LOCUS       NZ_JAASAG010000005     11416 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. HNM0575 scfid5, whole genome shotgun sequence.
ACCESSION   NZ_JAASAG010000005
VERSION     NZ_JAASAG010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. HNM0575
  ORGANISM  Streptomyces sp. HNM0575
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 466609)
  AUTHORS   Xiao,K.
  TITLE     New actinomycetes from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 466609)
  AUTHORS   Xiao,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-MAR-2020) College of Tropical Crops Hainan University,
            Hainan University, Renmin Avenue, HaiKou, HaiNan 570100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2018
            Assembly Method                   :: SOAPdenovo v. 1.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012726265.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 05:29:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,992
            CDSs (total)                      :: 5,923
            Genes (coding)                    :: 5,797
            CDSs (with protein)               :: 5,797
            Genes (RNA)                       :: 69
            rRNAs                             :: 5, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 126
            CDSs (without protein)            :: 126
            Pseudo Genes (ambiguous residues) :: 0 of 126
            Pseudo Genes (frameshifted)       :: 15 of 126
            Pseudo Genes (incomplete)         :: 115 of 126
            Pseudo Genes (internal stop)      :: 5 of 126
            Pseudo Genes (multiple problems)  :: 8 of 126
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 450678
            Orig. end                         :: 462094
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAASAG010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11416
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11416
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11416
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6416](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6416)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            480..2030
                     /gene="hemG"
                     /locus_tag="HCC61_RS15495"
                     /old_locus_tag="HCC61_15495"
     CDS             480..2030
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962203.1"
                     /locus_tag="HCC61_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_15495"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_169136019.1"
                     /sec_met_domain="DAO (E-value: 2.4e-09, bitscore: 31.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHVIVIGGGISGLAAALRLSSGGASVTVLEASARLGGKLLPGAVA
                     GSAAVDLGAESMLARRDEGVDLARAAGLGESLEAPAGAGAAIWSRGGMCPMPKGHVMGV
                     PGDPEALRGLVSDEGIARAERDAGLPRTEIGEDAAIGEYVAERLGREVVDRLVEPLLGG
                     VYAGDAYRISMRAAVPQLYEAARGGSSLLAGVRALQQRAPVQPPGAPVFMGIRGGVGRL
                     PGAVADACRAEGARIRTGVPVRSVHASAVADGAVPGSGAGPASVAGTDAGSGSGAGSGR
                     GAGSVSGRDAGAGRRWSVVTESGESLHADAVVVAVPAPQAARLLADEVPVAAAELRTVE
                     YASMALVTMAFRRSELERASEPPPAGSGFLVPPVDGRTIKAATFSGNKWGWVAAQDPEL
