LOCUS       NZ_JAAVIO010000007     23908 bp    DNA     linear   CON 03-AUG-2024
DEFINITION  Bacillus toyonensis strain M5 contig7, whole genome shotgun
            sequence.
ACCESSION   NZ_JAAVIO010000007
VERSION     NZ_JAAVIO010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus toyonensis
  ORGANISM  Bacillus toyonensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 266979)
  AUTHORS   Huang,Y., Palmer,J.S., Ding,Y. and Yu,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-MAR-2020) School of Food and Advanced Technology,
            Massey University, Private Bag 11222, Palmerston North,
            Manawatu-Wanganui 4442, New Zealand
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012395365.1-RS_2024_08_03
            Annotation Date                   :: 08/03/2024 02:52:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,219
            CDSs (total)                      :: 6,078
            Genes (coding)                    :: 5,835
            CDSs (with protein)               :: 5,835
            Genes (RNA)                       :: 141
            rRNAs                             :: 17, 6, 13 (5S, 16S, 23S)
            complete rRNAs                    :: 10 (5S)
            partial rRNAs                     :: 7, 6, 13 (5S, 16S, 23S)
            tRNAs                             :: 100
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 243
            CDSs (without protein)            :: 243
            Pseudo Genes (ambiguous residues) :: 0 of 243
            Pseudo Genes (frameshifted)       :: 103 of 243
            Pseudo Genes (incomplete)         :: 148 of 243
            Pseudo Genes (internal stop)      :: 73 of 243
            Pseudo Genes (multiple problems)  :: 69 of 243
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:32:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 28022
            Orig. end                         :: 51930
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAAVIO010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23908
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23908
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23908
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13908](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13908
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            218..1486
                     /locus_tag="HB668_RS21200"
                     /old_locus_tag="HB668_21200"
     CDS             218..1486
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001084457.1"
                     /locus_tag="HB668_RS21200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21200"
                     /product="hypothetical protein"
                     /protein_id="WP_001084457.1"
                     /transl_table=11
                     /translation="MNSIILDKIVVRNNRVDYYFSIKGDLQKYFKTSNHMFLEYNYDVS
                     DISLSILAIPFVANVVPLVWITNSTIVINELDKSFYICLNNIKNAYQNMFPGVKFKGSM
                     VVGEIIDNVYIPELEAASLFSGGLDALTTFIRIKDKHPLLVTEYGWHENEIEGSKVWEA
                     DKENAVNFVKDNGLENIFIQSNYGTFIIAGNIDHDFREKLNDTWWHGLHHGLAIISAAI
                     PIAFKLKIKCIYIASSNSPLYQVTCASDPTVDNEIKYASGTVFHDGYELTRQEKIKVVV
                     DHYSASKEPVNIRVCFKNEENCCKCEKCLRTIMGIIAEGRDPREYGFNIPSNLYQYVKT
                     SLNNEVKFFTNTFIEMYWNLIQVRMKQNCDCITDKNLLNWFLDYDFKAQRRKALLKYRI
                     TKFFPILKRKISAKFSRVGTQNN"
     gene            1505..3064
                     /locus_tag="HB668_RS21205"
                     /old_locus_tag="HB668_21205"
     CDS             1505..3064
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001222557.1"
                     /locus_tag="HB668_RS21205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21205"
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_001222558.1"
                     /sec_met_domain="Polysacc_synt (E-value: 1e-09, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIQNSLKNILFGLSGQIISIGMGFVVRTVFIFTLGIEYLGVDGL
                     FTSILLMFSLANLGFDTAIIYSLYRPLAEKDIYKIQALMNLYQKAYRLIGVVVLLIGLS
                     LLPFLDHLVNADTTIKDINIIYLLFLISSVSSYYFVYKQSIIIADQSNYIISKIHTLFM
                     IISNALQIVLLIIISDYIVVLVAQLTLKVIENVYIANKANKLYPFLKEKNNAKLSKTDR
                     REFFENLYSLLLYKISGVVINATDNIVISKFIGVIWVGVYSNYLLILNTLNTLLGYLFY
                     SITASVGNLNVKENAEKKYFIFRVINFLNFWIYGFCTVCLWNLINPFITIWLGEEYVFN
                     KYVLFFILLNFFTSGMQNTTTMFRETTGLFKKGKYRPIIAAIINIVVSIILAKQIGIAG
                     VLLGTVISRLCTYFWYDPYIIFKMIFKKSVKVYFIRYILFVVLVLFSIIATDFIGYIFH
                     INIFMDMAIRSILCLIIPNLIFWMVFKEAEEYRYFLNLTRILIKKIKPKILTRKFPNDN
                     YP"
     gene            3403..5637
                     /locus_tag="HB668_RS21210"
                     /old_locus_tag="HB668_21210"
     CDS             3403..5637
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000269321.1"
                     /locus_tag="HB668_RS21210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21210"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_168387864.1"
                     /transl_table=11
                     /translation="MWRRRDNLGNLNDLDLVSKPPFHNDILTYDSTQLKWIPKSFEATN
                     STSIYVLELDRWDVKNDGTDAINTSQGINNALVWAAQQGYTEVVLPRGIYLIDKQTPIE
                     PPSHLTLNLNGSTLKMETNNLTGYAIISFRRNQVYSRITNGIIQGDRYTHDYSSGGTHE
                     AGYGIELGSFTPPADGGNNTRFVSLDNLDILDCTGDAITLNSTFGQISPFPTALASSFE
                     QGAINTTDGSLVSSTTKIRSNLQIDMNQVAIVKYGYFGLYGNGFGALGSEIKCDYYDVI
                     FYTSNNIFLSSKTNVQFFDEVEVPNGASYAKVVLHQGNVPAPANCLINVRVPSFSQYTY
                     IEKCNLHDCRRQGISVCGAKNVYIRDNDIHHIAGTNPQSGLDIEDGYDLNQYIYIERNN
                     FHDNKNYNIIVVNGKFIYISNNSIMNTITNAYVGLSINGGADRVIVTGNNIRLTKVSLL
                     GDVIFSNNYVYGAQVNVQGVYVNRSINISDNVFSNSKMIIDTPFPYAVKVDSCRFINDT
                     DKLNSLSSLYQWTLELKNEPQTISNCIFEGQDVLYLNYVPVGTVKSGWIFENIIFNNVK
                     PPTLVAGTYTNCFFKDVIFLGIASTGSTLELKGCKFFSIDRNNTLFTVNNLKAFKMIDC
                     HIEKPNGTVLNIQNVSDEIVLRGNTIKITNDTLQRAIIVLDAAFTGKQVIIQNNIINST
                     NLMQVGIDNRTTSSTPQVVIQNNVLNNAKITITGKEFLQGNIVNGVIDSN"
     gene            6249..6854
                     /locus_tag="HB668_RS21215"
                     /old_locus_tag="HB668_21215"
     CDS             6249..6854
                     /EC_number="2.7.8.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002070010.1"
                     /locus_tag="HB668_RS21215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21215"
                     /product="sugar transferase"
                     /protein_id="WP_000825901.1"
                     /sec_met_domain="Bac_transf (E-value: 2.3e-69, bitscore:
                     226.5, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLLDIFISLLLLICFFFIILLVAIIVKTQIGSPILFRQQRPGL
                     HGKPFYLYKFRTMTNERDNSGELLPDYARLTKVGKFLRKYSLDELPQLINVLKGQLSLV
                     GPRPLLMEYMPLYSQEQAKRHNVKPGITGWAQINGRNSISWDEKFKLDVWYVENQSFLL
                     DLKILYLTFSKVLKSEGITNNKHVTMPVFKGGIEHGGE"
     gene            6841..7818
