LOCUS       NZ_JAASAG010000003     26608 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. HNM0575 scfid3, whole genome shotgun sequence.
ACCESSION   NZ_JAASAG010000003
VERSION     NZ_JAASAG010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. HNM0575
  ORGANISM  Streptomyces sp. HNM0575
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 821818)
  AUTHORS   Xiao,K.
  TITLE     New actinomycetes from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 821818)
  AUTHORS   Xiao,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-MAR-2020) College of Tropical Crops Hainan University,
            Hainan University, Renmin Avenue, HaiKou, HaiNan 570100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2018
            Assembly Method                   :: SOAPdenovo v. 1.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012726265.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 05:29:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,992
            CDSs (total)                      :: 5,923
            Genes (coding)                    :: 5,797
            CDSs (with protein)               :: 5,797
            Genes (RNA)                       :: 69
            rRNAs                             :: 5, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 126
            CDSs (without protein)            :: 126
            Pseudo Genes (ambiguous residues) :: 0 of 126
            Pseudo Genes (frameshifted)       :: 15 of 126
            Pseudo Genes (incomplete)         :: 115 of 126
            Pseudo Genes (internal stop)      :: 5 of 126
            Pseudo Genes (multiple problems)  :: 8 of 126
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 469190
            Orig. end                         :: 495798
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAASAG010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26608
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26608
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26608
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16608](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16608
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            1193..1945
                     /locus_tag="HCC61_RS10015"
                     /old_locus_tag="HCC61_10015"
     CDS             1193..1945
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983099.1"
                     /locus_tag="HCC61_RS10015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10015"
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_169134938.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.6e-11, bitscore:
                     39.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGDEESQTVLDIALA
                     NFAAVGLTDVAVVVGYRKEAVYERKEALEKKHGVKLTLVDNDKAEEWNNAYSLWCARDV
                     IKQGALLANGDTVHPVSVEKTLLDARGGDQKIILALDTVKHLDEEEMKVVTDPEKGVQQ
                     ITKLMDPATADGEYIGLTLIEPEAAEELADALKATFERDPQLYYEDGYQELVNRGFKVD
                     VAPIGDVQWVEIDNHDDLAKGREIACRY"
     gene            1933..2994
                     /locus_tag="HCC61_RS10020"
                     /old_locus_tag="HCC61_10020"
     CDS             1933..2994
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413836.1"
                     /locus_tag="HCC61_RS10020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10020"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_169134939.1"
                     /sec_met_domain="Fe-ADH (E-value: 5.6e-20, bitscore: 66.8,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 6.7e-08, bitscore:
                     27.4, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDISRGALDDLAGLLADQRISSNGKLAFAISG
                     GSGAALRERFAPALPSADWYEVGGGTIDDAIKLADSMKSGRYDAVVGLGGGKIIDCAKF
                     AAARIGLPLVAVATNLSHDGLCSPVATLDNDAGRGSYGVPNPIAVVIDLDVIREAPARF
                     VRSGIGDAVSNISAVRDWELAHTVRGEDIDGLAAAMARQAGEAVLRHPGGVGDDAFLQV
                     LAEGLVMTGISMSVAGDSRPASGACHEINHAFDLLYPKRAASHGEQCGLGAAFATFLRG
                     DREMSMLMVEVLKRHGLPVLPHEIGFDEDEFVKVTEYAPDTRPGRYTILEHLDLSADQI
                     RDAYRDYAQAIGS"
     gene            2972..3751
                     /locus_tag="HCC61_RS10025"
                     /old_locus_tag="HCC61_10025"
     CDS             2972..3751
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049651.1"
                     /locus_tag="HCC61_RS10025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10025"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_169134940.1"
                     /transl_table=11
                     /translation="MHKPSVAELRPVVHPEGVKDRRSGEHWAGRLYMREISLRMDRHLV
                     NTRVTPNQLTYLMTVAGVLAAPALLVPGVGGAVLGVVAVQLYLLLDCVDGELARWKQQF
                     SLGGVYLDRVGAYLCDAAVLLGFGLRAADLWGGGRIDWLWAFLGTLAALGAVLIKAETD
                     LVGVARHQGGLPPVKEAASEPRASGVALARKAAAALKFHRLILGIEASLLILVLAVVDE
                     IRGDLFFTRLGVAVLAGIAVVQTLLHLVSILASSRLK"
     gene            3766..4674
                     /locus_tag="HCC61_RS10030"
                     /old_locus_tag="HCC61_10030"
     CDS             3766..4674
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568725.1"
                     /locus_tag="HCC61_RS10030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10030"
                     /product="glycosyltransferase"
                     /protein_id="WP_169134941.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.2e-10,
                     bitscore: 34.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQQGPERSAQTPRLGAVVLTMGNRPEELRALLDSVAKQDGDRIE
                     TVVVGNGAPLPALPEGVRTVELPENLGIPGGRNVGIEAFGPSGAEVDALLFLDDDGLLP
                     ETDTAELVREAFAAAPSLGIISFRIADPETGETQRRHVPRLRAADPLRSSRVTTFLGGA
                     NAVRTKVIAEVGGLPDEFFYAHEETDLAWRALDAGWSIDYRADMVLHHPTTAPSRHAVY
                     HRMVARNRVWLARRNLPAPLIPVYLGVWLLLTLARRPSRPALRAWLGGFREGWTKPCGA
                     RRPMRWRTVWRLTRLGRPPVI"
     gene            4740..5684
                     /locus_tag="HCC61_RS10035"
                     /old_locus_tag="HCC61_10035"
     CDS             4740..5684
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133319.1"
                     /locus_tag="HCC61_RS10035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10035"
                     /product="ABC transporter permease"
                     /protein_id="WP_169134942.1"
                     /transl_table=11
                     /translation="MTETTHGGAVGVKPPPTPDDRLSPAELAAKYGLSVSGARPSLAEY
                     VSQLWARRHFILAFSRAKLTAQYTQAKLGQLWQVVTPLLNAAVYYLIFGLIMGGRKGIP
                     GGQDNYIPFLVTGVFVFTFSQTSVLNGVRAISGNLGLVRALHFPRASLPISISLQQLQQ
                     LLYSMIVLVVILVGFGHFPAWSWILVLPALACQFLFNTGLAMIMARLGSKTPDLAQLMP
                     FITRTWLYASGVMFFLPYQLQSKAHADPWLVDMLQANPAAVYMDLIRFAFIDGYPASTL
                     PPHVWTLALGWGLIFGIGGFVFFWKSEERYGRG"
     gene            5671..6504
                     /locus_tag="HCC61_RS10040"
                     /old_locus_tag="HCC61_10040"
     CDS             5671..6504
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907919.1"
                     /locus_tag="HCC61_RS10040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10040"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_169134943.1"
                     /transl_table=11
                     /translation="MAVAEDTQEETKTVQQQAAPAHQEPWVPTVIAEDLHIVYRVYGSA
                     KGRGSATAALNRIVRRKPGGGSVREVHAVRGVSFTAYRGQAVGLIGSNGSGKSTLLRAI
                     AGLLPAESGRVYTNGQPSLLGVNAALMNDLTGERNVVLGGLAMGMSRDEVAERYQGIVD
                     FSGINEKGDFITLPMRTYSSGMSARLRFSIAAAKNHDVLMIDEALATGDKKFQRRSEQR
                     VRELREEAGTVFLVSHNNKSIRDTCERTLWLEKGELVHDGPTEEVLKEYEKFTGK"
     gene            complement(6590..8857)
                     /locus_tag="HCC61_RS10045"
                     /old_locus_tag="HCC61_10045"
     CDS             complement(6590..8857)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006344874.1"
                     /locus_tag="HCC61_RS10045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10045"
                     /product="MMPL family transporter"
                     /protein_id="WP_169134944.1"
                     /transl_table=11
                     /translation="MLRRIAELALRRPRALLVLGLVAVVAMGAVGFGAFGKLQAGGFED
                     PDAPSSRARTLIADEFGGEQNLVLLVSADSGDGSLKQAPVRKAGEKLTEELREAPQLSH
                     VSSYWDAGGSALTSRDGSQALVLAHVKGDSSQVADRTEEITDKWSGDRGPVHVRAGGGA
                     ALNNDISGQVSADLAVAESIAVPLTLVLLVIAFGSFVAALLPLAIGLIAILGTFAELFV
                     LGSVTDVSVFAVNLTTALGLGLGIDYGLLIVSRFRERLSAGDQVGDALRTTVTTAGRTI
                     AFSAATVVAALAALLLFPPFFLRSFAYAGIGVVAVAALAALIFVPALLAVLGHRVNKGR
                     LPWADAVRRPDAPVWGRLARTAMRRPALTALPVLAVLLLAASPLLGARFGMPDERVLPE
                     DAQSRQVSTALARDFPGGSTESVQIVTTAGVPRDGLDEYAGRISRLDGVARVEASSGVY
                     ADGRAAPAGRAQSALGKPDAELLNVVPEAGSDAGKRQDLVRGIRALEAPGSGEALVGGR
                     DAQLVDTKASIGDRLPGAIGMVVGTTFVLLFLFTGSVVQPLRALVLNTVSLTASIGAMV
                     WIFQDGHLSGVLGFTAMPMDTSMTVLMFCIVFGLSMDYEVFVTSRIKELHDAGADNATA
                     VARGLSRTGRIVTMAAGLLAVSFFAFATGEIGFLQMFGLGSGLAILIDAVAVRGVLVPA