                     FVLRTSVGRYGEEAVLEREDSEIAELSLHDLAAATGLRARPVDRLVSRWHGGLPQYPVG
                     HTARVARIRAAVARAPGLAVCGAAYEGVGIPACVASGRRAAGEIQETLARAPAGGARE"
     gene            2035..2766
                     /gene="hemQ"
                     /locus_tag="HCC61_RS15500"
                     /old_locus_tag="HCC61_15500"
     CDS             2035..2766
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714421.1"
                     /locus_tag="HCC61_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_15500"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_169136020.1"
                     /transl_table=11
                     /translation="MTAAPEPGKPEKAPNAGKKAKDLNEVVRYTLWSVFRLRGELPDDR
                     AGHAAEVDELFAQLAAKDVVVRGTYDVSGLRADADLMIWWHAESSDALQDAYNRFRRTR
                     LGRAVEPVWSNMALHRPAEFNKSHLPAFVAGEEPRAYVSVYPFVRSYDWYLLPDEDRRR
                     MLADHGRMARGFPDVRANTVPAFSLGDYEWILAFEADELHRIVDLMRHLRGSEARMHVR
                     EEVPFFTGRRKPVAELVAGLV"
     gene            complement(2847..4664)
                     /locus_tag="HCC61_RS15505"
                     /old_locus_tag="HCC61_15505"
     CDS             complement(2847..4664)
                     /NRPS_PKS="Domain: Abhydrolase_1 (179-360). E-value:
                     5.8e-14. Score: 44.2. Matches aSDomain:
                     nrpspksdomains_HCC61_RS15505_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950060.1"
                     /locus_tag="HCC61_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_15505"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_346777213.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-17, bitscore: 58.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTALYGTLGALALTVMTVVPAGPAGPAGPAGPAGPAVGGPSTA
                     WGRGTGTAAASATTASAATSSAATITTAHDGLPLPLRDARAAVGTAIAAEAAAEAGIDW
                     SRCPASEELPAYAECGKVDVPVDYADPDARKIALTVSRKRATGPASVRQGPLLHNPGGP
                     GADGMGFPLHPTLRGGVWKKLNRAYDFVGYAPRGVGRSAPLRCRGPEHTRRTAARGARA
                     GSAEAEAGAEATAVPRSPRTPSAAFKRELRAQAAAFARACARRYGDTLAHFTTADNARD
                     LDVLRAALHQEKLSFFGTSYGSYLGAVYAALFPGHVRRLVLDGVVDPRPHRIWYGDALA
                     QSSAFQRRWRDFTSWTARRHSVYGLGRTPRSVQRHFDTARAALDHDPAGAADSPGGQGA
                     GLQLLRAALRAGHDQGSWPRLALALAEFSRGDPDALTRIAAPDPRTEAERDNSDSVYSA
                     VQCSEGHWPRRWPRWDRDNTAIGGAAPYQTWETVRADLPCAYWRGVRSRPVDVRTAPGE
                     LPPVLLLASTRDAATPYEGAVETWKRLSGSSLVTERGAVTHGVAGGNRCADAHLAVYLL
                     DGRTPGRAAECAARPAPRAAARPGSEDVP"
     aSDomain        complement(3585..4127)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS15505_Abhydrolase_1.1"
                     /evalue="5.80E-14"
                     /label="HCC61_RS15505_Abhydrolase_1.1"
                     /locus_tag="HCC61_RS15505"
                     /protein_end="360"
                     /protein_start="179"
                     /score="44.2"
                     /tool="antismash"
                     /translation="VWKKLNRAYDFVGYAPRGVGRSAPLRCRGPEHTRRTAARGARAGS
                     AEAEAGAEATAVPRSPRTPSAAFKRELRAQAAAFARACARRYGDTLAHFTTADNARDLD
                     VLRAALHQEKLSFFGTSYGSYLGAVYAALFPGHVRRLVLDGVVDPRPHRIWYGDALAQS
