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1264"
                     /protein_start="1252"
                     /score="16.1"
                     /tool="antismash"
                     /translation="YWVRHVRETVRF"
     CDS_motif       complement(3815..3853)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0010"
                     /evalue="1.20E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1178"
                     /protein_start="1165"
                     /score="12.2"
                     /tool="antismash"
                     /translation="AAVNGPTSVVVSG"
     CDS_motif       complement(3947..4066)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0009"
                     /evalue="7.50E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1134"
                     /protein_start="1094"
                     /score="72.8"
                     /tool="antismash"
                     /translation="GVTPDYLIGHSVGEIAAAHVSGVLSLEDACTLVSARARLM"
     CDS_motif       complement(4079..4123)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0008"
                     /evalue="1.90E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1090"
                     /protein_start="1075"
                     /score="11.6"
                     /tool="antismash"
                     /translation="AQPALFAVEVALYRL"
     CDS_motif       complement(4238..4285)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0007"
                     /evalue="2.40E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="1037"
                     /protein_start="1021"
                     /score="16.9"
                     /tool="antismash"
                     /translation="FSGQGSQRLGMGRELY"
     aSDomain        complement(4736..5980)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS29960_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="1.50E-176"
                     /label="HCC61_RS29960_PKS_KS.1"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="871"
                     /protein_start="456"
                     /score="579.4"
                     /tool="antismash"
                     /translation="IAVVGMGCRYPGGVSTPEELWQLVAEGRDAISAFPADRGWDLNAL
                     TSATYEGGFLADVAGFDAEFFGISPREAVVMDPQQRLLLETSWEALERGSIDPAALRGS
                     RTGVFMGTTGQDYADLVAHSTEDVGLYATTAHAASVLSGRISYLLGLEGPAATIDTACS
                     SSLVAMHWAAQALRSGECDLALAGGVAVMSTPNAFAAFTSQGGLAPDGRCKAFSDAADG
                     TGWSEGAGVVLLERLSDARRNGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQAL
                     ASAGLSSSDVDAVEAHGTGTTLGDPIEAQAVLATYGQSRERPLLLGSIKSNIGHPQSAG
                     GVAGVIKMVMALREGLLPKTLHVDEPSTHVDWSAGAVELLTDAADWPEADRLRRAGVSS
                     FGVSGTNAHLILEQAP"
     CDS_motif       complement(5057..5101)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0006"
                     /evalue="7.30E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="764"
                     /protein_start="749"
                     /score="11.9"
                     /tool="antismash"
                     /translation="VEAHGTGTTLGDPIE"
     CDS_motif       complement(5297..5335)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0005"
