LOCUS       NZ_JAASAG010000009     10807 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. HNM0575 scfid9, whole genome shotgun sequence.
ACCESSION   NZ_JAASAG010000009
VERSION     NZ_JAASAG010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. HNM0575
  ORGANISM  Streptomyces sp. HNM0575
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 365808)
  AUTHORS   Xiao,K.
  TITLE     New actinomycetes from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 365808)
  AUTHORS   Xiao,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-MAR-2020) College of Tropical Crops Hainan University,
            Hainan University, Renmin Avenue, HaiKou, HaiNan 570100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2018
            Assembly Method                   :: SOAPdenovo v. 1.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012726265.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 05:29:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,992
            CDSs (total)                      :: 5,923
            Genes (coding)                    :: 5,797
            CDSs (with protein)               :: 5,797
            Genes (RNA)                       :: 69
            rRNAs                             :: 5, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 126
            CDSs (without protein)            :: 126
            Pseudo Genes (ambiguous residues) :: 0 of 126
            Pseudo Genes (frameshifted)       :: 15 of 126
            Pseudo Genes (incomplete)         :: 115 of 126
            Pseudo Genes (internal stop)      :: 5 of 126
            Pseudo Genes (multiple problems)  :: 8 of 126
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 277619
            Orig. end                         :: 288426
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAASAG010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10807
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10807
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10807
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5807](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5807
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            387..1163
                     /locus_tag="HCC61_RS22130"
                     /old_locus_tag="HCC61_22125"
     CDS             387..1163
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345657.1"
                     /locus_tag="HCC61_RS22130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22125"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_169138151.1"
                     /transl_table=11
                     /translation="MHLGYGDREVISGLTADVPPGAVTMIVGPNACGKSTLLRALARLL
                     SPTAGTVRLDGRSLGELPTKQIATVLGILPQAPVAPEGITVADLVGRGRYPHQDWFRRR
                     TAEDDTAVARAMLATDVLELAERPVGELSGGQRQRVWIAMALAQGTDILLLDEPTTFLD
                     VSHQLDVLDLLTDLNRAAATTVVVVLHDLNLACRYADHLVVMKDGGIVAEGRPSDVVTE
                     ELVTEVFGMRCSVVTDPSSHTPMIVPIGRHHVVAGD"
     misc_feature    1204..1222
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.86"
                     /tool="antismash"