                     SAFQRRWRDFTSWTARRH"
     gene            complement(5001..6416)
                     /locus_tag="HCC61_RS15510"
                     /old_locus_tag="HCC61_15510"
     CDS             complement(5001..6416)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034053.1"
                     /locus_tag="HCC61_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_15510"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_206322505.1"
                     /sec_met_domain="DUF692 (E-value: 1.7e-93, bitscore: 307.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTTGTRVRLGTGIGWRPEIADGIAALPGIDWVEVVAENVCPDPD
                     HLPDGLRRLRERGTTVVPHGVSLGIGGAELPDPARLSALAERAEALDAPLVTEHIAFVR
                     AGGPPTGVPRMEAGHLLPVPRTRDALDVLCENVRVAQEALPVPLALENIAALVAWPGEE
                     LSEGAFLAELVERTGVRLLIDVANLHTNHVNRGEDPCAALDELPLDALAYVHVAGGFER
                     DGVWHDSHGHPVTRPVLDVLAQLRARTEPPGVLLERDENFPPVSELAEELESIRSVLQD
                     TAPARELREPREPGTLPAGGAGPGEERRGRATASAATETRQRPAQAQDRLAQARERLAR
                     AEAGLLAALVADAPAPEGFDRERLDVQRRALAAKRRDVVAKVAPELPSILGEKTFRSAF
                     AAYARTVPLTGGYRRDALDFAAYTLDEGAAGGRRTHGRLRTWWLERSAPEPPPGGRVRR
                     MLHLTRERVRMHR"
     gene            complement(6638..7456)
                     /locus_tag="HCC61_RS15515"
                     /old_locus_tag="HCC61_15515"
     CDS             complement(6638..7456)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142808.1"
                     /locus_tag="HCC61_RS15515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_15515"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_169136021.1"
                     /transl_table=11
                     /translation="MSDAGQDVRKGTGREAGRASDRETGQEPGKDAGTHPERAPRGQAH
                     EPEQAREFALPLVVRLERGTPPHRTDALETAARAVLTLLADERSADGGEWSERVRSWED
                     TAIRKVVRRARGAEWRRAEALPGITVTGRTAEVRVFPPVPVGDWPRDLARLQVSGTELT
                     DPEPPPAPAPAMPVMWLAPDLEMSAGKAMAQAAHGAQLAWWRLPDAARKRWREADFALA
                     VRTASGVRQWSRLLECGLPVVRDAGYTEVAAGSVTVVADFAGLLDVDARG"
     gene            7495..8346
                     /locus_tag="HCC61_RS30215"
     CDS             7495..8346
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997024.1"
                     /locus_tag="HCC61_RS30215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_206322506.1"
                     /transl_table=11
                     /translation="MRLDGVGRRYGLRGSWVLRGVGLSLPGRRLVRVQGANGSGKSTLL
                     RLLAGIDAPSAGRITGRPQSAYVPERFPAAMPLTALGYLTRMGTVHGLRRDAAADEARE
                     WLERFGAASYARTPLAELSKGSSQKVAVAQALMARPALLVLDEAWTGLDENARTVLDRS
                     VAERVAEGGTVVFVDHDPARLAGAADVTYRVEHGGVQEVAGFVPPGHAGVPADGPRVRI
                     EAEGPPGAALPSGLPGAPRTERTPDGATVLTASAPYSDALLRSLLAGHWHIRSVAVEEA
                     SP"
     gene            8343..9011
                     /locus_tag="HCC61_RS30220"
     CDS             8343..9011
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055559.1"
                     /locus_tag="HCC61_RS30220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter"
                     /protein_id="WP_346777214.1"