                     AMRLLGRGAWYAPRVLRRLHGRVGLAESAVPPRTSPEEEPGAAAGAGAEREEAQPRTGA
                     GV"
     gene            8958..9752
                     /locus_tag="HCC61_RS10050"
                     /old_locus_tag="HCC61_10050"
     CDS             8958..9752
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037627.1"
                     /locus_tag="HCC61_RS10050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10050"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_240968746.1"
                     /transl_table=11
                     /translation="MADMEAKTGASAARTGGDVPEEERPARGAGSGRKGGKGAYHHGDL
                     RNALIGAATDLARDGGPEAVVLRAAARRVGVSPTAAYRHFAGQAELLHAVKEFGQERLA
                     DRMEAGGRAASDDGDTPEAAEARMRALGHGYLSFALAEPGLYRVAFCRDPLPLGPPPGV
                     AVPGAGGGEQDAGPAWEFRSFEILVRALDDLVEQGRMPAERRTGAEVTAWATVHGLAML
                     CLDGPLAQASPEEIDAVAERAFDVLIAGFTAPSAPPAPSARH"
     misc_feature    complement(9961..9976)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     gene            10001..10912
                     /gene="hpnC"
                     /locus_tag="HCC61_RS10055"
                     /old_locus_tag="HCC61_10055"
     CDS             10001..10912
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018853729.1"
                     /locus_tag="HCC61_RS10055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10055"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_346777112.1"
                     /sec_met_domain="phytoene_synt (E-value: 4e-38, bitscore:
                     126.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.6e-40,
                     bitscore: 133.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAEADAHARAVLAKATRENFPVAPGFLPREWRYDLMAVYGYARL
                     VDDIGDGDLAPGGLDAQYLGLGPGEESRPGPDRLSMLDALEADLLALFDDARPAPGHPL
                     LRALVPTLRRRDLTPEPFLALIEANRQDQKVRRYADHAELLGYCELSANPVGHLVLAIT
                     GAATPERIRYSDDVCTALQIVEHLQDVAEDLGRDRIYLPAEDMARFHVTESDLAAPRAN
                     ASVRALLAYEADRARALLSAGDPLVASVRGRLRLLLAGFTGGGRATLRAISRAGYDVLP
                     GPPRATTRGLLREVAATLRREG"
     gene            10920..11861
                     /gene="hpnD"
                     /locus_tag="HCC61_RS10060"
                     /old_locus_tag="HCC61_10060"
     CDS             10920..11861
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358584.1"
                     /locus_tag="HCC61_RS10060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10060"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_169134946.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.1e-60, bitscore:
                     199.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.2e-67,
                     bitscore: 223.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRARPVPYVPPPVAAAYDYCESVTGQQARNFAYGIRLLPSGKRR
                     AMSALYAFSRRVDDIGDGPLPRSVKVARLEETRELLGRIRDGGIEQDDTDPVAVALADA
                     ARRYPVPMDGLDELIDGVLLDVHGTAYGSWEELEVYCRCVAGAIGRLSLGVFGTLPGVS
                     DTDRASEYADTLGLALQLTNILRDLREDAEHGRTYLPAEDLEKFGCSADFRNGQAQPGS
                     DFRGLMHHEVQRARALFARGYRLLPLLDRRSGACVAAMAGIYQRLLERIAADPYAVLSE
                     RVSLPNRQKAYVAVRGLTGIDARFAARRSTRT"
     gene            11858..13447
                     /gene="hpnE"
                     /locus_tag="HCC61_RS10065"
                     /old_locus_tag="HCC61_10065"
     CDS             11858..13447
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019546753.1"
                     /locus_tag="HCC61_RS10065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10065"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_169134947.1"
                     /sec_met_domain="DAO (E-value: 3.1e-09, bitscore: 32.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGGERTTHSRRDVHGPRGAVVVGGGIAGTTAALRLADAGVPTTL
                     LESRPRLGGLAFSFHRDSPAGRLTVDNGQHVHLRCCTAYTWFLERIGGAGLAPLQRRLD
                     VPVLDVAPERPRLARLRRNSLPVPLHLASGLACYRHLTAGERSRAARAALALRGLDPAD
                     PALDDVDFATWLHGQGQSDRAIRALWDLVGTATLNARAPHASLGLAAKVFRTGLLSEPG
                     GADIGVSRVPLGHLHDTLAGRALRAAGVRVRTQARARAVTAAPGGGWTVHAEHGQGSAA
                     QHREHRADAVVLAVPQHEAHDLLPEGALPAPGRLLEIGTAPILNLHVVYDRPVLRRPFF
                     AALGSPVQWVFDRTGPAGLGRGQYLAVSQSAAQQEIDRPVAALRERYLPELARLLPAAR
                     TARVLDFFVTRERAATFDPRPGVGRLRPAARTSAPGVCLAGAWTDTGWPATMESAVRSG
                     TTAAREALTAVGSTYDNDPVPGTTRKGGGMSSADQGGTSGGPRRTAQHQPPTPAPRAAV
                     PPRAAPNAEETP"
     gene            13444..14514
                     /locus_tag="HCC61_RS10070"
                     /old_locus_tag="HCC61_10070"
     CDS             13444..14514
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888995.1"
                     /locus_tag="HCC61_RS10070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10070"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_169134948.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9.6e-62, bitscore:
                     204.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTANQHSVVDNASVSALLERGRRLATPLLRAAVDRLAPPMDTVA
                     AYHFGWIDESGRPSEAHGGKAVRPALALLSAEAAGAAPETGLPGAVAVELVHNFSLLHD
                     DLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALANEILLEPGTPEAGRATRRLTRATR
                     RLIDGQAQDISYEHREEVTVEECLEMEGNKTGALLACAVSIGAVLGGADDRTADALESY
                     GYHLGLAFQAVDDVLGIWGDPEATGKQAWSDLRQRKKSLPVVAALASPDPAATRLAELM
                     RTDAKKSQAEFEDFDEAEFATRAALIEEAGGREWTSAEAQRQHSTALAALGPLDMPGHV
                     RDQLTALADFVVVRQR"
     gene            14566..16608
                     /gene="shc"
                     /locus_tag="HCC61_RS10075"
                     /old_locus_tag="HCC61_10075"
     CDS             14566..16608
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031166.1"
                     /locus_tag="HCC61_RS10075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10075"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_169134949.1"
                     /sec_met_domain="T2TS (E-value: 1.7e-143, bitscore: 474.4,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDTGTGATAPATATTPPTDGAEQAREAGSLADRAARAAALA
                     SEHLLDRQDAAGWWKGDLETNVTMDAEDLLLREFLGVRDETTTREAARHVRAQQRDDGT
                     WATFHGGPGDLSTTIEAYVALRLAGDDPHAPHMERASAWVREQGGVASSRVFTRIWLAL
                     FGWWRWADLPEMPPEMIWFPKWFPLNIYDFGCWARQTIVPLTVVCAKRPVRAAPFSLDE
                     LHRDPGRPNPPRPMAPAASWEGFFQRLDRTLHAYRRVASRSLRRAALRSAARWIVERQE
                     NDGCWGGIQPPAVYSLIALRLLGYDLDHPVMRAGLESLDRYTVRYETAGGEDGGQKAEG
                     GTARMVEACQSPVWDTCLATIALADAGLPADHPALVKAADWMLGEQVLRPGDWSVRKPQ
                     LPPGGWAFEFENDNYPDADDTAEVVLALRRVRHHDQARVDTAVRRAVRWSLGMQSRSGA
                     WGAFDADNDSPFPNRLPFCDFGEVIDPPSADVTAHMVEMLAAEGRGDDPRVRRAVSWLL
                     SEQEVGGAWFGRWGVNYVYGTGSVVPALVAAGLPASHPAVRRAVGWLESVQNGDGGWGE
                     DLRSYRPGHEREWAGRGTSTASQTGWALLALLAAGERESMAVEQGVSWLARTQREDGSW
                     DEPHFTGTGFPWDFSINYHLYRQVFPLTALGRYLYGTGTGPQEER"
     gene            16605..17279
                     /locus_tag="HCC61_RS10080"
                     /old_locus_tag="HCC61_10080"
     CDS             16605..17279
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100142.1"
                     /locus_tag="HCC61_RS10080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10080"
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_169134950.1"
                     /transl_table=11
                     /translation="MTDSGDRGPLLIACALGIERLALRRLGVSPYGADAADGTGGPVTV
                     LRTGMGPRAAERAVERALRDEREPGGTAVVATGFCAGLMPGLHPGDLVVADETRDAAGR
                     TQCTGTQLLADALRPYGTVHVGPLAGSAHIVRGPARAALHAATAAVAADMESAATLRTA
                     ARTGPAGRQRPVAAVRVVVDAPGHELIRPGTLRGGISAFRVLRGVMPAFLEWHRSLLLP
                     WR"
     gene            17287..18300
                     /gene="hpnH"
                     /locus_tag="HCC61_RS10085"
                     /old_locus_tag="HCC61_10085"
     CDS             17287..18300
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944199.1"
                     /locus_tag="HCC61_RS10085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10085"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_169134951.1"
                     /sec_met_domain="PF04055 (E-value: 3.4e-18, bitscore: 62.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 7.6e-09, bitscore: 30.7,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQTVRIGSYLFQQKLRGREKFPLIVELEPLFACNLKCEGC
                     GKIQHPAGVLKQRMPVAQAVGAVTESGAPMVSIAGGEPLMHPQIGEIVRQLVAKRKYVF
                     LCTNAMLLRKKLDEFTPSRYFAFAVHIDGLRERHDESVAKEGVFDEAVEAMKEAKRRGF
                     RVTTNSTFFNTDTPQTVIEVLDYLNDELKVDEMMVSPAYAYEKAPDQEHFLGVEQTREL
                     FRKAFAGGNRRRWRLNHSPLFLDFLEGKADFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELVEETDWEAYGRGRDPRCANCMAHCGYEPTAVLATMSSLKESLRAARDTVRA"
     gene            18404..19786
                     /locus_tag="HCC61_RS10090"
                     /old_locus_tag="HCC61_10090"
     CDS             18404..19786
                     /NRPS_PKS="Domain: Aminotran_3 (40-362). E-value: 7.9e-89.
