LOCUS       NZ_CP040605            21131 bp    DNA     circular CON 25-AUG-2024
DEFINITION  Saccharopolyspora sp. ASAGF58 chromosome, complete genome.
ACCESSION   NZ_CP040605
VERSION     NZ_CP040605.1
KEYWORDS    RefSeq.
SOURCE      Saccharopolyspora sp. ASAGF58
  ORGANISM  Saccharopolyspora sp. ASAGF58
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 8045912)
  AUTHORS   Guo,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-APR-2019) Grain Processing Research Group, Academy of
            National Food and Strategic Reserves Administration, Baiwanzhuang,
            Beijing 100037, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.15x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012277335.1-RS_2024_08_25
            Annotation Date                   :: 08/25/2024 04:20:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,606
            CDSs (total)                      :: 7,535
            Genes (coding)                    :: 7,265
            CDSs (with protein)               :: 7,265
            Genes (RNA)                       :: 71
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 270
            CDSs (without protein)            :: 270
            Pseudo Genes (ambiguous residues) :: 0 of 270
            Pseudo Genes (frameshifted)       :: 80 of 270
            Pseudo Genes (incomplete)         :: 228 of 270
            Pseudo Genes (internal stop)      :: 14 of 270
            Pseudo Genes (multiple problems)  :: 48 of 270
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:54:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4368701
            Orig. end                         :: 4389832
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040605.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21131
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="10"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21131
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21131
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11131](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11131)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(3..842)
                     /locus_tag="FDZ84_RS20935"
                     /old_locus_tag="FDZ84_20975"
     CDS             complement(3..842)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS20935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FDZ84_20975"
                     /product="DUF308 domain-containing protein"
                     /protein_id="WP_168587287.1"
                     /transl_table=11
                     /translation="MTWGPGQQPRQEAQPERKAMSQRLWPISILADVAAVVALLMSSTQ
                     NVAVVIAAIALLLGVVHLWASFGKPVDRWVVLSVAGIVAGAAMIAVVATRSLMAVPDQA
                     SGQATDLPHQTSPTTPNPTTPRPPATTSASQTSSTSVAPAVGRESGDKPIVLTSGYALD
                     LDSAEPLWVAKRTEDSSGHDLENSAGYLYAREDIAVATAQATFEDCVRAGYYSSISSNY
                     LVTGAAFCVKTTTGAYGRIVVRDAQGSQLVLDVVEEAELAQRAAASLCQVSSIASAS"
     gene            1058..>1264
                     /locus_tag="FDZ84_RS39065"
                     /pseudo=""
     CDS             1058..>1264
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013412.5"
                     /locus_tag="FDZ84_RS39065"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSEDEIVDFIAQRRIVVLATLKSDGRPHLVPMWFVHDGPVIEVWS
                     YSRSQKTLNLRRDPRATLLLETGT"
     gene            1535..2980
                     /locus_tag="FDZ84_RS20945"
                     /old_locus_tag="FDZ84_20980"
     CDS             1535..2980
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006239779.1"
                     /locus_tag="FDZ84_RS20945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_20980"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_210435025.1"
                     /transl_table=11
                     /translation="MWDGSPGVKGVAPSAYSGNVNWTVDVPVDDLPELPPLPPEMRARL
                     DDALARSAVQQPQWPDQDQAGKVRKVLESVPPVTVPSEVNQLRQHLAAVARGEAFLLQG
                     GDCAETFADNTEPHIRGNIRTLLQMAVVLTYGASMPVVKVGRIAGQYAKPRSSNTDALG
                     LPSYRGDMINSLAATEQARRHDPSRLIRAYANASAAMNLSRALTSAGMAALTKVHDWNK
                     DFVLNSPAGERYESVAAEIDRGLRFMSACGVDDSSLHAVQFYASHEALVLDYERAMLRL
                     DTSGDQPRLYDLSGHFLWVGERTRQLDGAHIAFAELISNPIGIKIGPGTTPEQAIEYVE
                     RLDPNNEPGRLTLISRMGNGKVRDVLPSIVEKVTASGHQVIWQCDPMHGNTHEASTGYK
                     TRHFDRIVDEVQGFFEVHHRLGTHPGGIHIELTGEDVTECLGGAQEISDADLAGRYETA
                     CDPRLNTQQSLELAFLVAEMLRG"
     misc_feature    1576..1590
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.68"
                     /tool="antismash"
     gene            complement(3056..3751)
                     /locus_tag="FDZ84_RS20950"
                     /old_locus_tag="FDZ84_20985"
     CDS             complement(3056..3751)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165662.1"
                     /locus_tag="FDZ84_RS20950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_20985"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_168587289.1"
                     /transl_table=11
                     /translation="MRTIGMLGGMSWESSAEYYRLLNEESRARLGGYNTVPSVLYSVDF
                     AEIVAMQEAGDWAAAGRHLADAARRVRRAGADLVLLCTNTMHQVAEAIEAAIDVPFVHI
                     VDATGARIAAAGHTRVGLLGTRYTMELDFYRARMRDQHGIDVIVPAEPDRTLVHDVIYQ
                     ELTRNRVEDSSREQYVRVVECLAERGAEAVIFGCTEITLLLGPDDSPLPLFDSTRLHVA
                     HALDIALAK"
     gene            3823..4128
                     /locus_tag="FDZ84_RS20955"
                     /old_locus_tag="FDZ84_20990"
     CDS             3823..4128
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012354.5"