                     /transl_table=11
                     /translation="MKALLAYQTELLVRSQRWLPPLLLYAAFLGLGVQWGRPLLDALGY
                     SAAALLPVAVWLVRVCVSGEPPAARHCTAAAAGPGRVHLASVLTALLAACVLGAAATLY
                     AVAVSEPHSSEGHVEVPLPQAAGAGLLAVAACALFGTAVGALCSRPVLRSTGVAVPSAV
                     VAALLVLVAGGSPANAAVSGLVTGSHTGTVTVPWMPAGLSVAVAAAAVGFACRQASRRS
                     "
     gene            complement(9202..10587)
                     /locus_tag="HCC61_RS15525"
                     /old_locus_tag="HCC61_15525"
     CDS             complement(9202..10587)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358858.1"
                     /locus_tag="HCC61_RS15525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_15525"
                     /product="alkaline phosphatase PhoX"
                     /protein_id="WP_169136022.1"
                     /transl_table=11
                     /translation="MTTRRQVLARSGALGAGIAFSGALSELFTGTAAAQGTGGRSGYGP
                     LIEDPDGVLDLPEGFSYKILSREGDDLRSGEGKVPSHCDGMAAFAGPHGHDGRHGSTWL
                     VRNHENRMDAENGVPTVDGLTYDPAALGGCTVLELDGDNEVRQERVGIAGTSTNCAGGH
                     SLWDTWLTCEETEFKAGEEGYTKDHGFIFEVGFRKDRPTSTEPLKAMGRFQHEAVAFDP
                     RNGVVYETEDAFEKPFGLFYRFLPEKPLGGYGSLHAGGRLQAMRVPGVPDLSVVQEPGT
                     GFEGIEWVDVPDPLAKETAIRFQDFGKGGITHAQKLEGCYWGGKSVYFVSSYAKSEEGS
                     KADHYGQIWRYDPKHKKLTLVIVFGPDTDLNLPGEEPDNICLAPSGGLMVCEDGEGAQH
                     VFGLTKEGAVYPMARGRQDVGTPEEPAWGEFAGVTFSPDNRTMYVNCYDPGTTFAVTGP
                     WKH"
ORIGIN
        1 tctccggggg cgagttcgcg ggcgagcacc cggcggcggt ccgtgtcgag gcgggtgacc
       61 tcggtgtgca tgcgcaggtc gatgccgcgc tcgcggtgct ttccgggcgt acgggcgatc
      121 aaatcgtcgc ggtcggagac gtcgccgccg atccagtacg ggatgccgca cgcggagtag
      181 gaggagaagg cgccccgctc gaaggcgacg acctccagct cgtccgggcc cagcaggcgg
      241 cgtgcctggg aggcggcggt catgccggcc gcgtcacccc cgacgacgac catgcggcgt
      301 gcggcagcca tgatccgtac tccctccgtt gtggccgtgg ccgtggccgt gaccgtggcc
      361 gggccgggcg tggatggggc gggtcggggg cctgcgccgg gacgccgccc gggagtctcc
      421 cgcttccgtc ccgttcccct ggttacggcg ggcggtaccc gcgctgggac gatggacaca
      481 tgcatgtgat cgtgatcggc ggcggcatct cggggctcgc cgcggccctg cggctctcct
      541 cgggcggcgc ctcggtgacc gtactggaag cgtccgctcg gctgggcgga aagctgctgc
      601 cgggcgccgt cgccgggagc gcggccgtcg atctgggcgc ggagtcgatg ctcgcgcgcc
      661 gcgacgaggg cgtggatctc gcgcgtgcgg cggggctcgg tgagtcgctc gaagcccctg
      721 ccggcgccgg tgccgcgatc tggtcacggg gcgggatgtg ccccatgccc aagggccatg
      781 tgatgggcgt accgggagat ccggaggcgc tgcgcgggct ggtctccgac gaggggatcg
      841 cacgcgcgga acgggacgcg gggctgccgc gcacggagat cggggaggac gccgcgatcg
      901 gcgagtacgt ggcggagcgc ctcggccgcg aggtggtgga ccggctggtg gagccgctgc
      961 tggggggcgt gtacgcgggc gacgcgtacc ggatctcgat gcgtgccgcc gtgccgcagc
     1021 tctacgaggc ggcgcgcggc gggagttcgc tgctggcggg ggtgcgcgcc ttgcagcagc
     1081 gggcgcccgt gcagcccccg ggggcgcccg tcttcatggg gatccggggc ggcgtcgggc
     1141 ggctgccggg cgcggtggcg gacgcgtgcc gtgcggaggg ggcgcggatc aggacggggg
     1201 ttcccgtacg gagcgtgcac gcgtcggccg tcgcggacgg ggcggttccg ggttccgggg
     1261 ccggaccggc ttccgtggcc ggtactgacg ccggttcagg ttccggtgcc ggttcaggtc