                     /evalue="4.00E-01"
                     /label="PKSI-KS_m4"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="684"
                     /protein_start="671"
                     /score="4.7"
                     /tool="antismash"
                     /translation="FSDAADGTGWSEG"
     CDS_motif       complement(5477..5524)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0004"
                     /evalue="5.10E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="624"
                     /protein_start="608"
                     /score="18.5"
                     /tool="antismash"
                     /translation="GPAATIDTACSSSLVA"
     CDS_motif       complement(5726..5752)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0003"
                     /evalue="4.20E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="541"
                     /protein_start="532"
                     /score="7.1"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     aSDomain        complement(6044..6301)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS29960_PKS_PP.1"
                     /evalue="5.90E-33"
                     /label="HCC61_RS29960_PKS_PP.1"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="435"
                     /protein_start="349"
                     /score="105.1"
                     /tool="antismash"
                     /translation="LAGLPEAERSRELLELVRTHAAAALGYSDAEALPANRAFRDVGFD
                     SVIAVELRNRLKRATGIPLPATLVFDHPTPNALAGFLHGEL"
     aSModule        complement(6044..7129)
                     /domains="nrpspksdomains_HCC61_RS29960_PKS_KR.1"
                     /domains="nrpspksdomains_HCC61_RS29960_PKS_PP.1"
                     /incomplete
                     /locus_tags="HCC61_RS29960"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(6590..7129)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS29960_PKS_KR.1"
                     /evalue="3.40E-60"
                     /label="HCC61_RS29960_PKS_KR.1"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="253"
                     /protein_start="73"
                     /score="195.1"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: A1"
                     /tool="antismash"
                     /translation="GSVLVTGGTGALGARVARWLVERGAGHVVLTSRRGLDAPGADELR
                     DELAGLGARVTIAACDAADRAALASVLEAIPEEFPLTAVVHAAGVGVGDGPLESLESEQ
                     LAGVLRSKVNGAWHLHELTRDLDLDAFVLFGSGAGCWGSGGQPAYGAANAFLDGLAQYR
                     RGQGLPATSFAWGAWGD"
     CDS_motif       complement(6638..6748)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0002"
                     /evalue="2.40E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="237"
                     /protein_start="200"
                     /score="52.2"
                     /tool="antismash"
                     /translation="LDAFVLFGSGAGCWGSGGQPAYGAANAFLDGLAQYRR"
     CDS_motif       complement(7028..7126)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS29960_0001"
                     /evalue="1.80E-14"
                     /label="PKSI-KR_m1"
                     /locus_tag="HCC61_RS29960"