                     /locus_tag="HB668_RS21220"
                     /old_locus_tag="HB668_21220"
     CDS             6841..7818
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002165241.1"
                     /locus_tag="HB668_RS21220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21220"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_000509383.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.2e-24, bitscore:
                     79.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGNKMNILFTSSGRRVTLIKKFKEVFEQVGIKGKIFTADLKETA
                     PTIYFSDKHFIVPRVNEEGYINELLKICRSEMINLIIPLIDTELILMANNSEVFEGIGV
                     KVLVSSMELNKIANNKKYTYNFFVSNNIPTPRVYSDEEIGRKEYQFPLLIKPYDGSSSK
                     GVTKIMNEKELEFFKEYIPNAMIQEYVSGEEYTIDVMVDFYGNIKTIVPRLRIETRAGE
                     VSKGVTKKDFDIIQAAETVIKALPNPIGCITLQCFKKEDGQITFIEINPRFGGGIPLSI
                     EAGANFPLWTIKMCQGEVFIDKDFNWRENLTMLRYDEAVFMESI"
     gene            7820..8515
                     /locus_tag="HB668_RS21225"
                     /old_locus_tag="HB668_21225"
     CDS             7820..8515
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016086741.1"
                     /locus_tag="HB668_RS21225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21225"
                     /product="HAD family hydrolase"
                     /protein_id="WP_000236583.1"
                     /sec_met_domain="HAD_2 (E-value: 4.2e-24, bitscore: 79.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVIQAIVFDMDDTLYKEKDYVVSGFKAVDDWIKDNYGKIGFYNIA
                     IRLFNSGERKFVFNKTLKKLDIDYDEKLISNLIEQYRFHKPDIQLLDEADWVLNNLVNT
                     VKIGLISDGYLVAQKRKINALKLKERVHSIILTDKLGKECWKPSKIPYEKISKELQVPH
                     EQCVYIGDNLSKDFITAKKLKWLTIHISREDGIYHNLIVEQAYKAHYTIDNLRRLSDIS
                     VLKHMFLDT"
     gene            8546..9709
                     /locus_tag="HB668_RS21230"
                     /old_locus_tag="HB668_21230"
     CDS             8546..9709
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (42-168). E-value:
                     2.3e-08. Score: 25.5. Matches aSDomain:
                     nrpspksdomains_HB668_RS21230_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000557690.1"
                     /locus_tag="HB668_RS21230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21230"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_168387850.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 5.6e-98,
                     bitscore: 322.5, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1e-07, bitscore:
                     25.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTVQHKKRIYLSSPHMSGNEQKYIQNAFDTNWVAPLGPNVDGFE
                     RELASFVGVRGGTAVSSGTAAIHLALQLLGIQKGDTVFCSSFTFVASANPIVYLGAEPV
                     FIDSEPETWNMSPSALAHALYEANKMGNLPKAIILVHLYGQSAKLDEILSLCHQYNVPI
                     VEDAAESLGSTYKGKASGTFGKFGVYSFNGNKIITTSGGGMLVSNDVEALERARFLATQ
                     AKDPAPHYEHSEIGYNYRLSNILAGIGRGQLEVLEDRVRARRFVYKRYYEALSHMPGFY
                     FMPELEHTRPNRWLTTLTIDEKESGISIGKLLRILAEENIEARPMWKPLHMQSLFKEMK
                     YYPHNKNEDVSQYLFQSGICLPSGSNMLAEDQQRVIQSILKAVEWKN"
     aSDomain        8672..9049
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HB668_RS21230_Aminotran_1_2.1"
                     /evalue="2.30E-08"
                     /label="HB668_RS21230_Aminotran_1_2.1"
                     /locus_tag="HB668_RS21230"
                     /protein_end="168"
                     /protein_start="42"
                     /score="25.5"
                     /tool="antismash"
                     /translation="GFERELASFVGVRGGTAVSSGTAAIHLALQLLGIQKGDTVFCSSF
                     TFVASANPIVYLGAEPVFIDSEPETWNMSPSALAHALYEANKMGNLPKAIILVHLYGQS
                     AKLDEILSLCHQYNVPIVEDAA"
     gene            10001..11938
                     /locus_tag="HB668_RS21235"
                     /old_locus_tag="HB668_21235"
     CDS             10001..11938
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274520.1"
                     /locus_tag="HB668_RS21235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21235"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_001274520.1"
                     /sec_met_domain="GATase_7 (E-value: 1.1e-20, bitscore:
                     67.8, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 2.7e-24, bitscore:
                     80.4, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAITGIIHFNNEPISIEHGTRLMSELQKYPADDIQIWHKENAFL
                     GCHAQWITPESVGEQLPFYNYEKQLAITADAIIDNRNELFEKLQVDYSDRKNMTDSELI
                     LLSYQKWGEAAPKYLVGDFAFMIWDEKKQILFGARDFSGSRTLYFYRGEEKLAFCTIIN
                     PLFTLPYIEKKLNEQWLAEFLAIPVNFESVDPQLTVYKYIEQVPPSHTILVKEGEVKFS
                     RYYTPTVGKMLNLKSNEEYEEAFREVYKSAVKARLRTHHQVGAHLSGGLDSGSVVSFAA
                     RDLRTENKKLHTYSYVPVEGFEDWTHKGRIADERPFIQSTVEHVGNIQDYYLELPERSP
                     LSEIDDWLETMEMPYKFFENTFWLSGVYEKASQQGIGVLLSGQRGNWTVSWGPILDYQA
                     MLLKKLHWIRFYRELYLYSRNIGVKKSRVFEVVRRKAFPFLHQLLFSGKQDANSVIINP
                     EFAREMNVFDRLREQEIDITGTAISNAYEMKREQFEKPYYWSINGTYETKLSLRYALWD
                     RDPTNDLRLIQFCLSVPEEQYVQNGLDRALIRRATKSFLPDKVRLNQRVRGIQGADGVY
                     RMAPFWNEFIEEVEELSVDPVISEFLNVEVIKKAISKICKEPRPEYAFDLDFRVLMRSL
                     IFYRFIKKAI"
     gene            11954..12079
                     /locus_tag="HB668_RS21240"
                     /old_locus_tag="HB668_21240"
     CDS             11954..12079
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172970.1"
                     /locus_tag="HB668_RS21240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21240"
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_000712621.1"
                     /transl_table=11
                     /translation="MKKEWKQPVLEVLNINMTMAGPGHKYPDAVQPDPDDPVKYS"
     CDS_motif       11954..12013
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKKEWKQPVLEVLNINMTMA"
                     /locus_tag="HB668_RS21240_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       12014..12079
                     /prepeptide="core"
                     /locus_tag="HB668_RS21240_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-15.80"
                     /molecular_weight="2264.4"
                     /monoisotopic_mass="2263.0"
                     /core_sequence="GPGHKYPDAVQPDPDDPVKYS"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKKEWKQPVLEVLNINMTMA"
                     /leader_location="[11953:12013](+)"
     gene            12156..13127
                     /locus_tag="HB668_RS21245"
                     /old_locus_tag="HB668_21245"
     CDS             12156..13127
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016108921.1"
                     /locus_tag="HB668_RS21245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21245"
                     /product="aldolase"
                     /protein_id="WP_000460441.1"
                     /transl_table=11
                     /translation="MFDSMGNVLYQAFGLKIVSEIPLPELSQLNEKKEVADVQVEITDL