                     /locus_tag="FDZ84_RS20955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_20990"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_246868309.1"
                     /transl_table=11
                     /translation="MRSKRNLGRGRAAVVGFPGDRAGGSLGAAARALGWTRPAVSQHLR
                     RLERQAGTALVLRHSRGVALTEAGQVLARHAEAPRPGRMGSVSAVIHAFREAGDQL"
     gene            complement(4082..5674)
                     /gene="mptB"
                     /locus_tag="FDZ84_RS20960"
                     /old_locus_tag="FDZ84_20995"
     CDS             complement(4082..5674)
                     /codon_start=1
                     /gene="mptB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154547.1"
                     /locus_tag="FDZ84_RS20960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_20995"
                     /product="polyprenol phosphomannose-dependent alpha 1,6
                     mannosyltransferase MptB"
                     /protein_id="WP_246868310.1"
                     /transl_table=11
                     /translation="MPPSVSIESAPDWSERTNNTTADLPSLGGRRPPRRPLPLRTIALG
                     AIGSVLLLIGSFGAGGTLVHDPVLGSGPLSVLRYGHGRDVAVTVVYVGFALLVWAWVRL
                     GRGVIAHLVTSRGVLWATAAWLGPMLIAPPLFTRDVYSYLGQGLLALNGLDPYGVGPSA
                     LTGPIPENVHPTWQTTPAPYGPLFIGVAKGVILLAGHDIIASVIVMRLVLLGGLVMLIC
                     ALPGLVRHLGGRLPVALWLVAASPMTVVHLVGGPHNDMLMIGLLSVGTLLMLEGKNVAG
                     IALVSAAMAIKATAGLALPLLVWIWASRLEGPLWRRFLRAVFPAVGVFVVVFGACTALA
                     KVGFGWLSALSAPGMIVNYLSAPTAVGQALHSLVSLFGETNIWPFVGATRTLGSVLLVA
                     ILAWNWWQARDGGPEAVRRAAIVLCCGALLSPVLLPWYTTWGLALGSAFLWTPRALSYV
                     VGASIALVLAYYPDGEQAMYNWPFVAVGIGAALLGALSLVRFDPLGLSSAFGKLSRTVT
                     TGRPPREMHGSQR"
     misc_feature    5808..5819
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.21"
                     /tool="antismash"
     misc_feature    complement(5809..5829)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.81"
                     /tool="antismash"
     gene            complement(5901..7886)
                     /gene="pknB"
                     /locus_tag="FDZ84_RS20965"
                     /old_locus_tag="FDZ84_21000"
     CDS             complement(5901..7886)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943830.1"
                     /locus_tag="FDZ84_RS20965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21000"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_168587291.1"
                     /sec_met_domain="Pkinase (E-value: 2.4e-44, bitscore:
                     150.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPETRSSGGASLVGATLERRYRVDSLIARGGMSTVYRGLDTRLD
                     RPVAIKVMDAQYSGDRSFVERFEREARAAARLHHPDIVAVYDQGVDHGLAGDHVFLVMQ
                     LVEGCTLRDLIMDRGGRLPVAMALSVMAPVLSALGAAHQAGMVHRDVKPENVLIGTGGS
                     VMVADFGLVRAAAEAGTTSGGVILGTVAYLSPEQVTTGAADARSDVYAAGIVFYEMLTG
                     RPPYVGDTALSVAYRHVNDDVPPPGELVPEIPPAVDDLVFRATRRDPAQRPESAEAFLA
                     ELERVRTELGIAPVAVPVPASEERTRQLTPPVAAGDPPTEQIPAVRDTSVGPQRTRAMA
                     RPATGDHTEEFSTVAAAPSGPERDRRRGRRTVMVWTVVVLVLAALMGGAAYWLGIGSYV
                     QVPRVVGEQEAAAQQALEGTDLTGNVTKEYNNTIAEGVVISSNPGEGSRVRSGGTVDLV
                     VSLGKPKVPQVAEGTTVAEAESAIRNAKLQPKHDESGDQYHTTVPEGRVISVNPAPGTT
                     LNISAEVTLIVSKGPPPVKVPDVRGMSRDDAFTTLRNAGFDPYEAGRQFDSGVDGDHVI
                     STDPAIGSELRLVGQPRIGVVLSNAVQVPSLNGVQVDEAKQQVAALGLQLSVQSFFERP
                     NMVILGQYPLPGSRVEPGTTIHATAF"
     misc_feature    7865..7878
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.49"
                     /tool="antismash"
     gene            8058..8423
                     /locus_tag="FDZ84_RS20970"
                     /old_locus_tag="FDZ84_21005"
     CDS             8058..8423
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657740.1"
                     /locus_tag="FDZ84_RS20970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21005"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_210435026.1"
                     /transl_table=11
                     /translation="MSAIPAAPDVLAPDVEVVPLPDVAERLGQPVTRVHQLIRDGHLLA
                     LRRNGVLGVPTAFLTDTEVVKGLAGTITLLRDNGYREDEILRWLFTPDDSLPGTPIDAL
                     RGDRGREVKRRAQAMGF"
     gene            complement(8538..10001)
                     /gene="crtI"
                     /locus_tag="FDZ84_RS20975"
                     /old_locus_tag="FDZ84_21010"
     CDS             complement(8538..10001)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943825.1"
                     /locus_tag="FDZ84_RS20975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21010"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_168587292.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.1e-07, bitscore:
                     28.7, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.2e-15, bitscore: 56.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVSGRTDHVVVVGAGLAGLSAALHLAGAGRRVTVVERAGLPGG
                     RAGLHELAGYRIDTGPTVLTMPELVDEALGAVGESLSERLDLIPLHPAYQARFADGSTL
                     DVHTDAAAMEEEVRRFAGPAEAAGYRRLRRWLTEVYRAEMHRFIDANFDSPLGLLSPEL
                     ARLATLGGFGRLGPAIGRFLSDQRLRRVFSFQALYAGLDPRRALALYAVISYMDTVNGV
                     WFPRGGMHEVPTALADAAAGAGVEFRYNAEVTELERRGDRIAAVRTSDGARIAADAFVL
                     TPDLPVVHELLDHRTRRRLRWSPSAVVLHAGTARGWSGAHHTISFGAAWHGTFTEIIRD
                     GRLMTDPSLLITRPTATDPSLAPDGRELHYVLAPCPNLRTGPIDWDRVGPAYRDELLST
                     LERRGFTGFGAAIEAQQLVTPADWAAQGHAAGTPFSAAHTFAQTGPFRPRNLVRGLANA
                     VLAGSGTTPGVGVPPVLLSGKLAAQRITG"
     gene            complement(10001..11131)
                     /locus_tag="FDZ84_RS20980"
