LOCUS       NZ_JAAVIO010000013     25239 bp    DNA     linear   CON 03-AUG-2024
DEFINITION  Bacillus toyonensis strain M5 contig13, whole genome shotgun
            sequence.
ACCESSION   NZ_JAAVIO010000013
VERSION     NZ_JAAVIO010000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus toyonensis
  ORGANISM  Bacillus toyonensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 134530)
  AUTHORS   Huang,Y., Palmer,J.S., Ding,Y. and Yu,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-MAR-2020) School of Food and Advanced Technology,
            Massey University, Private Bag 11222, Palmerston North,
            Manawatu-Wanganui 4442, New Zealand
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012395365.1-RS_2024_08_03
            Annotation Date                   :: 08/03/2024 02:52:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,219
            CDSs (total)                      :: 6,078
            Genes (coding)                    :: 5,835
            CDSs (with protein)               :: 5,835
            Genes (RNA)                       :: 141
            rRNAs                             :: 17, 6, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 10 (5S)
            partial rRNAs                     :: 7, 6, 13 (5S, 16S, 23S)
            tRNAs                             :: 100
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 243
            CDSs (without protein)            :: 243
            Pseudo Genes (ambiguous residues) :: 0 of 243
            Pseudo Genes (frameshifted)       :: 103 of 243
            Pseudo Genes (incomplete)         :: 148 of 243
            Pseudo Genes (internal stop)      :: 73 of 243
            Pseudo Genes (multiple problems)  :: 69 of 243
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:32:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 30530
            Orig. end                         :: 55769
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAAVIO010000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(919..1488)
                     /locus_tag="HB668_RS27060"
                     /old_locus_tag="HB668_27060"
     CDS             complement(919..1488)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782792.1"
                     /locus_tag="HB668_RS27060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27060"
                     /product="hypothetical protein"
                     /protein_id="WP_000782800.1"
                     /transl_table=11
                     /translation="MKMKRKIMMTTALAATLATGALPTTSVFAAEKEAPIQQKEAQVSI
                     QPFAQNNLETAVNAALNGPEVKKIKVFEHEFNVKEIEVVNLGAGKKYVKGQISHHLSFR
                     PDDQFYYEFTVQDGKVIDKPVFNIDRGGWTPFAAPLLSILAAYNGIPVNPNDLNALGQQ
                     LGKVIDGSWEHAAQSIATVVSLSFNE"
     misc_feature    complement(1814..1827)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.21"
                     /tool="antismash"
     gene            2134..2976
                     /locus_tag="HB668_RS27065"
                     /old_locus_tag="HB668_27065"
     CDS             2134..2976
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="HB668_RS27065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27065"
                     /product="metallophosphoesterase"
                     /protein_id="WP_001036669.1"
                     /sec_met_domain="Metallophos_2 (E-value: 3.4e-10, bitscore:
                     33.3, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKTKRIILLIGTIVGICIFLYLQNNLISITEVKITSSKIPSAF
                     KGYKILQISDLHNKKFGDNQDILIQKVKSINPDIIAITGDLIDSKSYDEEISMQVIREL
                     VKEYPVYFVTGNHEKWSGKYNSLEKELKKNHVTVLRNEHVIIQKGGQEINLLGIDDPEF
                     NNRDINEGSIVKDAIVKAKIETQPNRYNVLLSHRPEFIEEYAEERIDLVFSGHAHGGQV
                     RLPFISGLVAPNQGVLPKYTAGLYEEQNTSMVVSRGLGNSIIPQRILNRPEIVVAQLN"
     gene            3192..3443
                     /locus_tag="HB668_RS27070"
                     /old_locus_tag="HB668_27070"
     CDS             3192..3443
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="HB668_RS27070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27070"
                     /product="hypothetical protein"
                     /protein_id="WP_000548627.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCQCLLVSHPEQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDLARIRKYMNLET"
     gene            3630..4355
                     /locus_tag="HB668_RS27075"
                     /old_locus_tag="HB668_27075"
     CDS             3630..4355
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016108448.1"
                     /locus_tag="HB668_RS27075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27075"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_098257576.1"
                     /transl_table=11
                     /translation="MQKPSIVLQNVSKSFGKKEVLHDLSLQIEKAEIFGLVGPSGSGKT
                     TLIKLIAGINQASKGDVFVYNINMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKHKKERIKEVFDLVQLSQHMKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWGKFYELKKKGTTIIVTTHIMDEAEFCERLGLIREGNLVAIGTPEELKK
                     RVSSGRIEDVFLLEEGVES"
     gene            4352..5371
                     /locus_tag="HB668_RS27080"
                     /old_locus_tag="HB668_27080"
     CDS             4352..5371
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="HB668_RS27080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27080"
                     /product="ABC transporter permease"
                     /protein_id="WP_061530235.1"
                     /transl_table=11
                     /translation="MRVNGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYK
                     PHIAVVDVPASIVKVMKNQEASIYEYRKEKAISELEKQKIDAVIHLENGKINLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVVGYIIGFGIFAFIQSVIIVSFSVYVLDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLIIVPQIFFSGLFPIESMNKW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            5396..6049
                     /locus_tag="HB668_RS27085"
                     /old_locus_tag="HB668_27085"
     CDS             5396..6049
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161720.1"
                     /locus_tag="HB668_RS27085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27085"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_000711180.1"
                     /transl_table=11
                     /translation="MKKDWLEELIAATNTDNRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQAFAKEIFKTDYESYEGLL
                     RVVIHNRFEFAKKHFPMIKILIQEVPFQPELKSEIQQLVETELLSHFKKLIVKFQEEGG
                     IIEMPPPSVLRLTLSAVLGFLLTRFLLLPEENWDDELEIENTIQFILYGLTPRR"
     gene            6054..7022
                     /locus_tag="HB668_RS27090"
                     /old_locus_tag="HB668_27090"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="HB668_RS27090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27090"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_061530234.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGIPRETIRIVEENGVNKLVQPSTREDVTEKMEQFSNGFLQTISDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGPGLFGGAVLKNFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKDLVSFQSDNKYLFMAYNQVKQKELGRIIANQKNETIEIVFD
                     NYEKTLYELFLRAPRYTSNVNVCEHIFGYFKTKLKKQEKDYFLELIQKYAEKKIPLSSL
                     LAILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="HB668_RS27095"
                     /old_locus_tag="HB668_27095"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="HB668_RS27095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27095"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397277.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.3e-41, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.5e-27, bitscore:
                     88.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.6e-58, bitscore:
                     189.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKTISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANHAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="HB668_RS27100"
                     /old_locus_tag="HB668_27100"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="HB668_RS27100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27100"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_061530233.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 6.4e-12,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 8.6e-08, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 7.5e-08, bitscore: 25.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.1e-10, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNVEAIHPGYGLLSENPSFPIRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPITEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNIRMDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LENALEELKIEGIKTNTPMLLQVLGDDVFKSGIYTTGFVTKQLVKK"
     misc_feature    8443..8457
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.62"
                     /tool="antismash"
     gene            9764..9979
                     /locus_tag="HB668_RS27105"
                     /old_locus_tag="HB668_27105"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="HB668_RS27105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27105"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="HB668_RS27110"
                     /old_locus_tag="HB668_27110"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="HB668_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27110"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775420.1"
                     /sec_met_domain="HMGL-like (E-value: 3.8e-50, bitscore:
                     163.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALTVIEDITKQAIFEGKKVRGYVSTVFGCPYEGDISATAVDEIC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEHGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLWRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="HB668_RS27115"
                     /old_locus_tag="HB668_27115"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 2.7e-74. Score:
                     241.5. Matches aSDomain:
                     nrpspksdomains_HB668_RS27115_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="HB668_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27115"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_000939820.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLEELQTILTEI
                     SEESDTRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVGMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIASENASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPADLLEEKAIEIANQIASNGPIAVRLAKEAISNGVQV
                     DLHTGLQMEKQAYEGVIHTEDRLEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HB668_RS27115_ECH.1"
                     /evalue="2.70E-74"
                     /label="HB668_RS27115_ECH.1"
                     /locus_tag="HB668_RS27115"
                     /protein_end="254"
                     /protein_start="14"
                     /score="241.5"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLEELQTILTEISEESDTRVVILTGA
                     GEKAFCAGADLKERAGMNEEQVRHAVGMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIASENASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPADLLEEKAIEIANQIASNGPIAVRLAKEAISNGVQVDLHTGLQMEKQAYE
                     GVIHTEDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="HB668_RS27120"
                     /old_locus_tag="HB668_27120"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="HB668_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27120"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000893092.1"
                     /transl_table=11
                     /translation="MLEQKQQSNNFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPSNYLEKTPLMTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRIIDDGSFFEVKKLFAQELITGLARIDGKPIGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIIVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="HB668_RS27125"
                     /old_locus_tag="HB668_27125"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (97-521). E-value: 3.2e-82.