                     Score: 289.9. Matches aSDomain:
                     nrpspksdomains_HCC61_RS10090_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358578.1"
                     /locus_tag="HCC61_RS10090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10090"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_169134952.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.2e-88, bitscore:
                     292.9, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDFDLKELLAQRAAERYELHARHLNHQQPRMLRTIGFDKVYERA
                     EGALLFDADGNDYLDMLAGFGVMGIGRHHPVVRQALHDVLEAQLADLTRFDCPPLPGLL
                     AERLLALAPGMERVYFGNSGTEAVETALKFARCATGRSRVLYCDHAFHGLTAGSLSVNG
                     EAAFRRGFGPLLPDTAVPLGDLAALERELRKGEVAALIVEPIQGKGVHAAPPGYLAAAG
                     ELLRRHGALLIVDEVQTGLGRTGDFFAYQHEPDVRPDLVCVAKALSGGYVPVGATLGKE
                     WIFKKVYSSMDRVQVHSASFGANAQAMAAGLATLAVLENEDLTARARRTGENLRDRLAA
                     LVGEYEMLHEVRGRGLMIGIEFGKPKSLGLRGRWTMLQAARKGLFAQMVVVPLLQRHRI
                     LTQVSGDELEVIKLTPPLVIGEADADRFVRAFKEIMDEAHDGGGLMWEFGRNLIRHAAA
                     NR"
     aSDomain        18524..19489
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HCC61_RS10090_Aminotran_3.1"
                     /evalue="7.90E-89"
                     /label="HCC61_RS10090_Aminotran_3.1"
                     /locus_tag="HCC61_RS10090"
                     /protein_end="362"
                     /protein_start="40"
                     /score="289.9"
                     /tool="antismash"
                     /translation="VYERAEGALLFDADGNDYLDMLAGFGVMGIGRHHPVVRQALHDVL
                     EAQLADLTRFDCPPLPGLLAERLLALAPGMERVYFGNSGTEAVETALKFARCATGRSRV
                     LYCDHAFHGLTAGSLSVNGEAAFRRGFGPLLPDTAVPLGDLAALERELRKGEVAALIVE
                     PIQGKGVHAAPPGYLAAAGELLRRHGALLIVDEVQTGLGRTGDFFAYQHEPDVRPDLVC
                     VAKALSGGYVPVGATLGKEWIFKKVYSSMDRVQVHSASFGANAQAMAAGLATLAVLENE
                     DLTARARRTGENLRDRLAALVGEYEMLHEVRGRGLMIGIEF"
     gene            complement(19819..20610)
                     /locus_tag="HCC61_RS10095"
                     /old_locus_tag="HCC61_10095"
     CDS             complement(19819..20610)
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019546747.1"
                     /locus_tag="HCC61_RS10095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10095"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_169134953.1"
                     /transl_table=11
                     /translation="MSQQSTEPTLTGVRNFRDVGGVPTADGRRLRHGVLFRSGHLAHAT
                     PEDARFLGGLGLHTVFDFRNSADQALEGPDVELPGVRNLNIPLSDPADGAEFWKMVRDG
                     ELDQLRTVLADGQGAARMIASYRSMIKNRTAEHSRILHTLAEDSVPALMHCAAGKDRAG
                     LSVAVTLMAVGVDQEAIEADYLRSNSPHRRYKMHRGAKGEVSPEVAELLSPLFDARAAY
                     LAAAMTTIEETWGGVERYLTEGLGLDRATRERLQERMLEDG"
     misc_feature    complement(20882..20895)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.94"
                     /tool="antismash"
     misc_feature    21184..21196
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            21637..23535
                     /locus_tag="HCC61_RS10100"
                     /old_locus_tag="HCC61_10100"
     CDS             21637..23535
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907906.1"
                     /locus_tag="HCC61_RS10100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10100"
                     /product="ATP-binding protein"
                     /protein_id="WP_240968749.1"
                     /transl_table=11
                     /translation="MVRLAVFPASVIAVAGAAVVAYVMTAEGSIRASGAPARGDGGLVL
                     WIVLAAALLLVCGVIVVAAHSATVQARRALERQTELRRSVARGRSDIRALLSSLEQGAR
                     PRPRPLPALPEPDVQADAFELLAHELAHAQHSAETAVTEAVALVRSNSSGSEEKVEVFV
                     NLARRLQSLVHREIELLDELENEVEDPDLLKGLFHVDHLATRIRRHAENLAVLGGAVSR
                     RQWSRPVTMTEVLRSSIAEVEQYPRVKLVPPIEGTLRGHAVADVIHLLAELVENATVFS
                     APQTQVLLRAQHVTAGLAIEVEDRGLGMPAAEQNRMNAVLSDPERIDVGELLQDGRIGL
                     FVVSALAQRHGIVVQLQSNIYGGIQAVLVLPREVLGDEPASPVEQSGAAVATGTAAARN
                     GAARMPHARTESTEHPLPAAPEGARQPQPPLQPQASLHSQDPLQSQASQDPLQSQEGAH
                     PQSRPLPEPRSRSEAHAHAQSQSQSQLGSRAQSGADDSTAPSPAAASYSPPRPGAEPRL
                     PGHSRRQTSAPASQPATAAVNGERPELPRRRRQEHLAPELREAPPARGGEPGGTSWDAT
                     TQGHDPGLMAAFQRGTSRAEESDGDAAGPGPGPDAGASTGMSTGTSTGNEAPHPAD"
     misc_feature    21796..21798
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            23742..24158
                     /locus_tag="HCC61_RS10105"
                     /old_locus_tag="HCC61_10105"
     CDS             23742..24158
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006141014.1"
                     /locus_tag="HCC61_RS10105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10105"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_169134954.1"
                     /transl_table=11
                     /translation="MVSEAPIGHSADLSWLLTGLVQRVPHTRSALLLSSDGLVKAVHGL
                     ETDTADHMAALASGLYSLARSAGVRLGDGGDVRQVVVELDTSLLFVSTAGQGACIAVLA
                     GRDADAAVLGYEMAMLVKSVRPYLGTPARQPAGH"
     gene            24167..24553
                     /locus_tag="HCC61_RS10110"
                     /old_locus_tag="HCC61_10110"
     CDS             24167..24553
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763719.1"
                     /locus_tag="HCC61_RS10110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10110"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_169134955.1"
                     /transl_table=11
                     /translation="MRRRQPSEVPLLDDDAGRLIRPYTVSNGRTKPSAQFDLLTMVMAT
                     GDRPYSYLGPDHSHVLKLCGGPVSVAEIAAQIAQPAVVTKVLLSDLVDCGAITSRAPGR
                     APLGNDPTDRQLLEAVLDGLRRRL"
     gene            24531..25136
                     /locus_tag="HCC61_RS10115"
                     /old_locus_tag="HCC61_10115"
     CDS             24531..25136
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994207.1"
                     /locus_tag="HCC61_RS10115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10115"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_169134956.1"
                     /transl_table=11
                     /translation="MGSVDDSEASRADPFPAALKILIAGGFGVGKTTFVGAVSEIEPLS
                     TEELLTQVSAATDSLEGVEDKATTTVAMDFGRITLSASHMLYLFGTPGQERFWFMWNEL
                     SEGALGAVVLADTRRLEHCFAAVDFFERRGITFIVAVNEFDNSYHYGPDEVRAAIDLKP
                     DVPVVLCDARESRSATQVLVSLVQHLINTRSSHGTDVV"
     gene            25126..25701
                     /locus_tag="HCC61_RS10120"
                     /old_locus_tag="HCC61_10120"
     CDS             25126..25701
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944162.1"
