LOCUS       NZ_CP040605            21194 bp    DNA     circular CON 25-AUG-2024
DEFINITION  Saccharopolyspora sp. ASAGF58 chromosome, complete genome.
ACCESSION   NZ_CP040605
VERSION     NZ_CP040605.1
KEYWORDS    RefSeq.
SOURCE      Saccharopolyspora sp. ASAGF58
  ORGANISM  Saccharopolyspora sp. ASAGF58
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 8045912)
  AUTHORS   Guo,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-APR-2019) Grain Processing Research Group, Academy of
            National Food and Strategic Reserves Administration, Baiwanzhuang,
            Beijing 100037, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.15x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012277335.1-RS_2024_08_25
            Annotation Date                   :: 08/25/2024 04:20:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,606
            CDSs (total)                      :: 7,535
            Genes (coding)                    :: 7,265
            CDSs (with protein)               :: 7,265
            Genes (RNA)                       :: 71
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 270
            CDSs (without protein)            :: 270
            Pseudo Genes (ambiguous residues) :: 0 of 270
            Pseudo Genes (frameshifted)       :: 80 of 270
            Pseudo Genes (incomplete)         :: 228 of 270
            Pseudo Genes (internal stop)      :: 14 of 270
            Pseudo Genes (multiple problems)  :: 48 of 270
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:54:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1114905
            Orig. end                         :: 1136099
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040605.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21194
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="4"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21194
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21194
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11194](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11194)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(129..146)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            complement(332..1576)
                     /gene="dxr"
                     /locus_tag="FDZ84_RS04960"
                     /old_locus_tag="FDZ84_04970"
     CDS             complement(332..1576)
                     /EC_number="1.1.1.267"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0030604 - 1-deoxy-D-xylulose-5-phosphate
                     reductoisomerase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dxr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010306071.1"
                     /locus_tag="FDZ84_RS04960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_04970"
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /protein_id="WP_210435429.1"
                     /transl_table=11
                     /translation="MTVMHADTPNQSAPGDPRTVLVLGSTGSIGTQALDVIRHNPDRFR
                     VAGLAAGGSDPQALAEQALEFDVPAVAVAKGTAVEDVQLALYAEAQQRGYAAGEFRLPR
                     LLAGPEAVTDLIESTPADVVLNGVDGSRGLKPTLTALATGAQLALANKESLIAGGALVL
                     GSAAPGQIVPVDSEHSALAQCLFGGRSDEVERLVLTASGGPFRGRKRDELVDVTVQQAL
                     AHPTWTMGSVVTINSATLVNKGLELIEAHLLFGIDYDRIDVVVHPQSIVHSMVTFVDGA
                     TIAQASPPNMRIPIAMSLEWPRRVPKAAPALTFEQAQEWTFEPVDNEAFPAVELARAAG
                     SGGGCLPAIYNAANEEALAAFVDGRLRFTGIVQTVGEVLAGADQWRSDPAGLDEVFAAE
                     DWARTRARELAGKAE"
     misc_feature    1663..1674
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.96"