                     Score: 268.2. Matches aSDomain:
                     nrpspksdomains_HB668_RS27125_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="HB668_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27125"
                     /product="AMP-binding protein"
                     /protein_id="WP_000806477.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-88, bitscore:
                     290.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWIADEVTRKQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKQAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHHYDFSWSTLEKEKPFIHAEEMHSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHINVIEAASIGVPDDVKGEVCHCFVVLRDGVIFTAELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PHIQGLQSSKL"
     aSDomain        13590..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HB668_RS27125_AMP-binding.1"
                     /evalue="3.20E-82"
                     /label="HB668_RS27125_AMP-binding.1"
                     /locus_tag="HB668_RS27125"
                     /protein_end="521"
                     /protein_start="97"
                     /score="268.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RKQPALQYEGENGTSKSFTYEELDNWVSRVANGLKQAGIEKGDRV
                     TIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGK
                     IVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHHYDFSWSTLEKEKPFIHAEEMHSDD
                     PLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLL
                     FGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHS
                     LKSLEVFASTGEPWNPDPWMWLFETVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPIS
                     FNASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKW
                     VHGDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HB668_RS27125_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="HB668_RS27125"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HB668_RS27125_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="HB668_RS27125"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15705..15872)
                     /locus_tag="HB668_RS27130"
                     /old_locus_tag="HB668_27130"
     CDS             complement(15705..15872)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358201.1"
                     /locus_tag="HB668_RS27130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27130"
                     /product="hypothetical protein"
                     /protein_id="WP_000358199.1"
                     /transl_table=11
                     /translation="MDKKDLLSQQLDHVSSDALNTPSKAQEQMQETSQKAHNSNKKGNT
                     QSLHVEDLPN"
     gene            16190..16435
                     /locus_tag="HB668_RS31185"
     CDS             16190..16435
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016081561.1"
                     /locus_tag="HB668_RS31185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000237381.1"
                     /transl_table=11
                     /translation="MVIVTLAIVPGESRSEAVTVTVPGPLAARNTAVKLPEALVMTARG
                     TMKAREGLLNEKLTTTPGVGLPFTNTCPEKNKVLFP"
     gene            16451..16690
                     /locus_tag="HB668_RS31595"
     CDS             16451..16690
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254010.1"
                     /locus_tag="HB668_RS31595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_312032721.1"
                     /transl_table=11
                     /translation="MVSLEVKVIDAGPAGRLNPVGPVGPVGPVGPVGPVGPVGPVGPVG
                     PVGPVGPVGPVGPVDPVGPVEPVAPVEPVGPVGN"
     gene            complement(<16708..16764)
                     /locus_tag="HB668_RS31375"
                     /pseudo=""
     CDS             complement(<16708..16764)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="HB668_RS31375"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEFLSFVAHNPGSIGPTL"
     gene            complement(16962..17330)
                     /locus_tag="HB668_RS27140"
                     /old_locus_tag="HB668_27140"
     CDS             complement(16962..17330)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="HB668_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27140"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_061530471.1"
                     /transl_table=11
                     /translation="MGNIPKVSSHQSSPNIPSQQVNPNTQQGNRKKTRRRIITTLAIML
                     PIIFVLQYSLNNQQEMIKEKQITLNTEQQKLSSVKKDGHSLKNDVKALTSSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     gene            17966..18346
                     /locus_tag="HB668_RS27145"
                     /old_locus_tag="HB668_27145"
     CDS             17966..18346
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450238.1"
                     /locus_tag="HB668_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27145"
                     /product="hypothetical protein"
                     /protein_id="WP_000450239.1"
                     /transl_table=11
                     /translation="METSTFLGLFWGWITVIVSGILFVRPSVLRELKKLVVEDRGFGIM
                     YGFLSIFLGLGTVILHNVWAFNWQGFLTVIAWLALLKGIYIIAYPEPSKKTDFELRILS
                     TRIALAIIGALALWMLIVIYIK"
     misc_feature    complement(18390..18403)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     strong, score: 26.74"
                     /tool="antismash"
     misc_feature    18566..18579
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.37"
                     /tool="antismash"
     gene            18738..19199
                     /locus_tag="HB668_RS27150"
                     /old_locus_tag="HB668_27150"
     CDS             18738..19199
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569864.1"
                     /locus_tag="HB668_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27150"
                     /product="hypothetical protein"
                     /protein_id="WP_000569861.1"
                     /transl_table=11
                     /translation="MIEIKSMIYSYKLKRRIAKDLYGSRDELTMLLNEFNNMKSKLKSD
                     KKKNNMLSRLQLMYQNMKLDKQYSLPFALNSRLLERLEDESIQTTEECVSCLHVMLEIN
                     YEKIKHYGSNTSRSFVPLSQSSICLADFVCLTGFVLLGLLGTITFGGIM"
     gene            complement(19772..20011)
