LOCUS       NZ_JAASAG010000011     22058 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. HNM0575 scfid11, whole genome shotgun sequence.
ACCESSION   NZ_JAASAG010000011
VERSION     NZ_JAASAG010000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. HNM0575
  ORGANISM  Streptomyces sp. HNM0575
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 309321)
  AUTHORS   Xiao,K.
  TITLE     New actinomycetes from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 309321)
  AUTHORS   Xiao,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-MAR-2020) College of Tropical Crops Hainan University,
            Hainan University, Renmin Avenue, HaiKou, HaiNan 570100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2018
            Assembly Method                   :: SOAPdenovo v. 1.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012726265.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 05:29:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,992
            CDSs (total)                      :: 5,923
            Genes (coding)                    :: 5,797
            CDSs (with protein)               :: 5,797
            Genes (RNA)                       :: 69
            rRNAs                             :: 5, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 126
            CDSs (without protein)            :: 126
            Pseudo Genes (ambiguous residues) :: 0 of 126
            Pseudo Genes (frameshifted)       :: 15 of 126
            Pseudo Genes (incomplete)         :: 115 of 126
            Pseudo Genes (internal stop)      :: 5 of 126
            Pseudo Genes (multiple problems)  :: 8 of 126
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 92626
            Orig. end                         :: 114684
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAASAG010000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22058
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22058
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22058
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12058](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12058)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            431..679
                     /locus_tag="HCC61_RS24360"
                     /old_locus_tag="HCC61_24355"
     CDS             431..679
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072371.1"
                     /locus_tag="HCC61_RS24360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24355"
                     /product="SCO4226 family nickel-binding protein"
                     /protein_id="WP_169138860.1"
                     /transl_table=11
                     /translation="MPRFIDVHHGMKGITAEQLDNAHRADLAAEHTEGVHFEHAWADPE
                     TGTVFCLSEAPSADAVRRAHRRAGNSVEEVYTVPLSV"
     gene            789..1091
                     /locus_tag="HCC61_RS24365"
                     /old_locus_tag="HCC61_24360"
     CDS             789..1091
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840241.1"
                     /locus_tag="HCC61_RS24365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24360"
                     /product="hypothetical protein"
                     /protein_id="WP_169138862.1"
                     /transl_table=11
                     /translation="MTFVQIIEYETNRADELNAVFAQWMKVTEGKRTVLREMHGQDRDD
                     PGHFVDIVEFPSYQKAMENSQLPETQQVADQARALCTSGPRFVNLEVQREQIKES"
     gene            complement(1152..2057)
                     /locus_tag="HCC61_RS24370"
                     /old_locus_tag="HCC61_24365"
     CDS             complement(1152..2057)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175562.1"
                     /locus_tag="HCC61_RS24370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24365"
                     /product="phosphatidylinositol-specific phospholipase C
                     domain-containing protein"
                     /protein_id="WP_169138864.1"
                     /transl_table=11
                     /translation="MDLKRRHFLRGTAAIPLAVLLGGTAAGVAEAVSSDAETAGPEAWM
                     SQLPDGVRLPELTVPGTHNSGATHGGPWTECQNTSLTEQLSAGIRFLDIRCRLFDGSFT
                     IHHGSTYQYLNFEDVLGSCREFLTAQPSETILMRLKQEYSEESAEQFRVVFEDYLDGDG
                     GWRSLFRLDPVLPDLGDARGRVVLLGDSDGLPGVRYGDPELFDVQDAYMEEPGAKYPLI
                     EDQFRKAVDQPGKLYVNFVSTAALLPLRSNADRLNPRVRDLVQADENSSWRGLGIVPMD
                     FPNEHGVIEALLKHQPAAAT"
     gene            complement(2175..2372)
                     /locus_tag="HCC61_RS24375"
                     /old_locus_tag="HCC61_24370"
     CDS             complement(2175..2372)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HCC61_RS24375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HCC61_24370"
                     /product="hypothetical protein"
                     /protein_id="WP_240969256.1"
                     /transl_table=11
                     /translation="MTGERLPMDLKAYEARARSGVCFACAFVSGDPEFHHETVHEDDEH
                     IAFLDRARLRRACAVRFGGR"
     gene            complement(2369..3052)
                     /locus_tag="HCC61_RS24380"
                     /old_locus_tag="HCC61_24375"
     CDS             complement(2369..3052)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105915.1"
                     /locus_tag="HCC61_RS24380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24375"
                     /product="hypothetical protein"
                     /protein_id="WP_169138866.1"
                     /transl_table=11
                     /translation="MHTSGHPLLRLFLDAADGRFPPSDGGVTVLDPLPRGLECSVAFTG
                     HAVIATALPAEEVYALRPDGFGGSLAPDVLRALAGPEGTVGCVDAVLTARGTGGRPRLP
                     EVDGVEDSPRVRHARELRTGIRTFGDERGLVVLADGLAGRREISCELHDPPHAAGRGLG
                     RSLIRDALTLAPPGEPLFAAVSPGNARSLRAFLAAGFTPIASESILRPARRQPAAKISE
                     LEGPP"
     gene            complement(4888..5364)
                     /locus_tag="HCC61_RS24385"
                     /old_locus_tag="HCC61_24380"
     CDS             complement(4888..5364)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019549434.1"
                     /locus_tag="HCC61_RS24385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24380"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_169138868.1"
                     /transl_table=11
                     /translation="MRIVRVPYDHPEARKLNDAVQEEYAERYGDEGDITPLDPAMFEPP
                     HGLYLIAYDDEGRPVASGGWRTQHANDEGYADGDAEIKRMYVVREARGRGLARRILKAL
                     EDDARAVGRTRMVLETGIVQPEAIGLYVSSGYEPTEKFGLYRFEPRSRCYAKPL"
     gene            5388..6191