     misc_feature    complement(1209..1227)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 25.56"
                     /tool="antismash"
     gene            1228..2295
                     /locus_tag="HCC61_RS22135"
                     /old_locus_tag="HCC61_22130"
     CDS             1228..2295
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018509681.1"
                     /locus_tag="HCC61_RS22135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22130"
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_169137954.1"
                     /transl_table=11
                     /translation="MTPVAHPPRKPSQVPAPAPVSFRRPTAPRRPGVGTRRTTTAALAL
                     GALLLGLTGCGTTGDGNGDAAGGRTVTTKFGEVSVPEKPKRVVALGWGDAETALALGVQ
                     PVAQSDWLAFGGDGVGPWAEGRYTKSPKKIGTLEPEYEKIAGLRPDLILDTKSSGTRER
                     YDTLKKIAPTVGVPEGGDQYQISWEQQTKLVAKALGREERARRLIARNDRAFAEAVKAH
                     PEFKGTTVTLGSRTADAYGAYVRGGGRVDFVERLGFRNNPKVEARAGKAFSVPVARENL
                     DLLDADLTVVSPIGVSADKVREDPLFRAVPSVRKGHSVVFGDKKLSSAFATDSVLSTPY
                     ALKKVVPVFADALKK"
     gene            2403..3257
                     /locus_tag="HCC61_RS22140"
                     /old_locus_tag="HCC61_22135"
     CDS             2403..3257
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00027.1"
                     /locus_tag="HCC61_RS22140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22135"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_169137956.1"
                     /transl_table=11
                     /translation="MTQSPTHGVALTAVAMANERRVETAREDRLVDDPLAGAFVDAAAP
                     ADGPFPWLQDGGTLSDLCPAMGDYVALRTRLFDDWTLRAVCEEGVRQVVLPAAGLDARA
                     YRLSWPGDVRLFEIDFPELIAFKQETLAAVGARASCERTAVRADLDDDWESPLLDGGFR
                     PEQPSLWLVEGLLMYLADDDGLLSRITALAAPGSRLIADHAYPEALRSEAFAAGTQTLA
                     ANGSAFGSTVTDPEAWLAGHGWSAALAEPSDLVGGTGRALPAVLDPAVPDSPVFWFALG
                     RRG"
     gene            3366..3995
                     /locus_tag="HCC61_RS22145"
                     /old_locus_tag="HCC61_22140"
     CDS             3366..3995
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453975.1"
                     /locus_tag="HCC61_RS22145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22140"
                     /product="DUF1345 domain-containing protein"
                     /protein_id="WP_169137958.1"
                     /transl_table=11
                     /translation="MNSAWLPISAVTRLAAAAVVGVAIGTVVGFSVDTPLGILAAIAAT
                     ETCFVVAGWTVLWPMDADSTRRNAGREDFRPLTEELVVIAAALCGLGGIVVLLLGNSDT
                     SHAAAALAGVFMAWAALHLMYATRYAYLYYVDAAGGIDFNSDQPPAYRDFFYFSYNLSM
                     TYQVSDTDVSNSAIRAMALRHCLLSYAFGTSILATAINLVVGIVSS"
     gene            complement(4067..4447)
                     /locus_tag="HCC61_RS22150"
                     /old_locus_tag="HCC61_22145"
     CDS             complement(4067..4447)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979905.1"
                     /locus_tag="HCC61_RS22150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22145"