                     /tool="antismash"
     gene            1827..2111
                     /locus_tag="FDZ84_RS04965"
                     /old_locus_tag="FDZ84_04975"
     CDS             1827..2111
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010306064.1"
                     /locus_tag="FDZ84_RS04965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_04975"
                     /product="DUF2631 domain-containing protein"
                     /protein_id="WP_168584917.1"
                     /transl_table=11
                     /translation="MASTELEKKPSQAIDPAEEPSVEWGWHGGFPKGTQFMGWFSVVAC
                     LAMLIGNHQGIFSGGEHFKTEDGYLVFIAAVLVIGLLIDLRKKRTAWRR"
     gene            complement(2395..3828)
                     /locus_tag="FDZ84_RS04970"
                     /old_locus_tag="FDZ84_04980"
     CDS             complement(2395..3828)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010306063.1"
                     /locus_tag="FDZ84_RS04970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_04980"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_168584918.1"
                     /sec_met_domain="Aldedh (E-value: 1.2e-136, bitscore:
                     454.8, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVTGYWVAGERVTSDATFEVRHPYDDVAVATTCYATDADVERA
                     VAAAHAVRREFAELPAHARAAALDHVSRRLTERAEEIAQLITAENGKPITWARGEVARA
                     VSTFRWGAEEARRFSGELQRLDTDAGATGRMALIRRIPRGPVLGISPFNFPLNLVAHKV
                     APALAVGTPIVLKPAPKTPLSALLLGEILAETELPAGSWSVVTTTNEKAAELVADPRLP
                     VVSFTGSGPVGWGIRDSAPRKHVTLELGGNAAVIVNSDWADLDYAAERIATFAVYQGGQ
                     SCISVQRVYAHRDIVDDLTARVVKAVEAQGTGDPKDPATKVGPLIDLAAAERVEQWVGE
                     AVAAGARVLTGGTREGTTYAPTVLADAPEDAKVSCEEVFGPVLVIAPVDSVDEAFEKVN
                     ASRYGLQAGVFTRDLQLAFRASSELEVGGVIIGDVPSFRADQMPYGGVKESGVGREGVR
                     AAMTDLTEEHVTVLTGINP"
     gene            complement(4116..5576)
                     /locus_tag="FDZ84_RS04975"
                     /old_locus_tag="FDZ84_04985"
     CDS             complement(4116..5576)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010306050.1"
                     /locus_tag="FDZ84_RS04975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_04985"
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_168584919.1"
                     /transl_table=11
                     /translation="MPLTVRDLVAAAELGLAARAGARELDRPIAWVHTSELADPAPFLE
                     GGELLLTTGLALRPEDCAGLVERLTAVGVAGLGFGVGLSHREIPAELVKAAESAGLPLL
                     EVPRPTPFIAISKAVSRAVAADEYASLRRTSRAQHELAQAAGTTNGVAALVRKLATLLD
                     AWVLLLDAGGRLLHSAPAAAGSRLPQLEPEVAKVRAKRGLAAAGFSLGDQEVSMQALGG
                     RARGFLAVGRGGPFATTDHHVINSAASLLTLALEQVEALATARRRLRAGFLDLMLRGEP
                     VQDVLPDLHAELPPEPFRVVALAGARDRDELLTRLAAVQPSAPAYLAEHGDSVVGLVDG
                     GALDWLTGQPGVAVGVSEPCEVAGLAEGLRQAQQAARAAKRSGTAVRFGDLAGYGLLNL
                     VPGTDAQAFAEALLAPLRGHDTLIESLQTWLAHHGQWDPAANRLGVHRHTLRNRVRKVE
                     ELLGRGLDQPGVRAELWLALQVLDRPGE"
     gene            5775..7148
                     /gene="gabT"
                     /locus_tag="FDZ84_RS04980"
                     /old_locus_tag="FDZ84_04990"
     CDS             5775..7148
                     /EC_number="2.6.1.19"
                     /GO_function="GO:0003867 - 4-aminobutyrate transaminase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009448 - gamma-aminobutyric acid metabolic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (46-383). E-value: 3.2e-111.