                     /locus_tag="HCC61_RS24390"
                     /old_locus_tag="HCC61_24385"
     CDS             5388..6191
                     /EC_number="3.1.11.2"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359589.1"
                     /locus_tag="HCC61_RS24390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24385"
                     /product="exodeoxyribonuclease III"
                     /protein_id="WP_169138870.1"
                     /transl_table=11
                     /translation="MPKVTTINVNGLRAAARKGYREWLAATDADVVCLQEVRAEPHQLP
                     DDVRAPDGWHTVFAPAAAKGRAGVALLTRREPDQVRIGFGAEEFEDSGRYAEVDLPGMT
                     VASLYLPSGDVGTERQAQKERFMAAFLPYLRGLRERAAADGREVLVCGDWNIAHQEADL
                     KNWRGNRRNSGFLPEEREWLSRVFDASDGGYHDVVRRLHPDVEGPYSWWSYRGRAFDND
                     SGWRIDLAAATPGLAERAVKAYVERAASHDERWSDHAPVSVDFVP"
     misc_feature    5397..5410
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            6228..7433
                     /locus_tag="HCC61_RS24395"
                     /old_locus_tag="HCC61_24390"
     CDS             6228..7433
                     /EC_number="2.8.2.-"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050656 - 3'-phosphoadenosine
                     5'-phosphosulfate binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175782.1"
                     /locus_tag="HCC61_RS24395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24390"
                     /product="sulfotransferase"
                     /protein_id="WP_206322980.1"
                     /transl_table=11
                     /translation="MGGAGTERADVAQGAEGADVAEGTDVAEGTDAADSTDAAEGTDVA
                     TARTLTFVVGTGRCGSTALSRVLRLHPDVLSVSELIASVEPGALPEQPLTGKEFWQLLS
                     TGRPFADRMVREGTPLPEHLYPGVPGGRFSAAGGGIPALCLTTLPHLTDDPDALYDALE
                     PVLAARDRTPVAEHYRALFDELARWAGGRSAVVERSGFSLGYVPRLRAAFPEARFVHLH
                     RYGPDCALSMSRHAGFRLLRTAAQAEAGSPEQELAVRLGELTADDSFDLRGVLERPVPV
                     ERFGELWSGMVADGMERLAKVPRALLASLSYEDLLDAPERELTALARHIGVEPRTDWLR
                     AAAGLLDGARRGAAEALPADELARLRESCTPGMRALGREGHGDRREGHGDRRDRHDGPD
                     GQ"
     gene            complement(7427..8326)
                     /locus_tag="HCC61_RS24400"
                     /old_locus_tag="HCC61_24395"
     CDS             complement(7427..8326)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (20-260). E-value: 1e-58. Score:
                     191.2. Matches aSDomain:
                     nrpspksdomains_HCC61_RS24400_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058155.1"
                     /locus_tag="HCC61_RS24400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24395"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_346777367.1"
                     /sec_met_domain="TauD (E-value: 4.3e-58, bitscore: 191.2,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAPTGPQATDDPKLPHGMSVRPVSGAIGAELHGIDLTELDDELF
                     DSIHELLLRHLVLFIPGQSGLTPEAHVALGRRFGEVEVHPFLPKLDSHPEVTLIESDKG
                     GKADEWHIDVTFSPNPPVASILHLVTCPESGGDTMWSNQYLAYETLSEPFKEMLNGLTA
                     VHVLQAPEVGTFSAEHPVVRVHPETGRRSLYVTRMWTSHIPQLTRNESDAVLQYLFEHS
                     ESPRFNCRYRWEPGAVAIWDNRATQHLAINDYQEYRKGQRVTVLGDHPTGDAPRWKEYE
                     RRGDERYYPRRVNARSGY"
     aSDomain        complement(7547..8266)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS24400_TauD.1"
                     /evalue="1.00E-58"
                     /label="HCC61_RS24400_TauD.1"
                     /locus_tag="HCC61_RS24400"
                     /protein_end="260"
                     /protein_start="20"
                     /score="191.2"
                     /tool="antismash"
                     /translation="VRPVSGAIGAELHGIDLTELDDELFDSIHELLLRHLVLFIPGQSG
                     LTPEAHVALGRRFGEVEVHPFLPKLDSHPEVTLIESDKGGKADEWHIDVTFSPNPPVAS
                     ILHLVTCPESGGDTMWSNQYLAYETLSEPFKEMLNGLTAVHVLQAPEVGTFSAEHPVVR
                     VHPETGRRSLYVTRMWTSHIPQLTRNESDAVLQYLFEHSESPRFNCRYRWEPGAVAIWD
                     NRATQHLAINDYQEYRKG"
     misc_feature    complement(8454..8465)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(8469..10004)
                     /locus_tag="HCC61_RS24405"
                     /old_locus_tag="HCC61_24400"
     CDS             complement(8469..10004)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058156.1"
                     /locus_tag="HCC61_RS24405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24400"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_240969257.1"
                     /transl_table=11
                     /translation="MSDGYGEYDVVVCGAGAGGLASARALDAIGLRVLVVDKQRSPRHV
                     AKGEVLQPGALRALRRWGTDRLLTRDGALRLGRLVVRDPAGAPVMTLDYGRLPPADSSL
                     LAHDHLAVLEALTAGLGPGVEIRRGVRVVEALRDDSGRVVGVRLDGGRHRDEDVNGNGD
                     GNGDGDADGDRDRGEDGNSDADGDADGTSSGDGTQDVYAPLVVAADGIGSRLRRAVGIG
                     GSRSDYPHRLVSFELDGPPLRPEDFSAYLTDRGLRLVYPLPGGRVRLYVQARPDELRGL
                     DRAGFARWGADAVREVPALAPLAEAVPAAAGTRQLFPVARFLAERLTAPGLALVGESAY
                     AVHPMAAQGMNSAITCAASLAERLAEQLTPAVGPLESEPSEVSEASDPSEASGSPERSE
                     AREPRTRGPLTREPLTRDVVDAALRGYELERLPVLAHAARTSDNAARMVTDLSWPGRVL
                     GRRAVRCTGANPRLLHTITYNMAGLGPRPLTLLDRLHQIGLLPDPRAHRVPQE"
     gene            complement(10001..12058)
                     /locus_tag="HCC61_RS24410"
                     /old_locus_tag="HCC61_24405"
     CDS             complement(10001..12058)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058157.1"
                     /locus_tag="HCC61_RS24410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24405"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_240969258.1"
                     /sec_met_domain="T2TS (E-value: 1.3e-39, bitscore: 130.0,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSRELAGAVRTSVDAGCEALFALQRPDGVFAPGGDRFSPANTAA
                     ALISLHHAEGTDRTGGTGGTDRTGETDDAQGPDGTGAPDDASPTARGDADELGAAAVTR
                     LLNSQRPDGGWAMAGVPTELLATAAATAALRLTAPERAEGAIRAGADFVDRLGGPGALP
                     EPTMAGLVRQFDALSGAGDLASLPRLPLEILLLRGPARRLLSLRLPIFASMALAQSAHR
                     APPPLLAPFNARARAEALRVVRDAYEREGSTGEFSTDPWLTGLISLGVTRSGLAPDITR
                     ASARRLRAMARPEDGGWDLMPLDVTWSSFAAAALLEAGRAADPRLAATRAMFHERQQKE
                     PFAALGCPPGYWGFSSAYSWPMALETAEVSSALLSMPGGAGDEHARRGVEWLTAMQDPS
                     GSWSLAVRGSKPGGFGPCPHMTAKAVRTLLDHGARPQDRRVVRALRWLSRVQHEDGSFE
                     AMWYRGRTAGTAVVLETFCRAGLGDGETARRARERLLRTQSEDGSWGTPDAEDPAGARG