                     SEQWCKYSAEKQKTIVVEDNVVMFHVPQTAIFSIQAGEKITFSPMADAEEDKIRLYILG
                     TCMGALLMQRKTLPLHGSVIAIDGKAYALIGDSGAGKSTLASAFLNKGYQLLSDDVVAV
                     SLLNKNTAIVHPSYAQQKLWQESINELGMEVAQLSPLFERETKYAVPVNSQFFPDPLPL
                     AGVIELVKTQGEDIETTRIEGLARLYKLYRHTFRSSLISKLGLMEWHFETSTHIASGME
                     MFQVSRPTSRFTAHELVEVILNTIQKGSMVDGCPLEKNIIKT"
     gene            13090..13398
                     /locus_tag="HB668_RS21250"
                     /old_locus_tag="HB668_21250"
     CDS             13090..13398
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128586.1"
                     /locus_tag="HB668_RS21250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21250"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_000260275.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.3e-27,
                     bitscore: 89.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2e-16, bitscore: 54.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVHSRKISLKHNVVQSKGNIVSDMDGEKVMLNVQKGKYYNLGEI
                     GGEIWELIEKPIIINQLVTMLVSNYDIERKDCEEQVLSFLECLFQEGLIQIKDQPNR"
     aSDomain        13129..13377
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HB668_RS21250_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.40E-28"
                     /identifier="RREFam002.1"
                     /label="HB668_RS21250"
                     /locus_tag="HB668_RS21250"
                     /protein_end="96"
                     /protein_start="13"
                     /score="89.7"
                     /tool="antismash"
                     /translation="VVQSKGNIVSDMDGEKVMLNVQKGKYYNLGEIGGEIWELIEKPII
                     INQLVTMLVSNYDIERKDCEEQVLSFLECLFQEGLIQI"
     gene            13435..13908
                     /locus_tag="HB668_RS21255"
                     /old_locus_tag="HB668_21255"
     CDS             13435..13908
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012261438.1"
                     /locus_tag="HB668_RS21255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21255"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_001028388.1"
                     /sec_met_domain="PF13471 (E-value: 4.9e-25, bitscore: 81.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVKRLRVFLLLNMETKLLFLEAFIFLGWARVLKSITFSKVAPS
                     LGDYMNETSVAQIQQHEDTLKEVSEAISIMSRYTFWESQCLVKAIAGMKMLEKRDIEST
                     LYLGTAKDNSGALIAHAWLRSGSFYVTGSEGMEKFTVVGSFAKRLSENTIKGE"
     gene            13910..15112
                     /locus_tag="HB668_RS21260"
                     /old_locus_tag="HB668_21260"
     CDS             13910..15112
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000409754.1"
                     /locus_tag="HB668_RS21260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21260"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_000409751.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 5.3e-65, bitscore:
                     213.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKDFGLNVEFMSKELKLLFAILKLKDDETMQTYSNEWFSDIDWE
                     LFLEQVVHHRVYPVIYQKLKQVDEEIIPSHIVQSLNRKYKKNTFQMLYLSAEMERINKI
                     CNENEIRMIFLKGPVLSQDLYGDISLRTSCDLDVLIPIQNLEKVEMLLLEQGYVKDDYI
                     QTILNDWKWRHHHITFFHPTKQIKLEIHWRLNPGPSKEPGFEELWKRKRKSTLTSNSVY
                     MLGKEDLFLFLVSHGARHGWSRLRWLVDIKKIVNQDLNWSEIHKLMKTYQMLHLGGQAL
                     ILSSQLLGVRMDERMMELVAKKHSKQLAQEALFYFKQMINLHTDPVPEEVLAYHSRHLF
                     SLMSNQQKTLFIMSQLYPYPIDAKTLPLPKFLHFLYFPLRPFLCIWRKTKKFALLLGEH
                     R"
     gene            15109..16908
                     /locus_tag="HB668_RS21265"
                     /old_locus_tag="HB668_21265"
     CDS             15109..16908
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096316.1"
                     /locus_tag="HB668_RS21265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21265"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001106590.1"
                     /transl_table=11
                     /translation="MNYIIYFMKKLYSSAGKILYVNLFGMVLISLLEGIGIILLLPMIS
                     MTGIINTGEETSFIAPVYRILQNFPKTTSLISILGIYVLIVLSQNILQRNITLRDARTQ
                     QVFVRKLRVETYSMILKAKWRFFLEKRKTNLINILTTELARVSYGINLILQLLATILFT
                     FIQVGLAFLLSPQVTVFVLGFGLLFLVASRVFIKKARILGGKTSELAKDYLSGITDHFN
                     GIKDIKSNTLEGSRLEWFQSITKKMSSEQMEYMRIRSNSQLFYKISMAILIAFFIFLSV
                     NMFQAQTAQLLLIILIFSRLWPRFMTIQSNLEQLAASIPAFKSLWELQQECNEAVEMQD
                     IYMQKHIKPICIKQGIECKDVSFRYNKQEALYALQNINVQIPINSMTAIVGHSGAGKST
                     LIDVLMGLIQPEKGQVLIDGTPLTTDNLLSLRQAISYVPQDPFLFNASIRENLMMIDSN
                     VNEEQIWAALEFAAATEFVRMLPNGLDTLIGDRGVRLSGGERQRLVLARAILRKPSILV
                     LDEATSALDTENEVKIQSAIERLKGTMTIVVIAHRLSTIRNADQVIVLGKGEIVQKGEF
                     NQLAKERKGVFRNLLGSQMEVGS"
     gene            17136..17459
                     /locus_tag="HB668_RS21270"
                     /old_locus_tag="HB668_21270"
     CDS             17136..17459
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016105867.1"
                     /locus_tag="HB668_RS21270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21270"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_001102631.1"
                     /transl_table=11
                     /translation="MNVQFKKGVLELCVLALVKRKDSYGYELVQQISNKFLISEGSVYP
                     LLRRLTKEGYFQTYLKESTEGPPRKYYQLTEQGETQLHLLVTEWSDFAKGVQEIIEGVN
                     WDE"
     gene            17452..17994
                     /locus_tag="HB668_RS21275"
                     /old_locus_tag="HB668_21275"
     CDS             17452..17994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031379.1"
                     /locus_tag="HB668_RS21275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21275"
                     /product="DUF1700 domain-containing protein"
                     /protein_id="WP_001031393.1"
                     /transl_table=11
                     /translation="MNKEQFLRELSNQLRKLPEEERKDILFDYEEHFQFGIEEGKTELE
                     IIKGLGSPKVIAKELLAMYRFDEMKKDPSTSNVTRAVMAAIGLSLFNFIIVLGPLVAII
                     GFIFSFWVGGIASVVTPFFVIVKVFMGTFIWLDLFVSITFVGVGLLLCMIAYYSTKWFK
                     RLCVRYVIWNFKMIKGE"
     gene            17995..18798
                     /locus_tag="HB668_RS21280"
                     /old_locus_tag="HB668_21280"
     CDS             17995..18798
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016512438.1"
                     /locus_tag="HB668_RS21280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21280"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_000976110.1"
                     /transl_table=11
                     /translation="MMKKILLVAIACIIIGVIGISQTYEKAVQTAEKGDKEDVIKNETL
                     KNIEVKLGAGDIVVQKSPDASFYVKQTGDVSKQEIRITEDGDTLKVIGERKKDVSFDFS
                     FYNFGFQTSTLTIFVPERSYQEIKVNSAAGQIEISDVKSDRVNVGTLAGEVDLKYVTAK
                     NVEGSTKAGEVNFKKVMGKVTAKTTSGDVYIMDHDPKYDVEASSTAGDVTITLSEKPKD