                     Score: 363.5. Matches aSDomain:
                     nrpspksdomains_FDZ84_RS04980_Aminotran_3.1"
                     /codon_start=1
                     /gene="gabT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073117.1"
                     /locus_tag="FDZ84_RS04980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_04990"
                     /product="4-aminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_168584920.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.7e-129, bitscore:
                     430.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSPAQAALPQARVLRTEIPGPNSRELQRRRTAVVSTGVASVLP
                     VFIAEAAGGVLHDVDGNSLIDLGSGIAVTNVGNAAPEVAEPVRRQVGEFTHTCFMVTPY
                     ENYLQVCEELAALTPGDHEKRSALFNSGSEAVENAVKIARRATGRQAIVVFDHAYHGRT
                     NLTMALTAKSVPYKHGFGPFAPEIYRVPMSYPARDSRTGEQVAREAIDRIEKQLGADSV
                     AAVLIEPIQGEGGFIEPAAGFLPAISRWCTDNGVLFIADEIQTGFCRTGAWFACDHENV
                     VPDLITTAKGMAGGLPLAAVTGRAELMDAMPPSSLGGTYGGNPVACAAALGAIRAMRER
                     DLATAARDIGDLVFPRLRELAETTDAILDVRGRGAMIGIEFVKPGTIDPDPEVTAKIAK
                     ACHAQGVVILTCGTYGNVIRLLPPLVIDHALLEEGLAVLEEAIREHTRRSAGPGRSAG"
     aSDomain        5913..6923
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FDZ84_RS04980_Aminotran_3.1"
                     /evalue="3.20E-111"
                     /label="FDZ84_RS04980_Aminotran_3.1"
                     /locus_tag="FDZ84_RS04980"
                     /protein_end="383"
                     /protein_start="46"
                     /score="363.5"
                     /tool="antismash"
                     /translation="FIAEAAGGVLHDVDGNSLIDLGSGIAVTNVGNAAPEVAEPVRRQV
                     GEFTHTCFMVTPYENYLQVCEELAALTPGDHEKRSALFNSGSEAVENAVKIARRATGRQ
                     AIVVFDHAYHGRTNLTMALTAKSVPYKHGFGPFAPEIYRVPMSYPARDSRTGEQVAREA
                     IDRIEKQLGADSVAAVLIEPIQGEGGFIEPAAGFLPAISRWCTDNGVLFIADEIQTGFC
                     RTGAWFACDHENVVPDLITTAKGMAGGLPLAAVTGRAELMDAMPPSSLGGTYGGNPVAC
                     AAALGAIRAMRERDLATAARDIGDLVFPRLRELAETTDAILDVRGRGAMIGIEFVK"
     gene            complement(7362..8342)
                     /locus_tag="FDZ84_RS04985"
                     /old_locus_tag="FDZ84_04995"
     CDS             complement(7362..8342)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028841.1"
                     /locus_tag="FDZ84_RS04985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_04995"
                     /product="PHB depolymerase family esterase"
                     /protein_id="WP_371812783.1"
                     /transl_table=11
                     /translation="MVPGRAKRVFARHSSRLIRSGRLLVAVGVAMTLGGLPAQAEPARV
                     TDHPVPSTGCGKASAVAPGYSQTRTIVSGGITRSYLVHVPENYRQATPISLVLSFHGHK
                     RTSAYQAELSEFSATDAIAVYPQGLVGTDGETAWQGAPYSADADDVLFTGDLLDELQRD
                     FCVDPKRIYAAGKSNGGGFTGVLACRMSGRIAAFAPVSGAFYPQGGACEPERAAPILDF
                     HGNADATIPYPGNPDKGLPPIPEWLAGWADRNDCHDGPIVRDEGNGVQVSRWAGCGRGG
                     DVVHYKIEELGHDWPSMHPNPDSDEPAVIDATPIIMQFFARHQLR"
     misc_feature    complement(8274..8276)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8932..10067)
                     /gene="fxlM"
                     /locus_tag="FDZ84_RS40510"
                     /old_locus_tag="FDZ84_05000"
                     /pseudo=""
     CDS             complement(8932..10067)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.5"
                     /locus_tag="FDZ84_RS40510"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05000"
                     /product="methyltransferase, FxLD system"