                     /locus_tag="HCC61_RS10120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HCC61_10120"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_169135241.1"
                     /transl_table=11
                     /translation="MSFDPTSHLLLTPEDTEAPNRVVRLRELGLGEAPVPEFDDFARHL
                     ARVTGAPYAMVNFIDEERQYFAGLYAPGSDQAVELNPGSGAGADASVGRVMARDHGYCP
                     HVIVRRKALVLEDVCDYPRFAGNPVVDEIGIRSYLGAPLIDRTGMALGTVCVVDQEPRP
                     WGRQGLETIKSMAADLVEQIHRREHQGP"
ORIGIN
        1 tgctgctgat cgcctccttc gtgctggacg cgaccgacgg ccagctcgcc cgctacgacc
       61 tccagtactc caccctcggc gcgtggctcg acgccacctt cgaccgcgcc aaggagtacg
      121 cctactacgc gggtctcgcc ctcggcgcct cccgcggcgg cgacgacgtg tgggggctgg
      181 cgctcggcgc gatggtgctc cagaccgtgc gccacgtcgt cgacttctcc ttcaacgagg
      241 ccaaccacga cgccgccgcc aacaccagcc ccaccgccgc gctctccagc cgcctcgaca
      301 gcgtcggctg gacggtctgg ctgcgccgca tgatcatcct gccgatcggt gaacgctggg
      361 cgctgatcgc ggtgttgacc gcctgcacca ctccccgcat caccttcgtc gtgctcctga
      421 tcggatgcgc gctcgccacc tgctacacca ccgcgggccg cgtgctgcga tccctcacca
      481 ggaaggcccg ccgtaccgac cgcgccgcac aggccctggc cgacctcgcc gacagcggac
      541 cgctcgccgg gagcttcgcg gccctgaccc gccgcgcgca catccgcttg ccggggttcg
      601 ggcctccggc cgtcgccctc ctcggcacgg ccgtgctgtt ggccaccgcg ctgtggacgc
      661 ccctgggtag cgtctggacg tgcctggccg ccctcttgta cgccctgacc tcgggcatcg
      721 ccgtcgccgc ccaactgcgg ggcgcactgg actggctcgc gccgcccttc ttccgtaccg
      781 cggaatacgt gctcgtgctc gtcctcgcgc tacgcgcgga ccaagcaggg gtgaacggcg
      841 cgctgcccgc cgctttcggc ctggtggcgg cggtcgccta ccatcactac gacacggtgt
      901 accgcattcg cggcggcacc ggcgcgcctc cgcactggct tgtacgtgcg accgggggtc
      961 acgaaggacg agccctggcc gtaaccctcg ccgcggccct ctgggcggcc ggcgacggcg
     1021 gcacggaccg ggcggggccg ggccagagtc cggtccaagg accgggccaa ggtttcacca
     1081 tcgcgctgac cacgctcgcc gtggccatcg cggcagtggt gctcgtcgag agcatccgct
     1141 tctgggtgtc ctccaaagca cccgccgtac acgacgaaac aggagaaccc gcatgatcgg
     1201 cctcgtgctg gccgccggcg ccggacggcg tctgcgcccc tacaccgaca ctctccccaa
     1261 ggccctcgtg ccggtgggcc ccgagggcga cgaggagtcc cagaccgtcc tcgacatcgc
     1321 cctcgccaac ttcgccgccg tcggcctcac cgacgtcgcc gtcgtcgtcg gctaccgcaa
     1381 ggaggccgtg tacgagcgca aggaggccct ggagaagaag cacggggtca agctcaccct
     1441 cgtcgacaac gacaaggccg aggagtggaa caacgcctac tccctgtggt gcgcccgcga
     1501 cgtcatcaag cagggcgcgc tgctcgccaa cggcgacacc gtccaccccg tctccgtgga
     1561 gaagaccctc ctcgacgccc gcggcggcga ccagaagatc atcctcgccc tcgacacggt
     1621 caagcacctc gacgaggagg agatgaaggt cgtcaccgac cccgagaagg gcgtccagca
     1681 gatcaccaag ctgatggacc cggccaccgc cgacggcgag tacatcggtc tcaccctcat
     1741 cgagcccgag gccgccgagg agctggccga cgccctgaag gccaccttcg agcgcgaccc
     1801 gcagctgtac tacgaggacg gctaccagga gctggtcaac cgcggcttca aggtggacgt
     1861 ggcgccgatc ggcgacgtgc agtgggtcga gatcgacaac cacgacgacc tcgccaaggg
     1921 ccgggagatc gcatgccggt actgacccgc ctcatcccgt cgcccgtcgt cgtcgacatc
     1981 agccgcggcg ccctggacga cctggcgggc ctgctggccg atcagcggat ctcctcgaac
     2041 ggcaagctcg ccttcgccat cagcggtggt tcgggcgcgg ctctgcgtga gcgcttcgcc
     2101 cccgcccttc ccagtgccga ctggtacgag gtcggcggcg gcaccatcga cgacgccatc
     2161 aagctcgccg actccatgaa gtccgggcgc tacgacgcgg tcgtgggcct gggcggcggc
     2221 aagatcatcg actgtgcgaa gttcgcggcc gcgcgcatcg gactgccact ggtcgccgtg
     2281 gccaccaacc tcagccacga cggcctgtgt tcgccggtcg ccacgctcga caacgacgcc
     2341 ggccgcggtt cgtacggcgt gcccaacccg atcgccgtcg tcatcgacct cgacgtcatc
     2401 agggaggcgc ccgcccggtt cgtacgctcc gggatcggcg acgccgtctc caacatctcc
     2461 gccgtacggg actgggagct cgcccacacc gtgcgcggcg aggacatcga cggcctcgcc
     2521 gccgccatgg cccgtcaggc gggagaggcg gtgctgcgcc accccggcgg cgtcggcgac
     2581 gacgcgttcc tccaagtcct cgccgagggc ctggtgatga ccgggatctc catgtcggtc
     2641 gccggcgaca gccgcccggc gtcgggcgcc tgccacgaga tcaaccacgc cttcgacctg
     2701 ctctacccca agcgcgcggc cagccacggc gaacagtgcg gtctgggagc ggcgttcgcc
     2761 acgttcctgc gcggcgaccg ggagatgtcg atgctgatgg tcgaggtgct caagcgccac
     2821 ggccttcccg tattgcctca cgaaatcggc ttcgacgagg acgagttcgt gaaagtgacg
     2881 gagtacgcac cggacacccg gcccgggcgg tacaccattc tcgaacacct cgacctgtcc
     2941 gccgaccaga tcagggacgc ataccgcgac tatgcacaag ccatcggtag ctgaactccg
     3001 cccggtcgtt caccccgagg gcgtgaagga ccggcgcagc ggtgagcact gggccgggcg
     3061 gctctacatg cgcgagatct ccctgcgcat ggaccggcat ctggtgaaca cgcgggtcac
     3121 gccaaaccag ttgacctacc tgatgacagt cgcgggcgtc ctcgccgccc cggccctgct
     3181 ggtgccgggg gtcggcgggg cggtgctcgg ggtggtcgcg gtccagctct acctgctgct
     3241 cgactgcgtg gacggggagc tggcccgctg gaagcagcag ttctcgctcg gaggcgtgta
     3301 cctggaccgg gtcggcgcct acctgtgcga cgccgcggtg ctgctgggct tcggcctgcg
     3361 cgccgccgac ctgtggggcg gtggccggat cgactggctg tgggccttcc tgggcacgct
     3421 cgccgcgctc ggcgccgtac tgatcaaggc cgagaccgac ctggtcggcg tcgcccgcca
     3481 ccagggcggg ctgccgcccg tgaaggaggc cgcgagcgag ccgcgtgcgt ccggtgtggc
     3541 gctggcccgc aaggccgccg cggcgctgaa gttccaccgg ctgatactcg ggatcgaggc
     3601 ctcgctgctg atcctggtcc tggcggtcgt ggacgagatc agaggggacc tcttcttcac
     3661 caggctcggt gtcgccgtgc tcgcgggcat cgccgtcgtg cagacgctgc tgcatctggt
     3721 gtccatcctc gcctccagca ggctcaagtg acggagggag ccctcatgcc gcagcagggc
     3781 ccggagcgtt ccgcgcagac gccgaggctg ggagccgtcg tgctgacgat gggcaaccgg
     3841 ccggaggagc tgcgggcgct gctcgactcc gtcgccaagc aggacggcga ccgcatcgag
     3901 accgtcgtgg tcggtaacgg cgcgccgctg cccgccttgc ctgaaggtgt acggacggtc
     3961 gagcttccgg aaaatctcgg catccccgga ggccgcaacg tcggcatcga ggccttcggc
     4021 ccgtccggcg ccgaggtcga cgcgctgctc ttcctcgacg acgacggcct gctccccgag
     4081 acggacaccg ccgagctggt gcgcgaggcc ttcgccgccg ccccgtcgct gggcatcatc
     4141 agcttccgca tcgccgaccc cgaaaccggc gagacccagc gccgccacgt gcccaggctg
     4201 cgcgccgcgg atccgctgcg ctcctcccgg gtcacgacgt tcctgggcgg cgccaacgcc
     4261 gtgcgtacga aggtcatcgc cgaagtcggc ggcctgcccg acgagttctt ctacgcacac
     4321 gaggagacgg acctggcctg gcgggccctg gacgcgggct ggtcgatcga ctaccgcgcc
     4381 gacatggtgc tgcaccatcc gaccaccgcc cccagcaggc acgcggtcta ccaccgcatg
     4441 gtcgcccgca accgggtctg gctggcccgc cgcaacctgc cggcccccct gatccccgtc
     4501 tatctcggtg tctggctgct cctcaccctc gcccgccggc cctcgcgccc ggccctgcgc
     4561 gcgtggctcg gcggattccg ggaggggtgg accaaaccgt gcggggcccg caggcccatg
     4621 cggtggcgta cggtgtggcg cctgacccga ctaggtcgcc cgccggtgat ctgacaagct
     4681 cgtctccagc accaccctct ccctgttcag ctgcgcgtgt gaggacgaaa gtttccaacg
     4741 tgaccgagac aacgcacggt ggtgcggtgg gcgtgaagcc cccgcccaca ccggacgacc
     4801 gtctgtcccc ggccgagctc gcggccaagt acggcttgtc ggtgagcggg gcgcgcccct
     4861 cgctggcgga gtacgtgagc cagttgtggg cccggcgcca cttcatcctc gccttctccc
     4921 gggcgaagct cacggcccag tacacccagg cgaaactggg gcagctgtgg caggtcgtca
     4981 cgcctctgct caacgccgcg gtctactacc tcatcttcgg gctgatcatg ggcggccgta