                     /old_locus_tag="FDZ84_21015"
     CDS             complement(10001..11131)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010231352.1"
                     /locus_tag="FDZ84_RS20980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21015"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_246868311.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4e-46, bitscore:
                     156.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSNSTAVQATGKEDVAVELDLPGQVQHTLTEYLQTRRAEAVGL
                     DPAFAAAVAELSGFVLGGGKRIRPTFAWWGWRAAGGPAEGPPAQAMLRAASALELLQAC
                     ALVHDDLIDESDTRRGNPTVHRRFEQIHRESGFSGGATQFGLAAAVLLGDLALSWADDM
                     LHSAGIAPQALVRALRPWRAMRTEVLAGQYLDVLGQFRGDETPQAALQICQLKAASYTV
                     QRPLELGAEIAGAGPDALQALRRFGSDIGVAFQLRDDLLGVFGDPEVTGKPAGDDLREG
                     KRTVLIAEAVAAARGQADQPALDLLRDVLGDPELDADRVEQARQVLTRLGAVEAVEKRI
                     TDLTGSAMLALHTAGLAEPAASRLAELAIAVTDRSH"
     gene            11365..12234
                     /locus_tag="FDZ84_RS20985"
                     /old_locus_tag="FDZ84_21020"
     CDS             11365..12234
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332694.1"
                     /locus_tag="FDZ84_RS20985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21020"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_168590229.1"
                     /transl_table=11
                     /translation="MTAVVDRLNTEKTTFSVEFFPPRSDDEERILWRAVRELEPLDPAF
                     VSVTYGAGGSSRDRTIRTTGRIAQETTLTPMAHLTAVDHSVAELRNVIGWYAASGVQNV
                     LAVRGDPQGDPNGEWRQHPEGLTYAEELVRLVRELGEFCVGVAAFPHGHPRSTDLDVDA
                     DHLVRKIRAGAGFAIAQLFLEPEYFLRLRDRMVARGCDVPLLPGVMPITTPRVLGKFGE
                     LAGVPVPAEVSEQLWPLAEDPAGFRAAGVDLVTRLCERLIAEGVPALHFYTLNRSKATR
                     QVVANLGL"
     misc_feature    complement(11400..11411)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.29"
                     /tool="antismash"
     gene            complement(12238..12906)
                     /locus_tag="FDZ84_RS20990"
                     /old_locus_tag="FDZ84_21025"
     CDS             complement(12238..12906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010695252.1"
                     /locus_tag="FDZ84_RS20990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21025"
                     /product="DUF3153 domain-containing protein"
                     /protein_id="WP_168587293.1"
                     /transl_table=11
                     /translation="MDAKTPRGRAALLTVLIGVLGTLLSGCLHVNAALNISGEDLVSGE
                     VRLSTQIADGQAPFRLQPPENLADRVQVTPNDDGGRTGSHLSFHDLTFPEVEQLAEALS
                     PTDSRYRLHLSRSGSLVFFEGSADLTPLADTDSGADLKISAPGEITNTNGQESAGTVTW
                     SLQPGSVTELSATYQFSNSAGMDWIGWALLVGALTFGAAIVVALLALRTHIRTRAEQNA
                     "
     misc_feature    complement(13011..13025)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.2"
                     /tool="antismash"
     misc_feature    complement(13020..13034)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.16"
                     /tool="antismash"
     misc_feature    13041..13055
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.14"
                     /tool="antismash"
     misc_feature    13050..13064
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.2"
                     /tool="antismash"
     misc_feature    complement(13090..13106)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.17"
                     /tool="antismash"
     gene            13160..14839
                     /locus_tag="FDZ84_RS20995"
                     /old_locus_tag="FDZ84_21030"
     CDS             13160..14839
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943816.1"
                     /locus_tag="FDZ84_RS20995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21030"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_168590230.1"
                     /transl_table=11
                     /translation="MGVDHNGVHEISDRFVTELVSLDPVAGTYLGVPDREEELTDYSPD
                     GYRARAELARRSLAAVQAAEPADDSERIAQAVFAERIGLDLELHEAGADMAALNVIASP
                     VQGLRQVFDLMPTDTPEQWSTIARRLSVMPEAVLGVRAGLLAAAADGNVSAVRQVSKVA
                     EQCDTWSGRDGQSFFAAMVARAEGVDESLCRDLDSAAGSAAEAFAGLADFLRGELLPKA
                     PEKDAVGEQRYRLWSRYFTGARLDLQEAYEWGWQEFAGIEAEMKQIANRIRPGASLAEA
                     AAVLDADPRYQVHGQDRFEAWMQRLSDQALQDLRGTHFEIPDPLMRLECKIAPPGGGVG
                     AYYTGPTDDFSRPGRMWWSVPADRQDFPTWREVSTVYHEGVPGHHLQVATAVHEAQRLN
                     KFQRLACFVSGHGEGWALYAERLMRELGYLEDDGDLLGMLNDQLFRAARVVVDIGMHLE
                     LEIPAGTGFHEGERWTPELGLEFMLSRTITDPAQVRDEIDRYLGWPGQAPSYKLGERLW
                     RAARDEARQRHGAAFDMKEFHTQALKMGGMGLDTLREQLALL"
     gene            complement(15075..15644)
                     /locus_tag="FDZ84_RS21000"
                     /old_locus_tag="FDZ84_21035"
     CDS             complement(15075..15644)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943815.1"
                     /locus_tag="FDZ84_RS21000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21035"
                     /product="N-acetyltransferase"
                     /protein_id="WP_168587294.1"
                     /transl_table=11
                     /translation="MTAAPSPSFDRITELTTDQLRARLPEALQIYVTAMNYPPATAQQR
                     APMWSAHMLRAGWRCVGAFNDRDELVGLGYGYLGAPGQWWHEQVRRGLLSSGGDAEAWL
                     DDYFELTELHVYPGSQGVGLGEEVLRRLLAGAQGSKVLLSTPEGPTRAWRLYRRVGFGD
                     VLRDYRFTGDPRPFAVLGRSLPLEPR"
     misc_feature    15827..15842
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 24.07"
                     /tool="antismash"