                     /product="thioesterase"
                     /protein_id="WP_169137960.1"
                     /transl_table=11
                     /translation="MRYEVTEADTAMAIGSGDVPVLATPRLITWMEAETVRSATPLVAD
                     GQTTVGTAVRVDHRRATPVGGVVEVTAELPATAAGRKLTFAVRAVDDCGELVAAGEMDR
                     AIVDRQRFLPVTSASSGHSLAG"
     misc_feature    4710..4725
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.95"
                     /tool="antismash"
     misc_feature    complement(4713..4728)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.86"
                     /tool="antismash"
     gene            5001..5807
                     /locus_tag="HCC61_RS22155"
                     /old_locus_tag="HCC61_22150"
     CDS             5001..5807
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018834463.1"
                     /locus_tag="HCC61_RS22155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22150"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_169137962.1"
                     /sec_met_domain="Linocin_M18 (E-value: 1.4e-87, bitscore:
                     287.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLHRELAPVSDAAWADLEAEARRTFQRNVAARRLVDVPEPAGV
                     KLAALSTGHLDTIQPPADGVFADLRRAQPLVQLRVPFSVSRAQVDSVEQGAKDADWGPV
                     KEAARRLALSEDRAVFEGYGAAAIRGIRAESSNAPLALPAQAREYPEVVSRAVSSLRLA
                     GVEGPYALAMSADAFTTVSEASDNGYPIHDHLRQVVGGEIVWAPAIDGAFLLTTRGGDF
                     ELGIGQDVSVGYLSHDSAEVELYLQESFTFLVFTAEAGVALVSGHQ"
     gene            complement(5791..6867)
                     /locus_tag="HCC61_RS22160"
                     /old_locus_tag="HCC61_22155"
     CDS             complement(5791..6867)
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432629.1"
                     /locus_tag="HCC61_RS22160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22155"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_169137964.1"
                     /transl_table=11
                     /translation="MAHQGQPQHVLAPPAKAAIFLVVTVRAGAEEDARDLLSDLAGLTR
                     AVGFRNPEGELSSVVGVGAELWDRLYDAPRPAGLHPFRTVAGAVHTAVSTPGDLLFHLR
                     AGRMDLCFELARQIMDRLAGCVDVADEVHGFRYFDERDLLGFVDGTESPSGPSALAVVH
                     IGDEDPAYTGGSYVVVQKYLHDLDAWGALPIEEQEQAIGRRKLSDIELPDADKASNSHV
                     ALNTIVDPDGTEHKIVRDNMPFGAVGDREFGTYFIGYAVNPDVIERMLRNMFIGDPPGN
                     HDRILDFSTAVTGGLFYVPTTEFLDDQPPRPTVSAATAAATATATAAATDATAEPPRPD
                     GSLEIGSLRGAGRVTGDR"
     misc_feature    complement(6877..6897)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.73"
                     /tool="antismash"
     gene            complement(7084..8301)
                     /locus_tag="HCC61_RS22165"
                     /old_locus_tag="HCC61_22160"
     CDS             complement(7084..8301)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081774.1"
                     /locus_tag="HCC61_RS22165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22160"
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_169137966.1"
                     /transl_table=11