     5041 agggcatccc gggcggtcag gacaactaca ttccgttcct cgtgacgggt gtgttcgtct
     5101 tcaccttcag ccagacctcg gtgctcaacg gcgtccgcgc gatctccggc aacctgggcc
     5161 tggtccgagc gctgcacttc ccgcgggcct cgctgccgat ctccatctcg ctacagcagc
     5221 tccagcagct gctgtactcg atgatcgtgc tggtggtcat cctcgtgggc ttcgggcact
     5281 tcccggcctg gtcatggatc ctggtcctgc cggctctggc ctgccagttc ctgttcaaca
     5341 ccggcctggc catgatcatg gcgaggctgg gcagcaagac cccggacctg gcgcagctga
     5401 tgccgttcat cacgcggacc tggctgtacg cgtcgggcgt gatgttcttc ctgccgtacc
     5461 agcttcagtc gaaggcccac gccgatccgt ggctcgtcga catgctccag gcgaacccgg
     5521 ccgccgtgta catggacctg atccgcttcg ccttcatcga cggatacccg gcctcgaccc
     5581 tgccgccgca cgtctggacg ctggccctcg gctggggcct gatcttcggg atcggcggat
     5641 ttgttttctt ctggaagtcg gaggagcgtt atggccgtgg ctgaggacac ccaggaggag
     5701 acgaagacgg tccagcagca ggcggctccc gctcaccagg agccgtgggt tcccaccgtc
     5761 atcgccgagg acctgcacat cgtctaccgc gtctacggca gcgcgaaggg caggggcagc
     5821 gcgacagcgg ctctgaaccg catcgtgcgc cgcaagccgg gcggcggcag cgtccgcgag
     5881 gtgcacgcgg tcaggggcgt cagcttcacc gcctaccgcg gccaggccgt cggcctcatc
     5941 ggctccaacg gctcgggcaa gtcgacgctg ctgcgcgcca tcgcgggtct gctgcccgcc
     6001 gagagcggcc gcgtctacac caacggccag ccgtcgctgc tgggcgtcaa cgcggcgctg
     6061 atgaacgacc tcaccggcga gcggaacgtc gtgctcggcg ggctcgcgat gggcatgtcc
     6121 cgcgacgagg tcgccgagcg ctaccagggg atcgtcgact tctccgggat caacgagaag
     6181 ggcgacttca tcacgctccc gatgcgcacg tactcctccg gtatgtcggc gcggctccgg
     6241 ttctccatcg ccgccgccaa gaaccacgac gtgctgatga tcgacgaggc gctggcgacg
     6301 ggcgacaaga agttccagcg gcgctcggag cagcgcgtcc gcgagctgcg cgaggaggcg
     6361 ggcaccgtct tcctcgtcag ccacaacaac aagtcgatcc gcgacacgtg cgagcggacg
     6421 ctgtggctgg agaagggcga gctggtccac gacgggccga ccgaggaagt gctcaaggag
     6481 tacgagaagt tcacgggcaa gtagcgcccg gctccctcct ccccggacgg cagcggccgg
     6541 ccgggacctc cacgggtccc ggccggccgc ttctcgcgaa ggtgccgcgt cagacgcccg
     6601 cgcccgtacg cggctgcgcc tcctcccgct ccgctccggc gccggctgcc gcccccggtt
     6661 cctcctccgg actcgtacgc ggcggaacgg ccgactccgc gagccccacc ctgccgtgca
     6721 gcctgcgcag cacgcggggc gcgtaccagg caccgcggcc cagcagccgc atcgcggcgg
     6781 gtacgagcac cccgcgcacg gcgaccgcgt cgatgaggat ggccagtccg ctgcccagcc
     6841 cgaacatctg gaggaagccg atctcgccgg tggcgaaggc gaagaagctc accgccagca
     6901 gccccgccgc catcgtcacg atgcgcccgg tgcgcgagag cccgcgtgcc acggccgtcg
     6961 cgttgtccgc ccccgcgtcg tgcagctcct tgatgcggct ggtgacgaac acctcgtagt
     7021 ccatggagag tccgaagacg atgcagaaca tcagcaccgt catcgaggtg tccatgggca
     7081 tcgccgtgaa gcccagcacc ccggagagat gcccgtcctg gaagatccac accatcgcgc
     7141 cgatggacgc ggtgaggctc accgtgttca gcaccagcgc acgcagcggc tgtacgacgc
     7201 tgcccgtgaa gaggaagagc agcacgaagg tcgtgccgac gaccatgccg atcgcgcccg
     7261 gcagccggtc gccgatcgac gccttggtgt cgacgagctg ggcgtccctc ccgccgacca
     7321 gcgcctcacc gctgccgggg gcctccaggg ctcggatgcc gcgcaccagg tcctggcgct
     7381 tcccggcatc cgagcccgcc tccggaacga cgttcagcag ctccgcgtcc ggcttgccca
     7441 gcgcggactg tgcccgtccg gccggtgcgg ccctcccgtc ggcgtagacg ccgctgctcg
     7501 cctcgacacg ggccacgccg tccagccgcg agatccgtcc cgcgtactcg tcgagcccgt
     7561 cccgcggcac ccccgccgtg gtcacgatct gcacggactc ggtcgaaccg ccggggaagt
     7621 ccctcgccag cgcggtgctc acctgcctgc tctgcgcgtc ctcggggagc acgcgctcgt
     7681 ccggcatccc gaagcgggcg cccagcagcg ggctcgccgc gagcagcagc accgcgagca
     7741 cgggcagcgc cgtgagcgcc gggcggcgca tggccgtacg cgcgagccgg ccccacaccg
     7801 gtgcgtccgg gcgccgtacg gcatcggccc acggcagccg ccccttgttc acgcggtgcc
     7861 cgagcaccgc cagcagcgcc ggtacgaaga tgagcgccgc gagggccgcg acggcgacga
     7921 ccccgattcc ggcgtaggcg aacgagcgca ggaagaaggg cgggaagagc agcagcgccg
     7981 ccagcgccgc gacgaccgtg gccgcggaga aggcgatcgt gcgcccggcc gtcgtcacgg
     8041 tcgtacgcag cgcgtccccg acctggtcgc ccgccgagag ccgttcgcgg aagcggctga
     8101 cgatcagcag tccgtagtcg atcccgaggc cgagccccag tgcggtggtg aggttgacgg
     8161 cgaagaccga gacgtccgtg acactgccga gcacgaacag ctcggcgaag gtgccgagga
     8221 tcgcgatcag cccgatcgcc agcggcagca gtgccgccac gaagctgccg aaggcgatca
     8281 cgagcagcac gagcgtgagc ggcaccgcga tcgactccgc gacggcgagg tccgcggaga
     8341 cctgcccgga gatgtcgttg ttgagggccg cgccgccgcc cgcccgcaca tgcaccggtc
     8401 cgcggtcacc gctccacttg tcggtgatct cctcggtgcg gtcggcgacc tggctgctgt
     8461 cgcccttcac gtgcgcaagt acgagcgcct gcgagccgtc ccgtgaggtg agcgccgagc
     8521 cgcccgcgtc ccagtaggag gagacgtggg agagctgcgg cgcctccctc agctcttccg
     8581 tcagcttctc gccggccttg cgcaccgggg cctgcttcag gctcccgtct ccgctgtcgg
     8641 cactcaccag cagtacgagg ttctgctcgc ccccgaactc gtcggcgatc agagtccgcg
     8701 cgcggctcga cggggcgtcg ggatcctcga agccgcccgc ctggagcttg ccgaaggcgc
     8761 cgaacccgac ggctcccatg gccacgacgg cgacgaggcc gagtacgagc agggctctgg
     8821 gccggcgcag ggccagttcc gcgattcttc gtagcactgt attgctcccc cctgaggcgt
     8881 gaacaccgat gtttacggcg taaacttgga ctcttgcagg ggatgttaat gctgtcaaca
     8941 tcgagcagga tgaaagcatg gcggacatgg aggcgaagac cggcgcgagt gccgcacgga
     9001 ccggagggga cgtgccggaa gaggagcggc ccgcacgcgg cgccggcagc ggccgcaagg
     9061 gaggcaaggg cgcctaccac cacggagacc tgcgcaacgc cctgatcggc gcggccaccg
     9121 acctcgcccg tgacggcggc cccgaggccg tcgtgctgcg cgccgccgcc cggcgcgtgg
     9181 gcgtctcgcc cacggccgcc taccggcact tcgccggcca ggcggaactg ctccacgccg
     9241 tgaaggagtt cggccaggag cgcctcgccg accgcatgga ggcgggcggc cgtgccgctt
     9301 ccgacgacgg cgacactccg gaggcggccg aagcgcgcat gcgggcgctc ggacacggct
     9361 atctctcgtt cgcactggcc gaaccgggcc tctaccgcgt cgcgttctgc cgcgatccgc
     9421 tcccgctggg tccgccgcca ggcgtcgccg tccccggagc tggcggggga gagcaggacg
     9481 ccggccccgc ctgggagttc cgctccttcg agatcctcgt ccgcgccctg gacgacctcg
     9541 tcgagcaggg ccgcatgccc gcggagcggc gtacgggagc ggaagtcacc gcctgggcga
     9601 ccgtgcacgg actggcgatg ctctgcctcg acggacctct cgcacaggcc tcgcccgagg
     9661 agatcgacgc cgtcgccgag cgtgccttcg acgtcctcat cgcgggattc accgcgcctt
     9721 cggcgccgcc cgctccgtcc gcgcggcact gagtaccgcg ggtccggcac acgtccggag
     9781 ccgccctcac cgccgcccgg ccacgcgtgc ccgaggccgc tgtgggtgac gtcccgtcgg
     9841 gtgcgcgatc cccgtctccg cccgcctttt cacgccttcc gaagtggccc gtgaggccgc
     9901 cccgccgccg ccgtgccgga gcggcgtgtc cgaaatagga tgttttcgcc cagcggtgta
     9961 gaaacggaga tgtgacggca atggcttctg gcagcacgtg gtgagcgcag aggcggacgc
    10021 gcatgcgcgt gccgtcctcg ccaaggccac gcgggagaac ttcccagtgg cgcccggatt
    10081 cctgccgcgc gaatggcgct acgacctgat ggccgtgtac ggctacgcca ggctcgtcga
    10141 cgacatcggc gacggcgacc tcgcccccgg cggactcgac gcgcagtacc tggggctcgg
    10201 ccccggagag gaaagccggc ccggccccga ccgcctctcg atgctcgacg cactggaggc
    10261 cgatctgctc gccctcttcg acgacgcccg tcccgcgccc ggccacccgc ttctgcgggc
    10321 cctggtgccg acgctgcggc gccgagatct gacgcccgag ccgttcctcg ccctcatcga
    10381 ggccaaccgc caggaccaga aggtccgccg ctacgccgac cacgccgaac tcctcggcta