     misc_feature    complement(15828..15841)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            15842..16405
                     /locus_tag="FDZ84_RS21005"
                     /old_locus_tag="FDZ84_21040"
     CDS             15842..16405
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037499.5"
                     /locus_tag="FDZ84_RS21005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21040"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_246868312.1"
                     /transl_table=11
                     /translation="MNSSSGIESGGGVGEAPRRRTCRLPAAGVDGFVVQRRLPMSFSTD
                     LSIPAPRRSVENHEPTPEAETPAGSLSLLLNARTCLHEAEEADRPGERYVAAHVAALRA
                     ATAVVVARSWRRENGRPASAWTLLTGAAPELREWAAYFAARSDRRAAAEAGVPTITWLD
                     ADGLLARSREFLDIVGRSLLGVAR"
     misc_feature    16145..16147
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16402..17172
                     /locus_tag="FDZ84_RS21010"
                     /old_locus_tag="FDZ84_21045"
     CDS             16402..17172
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010695247.1"
                     /locus_tag="FDZ84_RS21010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_21045"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_246868313.1"
                     /transl_table=11
                     /translation="MNGTEVRLDYGRMLDLLGIEAQLLTAATHDAHVHAPVWGASGRTL
                     GQTVRHLGDLCEDTLSWLGSSAVERRWDLPDQPELREVTGRFAVRLADLLAELGARPPH
                     DPCPTWWPEQHTVRFWLRRMLHATTVHRVDVQAAAGVLPTPIEPDVATDGIDEVLRLWF
                     GYRLHALGITATRACSVGVYVEGRNWLVTADQNGTAVVSSDDVSTATPDAVVGGDAPAV
                     YLWMWGRLPDRAVETSGDLDAIAQLWGLLQLATR"
     misc_feature    17656..17670
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 ggctacgacg cggacgcgat cgaggaaacc tggcagaggg aagccgcggc gcgctgagct
       61 agctcggctt cttccacgac gtccagcact agctgcgagc cctgggcatc gcggacgacg
      121 atccgcccgt aggcgccggt ggtcgtcttc acgcagaacg cggcgccggt gacgaggtag
      181 ttgctgctga tcgagctgta gtagccggcc cgcacgcagt cctcgaaggt cgcctgggcg
      241 gtggccaccg cgatgtcctc gcgcgcgtag aggtagccag cgctgttttc gaggtcgtgc
      301 ccggaagagt cctccgtccg cttggcgacc caaagcggtt cggcggaatc cagatccagg
      361 gcgtagccac tggtcagcac gatcggcttg tcgccgctct cgcggccgac cgcaggggcg
      421 acggaggtgg agctggtctg cgatgccgag gtggtggccg gcggccgcgg tgtggtcggg
      481 ttgggcgtgg tcgggctggt ctgatgcggc agatcggtcg cctggccgct cgcctgatcg
      541 ggcaccgcca ttagtgatcg ggtggccacc acggcgatca tggctgcccc tgccacgatc
      601 ccggcgaccg acagcaccac ccaccggtcg acgggtttgc cgaagctcgc ccacagatgc
      661 accacgccca gcagcagtgc gatcgcggcg atgaccacgg cgacgttctg cgtcgagctc
      721 atcagcaacg cgaccaccgc ggcgacgtcg gcgaggatgc tgatcggcca caaccgctgc
      781 gacatcgcct tgcgctccgg ctgcgcttcc tgccgtggtt gctgacccgg tccccacgtc
      841 accggccgct cctctcgcgt cgtcgacggg gcgagagcct agcgccagag gtgtcgcgtc
      901 agggccggtt tgcgatggtc gaggccgatt cggatgatct tcccgggcgg cggcctcggg
      961 gtctgcgttg acgcggtggg gtctcccgga acaagatcga cgcaccatcg gcgtagcgga
     1021 acccggagca cgcatgtcgc gacgcggcca gatcaccatg tccgaggacg agatcgtcga
     1081 cttcatcgcc cagcgccgga tcgtggtgct ggcgacgctg aagagcgacg ggcggccaca
     1141 tctggtgccg atgtggttcg tgcacgatgg ccccgtgatc gaggtgtggt cctacagccg
     1201 gtcgcagaag acgctgaacc tgcgccggga cccgcgggcc acgctgctac tggagaccgg
     1261 cacggagtac ggcgagctgc gcggcgtctc gctggagtgc ggcgcggaga tcctggaggc
     1321 cccagcggac gtcgagcgca tcggcattgg cctggccgag cgctacggcg gggcggcccc
     1381 gagcggtctt gcggcgagcg aggaagctcg ggaggccctg cgcaccaagg cggcgaagcg
     1441 cgtcgggctg cgcttgaccc gacgcggacg atcacctggg accaccgcaa actcggcggt
     1501 gcgtactgaa tcgaagcccg ctgggcgatc cgctatgtgg gacggctctc ccggagttaa
     1561 aggggtagcg cccagtgctt attctgggaa cgtgaactgg accgtcgacg tccccgtaga
     1621 tgacctgccc gagctgccac cgctgccgcc ggagatgcgc gcccgcctcg acgacgcgct
     1681 ggcccgttcc gccgtgcagc agccgcagtg gccggaccag gaccaggccg gcaaagtccg
     1741 gaaggtgctg gagagcgtgc cgccggtgac cgttccctcc gaggtgaacc agctgcgtca
     1801 gcacctcgcc gcggtcgcca ggggcgaggc ctttttgctg cagggcgggg attgcgcgga
     1861 gacgtttgcg gacaacaccg agccgcacat ccgcggcaac atccgcacgc tgctgcagat
     1921 ggcggtggtg ctgacctacg gcgcgagcat gccggtggtc aaggtcggcc ggatcgccgg
     1981 gcagtacgcc aagccgcggt ccagcaacac cgacgcgctg ggcctgccgt cctaccgcgg
     2041 cgacatgatc aactcgctgg ccgccaccga gcaggcacgc cgccacgacc cgtcgcggct
     2101 gatccgcgcc tacgccaacg ccagcgccgc gatgaacctc tcccgcgcgc tgaccagcgc
     2161 cgggatggcc gcgttgacca aggtgcacga ctggaacaag gacttcgtgc tcaactcgcc
     2221 ggccggtgag cgctacgagt cggtcgccgc cgagatcgac cgcggcctgc gcttcatgtc
     2281 cgcctgcggc gtcgacgact ccagcctgca cgcggtgcag ttctacgcca gccacgaggc
     2341 gctggtgctg gactacgagc gcgccatgct ccggctggac acctccggcg accagccgcg
     2401 gctgtacgac ctgtccgggc acttcctgtg ggtgggggag cggacccgcc agttggacgg
     2461 cgcgcacatc gcgttcgccg agctgatctc caatccgatc ggcatcaaga ttggcccggg
     2521 caccacgccc gagcaggcca tcgagtacgt cgagcggctg gacccgaaca acgagcccgg
     2581 ccggctcacc ctgatcagcc ggatgggcaa cggcaaggtg cgcgacgtgc tgccgtcgat
     2641 cgtggagaag gtcaccgcct ccgggcacca ggtgatctgg cagtgcgacc ccatgcacgg
     2701 caacacccac gaggccagca ccggctacaa gacccggcac ttcgaccgga tcgtggacga
     2761 ggtgcagggc ttcttcgagg tgcaccaccg gctcggcacg cacccgggcg gtatccacat
     2821 cgagctgacc ggcgaggacg tcacggagtg cctcggcggc gcccaggaga tctccgacgc
     2881 cgatctggcg gggcgctacg agacggcctg cgacccgcgc ctgaacaccc agcagtcgct
     2941 ggagttggcc ttcctggtcg cggagatgct gcgcggctga accagcagga cgcacgcggg
     3001 agggcccgga accaaagcgg ttccgggccc tccacgtttc gcgcagcccg attcgtcact
     3061 tggcgagggc gatgtcgagg gcgtgcgcga cgtgcaggcg ggtggaatcg aacagcggca