                     /translation="MTRNGLADLAAWASDRLPRLIDDAHATVLDRIEIYRDGEPVSSED
                     LRRSIAHNLRAMVGAIGHPQDSLDLSAPRETGHRRAHQGVPLPEVLQAYRISFATLWDA
                     LVEHARRGQRPSMADTLLTAASMIWQLTDEHALALTEAYRAATAELLLAQQQRRSALVE
                     ALLTGGPGPEVGPWEAANLLGLPPDAQVVVVAAETRGLAEESLPGIERRLAAHGIVSGW
                     RLTPALQLGIVSLHSDVRETALAVLREAAGARTGVSPPYQSLADSPRALQLARTALATL
                     PAGRAEVRMFSPSPLAALMACDPGEGRRLAKEVLGAVLELSPDDRAVLLDTLNAYLDHD
                     GSSERAAEVLYCHPNTVRYRLRRVHELTGRSLSDPRGIAELATAADALSLSSNVLLQNG
                     HSSRSQ"
     misc_feature    complement(8382..8397)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            complement(8786..10069)
                     /locus_tag="HCC61_RS22170"
                     /old_locus_tag="HCC61_22165"
     CDS             complement(8786..10069)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018893420.1"
                     /locus_tag="HCC61_RS22170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_22165"
                     /product="MFS transporter"
                     /protein_id="WP_169137968.1"
                     /transl_table=11
                     /translation="MPVSNATRGWLPVASALYVAGWGASQFAPLAVVYRVREGWAALAV
                     AAMFTLYLVGLVPGLLLGGRIADRYGRRRAVRGALAMSSAASTALAAAVVTEDAVYPSR
                     LATGLAAGIVLSAGATWLEEISEARGQDAGNRRALYATGAGFASGALAAGVVAEWLPQP
                     MVLPCLLHGVLVLLVFFATRGSPDTTPSREDGTAPPRPPRMRWTIVTHPRFVLVVLPAS
                     PAAFAAATVAYVVLPPLVIDQVHGHAPMFSGLVVGVTIATGVAVQPLATWLDQAGSARS
                     TLVAMATVVVGLLAGAVAVYLDSPLLVLPAAVVLGAGYGLTLASGLKEIERLAHGPALP
                     TASSVYQGATHSGFLAPLLLAMSAGAAPYPALLVGLAAVGVLFLGITAFYSRRHLPAVM
                     GAAQEPPSAPEPGPSERARAERSATRDE"
     misc_feature    complement(10357..10372)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.6"
                     /tool="antismash"
ORIGIN
        1 gccgtgcagc gcagcagggt cgcgctgctg gcatgcgcgg tggggctgtc cgccgcggcg
       61 acggcggccg cggggccggt ggcgttcgtg gcgttcgtat cggccccgat cgcccgccgc
      121 ctggcaccct cgcgcggccc ggcgctgacg cactcggcgc tgctgggctc gctcatcgtc
      181 ctgctcgccg acttcgtggc gcagcatctg ctcggggaga cgcagttccc ggtgggcgtg
      241 gtgacgagcg tgatcggggc gccgtatctg ctgtggctgc tggcgcgtac gaaccgggtg
      301 gggaaaggcg gttgacggtg gcggtgtacg cgaaggacgg gcggcaggtc gagggaggtg
      361 cccaacacac cctgggcaca cgggagatgc acctcggcta cggcgaccgc gaggtgatct
      421 cgggcctgac ggcggacgtg ccgccgggcg cggtgacgat gatcgtcggg cccaacgcct
      481 gtggaaagtc aacgctgttg cgcgcgctgg cccggctgct gtcccccacg gccggcaccg
      541 tacggctgga cggccggagc ctcggcgaac tgccgacgaa gcagatcgcg acggtgctcg
      601 gcatcctgcc gcaggccccg gtggcccccg agggcatcac ggtcgccgac ctggtcggcc
      661 gcggccgcta tccgcaccag gactggttcc gcaggcggac ggccgaggac gacacggccg
      721 tcgcgcgcgc catgctggca acggacgtgc tggagctggc ggagcgcccg gtgggcgaac
      781 tctccggcgg acagcggcag cgggtgtgga tcgccatggc actcgcccag ggcaccgaca
      841 tcctgctgct ggacgagccg accacgttcc tggacgtgag ccaccaactc gacgtgctgg
      901 acctgctgac cgatctgaac cgcgcggccg ccaccacggt cgtcgtggtg ctgcacgacc