    10441 ctgcgagctg tccgcgaacc ccgtgggcca cctcgtactg gccatcaccg gcgccgccac
    10501 ccccgagcgc atccggtact ccgacgacgt ctgcaccgcc ctccagatcg tcgagcacct
    10561 ccaggacgtc gccgaggacc tcggccgcga ccgcatctac cttcccgccg aggacatggc
    10621 ccgcttccac gtcaccgagt ccgacctggc cgccccgcgg gccaacgcct cggtccgcgc
    10681 cctgctggcc tacgaagccg accgtgcccg tgccctgctc tcggcgggcg accccctcgt
    10741 ggccagcgtc cgcggccgtc tacggctgct gctcgcgggc ttcaccggcg gtggacgcgc
    10801 aaccctccgc gccatcagcc gcgccggata cgacgtactc ccaggacctc cccgggccac
    10861 cacgcgcggg ctgctgcgcg aggtggccgc aaccctgcga cgagaggggt gagcggaccg
    10921 tggacagagc ccggcccgta ccgtacgtac cgccgccggt ggcagccgcg tacgactact
    10981 gcgagtccgt cacgggccag caggcccgca atttcgccta cggcatccgg ctgctgccga
    11041 gcggcaaacg ccgggcgatg tccgcgctct acgccttctc ccggcgggtc gacgacatcg
    11101 gcgacggtcc tctcccgcgc tcggtgaagg tggcacggct ggaggagacg cgggagctgc
    11161 tcggccgcat ccgcgacggc gggatcgagc aggacgacac cgaccccgtg gccgtcgcgc
    11221 tcgcggacgc cgcgcgccgg taccccgtgc cgatggacgg gctcgacgag ctgatcgacg
    11281 gcgtcctgct ggacgtgcac ggcaccgcct acggcagctg ggaggagctg gaggtctact
    11341 gccggtgcgt ggccggagcc atcggccgtc tctcgctcgg cgtcttcggc accctccccg
    11401 gggtgagcga caccgaccgc gcctccgagt acgccgacac tctcggcctc gcgctccaac
    11461 tcaccaacat tctcagggac cttcgggaag acgccgagca cgggcgcacg tatctgcccg
    11521 cggaggacct ggagaagttc ggctgctccg cggacttccg caacgggcag gcgcagcccg
    11581 gcagcgactt ccgcgggctg atgcatcacg aagtccagcg cgcccgcgcc ctgttcgccc
    11641 gtggataccg gctgctgccg ttgctggacc gcaggtccgg tgcctgtgtc gccgccatgg
    11701 ccgggatcta ccagcgtctg ctggaacgta tcgccgccga tccgtacgcg gtgctgagcg
    11761 agcgcgtgtc cctgccgaac cggcagaagg cgtacgtggc ggtgcgcgga ctcaccggca
    11821 tcgacgcccg gttcgccgcg aggcggagca cgcgcacatg accggaggcg agcgcaccac
    11881 tcactcacgc cgcgacgtcc acggaccccg cggcgccgtc gtggtcggcg gcggcatcgc
    11941 cggaaccacc gcagcgctcc ggctggccga cgccggcgtg ccgaccaccc tcctggagtc
    12001 gcgcccgcgc ctcggcggcc tcgctttctc cttccaccgc gactccccgg cgggaaggct
    12061 caccgtcgac aacggccagc atgtgcacct gcgttgctgc acggcctaca catggttcct
    12121 cgaacggatc ggcggtgcgg ggctcgcacc gctccagcgc cgtctcgacg tgccggtgct
    12181 cgatgtggcc ccggagaggc cccggttggc gaggctgcgc cgcaactcgc tgcccgtacc
    12241 gctgcacttg gcctcggggc tcgcctgcta ccgccacctg acggcggggg agcggagccg
    12301 cgcggcccgt gcggcactcg ccctgcgcgg actcgatccg gccgatcccg ccctggacga
    12361 cgtggacttc gcgacctggc tgcacgggca gggacagagc gaccgcgcga tccgcgcgct
    12421 gtgggacctg gtgggcaccg cgacgctcaa cgcccgtgcc ccgcatgcct cgttgggcct
    12481 cgccgcgaag gtcttcagaa cgggcctgct ctcggagccg ggcggcgccg acatcggcgt
    12541 ctcacgcgta ccgctcgggc atctgcacga caccctcgcc ggcagggcgc tgcgggcggc
    12601 cggggtccgc gtccggaccc aggcccgcgc ccgtgcggtc accgcggcgc ccggcggcgg
    12661 atggaccgta cacgccgagc acggtcaggg gtccgcggcg cagcaccgcg agcaccgtgc
    12721 cgacgccgtc gtgctggccg tgccccagca tgaggcccac gatctgctgc ccgagggtgc
    12781 gctgcccgcg cccggcagac tgctggagat cggcaccgca ccgatcctca acctccatgt
    12841 cgtctacgac cgtcccgtgc tgcgccgccc cttcttcgcc gcgctcggat cgcccgtcca
    12901 gtgggtcttc gaccgtacgg ggcccgccgg gctcggccgg ggccagtacc tcgccgtatc
    12961 gcagtcggcc gcgcagcagg agatcgaccg gccggtcgcg gcgctgcgcg agcgctatct
    13021 cccggaactg gcacgcctgt tgcccgccgc acgcacggct cgcgtgctcg acttcttcgt
    13081 gacccgggag cgcgccgcca ccttcgaccc ccgtcccggc gtcggccggc tgcgccccgc
    13141 ggcccgtacc tcggcgcccg gtgtctgcct cgccggagct tggaccgata ctggctggcc
    13201 cgcgaccatg gagagcgccg tgcggagtgg gacgaccgcc gcccgggagg ccctcaccgc
    13261 cgtgggcagc acgtacgaca atgatccggt gcccggcacc acacgaaagg gcggtggcat
    13321 gagcagcgcc gatcaaggcg gcacgtccgg aggacccaga cggacggcac agcaccaacc
    13381 ccccacacca gcaccgcgag cagccgtacc cccacgagcg gcacccaacg cagaggagac
    13441 cccgtgacca cggcgaacca gcactccgtc gtcgacaacg cgagcgtcag cgctctgctg
    13501 gagcgcgggc gcaggctcgc aactcccttg ctgcgcgccg ccgtcgaccg gctcgcacct
    13561 ccgatggaca ccgtcgccgc gtaccacttc gggtggatcg acgaatccgg ccgcccctcc
    13621 gaggcgcacg gcggcaaggc cgtacggccc gcactcgcgc tgctctcggc cgaggcggcg
    13681 ggcgccgcac cggagacggg cctgcccgga gccgtcgccg tcgagctcgt gcacaacttc
    13741 tcgttgctcc acgacgacct gatggacggc gacgagcagc ggcgccaccg cgacaccgtg
    13801 tggaaggtcc acggcccggc ccaggcgatc ctcgtcggcg acgcgctctt cgccctcgcc
    13861 aacgaaatac tgctggagcc cggcaccccc gaggccggcc gcgcgacccg gcgcctgacg
    13921 cgggccaccc gcaggctcat cgacgggcag gcgcaggaca tctcctacga gcaccgtgaa
    13981 gaggtcacgg tcgaggagtg cctggagatg gagggcaaca agaccggcgc gctgctggcc
    14041 tgtgccgtct ccatcggggc ggtgctcggc ggcgccgacg accgcacggc cgacgccctg
    14101 gagtcctacg gctaccacct gggactcgcc ttccaggccg tcgacgacgt gctgggcatc
    14161 tggggcgacc cggaggccac cggcaaacag gcctggagcg acctgcggca gcgcaagaag
    14221 tcgctgcccg tggtggccgc cctcgcctcg ccggaccccg ccgccacgcg gctcgccgaa
    14281 ctgatgagga ccgacgcgaa gaagagccag gcggagttcg aggacttcga cgaggccgag
    14341 ttcgccacgc gggccgcgct gatcgaggag gccggcggcc gcgagtggac ctcggcggag
    14401 gcacagcggc agcactccac cgcactcgcc gccctcggac cgctcgacat gccgggtcat
    14461 gtgcgcgatc agctgaccgc gctggccgac ttcgtcgtcg tacgacagcg atgaccatct
    14521 gccccggcgt tcgggccgtc gccggagcat ccggaaggga atgagatgac agcgacgacg
    14581 gacaccggca ccggggccac cgcacccgcc accgccacga caccccccac ggacggcgcc
    14641 gagcaagcgc gagaggccgg cagcctggcc gaccgcgccg cgcgtgccgc cgcgctcgcc
    14701 tcggagcatc tgctcgacag acaggacgcg gcgggctggt ggaagggcga cctggagacc
    14761 aacgtcacca tggacgccga ggacctgctg ctgcgcgagt tcctcggcgt ccgcgacgag
    14821 acgaccacgc gcgaggcggc ccgccacgta cgtgcacagc agcgcgacga cggcacctgg
    14881 gccaccttcc acggcgggcc gggggacctc tccaccacga tcgaggcgta cgtcgcgctg
    14941 cggctcgcgg gcgacgaccc ccacgcgccg cacatggagc gggcgtcggc gtgggtgcgc
    15001 gagcagggcg gcgtcgcctc cagccgggtc ttcacgcgga tctggctggc gctcttcggc
    15061 tggtggcgct gggcggacct gccggagatg ccgccggaga tgatctggtt cccgaagtgg
    15121 ttcccgctga acatctacga cttcggctgc tgggcccggc agacgatcgt gccgctgacc
    15181 gtcgtgtgcg cgaagcgccc cgtacgggcg gcgccgttct ccctcgacga gctgcaccgc
    15241 gaccccgggc gccccaatcc gccgcggccc atggcaccgg cggcaagctg ggagggcttc
    15301 ttccagcgcc tggaccgcac gctccacgca taccgccggg tcgcctcgcg ctcgctgcgc
    15361 agggccgcgc tgcgcagcgc cgcccggtgg atcgtcgagc ggcaggagaa cgacggctgc
    15421 tggggcggca tccagccgcc cgccgtctac tcgctgatcg ccctgcggct gctcggctac
    15481 gacctcgatc acccggtgat gcgggcgggg ttggaatccc tggaccggta cacggtgcgg
    15541 tatgagacgg cgggcggtga ggacggtggc cagaaggcgg agggcggcac ggcgcgcatg
    15601 gtcgaggcgt gccagtcccc ggtgtgggac acctgcctgg ccaccatcgc cctcgccgac
    15661 gccgggcttc cggcggacca tcccgcgctc gtcaaggccg cggactggat gctcggcgag
    15721 caggtgctgc ggcccggcga ctggtccgta cgcaagcctc aactgccgcc cggcggctgg
    15781 gcgttcgagt tcgagaacga caactacccg gacgccgacg acaccgcgga ggtcgtgctc