                     AVITGQTPGGDVTIFNEENKNVTIGNGSKKISGKTAAGDVTIETR"
     gene            complement(18913..19533)
                     /gene="lexA"
                     /locus_tag="HB668_RS21285"
                     /old_locus_tag="HB668_21285"
     CDS             complement(18913..19533)
                     /EC_number="3.4.21.88"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="lexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413738.1"
                     /locus_tag="HB668_RS21285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21285"
                     /product="transcriptional repressor LexA"
                     /protein_id="WP_168387851.1"
                     /transl_table=11
                     /translation="MEKLTKRQQDILDFIKLKVQEKGYPPSVREIGQAVGLASSSTVHG
                     HLSRLEEKGYIRRDPTKPRAIEILGDDRMDTETQSVIQVPIVGKVTAGLPITAVESVEE
                     HFPLPASIVSGSDQVFMLRISGDSMIEAGIFDGDLVVVRQQQSAYNGEIVVALTEDNEA
                     TVKRFYKEKDHFRLQPENSSLEPIILKQVSVIGKVIGVYRNLH"
     misc_feature    19601..19614
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.42"
                     /tool="antismash"
     gene            19675..20331
                     /locus_tag="HB668_RS21290"
                     /old_locus_tag="HB668_21290"
     CDS             19675..20331
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016111193.1"
                     /locus_tag="HB668_RS21290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21290"
                     /product="recombinase family protein"
                     /protein_id="WP_000991792.1"
                     /transl_table=11
                     /translation="MNAIVYARVSTTKEAQETSLLRQKDELLHLAERYEMNVTKVIEEQ
                     ASGYTIERDGILEVLDTIRDEQVDALLIQDETRLGRGNAKIALMHCLHKEGIKVYTHTH
                     NGELQLSDSDSMVLDIISIVEEYQRKIHNLKIKRGMQRAVEKGYRPENNLKNRHLSVGR
                     EKKEVPIEEIVRLRKSELTFEEIAATLRGFGHNVSKATVHRRYVEYTKQLLDKEE"
     gene            20377..20616
                     /locus_tag="HB668_RS21295"
                     /old_locus_tag="HB668_21295"
     CDS             20377..20616
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172959.1"
                     /locus_tag="HB668_RS21295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21295"
                     /product="DUF896 domain-containing protein"
                     /protein_id="WP_000931861.1"
                     /transl_table=11
                     /translation="MLNHELVERINFLAKKAKAEGLTEEEQRERQSLREQYLKGFRQNM
                     LNELKGIKVVNEEGTDVTPAKLKALKKQDNAKLN"
     gene            complement(20647..22230)
                     /locus_tag="HB668_RS21300"
                     /old_locus_tag="HB668_21300"
     CDS             complement(20647..22230)
                     /GO_function="GO:0008253 - 5'-nucleotidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199635.1"
                     /locus_tag="HB668_RS21300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21300"
                     /product="bifunctional UDP-sugar hydrolase/5'-nucleotidase"
                     /protein_id="WP_001075251.1"
                     /transl_table=11
                     /translation="MNQNQIVTLNILLTSDVHGTVYPIHYQDNSKAEIGLAKISTLIKK
                     ERSKNTNVLLVDNGDFIQGTPLTYHYATYEKDKKNPMSLLANYLNYDAAIIGNHEFNYG
                     MDILNHAVETANFPYLSANILDKNIKEPYFGKPYIIKHIESNIKIAILGATTHYIPNWE
                     QAHHIKDLLFEDALETIKKWVPYIRKHEQPDLLVVAYHGGFERDFQTGVPTEVLTGENQ
                     GYAMYDEIDGIDILLTGHQHREIAQTLDNGVTILQTGCNGHSVGKVKVIFEKTEQKWVK
                     KNSYAQLLPVQGIEADKDVLSLVADYEEKTQKWLDQPIGIIHGDMRISDAMQTRLQDHP
                     FIEFINKIQMDIANVSISCTSLFHNTSPGFPKHVTMRDIVSNYIYPNTLKVIRVTGADI
                     KDALELSASYFTLNKVGDIIVNPAFIEPKPAHYNYDMWEGISYVLNISKPIGERVESLQ
                     YKGATLDINEEYDVVMNNYRANGGGNFFMFQNKPVIKDIPTDMSELIANYILKHKRIEA
                     TRNNNWKVIK"
     misc_feature    complement(22379..22395)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: medium, score: 28.44"
                     /tool="antismash"
     gene            22416..23354
                     /locus_tag="HB668_RS21305"
                     /old_locus_tag="HB668_21305"
     CDS             22416..23354
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000913375.1"
                     /locus_tag="HB668_RS21305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HB668_21305"
                     /product="phosphate/phosphite/phosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_000915069.1"
                     /transl_table=11
                     /translation="MLKKVFAMSTTVVLAAGLLSGCGTKESSASKNEDTKKGYVPKTLN
                     VQFVPSQNADTLEAKAKPLENLLSDKLNIPVKVSISTNYNTIVEAMASKQVDVGFLPPT
                     AYVLAHEKKAANVILQAQRFGVDDETGAPTKDLVDFYKSEFVVKKDSNINSVKELKGKK
                     IGYQDVTSSAGYVWPAAVLLKEGVDPLKDVKPVTLKGHDQSLIALLNGDVDAAVVFQDA
                     RNIVKKDYPNIFDQTKIVKFTEKIPNDTISVRSDLDAEWSKKLQDAFIEIGKNEEGHKI
                     IKEVYSHEGYVKSDDSKFDIVRDYGKKVKTQ"
ORIGIN
        1 ataattatct ctatagatga aagagctaag gggatggggg aaacgtataa tttaaatctg
       61 attgatagag aagatttaaa taatctcgaa aaaatgataa atgcagagtt tatcacggat
      121 gttcaagtga attttgatgt agtaaatcaa tggttaaaac agttctctaa ttaacaaatg
      181 tattgtgata aaaatggcga tttattagga ggctcaaatg aatagtataa ttctcgataa
      241 aattgtcgta agaaataata gagttgatta ttattttagt attaaggggg atttacaaaa
      301 gtattttaag acaagtaatc atatgtttct tgaatataac tatgatgtat ctgacatctc
      361 tttaagtatt ttggctattc cgtttgttgc gaatgtagtt cctcttgtat ggattactaa
      421 ttcaacaata gtaataaatg aattagataa atctttttat atttgtttaa ataatataaa
      481 aaatgcatat caaaacatgt ttcctggtgt gaaatttaaa ggatccatgg ttgtaggaga
      541 aattattgat aatgtttaca ttccggaact tgaagcggca tctttattta gtggtggatt
      601 ggatgcactt actacattta taagaataaa agataaacac cccttgctag ttactgaata
      661 tggatggcat gaaaatgaaa tagagggtag taaagtatgg gaggcagata aagaaaatgc
      721 cgtaaatttt gtaaaggata atggactaga aaatattttt atacaatcta actatgggac
      781 ctttataatt gcagggaaca ttgaccatga ttttagagaa aagttaaacg atacatggtg
      841 gcatggattg catcatggtc tagcaataat atctgcagct attccaatag cttttaaact
      901 taagataaaa tgtatatata ttgcaagttc taattcccca ttatatcaag ttacttgtgc
      961 atctgatcca actgtggata atgaaataaa atatgcatct ggaacagtct ttcatgatgg
     1021 atacgaactt actagacaag aaaagattaa agttgttgtg gaccattatt cagctagtaa
     1081 agaacctgtt aatatcaggg tatgttttaa aaatgaagaa aattgttgta aatgtgaaaa
     1141 atgtttaaga acaattatgg gaattattgc tgaagggaga gaccctcgtg aatatggttt
     1201 taatattcca agtaatcttt atcagtacgt taaaacttct ttaaataatg aggtgaagtt
     1261 ttttactaat acattcattg aaatgtattg gaatttaatc caagtgcgaa tgaaacaaaa
     1321 ttgtgattgt attacagata aaaatttact aaattggttt ctagattatg atttcaaggc
     1381 gcaacgaaga aaagcgttat taaaatacag gataacaaag tttttcccga ttttaaagag
     1441 gaagattagt gccaaattta gtagagtggg tacgcaaaac aattaaaata tagaaggtat
     1501 tacgatgaga atacaaaact ccttaaaaaa tattttattc ggtttgtctg gacaaataat
     1561 tagtattggt atgggatttg ttgttcgaac tgtttttatt tttacactcg gtatagaata