                     /protein_end="107"
                     /protein_start="74"
                     /score="46.2"
                     /tool="antismash"
                     /translation="SVLVTGGTGALGARVARWLVERGAGHVVLTSRR"
ORIGIN
        1 ccaacgccgt ccccgtacca tgcgcctcca ccgcatccac atccgacgcc gcaagacccg
       61 cagccgacaa cgcctgccga atcacccgct gctgcgacgg accattcggc gccgtcaaac
      121 cattcgacgc accgtcctga ttcaccgcgc tgccccgcac caccgccagc acccgatgcc
      181 caagacgctc cgcatccgag agccgctcca acaccaacaa ccccacgccc tcggaccagc
      241 ccgtaccgtc cgcaccgtcc gcgaacgcct tgcaccggcc gtcgggggac agggctccct
      301 ggcgggagag ttcggcgaag accatgggcg tggacatcac ggttgcgccg ccggcgagcg
      361 ccatgtcgca ctccccctga cgcagggcct gtccggccag gtggagggcg acgagcgagg
      421 cggagcaggc cgtgtccacc gtcatggcgg ggccttcgag gccgagcgtg taggagaggc
      481 gaccggagat gacgctcgcc gcgaggccgg ttgcggcgtg gccttcggtg tcctgggcgc
      541 tgtcgttgac gagagtggcg tagtcctgtc cgttggtgcc gacgaagaca ccggtcgaac
      601 tgccgcgcag cgactgcgga tcgaccccgg cacgctccag cgcctcccac gacgactcca
      661 gcagcagcct ctgctggggg tccatcgcca gcgcctcacg cggcgagatg ccgaagaacg
      721 cggcgtcgaa gtcggcggtt ccgtcgagga agccgccgtt ccgagtgatg ctgctgccct
      781 ggccgccgga gaagagggtc tccaggtccc agttgcggtc ggtggggaag tcgccgatgc
      841 cgtcccggcc gtcgaggagg aactgccaga agtcctcggg cgtgcggatg tctccgggga
      901 agcggcagga catgccgacg atggccaccg gctcgtcggt cgtgcgcggg gcggcggtgc
      961 cgcgggtcgc agccgtcgcc gactcgccct ggatgccgag gatctcctcc aggaggtggc
     1021 ccgcgagggc gcgtggtgtg gggtggtcga agacgaggcc ggcgggcagg gtctgcccga
     1081 tggcggcgct gagctggttg cgcagttcga cggcggtgag cgagtcgaat ccgaggtcgc
     1141 ggaaggcctt gtcggcgccg accgccgtgc cgccggagta gttgaggacg gtggcgatgc
     1201 gggagcgtac gaggtcgagt gcggcttcgt agcggtctgc ctcgccgagt ccctcaagcc
     1261 gttcgcggag ttcggaggcc gctgcacgac tcgtgtcgcg cgtggcccgg agctcctcca
     1321 ccgcccgctg tgcgtcgggg agttcggaca ggagcggcat ggggcgtact tcgagcaggg
     1381 agccgagaag ctgcgggttg cgcagatcgg cgatcgtgac ggtggcgggc tcctcgccgg
     1441 cggcctgcca catggcctcc acggccagtc gcgggtccat cagtccggcg ccgtcgcgtt
     1501 ccggccatgt gctgcggccg gagccggtgg cgctgtcggc accgccgtcg gcgccgttgc
     1561 cgccgccgat gtcctgcgcg tcgccggtgt cctcggtctc ggtggtctcg gcgtcgccgg
     1621 tgtcctcagc ggcgcctccg gggcccgtct cgcccgcggc catgccctcc cccgcccagg
     1681 cgccccaggc gacggcggtg gcgggcagtc cttcggcgcg gcgggtccgg gcgagggagt
     1741 ccagcacggc gttcgccgcg gcgtagttgg cctgcccggg gttgcctatc tgaccggcga
     1801 cggaggagaa gaggacgaac gccgacaggt cgaggccgcg ggtgagttcg tcgagtgcgc
     1861 gggcggcggc gacctttgag cggaagacgt cttcgaagcg ttcgggggtg agcccttcga
     1921 ggatgccgtc gtccaggacg ccggcggtgt ggacgacgcc ggtcagcggc tggtcggcgg
     1981 ggagcccggc gaggacggcg gagaggcctt cccggtcggc cgcgtcgcag gcgacgatgt
     2041 ccacttcggc gccgagcgcg gtgagttcgc cgcgcagccg gtccgcgccc ggagcttcgg
     2101 ggccgcggcg gctgaggagg acgaggcgct gtgcgccgcg ggcggcgagg tcgcgggcga
     2161 cgtgcgcgcc gagggcgccg gtgccgccgg tgacgagcac cgtgcccgag ggctgccagg
     2221 cggtgccggg atcggcgtgc ggcgcgggca cgagcctgcg gccgaacaag ccggaggcgc
     2281 ggacggcgag ttggtcctcc tccgcgctgt ggccctgacc cgtgccgccg gtgctgccgg