      961 tcaacctcgc ctgccggtac gccgatcacc tcgtcgtgat gaaggacggc ggcatcgtcg
     1021 cggagggccg gccgtcggac gtcgtgaccg aggagctggt caccgaagtc ttcggcatgc
     1081 gctgctcggt ggtcaccgac ccgtcgtcgc acacaccgat gatcgtgccg atcgggcggc
     1141 accacgtggt cgccggggac tgagaacggc cgtcccgtcc gcacgcgagc agccccctct
     1201 cacttaactt aggctaacct aaccaagatg acacccgttg ctcatccccc gcgcaagccg
     1261 agccaggtcc ccgcgccggc accggtctcc ttccgccgcc cgactgcccc gcgccgcccg
     1321 ggagttggga cgcgccgcac caccactgcc gcactcgccc tgggtgccct gctcctgggg
     1381 ctcaccggct gcggcaccac gggtgacggg aacggagacg ccgcgggcgg ccgtacggtc
     1441 accacgaagt tcggagaggt ctcggtgccg gagaagccga agcgcgtggt cgctctgggc
     1501 tggggagacg ccgagaccgc actggcgctg ggggtgcagc cggtcgcgca gagcgactgg
     1561 ctggccttcg gcggcgacgg cgtcggcccc tgggccgagg gacgctacac gaagagcccg
     1621 aagaagatcg gcacgctgga gccggagtac gagaagatcg ccggcctccg gccggacctg
     1681 atcctggaca ccaagtccag tggcaccagg gagcgttacg acaccctgaa gaagatcgcg
     1741 ccgaccgtgg gcgtgcccga gggcggcgac cagtaccaga tcagctggga gcagcagacc
     1801 aagctggtcg ccaaggcact cggccgcgag gagcgcgccc gccgcctcat cgcccggaac
     1861 gaccgcgcgt tcgccgaggc ggtcaaggcg cacccggagt tcaagggcac gaccgtcacg
     1921 ctggggtcgc gtacggccga cgcctacggc gcgtacgtac gcggcggcgg acgcgtcgac
     1981 ttcgtcgaac gcctgggctt ccgcaacaac ccgaaggtcg aggccagggc ggggaaggcc
     2041 ttctcggtgc cggtcgcccg cgagaacctc gacctgctcg acgccgacct caccgtcgtc
     2101 tccccgatcg gcgtctccgc ggacaaggtc cgtgaggacc cgctcttccg cgccgttccg
     2161 tcggtgcgca agggccactc cgtggtcttc ggcgacaaga agctcagctc cgccttcgcc
     2221 acggactcgg tgctctccac cccgtacgcg ctgaagaagg tcgtcccggt cttcgcggac
     2281 gccctgaaga agtaggcgtg cccgctgcgc cgcccgcgct gccggtgctg cgtcgtcgcc
     2341 gtccctccgc gccccggccc tcgccgtcgc gcacccccgc cgcccgtacc cgaggagcga
     2401 agatgaccca atcccccacg cacggcgtcg cgttgacggc cgtcgccatg gcgaacgagc
     2461 ggcgcgtcga gacggcgcgc gaggaccgac tggtcgacga tccgctggcg ggcgccttcg
     2521 tcgacgccgc ggcaccggcg gacgggccct tcccatggct ccaggacggc ggcacgctca
     2581 gcgacctctg ccccgcgatg ggcgactacg tcgcgctgcg cacccggctg ttcgacgact
     2641 ggacgctgcg tgcggtatgc gaggagggcg tacgccaagt cgtgctgccc gccgcggggt
     2701 tggacgcgcg cgcctatcgg ctgtcctggc ccggcgacgt ccggctgttc gagatcgact
     2761 tcccggagct gatcgccttc aagcaggaga cactggccgc cgtcggcgcc cgggcgtcct
     2821 gcgaacgcac ggcggtccgc gccgacttgg acgacgactg ggaatcgccg ctgctggacg
     2881 gcgggttccg gccggaacag ccctcactgt ggctggtcga ggggctgctg atgtacctcg
     2941 ccgacgacga cgggctgctg tcccgcatca ccgcgctggc ggcgcccggc agccgcctga
     3001 tcgccgacca cgcatacccg gaggcgctgc ggagcgaggc gttcgcagcc ggcacgcaga
     3061 ccctggcggc caacggctcc gcgttcggca gtacggtcac cgatcccgaa gcgtggctcg
     3121 ccgggcacgg ctggagcgcg gccctggcgg agccgtcgga ccttgtcggc gggaccggcc
     3181 gcgcgctgcc cgccgtcctc gaccctgccg tgccggactc ccccgtcttc tggttcgccc
     3241 tcgggcgccg tgggtgacgg cggagcgcgt gtggagcgac ggccgtgagc acgcccgcgc
     3301 gacagcgtcc tgagacgcca tcagcggcac gctgatcggc gaggaggccg ctatcgttga
     3361 cctccatgaa cagcgcctgg ttgccgatat ccgctgttac ccggcttgcc gccgcggcag