                     /pseudo=""
                     /sec_met_domain="PCMT (E-value: 4e-26, bitscore: 90.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRHEFVPEADIEDAYHPWKAVITHRFEDGTSLSCASAPFVVAMM
                     LDQLDVRPGDRVLEIGAGTGYNAALLSELTGAAENVTTIDVDADVTDQASRGLEAAGYG
                     GVRVVTGDGAAGVPEHARYDRLIATVSPWDIPESWWISSPQVGAWWCRCGGAGRLAALP
                     SAIRTDASSRTPWNCAGSSTLSAMTRGSEPLPSRRTRQSACIGIVISLWTQKCSTGCST
                     SHERQPGPRSRSLGMSRMTESGCGSP"
     gene            complement(10001..11194)
                     /locus_tag="FDZ84_RS04995"
                     /old_locus_tag="FDZ84_05005"
     CDS             complement(10001..11194)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="FDZ84_RS04995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05005"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_246868805.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.3e-71, bitscore:
                     239.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.8e-10,
                     bitscore: 37.8, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAREDYQHHGTGLLRAAAGIAEPHWWPNPADEQECREWLRQTWT
                     LPGLAPAIRHASPVLAAQTESILAEESVSARNVQRAALAVVRYALRFTGRSTPFGMFAG
                     VSTASVGATTKAQWGASHRPVAHADNRWLHQVIERLEGCVELLGRLDVIFNSSTELRGA
                     RLELPGQDKISVRKSGAVLKVRDAATSPIRFDVLADRLVRSFPGAGDPRGMLISLVRNG
                     FLLTALRAPSTITDPFGYILGKLREVNAETSPVAPLVRELEEIRGEIRAHNDAPTEEAR
                     ERIVARMRNIADSVRVPLAIDLRLDAHVEIPAQVAKEMERAICWIPGPAGPLLRGTLAS
                     TCSVVPLDLPSIPLQGNPIGSLSGIFEAPQSASCAKCRAMSSSPKPTSRTPTTPGKQ"
     aSDomain        complement(10502..10741)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FDZ84_RS04995_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.60E-12"
                     /identifier="RREFam001.1"
                     /label="FDZ84_RS04995"
                     /locus_tag="FDZ84_RS04995"
                     /protein_end="231"
                     /protein_start="151"
                     /score="37.8"
                     /tool="antismash"
                     /translation="VIFNSSTELRGARLELPGQDKISVRKSGAVLKVRDAATSPIRFDV
                     LADRLVRSFPGAGDPRGMLISLVRNGFLLTALRAP"
     misc_feature    complement(10754..10756)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11254..11424)
                     /locus_tag="FDZ84_RS05000"
                     /old_locus_tag="FDZ84_05010"
     CDS             complement(11254..11424)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="FDZ84_RS05000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05010"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_168584922.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3.2e-13, bitscore:
                     48.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAILGPQQAIGDTSEDVFDLDLQVETEQVRPQEAACQTDDGCGH
                     TCEISACLSQR"
     gene            complement(11667..11954)
                     /locus_tag="FDZ84_RS05005"
                     /old_locus_tag="FDZ84_05015"
     CDS             complement(11667..11954)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF046811.1"
                     /locus_tag="FDZ84_RS05005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05015"
                     /product="RNase adapter RapZ"
                     /protein_id="WP_168584923.1"
                     /transl_table=11
                     /translation="MHRPELHDLSGLDKPVQDWVFAQENVRSWFEDLLNVLGPMVTAAE
                     KQGNPLVTVALGCQGGHDRSVAIALGLAEAFELAGTRSLIRHLSFVRGPR"
     misc_feature    12078..12092