     2341 tgctgccggt gctggtggcg ccaccactgt tcgtcccgtc ggggtgtccg gcgacggccg
     2401 cgcccagtac gtcggtgaag cggcgcgtcg tgcgccggtc gagcgtcgcc ggaaggtcta
     2461 cgagtccgcc ccactgctgc ggcagttcca tcgcggcgac gcggccgagg ccccacacgc
     2521 ccgcctgcgc ggtgccgtcg acgccttcgg tggcgtccac ggcgacggca ttgcgggtga
     2581 cggcccatac gggagcggtg accgcgctgt cggcgagtgc ctgcacgagc agcagggtgt
     2641 tccgtacggc ggcgggcacg cccgaggcgt cctccgcgcc gtcgagggcc aacagggaga
     2701 cgacgcctgt gagttggggc tgcgccgacg gtgcgggtgc gtcaccgctc tccgtgtcgt
     2761 caccgctctc cgtgtcctcg ctggcggtcc gggcgagggc cgccgccaag tgcgcggcca
     2821 gttcgtcccg ttgcggcgtg cctgcggcgt ctccgtcgcc ggggatgcgg acttggacga
     2881 cgtcggagcc gagggcttcg agggcttgcg cgatccacgc ctcgtcctcg gagccggtcg
     2941 cggccgcggc gggcaggacg gcgagccagc tccccttccc ctgcggctcg gtgcgcgggc
     3001 cgcggggctc gccgccggtg gcggccagtg gcgtccatgt ctcccggtag cgccaggagt
     3061 cgatggtgga ctgggcgcgg cggcggttgc gccacgaggt gagggcgggc aacacctcgc
     3121 ccagagaggt gagttcggtg tcgggggcga cgcccagttc ggcagcgagg gtgtccaggt
     3181 cgccgctttc gacgagggtc cagaacgcgg cgtcgtcggt tcggtcggtc ccgctcgctg
     3241 cggcacccgt accggaaccg gcaccggtgg cgggttccgg ccagtaccgc tggtgctgga
     3301 acgggtaggt gggcagttcg gcggggcggg cgccggtgcc gtcgaagtag cgtgcccact
     3361 ccacgcgggc gccgttgacg tggaggcgtg ccaccgcggt gacggccgtg tggtcctccg
     3421 gccggtcctt gcggagcagc ggcacagcga ccgacccggg cacggactcc gcggccatcg
     3481 cggagagcac tccgtcgggg ccgacctcca ggaacgccgt gacgccctgt tcggcgagcg
     3541 cggcgacgcc gtcggcgaac cgtacggtct cccgcacgtg ccgcacccag tacgtcgcag
     3601 agcgcagctc ctcgccggtg gcgatgcggc cggtgaggtt ggatacgacg gggatcgcgg
     3661 gctcgccgaa ggacaggccg gccacggccg cgtggaagtc gtccagcatc gcgtccatca
     3721 agggcgagtg aaatgcatga ctgaccagca aattcctagt cttgcggccc ttgccggcga
     3781 agctctccgc gatctcccgt acagccgtgt ccgctccgga aaccaccacg gacgtggggc
     3841 cgttgacggc ggcgagcgcc acgtcgtccc tgccgtcgag cagcgcgagc agttcgtcct
     3901 cggtggcctc cacggcggcc atggccccgc cggcggggag gtcccgcatc agccgggccc
     3961 gggcggagac gagggtgcag gcgtcctcga gtgagaggac gccggagacg tgtgcggcgg
     4021 cgatctcccc gaccgagtgg ccgatcaggt agtcgggcgt gacgccccag gattcggcca
     4081 gacggtagag ggccacctcg acggcgaaca gggcgggttg ggcccagccg gtgtcgttca
     4141 gcgcgtccgt gtcctcgccc catacggtgc tgcgcagttg ggggtccagg tgggccagta
     4201 cggcgtcgaa ggcgtcggcg aagacgggga agctttcgta caactcccgt cccatgccga
     4261 ggcgttggct gccctgaccg gagaaggcga acgccagcag ccggtcctcg gcgggcgcga
     4321 cggcgcgctc ggcctccgcg gtcccctcct cgctgtgcag cagtacggca cggtgctcga
     4381 acgccgtgcg gcaggcggcg agggagtagc cgatgtcgac gggggtggcg gcgggcggtg
     4441 tgctgccgtc gccggcgcgg tccgcgaggg cgctgacccg atcgagctgg gcctggagcg
     4501 cggcctccga ccgggcggag accacccacg gcacgagcgc gggaacgggc acgggtgcgc
     4561 tcccggccgt gccatgggtg gcgatctggg tcgggggcgt ggctacgggc atggcgtcgg
     4621 tggcggtttc ggtttcggtt tccgcgacgg gcgcgttgcc gggggcgtcg tcggtgtcgc
     4681 tctcggatac gtgggggtcg gcggccgtct cggcttcctg cacgggcgcg ggcagtggcg
     4741 cctgttccag gatgaggtgc gcgttggtgc cgctgacgcc gaaggaggac acacctgccc
     4801 tgcggagccg gtccgcctcg ggccagtcgg cggcgtcggt gaggagttcg acggcgccgg