     1621 tttaggtgtg gatgggcttt ttacaagtat actattgatg ttttccctag ctaatttagg
     1681 atttgataca gctataatat atagtttata taggccatta gctgagaagg atatttataa
     1741 aatacaggca ttaatgaatt tatatcaaaa agcatacaga ttaataggag tagtagtttt
     1801 attaataggg ttatctctat tgccatttct tgatcattta gtgaatgcag atactacgat
     1861 taaagacatt aacattatct atcttttatt tttaataagt tcagtgtcat catattattt
     1921 tgtatataag caatctatta ttattgctga tcaaagtaac tatattattt ctaaaataca
     1981 cactttgttc atgattatat ctaatgcatt acaaattgtt ttattaataa ttattagtga
     2041 ttacattgta gtactggtag ctcaattaac attaaaagta attgagaatg tatatattgc
     2101 aaataaggca aataaattat atccattttt aaaagaaaaa aataatgcga aattatctaa
     2161 gacagacaga cgtgagtttt ttgagaattt gtattccttg ttgctatata aaattagtgg
     2221 tgtagtaatt aatgcaacag ataatatagt tatatcgaaa tttattgggg ttatttgggt
     2281 tggggtttat tcaaattatt tgttgatctt aaatacatta aataccttat taggctattt
     2341 gttttattct atcactgcta gtgttggaaa tttgaatgtg aaagaaaatg cagaaaaaaa
     2401 atattttatt tttcgtgtaa ttaacttttt aaatttttgg atatatggat tttgtacagt
     2461 ttgcctttgg aatttgataa atccttttat aacaatctgg ttaggtgagg aatatgtgtt
     2521 taataagtat gtattatttt tcatattact taattttttc acttcaggaa tgcaaaatac
     2581 aactacaatg tttagagaaa ccacaggttt atttaaaaaa gggaagtaca gacctattat
     2641 agcggcaatt ataaatattg tagtttctat aattcttgcg aaacaaatag gaatagcagg
     2701 agtgctttta gggactgtta ttagtagatt atgtacttac ttttggtatg acccttatat
     2761 tatatttaaa atgattttca aaaaatctgt aaaagtatat tttattagat atattttgtt
     2821 tgtagtgctt gtattatttt ctattatagc aacggatttt attggttata tttttcacat
     2881 aaatatattt atggacatgg caatacgtag tattttgtgt ctgattattc cgaatctgat
     2941 cttttggatg gtatttaaag aggcggaaga gtatagatat ttccttaatt taacccggat
     3001 attaataaaa aaaataaagc cgaaaatatt aactcggaaa tttccgaatg ataattatcc
     3061 ataaattata attttatttt ttccatatca cagtaaaaaa tgctttattt acggaagaga
     3121 ttttaggttg ttctgaaaat aatagtaggt aataataggg gcgttaggta taaagagtat
     3181 agtgtctttt taataatatt gtaagtttaa atagttataa ataaaagagt attgaaatga
     3241 aaacagctag taagaataga cctttttaga aaggaattgt aaaaagactt tctaaataat
     3301 ggatctctaa aaacaataaa aagtgatatt acttctctta tatccaatca atttacctta
     3361 tgaaacataa gatgtagaaa agcaaaaaag aggtgtgaat tgatgtggag aagaagggat
     3421 aatcttggga atttgaatga tttagatttg gtgtccaagc ctccttttca taatgacatt
     3481 ttaacttatg atagtacgca attaaaatgg attccaaaat catttgaagc tacaaattct
     3541 acaagtatat atgtattaga attagataga tgggatgtta agaatgatgg gactgatgct
     3601 atcaatactt cccaaggtat taataatgct ctagtatggg cggctcaaca aggttatacg
     3661 gaagttgtgt tacctagagg aatatatttg attgataaac aaacacccat cgaaccacca
     3721 agtcatttaa ctttgaatct aaacggttcg acattaaaaa tggaaacaaa taatttgact
     3781 ggatatgcaa ttataagttt tcgtagaaat caagtatatt ctaggataac aaatggtatt
     3841 atccaaggag atagatatac acatgattac tctagtgggg gaacacatga ggcagggtac
     3901 ggcattgaat tggggagttt tactccacct gctgatgggg ggaacaatac acggtttgta
     3961 tctttagata atctagatat tttagattgt acaggagatg ccattacact gaacagtact
     4021 tttgggcaga tttcaccttt tcctacagca ttagcaagtt catttgaaca gggagcaatt
     4081 aatacaacag atggttcatt ggtaagtagt acaacaaaga tacgttccaa tttgcaaatt
     4141 gatatgaacc aagtggctat tgtaaagtat ggttactttg gattatatgg aaatggattt
     4201 ggagcattgg gttctgaaat aaaatgcgat tattatgatg tcatttttta cacttcaaac
     4261 aatatatttt tatcttcaaa aaccaatgta caattctttg atgaagtaga agtccctaat
     4321 ggagcaagtt atgctaaagt tgttttgcat caagggaatg ttcctgctcc tgcaaattgt
     4381 ttaataaatg ttcgggtacc ttctttttcg caatatactt atatagaaaa atgtaattta
     4441 catgattgcc gtagacaagg gattagtgta tgtggggcaa agaatgtata tattcgagat
     4501 aatgatattc atcacatcgc aggtaccaat ccacaaagtg gactagatat tgaagatgga
     4561 tatgatttaa atcaatatat atatattgaa agaaataatt ttcatgataa taaaaattat
     4621 aatattattg ttgtaaatgg gaaatttatc tatatatcga ataattctat tatgaatacc
     4681 attacaaatg cttatgttgg gttgtctatt aatggtggtg cagatagggt aatcgtaaca
     4741 gggaataata tccgattaac caaggtctct ttgttaggag atgttatttt ttccaataat
     4801 tatgtatacg gagcgcaagt aaatgttcaa ggtgtatatg taaatcgatc tattaatata
     4861 tcggataatg ttttttctaa tagtaaaatg attattgata ctccctttcc atatgcggtt
     4921 aaagttgatt cctgtcgttt tataaacgat acagataaac ttaattcctt gtcatcattg
     4981 tatcagtgga cattagagct gaaaaatgaa ccgcaaacta tctcaaattg tatatttgaa
     5041 ggacaagacg ttttgtattt aaattatgta ccagtaggaa cagttaaatc aggatggata
     5101 tttgaaaata ttatatttaa taatgttaaa cccccaaccc tagttgcagg gacgtataca
     5161 aattgctttt ttaaggatgt aatctttttg gggatagcaa gtacaggaag cactttagaa
     5221 ttaaaaggtt gcaagttctt tagtatagat agaaataaca cgttatttac agtgaataac
     5281 ctcaaagcat tcaagatgat agattgtcat atagaaaaac caaatggtac ggtcttgaat
     5341 attcaaaatg tatctgatga aatagtgtta aggggaaata ctataaaaat tacaaatgat
     5401 actcttcaga gagctattat tgttttggat gcagcgttta ctggtaagca agtgataatt
     5461 caaaataata ttataaattc cacaaatttg atgcaagttg ggatagataa tagaacaacg
     5521 agtagtacac ctcaagtagt aattcaaaat aacgtgttaa ataatgcgaa aattacaatt
     5581 acggggaagg aatttttaca aggaaatatt gttaatggtg taatcgattc aaattaatgc
     5641 atggtgataa ttaaatttga atagtttcaa aaagttatga gaaatgaagt agagtggctc
     5701 ttaataaata tgtctataaa gtattatata atggtacatg gaagagtttt gtccaatgta
     5761 atcattcgaa atagtctaat tcctaataga taatatgctt attgactttt agttactact
     5821 atagaaaaga gaaaagctat tatgtttttt ataaacataa tagctttttg ttattacgtt
     5881 aactgcatac taaaaaatag tgagtaggag aatgttttaa taataaatgt ttttttatac
     5941 tattaagcgt tgtttataaa attgtttttg tgaatatact ttttgagatt tttacagtgt
     6001 gtaatagtct cttggataag catttggaaa atatattttg cacctatgtg tattgctttc
     6061 ttctacttat taagttttaa agttgtgtac taaagaaaat gtttgcaggt gataagtaaa
     6121 gaaaaattga atacaattct ttacttacaa cttgaaaata cttgatttca atccgtaatg
     6181 aatactttat atattatttc actttggaaa agcatttgta ataatttaag atgggggaat
     6241 gattggtaat gaagagactg ttggatatct ttatttcttt attattatta atttgctttt
     6301 ttttcattat tcttttagta gcaattatag ttaaaaccca gataggatca cctattttat
     6361 ttagacaaca acgtccaggg ttacatggaa aaccctttta tctttataaa tttcgtacga
     6421 tgaccaatga gcgagataat agcggggagc tcttaccaga ttacgctaga ttaactaaag
     6481 ttggaaaatt cctgaggaaa tatagtttgg acgaattacc acaattaata aatgtgctaa
     6541 aaggtcaatt aagtttggtg ggccctcgac cattattaat ggaatatatg cctttatatt
     6601 cgcaagagca agctaaaagg cataatgtta aacccggaat cactggatgg gctcaaatta
     6661 atggaagaaa tagtatctca tgggatgaga aatttaaatt agatgtatgg tatgttgaga
     6721 atcaaagttt tcttttagat ttgaaaattt tatatctaac ttttagtaag gttttaaaat
     6781 cggaagggat aacaaataat aagcatgtga ctatgccagt ttttaagggg ggaatcgagc
     6841 atggggggga ataaaatgaa cattttgttt actagctctg gtaggagggt cactttaatt
     6901 aaaaaattta aggaggtatt tgaacaagta ggaatcaaag ggaaaatctt tactgcagac
     6961 ttaaaagaaa ctgctcctac catttacttt agcgataagc attttattgt tccgcgtgta
     7021 aatgaagaag gatatataaa tgaattgtta aaaatatgta gatccgaaat gataaatcta
     7081 ataattccgt taattgatac ggaattaatc cttatggcta ataattcgga ggtttttgaa
     7141 ggtattggtg taaaagtact agtttctagt atggaattaa ataaaattgc taataacaaa