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     gene            complement(12209..12460)
                     /locus_tag="FDZ84_RS05010"
                     /old_locus_tag="FDZ84_05020"
     CDS             complement(12209..12460)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS05010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FDZ84_05020"
                     /product="hypothetical protein"
                     /protein_id="WP_168584924.1"
                     /transl_table=11
                     /translation="MGDIQAGITTADQLAQDTQQALAQAADHLSEALHSLIQTTQGSQN
                     DEIGYVATTYEDIIEQIKRLHGNIWPCREKLDTYKNML"
     misc_feature    complement(12425..12439)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            complement(12473..12622)
                     /locus_tag="FDZ84_RS05015"
     CDS             complement(12473..12622)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS05015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_168584925.1"
                     /transl_table=11
                     /translation="MPGMEEVRARIAQANKKMQEGTARQHTNLVFDEAQQALVSTTESY
                     AGRM"
     gene            complement(13082..13423)
                     /locus_tag="FDZ84_RS05020"
                     /old_locus_tag="FDZ84_05025"
     CDS             complement(13082..13423)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313339.1"
                     /locus_tag="FDZ84_RS05020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05025"
                     /product="hypothetical protein"
                     /protein_id="WP_168584926.1"
                     /transl_table=11
                     /translation="MIAAWIAAGLLCVGALALSATFYYAPARHAGGGEGALTVAHLVAR
                     VEAETSGGRHCLREPRTVQLRGDLADALAVEETRFLPVVESGLPVGDREALARHPGMLR
                     RLLDALQRL"
     gene            complement(13621..13968)
                     /locus_tag="FDZ84_RS05025"
                     /old_locus_tag="FDZ84_05030"
     CDS             complement(13621..13968)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS05025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FDZ84_05030"
                     /product="hypothetical protein"
                     /protein_id="WP_168584927.1"
                     /transl_table=11
                     /translation="MSMPEKASSTQSAVWLRAGAQVIGWPLVLLGILGWVEASRFVGGA
                     LDRMNRGGAERFALALTAAALAVYGITASVGGCVIAAGLRGLLRILVAWASGALLLFHL
                     CVLYFALTMRF"
     misc_feature    complement(13657..13659)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13955..14170)
                     /locus_tag="FDZ84_RS05030"
                     /old_locus_tag="FDZ84_05035"
     CDS             complement(13955..14170)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS05030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FDZ84_05035"
                     /product="hypothetical protein"
                     /protein_id="WP_168584928.1"
                     /transl_table=11
                     /translation="MTTLTTVPCRDRASRDCDVVVSHASTAVWLRVGPEERLLDETQAQ
                     KLYLALGVHIAAVQTARHKAGPREHA"
     gene            14493..15674
                     /locus_tag="FDZ84_RS05035"
                     /old_locus_tag="FDZ84_05040"
     CDS             14493..15674
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010693485.1"
                     /locus_tag="FDZ84_RS05035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05040"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_168584929.1"
                     /transl_table=11
                     /translation="MSATTPDIGQRIATARKLAGLTQFQLAEKANYSEAMVQAVEQGKK