                     NGGHGDDGGTVEDTAWALHALLTAGADPHGEPVAGAARRLTEWQRDDGSWPGAPVNEYV
                     RHCSRYADDGIASGLALRALARLRSALDAEGHDDGPGDGDRVDGDQVDTEADTEADTEA
                     DTEATTKTATATKTGNQGDGDGARARTRSGTGTGGRNAAASGRTKGAGAS"
     gene            complement(12052..13392)
                     /locus_tag="HCC61_RS24415"
                     /old_locus_tag="HCC61_24410"
     CDS             complement(12052..13392)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058158.1"
                     /locus_tag="HCC61_RS24415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24410"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_169138872.1"
                     /sec_met_domain="ubiA (E-value: 1.1e-20, bitscore: 68.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAHEVEHIPATAAREGRAPGDLPVERALRACARTGKAHIETWRP
                     YTLAYPGLVGLAGAALNSTEGTAADGYPDAGRLLVAWAAPTLGWVSGHYIGDWFDRALD
                     AISKPQRPLPSGRLGPRAALTCGIGCAAAAAVAAATVNWRTVVLFAVAMLGIVAYSRLL
                     KGRGLTGNAVRGALTATTVIFGAMTVAELPSWQVLLFAGVFCAQDTASNLVGTLRDVEG
                     DRRGGCRTVPVRHGVRAAVRTATALHTAALVTAVPALLLVKGGPGSGALALLLCAAACG
                     VAAFVPLLRHGMGERTSEGRDVGERTGADVRRDGGETVGEGAAGGEPGAPAAAPAVLDP
                     RRALRAHEVLVAERMLLAGALLAVGWGPVPALAVVVPLLAVSLVAQSRMRSRHEFPDPD
                     PDADAAKAADPGARAGGAPGTSPDGAPQAPHAAATEHQSLRGDVTSC"
     gene            complement(13421..14611)
                     /locus_tag="HCC61_RS24420"
                     /old_locus_tag="HCC61_24415"
     CDS             complement(13421..14611)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (113-351). E-value:
                     3.3e-39. Score: 127.0. Matches aSDomain:
                     nrpspksdomains_HCC61_RS24420_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058160.1"
                     /locus_tag="HCC61_RS24420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24415"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_240969259.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.4e-38, bitscore:
                     127.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPVIGSAPVLHQMSLNETFFPPSPGVLRAVHEAAADSHRTNDAL
                     ATGLTGRIAERLGVPAADVLVGPGSAALLQQLFSALTGPGAAGAAGPAGSADSTGSAGS
                     AGSPGSAAGAGSATVHAWPSWEAYPMLAANAGSATVRVPLRDDDSHDLDAMADAVTDQT
                     RMVVLCHPNNPTGTALRHSDAERFLARLPSHVTVVVDEAYRDFVRDDFAADGITLYRDD
                     ERVCVVRTFSKSYGLLGLRVGYVVGHPRTLGPLRGLQPFIRVSNTAQAAAQAALAEEKE
                     FRRRCEVTVGERERLYGRLLELGWEVRPSQANFLWLPMTEGVEHFTQFCADHGVLVCGK
                     PGEGVRVTVAEREANDAFAELAGKFGGERPHDEGGSGGDRTSGGTHGTDGDGGDVP"
     aSDomain        complement(13559..14272)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS24420_Aminotran_1_2.1"
                     /evalue="3.30E-39"
                     /label="HCC61_RS24420_Aminotran_1_2.1"
                     /locus_tag="HCC61_RS24420"
                     /protein_end="351"
                     /protein_start="113"
                     /score="127.0"
                     /tool="antismash"
                     /translation="AGSATVHAWPSWEAYPMLAANAGSATVRVPLRDDDSHDLDAMADA
                     VTDQTRMVVLCHPNNPTGTALRHSDAERFLARLPSHVTVVVDEAYRDFVRDDFAADGIT
                     LYRDDERVCVVRTFSKSYGLLGLRVGYVVGHPRTLGPLRGLQPFIRVSNTAQAAAQAAL
                     AEEKEFRRRCEVTVGERERLYGRLLELGWEVRPSQANFLWLPMTEGVEHFTQFCADHGV
                     LVCGKPGEGVRVTVAE"
     gene            complement(15132..15932)
                     /locus_tag="HCC61_RS24425"
                     /old_locus_tag="HCC61_24420"
     CDS             complement(15132..15932)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605091.1"
                     /locus_tag="HCC61_RS24425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24420"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_346777379.1"
                     /transl_table=11
                     /translation="MREFRAAELAELAGITTRTLRFYRERKLLPPPRREGRIAWYDEHH
                     LARLHTIAGLLNRGHTLGGIVDLLGAFESGRDSQRTAELLGLESSMITSLFAEETPIRL
                     TPEELADYYQGEVTVENLAAALDIGYIAVDGDEFVHVSRRLLDASSELVKKGIPLAAVL
                     ASGRELRKQSEGIADVFVHLFRTHLLPKEQADAAPEGLDAECLDDLLRQLRPLAKQVFE
                     AELGLALDRRVRAEVEQWIAQREPGPPTTADPPGTGTGTAAADG"
     misc_feature    complement(16567..16582)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            16625..18313
                     /locus_tag="HCC61_RS24430"
                     /old_locus_tag="HCC61_24425"
     CDS             16625..18313
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659818.1"
                     /locus_tag="HCC61_RS24430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24425"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_169138878.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6e-15, bitscore:
                     49.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAEREHEHVRVAVIGSGFGGLGAAVRLRRAGVTDFVVLERREAV
                     GGTWHDNTYPGCACDVPSHLYSFSFAPNPDWPRAFSGQKHIRAYLEDVADNFGLRQHIR
                     FSSEVELMSWDPEELHWSITTARGDRLSADFVVNATGPLSDAKIPDIPGLEGFGGKVFH
                     TARWDHDYDLRGKRVAVIGTGASAIQVVPAIQPEVERLTLFQRTPAWVMPRADREISTL
                     ERRLHAKVPATGYLRRQILWGIRELQVSAFAKHPKMLGLIEGLATSHMKRAVKDPVMRR
                     KLTPQYRIGCKRILLSNDYYPALARPNTELVASGLKEVRGNTLVASDGSEAEVDAIVFG
                     TGFHVTDMPIAQRVKGADGTTLAESWSEGMEALRGCSASGFPNFMTVIGPNTGLGNSSM
                     ILIIEAQLNYMVDYVKKLETLGGDAGKVAFDARPEAVTAWNGHIQDRMRRSVWNTGCDS
                     WYLDANGRNTTVWPGTTAEFRKVTREVRLEEYEVLRRPAARGTAGSGAEGSGAEASDTG
                     ASGTPGSRAAGSRTASPGATRATRAARGKSGRSTATSAFHSAEEA"
     gene            18313..19419
                     /locus_tag="HCC61_RS24435"
                     /old_locus_tag="HCC61_24430"
     CDS             18313..19419
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (44-285). E-value: 1e-21.
                     Score: 69.6. Matches aSDomain:
                     nrpspksdomains_HCC61_RS24435_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091116.1"
                     /locus_tag="HCC61_RS24435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24430"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_169138880.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-17, bitscore: 58.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-22, bitscore:
                     75.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARLTASWGRTPGPYDPPPPARELTATSADGARLHVEVHGDAKDP