     3121 gcgggctgtc gtccggtccg agcagcaggg tgatctcggt gcagccgaag atcacggcct
     3181 cggcgccgcg ctcggccagg cactccacga cgcgcacgta ctgctcgcgg gagctgtcct
     3241 cgacgcggtt gcgggtcagc tcctggtaga tgacgtcgtg caccagggtg cggtcgggtt
     3301 ccgccgggac gatcacgtcg atgccgtgct ggtcgcgcat ccgcgcccgg tagaagtcga
     3361 gttccatggt gtagcgggtg cccaacaggc cgacccgggt gtgaccggcg gccgcgatcc
     3421 gtgcgccggt ggcgtcgacg atgtgcacga acggcacgtc gatcgctgcc tcgatcgctt
     3481 cggcgacctg gtgcatcgtg ttggtgcaga gcaggaccag atccgctccg gcgcgtcgca
     3541 cccgccgcgc ggcgtcggcc aagtgccggc ccgccgctgc ccagtccccg gcctcctgca
     3601 tggccacgat ctcggcgaaa tccacgctgt acagcacgct cggcacggtg ttgtacccgc
     3661 ccagccgagc gcggctctcc tcgttcagca gccggtagta ctcggcggag gattcccagc
     3721 tcatcccccc gagcatcccg atcgtgcgca tgcgcctcct cgtcgaacga cctcgtgccc
     3781 gacagcctca cccgcggccg caggttagcc ggatcttgct tggtgcggtc caagcgaaac
     3841 ttggggcgtg gacgcgcagc ggttgttggt tttccgggag atcgtgcagg cggctcgctc
     3901 ggtgcggcgg cacgggcgct gggctggacc cgacccgccg tcagccagca cttgcggcgg
     3961 ctggaacgcc aggcgggcac cgcgctggtc ctgcgtcatt cgcgcggcgt tgcgctgacc
     4021 gaagccgggc aggtgcttgc caggcatgcc gaagcaccgc gacctggccg gatgggttcg
     4081 gtcagcgctg tgatccatgc atttcgcgag gcgggcgacc agttgtgacc gtgcgcgaca
     4141 gcttgccgaa ggcgctgctc agacccagcg ggtcgaagcg gaccagcgac agcgcgccga
     4201 gcagggcggc gccgatcccg accgcgacga acggccagtt gtacatcgcc tgctcgccat
     4261 cggggtagta ggccagcacc agcgcgatcg aggcgccgac cacgtaggac agcgcccgcg
     4321 gagtccatag gaaggcgctg cccagggcca agccccaggt cgtgtaccac ggcagcagga
     4381 ccggcgacag gagcgcgccg cagcacagca cgatggccgc ccggcgcacc gcctcgggcc
     4441 cgccgtcgcg ggcctgccac cagttccagg cgaggatcgc caccaagagc accgagccga
     4501 gcgtgcgcgt ggcgcccacg aaaggccaga tgttggtctc gccgaacagc gacaccaggc
     4561 tgtgcagcgc ctgccccacg gcggtcggcg cggacagata gttgacgatc atgccgggcg
     4621 cggacagcgc ggaaagccag ccgaaaccga ccttggcgag cgccgtgcaa gcgccgaaga
     4681 ccaccacgaa cacgcctacc gccgggaaca cggcgcggag gaagcgtcgc cacagcggcc
     4741 cctccagccg ggatgcccag atccacacca ggagcggcag ggcgagcccg gcggtcgcct
     4801 tgatggccat cgccgccgac accagcgcga tcccggcgac gttcttgcct tcaagcatca
     4861 gcagcgtgcc gaccgacagc agcccgatca tcagcatgtc gttgtgcggg ccgccgacca
     4921 ggtgcaccac cgtcatcggg ctggccgcga ccagccagag cgcgaccggc agccgcccgc
     4981 cgaggtgccg gaccaggccc gggagggcgc agatcagcat caccaggccg cccagcagca
     5041 ccagccgcat cacgatgacg ctggcgatga tgtcgtgccc ggccagcagg atcacgccct
     5101 tggcgacgcc gatgaacagc ggaccgtacg gggcgggcgt ggtctgccag gtcgggtgca
     5161 cgttctccgg gatcgggccg gtcagcgcgg acgggccgac gccgtagggg tcgaggccgt
     5221 tcagcgccag caggccctgg cccaggtagc tgtagacgtc gcgggtgaac agcggcggcg
     5281 cgatgagcat cgggccaagc caggcggcgg tcgcccacag cacgccgcgg gaggtcacca
     5341 ggtgcgcgat caccccgcga cccagccgca cccacgccca cacgagtagt gcgaagccga
     5401 cgtagacgac cgtcaccgcc acatcgcgac cgtggccgta gcgcagcacc gacagcggcc
     5461 cggaaccgag gacggggtcg tggacgagcg tcccgccggc gccgaaggag ccgatcagca
     5521 gcagcacgga cccgatcgcg cccaatgcga tggtgcgcaa gggcagcgga cgacgaggtg
     5581 gccgacgtcc gccgagactg ggcaggtcgg ctgtggtgtt gttggtccgt tcggaccagt
     5641 cgggggccga ctcgatcgaa acactcgggg gcattgtgct cccaatagtt ccacaatcgt
     5701 ccgtccgagc cgccgtgacc aggtcagatc ggtcctgtcg tggccttcgg tcgcgctttt
     5761 cggtgacggc cgcccgtcga gtccccgctg gtagaccctg gcagggcgaa aacgttacag
     5821 cgacgagaag agatcaggat cacattgcgc gtcgttcatt tctggccggt cggcgggtgc
     5881 gcgcacccgc gaaccggtgc tcagaaagcg gtcgcgtgga tcgtcgtacc gggctcgacc
     5941 cggctgccgg gaagcgggta ctggcccaag atcaccatgt tcggccgctc gaagaacgac
     6001 tgcacgctca gctgcagtcc cagcgcggcg acctgctgct tcgcctcgtc cacctgaaca
     6061 ccgttgaggc tgggcacctg gaccgcgttg gacagcacca cgccgatccg cggctggccg
     6121 accagccgga gttcgctgcc gatggccgga tcggtgctga tgacgtggtc gccgtcgacg
     6181 ccggagtcga actggcgccc cgcctcgtag gggtcgaagc cggcgttgcg cagcgtggtg
     6241 aaggcgtcgt cccggctcat cccgcgcacg tcgggcacct tcaccggggg cgggcccttg
     6301 ctgacgatca gggtgacctc ggcgctgatg ttcagtgtgg tgccgggggc ggggttgaca
     6361 ctgatgaccc ggccttcggg caccgtggtg tggtattggt cgccagactc gtcgtgcttg
     6421 ggctgcagct tggcgttgcg gatcgcgctc tccgcctcgg caaccgtggt gccctcggcg
     6481 acctgcggaa ccttgggctt gcccagcgag acgacgagat ccacggttcc gccgctgcgc
     6541 acccgggagc cctcgcccgg gttggagctg atcaccacgc cttcggcgat ggtgttgttg
     6601 tactccttgg tgacgttgcc ggtcagatcc gtgccctcca gcgcctgctg cgccgctgcc
     6661 tcctgctcgc cgacgacgcg cggcacctgc acgtagctgc cgatgcccag ccagtacgcc
     6721 gcgcccccca tcagcgcggc cagcaccagg accacgacgg tccacaccat gaccgtccgc
     6781 ctgccgcggc ggcgatcccg ctccggcccg ctgggcgcag cggcgacggt ggagaactcc
     6841 tcggtgtggt cgccggtggc ggggcgcgcc atcgcacggg tgcgctgcgg gccgacggac
     6901 gtgtcgcgga cggccgggat ctgctcggtc ggcggatctc cggccgcgac cggcggcgtc
     6961 agctgcctgg tgcgctcctc ggacgccggg accggcacgg ccaccggggc gatgccgagt
     7021 tcggtgcgca cccgctccag ctcggcgagg aacgcctcgg cgctctccgg gcgctgcgcc
     7081 gggtcgcgcc gcgtggcgcg gaagacgagg tcgtcgacgg ccggtgggat ctccgggacc
     7141 agctcgcccg gcggcgggac gtcgtcgttg acgtgccggt acgccaccga aagcgcggtg
     7201 tcgccgacgt agggcgggcg gccggtcagc atctcgtaga acacgatccc ggcggcgtag
     7261 acgtcggagc gagcgtcggc ggccccggtg gtcacctgct ccggcgacag gtacgcgacg
     7321 gtgcccagga tgacgccgcc gctggtcgtg cccgcctcgg ccgcagccct aaccagaccg
     7381 aagtcggcga ccatgaccga gccgccggtg ccgatcagca cgttctccgg cttgacgtcg
     7441 cggtgcacca tgccggcctg gtgcgcggcg cccagcgcag agagcaccgg cgccatgacg
     7501 ctcagcgcca tcgccaccgg caggcggcca ccccggtcca taatcagatc gcgcagcgtg
     7561 cagccctcga cgagctgcat caccaggaac acgtggtcgc cggctaggcc gtggtccacg