                     PASPRFIASAAKALSIEPELLTGQPYHFDNEKPLEGLPELRALIAEGTEVIVAPPAPLS
                     ELEADLAQISKWYWDDKGAKSLAAIPTFLRQVYGAAHAANSVHDRGRAYTLLSAGWAQA
                     EQLSRRFGALTLSVPCLDRLDAVAQHADDPVYAAKATQKRARVLMYYGTFDSGRAARSA
                     ERLAELPDSEPILAARGSAHLCTAIVAARGGDRPTARAHLREARELGARVGHESPHYGT
                     KFGPGNVTIHEVAVALEAGDPEQAARLGSSTRLPADVSSPRLAHHWQDVARAWLLSGDP
                     ARSLQALNMARKVAPQQTRRHPQVRETVRMIAEAERRRTDSLTAFTSWLGTPA"
     gene            complement(15734..16456)
                     /locus_tag="FDZ84_RS38565"
     CDS             complement(15734..16456)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS38565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_246868806.1"
                     /transl_table=11
                     /translation="MPAISTTNQPTPNELIFAPVGIAHLTRDNTDLLRSAARGRQRLRV
                     TTAAQLNGTPHLGTVVTVLTVFALTAHAAEQLNLPATVIFDALENAPGETVEIDGETYT
                     RTVGDLIDSGHLDRVERVSGFQRLLDWAAARSHIRYEFRPYSVYQGLRPVGRPDPPAVT
                     GRAACQMVWTRAPGSPIPPSVRNPALTRGVSHQSGKEGMTRCPDSTPTLPLWRSFRKGP
                     RIPGLAKLDRPGIFFVRQ"
     gene            complement(16411..17124)
                     /locus_tag="FDZ84_RS05045"
                     /old_locus_tag="FDZ84_05050"
     CDS             complement(16411..17124)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010694029.1"
                     /locus_tag="FDZ84_RS05045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05050"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_246868807.1"
                     /transl_table=11
                     /translation="MAGAQEYWRRYYAEQFRFGLGTEDILAALMQIPPVTTWADLGCGS
                     ESMLWATALRAQRLVAVDIDTQRLEILRQFVTTAQPRGIHVTALELCGRTDPDAFEARC
                     RSLTALIQADFLSSLPPTDPRLIGQSFNLVTQFGLLGLCRDANHFTTSFAHIHRLLAPG
                     GWVGGANWVARHAPSRVELTRQLYTTAATRAGVHLLLLKRIRIPDPDFTAVWIYIGRKT
                     PCPRSALRTSRHQTN"
     misc_feature    complement(16852..16854)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17139..17933)
                     /locus_tag="FDZ84_RS05050"
                     /old_locus_tag="FDZ84_05055"
     CDS             complement(17139..17933)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025033.5"
                     /locus_tag="FDZ84_RS05050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05055"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_168584931.1"
                     /transl_table=11
                     /translation="MTTTGTGTGTEAVIESYQRRAAFARAETAHLARPRLLRGLLPAVD
                     HVAEIPCGAGHFLADYARSALAVTLVDASAAMLAAATENAVHSGLSDEKTRRHLAYVQQ
                     PPDLTSVGLIVVPNAALNQLACQTALVELLMVLRAAVAPWAVVLAQVACVHPGGGVDTA
                     GFYDPARQHGVWFADRWFHPEQAGGAVLRRRRQHRHGERLQIQFDYRSPAGSSLHATAI
                     ELALFNAADLRDAFTTAGFGRVRFLPGQDGMSEVLAAAGAKP"
     misc_feature    complement(17523..17525)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17930..18520)
                     /locus_tag="FDZ84_RS05055"
                     /old_locus_tag="FDZ84_05060"
     CDS             complement(17930..18520)
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013430.5"
                     /locus_tag="FDZ84_RS05055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05060"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_371812784.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.7e-09, bitscore:
                     34.9, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVIGSGNVGSAAARTAAALGARVTVLTRCEGSADEYRPHAPTGV