                     AVVLIHGWTCSTAFWAAVIRELTASGHRVIAYDQRGHGRSPGTGARTYGPDSLADDLCA
                     VLEAALEPGERAVLCGHSMGAMTLIAAAGRPALEARAAAVLLCNTGARRLMASARVIPL
                     RSEPARVRAHRLLLLSRLPLGPVSPLTRKALKYGTMGPDSPPEQVDAMARIVHACRPRE
                     RGAWGAVLSKLDISGRVRALTPPTEVIAGTSDRLTPPALAREIADALPRCTGLHELPRR
                     GHMAPVETSSEVSEVLRRLVREHLMETAATPSRKSPGTRQAQQSGKPRPTQKSQRTQKS
                     QRTQKSQRTQQTQRTQQTQSMTEREETP"
     aSDomain        18445..19167
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS24435_Abhydrolase_1.1"
                     /evalue="1.00E-21"
                     /label="HCC61_RS24435_Abhydrolase_1.1"
                     /locus_tag="HCC61_RS24435"
                     /protein_end="285"
                     /protein_start="44"
                     /score="69.6"
                     /tool="antismash"
                     /translation="PAVVLIHGWTCSTAFWAAVIRELTASGHRVIAYDQRGHGRSPGTG
                     ARTYGPDSLADDLCAVLEAALEPGERAVLCGHSMGAMTLIAAAGRPALEARAAAVLLCN
                     TGARRLMASARVIPLRSEPARVRAHRLLLLSRLPLGPVSPLTRKALKYGTMGPDSPPEQ
                     VDAMARIVHACRPRERGAWGAVLSKLDISGRVRALTPPTEVIAGTSDRLTPPALAREIA
                     DALPRCTGLHELPRRGHMA"
     gene            19416..20306
                     /locus_tag="HCC61_RS24440"
                     /old_locus_tag="HCC61_24435"
     CDS             19416..20306
                     /NRPS_PKS="Domain: PKS_KR (10-175). E-value: 5e-16. Score:
                     51.1. Matches aSDomain:
                     nrpspksdomains_HCC61_RS24440_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524866.1"
                     /locus_tag="HCC61_RS24440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24435"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_169138882.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-33, bitscore:
                     109.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRRRSLEGQVAVVTGAARGVGELLARKLSARGAKIALIGLEPDE
                     LKKVSESLRTESAYWHGDVTDDDAMRRIADEVGERFGKVDVAVANAGVASGGPFTDSDA
                     ESWRRVIEVNLLGGAATARAFLPRLIASRGYFLQIASLAAITPAPMMSAYCASKSGVEA
                     FAHCLSAEVGHKGVRVGVGYLSWTDTDMVRGADEDDVMRDLRKRLPWPANRTYPLGPSV
                     DRLVAGIERRSRHVYGQWWLRGMQGIRGYLPPVIGTVGQREMRRFEPRLAESGTRTGLV
                     GAGGAADEGERAARL"
     aSDomain        19446..19940
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS24440_PKS_KR.1"
                     /evalue="5.00E-16"
                     /label="HCC61_RS24440_PKS_KR.1"
                     /locus_tag="HCC61_RS24440"
                     /protein_end="175"
                     /protein_start="10"
                     /score="51.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAARGVGELLARKLSARGAKIALIGLEPDELKKVSESLRT
                     ESAYWHGDVTDDDAMRRIADEVGERFGKVDVAVANAGVASGGPFTDSDAESWRRVIEVN
                     LLGGAATARAFLPRLIASRGYFLQIASLAAITPAPMMSAYCASKSGVEAFAHCLSAEVG
                     HK"
     CDS_motif       19452..19532
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HCC61_RS24440_0001"
                     /evalue="7.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="HCC61_RS24440"
                     /protein_end="39"
                     /protein_start="12"
                     /score="15.4"
                     /tool="antismash"
                     /translation="VVTGAARGVGELLARKLSARGAKIALI"
     gene            complement(20519..21310)
                     /locus_tag="HCC61_RS24445"
                     /old_locus_tag="HCC61_24440"
     CDS             complement(20519..21310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007263401.1"
                     /locus_tag="HCC61_RS24445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_24440"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_169138884.1"
                     /transl_table=11
                     /translation="MTTASDAASVTPNDTLRAVRIGLRLSQDDLARALQRAGHAAGDPN
                     GASKRLVQRWESGRIRRPRPLYTRALESVTGLPVESLGFQVPVPMARVTSDGRGGHDMD
                     HSTDGVTAAVGAPRSAPSTAAENYSGIWLSRYEFFSSGREATFKGAHFVVLLQHGSQLK
                     GHSLEGASLNPDSPLSLDLRIDRNVVTGTWAEQTATDGYYRGARYHGAIQLLVEPTGRR
                     MVGKWVGFGKDMDVNTGPWELVFQDASTAKETLEAYSRAPE"
     misc_feature    complement(21236..21238)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21425..21435)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            21430..21597
                     /locus_tag="HCC61_RS24450"
                     /old_locus_tag="HCC61_24445"
     CDS             21430..21597
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HCC61_RS24450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HCC61_24445"
                     /product="hypothetical protein"
                     /protein_id="WP_169138886.1"
                     /transl_table=11
                     /translation="MADEEKAGGCGVCAALLKQVDKAVGEYDRSAEVDARVKLRRHMRQ
                     IHGRELPLAW"
ORIGIN
        1 cagcgcggac gccaggttct caaccgtcgg gggcttggag gacttcgaca cgttcgcggt
       61 gcccgagtcg ccgccgcatc cgccgagcag cagcgccgcg gaggcgaccg cgaccaccgg
      121 gaggacgaac ctgccggcac cgcgcgacgg ggacctcggc ggtgcccctt cgcagcgccg
      181 ctgggcgctg tcggcctcgg ccggtggcaa ctggtctctc atcagcgctc cctgggacgg
      241 atagggctcc acgactctag gtcgagtccg cggcgggcgg ccgtctttgt catcggcgtg
      301 aagggttccg gacgggcctc accggcaggt gtcgcatggg agttgaatga gggggtttgg
      361 gggttttcgc ccatcggtag caccatggga gtcgacgggg tcctcaccgc gaccacggag
      421 gtggagagct gtgcccagat tcatcgacgt acaccacggg atgaagggca tcacggcgga
      481 gcagctcgac aacgcccacc gggcggatct cgccgccgag cacacggagg gcgtgcactt
      541 cgagcacgcg tgggccgacc ccgagacggg gacggtcttc tgtctgtcgg aggcgccttc
      601 cgcggatgcc gtacggcgcg cacaccggcg tgcggggaac tcggtggagg aggtctacac
      661 ggtgccgctc agcgtgtgaa cgccgccgct cagtgtgcgg ccgccgtgcc accggaagcg
      721 ttccgcgaag gatgtgcggc acgcatgtcg cgggtgccac ggcagagact gcgacaggag
      781 gccaggccat gacattcgtc cagatcatcg agtacgagac gaatcgcgcg gacgaactga
      841 acgccgtatt cgcccagtgg atgaaggtga cggagggcaa gcggaccgtg ctgcgcgaga
      901 tgcacggaca ggaccgcgac gaccccggtc acttcgtgga catcgtcgaa ttcccctcgt
      961 accagaaggc gatggagaac agccagctgc cggagacgca gcaggtcgcc gaccaggcgc
     1021 gtgcgctgtg cacgtcgggg ccgcgcttcg tgaacctgga ggtgcagcgc gagcagatca
     1081 aggagagctg agacgcggcg agcagccagc cgccgcgtca ccgttgccgt ccatgtccgc
     1141 gctgtggccg cttacgtggc ggctgccggc tggtgcttca acagtgcctc gatgacgccg
     1201 tgttcgttcg ggaagtccat ggggacgatg cccaggccgc gccaggacga gttctcgtcc