                     /locus_tag="HB668_RS27155"
                     /old_locus_tag="HB668_27155"
     CDS             complement(19772..20011)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HB668_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HB668_27155"
                     /product="hypothetical protein"
                     /protein_id="WP_073990633.1"
                     /transl_table=11
                     /translation="MSWNNDCWSSKKQHCCDDWWKSKEKHHCDDDWSSKEKHCNDDWWK
                     SKEKHHCDDDWSSKRNKCRCKCFFICCHCKRKHW"
     gene            20607..20963
                     /locus_tag="HB668_RS27160"
                     /old_locus_tag="HB668_27160"
     CDS             20607..20963
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="HB668_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27160"
                     /product="hypothetical protein"
                     /protein_id="WP_000535569.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEIFEECKKEKHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVASVSCDVVKLAAIPGSVAVIISICKIEAIFPPVTTIT
                     AEFDFNGVDVANKA"
     gene            21067..21606
                     /locus_tag="HB668_RS27165"
                     /old_locus_tag="HB668_27165"
     CDS             21067..21606
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002065535.1"
                     /locus_tag="HB668_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27165"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_073990635.1"
                     /transl_table=11
                     /translation="MMYERRMRVIKLVPFKRSDFKQLINWIHSEQFLIQWSGNAFTYPL
                     NEQQLEKYIESANTLAFKVIDEKTEEVLGHISLGQIDDINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFEELKLHRVTLGVYDFNTSAISCYEKIGFVKEGLLRDSKKVGETYW
                     NLWEMSMLEYEWNNKK"
     gene            21657..22217
                     /locus_tag="HB668_RS27170"
                     /old_locus_tag="HB668_27170"
     CDS             21657..22217
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002176841.1"
                     /locus_tag="HB668_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27170"
                     /product="hypothetical protein"
                     /protein_id="WP_168388024.1"
                     /transl_table=11
                     /translation="MNRKTIVITIAAVSGGGKTTITESLTHELTNSKALFFDSYNFDNC
                     PADICKWIDDGANYDEWVLTPLIHDIQHLIRDSKLDYIIVDYPFAYLNREMGQFIDVTI
                     FIDTPLDIAMARRILRDFKEDTMSEIHNDLKHYMAHARKVYLEAIHTVKPNSDIVLDGS
                     FSVSEIIDHVVEELDRREVIVNG"
     gene            22210..22950
                     /locus_tag="HB668_RS27175"
                     /old_locus_tag="HB668_27175"
     CDS             22210..22950
                     /NRPS_PKS="Domain: Abhydrolase_1 (27-131). E-value:
                     1.1e-12. Score: 40.1. Matches aSDomain:
                     nrpspksdomains_HB668_RS27175_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237666.1"
                     /locus_tag="HB668_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27175"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_000237661.1"
                     /sec_met_domain="PF00561 (E-value: 2.8e-09, bitscore: 30.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.4e-08, bitscore:
                     27.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKCIEEYVQVDDFKMYTKVFQGKKRQPVIIMESGYGDYSKAWDY
                     IAERLTEFGTILTYDRAGLGKSGKSFKQRISSEMVKDLRTCLNLLQLKPPYIFVGHSFG
                     GINARLFTVFYPEDMLGTVLVDSTPENYKEVFLPIMSPEFQEAYYKQFAYESSYEEFMF
                     SLGEADRHCKSMNDIPLVVLAAGKKAFYSQAAQLKWLQLQRELLQLSSKSKFIIAEHSG
                     HYIQKDEPHYIIGAVKWILGVGER"
     aSDomain        22291..22602
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HB668_RS27175_Abhydrolase_1.1"
                     /evalue="1.10E-12"
                     /label="HB668_RS27175_Abhydrolase_1.1"
                     /locus_tag="HB668_RS27175"
                     /protein_end="131"
                     /protein_start="27"
                     /score="40.1"
                     /tool="antismash"
                     /translation="PVIIMESGYGDYSKAWDYIAERLTEFGTILTYDRAGLGKSGKSFK
                     QRISSEMVKDLRTCLNLLQLKPPYIFVGHSFGGINARLFTVFYPEDMLGTVLVDSTPEN
                     "
     CDS_motif       22492..22527
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HB668_RS27175_0001"
                     /evalue="6.50E-05"
                     /label="NRPS-te1"
                     /locus_tag="HB668_RS27175"
                     /protein_end="106"
                     /protein_start="94"
                     /score="15.5"
                     /tool="antismash"
                     /translation="PYIFVGHSFGGI"
     gene            22953..23411
                     /locus_tag="HB668_RS27180"
                     /old_locus_tag="HB668_27180"
     CDS             22953..23411
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="HB668_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27180"
                     /product="DinB family protein"
                     /protein_id="WP_000288861.1"
                     /transl_table=11
                     /translation="MYTVFQYNWQVREDWFKWCEQLTVEELLRKRVGGVGSILETLFHI
                     VDVEYSWICDLKGKEVDEPQFKDYQSIQKVKALSHLYNKDLEGFLQSWTEDLENKILKV
                     SWTDKEYKYGEVLRHVVVHEIHHIGQLSIWARELNLQPVSANLIGRGL"
     gene            complement(23470..24486)
                     /locus_tag="HB668_RS27185"
                     /old_locus_tag="HB668_27185"
     CDS             complement(23470..24486)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="HB668_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_27185"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_001160069.1"
                     /transl_table=11
                     /translation="MQFLKKFTILLLSFIITALIVLYFYLYVNGPIIQAKSAILIDANS
                     GEVIYKKNEETPIQSATLSKLMTEYIVLEQLNDGKIQLDESVKISNELFQAETTPMQVT
                     AKDKTTVRDLLHALLLTGNNRSALALAEHIGGNEDNFTTLMNEKAKQLQLSQPSPFLNS
                     TGANQDTNKQSNTTAKDAAKLATHLVKDFPNVLNMTKLTSYQFTFKNFQVFNTNKMIYS
                     LNENIKFQGVDGLQTSFSTNGNNSFVGTAKLGDTRLISVILESDEENTTFIETKKLLQY