     4861 cgctccagtc gacgtgggtg gacggctcgt ccacgtgcag cgtcttgggg aggaggcctt
     4921 ccctcagggc catgaccatc ttgatgacgc ccgcgacgcc gcccgcggac tgcgggtggc
     4981 cgatgttgga cttgatggag cccagcagca gcggccgctc gcggctctgg ccgtaagtgg
     5041 ccagcactgc ctgggcctcg atggggtcgc cgagtgtcgt gccggtgccg tgcgcctcca
     5101 cggcgtccac gtcggaggac gagagacctg cgctcgccaa cgcctgccgg atgacgcgct
     5161 gttgggacgg gccgttgggc gcggtcagcc cgttggaggc gccgtcctga ttcactgcgc
     5221 tgccccgtac gaccgccagc acgcggtggc cgttgcggcg tgcgtcggag agccgctcca
     5281 gcaggacgac gccggcgccc tcggaccagc cggtgccgtc ggcggcgtcg gagaacgcct
     5341 tgcagcggcc gtcgggcgcg agaccgccct gggaggtgaa ggcggcgaag gcgttcggcg
     5401 tggacatcac ggccactccg cccgccagcg ccaggtcgca ctccccggag cgcagcgcct
     5461 gcgccgccca gtgcatcgcc accagcgacg aggagcacgc ggtgtcgatg gtggcggccg
     5521 ggccctccag gccgagcagg taggagatgc ggccggagag gacgctcgcg gcgtgggcgg
     5581 tggtggcgta gaggccgacg tcctccgtgg agtgggcgac gaggtcggcg tagtcctgac
     5641 cggtggtgcc catgaagacg ccggtgcggc tgccgcgcag tgcggcgggg tcgatgctgc
     5701 cgcgttcgag ggcctcccag ctcgtctcca gcagcagccg ctgctgcggg tccatcacga
     5761 cggcttcgcg gggcgagatc ccgaagaact cggcgtcgaa tccggcgacg tcggcgagga
     5821 agccgccctc gtacgtggcg ctggtcaggg cgttgaggtc ccatccgcgg tccgcgggga
     5881 aggcggagat cgcgtcacgt ccctcggcga cgagctgcca cagctcctca ggggtgctga
     5941 cgccgccggg gtaacggcag cccatgccga cgacggcgat ggggtcgtcg gtcacgggcg
     6001 gcagcacctg gaccgccggt tcgggtgcgg tctcggtgcc gaagagttcg ccgtgcagga
     6061 atcccgccag ggcgttgggt gtggggtggt cgaagacgag ggtggcgggc aggggaatgc
     6121 cggtggcgcg cttgagccgg ttgcgcaact cgacggcgat gacggagtcg aaacccacat
     6181 cacggaaagc acgattggct ggcagcgcct cggcatcgct gtaacccagg gccgctgcgg
     6241 cgtgggtacg gaccagttcc agcagctccc gggaacgctc cgcctccggc agccccgcca
     6301 ggcgcccctt cagccccgac tcgccgctgc tgccgtcctg cccgtcgggg tcggtgtccg
     6361 gttcggcgag tacgcgctgg acctggggga tctccgagag caacgcgctg ggacgctccg
     6421 ccgtgaaact cggcgcgaac agctcccagt ccgtattcgt caccgtcagc agcgtccggt
     6481 cctcagcgac ggcccggccc agcacccaca acgccaactc cggctccatg ggcaccagac
     6541 cacggcgctc cagatgcccc gccatcgcct cgtccgtggc catgcccgcg tcgccccagg
     6601 caccccatgc gaaggaggtg gcaggcaggc cctgaccacg ccggtactgc gccaacccat
     6661 ccaggaacgc gttcgccgcc ccgtacgccg gctgaccacc gctgccccag cagccggcgc
     6721 ccgagccgaa cagtacgaaa gcgtccagat ccagatcacg ggtcagctcg tgcagatgcc
     6781 aggctccgtt caccttcgac cgcagtacgc cggccagctg ctcggactcc agcgattcca
     6841 acggcccgtc accgacgccg acacctgcgg cgtggacgac ggccgtcagc ggaaactcct
     6901 ccggaatcgc ctccagcacg ctcgccaagg cggcgcggtc cgccgcatca caggcggcga
     6961 tcgtcacccg ggcacccagg cccgccagct catcgcgcaa ctcatcggcg cctggggcgt
     7021 ccaggccccg gcggctggtc aacaccacat ggcctgcgcc ccgttcaacc agccaccgtg
     7081 ccacccgcgc acccaacgca cccgtaccac ccgtcaccaa caccgacccc gacggcaccc
     7141 aacccgaggc agcagacgac gactcggacg agacggactc ggactcagag tcggaggcgg
     7201 catcggagtc ggcggacgcg gcatcgccgc cgccatcact cccggcggaa accgtcagtt
     7261 cggtgggtac gaggcggcgg ccgtagatac ccgtgtcgcg gacagcgacc tgatcctcac
     7321 ccgcgccaga cgccaacagc ccagccacac cacgcccgat ctcctcgttc cacga
//