     1261 gcctggacca ggtcccgtac gcgggggttg agccggtcgg cgttggagcg gagcggcagc
     1321 agcgcggccg tgctgacgaa gttcacgtac agcttccccg gttggtcgac ggccttgcgg
     1381 aactgatcct cgatcagcgg gtacttggcg cccggctcct ccatgtacgc gtcctggacg
     1441 tcgaagagct ccgggtcgcc gtagcgcacc ccggggagtc cgtccgagtc gcccagcagc
     1501 acgaccctgc cgcgggcgtc tcccagatcc gggaggacgg ggtcgagccg gaagagggag
     1561 cgccagccgc cgtcgccgtc cagatagtcc tcgaacacga cccggaactg ctcggcgctc
     1621 tcctcggagt actcctgctt gaggcgcatc aggatcgtct cggaaggctg cgcggtgagg
     1681 aactcgcggc aactgcccag tacgtcctcg aagttgagat actgataggt ggagccgtgg
     1741 tggatggtga aggagccgtc gaagagccgg caccggatgt cgaggaagcg gatgcccgcc
     1801 gaaagctgtt ccgtgaggct ggtgttctgg cattcggtcc acggaccgcc gtgcgtggca
     1861 ccggagttgt gggtgccggg gacggtcagc tccggcaggc gcacgccgtc cggaagctgg
     1921 gacatccagg cctccgggcc ggcggtctcg gcgtcggagg acaccgcctc cgcgacgccg
     1981 gctgcggtgc cgccgagcag tacggcgagg gggattgcgg ccgtgccgcg gaggaagtgg
     2041 cgccgcttca ggtccatgcc aatgatggaa tcacagcgga acgctttccc acagggtgca
     2101 aatgagccca cgggacgcgg acgagccttc ccggcgccac cgcctccgga gccccgcctt
     2161 ccccatggcg cgccttaccg cccgccgaac ctcacggcac aggcccggcg cagccgcgcg
     2221 cggtcgagga aggcgatgtg ctcgtcgtcc tcgtggacgg tctcgtgatg gaactccggg
     2281 tcgccggaga cgaacgcgca ggcgaagcac acccccgaac gcgccctcgc ctcatacgcc
     2341 ttcagatcca tcggcagccg ctcaccggtc acgggggtcc ttccagttcg gagatcttcg
     2401 cggccggctg acggcgggcc gggcggagga tggattcgct cgcgatcggg gtgaagcccg
     2461 ccgcgaggaa ggcgcggagg gagcgggcgt tgccggggga gaccgcggcg aagaggggtt
     2521 cgccgggcgg ggcgagggtg agggcgtcac ggatgaggga gcggcccagg ccgcggccgg
     2581 cggcgtgggg cggatcgtgg agttcgcagc tgatctcgcg gcgtccggcc agcccgtcgg
     2641 cgaggacgac caggccgcgt tcgtcgccga acgtccttat gcccgtgcgc agttcgcggg
     2701 cgtgccggac gcgggggctg tcctccacgc cgtcgacctc cggcagcctc ggccgtccgc
     2761 ccgtaccgcg ggcggtgagg acggcgtcga cgcagccgac ggtgccttcg gggccggcga
     2821 gcgcccgcag cacatcgggc gcgagggagc cgccgaagcc gtcgggccgc agcgcgtaca
     2881 cctcttccgc gggcagcgcg gtggcgatca cggcgtggcc cgtgaaggcg accgagcact
     2941 ccaggccgcg ggggagcggg tccagcacgg tcacgccgcc gtcggacggc gggaagcgtc
     3001 cgtcggcggc gtcgaggaac aggcgcagca gggggtgccc ggatgtgtgc atggggtcag
     3061 cctcacacgg gcgcgcggcg gtccggcggg aagtgcggtg acggcgggga ggaggcgggg
     3121 cgacggcggg gagggggcgg attggcgccg cgggggcggg cgcgcgaggc tgggccccat
     3181 gagcatcgcg ttcctcttcc ccggccgggg gtcgcagcgt cccggcatgc tgcacaggct
     3241 gcccgacacg gcggcgtccg cgaccgtact ggccgaggcg gactgggcgt tgcggcggct
     3301 cgcggcccgt acgggcggcc cgggcacgga ggacgccggg cacggcggag gcagggagta
     3361 cgcggacggc atcgtcgggc tcgactccga ggaagcgctc gaacgctcgc ccgtcgcatg
     3421 ccacttggcg ctgctgatcg cgggcgtcgc gggtgcgcgc gcgctgatcg aggacgagga
     3481 ggtgcggccc tcgtacgtcg ccggtcacgg cacgggcggc tatgcggcgg cggtgctcgc
     3541 ggacgtgctc accttcgagg aggcgctgcg ggccgtacgg ctcagagggg agctgctgca
     3601 cgacgccgag cgcgcgaacg cgcccgagag cgatgtcgcg atccggctcg cgcagcatct
     3661 ggcgacggtc aagaggcgtc cgcagtcggt gcgttacgtc gggggagtgc aggggcggtc
     3721 gctgttcggc gagacgaacg ccgtcttcga cgacctcgcg tggtctgccg cacgtcccgt
     3781 gcgctggccg caggtgacgg cggtgctggc gggggagaag gtggcgtgct gcgtcgaact
     3841 gccgccgggg cgtgcgctga cggggcagct ggcggctgcc cggctgcccg gcatgcaggc
     3901 ggtgtccgtg gaggagcacg gcatcgcgga ggcggcggac ctggcacggt cggcggcggg
     3961 tatggatatg cgccggggcg gcgcgggcgg cgacggggcg gaggacgcgg cggcggacgg
     4021 cgcggcggcg gacggtgaca taccgggggg cgcgtttccg ggcggtgcgg gtgcgcctcc
     4081 ggatgccccg ggcggcccgg cccccggccc cggccccgtt tcgggttccg gtcccgggtc
     4141 aggccccggc cccgttccgg gtcctggtcc tgttccgggt cctggtcctg gtcctggtcc
     4201 tgtgccggga tctgagtccg gctcgggctc ggcaacaagc ctcgctcctg gtcctgttcc
     4261 gggtcctggt cccgttccgg gttcccgtcc cgggtcaggt cccggtcccg tgccgggtcc
     4321 tggtcctgtg ccgggttccg agtccggtcc gggctcggca acaagcctcg ctcctggtcc
     4381 tgttccgggt gctggtcccg ttccgggttc ccgtcccggg tcaggtcccg gtcctgtgcc
     4441 gggttccgag tccggctcgg gctcggcaac gggccttgcc cctggtgcag ttgccggtcc
     4501 cgggtcaggc cccggtcccg gtccgagttc tggtcctgtg ccgggttccg ggtccggctc
     4561 gggctgggca acgggcctcg ctcctagtcc tgttccgggt ccgagttctg gtcccgggtc
     4621 aggccccggc cccgttccgg gtcctggtcc tgtgccgggt tccgggtccg gctcgggctc
     4681 ggcaacaagc ctcgctcctg gtcctgttcc gggtcctggt cccgttccgg gttcccgtcc
     4741 cgggtcaggt cccggtcctg tgccgggttc cgagtccggc tcgggctcgg taacgggccc
     4801 cgcgcccggt tcagttcacg gtcccggctc cgggcccgct cccggttcag gcccggggtc
     4861 cggccccggg gccggacccg ctctcggtca gagcggcttg gcgtagcagc ggcttcgggg
     4921 ttcgaagcgg tagagaccga acttctccgt gggctcgtag ccggacgaga cgtacaggcc
     4981 gatcgcctcg ggctgcacga tgcccgtctc cagcaccatc cgcgtccgtc ccacggcgcg
     5041 cgcgtcgtcc tccagcgctt tgaggatgcg ccgtgccagt ccccgcccgc gcgcctcgcg
     5101 caccacgtac atccgcttga tctcggcgtc gccgtccgcg tagccctcgt cgttggcgtg
     5161 ctgtgtgcgc cagccgccgg acgccacggg gcggccctcg tcgtcgtacg cgatcagata
     5221 cagcccgtgc ggcggctcga acatggccgg atccagcggc gtgatgtcgc cctcgtcgcc
     5281 gtaccgctcc gcgtactcct cctgcacggc gtcgttgagc ttcctcgctt cggggtggtc
     5341 atagggcaca cggacgattc gcatgcctgc atcgtagggt gaccggaatg ccgaaggtga
     5401 cgacgatcaa cgtgaacggg ctgcgggccg cggccaggaa gggctaccgc gagtggctgg
     5461 cggccaccga cgcggacgtg gtctgcctcc aggaggtgcg tgccgagccg caccaactcc
     5521 ccgacgacgt gcgggcgccc gacggctggc acacggtgtt cgccccggcg gcggcgaagg
     5581 gccgcgccgg tgtcgcgctg ctcacccggc gtgaaccgga ccaggtccgg atcggcttcg
     5641 gcgcggagga gttcgaggac tccggccgct atgccgaggt ggacctgccg ggcatgaccg
     5701 tcgccagcct gtatctgccc tccggggacg tgggcacgga gcggcaggcg cagaaggagc
     5761 gcttcatggc cgccttcctc ccctatctgc gcgggctgcg cgagcgcgcc gcggcggacg
     5821 ggcgcgaggt gctcgtctgc ggcgactgga acatcgcgca ccaggaggcg gatctgaaga
     5881 actggcgcgg caaccgccgc aactccggct tcctgccgga ggagcgcgag tggctgtcgc
     5941 gggtcttcga cgcctccgac ggcggctacc acgacgtcgt acgccggctg cacccggacg
     6001 tcgagggccc gtactcgtgg tggtcgtacc gcgggcgtgc cttcgacaac gactcgggct
     6061 ggcgcatcga tctcgccgcg gcgacgcccg ggcttgcgga acgcgcggtc aaggcgtatg
     6121 tggagcgggc cgcctcacat gacgagcgct ggagcgatca cgcgccggtg agcgtggact
     6181 tcgtgccgta ggcggtacgg gagagcgatc gggaggccgg ggtggacatg ggcggggcgg
     6241 gcacggaacg cgcggacgtc gcgcagggtg cggaaggcgc ggacgtcgcg gaaggcacgg
     6301 acgtcgcgga aggcacggat gccgcggaca gtacggatgc cgcggagggc acggacgtcg
     6361 cgacggcgag gacgctgacc ttcgtcgtcg gcacggggcg gtgcggctcg accgcgctgt
     6421 cgcgggtgct gcgactccat cccgacgtgc tcagcgtcag cgagctcatc gcgtccgtcg