     3421 tcgtcggagt ggcgatcggc actgtcgtcg gattttcggt cgacaccccg ctcggcattc
     3481 ttgcggccat cgccgcgacc gaaacctgct tcgtggtggc cggctggacg gtgctctggc
     3541 cgatggatgc cgattccacc cgccgcaatg cgggacgcga ggacttccgc cccctcaccg
     3601 aggaactcgt cgtcatcgcg gccgctctgt gcggcctggg cggaatcgtg gtgcttctgc
     3661 tcggaaactc cgacaccagc cacgccgcgg cggcgctcgc cggcgtattc atggcatggg
     3721 cggcactgca tctgatgtat gcgactcgct acgcgtatct ctactacgtg gacgccgcgg
     3781 gcgggatcga cttcaactcc gaccaaccgc ccgcgtaccg ggacttcttc tacttcagct
     3841 acaacctcag catgacgtat caggtctccg acacggacgt ctcgaattca gcgatccgtg
     3901 cgatggcgct gcggcactgc ctgctgtcct acgccttcgg caccagcatc ctggccacgg
     3961 cgatcaacct cgtcgtcgga atcgtcagca gctgatcccg ggcagggccc ggggtctgat
     4021 ctgccccgct gctcttcatg agacgggcgg cgcgataccg ggagcgctat cccgccaggc
     4081 tgtgcccgct cgaagcagac gtcaccggca ggaaccgctg ccggtcgacg atcgcccggt
     4141 ccatctcccc tgccgcgaca agctcaccgc agtcgtccac ggcgcgcacg gcgaaggtga
     4201 gcttccggcc ggctgcggtg gccggaagtt cggccgtcac ctcgaccacc ccgcccaccg
     4261 gtgtggcacg gcggtggtcg acgcggacgg cggtccccac cgtcgtctgg ccgtctgcga
     4321 cgagcggcgt ggccgaccgt acggtctctg cttccatcca cgtgatcaac cgcggggtgg
     4381 cgagaacggg cacatcgccg ctgccgatcg ccatcgccgt atcggcttcc gtcacttcat
     4441 agcgcatcgt tcatcaccct gcatgcattc gataaaccat cttgaaaagc ccgcaacggg
     4501 agctgctcac cctggacgct atggccgagc gccggattcc gaaagccttc cattccagcg
     4561 ctggcaccgg caacaaacgg ccttgtcgca cgggacaaac gccgcacagc gacgacaggg
     4621 gcgagggttc catgcagtag cttcattcac cggcttcatt catcccggtc cgcggctccg
     4681 acgccgtccg gacccgacgg acgcaaggtg acgcaaatca ttcacagttc gcgctccgtc
     4741 tcggcggtcc ggcccggtcg cgtaagaccg tgggcttacg acgccgaagg cttacggcag
     4801 ggtgatttca cgcgtgcgtg tgtgcggcga cgcaaggtcg tagtgcgata cacaaccccg
     4861 gttgtcgtgg aggccaaacc agccgccgta atgctgtgcc ggtactctgc cgcacgatag
     4921 gttgactcag gaagccgcga tgagccgcat cccctcaacg tggctttcgt aatgtttacc
     4981 tgaatcggag cgctgccccc atgaacaacc tgcaccgcga gctcgccccc gtatccgacg
     5041 ccgcctgggc ggacttggag gccgaggccc ggcgcacgtt ccagcgcaat gtcgccgcgc
     5101 gacggctcgt ggacgtgccc gagccggcgg gggtgaagct ggcggcactc tccacgggac
     5161 acctggacac gatccagccg cctgccgacg gcgtgttcgc cgatctccgc cgcgcccaac
     5221 cgctggtgca gcttcgcgtt ccgttcagcg tctcccgcgc acaggtcgac agcgtggagc
     5281 agggagcgaa ggacgcggac tggggtccgg tgaaggaagc cgctcgacgg ctggcgctct
     5341 cggaggaccg cgcggtcttc gaaggctatg gagcggcagc catcaggggc atccgtgccg
     5401 agtcctcgaa cgcgcccctc gcgctccccg cgcaggcccg cgagtatccg gaagtggtga
     5461 gccgcgccgt cagctcactg cggctcgcgg gcgtcgaggg cccgtacgcg ctcgcgatgt
     5521 ccgcggacgc cttcaccacg gtgagcgagg cttcggacaa cggctacccg atccacgacc
     5581 acctgcgcca ggtcgtcggc ggcgaaatcg tctgggcccc ggccatcgac ggtgcgttcc
     5641 tgctgaccac gcgcggcggc gacttcgagc tggggatcgg ccaggacgtc tcggtcggtt
     5701 acctgagcca tgactccgcg gaagtggagc tgtacctcca agagtcgttc acattcctcg
     5761 tgttcacggc cgaggcgggt gtggcgctcg tcagcggtca ccagtgacgc ggcccgcccc
     5821 tctcaggctg ccgatctcca acgagccgtc cggacgcggc ggttccgcgg ttgcgtcggt