                     GFEPSSYSALQAFKDTLTSWAILLQFKNLIIQTMMIFFIITILMFLHLRQRKSEDFN"
ORIGIN
        1 tttaaaaata tctcctcaaa tgatagtgat ccactttcag gagtagtttc ttcttttaag
       61 cgcattaaaa ttgtttctgt cggataatct tttaaaaatt gaattgcctc ttttaataca
      121 tcttcaaaca ttgctttttg atttacaatc ccatggtaca ttgcaaaaga atcttttaca
      181 cgtttaacac gcatatctac atatcgaatt ccagaattta attgttgagg tagactcata
      241 gtttgatttc ttgtcaaatt ttcatcaaga aaacttgctc catgtaaagc cattgtaccg
      301 tgagtccctg gaatagatat tttacttagt tttgttgaat cttctacttt cgacatccac
      361 gatggatttt gatatcctat attggattca taggaataac ctggatgact atcagctaaa
      421 ataggagatg gtgtacttaa acttgctagt gtaaaacatg tgaggatgct aattttaaag
      481 aaatttatta tttttatttt gttcatttta tctctcctga cctttaaaca atagattaag
      541 atgattttgt actatattta ttgttttcat tttaaagtaa tgaaattttg tgtttgaaaa
      601 taattaaaaa cagggggagt aacttatttg agactttaat aatttgttgt tatgaattgt
      661 acttaataac caaacggatt cttaaagaat cgaagtatag attcgaaaaa acaacctttt
      721 atcgtattgt atacaaacaa aacagaagcc ttaaaaaaga cttctattct gtgacatata
      781 atgaatgata aggtggttaa caaatcaaga taatgtgact gagtggtaaa aatctattta
      841 tagctgtttc agaatctctt ataacaaggt tacctacgaa aaatgggcct ctgcaaggct
      901 aataaaaatt aaaaagttct actcattaaa acttaaacta actacagttg cgatagattg
      961 ggctgcatgt tcccagcttc catctataac ttttccaagc tgctgaccaa gtgcatttaa
     1021 atcatttggg ttaactggaa tcccattata ggcagcaaga attgataaaa gtggagcagc
     1081 aaatggtgtc caaccacctc tatcaatatt aaatacaggc ttatctatta cctttccatc
     1141 ttgcactgta aactcataat aaaattgatc atctggacga aaacttaaat gatgagaaat
     1201 ttgtccctta acatattttt ttccagcacc tagatttact acttctattt cttttacatt
     1261 aaattcatgc tcaaatactt ttattttttt gacttctggg ccatttaagg cagcattaac
     1321 ggctgtttcc aaattatttt gtgcaaatgg ttgaatactc acttgtgcct ctttttgttg
     1381 gataggagcc tctttttcag cagcaaacac cgatgtagtt ggtagtgcac ctgtagctaa
     1441 tgtagccgca agtgctgttg tcatcatgat ttttcttttc atcttcatag ttttccttcc
     1501 tctcttaaag ttatgatata taatctttta aagactgaca cggtgcaata tattatttca
     1561 taatgcacgc aaaaaatagt ttaagaatta tgtgaaacta tgtcagaaaa ttaaagttaa
     1621 ttatatattc atttacaatg atatctatct acatgcattt tttcaatttt ctaataaata
     1681 atataataat aacttttcat aagggaattt aatgttttaa ttctctctat atacgcttta
     1741 aacaaattaa aatcgtagtg gtaataatat atttgcaagc aaatgtcata tatacttcga
     1801 gaaaaataca caattttttt ataaaaaact ttaggaatta tcattatatc gttattaact
     1861 aaataagata aatgataata tgatgaagag cttccaggga ttcgctataa attcactaga
     1921 gaatgagcat gatatcatac actcatgcag gacgcctagg atattaaagc tccactttat
     1981 agaggagatt ggaaacagca gtaagtgttt attagagacg tataacacta tgaaaaatac
     2041 ttcaaattaa ttggaaagtt tcagtttttt gaattcaaag ggcacggaat gtttattaga
     2101 attgtagttc tgattaagat tttaggagga aaaatgaaca agaagactaa aagaatcata
     2161 ttacttatcg gtacaatagt aggtatttgt atctttttat atttacagaa caatttaata
     2221 agtataactg aggttaaaat aacctctagt aaaattccct ccgcttttaa agggtataaa
     2281 attctacaaa tttcagattt acataataaa aaatttggtg ataatcaaga cattttaatt
     2341 caaaaagtaa aaagcataaa tccagatatt attgctatta ctggtgattt aatagacagt
     2401 aaatcgtacg atgaagaaat tagtatgcaa gtaatacgag aacttgtaaa ggagtatccg
     2461 gtatattttg taacaggaaa ccatgaaaaa tggtcaggaa aatataacag tttagaaaaa
     2521 gaattaaaga aaaaccatgt tactgttttg agaaatgaac atgtaataat acaaaaaggc
     2581 ggacaagaaa taaacttgtt aggtattgat gatccggaat ttaataacag agatattaat
     2641 gaaggaagta ttgtaaaaga tgcaattgta aaagcgaaaa ttgaaacgca accaaataga
     2701 tataatgtat tattatccca taggccagaa tttattgagg agtatgcaga ggagcgaata
     2761 gatttagttt tctcagggca tgctcatggt gggcaagtta ggttaccatt tatcagcgga
     2821 ttagttgctc caaatcaagg tgttttacct aaatatacag caggtttata tgaagaacaa
     2881 aatacatcaa tggtggttag tagaggatta ggcaatagta tcattccgca aagaattttg
     2941 aataggccag aaattgtagt cgcccagtta aattaaattg ggcgactttt tatgtacaga
     3001 atgagtaaag gggctttatg tattttgcag gagttaacat tacaattttg ttaaaaattt
     3061 tctacgttac ataaagtaac aaaatttgac ctgaagagtt tgttatagtg taaataatca
     3121 aaaaacttaa aaattagtcg agtgaaaagt gtgataagga atttatgtaa aaaacttaaa
     3181 ggggtgtaca catgcataaa gaatatgaaa ttgaagagta tacggcgatt gaggaacaaa
     3241 tacattatta ttgtcaatgt ttattagtga gccatcctga gcaaattata aaatatttag
     3301 aaaaaagatt agaaaaatat gcagaaacat tacaatatgc acatttatat cccgatacag
     3361 ttattttacc gttacagcaa ttagttatcg aatattcttt agaccttgct agaattagga
     3421 agtatatgaa tttagaaaca taaagtaaaa tgcatagttt aaatgaaaca gagtcgactt
     3481 taagaaatta tattctaatg tcgattctgt ttcattgttt aatattgttg attgaaaata
     3541 aatactaatc aatgaagttt gacatataat tacgcaagag taaaataaaa gtgagtactc
     3601 actcatttta tagaaaagag ggataataca tgcaaaaacc ttcaattgtt ttacagaatg
     3661 tatcgaaaag ttttggaaaa aaagaagttt tacacgatct ttcattacaa attgaaaaag
     3721 cagagatatt tggtttagtt gggccttcag gatcagggaa aacgacgctt attaaattga
     3781 ttgcaggtat taatcaggca tctaaaggtg atgtatttgt atacaacatt aacatgccaa
     3841 atttaaatga gatgaaaaga attggctata tggctcaagc tgatgcatta tacgaagaac
     3901 tatcagcata tgaaaatgca gattttattg caacgatgta tggattaaag ggaaagcata
     3961 aaaaggaaag aatcaaagag gtttttgacc tggtacaatt atcacaacat atgaaaaagc
     4021 aagtacagca tttttcaggt gggatgaaaa agcgtctatc attagcaata gcacttcttc
     4081 atgaacctga aatattaatt ttagatgagc caacagtggg gatagatccg cttcttagaa
     4141 aaacaatctg gggaaaattt tatgaactta aaaagaaagg cacaactatt attgtaacga
     4201 cgcacattat ggatgaagca gagttttgtg agcgtctagg gttgattaga gaagggaact
     4261 tagttgcgat tggaacgcca gaggaattga aaaaacgtgt atcatcagga cgaattgaag
     4321 atgtcttttt gttagaagag ggggttgaat cgtgagagtt aatggtgtaa tcattcgtat
     4381 tattcgtcaa ttttttcgag ataaacgttc gttagccatg atgtttgggg caccaatgtt
     4441 attactttgg ctattgtctt tagtatttac acaaaaagat tataaaccac atattgctgt
     4501 agttgatgtg cccgcttcta tagtaaaagt gatgaaaaat caagaagcct caatttatga
     4561 atataggaaa gagaaagcga tttctgagtt ggaaaaacaa aagatcgatg cagtaattca
     4621 tttagagaat ggaaaaataa atcttttgtt agaaggcagt gattcgtcga aaaaccgtgc
     4681 tgtactccaa gtattgcaaa agagcacaga gaagaatgat gtatcgatta tgaaacctga
     4741 agtgaattat ttacatggct ctaaagactt tacgatgttt gatgggctcg gtcccgtgtt
     4801 aattggattc tttacatttt tctttgtatt cattttgtca ggagtttctt tcgtaagaga
     4861 acgtttaagt ggtacattag agcgattatt gtccacacca gttagacgat gggaaatagt