     6481 agccgggcgc gctgcccgaa cagcccctga cgggcaagga gttctggcag ctgctctcga
     6541 ccggcaggcc cttcgccgac cgcatggtgc gcgagggcac gccgctgccg gagcatctct
     6601 atccaggggt gccgggaggc cggttctcgg cggccggcgg cgggatcccc gcgctctgcc
     6661 tgaccaccct gccgcatctg accgacgacc cggacgccct ctacgacgcc ctggagccgg
     6721 tgctcgcggc ccgcgaccgt acgcccgtcg cggagcacta ccgggcgctg ttcgacgagt
     6781 tggcccggtg ggcgggcggc aggagcgccg tggtggagcg gtcgggcttc tcgctcgggt
     6841 acgtgccgcg gctgcgggcc gccttccccg aggcccgctt cgtccacctg caccgctacg
     6901 ggcccgactg cgcgctctcc atgagccggc acgccgggtt ccggctgctg cgcacggcgg
     6961 cgcaggccga ggcgggcagc cctgagcagg aactcgccgt ccgcctgggc gagttgacgg
     7021 cggacgactc gttcgacctg cggggcgtgc tggagcgtcc cgtgcccgtc gagcgcttcg
     7081 gcgagctgtg gagcggcatg gtcgccgacg gcatggaacg cctcgcgaag gtgccgcggg
     7141 cgctgctcgc gtcgctctcg tacgaggacc tgctcgacgc gccggaacgt gaactgaccg
     7201 cgctcgcccg gcacatcggg gtcgagccgc gcaccgactg gctgcgggcc gcggccgggc
     7261 tgctggacgg cgcccgccgt ggcgccgccg aggcgctgcc cgcggacgag ctggcccggc
     7321 tgcgggagag ctgtacgccc ggcatgcggg cactgggccg ggagggccac ggcgaccgcc
     7381 gggagggcca cggcgaccgc cgcgaccgcc acgacggtcc ggacggtcag tagccgctgc
     7441 gtgcgttgac ccgccgcggg tagtagcgct cgtcgccccg ccgttcgtac tccttccagc
     7501 gtggcgcgtc gcccgtcgga tggtcgccga ggacggtcac gcgctggccc ttgcggtact
     7561 cctggtagtc gttgatcgcc aggtgctgcg tcgcccggtt gtcccagatg gcgaccgcgc
     7621 ccggctccca gcggtaacgg cagttgaagc gcggcgactc ggagtgctcg aagaggtact
     7681 ggagcacggc gtcgctctcg ttgcgggtca gctgcgggat gtgcgaggtc cacatccgcg
     7741 tcacgtacag cgagcgccgt cccgtctccg gatgtacgcg cacgacgggg tgctcggcgg
     7801 agaacgtgcc gacttccggg gcctgtagca catgtacggc cgtgagcccg ttcagcatct
     7861 ccttgaacgg ctcggacagc gtctcgtacg cgaggtactg gttgctccac atcgtgtcgc
     7921 cgcccgactc ggggcaggtg acgaggtgga ggatcgaggc gaccggcggg ttggggctga
     7981 aggtgacgtc gatgtgccac tcgtccgcct tcccgccctt gtccgactcg atgagcgtca
     8041 cctcggggtg gctgtcgagc ttcggcagga aggggtgcac ctcgacctcg ccgaagcgcc
     8101 ggccgagcgc gacgtgcgcc tcgggggtca gcccggactg gcccgggatg aacaggacga
     8161 ggtggcgcag cagcaactcg tggatgctgt cgaagagttc gtcgtcgagt tcggtgaggt
     8221 cgatgccgtg cagctcggcg ccgatcgcgc cggagacggg gcgtacggac atcccgtgcg
     8281 ggagcttcgg gtcgtcggtg gcctgcgggc cggtcggggc gttcacggat tctccgttct
     8341 gcggggcgag tcgggggtga gccggggaac gagtcggggg aacgagtcgg gcgagtcggg
     8401 gtgccggtgg gagccgggcc gtcagcggga gccaagtccc ggtgcgtggc tgtgcgttcg
     8461 ggtacctctc actcctgcgg cacgcggtgg gcgcggggat cgggcagcag accgatctgg
     8521 tgcagccggt ccagcagcgt cagcgggcgc ggtcccagac cggccatgtt gtacgtgatg
     8581 gtgtgcagca gccgcgggtt ggcgcccgtg cagcgcaccg cgcggcggcc cagcacgcgc
     8641 ccgggccagc tgaggtcggt gaccatgcgg gcggcgttgt cgctcgtgcg ggcggcgtgg
     8701 gcgaggacgg gcagccgctc cagctcgtag ccgcgcaggg ccgcgtccac gacgtcccgg
     8761 gtcagcggct cacgggtgag gggtccgcgg gtccgcggct cacgcgcctc ggaccgctcc
     8821 ggcgaccccg atgcctccga cgggtccgat gcctccgata cttccgacgg ctccgactcc
     8881 aacggcccta cggcgggcgt gagttgctcc gcgagccgtt cggccagcga ggcggcgcac
     8941 gtgatcgcgg agttcatgcc ctgcgcggcc atcgggtgca ccgcgtaggc ggactctccg
     9001 acgagcgcga gccccggggc ggtcagccgc tcggcgagga accgggcgac ggggaagagc
     9061 tgccgggtgc ccgccgctgc cggtacggct tcggcgagcg gcgcgagcgc cggcacctca
     9121 cgtaccgcgt cggcgcccca gcgcgcgaat ccggcacggt ccagtccgcg cagctcgtcc
     9181 ggccgtgcct gcacatacag gcgtacgcgc ccgccgggca gcggatagac cagccgcagg
     9241 ccgcggtcgg tgaggtacgc cgagaagtcc tccgggcgca gcggcgggcc gtccagttcg
     9301 aacgagacca gccggtgcgg atagtcgctg cggctgccgc cgatgcccac ggcgcggcgc
     9361 aggcgggagc cgatgccgtc ggcggcgacg acgagcgggg cgtacacgtc ctgcgtcccg
     9421 tcgccgctgc ttgtcccgtc ggcgtccccg tcggcgtcgc tgtttccgtc ctcgccccgg
     9481 tcgcggtctc cgtcggcgtc cccgtccccg ttgccgtccc cgttgccgtt tacgtcctcg
     9541 tcccggtgcc gcccgccgtc gaggcgtacg ccgacgaccc gtcccgagtc gtcgcgcagc
     9601 gcttccacga cgcgtacgcc gcgccgtatc tcgacgccgg gccccagccc cgccgtcagc
     9661 gcttcgagga ctgccaggtg atcgtgtgcg agcaacgagc tgtcggcggg cggcagtcgg
     9721 ccgtagtcga gggtcatcac gggcgcgccc gcggggtcgc gtaccaccag ccgtcccaga
     9781 cgcagcgccc cgtcgcgggt caggagccgg tcggtgcccc agcggcgcag cgcacgcagc
     9841 gcgcccggtt gcagcacctc tcctttcgcg acgtggcgtg ggcttcgctg cttgtcgacg
     9901 accaggacac ggagcccgat cgcgtccagg gcgcgtgcgg aggcgaggcc accggccccg
     9961 gctccgcaca ccaccacgtc gtactcgccg tagccgtcgc tcatgacgca ccggccccct
    10021 tcgtacggcc ggaggccgcg gcgttccggc cgccggtccc ggtcccggac ctggtccggg
    10081 ccctggcacc gtccccgtcg ccctggttcc cggtcttggt cgcggtcgca gtcttggtcg
    10141 tagcctcggt atcggcctcg gtatcggcct cggtatcggc ctcggtatcg acttggtcgc
    10201 cgtcgactcg gtcgccgtcg ccggggccgt cgtcatggcc ctcggcgtcg agcgcggagc
    10261 ggaggcgggc gagggcacgc agcgccaggc ccgaggcgat gccgtcgtcg gcgtagcgcg
    10321 agcagtggcg gacgtactcg ttgacgggcg ctcccggcca actgccgtcg tcccgctgcc
    10381 attcggtgag ccggcgggcg gcccccgcga ccggttcgcc gtgcgggtcg gcgcccgcgg
    10441 tgagcagggc gtgcagcgcc caggcggtgt cctcgacggt gccgccgtcg tcgccgtggc
    10501 cgccgttccc ccgggcgccg gccgggtcct cggcgtccgg cgtcccccac gaaccgtcct
    10561 cggactgcgt acgcagcagc cgttcccgcg cccgcctcgc cgtctcgccg tcgccgagtc
    10621 ccgcgcggca gaaggtctcc agcaccacgg ccgtgcccgc ggtccgcccg cggtaccaca
    10681 tcgcctcgaa cgaaccgtcc tcgtgctgca cacggctcag ccagcgcaac gccctcacga
    10741 cacggcggtc ctggggccgc gcgccgtggt cgagcagcgt ccgtaccgcc ttggccgtca
    10801 tgtgcgggca cggcccgaac ccgcccggct tgctgccccg tacggccagg ctccacgaac
    10861 cggacgggtc ctgcatcgcc gtcagccact cgacgccccg ccgcgcgtgc tcgtcgcccg
    10921 ctccgcccgg catgctcagc agcgcggagg agacctccgc ggtctccagc gccatgggcc
    10981 agctgtacgc gctggagaag ccccagtagc cgggcgggca gccgagcgcc gcgaacggct
    11041 ccttctgctg ccgttcatgg aacatggcgc gggtcgcggc cagccgcggg tccgcggcgc
    11101 gaccggcctc cagcagcgcg gccgcagcga agctggacca ggtcacgtcg agcggcatca
    11161 ggtcccagcc gccgtcctcc ggccgcgcca tcgcgcgcaa ccgccgtgcc gacgcgcggg
    11221 tgatgtcggg cgccagcccg gagcgggtga cgccgagcga gatcaggccg gtcagccacg
    11281 ggtcggtgct gaactcgccc gtgctgccct cgcgttcgta cgcgtcacgc acgacacgga
    11341 gcgcctcggc ccgcgcacgg gcgttgaagg gagcgagcag tgggggcggc gcgcggtggg
    11401 cggactgcgc gagcgccatg ctcgcgaaga tcggcaggcg gagactgagc agccggcggg
    11461 ccgggccgcg cagcagcagg atttccagcg gcagcctcgg cagcgacgcc aggtcccccg
    11521 cgcccgaaag cgcgtcgaac tgccggacga gaccggccat cgtcggctcc gggagtgccc
    11581 cgggaccgcc gagccggtcg acgaagtccg cgcccgcacg tatcgccccc tccgcgcgct