     7621 ccctggtcgt agacggcgac gatgtcgggg tggtgcagcc gggccgccgc acgcgcctcg
     7681 cgctcgaagc gctcgacgaa cgagcggtcg ccggagtact gggcgtccat caccttgatg
     7741 gccaccggcc ggtccagccg ggtgtccagg ccgcggtaga ccgtggacat gccgccgcgg
     7801 gcgatcagcg aatcgacccg gtaacggcgt tcgagcgtgg ctccgacgag gctcgcgccg
     7861 ccgctggagc gtgtctcagg agtcatcttc cgccaaccgc cgggtaacct ttccaacccg
     7921 attgtggcag gccgcgcggg cggtccgggg aacacctccg cactcggatg tgggaacgat
     7981 cacgatcttg atcgtaggtc gacgataatt cgtgcggtgc acggcatcgc ggtcggtcat
     8041 gtggcaaggt gtgcagcgtg agtgcgatcc ctgctgcccc ggatgtgctc gctcccgatg
     8101 tggaggttgt cccgctgccc gacgtcgccg agcggctcgg tcagcccgtg acccgggtgc
     8161 accaactgat ccgagatggc catctgctcg ctctgcgcag gaacggcgta ctgggcgtgc
     8221 ccaccgcgtt cctcaccgac accgaagtgg tgaagggtct ggcgggcact atcacgctgc
     8281 tccgggacaa cggctaccgg gaggacgaga tcctgcggtg gctgttcacc ccggacgact
     8341 cgctgcccgg aacgccgatc gacgccctgc gcggcgaccg cggccgggaa gtgaagcggc
     8401 gggcccaggc gatgggcttc tgaggccatc ggaagggttc gggaggcccg gcgagtcgcg
     8461 agcgcagccg ggccagtacc cgtgagtgct tctgggggct atggcgccca gaagtactca
     8521 cgagctttga gcatcggtca gccggtgatg cgttgtgcgg cgagcttgcc ggacaacaag
     8581 accggcggaa ccccgacgcc gggtgtcgtg ccggagccgg cgagcacggc gttggccagg
     8641 ccgcgcacca ggttccgcgg ccggaacggc cctgtctgcg cgaaggtgtg cgcggctgag
     8701 aacggcgttc ctgctgcgtg cccctgggcc gcccagtccg ccggggtgac cagttgctgc
     8761 gcctcgatcg cggcaccgaa gccggtgaag ccgcgccgtt ccagcgtgct cagcagctcg
     8821 tcgcggtagg ccgggccgac ccggtcccag tcgatcggcc ccgtgcgcag gttcgggcac
     8881 ggagcgagca catagtgcag ctcgcggccg tcgggtgcca gcgacggatc ggtcgcggtc
     8941 gggcgggtga tcagcagcga tgggtcggtc atcagcctgc cgtcacggat gatctcggtg
     9001 aacgtgccgt gccaggccgc gccgaaggag atcgtgtggt gggcgccgga ccagccgcgg
     9061 gcggtcccgg cgtgcagcac caccgccgac ggtgaccagc gcaaccgccg tcgcgtgcgg
     9121 tggtccagga gctcgtgcac gaccggcagg tcgggtgtga gcacgaacgc atcggccgcg
     9181 atgcgggcac cgtctgacgt gcgcaccgcg gcgatccgat cgccccgccg ctccaactcg
     9241 gtcacctcgg cgttgtagcg gaactcgacg cccgcgcccg ccgccgcatc ggcgagcgcg
     9301 gtcgggacct catgcatgcc gccgcgcggg aaccacacgc cgttgacggt gtccatgtac
     9361 gagatgaccg cgtacagggc gagcgcgcgg cgcgggtcca gtcccgcgta gagggcctgg
     9421 aaggagaaga cccggcgcag ccgctggtcc gacaggaacc ggccgatcgc cgggccgagc
     9481 cgaccgaaac cgccgagcgt cgcgagacgc gccagctccg gcgacagcag gcccagcggc
     9541 gagtcgaagt tcgcgtcgat gaagcggtgc atctccgccc ggtacacctc ggtcagccag
     9601 cgccgcagcc gccggtaccc ggccgcctcc gcgggcccgg cgaaccgccg cacctcctcc
     9661 tccatcgcgg cggcgtcggt gtgcacgtcg agcgtcgagc cgtcggcgaa ccgtgcctgg
     9721 taggccggat gcagcgggat gaggtcgagg cgctcggaca acgattcgcc gaccgcgccc
     9781 aaggcttcgt cgaccagctc aggcatggtc aacacggtcg ggccggtgtc gatccggtac
     9841 ccggcgagct cgtgcaatcc ggcccgcccg ccgggcagtc cggcgcgttc gacgaccgtc
     9901 acgcgccgcc cggcgcccgc caggtgcagg gccgccgaca acccggccag cccagcgccg
     9961 acgaccacga catgatcggt ccggccggat accgtgcgca tcagtggctg cggtcggtga
    10021 ccgcgatcgc cagctctgcc agccgggacg cggccggttc ggccaaccca gcggtgtgca
    10081 gcgcgagcat cgccgacccg gtcagatcgg tgatccgctt ctccacggcc tcgaccgcgc
    10141 cgagccgggt gagcacttgt cgtgcctgct cgacgcggtc tgcgtccagc tcggggtcgc
    10201 cgagcacgtc gcgcagcagg tccagcgcgg gctggtcggc ctgcccgcgg gccgccgcca
    10261 cggcctcggc gatcagcact gtccgcttgc cctcgcgcag gtcgtccccg gcgggcttgc
    10321 cggtcacctc cgggtcgccg aagacgccga gcaggtcgtc gcggagctgg aaggcgacac
    10381 cgatgtcgga accgaagcgg cgcagcgcct gcagcgcgtc cgggcctgcg ccggcgatct
    10441 ccgcgcccag ctccagcggc cgctgcacgg tgtaggaagc ggcttttagc tggcagatct
    10501 gcaacgcagc ctgcggcgtc tcgtcgccgc ggaactggcc gagcacgtcg aggtactggc
    10561 cggcgagcac ctcggtgcgc atcgcgcgcc acgggcgcag cgcgcggacc agcgcctgcg
    10621 gcgcgatccc ggcgctgtgc agcatgtcgt cggcccagga cagcgcgagg tccccgagca
    10681 gcaccgcggc ggccagcccg aactgggtgg caccaccgga gaacccggac tcgcggtgga
    10741 tctgctcgaa cctgcggtgc accgtcgggt tgccccgccg ggtgtccgac tcgtcgatca
    10801 ggtcgtcgtg caccagcgcg caggcctgca gcagctccag cgcgctcgcg gcccgcagca
    10861 tcgcctgcgc cggcggcccc tcggccggtc cgccggccgc ccgccatccc caccaggcga
    10921 aggtcgggcg gatccgcttt ccgccgccga ggacgaaccc ggagagctcg gccaccgcag
    10981 ccgcgaacgc cgggtcgagg ccgactgcct cggcgcggcg ggtctgcagg tattcggtca
    11041 gcgtgtgctg gacctgaccc gggaggtcga gttccacggc gacgtcttcc ttgccggttg
    11101 cttgcacagc ggtcgaattc gatgggggca cacctccatc ctccgcgatg ccgccgagtg
    11161 gtgacggccg ggtccgaagg ggtgctcgga gtcaccaggt tgactccgga acgtagccgg
    11221 atgtctttgc ggtgccctct tcgagcattg cagcgtgcgc ccccgcaacc ggatgtgcgc
    11281 gaatcggcgt cggctcatgc gcgggctgct tgctcgaacc gccatgtggg accggtcgtg
    11341 gggcggttca ctatcctgtt cggcatgacg gcggtggtgg atcggttgaa caccgagaag
    11401 acaacttttt cggtggagtt cttcccgccg cgcagcgatg acgaggaacg catcctctgg
    11461 cgggcggtcc gggagctgga accgctggac ccagcgttcg tctcggtgac ctacggcgct
    11521 ggcggatcca gccgggaccg caccatccgc accaccggtc gcatcgcgca ggagaccacg
    11581 ctgacgccga tggcgcacct gaccgccgtg gaccactcgg tcgccgaact gcgcaacgtc
    11641 atcggctggt acgcggcatc tggggtgcag aatgtgctgg ccgtgcgcgg cgacccgcag
    11701 ggcgacccga acggcgaatg gcgccagcac cccgaggggc tgacctacgc cgaggagctc
    11761 gtccggctgg tccgggagct cggcgagttc tgcgtcggcg tggcggcctt cccgcacggc
    11821 cacccgcgtt ccaccgacct ggacgtcgac gcggaccacc tggtgcgcaa gatccgggcc
    11881 ggtgccgggt tcgccatcgc ccagctgttc ctggagccgg agtacttcct gcggctgcgc
    11941 gatcggatgg tcgcccgcgg ctgcgacgtg ccgctgctgc cgggcgtcat gccgatcacc
    12001 accccgcggg tgctgggaaa gttcggcgag ctcgccgggg tgccggtgcc tgcggaggtg
    12061 tcggagcagc tgtggccgct ggcggaggac ccggcggggt tccgcgcagc gggcgtggac