                     RVAVNTARIRRELISQADLVIGAILVSTFDTPSMISEADLQDMKPGSVIVDATCGYGDG
                     YLPTAGGVQEPGEPPRVVHGVLHIKLDALPALVPVTATQAYTTNALPYLVRLARVVLFG
                     DADPAVATARIAHDGELVHPVCREHAAYFGVAS"
     misc_feature    complement(18461..18463)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18511..18717)
                     /locus_tag="FDZ84_RS38570"
     CDS             complement(18511..18717)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS38570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_246868809.1"
                     /transl_table=11
                     /translation="MLSALMDSKISAYSYEFLAEHGRFPLAAPGGQIAGIQAALRGAQA
                     LQEFSGRGVLLAEVAGAVRPRWS"
     misc_feature    18696..18713
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            complement(18819..19931)
                     /gene="rlmN"
                     /locus_tag="FDZ84_RS05060"
                     /old_locus_tag="FDZ84_05065"
     CDS             complement(18819..19931)
                     /EC_number="2.1.1.192"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0016433 - rRNA (adenine) methyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0030488 - tRNA methylation [Evidence IEA]"
                     /GO_process="GO:0070475 - rRNA base methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rlmN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019818380.1"
                     /locus_tag="FDZ84_RS05060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05065"
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="WP_168584932.1"
                     /sec_met_domain="PF04055 (E-value: 3e-20, bitscore: 72.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATSLPLVFDAPRRGMPPRHLADLSADERRAAVTELGEKPFRAK
                     QLAHHYFGRLNADVESMTDIPAASRAKLAEHLLPPLLNPVRHLNTDDGTTRKTLWRAHD
                     GTLLESVLMRYPDRATVCISSQAGCGMACPFCATGQGGLQRNLSTAEIVDQVRSAAAAM
                     RDGEVQGGPGRLSNVVFMGMGEPLANYRRVINAVHRICDPAPEGLGLSQRSVTVSTVGL
                     APAIKKMTAENLHVTLAVSLHTPDDELRDTLVPVNNRWKVAEVLEAARGYADHTGRRVS
                     IEYALIRDINDQPWRADLLGKLLHRHLGPFAHVNLIPLNPTPGSKWDASPKPVEREFVR
                     RVREAGVPCTVRDTRGQEIAAACGQLAAEG"
     gene            20055..20732
                     /locus_tag="FDZ84_RS05065"
                     /old_locus_tag="FDZ84_05070"
     CDS             20055..20732
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010306033.1"
                     /locus_tag="FDZ84_RS05065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_05070"
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="WP_371812785.1"
                     /transl_table=11
                     /translation="MAERPSPSVEDYLRAIYGLSERGVPVTNATLTQRLGLSPSSVSGM
                     INKLAQLGLVTHVRYRSVELTPEGRRLACDVLRRHRLIELFLVVELDYSWDEVHREADA
                     LEHAVSDELVAHIAAKLGNPTRDPHGDPIPTAEGTVEKPATLLLDQVEPGTIGTIARVW
                     DTDSELLRYLTEHSMTLGSRIEIVERKPFGGPLVVRVGEPPQDETHFVGNEIAAALSIS
                     VHR"
ORIGIN
        1 cctcgggggt gatctcctcg gcggacatct ggcgggcgtc ctcgatcatg gcccgccacg
       61 gtgcggacga cgcggtgcgc ccgtacttct cgtccttctt cggcgggaac atgccgatca
      121 tccggatgta gccgccgaat gggatgagct tcacgccgta ctcggtgtcg cccttcttgc
      181 gcgaccagat ggtgcggccg aagccgacca tgtactgggt gaccttgatc ccgaacagct
      241 tcgccgccgc caggtgcccc agctcgtgcc acgcgatgga gaacagcaac ccgaggaaga
      301 agatgacgat gccaacgacg accagcatct actactccgc cttccccgcg agctcgcgag
      361 cccgggtccg cgcccagtcc tcggccgcga agacctcgtc caagcccgcc ggatcgctgc
      421 gccactgatc tgcgccggcg agcacctcac ccacagtttg cacgattccg gtgaagcgaa