    11641 cgggggcggt cagccgtagc gcggcggtgg ctgcggcggt ggccagcagc tcggtgggga
    11701 caccggccat cgcccaaccg ccgtcgggac gctgggagtt gagcaggcgg gtcacggcgg
    11761 cggcgccgag ctcgtccgcg tcgccgcggg cggtagggga ggcgtcgtcg ggggcgccgg
    11821 tgccgtcggg gccttgggcg tcgtcggtct cgccggtgcg atcggtgccg ccggtgccgc
    11881 cggtccggtc agtgccttcg gcgtggtgca gcgagatgag ggcggcggcc gtgttggcgg
    11941 gggagaagcg gtcgccgccc ggggcgaaga cgccgtccgg gcgttgcagg gcgaacagcg
    12001 cctcgcagcc cgcgtcgacc gatgtgcgta ccgccccggc gagttcgcgg ctcagcatga
    12061 tgtgacgtca cctcgcaggg actggtgctc ggttgccgcc gcgtgcgggg cctgcggcgc
    12121 tccgtccggg gacgtgccgg gggctccgcc ggcgcgggcc ccgggatccg ccgccttcgc
    12181 cgcgtccgcg tccgggtccg gatcggggaa ctcgtggcgc gagcgcatcc gcgactgcgc
    12241 gaccaggctc acggccagca gcggcaccac gaccgccagc gcgggcaccg gcccccagcc
    12301 gacggcgagc aacgcccccg ccagcagcat ccgttcggcc accaggacct cgtgcgcacg
    12361 cagggcgcgc cggggatcga gaacggcagg cgcggcggcc ggtgcgcccg gctccccacc
    12421 ggcggcgccc tcgcccacgg tctcgccacc gtcccggcgc acgtccgcgc cggtacgctc
    12481 gcccacgtcc cggccctcgc tcgtacgctc gcccatgccg tgacgcagca gcggcacgaa
    12541 ggccgccacg ccgcaggccg cggcgcacag cagcagcgcc agcgcaccgc tccccgggcc
    12601 gcccttgacg agaaggagcg cgggcacggc cgtcacgagg gcggccgtgt ggagcgccgt
    12661 ggccgtacgg accgcggcgc gcaccccgtg ccgcaccggt acggtgcggc agccgccccg
    12721 gcggtcgccc tccacgtcgc gcaacgtgcc caccaggttc gacgcggtgt cctgagcgca
    12781 gaacaccccc gcgaacagca ggacttgcca cgacggcagc tcggccacgg tcatcgcgcc
    12841 gaagatcacg gtggtcgcgg tcagcgctcc ccgtacggcg ttgcccgtca gcccgcggcc
    12901 cttcagcagc ctgctgtagg cgacgattcc gagcatggcc acggcgaaga gcaccacggt
    12961 ccgccagttg acggtcgcgg cggccaccgc ggccgccgcc gcgcatccga tgccgcacgt
    13021 cagcgccgca cgcggcccca accggccgga cggcagcgga cgttggggct tgctgatcgc
    13081 atccagagcg cggtcgaacc agtcgccgat gtagtgcccg ctgacccagc ccagggtggg
    13141 ggcggcccat gccacgagca gccgcccggc gtccggatac ccgtccgcgg cggtgccctc
    13201 cgtgctgttc agcgccgcgc ccgcgaggcc gaccagcccg ggataggcga gggtgtaggg
    13261 gcgccaggtc tcgatgtgcg ccttgccggt gcgggcgcag gcccgtagcg cgcgctccac
    13321 cggcaggtct cccggcgcgc gcccttcacg ggccgcggtc gccggtatgt gctcgacttc
    13381 gtgtgccgtc atgagtccct gtccgtggac ggccgcgtgt tcacggcacg tcaccgccgt
    13441 cgccgtccgt gccgtgcgtg ccgccgctcg tacggtcgcc gcccgaaccg ccctcgtcat
    13501 gggggcgttc gccgccgaac ttgcccgcaa gctccgcgaa cgcgtcgttc gcctcccgct
    13561 cggcgacggt cacccgcacg ccctcgccgg gctttccgca caccagcaca ccgtggtccg
    13621 cgcagaactg ggtgaagtgc tccacgccct ccgtcatcgg cagccacagg aagttggcct
    13681 ggctcggccg cacctcccag cccagctcca gcagcctgcc gtagagccgt tcacgctcgc
    13741 cgacggtcac ctcgcagcgg cgcctgaact ccttctcctc cgcgagcgcc gcctgcgccg
    13801 cggcctgcgc ggtgttgctc accctgatga acggctggag gccgcgcagc ggtcccagcg
    13861 tccgcggatg cccgacgacg tagccgacgc gcagcccgag caggccgtac gacttggaga
    13921 acgtacggac cacacacacc cgttcgtcgt cccggtagag cgtgatgccg tcggcggcga
    13981 agtcgtcgcg tacgaaatcc cggtacgcct cgtcgacgac caccgtcacg tgggacggca
    14041 gccgggccag gaagcgttcg gcgtcggagt gcctcagggc ggtgccggtg gggttgttgg
    14101 ggtggcacag cacgaccatg cgggtctggt cggtgacggc gtcggccatc gcgtcgaggt
    14161 cgtgggagtc gtcgtcgcgc agcggcaccc ggaccgtggc ggagcccgcg ttggccgcga
    14221 gcatcggata cgcctcccac gacggccacg cgtgcaccgt cgcggagccc gctccggcag
    14281 ccgaacccgg ggaaccggcg gaaccggcgg aaccggtcga atccgcggaa cccgccggac
    14341 cggccgcacc ggccgcaccc ggtccggtca gcgcgctgaa gagctgttgc agcagggcgg
    14401 cggagccggg gccgacgagg acgtcggcgg cgggcacgcc cagccgttcg gcgatgcggc
    14461 ccgtcagacc cgtggcgagt gcgtcgttcg tacggtgcga gtcggcggcg gcctcgtgaa
    14521 ccgcccgcag aacgcccgga ctcggtggga agaacgtctc gttcagcgac atctggtgca
    14581 ggacgggagc agaaccgata accggctgca ttctgttcca gccgtcttct tcgtccattt
    14641 ccgtccaatc cgcagagagt cctcggaaca attccgccgg gtgcctgcgc gtggggcgcc
    14701 gcgaaggggg atcctgattc tgacccctga acgggtcacc gtccaacgtc agttggtgcc
    14761 ccttcggacc aggcatggga cttccttcgc gcaattccct tatcgggtcc cggagtctcc
    14821 gcgcgttgcg cccgtatcgg ggtcccgcgg gcatacggac gggcctcgcg catttcctgc
    14881 tgagcggcgc aggcgggcgc gtgaggggcg gttcgggcgc gcggccgctg cccgcaaacg
    14941 gaggcggcat gaccgtaatt gcccgtacgc gcgggtagcc ggttgctgac gcctgacagc
    15001 tgacagatgc ggatctctgt catctgtcat ccgtcgtctg tcatctgtca gacgtcatct
    15061 gaccgctgat atctgaccgc tgatacgcgt cagctgtcat cggtcatcgg tcatcggtca
    15121 tcggccatcg gtcagccgtc agcggcggcc gtgcccgtgc ccgtgcccgg ggggtcggct
    15181 gtcgtcggtg ggccgggctc gcgctgggcg atccactgct cgacctccgc ccgtacccgc
    15241 cggtccaggg cgagccccag ctccgcctcg aagacctgct tggcgagcgg gcgcagttgc
    15301 ctcagcagat cgtcgaggca ctccgcgtcg agcccttcgg gagcggcgtc cgcctgctcc
    15361 ttcggcagca gatgcgtacg gaagaggtgc acgaagacgt cggcgatccc ctcgctctgc
    15421 ttgcgcagtt cacgtccgga ggcgagtacg gcggcgagcg ggatgccctt cttcaccagt
    15481 tccgacgacg cgtccagcag gcggcggctg acgtgtacga actcgtcgcc gtcgacggcg
    15541 atgtagccga tgtcgagcgc ggcggccagg ttctcgacgg tgacctcgcc ctggtagtag
    15601 tcggccagtt cctcgggagt cagccggatc ggcgtctcct cggcgaacag cgaggtgatc
    15661 atcgagcttt cgaggccgag cagttcggcg gtcctctgcg agtcgcgtcc gctctcgaag
    15721 gcgccgagca gatcgacgat tccgccgagg gtgtgcccgc ggttcagcag cccggcgatg
    15781 gtgtgcagcc gcgccaggtg atgctcgtcg taccaggcga tacggccctc acggcggggc
    15841 ggcggcagca gcttccgctc gcggtagaag cgcagggtgc gggtggtgat cccggccagc
    15901 tcggccagtt cggcggcacg gaactcgcgc acggcgggcg ccgcgggtgc gggggctgcg
    15961 tccggtgcgg ccggctgctc cgcgtcctgt gcccgggcct gcggcgcctg agcacggccc
    16021 gcatctgcac ccgtgctcgg acccgtactt gagcccgtgc ctgcacccgt actcggaccc
    16081 gtgcccccgc ctgcacccgc gctgccgtcg gcctcggcgt gaccggcgcc gcccggacca
    16141 tcgggccccg cgccccgcgc tcgctctctg tcctcggtca ccgtggcagc ttaaccaggg
    16201 gcgtcacgct tacgtacgtc ccgtccccgt cccctcctcc gcccctcggc ccccgccccc
    16261 tcggtccccg tccgcaccgc agtcgcccgg cgccgcccgc cgtcgaccgc gcccgcccgc
    16321 agtcgcccgc accgcccggc gccgcccgcg cccgcctgcc gccggaacgc gtcgcgcgac
    16381 cgcgtcccac cgaccgcgtc ccaccgaccg cgtcgtgcaa ccgccggtaa cttccgttgc
    16441 gcgaccccta cccatcggta tcggtctgcc ttacgctccc aaccgtgcca gtaatcactg
    16501 gcgcagtaac cggcgcggtg accgtcgcag cggccgacgt ggtcggccgg cgcggtgtcc
    16561 ggccaggtga ctgcgcggtg cctggcgaag agcagctggc gaagcagacc ccgggaggcg
    16621 gcggatggca gccgagcgcg agcacgagca cgtaagggtg gcggtgatcg gatccggatt
    16681 cggcggcctg ggggccgccg tgcggctgcg ccgcgccgga gtcaccgact tcgtcgtcct
    16741 cgaacgccgg gaggcggtcg gaggcacctg gcacgacaac acctatccgg gatgcgcgtg
    16801 cgacgtcccg tcgcacctgt actccttctc cttcgcgccc aaccccgact ggccgcgggc