    12121 ctggtgaccc ggttgtgcga gcggctgatc gccgaaggcg tgcccgcgct gcacttctac
    12181 accctcaacc gctcgaaggc gacgcgccag gtggtggcca acctcggtct ctgaggctca
    12241 ggcgttctgc tccgcccggg tgcggatgtg ggtgcgtagc gcgagcagcg ccacgacgat
    12301 tgcggcgccg aaggtgagcg cgccgaccag cagcgcccag ccgatccagt ccatgccagc
    12361 ggagttggag aactggtagg tggccgacag ctcggtgacc gagccgggct gcagcgacca
    12421 ggtgaccgtg ccagcgcttt cctggccgtt ggtgttggtg atctcgccgg gtgcgctgat
    12481 cttcaggtcg gcgccggagt cggtgtcggc cagcggggtc aggtccgccg aaccctcgaa
    12541 gaacaccagc gagccggatc gggacaggtg cagccggtac cgggagtcgg tggggctcag
    12601 cgcctcggcg agctgctcga cctcggggaa ggtcaggtcg tggaacgaca ggtgcgagcc
    12661 ggtccgcccg ccgtcgtcgt tcggcgtgac ctgcacccgg tcggcgaggt tctcgggcgg
    12721 ctgcaaccgg aacggggcct ggccgtcggc gatctgggtg gacagccgga cctcgccgga
    12781 caccaggtcc tcgccggaga tgttcagcgc ggcgttgacg tgcaggcacc cgctgagcag
    12841 cgtgccgagc acgccgatca ggaccgtcag gagcgcggcg cggccgcgcg gcgtcttggc
    12901 gtccactcgg gcgatcttcc cacccgcacc acgtttccgc tgccccgcga acttgatagg
    12961 gtgcgcagcc gtcccaacac cgcgtgcgga tggccagccg ggtgtgacgc aatttcgcga
    13021 gaaattgacg ttcacccggg tgacggtcaa tttctcgcga aattgcaccc cgccccggct
    13081 gagcggggct gccccatttt tgcggatctg gcttcgccgc ggggcgtgtg agtcgttggt
    13141 gcgcgatagc gtggcgggca tgggagttga ccacaacggc gtgcacgaga tcagcgaccg
    13201 gttcgtcacc gagctggtct cgctcgatcc ggtcgccgga acctacctgg gcgtacccga
    13261 tcgggaagaa gaacttaccg actactcgcc ggacgggtac cgggcccgcg cggaactcgc
    13321 ccgccgcagt ctggccgcgg tgcaggcggc tgagccggcc gatgactcgg agcggatcgc
    13381 gcaagcggtg ttcgccgagc ggatcggcct ggacctggag ctgcacgagg ccggcgcgga
    13441 catggcggcg ctgaacgtga tcgccagccc ggtgcaggga ctccggcagg tcttcgacct
    13501 gatgccgacc gacaccccgg agcagtggag cacgatcgcc cgccgcctgt cggtgatgcc
    13561 cgaagcggtg ctgggcgtgc gtgccgggct gctggcggcg gccgccgacg gcaacgtttc
    13621 ggcggtccgg caggtcagca aggtcgcgga gcagtgcgac acctggtccg ggcgcgacgg
    13681 gcagtcgttc ttcgcggcga tggtcgcgcg ggccgaaggc gtggacgagt cgctgtgccg
    13741 tgacctcgac tccgcggccg gatcggccgc cgaagccttc gccgggctgg ccgacttctt
    13801 gcgcggcgag ctgctgccga aggcaccgga gaaggacgcc gtcggcgagc agcggtaccg
    13861 gttgtggtcg cggtacttca ccggtgcccg cctcgacctg caagaggcgt acgagtgggg
    13921 atggcaggag ttcgccggca tcgaagcgga gatgaagcag atcgcgaacc ggatcaggcc
    13981 gggcgcgtcg ctcgccgagg ccgcggccgt gctggacgcg gacccccgct atcaggtgca
    14041 cgggcaggac cggttcgagg cgtggatgca gcggttgtcc gaccaggcgc tgcaggacct
    14101 gcgcggcacc cacttcgaga tcccggaccc gctgatgcgg ctggagtgca agatcgcccc
    14161 gccgggcggc ggcgtcggcg cctactacac cggcccgact gacgacttct cccggcccgg
    14221 ccggatgtgg tggtcggtgc ccgccgaccg gcaggacttc cccacctggc gcgaagtgtc
    14281 cactgtgtac cacgaggggg tgcccgggca tcacctgcag gtcgcgaccg cggtgcacga
    14341 ggcgcagcgg ctcaacaagt tccagcggct ggcctgcttc gtctcggggc acggcgaggg
    14401 ctgggcgctg tacgccgaac gcctgatgcg cgagctcggc tacctcgaag acgacgggga
    14461 cctgctcggc atgctcaacg accagctctt ccgcgcggcg cgcgtggtgg tcgacatcgg
    14521 catgcaccta gagctggaga tcccggccgg caccggtttc cacgagggcg agcgctggac
    14581 cccggaactg ggcctggagt tcatgctgag ccggaccatc accgacccgg cgcaggtccg
    14641 cgacgagatc gaccgctacc tgggctggcc gggccaggcg ccgtcctaca agctcggcga
    14701 gcgcctctgg cgggcggccc gcgacgaggc caggcagcgc cacggcgcgg ctttcgacat
    14761 gaaggagttc cacacgcagg cgctgaagat gggcggcatg ggcctcgaca ctctccgcga
    14821 gcagctagcg ctgctgtgat cacgcagtga ggggcgcccg cgacccgatt gccgggtcag
    14881 gggtgcccct cacccttcca gaaccatccc gcgacggggt ggctgaacca ggaaccgctt
    14941 ggatcgcgca cgattgggtt gtggagtcgg cgatttcgcg cgaaatcgcc aactgccacg
    15001 cctgcaggcc tggcgatttc gcgcgaaatc gccgccttcg ctaccgggac cgctgcccga
    15061 agcgggcgtc gtggtcagcg gggttcgagg gggagggagc ggcccaggac cgcgaagggc
    15121 cgcgggtcgc ccgtgaagcg gtagtcgcgc aggacgtccc cgaagccgac ccggcggtac
    15181 aggcgccagg ctcgggtcgg cccttccggc gtcgacagca ggaccttgct gccctgcgcc
    15241 ccggcgagca ggcggcgcag gacctcttcg ccgaggccga cgccctggct gcccgggtaa
    15301 acgtgcagct cggtcagttc gaagtagtcg tccagccagg cttcggcatc gccgccgctg
    15361 ctgagcaggc cgcggcgaac ctgctcgtgc caccactgcc cgggggcgcc caggtagccg
    15421 tagccgaggc cgacgagctc atcgcggtcg ttgaacgcac cgacgcaccg ccatcccgcg
    15481 cgcagcatgt gcgccgacca catcggggcg cgctgctggg cggtcgcggg tgggtagttc
    15541 atcgcggtca cgtagatctg cagggcctcg gggagccggg cccggagctg gtccgtggtc
    15601 agctcggtga tccgatcgaa gctgggggat ggcgcggcgg tcacggccga acactaacgc
    15661 cttcccagcg cgcggtcctt ctcgcggccg atcctgccgt cgaggcggct tcaccgggtg
    15721 ccggattcgg ccactcgggt gatcatcttg tctgatcatg cctcgaacag gtgagctacg
    15781 gcgcattgct tgagtccgtc ggttgggcga gctaatctgt aagtgttcga acgcgagttc
    15841 gatgaactcc agttcgggca tcgagtccgg cggtggggtg ggggaagcac cccgccgccg
    15901 gacctgccgg ctccccgcgg caggcgtgga cggcttcgtc gtgcagagga gactgccgat
    15961 gtctttttcc actgatctct cgattcctgc tccgcggcgc tccgtggaga accacgaacc
    16021 gacaccagag gccgagacac cggccggctc cctgtcgttg ctgctcaacg cgcgaacgtg
    16081 cttgcacgag gcggaggagg ccgaccgccc cggggagcgg tacgtcgccg cgcatgtggc
    16141 cgcgttacgc gcggcgaccg cggtcgtcgt ggcgcgctcc tggcggcggg agaacggtcg
    16201 tccggccagc gcgtggacgt tgctgaccgg ggccgctccc gagctgcggg agtgggcggc
    16261 gtacttcgcg gcgcgctcgg accggcgggc cgcggcggag gctggggtgc ccaccatcac
    16321 ctggctggac gccgatggac ttctggcgcg cagccgggaa ttcctcgaca tcgtggggcg
    16381 aagcctgttg ggggtggctc gatgaacggt actgaagtga ggctcgacta cgggcggatg
    16441 ctggacctgc tcggcatcga ggcccagctg ctcaccgcgg cgacccatga cgcgcacgtc
    16501 cacgcgccgg tgtggggcgc gtccgggagg accttggggc agaccgtccg gcacctgggc
    16561 gatctgtgcg aggacacgct gtcctggctg ggctcgtctg ccgtggagcg gcgctgggac