     1321 gtggtgccgg ttccgtttcc ggtcgtgatg ccggtgccgg ccgacgttgg tccgtcgtca
     1381 ccgagagcgg cgagagcctg cacgccgacg cggtcgtcgt cgccgtgccc gcaccgcagg
     1441 ccgcgcggct gctggccgac gaggtgcccg tggcggcggc cgagctgcgc accgtggagt
     1501 acgcgtcgat ggcgctggtc accatggcgt tccggcgctc ggagctggaa cgggcttccg
     1561 aaccgccgcc cgccggcagc ggattcctgg tgccgcccgt cgacggacgc accatcaagg
     1621 ccgccacctt ctccggcaac aagtggggat gggtggccgc gcaggacccg gagctgttcg
     1681 tgctgcgcac ctccgtcggc cggtacgggg aggaggccgt gctggagcgt gaggactccg
     1741 agatcgccga actgtcgctg cacgatctgg cggccgcgac cgggttgcgg gcccgccccg
     1801 tcgaccggct ggtcagccgc tggcacggcg gcctcccgca gtacccggtc ggccacaccg
     1861 cccgcgtcgc ccgcatccgt gccgccgtcg cccgggcgcc cgggctggcg gtgtgcggag
     1921 cggcgtacga gggcgtcggc atccctgcgt gcgtcgcgag cggacggcgc gcggccggtg
     1981 agatccagga gaccctggcg cgggcacccg cgggcggcgc gcgagaatag ccgcatgact
     2041 gctgcaccgg agccgggcaa gccggagaag gcccccaacg cggggaagaa ggccaaggac
     2101 ctcaacgagg tcgtccgata caccctgtgg tcggtcttcc ggctgcgcgg cgaactgccc
     2161 gacgaccgcg ccggacacgc ggccgaggtc gacgagctgt tcgcgcagct cgccgccaag
     2221 gacgtggtgg tgcgcggcac ttacgacgtc tcggggctcc gtgccgacgc cgacctcatg
     2281 atctggtggc acgccgagtc gtccgacgcc cttcaggacg cctacaaccg cttccgccgc
     2341 acccggctgg gccgcgcagt ggagccggtc tggtcgaaca tggcgctgca ccgcccggcg
     2401 gagttcaaca agtcgcacct gccggccttc gtggcgggcg aggagccgcg ggcgtacgtg
     2461 agcgtgtatc cgttcgtgcg ctcctacgac tggtatctgc tgccggacga ggaccgccgc
     2521 cgcatgctcg cggaccacgg caggatggcc cgcggcttcc cggacgtacg ggcgaacacg
     2581 gtgcccgcct tctccctcgg cgactacgag tggatcctcg cgttcgaggc cgacgaactg
     2641 caccgcatcg tcgacctgat gcggcacctg cggggctccg aggcgcggat gcacgtgagg
     2701 gaagaggtgc cgttcttcac cgggcggcgc aagccggtcg cggagctggt ggcggggctc
     2761 gtctgagggg cagggctcgt ctgaggggac gggcggtccg gggcacggtt ggtccgggtc
     2821 acggccggtt cgggggctcg gctcgtctag ggcacgtcct cggagccggg ccgggccgcg
     2881 gcccgtggtg cgggtctggc cgcgcattcc gcggcgcggc cgggcgtgcg gccgtccagc
     2941 aggtacacgg cgagatgagc gtcggcacac cggtttccgc ccgcgacgcc gtgcgtgacg
     3001 gcgccccgct cggtgacgag ggacgagccg gacagccgct tccacgtctc gacggcgccc
     3061 tcgtacggtg tggcggcgtc ccgggtcgac gcgagcagca gcaccggcgg cagttcgccc
     3121 ggcgcggtgc gtacgtcgac gggcctggag cgcacgcccc gccagtacgc gcagggcagg
     3181 tcggcccgca cggtctccca cgtctggtac ggcgcggccc cgccgatcgc ggtgttgtca
     3241 cggtcccagc gcggccaccg ccgcggccag tggccctcgg agcactgcac ggcgctgtag
     3301 acggagtcgc tgttgtcgcg ctcggcctcc gtgcgcgggt cgggggccgc gatccgggtc
     3361 agcgcatcag ggtctccccg gctgaactcg gcgagtgcca gggcgagtcg gggccagctc
     3421 ccctggtcgt ggccggctcg cagagcggcg cgcaggagtt gcagcccggc gccttggccc
     3481 cccggtgaat cggcggcgcc ggcggggtcg tggtcgaggg cggctcgtgc cgtgtcgaag
     3541 tggcgctgta ccgatcgcgg ggtgcggccg agaccgtaga cggagtgacg gcgcgcggtc
     3601 caggacgtga agtcccgcca gcggcgctgg aacgcgctgc tctgggcgag cgcgtcgccg
     3661 taccagatcc ggtgcggacg cgggtcgacg acgccgtcga gtacgaggcg gcgcacgtgg
     3721 ccggggaaga gggcggcgta cacggcgccg aggtaactgc cgtacgacgt cccgaagaag
     3781 ctcagcttct cctggtgcag ggcggctcgc agcacgtcga ggtcgcgggc gttgtcggcg