    16861 cttttcgggg cagaagcaca tccgcgccta tctggaggac gtggccgaca acttcgggct
    16921 gcggcagcac atccggttca gctccgaggt ggagctgatg agctgggacc cggaggagct
    16981 gcactggagc atcaccaccg cccgagggga ccgtctcagc gcggacttcg tcgtcaacgc
    17041 caccggtccg ctctccgacg cgaagatccc cgacatcccg ggcctggagg gcttcggcgg
    17101 caaggtcttc cacaccgccc gctgggatca cgactacgac ctgcgcggca agcgcgtcgc
    17161 cgtcatcggc acgggcgcct ccgcgatcca ggtcgtaccc gcgatccagc cggaggtcga
    17221 acggctcacc ctcttccagc gcaccccggc atgggtgatg cccagggccg accgcgagat
    17281 cagcacgctg gagcgcaggc tgcacgccaa ggtgcccgcg acgggctatc tgaggcgtca
    17341 gatcctctgg ggcataaggg agttgcaggt ctcggcgttc gccaagcacc cgaagatgct
    17401 gggcctcatc gaggggctcg cgaccagcca catgaagcgc gccgtgaagg accccgtgat
    17461 gcggcgcaag ctcacaccgc agtaccgaat cggctgcaag cgcatcctgc tgtccaacga
    17521 ctactatccg gcgctcgccc ggcccaacac cgagctggtg gcgtccggtc tgaaggaggt
    17581 ccggggcaac accctcgtgg cgtcggacgg ttcggaggcc gaggtcgacg cgatcgtctt
    17641 cggtacgggc ttccacgtca cggacatgcc gatcgcgcag cgcgtcaagg gcgccgacgg
    17701 caccacgctg gccgagtcct ggtcggaggg gatggaggcg ctgcgcggct gttcggccag
    17761 cggcttcccc aacttcatga ccgtcatcgg gcccaacacc ggcctgggca acagctcgat
    17821 gatcctcatc atcgaggcgc agctgaacta catggtcgac tacgtcaaga agctggagac
    17881 gctgggcggc gacgcgggca aggtcgcctt cgacgcccgg cccgaggcgg tcacggcctg
    17941 gaacggccac atccaggacc gcatgcggcg cagcgtgtgg aacacgggct gcgacagctg
    18001 gtacctcgac gccaacggcc ggaacacgac ggtgtggccg ggcaccaccg ccgagttccg
    18061 caaggtcacc agggaggtgc ggctggagga gtacgaggtg ctgcgccggc cggcggcgcg
    18121 cggtacggcg ggctccggtg ccgagggctc cggtgccgag gcttccgata ccggggcttc
    18181 cggcaccccg gggtcccgtg ccgcgggatc ccgtacggct tcgcccggcg cgacccgcgc
    18241 cacccgcgcc gctcgcggca agtccgggcg cagcaccgcc acgtccgcct tccactcggc
    18301 tgaggaggcc tgatggcgcg cctgaccgcg tcctggggca ggacaccggg accgtacgat
    18361 ccgccgccgc ccgcaaggga gttgacggcc acctccgccg acggcgccag gctccacgtg
    18421 gaggtgcacg gggacgcgaa ggacccggcg gtggtgctga tacacggctg gacctgttcg
    18481 acggccttct gggcggcggt gatacgggag ctgacggcca gcggtcaccg ggtgatcgcg
    18541 tacgaccagc gcggccacgg ccgttcgccc ggcaccggcg cgcgcaccta cgggcccgac
    18601 tcgctcgccg acgacctgtg cgccgtgctg gaggcggcgc tcgaaccggg cgaacgagca
    18661 gtgctgtgcg ggcactccat gggcgcgatg acgctgatag ccgccgccgg acgccccgcc
    18721 ctcgaagcgc gggccgcggc tgtgctgctg tgcaacacgg gcgcccgccg gctgatggcc
    18781 tcggcgcgcg tgatccccct gcggtccgaa ccggcccgcg tacgggcgca ccgcttgctg
    18841 ctgctgtcca ggctgccgct cgggccggtg tcgccactga cgaggaaggc gctcaagtac
    18901 gggacgatgg gcccggattc gccgcccgag caggtcgacg ccatggcccg catcgtgcac
    18961 gcctgccggc cgcgcgaacg cggggcgtgg ggcgcggtgc tctcgaagct cgacatctcg
    19021 ggccgggtcc gcgccctcac cccgccgacc gaggtgatcg cgggcacctc cgaccggctg
    19081 actccgcccg ccctcgcccg cgagatcgcc gacgcgctgc cccgctgcac cggcctgcac
    19141 gagctgccgc ggcgcgggca catggcgccg gtggagacgt cgtcggaggt gagcgaggtg
    19201 ctgcgccggc tcgtacggga gcacctcatg gagaccgcgg ccaccccgag ccggaagagc
    19261 ccggggaccc ggcaggccca gcagtcaggg aagccccggc caacgcagaa gtcccagcga
    19321 acgcagaagt cccagcgaac gcagaagtcc cagcgaacac agcaaacgca gcgaacacag
    19381 caaacgcaga gcatgaccga gagggaggag acgccgtgag ccgtcgtcgg agcctggagg
    19441 gccaggtcgc ggtcgtcacc ggagccgccc gcggcgtggg cgagctgctg gcgcggaaac
    19501 tctccgcgcg cggcgcgaag atcgcgctga tcggcctgga gccggacgag ttgaagaagg
    19561 tgagcgagtc gctgcgtacg gagtccgcgt actggcacgg cgacgtcacc gacgacgacg
    19621 cgatgaggcg catcgcggac gaggtcggtg agcgcttcgg caaggtcgac gtggcggtgg
    19681 ccaacgcggg cgtcgccagc ggcggtccgt tcaccgactc cgacgcggag tcgtggcggc
    19741 gcgtcataga ggtcaacctc ctcggcggtg cggcgaccgc ccgcgccttc ctgccccggc
    19801 tgatcgcctc ccgcggctac ttcctccaga tcgcctcgct cgccgcgatc actcccgctc
    19861 cgatgatgag cgcgtactgc gcgtccaagt cgggcgtcga ggccttcgct cactgcttga
    19921 gcgcggaggt cggacacaag ggcgtacgcg tcggcgtcgg ctacctctcc tggaccgaca
    19981 ccgacatggt gcgcggcgcg gacgaggacg acgtcatgcg cgacctgcgt aaacggctgc
    20041 cgtggccggc gaaccgcaca tatccgctgg ggccgtccgt cgaccggctc gtggcgggca
    20101 tcgagcgccg ctcccgccac gtgtacgggc agtggtggct gcgcggcatg caggggatcc
    20161 gcggttatct gccgcccgtc atcggcacgg tgggccagcg cgagatgcgc cgcttcgagc
    20221 cgcgcctcgc ggagagcggc acccgcacgg gcctggtggg cgcgggcgga gcggcggacg
    20281 agggcgagcg cgcggcccgc ctctgacagc cgtcgcgcgg ccgggccccg gcaatcgtca
    20341 cgcgggacgc gccccggacg cgggcccttg cccgccccgg gcgcgttccg ccccggcctg
    20401 ttcggatccg aaccgtccga atccggcccg gcgcccaccc gacgccgctc gggtgtcaac
    20461 gacgggcccg gcggcgcccg ttacgtggct gatccgctgg ggttcacttc ccggggacct
    20521 attccggtgc ccggctgtac gcctccagcg tctccttcgc cgtcgaggcg tcctggaaga
    20581 ccagctccca cggacccgtg ttgacgtcca tgtccttgcc gaagccgacc cacttgccga
    20641 ccatgcgccg tcccgtgggc tcgacgagga gctgaatcgc cccgtgatag cgggcgcccc
    20701 ggtagtagcc gtccgtcgct gtctgctcgg cccacgtccc agtgaccacg ttgcggtcga
    20761 tcctgaggtc cagtgacagg ggcgagtccg gattcagcga agcgccctcc aaggagtgcc
    20821 ccttcaactg gctgccgtgc tggaggagca ccacgaagtg ggcgcccttg aaggtcgctt
    20881 cacggcccga cgagaagaac tcgtaccggc tgagccagat acccgagtag ttctccgcgg
    20941 ctgtgctcgg cgcggagcgc ggcgcgccga cggcggctgt gacgccgtct gtgctgtggt
    21001 ccatgtcgtg cccgcctctg ccgtcacttg tcacccgtgc catggggacg ggcacttgga
    21061 agcctagcga ctcgacggga agccccgtaa cgctctccag cgcacgcgtg tacagggggc
    21121 gtggacggcg gatcctgcct gattcccagc gctgtacgag ccgtttggac gcgccgttgg
    21181 ggtctcctgc tgcgtgtcct gcccgctgta gggctctggc caggtcgtcc tggcttaagc
    21241 gcaggccgat acgcactgcg cgcagtgtgt cgttgggggt cacggaggcg gcgtcagatg
    21301 cagtggtcat gactccatac tgtcccgaaa tgccgttctg tgacgcctgt atgacgcccc
    21361 gtgaaaggtg tctcttcgac gtccgccatg tcgtcgtaca ggtcggccga caggccgagc
    21421 atgagggaca tggcagacga agagaaggca gggggatgcg gggtgtgcgc ggctctgctc
    21481 aagcaggtgg acaaggcggt cggtgagtac gaccggagtg ccgaggtcga tgcgcgggtg
    21541 aagctgcggc ggcacatgag gcagatccat ggtcgggaac tcccgttggc gtggtgactc
    21601 ctcagaacgc tccccgttcc cggcactcgg tagctgtgca ccggacggca gcagttgccc
    21661 ggttcgccgg tctcccttgg cttgcttggt cctcgacggc aaggcccttg ccctgttctc
    21721 gatctccgtc accggcccga ccgatcacga aagaccggaa actctggacg ggcccggaca
    21781 agaccccggc cgggccggct gtccgccccc aactcgcccg ccccacaccc ccgttcaccc
    21841 cctcggcggc agtggcgggc ggctcaggtc cgggacgcgt gcgtagtccg gcgggacggc
    21901 ggccgggtgt cgctccagga gtgcgagtgc cgtgcgtacg gccttctcca gcaccgaggg
    21961 ccgcccctcc gcccactcca gcggcgaacg caccgcctcg atgtccggtg cgatgccgtg
    22021 gttctccacc gaccatccgt acgcgtcgaa ccaggccg
//