     7201 aaatacacat ataacttttt tgtctctaat aatataccaa ctcctagagt gtatagtgat
     7261 gaagagattg gaagaaagga atatcaattt ccactattaa ttaaacctta tgatggcagt
     7321 tctagtaaag gtgtaacaaa aataatgaat gaaaaggaat tggaattttt taaggagtat
     7381 atacctaacg ctatgataca agagtacgtt tcaggagagg aatacactat agatgtcatg
     7441 gtagatttct atgggaatat aaaaacgatc gttcctagat tgcgtataga gacacgagca
     7501 ggtgaggtaa gtaaaggtgt gaccaagaaa gattttgaca tcatccaagc agcagaaact
     7561 gtaataaaag ctcttcctaa tcctattgga tgtattactt tacaatgttt taaaaaggag
     7621 gatgggcaaa ttacgtttat tgaaataaac cctcgttttg gaggaggaat accactatca
     7681 atagaagcag gagcgaattt tccactttgg acaattaaaa tgtgtcaggg ggaagtcttt
     7741 atagataaag actttaattg gagagaaaat ttaacaatgc ttagatatga cgaagcggtt
     7801 tttatggaga gtatttaata tggtgattca agcaattgtt tttgatatgg atgatacttt
     7861 atataaagag aaagattatg tcgtaagtgg ctttaaagca gtggatgatt ggattaaaga
     7921 taactatgga aaaattggtt tttataatat cgcaattcga ttattcaatt caggtgaaag
     7981 aaagtttgtg tttaataaaa cacttaaaaa gttagacatt gattatgatg aaaaattgat
     8041 tagtaatttg atagaacagt ataggttcca taaaccagat attcaattgt tggatgaagc
     8101 ggattgggta ctaaataatt tggttaatac cgttaaaata ggacttattt cagatggata
     8161 tttagttgct caaaaaagaa aaataaatgc attaaagtta aaagagaggg ttcattcaat
     8221 aattctcact gataagctag gaaaagaatg ttggaaacca agcaaaattc cttatgaaaa
     8281 aataagtaag gaattacagg tgcctcatga gcaatgtgtc tatataggag ataatttaag
     8341 taaggatttt ataacggcca agaaattgaa atggttaacg atccatatta gtagagaaga
     8401 tggaatttac cataatctta tagttgagca agcttataaa gcacattata caattgataa
     8461 tttaaggaga ttatctgata tatctgtatt aaagcatatg tttttagata catagtattt
     8521 aaatatgtat aaaggatgtg tttacatgca cacagttcag cataaaaagc gaatttacct
     8581 ttcctctccg cacatgagtg ggaatgaaca aaaatatatc caaaatgcat ttgatacaaa
     8641 ctgggttgct cctcttgggc caaatgtcga tgggtttgaa cgagaacttg catcttttgt
     8701 aggagttaga ggaggtactg cagttagttc aggtactgct gctattcatt tagctttgca
     8761 gttattaggt attcaaaagg gagatacagt attttgttcc agttttactt ttgtagcgag
     8821 tgcaaatccg attgtttatt tgggagcgga accggtattt attgactcag aaccggaaac
     8881 ctggaatatg tcaccgagtg cattggcaca tgcattatat gaagctaata aaatggggaa
     8941 tttgcctaag gctatcattc ttgttcattt atatggtcag agtgctaaac tagatgaaat
     9001 tctctcactt tgtcatcaat ataatgttcc tatagttgag gatgcagcag aatctcttgg
     9061 ttctacatat aaaggaaaag caagcggtac attcgggaaa tttggtgttt attcatttaa
     9121 tggaaataaa attattacaa cttcaggtgg tggaatgcta gtttctaatg atgtagaagc
     9181 attggaaaga gcgagatttt tagcgacaca agcaaaggat ccagctccac attatgagca
     9241 tagtgagata gggtataatt atcgactgag taatatttta gctggtattg gtagaggaca
     9301 attagaagtg ttagaagata gggtgagagc tagaagattt gtatataaac ggtattacga
     9361 agcgctatct cacatgccag ggttttattt tatgcctgaa ttagaacata ctcgcccaaa
     9421 tcgttggctt actacattga caattgatga aaaggaatct gggatttcta ttgggaaatt
     9481 gttgagaatt ttagcagaag agaacattga agcgcgtcct atgtggaagc cacttcatat
     9541 gcagtcgctc tttaaagaga tgaagtatta tccgcataac aaaaatgaag atgtgtcgca
     9601 gtacctattt caaagtggaa tttgtttgcc ttcaggatct aatatgttag cagaagatca
     9661 acaaagggta attcaaagca ttttaaaagc tgtagaatgg aagaattaaa agaaaagtaa
     9721 gtgaaaatgg aatttgaatt agatttgtat acgtaccact aattgttctt tataatgaat
     9781 cttttctagt gttcagtttc aatttacata aaaaaaggga ggagtataga tttggaaatg
     9841 tctataatat ataagtctga gagtaaatta aagcatgtaa ttgagaaagt aataaaaata
     9901 aaaaatttcg ttctttaaaa agaatgataa aggggtatgt ttaacgaatt taatatgtaa
     9961 atagtaattg tagtaacttt tcatatatta ggaggaagaa atgagcgcta taactggcat
    10021 tattcacttt aataatgaac ctatatcaat tgaacatggc acacgattaa tgagtgaatt
    10081 acaaaagtac cctgctgacg atattcaaat atggcacaaa gaaaatgctt ttctaggatg
    10141 tcatgcacaa tggattacac cagagtcagt tggtgaacaa ttaccctttt ataattatga
    10201 aaagcaattg gcaattacag cagatgctat tattgataat cgtaatgagt tatttgaaaa
    10261 attacaagtg gattattcgg atagaaaaaa catgacagat agtgagttga ttttactctc
    10321 ttatcagaaa tggggggaag cggctccaaa atatttggta ggcgattttg cctttatgat
    10381 ttgggatgag aaaaaacaaa ttctttttgg tgccagagat ttttcaggaa gtcggaccct
    10441 ttatttttat cgtggtgagg aaaaacttgc tttttgtacc attataaatc cgttatttac
    10501 tctaccgtat attgagaaaa aattgaatga gcagtggctt gctgaatttt tagctatacc
    10561 tgtaaatttc gaatcggtag atccacagtt aacagtttac aaatatatag aacaagtgcc
    10621 tccatcacac actattttgg taaaggaagg cgaagtaaag ttttcacgat actatacacc
    10681 aactgttggg aaaatgctta atttaaaatc aaatgaagag tatgaagagg cgtttcgaga
    10741 ggtgtataaa agtgcagtga aggcacgttt gcgaacacac caccaagtcg gagcccattt
    10801 gagtggaggg ttagactcag gttctgtcgt tagttttgct gcaagggatt tacggactga
    10861 aaataaaaaa ttacatacgt atagttatgt tccagtagaa ggatttgaag attggacaca
    10921 caaaggtagg atagctgacg aaagaccatt tattcaatcg actgtagagc atgtagggaa
    10981 tatacaggat tattatttag aattgccaga gagaagccca ctatcggaaa ttgatgattg
    11041 gctggaaaca atggagatgc catataaatt ttttgagaat actttttggt tgagtggagt
    11101 ttatgaaaaa gcatctcagc agggaatagg agtacttctt agtggtcaaa gaggtaattg
    11161 gacagtatca tggggaccta ttttagatta ccaggcaatg ttattgaaaa agctacattg
    11221 gattcgtttt tatcgtgaac tatatttata tagtagaaat ataggagtaa aaaaatcacg
    11281 tgtttttgaa gtggtaagac gaaaggcatt tccatttttg catcagttac ttttttcagg
    11341 aaaacaagat gcaaattccg taataattaa tccggaattt gcaagggaaa tgaatgtttt
    11401 tgacagactt agagaacaag aaatcgatat aacaggcacc gctatttcta atgcatatga
    11461 aatgaaaaga gaacagtttg aaaaaccata ttattggagc ataaatggca cgtatgaaac
    11521 gaaattatca ttacgttatg ccttatggga tcgtgatccc acaaatgact tacgattgat
    11581 tcaattttgt ttgtcagtcc cagaagaaca gtatgttcaa aatggtttag atagagccct
    11641 gatccggaga gccacaaaga gcttccttcc tgataaagta cgattgaatc aacgggttcg
    11701 cggtattcaa ggtgcagatg gtgtttaccg tatggctcct ttttggaatg aatttattga
    11761 ggaagttgaa gaacttagtg tagatccagt aatctctgaa tttctaaatg tagaggtaat
    11821 taagaaagct atctcaaaaa tttgtaaaga acctcgacca gaatatgcat ttgatttaga
    11881 ttttagagtt ttaatgcgca gcttaatctt ctatcgattt ataaaaaaag caatatgaaa
    11941 ggaggtgata cgtatgaaaa aggaatggaa acaacctgta ttagaagtac ttaatattaa
    12001 tatgactatg gctgggcctg ggcataaata tccagatgct gttcaacctg acccagatga
    12061 tccagttaag tacagttaag tcattggaaa aataaagctc ttatatagct ttattatata
    12121 agagctttca aaaaattgac aatgtggggg ataggatgtt tgattctatg gggaatgtgt
    12181 tatatcaagc tttcgggtta aaaatagtaa gtgaaattcc attacccgaa ttgtctcagc
    12241 tgaatgaaaa aaaagaggtg gcagatgttc aagttgaaat aacggatttg tcagaacagt
    12301 ggtgtaaata tagcgcggaa aagcaaaaaa caattgtagt ggaggataat gtagttatgt
    12361 ttcatgttcc tcaaactgca atattttcta tacaggccgg cgagaaaatc accttttcac
    12421 ctatggcaga cgcagaagaa gataaaattc gcttatatat tctaggaact tgtatggggg
    12481 cgcttttaat gcaacgtaaa acactcccat tgcatgggag tgtaattgct atagatggaa
    12541 aagcatacgc attaattggt gattcaggag ctggaaaatc aacgttagcc tcggcttttt
    12601 tgaataaagg atatcagctt ttaagtgatg atgtagttgc tgtgtctctt ttgaataaaa
    12661 atactgcaat agttcatcct tcttacgcac aacaaaaatt atggcaagag agcataaatg
    12721 agttggggat ggaagtagcg caattgagcc ctttgtttga aagagaaacg aagtatgctg