    15841 gcgctgcgcc gcgtacgcca ccacgaccag gcgcgggtcg acaccgccgt gcgcagggcc
    15901 gtgcgctgga gcctgggcat gcagtcacgg agcggcgcgt ggggtgcctt cgacgccgac
    15961 aacgacagcc ccttccccaa ccgcctgccg ttctgcgact tcggcgaagt gatcgacccg
    16021 ccgtcggccg atgtcaccgc gcacatggtg gagatgctcg cggccgaggg ccgcggcgac
    16081 gatccgcggg tgcgcagggc cgtgtcctgg ctgctgtccg aacaggaggt cggcggcgcc
    16141 tggttcggcc gctggggcgt caactacgtc tacggaacgg gctccgtcgt gccggcgctc
    16201 gtcgccgccg ggctgcccgc ctcccatccg gccgtgcgcc gcgccgtcgg ctggctggag
    16261 agcgtgcaga acggcgacgg cggctggggc gaggacctgc gctcctaccg ccccgggcac
    16321 gaacgagagt gggccggacg cggcacctcc accgcctcgc agaccggctg ggcgctgctc
    16381 gccctgctcg ccgcggggga gcgggagtcc atggccgtcg agcagggcgt cagctggctc
    16441 gcacgcacgc agcgggagga cggctcctgg gacgagccgc acttcaccgg caccggcttc
    16501 ccctgggact tctccatcaa ctaccacctc tacaggcagg tcttcccgct caccgcgctc
    16561 ggccggtacc tgtacggcac gggcaccggg ccgcaggaag agagatgacc gactccggcg
    16621 accgcggccc gctgctgatc gcctgcgcgc tgggcatcga gcggctcgcg ctgcggcgcc
    16681 tcggcgtctc cccgtacggg gcggacgcgg cggacggcac cgggggcccg gtcaccgtgc
    16741 tgcgcaccgg catgggtccc cgcgccgcgg aacgcgcggt ggaacgggcg ctgcgggacg
    16801 agcgcgagcc gggcggcacc gcagtggtgg cgacgggatt ctgcgccggg ctcatgcccg
    16861 gactgcaccc cggcgacctc gtcgtcgccg acgagacacg ggacgcagcc ggccgtacgc
    16921 agtgcaccgg cacacagctg cttgccgacg cgctgcgccc gtacggaacc gttcacgtag
    16981 gccccctcgc cggctccgcg cacatcgtgc gcggtcccgc gcgggccgcc ctgcacgccg
    17041 cgaccgccgc cgtcgccgcc gacatggagt ccgccgcgac gctccggacc gccgcacgca
    17101 cgggcccggc ggggcggcag cgccctgttg cggccgtacg ggtggtggtc gacgcccccg
    17161 gacatgaact catccgtccc gggacactgc gaggtggaat atcggcattc cgcgttcttc
    17221 gcggcgttat gcccgcattc ctcgaatggc accgatcctt gctgctcccc tggaggtgag
    17281 cgagtcatgg ccatgcctct gcgccagacc gtccgaatcg gcagctatct cttccagcag
    17341 aagctgcgag gccgcgagaa gttcccgctg atcgtggagt tggagccact gttcgcatgc
    17401 aacctcaagt gcgagggctg cgggaagatc cagcacccgg cgggtgtgct caagcaacgg
    17461 atgccggtag cgcaggcggt gggggccgtt acggagtcgg gggcgccgat ggtgtccatc
    17521 gcgggcgggg agccgctgat gcacccgcag atcggggaga tcgtccgaca gctcgtggcg
    17581 aagcggaagt acgtcttcct ctgcaccaac gccatgctgc tgcgcaagaa gctggacgag
    17641 ttcaccccgt cccggtactt cgccttcgcc gtgcacatcg acgggctgcg ggagcggcac
    17701 gacgagtccg tggcgaagga aggcgtcttc gacgaggccg tcgaggcgat gaaggaggcc
    17761 aagcggcgcg gcttccgcgt caccaccaac tccaccttct tcaacaccga caccccgcag
    17821 accgtcatcg aggtgctcga ctacctcaac gacgagctga aggtggacga gatgatggtc
    17881 tcgcccgcct acgcctacga aaaggccccg gaccaggagc acttcctcgg cgtcgagcag
    17941 acccgcgaac tcttccgcaa ggccttcgcc ggcggcaacc ggcgccgctg gcgcctcaat
    18001 cacagcccgc tcttcctcga cttcctcgag ggcaaggccg acttcccgtg caccgcgtgg
    18061 gccatcccca actactccct cttcggctgg cagcggccct gctacctgat gagcgacggc
    18121 tacgtgccca cgtacaggga gctggtcgag gagaccgact gggaggcgta cggacgcggc
    18181 cgcgacccgc gctgcgccaa ctgcatggcg cactgcggct acgagcccac cgcggtgctg
    18241 gcgacgatga gttcgctcaa ggagtcgctg cgcgcggcac gggacaccgt gcgcgcctga
    18301 gacggccgcc ggacggccgc ggccgccggg ccgtacgcca cgggccgcac atcgcgggcc
    18361 gcagatcacg acgggaatcc gacaccggga agggggccgg gggatgagcg acttcgacct
    18421 caaggagctg ctcgcgcagc gcgcggccga acggtacgag ctgcacgcac gccacctgaa
    18481 ccaccagcag ccgcggatgc tgcgcacgat cggcttcgac aaggtctacg aacgggccga
    18541 aggcgccctc ctgttcgacg ccgacggcaa cgactacctc gacatgctcg ccggcttcgg
    18601 cgtgatgggg atcgggcgtc accaccccgt ggtgcggcag gcgctgcacg acgtgctcga
    18661 agcgcagctc gccgacctca cccgcttcga ctgcccgccg ctgccgggcc tgctcgccga
    18721 gcggctgctc gctctcgcgc cgggaatgga acgggtctac ttcggcaaca gcggtaccga
    18781 agctgtcgag acggcgctga agttcgcccg ctgcgccacc ggccggtccc gggtcctcta
    18841 ctgcgaccac gccttccacg ggctcaccgc cgggtcgctg tccgtcaacg gcgaggcggc
    18901 cttccgccgc ggcttcggcc cgctgctgcc ggacacggcc gtgccgctgg gcgatctggc
    18961 cgctctggaa cgggagttga ggaagggaga ggtcgcggcg ctcatcgtcg agccgatcca
    19021 gggcaagggc gtacacgccg caccccccgg ctatctggcg gcggccggtg aactgctgcg
    19081 ccggcacggc gcgttgctga tcgtggacga ggtgcagacc gggctgggac gcaccgggga
    19141 cttcttcgcc taccagcacg agcccgacgt ccggccggac ctggtgtgcg tggccaaggc
    19201 cctctcgggc ggctacgtgc ccgtcggtgc gacgctcggc aaggagtgga tcttcaagaa
    19261 ggtctactcg tcgatggacc gggtgcaggt ccactcggcg agcttcggtg ccaacgccca
    19321 ggcgatggcc gccggtctgg cgacgctggc cgtgctggag aacgaggacc tcacggcgag
    19381 ggcgcgccgc acgggcgaga acctgcgcga ccggctcgcg gcgctcgtgg gggagtacga
    19441 gatgctgcac gaggtgcgcg ggcgcggact gatgatcggc atcgagttcg gcaagcccaa
    19501 gtcactcggg ctgcgcggcc gttggacgat gctccaggcg gcgcgcaagg gcctcttcgc
    19561 acagatggtg gtcgtgccgc tgctccagcg ccaccgcatc ctcacccagg tctccggcga
    19621 cgagctcgaa gtcatcaagc tcacaccgcc gttggtgatc ggcgaggccg acgccgaccg
    19681 gttcgtccgc gcgttcaagg agatcatgga cgaggcgcac gacggcggcg gactgatgtg
    19741 ggagttcggg cgcaatctga tcaggcacgc cgcggcgaac cgctgagcac gccggccgcg
    19801 cccctgctca gccgtccctc agccgtcctc cagcatcctc tcctgaaggc gctcacgggt
    19861 ggcccggtcc aggcccagcc cctcggtgag ataccgctcg acgccgcccc acgtctcctc
    19921 gatggtggtc atggcggcgg cgaggtaggc ggcacgggcg tcgaagagcg gtgagagcag
    19981 ctccgccacc tcgggagaca cctcgccctt cgcgccccgg tgcatcttgt acctgcgatg
    20041 gggcgagttg gagcgcagat agtcggcctc gatcgcctcc tggtccacgc cgacggccat
    20101 cagcgtcacc gcgaccgaga gacccgcgcg gtccttgccc gccgcgcagt gcatcagcgc
    20161 gggcacgctg tcctccgcga gcgtgtgcag gatccggctg tgctcagcgg tgcggttctt
    20221 gatcatcgag cggtacgagg cgatcatgcg ggccgcgccc tgcccgtccg cgagcacggt
    20281 gcgcagctgg tccagctcgc cgtcgcgcac catcttccag aactccgcgc cgtcggcggg
    20341 gtcggagagc gggatgttga ggttgcgcac gcccggcagc tccacgtccg ggccctccag
    20401 ggcctggtcc gcggagttgc ggaagtcgaa gaccgtgtgc agtcccaggc cgcccaggaa
    20461 ccgggcgtcc tccggggtcg cgtgcgcgag atggccgctc cggaagagca cgccgtgccg
    20521 gaggcgccgc ccgtccgccg tcggcactcc gccgacgtcg cggaagttgc gcaccccggt
    20581 caacgtgggt tcggtggact gctggctcac ggatgctcct cgtctgtgcg acggcgtgct
    20641 gcccgcaccg acgatacgac atggtcaggg tgcggccggt gtgcccgagt gcgcccatca
    20701 cgcacggtct cgcggcgccc gccgtgggtg tccgtccgtt tcgtcactcg tggtgccgtg
    20761 tgtgccgcga gggtcgaatt caggccccat atcggggttg cggcctgaac gccgccgggg
    20821 gcgacgtgag gggcgctccg atgcgcatat gccggtgtca gcgaacggac ccggtcctgc
    20881 atgcatgcgt atgcgctgtt cgtccgtatc ggatcacgcg gtgtgccgga cagggggatt
    20941 ccggttgtga atcggttcat ggggaacgtg gcgcaggccg tccgcgcgcg gggccgtggt
    21001 cttgtgaact cgcctgttcc gtccgcgagt tcgcagctca tcggtgatga atcggtgaac
    21061 tcggtgacgg ccgggccgac ttgagggggc tccggtccgg tgtccgccgc ccccgccgcc
    21121 gggtggcgag caagtggcta agagtaactg aggggctgca caaggcagtt acgctcacct
    21181 cgcgtgaccc tgtgactacg acagcgatct tcactcgtta ggagctggcg aagggtggcg