    16621 ctgccggacc agcccgagct gcgcgaggtg accggccggt tcgccgtccg gttggcggat
    16681 ctgctcgccg agctcggcgc caggccgccg cacgatccgt gtccgacgtg gtggccggag
    16741 cagcacaccg tgcggttctg gctgcgccgg atgctgcacg ccacgacggt gcaccgggtg
    16801 gacgtgcagg ccgcagcggg ggtgctgccg actccgatcg agcccgacgt ggcgaccgac
    16861 ggcatcgacg aggtgctgcg gctgtggttc ggctaccggt tgcacgcgct cggcatcacc
    16921 gcgacgcgcg cctgttcggt cggggtgtac gtggagggcc ggaattggct ggtcaccgcc
    16981 gaccagaacg ggaccgcggt ggtgagctcg gacgacgtgt cgaccgcgac gcccgacgcg
    17041 gtcgtcggcg gcgatgcgcc cgccgtctac ctctggatgt ggggtcggct gcccgatcgc
    17101 gcggtggaga ccagcggcga tctcgacgcg atcgcacagc tgtggggcct cctgcagctg
    17161 gccacccgct gagcacgccg cccgcggccg gtcgcgggtg tgcgaccggc ttcgcgccgc
    17221 ggcacgtcat tcgcgtcggc ggcacggctg ggttcgacat gtgcgggtgc cgcttcggcg
    17281 ggaaattccc gttcatgcgg ccgcgttcac gaaaaccgct aagttgggcc agattcgggt
    17341 ggaggcgagg ttcgtccccg gctgcgtgct cgcgtgcttg ccgtccaccc ggcgtcgttc
    17401 cgaggcgagt tcccttgcgg caagccgata atctggactc caatcggcgg ataccccggc
    17461 cttcgggccg gggaggagtc gatcctgagg ttgttggcct cctccgtctc gacgatcggc
    17521 ttggccgggc aagggagctt gccgtcgccg cgcaattcgg ggagttgatc caacggcacg
    17581 tgaaccgcgg aaccgaggcc cgtgctcagg cacgcagccg gaggcccttg ggcgtggcgc
    17641 ggaatcccgc ttcggtgagc acttcggcca ggcgggaccc ccaagcgtct tcgccgtcgg
    17701 cgcgttgcac cgcgagctgc tccagccagc cgtcccggac cacccgggcc agcccggccg
    17761 ccgcgctgcg cagggcggat tcgtcgccgg tgaacgacag caacgacttc ccgccgcgtt
    17821 cgacgtagaa cacggcttcg ccggacacga gcaccacgag cgcaccggcc ttgcggcccg
    17881 gtcgatgccg ggtttcgccc atcaccgcag gccattccag tgcagccccg taaggctgcg
    17941 cgggatcggc agcggccagc accaccgcgt cgccggcact gtcctcgcgg gacatggccc
    18001 gcaggcggtc gatcgcaccg ggcaccgcga actgcgcggc gccgaggccc tcgatgacgt
    18061 acccgcgtcg gcaacgaccg gattcctcca tggcgcgaag aaccttgtac accgcggaaa
    18121 acccgcccgt gacgcgctcg atgtccagcg ctccgcgcgt cagcaccccg tgccgctcca
    18181 ggaaggcctc ggcccgcgcg tgcgctcgac gggtcgggtc gcccgacggt tgtggcgcca
    18241 gcgaccaacg tccggacacc gtgggcgggc cactgcggct gggcatcgac ggacggcctg
    18301 cgcgcaaccg cgcgtagcgg ccgcgcggtg cgctccggcg tggcttgtgc gccgcgccgc
    18361 ggccggaaac caaggcccgc aacggtgcca gggtgtcgtt ggtcgccgtg ccggaccaga
    18421 ccaggtccca caaagccgaa gtgaccgcgt cgtcggcggg cgtggcctcg ccctgctcca
    18481 ccagcagggc tcccgcacga tccgccagct ggcggaagaa caacgcgcca ccgtccaatg
    18541 cggacacgac agcgcggtgc agcggcgaat cggcggcgga ctcctccggc aggtccggaa
    18601 gcagcaggtc ggcgacatcg gtgggcgcca acgcgatcca gccgtcgccg ccggccaggg
    18661 agccggagcc gacccaggtg acctcaccgg tggcggtcag ctcgtcgagc agcgcggggg
    18721 agtagccggg cagtcgggcg ggcaggatca acgactccaa cccgctcgcc ggaaccggcg
    18781 cccccgccag ttgctcgacc acggcgtaca cgtcgtccac cgtgggtgcg gagcgcaacc
    18841 gggctccgat gccgtgccac gccggcagga aacggcccag cgcggccggt tccaccggtt
    18901 cgacctccgc gcgaagccgc gccagcgacg cccgccgcag ccgccgcagc acttcggcgt
    18961 cgcagtactc cagcgccccg ccaccaccgg cctccaacgg ccgaagctcg ccgcggacca
    19021 accgcccgct gccggtcaac cggtccagca cgccgtggac gacggccact cccaacccga
    19081 atcgctgcgc tgcggcatcg gcggtgaacg gtccgcggca gcgtgcgtag cggatcagca
    19141 ggtcgcccag cgggtcagcg accggctcgg tgaacgcctc cggcacgccg accggcagtg
    19201 cgacgcccag cgcatcgcgg accttgccgg catcctcgat cggaatccag cgctcttcgc
    19261 ccgcgatgcg gacctgcagc actcgtcgct gtccggccag gtcggccagc cactccggcc
    19321 gcacgccccg cgcctcggct tcggccgcgg tcagatctcc caggaagcgc aaaatgtcta
    19381 ttgcggactc gttgtcgcgg gcgtgccgtt ccggggcgag ccgttgcagc tgctgctcga
    19441 tctcgtcgag cgcctccggg tcgagcagct cccgcagcgc ctccgaaccg agcagctccg
    19501 ctagcagcgt cgaatccagg ctcaacgccg ccgaccggcg ctccgccagc ggcgcatcgg
    19561 tctcgtacag gaacatgccg atgtagccga acagcaggct gcgcgcgaac ggcgacgggg
    19621 tcggggtctc gacctcgacg actcgcacct tccgcgccgc gacctgcgac atcagctcag
    19681 tcaaaccggg caggtcgtag acgtcctgca ggcattcccg catcgcctcc agcacgatcg
    19741 ggaactgctc gtactgtgcg gccaccgcca gcaactgcgc ggctcgctgc cgctgctgcc
    19801 acaacggcgt gcggcggcgc ggatcccggc gcggcagcag cagggcccgc gccgcgcact
    19861 cccggaaccg ggccgcgaac agcgccgagc cgccgacctc gtcggtcacc acctgctgga
    19921 cttcttccgg cggcaacagc acgtcctcgg cggtcggcag cacttccgcg ccggactcgt
    19981 ccagcgcatc ggccagccgc agcacgatcc cgtcgtcgga agaggcgacc tgcggctcga
    20041 tcccgcgccg ctcccggatc cgggctccga tcgccagcgc ccacgggccg ttgaccttgg
    20101 ctccgaacgg cgaatgcacc accatccgcc agtcgccgag ctcgtcgcgg aaccgctcca
    20161 ccacgatcgt ccggtcgtcc ggcacgtgcc gggtcgcccg ccgctgttcg tccaagtagg
    20221 acagcaggtt gtcctgggcc cactcgtcca gcccggccgc cgcgatgcgc gaccgcgccg
    20281 ccggggtgtc cgcgccgatc agctcccgga cgaaggcgcc cagggcgcgc ccgagctcca
    20341 gcggccgtcc cggcgaatcg cccttccaga acggcatccg gcccggctcg ccaggcgcgg
    20401 gcaccaccac gacccggtcg tgggtgatgt cctggacccg ccaagccgag gtgccgagca
    20461 ggaaggtgtc gccgacccgc gactcgtaga ccatctcctc gtcgagctcg ccgacccgca
    20521 ccccgccctt gcccgcttcg tctgcgggcg tggtgaccgt gaacagcccc cggtccggga
    20581 tcgtgccgcc ggaggtcacc gcgagccgct gcgcaccggg ccgcgcgcgc agctcgtcgt
    20641 tcacccggtc ccacacgatg cgtgcgcgca gctcgccgaa ctcctcgctg gggtaccggc
    20701 ccgccagcat gtccagcacc gcgtgcagcg cagagtccgg aagccccgcg tagggcgcgg
    20761 cccgccgcag cagcgccgcg agctccggca ccggccaggt gtccatcgcg accatcgaca
    20821 cgacgtgctg cgcgagcacg tccagcgggt tgcgcgggaa ggacagcgac tcgatcagcc
    20881 cgtcggccat ccgctccgac accaccgcgc aaccgacgag atcgccccgg aacttcggga
    20941 acaccacgcc ccgcgaaacc gcgccgacct ggtgtccgcc gcgcccgatg cgctgcagcc
    21001 cggaggccac gctcggcggc gtctccacct ggatcaccag gtccaccgcg cccatgtcga
    21061 tgcccagctc cagcgacgac gtggccacca cgcaggccag ccgcccggac ttgagctcct
    21121 cctcgaccac c
//