     5881 cgcggccgcc gtcgcggtcg cggtcgcggc cgcggtcgcg gccgagacgg tggggcgcgg
     5941 aggctggtcg tccaggaact ccgtggtggg gacgtagaag agtccgccgg tgaccgctgt
     6001 ggagaagtcg agaatgcggt cgtggtttcc gggcgggtcg ccgatgaaca tgttccggag
     6061 cattcgctcg atcacgtcgg ggttgacggc gtacccgatg aagtaggtgc cgaattcccg
     6121 gtcgccgacg gcaccgaagg gcatgttgtc ccgcacgatc ttgtgctcgg tgccgtccgg
     6181 atccacgatc gtgttcaacg ccacgtggga attcgacgcc ttgtccgcgt cgggcagttc
     6241 gatgtcgctg agcttccggc ggcctatcgc ctgttcctgt tcctcgatcg gcagggcgcc
     6301 ccaggcgtcc aggtcgtgca ggtacttctg cacgacgacg tagctgccac cggtgtaggc
     6361 cgggtcctcg tctccgatgt gcacgacggc gagcgcggac ggaccggacg ggctctcggt
     6421 gccgtcgacg aaccccagga ggtccctctc gtcgaagtac cggaacccgt gcacctcgtc
     6481 ggcgacgtcc acgcacccgg ccagccggtc catgatctgc cgggccagtt cgaagcacag
     6541 gtccatccgg ccggcccgca gatggaagag caggtcgccc ggggtcgaga ccgccgtgtg
     6601 caccgcgccg gccaccgtac ggaacgggtg caggcccgcg gggcgcggtg cgtcgtagag
     6661 ccggtcccac agctccgcgc ccactcccac cacgctgctc aactcgccct cgggattgcg
     6721 gaaacccact gctcgggtca gccccgcgag atcggacagc agatcccgcg cgtcctcctc
     6781 ggcacccgca cggaccgtga ccacgaggaa gatcgccgcc ttggccggcg gtgccaacac
     6841 gtgctgcggt tgcccttgat gcgccatcga tccccttaag cgtctttctc acgagagatc
     6901 gccaggctat cgcccgcggg cggccggacc ctgtctgcgc cggtcttctt gttcgcgctg
     6961 tcagtgcgcc ttggcactct cgacatcgac gcggagcgac ccgccgatga gatccccccg
     7021 ggccgcatca cccgtggctg ccgtctcgtg gtggggacgg tcgtggaaga cgcacgcggt
     7081 ggctcactgg gagcgtgacg agtgaccgtt ttgcagcagg acgttggagc tgaggctcag
     7141 ggcgtcggcg gcggtggcca gttcggcgat gccgcgcggg tcggacagtg accgtccggt
     7201 gagttcgtgt acgcggcgca gccggtagcg aacggtgttg gggtggcagt agaggacctc
     7261 ggcggcgcgc tcgctggaac cgtcatggtc gagataggcg ttgagggtgt ccagcagcac
     7321 ggcacggtcg tccggggaga gttcgagtac ggcgccgagg acctccttgg cgagacgccg
     7381 gccctcgccg ggatcgcagg ccatgagcgc ggcgagcggg ctggggctga acatccggac
     7441 ctcggcccgt cccgcgggaa gggtggcgag cgccgtccgg gccagttgca gcgcacgggg
     7501 gctgtcggcc agcgactggt agggcgggct gacgccggtg cgggcgccgg cggcctcacg
     7561 cagcacggcc agcgcggtct cgcgtacgtc gctgtgcagg gagacgatcc cgagttgcag
     7621 cgccggagtc agccgccacc cggagacgat tccgtgcgcg gccagcctgc gttcgatgcc
     7681 ggggaggctt tcctcggcga ggccgcgcgt ctccgcggcg acgaccacca cctgcgcgtc
     7741 agggggcagc ccgagcaggt tggccgcctc ccaggggccg acctccggac cgggaccgcc
     7801 ggtgagcagc gcctccacga gggcggagcg gcgctgctgc tgagcgagca gcagctcggc
     7861 ggtggcggca cggtacgcct cggtgagagc cagggcgtgc tcgtcggtga gctgccagat
     7921 catgctggcg gcggtgagca acgtgtccgc catggacggc cgttgaccgc ggcgggcgtg
     7981 ctccaccagc gcgtcccaca gggtggcgaa gctgatccgg tacgcctgga gcacctcggg
     8041 aagcggcacc ccttgatgcg cgcggcggtg gcccgtctcc cggggggcgg acaggtcgag
     8101 agagtcctgc gggtgaccga tggcgccgac catggcccgc aggttgtgcg cgatggagcg
     8161 ccgcagatcc tcggaggaca cgggctcgcc gtcgcggtag atctcgatgc ggtcgaggac
     8221 cgtggcgtgt gcgtcgtcga tcaaccgggg aagccgatcg ctggcccacg ccgccaggtc
     8281 ggccagtccg ttgcgcgtca ttggctcccc ttccggctgt gcgctgcgta ccgaaccggc