     4921 tgttggatat ataattggtt ttggaatttt tgcattcata caatctgtta taattgtaag
     4981 tttttcagtc tatgttttag atttatatgt agcaggttct atatggctaa cgctacttat
     5041 tacatgtatg ctctctttaa cggcactaac attagggacg tttttatcag catacgcaaa
     5101 taatgaattt caaatgatcc agtttatacc gctaattatt gtgccacaaa tcttcttttc
     5161 tggcttgttt ccaattgaat ctatgaataa gtggctacaa atgttaggga aattatttcc
     5221 actcacatac ggtgctgatg caatgaggca agtgatgatt cgaaatcaag gatttacaga
     5281 aattgcattg gatcttactg tattactact tttttcacta ttatttgcag tagggaatgt
     5341 atttgcttta aagaaacatc gcaaaatata ataatgacaa aaaggagctt tgtacatgaa
     5401 gaaggattgg cttgaggaat tgattgctgc aactaatact gataatcgaa atgaacgtca
     5461 aatgcgtatt ttagaagcag ctgttgatat gtttggagaa aaaggatatg cttcaacttc
     5521 aacaagtgaa attgcaaagc gtgctggtgt agcggaagga acgattttcc gctactataa
     5581 gacgaaaaaa gatttattgt tagcggtcgt aatgccaact ttaacaaagt ttgctgcacc
     5641 atttttcgta caagcttttg cgaaagagat atttaaaact gattatgaat cgtatgaagg
     5701 gcttttaagg gtagtcattc ataatcgatt tgaatttgcc aaaaagcact ttccaatgat
     5761 taaaatatta attcaagaag tgccgtttca gccagagcta aaaagtgaaa tacaacaatt
     5821 agtagaaaca gaactgcttt cacattttaa aaagttaatt gtaaagtttc aagaagaagg
     5881 gggaattatt gagatgccac caccttccgt gttacggctt acattatcag ctgttttagg
     5941 atttctatta actcggtttt tattattacc tgaagagaat tgggatgatg aattggaaat
     6001 tgaaaatacg attcaattta ttttgtacgg actaacgcca cggaggtaat gaaatgcgac
     6061 aatttgcaaa acctacaatc gtcgtaagta aatgtttaga atttgatgct tgtcgttata
     6121 atggagaaat gattccggat gtaacaatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag attggattgg gaattcctcg tgaaacgata cgaatcgtag
     6241 aagaaaatgg tgtgaataaa cttgtgcaac cgtcgacaag agaagacgtt actgaaaaaa
     6301 tggagcaatt ttcaaatgga tttttacaaa cgatatccga tgtggatgga tttattttaa
     6361 agaatcgctc gccaagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 cgccagcaaa aggaaaggga ccaggcttat ttggcggagc agtattaaaa aatttttcgc
     6481 accttccaat tgaagaagaa ggtagattgt cgaattttat tattagagaa catttcttta
     6541 caaggttatt tacaatcgca tattacaaaa tgattaaaca taataaaaat atgaaagacc
     6601 ttgtatcgtt tcagtcggac aataaatatt tatttatggc atataatcag gtaaaacaaa
     6661 aagaattagg gcgtattatt gcaaatcaaa aaaatgaaac gattgaaatt gtatttgata
     6721 attatgagaa gactttatat gaattatttt tgcgcgcgcc ccgctataca tcgaatgtaa
     6781 atgtatgtga acatattttc ggatatttta aaacgaaatt aaaaaaacaa gaaaaagatt
     6841 attttttaga actgatacaa aagtatgcag aaaagaaaat accacttagt agtttgcttg
     6901 caattttaaa atcatgggcc attcggtttg atgaaaagta tttattaaga caaacatatt
     6961 ttgagccata tcctgaagcg ttagtagaaa tttctgattc gggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacatgaaa cttcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattagtac agaatctgtt ttaaaattaa gttatgacag aattgtagca
     7141 attgtctaac taatattctt gtcttttaag aagtaatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtgtatta tgacaaaact gcagagtttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattatt aggcatccca ttcccagaag agtatggagg ttcaggtggc gatacagtat
     7441 cgtacgcgct agcagttgaa gaaattggtc gtgcttgtgg tggtacaggc ttaagctacg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 aaaaatattt agttccaatg gcatcaggta aaacgttagg cgctttcgga ttaacggagc
     7621 caaacgctgg atcagatgca ggaggcacac aaacgaaagc tgtattagat ggtgatgagt
     7681 atgtaatcag tggtgaaaag tgctggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctat caacggtgtt gaagagaatg gtagaaaacg tatttctgca tttatcgtac
     7801 cgactacaag tgaaggatta acgatctcaa gtccttacga taagatgggt gttcgcgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tgcgtgtacc gaaagaaaat attcttggtg
     7921 atgttaataa aggatttaaa caattcttat atacacttga tggaggacgt atttcaattg
     7981 cagcattagc agtaggtatt gcacaatctg catttgaacg tgcattgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaaa acaatttcta atttccaagc gattcaattt aaattagcgg
     8101 atatggcgac tgaagtagag ttagcacgta atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggt aaagaagcgg ctatggcaaa actatttgca tctgaagcag
     8221 ctagtcgtat tgcgaatcat gcagtacaaa ttcatggtgg ttatggctat atgcgtgaat
     8281 atgaagttga aagacatatt cgtgatgcaa aactgttaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gctagacatt taggatgtag ataaaaagga ggaatcacta
     8401 tgtttcaaaa aatattaatt gccaatcgcg gggaaatcgc agttcgcatt atgaaaactt
     8461 gtcaaaaact tggaattcgt actgtcgcta tttattctga ggctgatgaa aatgcccttc
     8521 atgtaaaaat ggcaaatgaa gcttatctag taggtggtcc acgagttcaa gaaagctatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgttgaagca atccatccgg
     8641 ggtacggatt attatcagag aatccatctt ttccgattcg ctgtaaagaa gaaggaatcg
     8701 tatttattgg tccttcagaa gaaatcatta cgaagatggg aagtaaaatt gagtcacgta
     8761 tagcaatgca agcagcagat gtaccagtag ttccaggtat tactacaaat attgaaactg
     8821 ctgaagaggc aattgaaatt gcaaaacaaa ttggttatcc attaatgctt aaggcatccg
     8881 cgggtggcgg aggcattgga atgcagttga tggaaactga gcaaacgctc accaaagcat
     8941 ttgaaagtaa caaaacaagg gcacaaaatt tcttcggtaa tggagaaatg tatttagagc
     9001 gttatattgc agacgcgcat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cagtgtactt atgggaacgt gaatgttctg tacagcgccg aaatcaaaaa gtaatcgaag
     9121 aagcaccttc acctttttta gatgaaggta cacgaaaagc aatgggagaa gtggctgtac
     9181 aagctgctaa agctcttggg tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 agaaaaattt ctatttctta gaaatgaata cgagattaca agtagagcat cccattacag
     9301 aagaaattac ggggttagat cttgtagaac aacaacttct tatcgcaagt ggagagaaac
     9361 tatcatttac tcaggatgat gtaaaacgta gtggtcatgc cattgaagca cgtatttatg
     9421 cagaagatcc gaaaacattc ttcccgtcac ctgggaaaat tacagattta acattaccat
     9481 caaatatacg tatggatcac tttttagaga atcatgtaac aattacaccg ttttatgatc
     9541 caatgattgc gaaagtcatt gctcatggtg aaactcgtga agaggcaatt tcaaaattag
     9601 aaaatgcttt agaagagtta aaaattgaag gtattaaaac aaatacaccg atgctactgc
     9661 aagtgctcgg agacgatgtg ttcaaaagtg gtatttatac aacgggtttc gtaacgaaac
     9721 agcttgttaa aaaataagat ttatgaatat taagggggaa aaaatgatga cgaaagtata
     9781 tgcatcgatg gcaggaaatg tttggaagat agttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatca tttcggaaga
     9901 agctggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gaaatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtagggc cacgtgatgg cttacagaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagcc ggattgtcgt acgttgaagt