    12781 ttcctgtgaa ttctcaattc tttccagatc cattacctct tgctggtgtt attgaattag
    12841 taaaaacaca gggagaagat attgagacga cccgtataga agggctcgca cgcttgtata
    12901 aattataccg tcatactttt aggagttctt tgatttctaa attaggatta atggaatggc
    12961 attttgaaac ttcaactcat attgcaagtg gaatggaaat gtttcaagta agtcgcccga
    13021 cttcaagatt tacagctcat gagcttgtgg aagttatttt aaatactata cagaaaggga
    13081 gtatggttga tggttgtcca ctcgagaaaa atatcattaa aacataacgt tgtccaaagt
    13141 aaaggtaata tagtaagcga tatggatgga gaaaaagtta tgttaaatgt ccagaaagga
    13201 aagtactata acttaggtga aataggcgga gaaatatggg agcttattga aaagccaata
    13261 ataattaatc agcttgttac tatgctagta tccaactatg atattgaacg aaaagattgt
    13321 gaagagcaag ttctttcctt tttagagtgt ttatttcaag aagggttaat tcaaataaaa
    13381 gatcagccta atagatagat ttgtaatttc aaaagaactg ttaggaaggg attaatgaat
    13441 attgtgaaaa ggttaagggt atttttattg ctgaacatgg aaacaaagct tttattttta
    13501 gaggctttta tttttttagg atgggcgcgt gtactaaaaa gtattacctt ttccaaagtt
    13561 gcaccttctt taggggatta catgaacgaa acatcagttg ctcaaattca gcaacacgag
    13621 gatacactaa aggaggtgtc cgaagcaatt tctattatga gtcgttatac tttttgggaa
    13681 agtcaatgtc tcgttaaagc gatagctggg atgaaaatgc ttgaaaaacg tgacattgag
    13741 agtactcttt atttaggaac tgctaaggat aatagtgggg cactaattgc acatgcatgg
    13801 ttacgtagcg gttcttttta tgttactgga tcggaaggaa tggagaaatt cactgtcgtt
    13861 ggatcatttg caaagaggct aagtgagaac actattaaag gagagtaaaa tggagaaaga
    13921 ttttggtctt aatgtagagt tcatgtctaa ggaattgaaa cttctttttg caattttgaa
    13981 gttaaaagat gatgaaacaa tgcaaactta cagcaatgaa tggttttcgg atattgattg
    14041 ggaattattt cttgaacagg ttgtgcatca tcgcgtttat ccggtgatat atcaaaaact
    14101 taaacaggta gatgaggaaa taattccttc acatattgta caatccttga atagaaaata
    14161 taaaaaaaat acatttcaaa tgctttattt aagtgctgaa atggaacgaa taaataaaat
    14221 atgtaatgaa aatgagattc gtatgatttt tctaaaaggg cctgtactat ctcaggattt
    14281 atatggagat atttctttac gaacatcctg tgatttggac gttcttattc caattcaaaa
    14341 tttagaaaaa gtagaaatgc tacttttaga gcaggggtat gtaaaagacg attatattca
    14401 aacgatatta aatgattgga aatggaggca tcatcatata acattttttc atccgacaaa
    14461 acagattaag cttgagattc attggcggtt aaatcccgga cctagtaagg aacctgggtt
    14521 tgaagagctt tggaagcgaa agagaaaaag cacccttacg agtaattccg tatatatgct
    14581 agggaaggaa gatttatttt tatttcttgt atctcatggt gctagacatg gttggtccag
    14641 attacgctgg ttagtagata taaaaaaaat tgtcaatcaa gatcttaatt ggagtgagat
    14701 tcataaacta atgaaaacat atcaaatgct acatttagga ggacaagcat taattttgtc
    14761 atctcaattg ctaggtgtac ggatggatga aagaatgatg gaattagtag ctaaaaaaca
    14821 ttcaaaacag ttagcgcaag aagccttgtt ttatttcaag caaatgataa acttgcatac
    14881 cgatccggtt cctgaagaag tacttgctta tcatagtcga catttatttt cgttaatgtc
    14941 taatcagcaa aaaactttat ttattatgag ccaactatat ccttatccaa ttgatgcgaa
    15001 aacattgccg ttacctaaat ttcttcattt tttatatttt cctttacgtc cgtttctatg
    15061 tatttggaga aaaacgaaga agtttgcttt gttattgggg gaacatcgat gaattatatt
    15121 atatatttta tgaagaaatt atattcttca gcaggaaaaa tactgtatgt gaatttattt
    15181 ggtatggtgt taatcagttt acttgaaggg ataggtatta ttttattact tcctatgata
    15241 agtatgactg gaataattaa tacaggtgag gagacttctt ttattgcacc tgtctataga
    15301 attttgcaga atttccctaa aacaacaagt ttaatttcta ttttaggtat atatgtatta
    15361 atagtgttaa gtcaaaatat actgcaaaga aatataacgt taagagatgc gagaacgcaa
    15421 caagtttttg tacgaaagtt aagagtagaa acatatagta tgattttaaa agcaaagtgg
    15481 agattttttt tagaaaaaag gaaaacaaat ctaattaata tattaactac agaattagct
    15541 cgtgttagtt atgggattaa tttaatttta caattgctag ctactattct atttacattc
    15601 atacaggtag ggcttgcgtt tttattatct ccccaagtca ctgtatttgt tttgggcttt
    15661 ggcttattgt tcttggtagc ttctcgtgtt tttataaaaa aagcacggat actaggcggt
    15721 aagacctcag aattggcaaa agactatctt tctggtataa cagatcattt caatggaatt
    15781 aaagatataa agagcaatac tttggaagga tcacgtttgg agtggtttca atctataaca
    15841 aaaaagatga gtagcgaaca aatggagtat atgagaataa ggtcaaactc tcaattgttt
    15901 tataaaattt caatggctat attaattgca ttttttatat ttttgtcagt aaatatgttt
    15961 caagcgcaaa cggcccagtt actattaatc attctcattt tttcaagatt atggccaagg
    16021 ttcatgacga ttcagtcaaa tttagaacaa ctggctgcaa gcattcctgc ctttaagtca
    16081 ttatgggaat tgcaacagga gtgtaatgaa gcggttgaaa tgcaggatat atacatgcaa
    16141 aaacatataa agccgatttg tataaaacaa ggtattgagt gtaaggatgt ttcttttcgt
    16201 tataataagc aagaagcttt atatgcactt caaaacatta atgtacaaat tccaataaat
    16261 agtatgacgg caattgtagg acattctggt gctgggaaaa gtacattaat tgatgtgtta
    16321 atggggttaa tccaaccaga aaaaggtcaa gtgttaatag atggtacccc tcttacaact
    16381 gataatttat tatcattaag acaggctatt agctatgtac cacaagatcc gttcttattt
    16441 aatgctagta taagagagaa tttaatgatg attgactcga atgtaaatga agaacaaatt
    16501 tgggctgcat tagaatttgc ggcagcaact gaatttgtac gaatgcttcc aaatggactt
    16561 gatacactga ttggagatcg tggggtgagg ctttcaggtg gtgaacgtca gcgacttgta
    16621 ttggctcgag ctattttaag aaaaccgtcg attttagtat tagatgaggc tacgagtgcg
    16681 ttagatactg aaaatgaagt gaaaatccaa tcagcaatag aaagattgaa aggaacaatg
    16741 actattgttg ttattgcaca tcgcttatct actatacgca atgcagatca agttattgtt
    16801 ttaggaaaag gtgaaattgt tcaaaaaggt gaatttaatc aactagctaa agaaagaaaa
    16861 ggtgtatttc gaaatttact agggtcacaa atggaagttg gttcttagag gagaaaaatt
    16921 gaatgaagct ttgtatgaat gcagttcgaa tcgaataaaa tctcgaataa tggtgaacta
    16981 caacagaatc ttattcggga ttttatttgc gcgtttttaa agtcagtgaa tacatataaa
    17041 caagtacctt gcaataaata gtaccaagtg gtatattatg gatatatcta gtaccgtgta
    17101 ttgaacagta ctaaactaag aaaggaggat tacatttgaa cgttcagttt aaaaaaggtg
    17161 tgttagagct atgtgttttg gcacttgtga aacgtaaaga tagttacggt tatgaacttg
    17221 tacagcaaat ttcaaataaa tttttaatat cggaaggttc agtatatcca ttattacgtc
    17281 gtttaacgaa agagggatat tttcaaacgt atttaaaaga gtccacggaa ggaccgcctc
    17341 gtaaatatta tcagctaaca gagcaaggag agacgcaact tcatttgtta gtaacagagt
    17401 ggagtgattt tgcgaaaggg gtacaagaaa ttattgaagg ggtgaattgg gatgaataaa
    17461 gaacaattcc ttagagaatt atcgaatcag cttagaaagt taccggaaga agagaggaaa
    17521 gatattttat ttgattatga agagcacttt cagtttggga tagaagaagg gaaaactgaa
    17581 ttagaaataa taaaaggact tggttctcct aaagtaattg caaaagaatt acttgcgatg
    17641 tatcgtttcg atgaaatgaa aaaagatcca tcgacttcaa atgttacaag agctgtcatg
    17701 gcggcgattg gacttagttt atttaatttt attatcgtgt taggcccttt agttgcaatt
    17761 atcggtttta tattttcttt ttgggtcggt gggattgcta gtgtagtgac accatttttc
    17821 gttatcgtaa aagtatttat gggcactttt atatggttgg atcttttcgt tagtataaca
    17881 tttgttggag taggtttgtt gttatgtatg atagcgtatt atagtacgaa gtggtttaaa
    17941 agattgtgcg tacgttatgt gatatggaac ttcaaaatga taaaagggga gtagatgatg
    18001 aaaaaaatat tgttagtagc tatcgcttgt atcattattg gagtaatagg gatttcacaa
    18061 acatatgaaa aagcagtaca aactgcagaa aaaggcgata aagaagacgt aattaaaaac
    18121 gaaacgttaa aaaatataga agttaagtta ggggctgggg atattgtcgt ccaaaaatct
    18181 ccggatgcct ctttttatgt aaagcaaaca ggagatgtaa gtaaacaaga aattcgtatt
    18241 actgaagatg gtgacacatt aaaagttatt ggggaaagaa aaaaagatgt ttcgtttgat
    18301 ttttcctttt acaatttcgg atttcaaacg tctacattga ctatatttgt accagaacgt