     8341 gcggccggac gccggcgaaa tcgtaagctg gcgcgatcac cttgagaaag gcgtgagggc
     8401 ggcccggcaa gccgcctgaa gggcgtgtgc gctgcaccgc ctcgatcccc gcctcgatcc
     8461 ccgttccggc accgcgcgac gacgagtcga ccgtgcgacc tggcggaggg tgcctcggct
     8521 gaacgcggtg tattcaccgg cccgatggga cgggacgcgc gacaccgaag ccgggccgga
     8581 ccggacgcac ggaccggctc ggtccgtggc gtggacgttc gtcgtcctcg tcctggcgta
     8641 cggcctgttc aacgccgtca aggcggcact acaactgttc accggctgac cggtgttcac
     8701 acgctgaacg cagacccggg gcctcggcgg ccgtctcgtc cgtacgtacg gaacgggcgg
     8761 cccgccgggg ccccgcgccg tacggtcact cgtcccgcgt cgcgcttctc tctgcccggg
     8821 cccgctcgga cggtcccggc tcgggtgccg aaggcggctc ctgggcggct cccatcacgg
     8881 cgggcagatg gcggcggctg tagaacgccg tgatcccgag gaagagcacg ccgaccgcgg
     8941 ccagtcccac cagaagtgcc ggataggggg cggctcccgc gctcatcgcg aggaggagcg
     9001 gcgcgaggaa accgctgtgg gtggcgccct ggtagaccga ggaggcggtg ggcaacgcgg
     9061 gcccgtgcgc gagccgttcg atctccttca gcccggacgc gagggtcagc ccgtagccgg
     9121 cgccgaggac cacggcggcg ggcagcacca gcagcgggga gtccagatac acggcgacgg
     9181 cgcccgccag gagcccgacc acgacggtgg ccatggcgac cagcgtggag cgcgcgctgc
     9241 ccgcctggtc cagccatgtg gcgagcggct gcacggcgac gcccgtcgcg atcgtcaccc
     9301 ccacgaccag gccgctgaac atcggtgcgt ggccgtgtac ttggtcgatc accagcggcg
     9361 gcagcacgac gtacgccacg gtggccgcgg cgaaggccgc cgggctggcg ggcagcacca
     9421 cgagcacgaa ccgtgggtga gtgacgatgg tccagcgcat gcgcggggga cgcggtggcg
     9481 ccgtaccgtc ctcgcgggac ggagtcgtgt ccggcgagcc gcgcgtcgcg aagaacacca
     9541 gcagcacgag gacgccgtgc aacaggcagg gcagcaccat cggttggggc agccattcgg
     9601 ccacgactcc ggcggccagc gcccccgagg cgaatccggc gccggtggcg tacagggcac
     9661 ggcggttccc ggcgtcctga ccccgggcct cggagatctc ctccagccag gtcgcacccg
     9721 cggacaggac gatcccggcg gcgagcccgg tggccagacg gctcggatac accgcgtcct
     9781 cggtgaccac cgctgccgcc agcgccgtgc tcgccgcgga tgacatcgcc agcgcaccgc
     9841 gcacggcgcg ccgtctgccg taccggtcgg cgatccggcc gcccaggagc agccccggga
     9901 cgaggccgac gagatacagg gtgaacatcg cggccaccgc gagggcggcc cagccctccc
     9961 gcacccggta gacgacggcg agcggagcga actggctggc cccccaaccc gcgacgtaca
    10021 gcgcggacgc caccggaagc caaccgcgtg tggcgttcga aacgggcatg cctgagcggc
    10081 ccttcccttc tgctcggtgt ggccgggccg ctcggctcgt ctcagctcgc cggggcggcc
    10141 accggttcca gacgcacgac gacgcccttg gacgtcgggg tgttgctgat ctcggcgacg
    10201 ctgtcgaggg gcaccaggac gttggtctcc gggtagtacg aggcggcgga gcccggagcc
    10261 gtcgggtagg acaccacccg gaagccgtcc gcgcggcgct ccaccccgtc gtcccacacg
    10321 ctgacgatgt cgacctgctg gccgtcggac aggccgagtt cgctcacgtc gtccgggttg
    10381 accatcacga tgcggcgggc gttgtggatg ccgcggtagc ggtcgttcat cgcatacggg
    10441 atcgtgttcc actggtcgtg cgagcgaagg gactggagca ccagatggcc gcggggcgcg
    10501 ctgagcatcg tgaacgcgtt gcaggtgaag acggccttgc cgctcggggt ggggaagtcg
    10561 tgccggttga cggggttggg cagccggaat ccgccgggct cggcgacgcg ctcgttgaag
    10621 tcctcgaagc ccggtacgac gcgggagatc cggtcccgta cggtgccgta gtccttctcg
    10681 aactcctccc aggggatggc cacttcggag ccgagcgtgc gccgggccag tcggcacagg
    10741 atcgcgacct cgctgagcag atgcggagac gcgggctcca gccgtccgcg tgaggcgtgc
    10801 acctcgc
//