    10141 ttcctcattc gttcacccaa aatgggttcc tgccttagcg gatgcaaatg atgtcttttc
    10201 tgagctaaaa agggatccca atgttacata tgctgcgctt gttccaaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag cgagtgaatc
    10321 tcataataaa agtaatatta ataaatcaat taaagaagca ttaactgtta ttgaagatat
    10381 aacaaaacag gcaatattcg aagggaaaaa ggttagaggt tatgtttcta ctgtatttgg
    10441 atgtccgtat gagggagata taagtgccac agcagttgat gaaatatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctctcgg tgacacgatt ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaaatatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggga tggcacttgc aaatgtagtg aagtctttag aacacggtat
    10681 tacaacgttt gatagttctt gtggtggact cgggggatgt ccatatgcac cgggagcatc
    10741 aggaaatgtt gcaactgatg atttagtgca tatgctccat aagttaggtg tccaaacaaa
    10801 tatagacgaa gaaaagttat ggagagctag tcaatttatt caaagtaagt taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaatatttca gttgactatg taacaccgca tgttgtaaag atttcgttat
    10981 atcgtgaaag acaagcaaat tctttatctt tagcgttatt agaagaattg caaacaatat
    11041 taacggaaat aagtgaagag tcagatacac gtgtagttat tttaacaggg gctggtgaaa
    11101 aagcgttttg tgctggcgca gatttaaaag aacgagctgg tatgaatgaa gagcaagttc
    11161 gccatgcggt tggtatgatt cgtactacta tggaaatggt ggaacaatta ccacaaccag
    11221 ttattgcagc tattaatgga attgctcttg gtggtggtac ggaattgagt ttagcctgtg
    11281 actttagaat cgcttctgaa aatgcaagcc ttggtctgac tgaaactacc cttgcaatta
    11341 tacctggagc aggtggtacg cagcgtttac cgagattaat tggtgttggt agagcgaaag
    11401 aattaattta tacaggaaga cgtatttcgg cgcaagaagc gaaagaatat ggtttagtag
    11461 aattcgtcgt accggctgat ttactagaag agaaagcgat tgaaattgca aatcaaattg
    11521 ctagtaatgg tcctattgca gttcgattag caaaagaagc aatttctaat ggtgttcaag
    11581 tagatttaca taccggatta caaatggaaa aacaggcgta cgagggtgta atccatacgg
    11641 aagatagatt agaaggatta caggcattta aggaaaaacg caaaccgatg tataaggggg
    11701 agtaaatgtg ttagaacaaa aacaacaatc aaataatttt gaagaacgag ttgaaacgat
    11761 taaacaaggt ggagcaccga aatatcatga acaaaacaaa gcaaaaggaa aactatttgt
    11821 tcgagatcgt ttagctcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 aaattgtgag caaacagggt taccggctga tggtgttgta actgcaactg gtaaaataca
    11941 tgggcgtact gcgtgcgtaa tggcaaatga ttcaactgtg aaagccggat catggggagc
    12001 tcgtacagtt gaaaagattt tacgtatcca agaaacggct gaaaagttac gtgttccatt
    12061 attttattta gttgactctg ctggagcgcg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgcggt gcgggaagaa tcttttataa ccaagtgaaa ttatcaggta aagttccgca
    12181 aatttgttta ttatttggtc cttctgctgc tggtggtgca tatattccag ctttttgtga
    12241 cgttgttatg atggtggaag gtaatgcatc tatgtattta ggatctccac gtatggctga
    12301 aatggttatc ggtgagaagg taactttaga agaaatgggc ggggctcgta tgcattgctc
    12361 agtatcagga tgcggagacg ttttatgtaa gacagaagaa gatgcaatta cacaggctag
    12421 acaatacatt tcatattttc caagcaacta cttagaaaaa actccattga tgacacctca
    12481 agaaccgaaa cagttcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctga ttaacagaat tatagatgac ggctcattct ttgaagtgaa
    12601 aaaattattt gctcaagaac tcattacagg tttagcacgc attgatggta agccaatagg
    12661 tattattgca aatcagccgc gtatgaaagg tggcgtttta ttccacgatt cagctgataa
    12721 agcagcgaag tttattaatt tatgcgatgc ataccatatt ccattattat tccttgcaga
    12781 tgtaccagga tttatgattg gtacgaaagt agagcgcgct ggtattattc gtcacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaaa atttctatca ttgttcgaaa
    12901 agcatatggt gctggtttat atgcaatggc aggtccggca tttgaaccag attgctgctt
    12961 agcattaccg acagcttcta ttgctgtaat gggtccagaa gcagcggtca atgctgtata
    13021 tgcaaataaa attgcggctt taccagaaga agagcgtgca agcttcattg ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatattta tcatttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaaggg cgtttcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gtcaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtataaggaa aaaacacgtt tatatggttg gatgaaatca ttgggatatg
    13381 aagactatga aactttttat aataaatcta ttgaggaaac agcttggttt tggggagagg
    13441 cagaaaaagc agttggctat caatggatga aaccttatac agaagtgtta gatttagaaa
    13501 atggtacgcc atttgcacag tggtataatg gtggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gattgcggat gaagtgacaa gaaaacagcc agcacttcag tacgaagggg
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga caattgggta agccgtgttg
    13681 ccaatggttt gaaacaagcg ggtattgaga agggcgatcg tgtaacaatt tatatgccga
    13741 tgattccgga aacagttgtt gcgatgctag ctgtaatgaa aatcggagca attatttcac
    13801 caatattttc gggatttgct tcggatgcag ttatgacacg cgtacaagca gctggttcaa
    13861 aaatgattat taccgcagat ggattttcac gccgcgggaa aattgtttct ttaaaggatg
    13921 aagtagataa agcttgtgaa cattgcccga ctgttgaaaa ggtggtaatt gttcgtcatg
    13981 caggaaatga ttttacaccg catcattatg acttttcatg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgaa gaaatgcata gtgatgatcc tttaatgctc atatatacat
    14101 caggaacgac tggtaagccg aaaggaacgg tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ctggatgatg gggccatttt tattattcgg ttcactcata aatggtgcaa
    14281 cgatggttat gtacgaaggt gttccagact ttccagaagc agatcgctta tgggagacag
    14341 ttgataaata tgaaattact catctcggta tttcgccaac gttaatccgt gcattaatgg
    14401 caaaaggtga tgagtatgtg aataaacatt ctttaaagag tttagaagta ttcgcatcaa
    14461 caggagagcc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggaaaaggaa
    14521 aagtgccaat ctgtaactat tcaggcggaa ctgaaatttc tggtgggatt ttcggtaatg
    14581 ttctgattaa gccaatcgca ccaattagtt ttaacgcatc gttaccaggt atggctgcgg
    14641 ttgtacttga tgatcaaggt aaaccaatcc gtgatgaagt tggagaatta tgtttagaga
    14701 aaccttgggt tggaatgacg aaaagtttct gggaagacga tgagcgttat gtgaacacat
    14761 attggtcacg atttgaaaat aaatgggttc atggtgactg ggttatttat gatggtgaac
    14821 aatatatcat tacagggcgt tcagatgata cgctaaatat tgctggtaaa cgtattgggc
    14881 ctgctgaata tgagtctatt cttgtgaaac atattaatgt aatagaagca gcttccattg
    14941 gtgtacctga cgatgtaaaa ggtgaggttt gtcattgctt tgtagtatta cgagatggtg
    15001 taatatttac agcagaatta aagaaagaat taatgagttt agtaaattct catatcggaa
    15061 aagcattatg tccaaaggat atccacgttg tagaggattt gccaaaaaca cgtaattcta
    15121 aagtaatgcg acgcgtcatc aaagcggctt acttaggaaa agaattagga gatttatcat
    15181 cacttgtaaa tccagaagta gttccacata ttcagggtct acagtctagt aaattataaa
    15241 tgtaggaatg agctctatgt aaatggagct catttttcat gtttataaaa agagaagaag