     3841 gtggtgaagt gggcgagcgt gtcgccgtac cggcgggcgc aggccctcgc gaacgcggcc
     3901 gcctgagcgc gaagttcgcg cttgaacgcg gcggagggcg tacggggtga gcgtggcacg
     3961 gccgtcgctt ccgcacccgc ttccgcttcc gcgctcccag cccgtgcgcc gcgggccgct
     4021 gttcggcgcg tgtgctccgg gccccggcac cggagggggg ccgagcgtcc gacgccgcgg
     4081 ggcgcgtaac cgacgaagtc ataggcgcgg ttgagcttct tccacactcc gccccgcagg
     4141 gtggggtgga gcgggaagcc catgccgtcg gccccggggc cgcccgggtt gtggaggagc
     4201 gggccctgcc ggacggaggc ggggcccgtc gcgcgcttac ggctcacggt gagggcgatc
     4261 ttccgggcgt ccgggtccgc gtagtcgacc ggcacgtcga ccttgccgca ctcggcgtac
     4321 gcgggaagct cctcggaagc ggggcagcgc gaccagtcga tgcccgcctc ggccgccgct
     4381 tcggctgcga tcgccgtgcc gacggccgcg cgggcgtcgc ggaggggcag cggcagaccg
     4441 tcgtgtgcgg tcgtgatggt ggctgctgaa ctggtggctg cggaagcggt ggtggcgctg
     4501 gccgcggctg tgcccgtgcc cctgccccag gccgtgctgg ggccaccgac tgccggaccg
     4561 gccggaccgg caggaccggc cgggcctgcc gggcctgccg ggacgacggt catgacggtg
     4621 agggcgaggg caccgagcgt gccgtacaag gcggttgagc gcaccgggtg cctcgttcct
     4681 gtcgtggtgc gaacgggcgc ccggagggtg ggaaggggtc ggccgacggc cgtaccaggg
     4741 gcctcggagc agtgccgtgc gtgagcgtcc gtgcgcagcg tgtgatcaca cctgcaacgc
     4801 gcatgctccg tacgggagtt ggcgaagtaa agcaccccgg gcggatgtcg ggggtgatgc
     4861 gcacgaagcg gggagtgtgg gcgctgccgt gcgaaatgcg gcggggcggc ccggcggtgg
     4921 gctcccgtcc cttagggcgg taggcccttt accgcggtgg gccctcatgg cagtggaagc
     4981 cggtggcggc gagcccgtgg tcagcggtgc atgcggacgc gctcccgcgt caggtgcagc
     5041 atgcgccgca cccggccgcc gggcggcggc tcgggcgcgg agcgctcaag ccaccaggtc
     5101 cgcagccttc cgtgcgtccg ccgtccgccc gcggcgccct cgtccagcgt gtacgcggcg
     5161 aagtccagcg cgtcgcgccg gtagccgccc gtcaggggaa cggtgcgcgc gtacgcggcg
     5221 aaggcgctgc ggaaggtctt ctcgcccagg atcgacggga gttcgggtgc caccttggcc
     5281 accacgtccc gccgcttggc ggccagcgca cggcgctgca catcgagccg ttcgcggtcg
     5341 aagccctccg gcgcgggcgc gtccgcgacg agcgcggcga gcagcccggc ctccgcccgc
     5401 gcgaggcgtt cccgtgcctg cgcgagccgg tcctgcgcct gcgccgggcg ttgccgggtc
     5461 tccgttgcgg cgctggcggt ggcgcgcccg cggcgctcct ctccgggacc agcgccccct
     5521 gcgggcaagg tgcccggctc cctcggctcc ctcaactccc ttgccggagc ggtgtcctgg
     5581 agcacggagc ggatgctctc cagctcctcg gcgagttcgc tcacgggtgg gaagttctcg
     5641 tcccgttcca gcagcacgcc cggcggctcc gtacgggcgc gcagctgcgc gagcacatcc
     5701 agcacgggcc gggtgacggg gtgcccgtgg ctgtcgtgcc agacgccgtc ccgttcgaag
     5761 ccgcccgcca cgtgcacgta cgccagcgcg tccaggggca gttcgtccag cgcggcgcac
     5821 gggtcctcgc cgcggttgac gtggttggtg tgcagattgg cgacgtcgat gagcaggcgc
     5881 acgcccgtac gctccacgag ttcggcgagg aaggcgccct cgctcagctc ttcgccgggc
     5941 catgccacga gggccgcgat gttctccaga gccagcggca ccggcagtgc ttcctgtgcg
     6001 acgcgtacgt tctcgcacag cacgtccagg gcgtcgcggg tgcggggcac cggcagcaga
     6061 tggcccgcct ccatccgcgg cacgccggtc gggggcccgc ccgcacgcac gaaggcgatg
     6121 tgctccgtga cgagcggcgc gtccagcgcc tcggcgcgct cggccagggc cgacagccgt
     6181 gcggggtccg ggagttcggc gccgccgatt ccgagggaga cgccgtgcgg gacgacggtc
     6241 gtgccgcgct cgcgcaggcg ccgcagcccg tcgggcagat ggtccggatc cgggcagacg
     6301 ttctcggcga ccacctcgac ccagtcgatg ccgggcagcg ccgctatgcc gtccgcgatc