    18361 tcttaccaag agatcaaagt aaattcagca gctggacaaa tagaaataag tgatgtgaaa
    18421 agtgaccgcg taaatgttgg aacgctggca ggagaagtgg atttgaagta tgtaacagct
    18481 aagaacgtag agggatctac aaaagctggt gaggtgaact ttaaaaaggt tatggggaaa
    18541 gtaacagcaa aaacgactag tggggatgta tatattatgg atcatgatcc taagtatgat
    18601 gtagaggcaa gctcaactgc tggagatgta actattactt tatcggaaaa accaaaagat
    18661 gcagtaataa ctgggcaaac tcctggtgga gatgtgacaa tttttaatga ggaaaataaa
    18721 aacgtaacaa ttggtaatgg gagtaaaaag attagcggca aaacggctgc tggagatgtt
    18781 actatagaaa cacgttaata atagatgaga agatagattc attcgagttt tttggaatga
    18841 attaaaatct accaatatat aaaagaagat aattccctat ataaataagg gaattatctt
    18901 cttttattat ttttaatgta aattacgata tacgccaatt acttttccaa taactgacac
    18961 ttgttttaaa atgataggtt ctaatgaaga gttttccggc tgtagacgga agtggtcttt
    19021 ttctttatag aaacgtttaa cagttgcttc gttatcctct gttaaggcaa cgacaatttc
    19081 accgttgtat gcagattgtt gttggcggac aacaactaaa tctccatcaa agataccagc
    19141 ttcaatcatg ctatctccag aaatacgtaa cataaatact tgatctgatc cagaaacgat
    19201 actagctgga agtgggaagt gctcttctac actttcgact gctgtaatcg gtaaaccggc
    19261 agtaactttt ccgacgattg gaacttgaat aacagattgt gtttctgtat ccattcggtc
    19321 atcgcctaaa atttcgattg ctcgtggttt tgttggatcg cgtcggatat agcccttttc
    19381 ttctagtcgt gataaatgtc cgtgcactgt agaactagaa gcgaggccga ctgcttgacc
    19441 gatttcacgt acggaaggtg gatatccttt ttcttgtact tttagcttaa taaagtcgag
    19501 aatgtcttgc tggcgtttcg ttaacttttc catgttttct aacacctcgt tttctttcgt
    19561 ttttcttatt aataagtata acatgcgaaa aaacattcta caaacataag ttcgaacaaa
    19621 agggagattt atgatacact agagagaaaa tatagcgaga aagaagggtt caaaatgaat
    19681 gcaattgttt atgcacgtgt gagtacaaca aaagaagcac aagaaacatc gttattgcgt
    19741 caaaaggatg aattattgca tttagctgag cgctatgaaa tgaatgtgac aaaagtgatt
    19801 gaggaacagg ctagtggcta tacaattgaa cgtgatggca tattagaagt attagataca
    19861 attcgagatg aacaagttga tgcacttcta atacaagatg aaacacgtct tggtagaggg
    19921 aatgcgaaga ttgcgttaat gcattgttta cataaagagg gaataaaagt atatacacat
    19981 acgcataatg gtgaattaca attgtcggat tctgattcga tggtattaga tataattagt
    20041 attgttgaag aatatcaaag aaagattcat aacttgaaaa ttaaacgtgg tatgcaacgc
    20101 gcggtagaaa aaggctatcg gccagaaaat aatttgaaaa atcgtcattt aagcgtaggg
    20161 cgagagaaaa aagaagtgcc aattgaggaa attgtacgtt tgcgcaagag tgaactcact
    20221 ttcgaagaaa ttgcggcaac gcttcgtgga tttggtcata atgtttcaaa agcgactgta
    20281 catcgtagat acgtagagta tacaaagcaa ttgcttgata aagaagagta actattgtat
    20341 gataataatc agttttgatt agaaggggga ttcgagatgc ttaatcacga actcgttgaa
    20401 cgcattaact tcttagcgaa aaaagcaaaa gctgaaggtt taactgaaga agaacaacgt
    20461 gagcgtcaat cgctacgaga acaatattta aaaggatttc gtcaaaatat gttaaacgaa
    20521 cttaaaggaa ttaaagtcgt taacgaagaa ggtacagatg ttacaccagc gaaattaaaa
    20581 gctttaaaaa agcaagataa tgcaaaatta aattaaaaga tgggcgaagc ccatcttttt
    20641 tatttgttat ttaataactt tccagttgtt atttctcgtt gcttctattc ttttatgctt
    20701 caatatatag ttagcaataa gttcagacat atctgttgga atatctttta ttactggttt
    20761 attttgaaac atgaagaagt tccctccgcc gtttgctcga taattattca taacaacgtc
    20821 atattcttca tttatatcga gtgtagcgcc tttatactgt aaagactcta ctctttcacc
    20881 aattggtttt gaaatgttta atacatacga aatcccttcc cacatatcgt aattataatg
    20941 cgcaggtttt ggttctatga atgcaggatt aacaattata tctccaactt tatttaatgt
    21001 gaaataagaa gcagaaagtt cgagagcatc ttttatatcg gctccagtca ctcgaataac
    21061 ttttaatgtg tttgggtaaa tataattgga aacgatatcc cgcattgtga catgtttcgg
    21121 gaatcctgga gatgtattat gaaacaaact tgtacaagaa atagaaacgt tagctatatc
    21181 catctggatt ttatttatga attcaataaa aggatggtct tgcaaacgag tttgcatagc
    21241 atctgaaatt cgcatgtctc catgaatgat gccaataggc tgatcaagcc atttttgtgt
    21301 tttctcttca taatcggcga ccaaggaaag aacatctttg tcggcctcga ttccttgcac
    21361 aggcaataat tgtgcgtaac tatttttctt tacccatttt tgttctgttt tttcgaatat
    21421 tacttttacc tttccaacgg agtgtccatt gcatccggtc tgtaaaattg ttacaccatt
    21481 atctaaagtt tgagcaattt ctcggtgttg gtggcctgtt agtaaaatat ctataccatc
    21541 aatttcatca tacattgcgt atccttggtt ttcacctgtt aaaacttcag tcggtactcc
    21601 tgtttgaaaa tcgcgttcaa atcccccgtg ataggctacg actagtaaat cgggctgctc
    21661 atgtttacgg atgtaaggaa cccacttttt tattgtttct aatgcatctt caaatagtaa
    21721 atctttaata tgatgggcct gttcccaatt cgggatgtaa tgtgttgttg cccctaaaat
    21781 agcaattttt atatttgatt caatatgttt tattatatag ggtttcccga aataaggttc
    21841 ttttatgttt ttatctaaaa tgtttgctga taagtacggg aagtttgcag tttctacagc
    21901 atgatttaat atatccattc cataattaaa ttcatgattg ccgataattg cagcatcata
    21961 atttaaatag ttggccaata aggacattgg atttttctta tctttttcgt atgtagcgta
    22021 atgataagtt aaaggtgttc cttgtatgaa atcaccgtta tcaactaaaa gaacgtttgt
    22081 atttttggaa cgttcttttt ttataagagt agaaatttta gctaaaccaa tttctgcttt
    22141 ggagttatct tggtagtgaa ttggatacac agtaccatgt acatcgcttg ttaataaaat
    22201 atttaaagtt acaatttgat tttgattcaa taccattcac cttttctatt gttatctttc
    22261 aattaatcat atcaaatata tgaaaagaat tttaatcaga atgtatagaa tgtgtaaaga
    22321 ttctgtaaat aagtaattgt ttgtaaaaat atgtgatata tttcttcatg tttacggaag
    22381 gttattttat aacaacgaaa aatggaggca ttcacatgtt gaaaaaagtt tttgcaatga
    22441 gcacaacagt tgtactagca gcggggttat taagtggctg tggaacgaag gaatcaagtg
    22501 caagtaaaaa tgaggatacg aaaaaaggtt atgtaccgaa gacgttaaat gttcaatttg
    22561 ttccttctca aaatgcagat acgttagagg caaaagcaaa accattggaa aatctattaa
    22621 gtgataaatt aaacattccg gtaaaagtta gtatttcaac gaattacaat acaattgtag
    22681 aagctatggc atcaaaacaa gtagatgtag gatttttacc tccaacagcg tatgtgttag
    22741 cgcatgagaa aaaggctgca aacgtaatat tacaggcgca acgttttggg gtagatgatg
    22801 aaactggagc tcccacaaag gacttagtag atttttataa atcagagttt gttgttaaga
    22861 aagattctaa tattaacagt gtaaaagaat taaagggtaa aaaaattggt tatcaagatg
    22921 taacatcatc agcagggtat gtatggcctg cagctgtatt gttaaaagag ggagtcgatc
    22981 cgctaaagga tgtgaaacct gttacattaa aaggtcatga tcagtcactt attgctcttt
    23041 taaatggtga tgttgatgca gctgttgtat tccaagatgc tcgtaatatt gtaaaaaaag
    23101 attatccgaa tatattcgat caaacgaaaa tagtaaaatt tacggagaaa attccaaacg
    23161 atacgatttc tgtacgttct gatttagatg cggagtggag caagaaatta caagatgctt
    23221 tcattgaaat aggaaagaat gaagaagggc acaaaatcat taaagaggta tactcacacg
    23281 aaggatatgt gaaatctgat gatagtaaat ttgatatcgt tcgtgactat ggaaagaaag
    23341 tgaaaacaca ataatacata tggaaatggc gactaactgg aaagtgtgtg atttcagtta
    23401 gtttgccgtt tttcagttat tgataataca tagaaggtag gtaagatgtg tgatagagtt
    23461 tcaaaatgtc tccaaagtgt atccaaatgg tacgaaagga ttgaaaaaca taaatttaaa
    23521 aattcaaaaa ggtgaatttg ttgtaatggt cgggctatct ggggctggaa aatctacact
    23581 cctcagatca gtaaatcgcc ttcatgagat tacagaagga gaaattatta ttgaaggtga
    23641 gtctattact gctgcaaaag gcaaagagtt acgacgcatg cgccgagata ttggtatgat
    23701 ttttcaaagc tttaaccttg taaagcgatc cacggtactg aagaatgtat tagccgggcg
    23761 tgttggatat cattcgacat tacgtacaac gttaggcttg tttccgaagg aagatttgga
    23821 acttgcattt caggctttga acagggtaaa tattttagaa aaagcatatg cacgagcaga
    23881 tgaattatca ggaggacaac agcaacgt
//