    15301 taaatttgaa gtagtaaaat tctacttgta ttattacgac gtatgtttgt tttatagttt
    15361 ttatcaaaat aggattgtgg catgtctatt cattggagtg attgaattgt gttaaggatg
    15421 aaaatttagt gaagcgaaaa gtaatgaata aaaggagaaa tccctggggg acagggattc
    15481 actaagggag aaagtattgt cgtgcaatgt cgaaatttgg catattcgac aaattaatat
    15541 tatcacgaat tttcaggaga ttgtgatagg gaatgtgtca aaaatgtgta cgtatttcct
    15601 attaaagtgt tatgtaaata ggaaaaggga aaaaattaag ttcactcgtt cttaagaatt
    15661 tttcccctta aaatttagta tttgttcgtt attctatata cgtcttaatt tggtaaatct
    15721 tcaacatgta aagattgagt attgcccttt ttgtttgaat tatgtgcctt ctgagatgtt
    15781 tcttgcattt gctcttgggc tttactagga gtattcagcg catcagatga tacatgatca
    15841 agttgttgac ttaataaatc ttttttatcc atgttatgta gctccttttt gaactttgat
    15901 ataaaaacga agtgttttta aatagttacg tgggtattat gtatctttga atggaattat
    15961 atacacaaac tacattgaga agttaactac ttataaaaat tacctgtgat gacaagctga
    16021 agaaatataa agatcattag tgattaataa aagcattatt ttagtagggt gttacgaaat
    16081 ttcatttaaa aagaacatcc caatgataaa aaagagcact gtaaatcagt gctcatctta
    16141 tcagaaactg cttagtcctt aaaaacaaaa ccattacgga caattcacaa tggtaatagt
    16201 gacgctagcc attgttccag gagaatcaag aagtgaagca gtaacggtta ctgttccagg
    16261 cccattagcg gctagaaata cagcggtaaa gttacctgaa gcattggtaa tgacagcaag
    16321 aggaaccatg aaagcaagag aagggttact aaatgaaaaa ctgaccacta cccctggagt
    16381 aggactaccg tttactaata cttgccccga aaaaaataaa gtattatttc cttgagtgga
    16441 tacacatgct gtggtttcgt tagaagtcaa ggtaatagat gcaggtccag caggaagatt
    16501 aaatccagtt ggtccagttg gtccggttgg tccggttggt ccggttggtc cggttggtcc
    16561 ggttggtccg gttggtccgg ttggtccggt tggtccagtt ggtccagttg gtccagttgg
    16621 tccggttgat ccggttggtc cagttgaacc agtagctcct gtagaacctg tgggaccagt
    16681 agggaattga aagggttgaa caggtggaag tgtaggtcca atagaaccgg gattatgtgc
    16741 aacaaaagat aaaaactcgt ccataattta tcacctctaa aaattgtatt actattagta
    16801 aatgtactga cagagcaaac tgaaatggac aagcggttgt attttaataa attaaacaaa
    16861 atagttattt gatagaaaga gagagtagta tgattccttt agaaattaaa tataaaaagg
    16921 cgattatctt caaatcgcct tttgggtaat gcagtgtaat tttattcagt tatttgaaat
    16981 atagtttcat tcggtttaga aaatccatac aatttccttg cgaattttaa aatttcttct
    17041 tcactacttg ttaaagcttt aacatcattc ttaagggaat ggccatcctt ctttacagaa
    17101 gataattttt gttgttccgt attcagcgtg atttgttttt ctttaatcat ttcttgttgg
    17161 ttattcagag aatattgaag gacaaaaatt ataggtaaca taatagccaa agtagttata
    17221 atacggcgtc ttgttttttt tctattgcct tgttgtgtat tagggttcac ttgctgtgag
    17281 ggtatattag gacttgattg atgtgatgat acttttggga tgtttcccat taaaatgcct
    17341 ccattactga ttgtagaatt taaaccgttt aaaagtatta taaatgttta atgggaattt
    17401 tagaagatat tttaatatag ttgcatatcg taaagtttaa acaaaatcct tatttacata
    17461 aaagaaacac cgattgtctg cgaggctcct aaggataatc atcaagtaat gaagtactcg
    17521 actaattaac gatatcacga atttttgggt aaaaacactg aaaaatccgt ttaaattaat
    17581 aggagtatca tttgaaataa aaacgctatt ttaataggga agggaataat gatgattcca
    17641 tgggataagc gagtatacat tgtatcaagg tgatcatttt attacagagg ggacaattgt
    17701 agaggttagt gaaaaggcaa ataaatcatt atattggctc cagtgcatga tagctccaag
    17761 ttatgaaaaa gtgtgcggga atagtataaa gcgacttcgg ttgattcgga tagataatga
    17821 cgaagaatga gatgattaag gataggtatt gaatatgcca tatttgtatg aataaagagc
    17881 aaaatatagc caatatatag gtgctgaaat tgttctaaag gtaggaatat ctgaaatata
    17941 aataattgag gggagtgaat taaaaatgga aactagcact tttttaggat tgttttgggg
    18001 atggatcacg gttatcgtat cgggaatact tttcgtacgc ccatcggtat tacgtgaatt
    18061 gaaaaaatta gtggttgaag acagagggtt tggtattatg tacggttttt tatcgatttt
    18121 cctagggcta ggtactgtaa tcttacataa tgtatgggca ttcaactggc aggggttcct
    18181 aacggttatt gcatggcttg cattattaaa gggaatttac ataattgcat atcctgaacc
    18241 ctccaagaaa actgattttg aattaaggat actatctaca cgtatagcgc tcgctatcat
    18301 tggcgccttg gctttatgga tgcttatagt aatctatata aaataatctt tttctaatga
    18361 gaaatatact aaaatatgag aaaaggctat aataataatt ataaatttag tcctactgga
    18421 agaatccgtg gacatcaaac taaaaaggga gttgttatat tactctgtag tttggtggcc
    18481 acttttttat tttttattaa caaaatagat cagggttatt tttataaatg acgcaattaa
    18541 cttccgaatt aaaactgacc ggaaagaaat gtatgtttgt tcgggagggg tgttaaagaa
    18601 attattacaa ctgtgtaagg ttaatgtaat attaatcgat agtaaatcaa gatacttaag
    18661 tgtattttta ataggatttg aaagtactgt ttttaatata ttgggttaaa taaaatttaa
    18721 ttaggaagtg taatacaatg attgagatta aatctatgat ttattcgtac aaactaaaaa
    18781 gaagaatagc taaagattta tatggcagca gagatgagtt gacgatgtta ttaaatgaat
    18841 ttaataatat gaaaagtaaa ctgaagtctg acaaaaagaa aaataatatg ttatctcgtt
    18901 tacaattaat gtaccaaaat atgaaattag acaagcagta ttctcttccg tttgctctta
    18961 atagtaggtt attggagcga ttagaagatg aatctattca aacaactgaa gaatgtgtat
    19021 catgtctaca cgtaatgtta gaaataaatt atgagaaaat aaaacattat ggatctaata
    19081 caagtaggtc atttgttcct ttatcacagt cttccatttg tcttgctgat tttgtttgtt
    19141 tgacaggatt tgttttatta ggcttactag gaacaattac atttggaggg ataatgtaat
    19201 ctttttattc acttacataa aagaccaccc atttaaggtg tattttttag ttacatagaa
    19261 gagctcatgc gatagacagg gaagaatgac acggatgcta atttctagtt gctcattgtt
    19321 aatgcattgt gtaactagaa agataaaatg ttatgatgct atgaataaca aggaatttag
    19381 cgtttgggct agttacacaa aatataagat atgggtaact cataataaac gtgaaatgat
    19441 aaaccctatg ttgtcgcagc gattaagtga gtatgctgag ggtttgttat tgatgcaaaa
    19501 ttaagtgtta caggacttaa ttttgcatca ataacaaaag gaaaacttac tactgtaaat
    19561 aaagtgtatg tgaaataatt acaaagtcga tttataagag tcagcttata tttcgacact
    19621 ccactcaact tgtaactata gatggcagta taaatcttta tgtgttaata tacaaaaagc
    19681 cgactatact cagtcagctt tttgtatatt atattctagt atttatcgat cccaaaagac
    19741 atattctttc cgttaagttg acattaaaat cttaccaatg ttttctttta caatgacaac
    19801 aaataaagaa acatttacaa cgacacttat ttcgtttaga actccaatca tcatcacaat
    19861 gatgcttttc tttagatttc caccaatcat cattacaatg cttttcctta gaactccaat
    19921 catcatcaca atgatgcttt tctttagact tccaccagtc atcacaacaa tgctgtttct
    19981 tagaactcca gcaatcatta ttccaggaca tttttttata cctcccttca ataggattac
    20041 tatcattcta tgttttagtg aagaaatggc ttgtttataa acctattatt ttacctttat
    20101 atgatagagt gctttctact acatatagaa ttcataaaaa ctatgctaat ttccaagaga
    20161 tagtggagag aattactggt tatgacattt atcaataaac acatgttgaa gaaaacattc
    20221 tgattataaa taatatctta ttttggagta cgtttttctg aatgtatatt tcaaaacagc