     6361 tcgggccgcc agccgatgcc ggtgcccagc cgcaccctgg tgccggtcgt ccccatgtgc
     6421 gcccccctcc ttctccgtgc tgtgtctccc cggcggtcgg cagaccgcgg tgtggtgccg
     6481 tgcccgccgg tgccggtgcc tggccggtgc cggggcggct gcgcatacgt gctgtatacg
     6541 agcggtacgc tcgccgtctc cgtgcttctg ccacgcggcg ggcggccgaa tccgccaagc
     6601 cgcgtattca gagccgtatt tgaggttcgc gtcccgttca gccccgggcg tccacgtcca
     6661 gcagccccgc gaagtcggcc accaccgtca ccgagccggc ggcgacctcg gtgtaccccg
     6721 cgtcccgtac gaccggaagc ccgcactcca gcaggcgcga ccactgccgg acaccgctcg
     6781 ccgtgcgcac ggcgagggcg aagtccgcct cgcgccaccg cttccgcgcc gcgtccggca
     6841 gccgccacca cgccagctgc gcgccgtgcg ccgcctgcgc catcgccttg cccgccgaca
     6901 tctccagatc cggcgccagc cacatcaccg gcatcgcggg tgcgggggcc gggggcggct
     6961 ccggatcggt cagttcggtg ccggagacct gcaaacgggc caggtccctc ggccagtcgc
     7021 cgacgggcac gggcgggaag acccgtacct cggcggtacg gcccgtcacc gtgatccccg
     7081 gcagcgcctc cgcccggcgc cactccgcgc cgcgcgcacg ccgcaccacc ttgcggatgg
     7141 cggtgtcctc ccagctgcgc acccgttccg accactcgcc gccgtccgcg gagcgttcgt
     7201 cggcgaggag ggtgaggacc gcgcgggctg ccgtctccag ggcgtcggta cggtgcgggg
     7261 gcgtgccgcg ctccagccgt acgaccagcg gaagcgcgaa ctcccgcgcc tgctccggtt
     7321 cgtgtgcctg tccccgcggg gcccgctccg ggtgtgttcc ggcgtccttc cccggctcct
     7381 ggcccgtctc ccggtccgag gcgcgccccg cctcgcggcc cgtgccctta cgtacgtcct
     7441 gtcctgcgtc gctcaccagg tcagtctgcc agggctccgc tactgtcaac tcgtatgaga
     7501 ctggacggag tcggccgccg ctacggtctg cgcgggagct gggtcctgcg cggcgtcggc
     7561 ctgtcgctac ccgggcggag actggtgcgc gtgcagggcg ccaacggcag cggaaagtcc
     7621 acgctgctgc ggctgctcgc cggcatcgac gcgcccagcg cgggccggat caccggccgc
     7681 ccgcagagcg cttatgtgcc cgaacgcttc ccggcggcca tgccgttgac cgctctcggc
     7741 tatctcaccc gcatgggcac ggtgcacggg ctgcgacggg acgcggccgc ggacgaggcc
     7801 cgcgaatggc tcgagcgctt cggggcggcg tcctacgcgc gcacgcctct cgccgaactc
     7861 tccaagggca gcagccagaa ggtcgccgtc gcgcaggcgc tgatggcccg ccccgccctg
     7921 ctcgtcctgg acgaggcctg gacggggctg gacgagaacg cccgtaccgt gctggaccgt
     7981 tcggtcgccg aacgcgtggc ggagggcggc accgtcgtct tcgtcgacca cgatcccgcg
     8041 cggctggccg gtgccgccga tgtgacgtac cgggtcgagc acggcggtgt gcaagaggtc
     8101 gccggatttg tgccgccggg ccacgccggc gtccccgcgg acggaccgcg ggtgcgcatc
     8161 gaggccgagg gcccgcccgg cgccgcgctg ccgtccgggc tgccgggcgc cccgcgcacg
     8221 gagcggaccc ccgacggggc cacggtgctg acggcttcgg ccccgtactc cgacgcgctg
     8281 ctgcggagcc tgctcgccgg gcactggcac atccgttccg tcgcagtcga ggaggcctcc
     8341 ccgtgaaggc gctgctcgcc taccagaccg aactgctcgt gcggtcccag cggtggctgc
     8401 cgccgctgct gctgtacgcg gcgttcctgg gcctgggcgt ccagtggggc aggccgctgc
     8461 tggacgcgct cggctactcg gccgccgcgc tgctgcccgt ggccgtgtgg ctcgtacggg
     8521 tctgcgtgag cggcgaaccg cccgcggccc ggcactgcac cgcggcggcc gcgggaccgg
     8581 ggcgcgtaca tctggcgagc gtgctgacgg cgctgctcgc cgcgtgcgtg ctcggcgccg
     8641 cggcgacgct ctacgcggtt gcggtcagcg aaccccacag ctccgagggg catgtcgagg
     8701 tgccgctgcc gcaggcggcg ggcgccgggc tgctcgcggt cgcagcctgc gcgctcttcg
     8761 gcacggccgt cggtgcgctg tgcagccgtc cggtgctgcg cagcacgggc gtggccgtgc
     8821 cgtcggcggt ggttgccgcg ctgctggtgc tggtggcggg cggttcgccc gcgaacgccg