    21241 aatatgtcat ccgcgtccgt gatgagtggt tgtgcgcatt agcttggccg aggcgctgcc
    21301 agagctgacg tgccctgtgc ccgtgcttcg aagaagccca ccagccgacc ttgcgatcaa
    21361 ccgaggaatc cgatgtctga acccccgaac catgcggtgc atacaggaag gggaagatcc
    21421 ggcccggcac cgacgtcagg gccccacccc gggaacgccc cgcttccggt cgcagctcag
    21481 gggccccgcg actccgccac gcaggccgcc acggcagcgc tcgcagggca cgcggcggcc
    21541 gcggcatccg cagcgccctc ggccaacggt tccaggcgac ggcacggccg cactcccgta
    21601 cgtcagagcc cgggcgacgc ggcgctcagg ctccgcatgg tgcgcctggc cgtcttcccc
    21661 gcgtccgtca tcgccgtcgc gggcgcagcc gtggtcgcgt acgtgatgac cgccgagggc
    21721 agcatccgcg cctcgggggc gcccgcgcgg ggcgacggcg ggctcgtgct ctggatcgtc
    21781 ctcgccgcgg cgctcttact cgtgtgcggc gtcatcgtcg tcgccgcgca ctccgccacc
    21841 gtccaggccc gtcgcgcgct ggagcgccag accgagctgc gccgctccgt ggcacgcggg
    21901 cggtccgaca tccgcgccct gctgagcagc ctcgaacagg gcgcccgccc ccgtccccgc
    21961 ccgctgccgg cgctgcccga acccgacgtg caggcagacg cgttcgagct cctggcccat
    22021 gaactcgccc acgcccagca ctccgcggag accgccgtca ccgaggccgt ggcgctcgta
    22081 cgcagcaact ccagcggcag cgaggagaag gtcgaggtct tcgtcaacct cgcccgtcgc
    22141 ctccagtcgc tcgtacaccg cgagatcgag ctgctcgacg agctggagaa cgaggtcgag
    22201 gatcccgatc tgctcaaggg gctcttccac gtcgaccacc tcgcgacccg aatccggcgg
    22261 cacgcggaga acctcgccgt gctgggcggt gccgtctccc gccgccagtg gagccgcccg
    22321 gtcaccatga ccgaggtgct gcgctcgtcc atcgcggagg tcgagcagta tccgcgggtc
    22381 aagctcgtgc cgccgatcga gggcaccctg cgcggtcacg ccgtggccga cgtgatccac
    22441 ctgctggccg aactcgtcga gaacgcaacg gtgttctccg ctccgcagac ccaagtgctg
    22501 ctccgtgcgc agcatgtgac ggcgggtctg gccatcgagg tcgaggaccg cggcctgggc
    22561 atgcccgccg ccgagcagaa ccgtatgaac gccgtgctct ccgaccccga gcgcatcgac
    22621 gtcggcgagc tgctacagga cggacggatc gggctgttcg tggtctcggc gctcgcccag
    22681 cggcacggca tcgtcgtaca gcttcagagc aacatctacg ggggcatcca ggccgtgctg
    22741 gtgctgccgc gcgaggtcct cggcgacgag cccgcgagcc cggtggagca gtccggcgcg
    22801 gccgtcgcca ccggtacggc cgcggcccgg aacggggcgg cccgcatgcc gcatgcccgt
    22861 acggagagca ccgagcatcc gctgccggcg gccccggagg gagcgcgtca gccgcagccg
    22921 ccactccagc cgcaggcctc gctccactcg caggacccgc ttcagtcgca ggcctcgcag
    22981 gatccgcttc agtcgcagga gggggcgcat ccgcagtccc ggcccctgcc ggagccgcgg
    23041 tcccggtccg aggcgcacgc tcacgcccag tcccagtccc agtcccagct cgggtcgcgg
    23101 gcgcagtccg gggcggacga ctcgacggcc ccgtcgcccg ccgcggcctc gtactccccg
    23161 ccgcggcccg gcgcggagcc ccgcctcccg gggcactcac ggcgccagac gtccgcgccc
    23221 gcttcccagc ccgcaaccgc cgccgtgaac ggcgagcgtc ccgaactgcc gcggcgccgg
    23281 cgccaggagc atctcgcgcc cgagcttcgt gaggcaccgc ccgcgcgggg cggtgagccg
    23341 ggcggcacct cctgggacgc gacgacgcag ggccacgatc ccggcctgat ggccgccttc
    23401 cagcgcggta cgagccgcgc cgaggaatcc gacggcgacg ccgcaggccc cggcccgggt
    23461 cccgacgccg gcgcgagcac aggcatgagc acaggcacga gcaccggcaa cgaagctccc
    23521 caccccgccg actgaggccg ggccggtgcg ttttccgcga tcctccggcc tgcggcacgg
    23581 gcgttcccac ctgcccaccg ttgcggcgga tcagacgtcc ccgagctcgc ggccgtacgc
    23641 attcgccgcg ggcctgattc cgagattccg acggaccggt acgggcacgg cctcgtcccg
    23701 cccgctccgc ggttcccgcc ctgaaggaga agaacgcgat catggtgagc gaagccccca
    23761 tcggccactc ggcagacctg tcgtggctgt tgaccggact cgtacagcgc gtgcctcaca
    23821 cgcgcagtgc gctcctgctg tcctccgacg gtctggtgaa ggccgtgcac ggcctggaga
    23881 ccgacaccgc cgaccacatg gcggccctgg cgtccgggct ctactcgctc gcacgcagcg
    23941 caggcgtgcg cctcggcgac ggcggtgacg tgcgccaggt cgtcgtggag ctcgacacgt
    24001 cgctgctctt cgtctcgacg gcgggccagg gcgcctgcat cgccgtcctg gccgggcggg
    24061 acgccgacgc cgccgtgctc ggatacgaga tggcgatgct cgtcaagagc gtccgcccct
    24121 atctgggcac gcccgcacgc cagccggccg gccactgagg cgccggatga gaagacggca
    24181 gccgtcagag gtgccgttgc tcgacgacga cgcggggcgg ctgatccgcc cgtacaccgt
    24241 cagcaacgga cgtacgaagc cctcggccca gttcgacctg ctgaccatgg tgatggccac
    24301 cggcgaccgc ccgtacagct atctcggacc ggaccacagc catgtgctca agctctgcgg
    24361 cggccccgtc tcggtggccg agatcgccgc gcagatagcc cagcccgcag tggtcaccaa
    24421 ggtgctgctg tccgacctgg tggactgcgg agcgatcact tcgcgtgctc cgggacgtgc
    24481 gccgctgggc aacgacccga ccgatcgaca actgctggag gcggtgctgg atgggctccg
    24541 tagacgactc tgaggcgagc cgtgccgatc cgttccctgc cgcgctgaag atcctcatcg
    24601 ccggcggctt cggcgtcggc aagacgacct tcgtgggcgc ggtgagcgag atcgagccgc
    24661 tcagtacgga ggagctgctg acccaggtca gcgcggccac cgacagcctc gagggcgtcg
    24721 aggacaaggc caccacgacc gtggccatgg acttcgggcg catcacgctc agcgcctcgc
    24781 acatgctcta tctcttcggc acgccgggcc aggagcgctt ctggttcatg tggaacgagc
    24841 tgtccgaggg cgcgctgggc gccgtggtgc tcgccgacac ccggcgcctc gaacactgct
    24901 tcgccgccgt ggacttcttc gaacggcgcg ggatcacctt catcgtcgcg gtgaacgagt
    24961 tcgacaactc ctaccactac gggcccgacg aagtccgcgc ggcgatcgac ctcaaacccg
    25021 atgtgccggt ggtgctctgc gacgcccggg agtccagatc ggccacacag gttctcgtct
    25081 cccttgtcca gcatctgatc aacacgagga gctcccatgg caccgatgtc gtttgacccc
    25141 accagccatc tgctgctgac acccgaggac accgaggcgc ccaacagggt cgtgcggctg
    25201 cgggagttgg gcctcggcga ggcgcccgtc cccgagttcg acgacttcgc acgccatctc
    25261 gcgcgggtca ccggcgcgcc gtacgccatg gtgaacttca tcgacgagga gcgtcagtac
    25321 ttcgcggggc tgtacgcgcc cggctcggac caggcggtcg agctgaaccc gggctcgggg
    25381 gccggcgccg acgcgtccgt cggccgcgtc atggcccgcg atcacggcta ctgcccccat
    25441 gtcatcgtgc ggcgcaaggc gctcgtgctg gaggacgtgt gcgactatcc gcgcttcgcc
    25501 gggaatccgg tggtcgacga gatcggtatc cgctcctacc tcggtgcccc gctgatagac
    25561 cgcacgggca tggccctcgg caccgtgtgc gtggtcgacc aggagcccag gccgtggggg
    25621 cggcaggggc tggagaccat caagtcgatg gccgctgacc tggtggagca gatccaccgg
    25681 cgggagcacc agggaccctg aacggcggcc ggccggccgc gtatcggtga ggtgtccgtg
    25741 gtgctcccgc gtgcttccgc gctgcccgcc ctgcccgcgc tcctcagccc gcgggctccg
    25801 gctccagccg caccagttcg ctcagccgct cggaccagga gcccttggcc gtcccgaggg
    25861 cgacctcccc gagccgaagc cgctggacgt cggaggtgcc ggccggggcg aagatgtggt
    25921 gggcgtcgcg gagatagcgc tcgacgggcc ggtcggtgaa gagcccgcag gccgcgtgga
    25981 tctccatggc gtcccgcgcg gagtccaggg cgtactccac gttcacgagc ttggcgttca
    26041 tcaactccgc gtcgcacggc tgcccttggt cgagcaggtg cacggcgtgg tacgcggcga
    26101 ggcgtgccgt catcaggcgg gactgcatct ggccgagttt cagcttgacg gaaccgagtt
    26161 cgccgagcgg agccccgtag cgccggcgtt cggcgcagaa ggcggatgtc tcgtcgagga
    26221 tcgcctggtg aatgccgagc gagacggccg tgaggttcgc ccgcccgtac aggacgctgg
    26281 aggagtaggc gaccgcgagg ccgtcgccct cctcgccgag ccggttggcg gcgggcacgc
    26341 ggcagccgtc gaagaccagc tcgccgaagc tgaagccgtg caggcccatg gcggggcgct
    26401 ggcggcccag ggagaagccg ggggtgtccg actccacgag gaaggccgtg aggcccttgg
    26461 agccggggcc ggtgcggacc acgacgccgt ggagatctcc gacgtgtgag ttgccgacgt
    26521 agaccttgct gccgttgagg atgtagtcgt cgccgtcccg cacggcggag gacgtcattc
    26581 cgagtacgtg gccgccggac tccggctc
//