    20281 ggagaaaaaa tatactatat tgctacaaac aaagcctatg tatatgtaaa gtaataggaa
    20341 aaacagctaa ctcttaaagg ggctggctta ttaaaagaaa aaaagattct tttgataaag
    20401 aggttatcta aactttaaat tcagcagaat taaatccaag tcccctcact aaacaagccg
    20461 ctaactgtta aagaattgtt tttataatta ataaagaaaa aaatgtttag tacaattgtt
    20521 tgtttttttc tttctatgtg tttgcctcgt acacttttaa gctagtggac atactttact
    20581 aatagaaagg attagggggt gaggttttgg gttctcgatt taataattgt aaaaagaaat
    20641 gtacatgtaa acaggatgat tgttgggaga tattcgaaga gtgtaaaaag gaaaagcatg
    20701 agaaatgtga taattcttgt gtacaaggaa ttagagatga gcttaagaaa ttaattaatc
    20761 gaacagttca aattaataca gagggacgta cttatgtagg tactgttgcg tctgtaagtt
    20821 gcgatgtagt taagcttgca gctattcctg gatctgttgc agtaattatc tccatttgca
    20881 aaattgaagc aattttccct cctgttacaa cgattactgc agagtttgat tttaatggtg
    20941 ttgacgtagc aaataaagca taattatgct ttgtttgtaa agccattctg atgaatggct
    21001 ttattttaat ttcgtataaa aggagaatat attctttata tagaaataag tttgaggcta
    21061 taaagagtga tgtacgaaag gagaatgaga gtgattaaat tagtgccctt taaaagatct
    21121 gatttcaaac aattaataaa ttggattcat tccgaacaat ttttaataca gtggtcagga
    21181 aatgcattta catatccttt aaacgaacag caattagaga aatatataga aagtgcaaat
    21241 acactcgctt tcaaagtaat agatgaaaag actgaagaag tacttggtca tatttcactt
    21301 ggtcaaatag acgatataaa taagtctgcg agaattggaa aagtgttagt tggtaatacg
    21361 aaaatgagag ggcgttcaat aggaaaacat atgatgaaag cagtacttca tattgcgttt
    21421 gaagaattaa aactacatag agtaactctt ggcgtgtatg attttaatac gtcggccatt
    21481 tcttgttatg aaaaaatagg atttgtaaaa gaaggtttat taagagattc aaaaaaagta
    21541 ggagaaacgt attggaattt atgggaaatg agtatgctag aatatgaatg gaataataaa
    21601 aaataatagt ttcttataat tttattatgt taattaaaag ggattggtgg gaaattatga
    21661 atagaaagac tatagtaatc acaattgcag ctgtttcagg gggaggtaaa actactatta
    21721 cagaaagttt aactcatgag ttaacaaatt caaaagcgct attttttgat agttataact
    21781 ttgataactg tcctgctgat atttgtaaat ggattgatga tggagcgaat tatgacgagt
    21841 gggtacttac accattaatt catgatattc agcatcttat acgagatagt aaattagact
    21901 atattattgt agattatcct tttgcatact taaatagaga aatggggcag ttcattgatg
    21961 taactatatt tattgacaca cctttagata ttgcaatggc tagaagaatt ttacgagatt
    22021 ttaaagaaga tactatgagt gaaatacata atgatttaaa acattacatg gcacatgcga
    22081 gaaaagttta tttagaggca attcatactg ttaaaccgaa ttcagatatc gtattggatg
    22141 gatctttttc tgtaagtgaa ataattgatc atgttgttga ggaacttgac cgaagagaag
    22201 tgattgtcaa tggttaaatg tatagaggaa tatgtacaag ttgatgattt taaaatgtat
    22261 acgaaagtat ttcaaggaaa aaagcggcag cctgttatta taatggaatc aggctacggg
    22321 gattattcaa aggcatggga ttatattgct gaaagactga cggaatttgg gacgatactt
    22381 acatatgatc gagctggatt agggaaaagt gggaagagtt tcaagcaacg tattagttct
    22441 gaaatggtca aagatttaag aacatgttta aatcttttac aactgaagcc accttatatt
    22501 tttgtagggc attcttttgg tggtataaat gcacggttat ttacggtttt ttatcccgag
    22561 gatatgttgg gaacagtttt ggttgattcg acaccagaaa attataaaga agtatttttg
    22621 ccaatcatgt ctccagaatt tcaagaagct tactataaac aatttgcata tgaaagttca
    22681 tatgaagagt ttatgtttag tctaggtgaa gcagatagac attgtaaatc aatgaacgat
    22741 attccccttg tcgtgctagc tgctggtaaa aaagcttttt attcgcaagc tgcacaactg
    22801 aaatggttac aattacaaag agaattatta caattatcca gtaaaagtaa atttataatt
    22861 gcagaacata gcggtcacta tattcaaaag gatgagccac attatattat aggtgctgtt
    22921 aagtggatac ttggggtagg ggagagataa atgtgtacac tgtatttcaa tataattggc
    22981 aagtaagaga agattggttt aagtggtgtg aacaacttac agtggaagaa ttacttcgca
    23041 aacgtgttgg tggtgttgga agtatattag aaacattatt tcatattgta gatgttgagt
    23101 atagctggat ttgtgatttg aaaggaaaag aagtagatga gccgcaattt aaggattatc
    23161 aatctattca aaaagtgaaa gcattatctc atttgtataa taaggattta gagggatttt
    23221 tacaatcgtg gacagaagac ttagagaata aaatattaaa agtttcatgg acggataaag
    23281 agtacaagta tggtgaagtg ttacgacatg ttgtcgtaca tgaaattcat catataggtc
    23341 agctatcaat atgggcaaga gagttaaatc ttcagcccgt ttcagcgaat ttaattggaa
    23401 gaggattata gacgtaaaaa ccgacttgta ctgtaaacgc aagtcggttt ttatatgtaa
    23461 gaagatttct tagttgaaat cctcggattt tctttgacgt aaatgtaaaa acattaaaat
    23521 tgtaataatg aaaaagatca tcatcgtttg tatgattaaa tttttaaact gtaacaatat
    23581 tgcccaagat gtaagagtat ctttaaaagc ttggagtgca gagtacgagg aaggttcaaa
    23641 accgtactga agtaattttt ttgtttcaat aaaagtagtg ttttcttcat cggattctaa
    23701 tattactgaa ataagcctag tatctcctag ttttgcagta ccgacaaaac tattattacc
    23761 gttagttgaa aaactagttt gcaagccatc aacaccttgg aatttaatgt tttcattgag
    23821 ggaataaatc attttatttg tgttgaaaac ttgaaaattt ttgaaggtaa attggtaaga
    23881 ggttagtttc gtcatattca gtacattagg gaaatctttt actaaatgcg ttgctagttt
    23941 agctgcatct ttcgctgttg tattcgattg tttatttgta tcttgattag ctccagtaga
    24001 gtttagaaaa ggagatggct gtgataactg tagctgtttt gctttttcat tcattaacgt
    24061 tgtaaagtta tcttcattgc caccaatgtg ttctgccagt gcgagtgcag aacgattatt
    24121 tcctgttaaa agcaatgcat gaagtaaatc acgaaccgtc gttttatcct ttgctgttac
    24181 ttgcatagga gtcgtttccg cttggaataa ttcgttactt atttttacgg attcatctaa
    24241 ctgtattttg ccgtcattta gttgttccaa tacgatatac tctgtcatta atttagacaa
    24301 agtagctgat tgtatagggg tttcttcatt ttttttataa ataacttcac ctgaattagc
    24361 atctattaaa atagctgatt tagcttgaat aattggacca tttacataaa gataaaaata
    24421 taaaacgata agtgcagtaa taataaaaga taataataaa attgtgaatt ttttcaagaa
    24481 ttgcataagc gatcctccta ctatgacatc aataataata ttgtaaaaag gaatgcttaa
    24541 ttaggaagaa agaaaaggta aagaatttct aaagaattat aaaagattat taaactttgg
    24601 atattgatgg aaaataaaag gttcaatttc ttatcatatt agaaattgaa cctaaaatta
    24661 tggtgtatta atttttatat ggtagtagtt ttacagtgaa agttgttttc ttgtcatcac
    24721 tatatacttc aatcgttcct ttatgcagtt cgacaatact ttttgcaatt gctaatccga
    24781 gtcctgatcc accagtgttt gttgaacgtg atttttcaac acgataaaaa cgttcaaaaa
    24841 tatgaggtaa atctgtacta ggaataggtt gtccgtaatt tgttatatca attgtaatca
    24901 tattattgct ttcataagcg gtaaggtcaa tataaccacc ttcgtttcca taagcgatag
    24961 cgtttataat aagattttca aatacacgca ctaatttgtc tccatcagct aataccatga
    25021 gtttttgaga ggggaaagaa ggacggcatt gaatatttgc ttcttgcact tgtattcgga
    25081 attgaacagt taattgtcca agtagctcta caatatcaat gggagcagaa tataaactta
    25141 actctttatt ttgaacacgg gtgtattcaa acaagtcatt cattaatgca tttagacgtg
    25201 ttactttacc ataaatgact tgtatgtaat gacgtaatt
//