     8881 cggtctccgg actggtgacg ggctcccata cgggaacggt gaccgtgccc tggatgccgg
     8941 ccggtctctc cgtcgccgtc gcggcggcgg ccgtgggctt cgcctgccgg caggcgtcca
     9001 ggcggagttg aggccgtgcg ggagccgcgc cgccgccccg ggaaccccgt acggcccggt
     9061 gccccccccg agaggggccc gggccgcacg gccggagaag ggggcgaagg ggcggcgccg
     9121 ggtctcaacc cggtcgcgcc gcccccttgt tcagtggcac cccttgttca gtggcacccc
     9181 ttgttcagtg ccgcccccgg ttcagtgctt ccagggaccg gtcaccgcga acgtggtgcc
     9241 cgggtcatag cagttgacgt acatcgtccg gttgtccgga gagaaggtca cgcccgcgaa
     9301 ctcgccccac gcgggctcct ccggcgtacc gacgtcctgc ctcccgcgcg ccatcgggta
     9361 gacggcgccc tccttggtga ggccgaagac gtgctgtgcg ccctcgccgt cctcgcacac
     9421 catgagcccg ccgctcgggg ccaggcagat gttgtccggc tcctcgcccg gcaggttcag
     9481 atccgtgtcg ggcccgaaga cgatgacgag cgtgagcttc ttgtgcttcg ggtcgtagcg
     9541 ccagatctgg ccgtagtggt cggccttcga gccctcctcg ctcttggcgt aactggagac
     9601 gaagtagacc gacttgccgc cccagtagca gccctccagc ttctgggcgt gcgtgatgcc
     9661 gcccttgccg aagtcctgga agcggatcgc ggtctccttg gctagcgggt cgggcacgtc
     9721 gacccattcg atgccttcga agcccgtgcc cggctcctgt acgacggaca ggtcgggcac
     9781 gcccggcacc cgcatcgcct ggagccttcc gccggcgtgc agggagccgt aaccgccgag
     9841 cggcttctcg ggcaggaagc ggtagaagag cccgaacggc ttctcgaagg cgtcctccgt
     9901 ctcgtacacc acgccgttgc gcgggtcgaa ggcgacggcc tcgtgctgga agcggcccat
     9961 cgccttcagc ggctcggtgg aggtcggccg gtccttgcgg aagccgacct cgaagatgaa
    10021 gccgtggtcc ttggtgtagc cctcctcacc ggccttgaac tcggtctcct cgcaggtcag
    10081 ccaggtgtcc caaagactgt gtccgcctgc gcagttggtg gaggtgccgg cgatgccgac
    10141 gcgctcctgg cggacctcgt tgtcaccgtc gagttcgagg acggtgcagc cgccgagcgc
    10201 ggcggggtcg taggtgaggc cgtcgacggt ggggacgccg ttctccgcgt ccatccggtt
    10261 ctcgtggttg cgtacgagcc acgtcgagcc gtggcggccg tcgtggccgt gcggtccggc
    10321 gaaggcggcc ataccgtcgc agtggctggg caccttgccc tcaccggagc gcaggtcgtc
    10381 gccctcgcgg gagaggatct tgtagctgaa gccctcgggc agatcgagga cgccgtcggg
    10441 gtcctcgatc agcggcccgt agccggagcg gccgccggtt ccctgggcgg ccgccgtacc
    10501 cgtgaacaat tccgaaaggg cacccgagaa ggcgatgccc gctcccaacg cgcccgatct
    10561 tgccagcact tgacgtcgtg tcgtcatccg gaactccctg tcggccgggc agatgtcccg
    10621 tgtgtctacc atgcggacgg ccgcgtgggc actagccgcg gcagcggcgt ctacgcgcgt
    10681 acgggcgggg cgcacacgtg ccggtcccgg tccggccccc gggtcccggc cccccgggcc
    10741 ccggtctcgc tcagtggtcc gcgagccgtg cgccgtcccg cgcgagggag gtgagccgcg
    10801 agatcgcccg gaagtacttc ttccggtagc cgccttcgag catctccttg ccgaacagct
    10861 cgtccagcgg ggatcccgag gccagcaccg gcagctcccg gtcgtagagc cggtccgcga
    10921 gcaccaccag ccgcagcgcc gtcgactggt ccggcaccgg cccgacgtcc gtcaggcaga
    10981 cggcgccgag accgtcgacg agcgccccgt aacggctcgg gtgcacggcg gccagatggg
    11041 acagcagccc ggggaaggag tcgagggagg cgccgggcgt gcggtgcgcc gcgcgcgtga
    11101 cggcgtctgc gctgagcggc tcgggcgcgg cgggcaggcc gcgatgccgg tagtcctcgc
    11161 cttcgacgcg cagcgtacgg aagtgcgcgg agaggccctg gatctcgcgg aggaagtcgg
    11221 cggcggcgaa gcggccctcg ccgagcctgc cgggcagcgt gttggacgtc gcggccagcg
    11281 ccacgccctg ctcgacgagc cggccgagga ggctggagac gagaacggtg tcgcccgggt
    11341 cgtccagctc gaactcgtcg atgcacagca gccggtggcc gcccagcgtg cgcacggtct
    11401 cctggaagcc cagagc
//