      481 gccggccatc gacgaaggcc gcgagcgctt cttcgttcgc cgcgttgtag atcgcgggca
      541 ggcagccgcc gccggagccc gcagctcggg ccagctcgac ggccgggaac gcctcgttgt
      601 ccaccggctc gaaggtccat tcctgcgcct gctcgaaggt cagcgccggg gcggccttgg
      661 gcacccggcg cggccattcc aggctcatcg cgatcgggat ccgcatgttc ggtgggctgg
      721 cctgggcgat cgtggcgccg tctacgaagg tgaccatcga gtgcacgatc gactgcgggt
      781 gcaccacgac gtcgatgcgg tcgtagtcga tgccgaacag caggtgcgcc tcgatcagct
      841 ccagaccctt gttgaccagc gtggccgagt tgatggtgac cacgctgccc atcgtccagg
      901 tcgggtgggc cagcgcctgc tgcaccgtga cgtccacgag ctcgtcgcgc ttgcggcccc
      961 ggaacgggcc gccggaggcg gtcagcacca gccgttccac ctcgtcggaa cgacccccga
     1021 acaggcactg cgccagcgcg gagtgctcgg agtcgaccgg cacgatctgg ccgggcgcgg
     1081 cgctgcccag caccagcgca ccacccgcga tcagggactc cttgttggcc agcgccagct
     1141 gcgcgccggt cgccagcgcg gtcagcgtcg gcttgagacc gcgcgagccg tcgacgccgt
     1201 tgagcaccac gtcggcgggg gtggactcga tgagatcggt gaccgcctcc ggcccggcca
     1261 gcagcctggg gaggcggaac tcaccggccg cgtagccgcg ctgctgggcc tcggcgtaga
     1321 gggcgagctg gacgtcttcg acggcggtgc ccttggcgac cgcgacggcc gggacgtcga
     1381 actccagcgc ctgttccgcc agcgcctgcg ggtcgctgcc gcccgcggcc agcccggcga
     1441 cccggaaccg gtcggggttg tgccggatca cgtccagggc ctgggtaccg atcgaaccgg
     1501 tcgagccgag caccagcacg gtgcgggggt cgccgggtgc gctctgattc ggggtgtcgg
     1561 cgtgcatcac ggtcattgtc cccgaagaag gtgagcaccc atcgctcgcg gtacgcaaat
     1621 cacttccggg gctcacgatc actcatcgcc tggggtgttg cggaaatcgc ttccacaaca
     1681 cccttttccc tgatcgcagg gggcaggtgc gcgctcgggc gccgggggcg tgtgcgagga
     1741 tgggggcaat gtggatcgcc ggacggcggt ctgcgcacct agcaatgtct tccggcctcg
     1801 cggccggcgt ggcacaggag gggaacgtgg cgagcaccga gctggagaag aagcccagcc
     1861 aggccatcga cccggccgag gaaccgtcgg tcgagtgggg ctggcacggc ggtttcccga
     1921 agggcaccca gttcatgggc tggttttcgg tcgtcgcgtg cctggccatg ctgatcggca
     1981 accaccaggg catcttcagc ggtggcgagc acttcaagac cgaggacggc tacctggtct
     2041 tcatcgcggc ggtcctggtc atcggcctgc tgatcgatct gcgcaagaag cggaccgcct
     2101 ggcgccgctg acgcgccgaa agcatgaaag aacgccgccc cggtgaccgg ggcggcgttc
     2161 tttcattact gcgctggttc tcgacccagc ccgatcaggt ttcctggtgt tctgaagcgg
     2221 cgcagccgct cagcccaccc gcgcgaccgg caccgccgcg ggacggcgcc caccccgttg
     2281 ggtttccccg acgcacgtgt tgggtccgca cctgcgtcga ggaacccgca gcgagcaggc
     2341 gtccgaggtt ccgctacccg caccgccgcg cagaaggagc ctggaagcag cggttcacgg
     2401 gttgatgccg gtgaggactg tgacgtgctc ctcggtgaga tccgtcatcg cggcccgcac
     2461 gccttcccgg ccgacgcccg actccttcac cccgccgtag ggcatctggt cggcgcggaa
     2521 gctcggcacg tcgccgatga tcacgccgcc gacttccagc tccgacgacg cgcggaaggc
     2581 cagctgcagg tcgcgggtga acaccccggc ctgcaggccg tagcgggagg cgttgacctt
     2641 ctcgaacgcc tcgtccaccg agtcgaccgg cgcgatgacc agcaccggcc cgaagacctc
     2701 ctcgcaggag accttcgcgt cctccggcgc gtcggccagc accgtcggcg cgtaggtcgt
     2761 gccctcgcgg gtgccgccgg tgagcacccg ggcgcccgcc gcgacggctt cgccgaccca
     2821 ctgctcgacc cgctccgcgg ccgccaggtc gatcagcggc ccgaccttgg tagccgggtc
     2881 cttcgggtcc ccggtgccct gcgcctcgac ggccttgacc acgcgggcgg tcaggtcgtc
     2941 gacgatgtcg cggtgggcgt agacgcgctg caccgaaatg caggactggc cgccctggta
     3001 caccgcgaag gtggcgatgc gctcggcggc atagtcgagg tccgcccagt ccgagttgac
     3061 gatcaccgcg gcgttgccgc cgagttcgag ggtgacgtgc ttgcgcgggg ccgagtcgcg
     3121 gatgccccag ccgaccggcc cggaaccggt gaacgacacc accggcagcc gcgggtccgc
     3181 gacgagctcg gcggccttct cgttggtggt cgtcaccacc gaccaggacc cggcgggcag
     3241 ttcggtctcg gccaggatct cgccgagcag cagcgcggac agcggggtct tcggtgcggg
     3301 cttgagcacg atcggggtgc cgacggcgag cgccggggcg accttgtgtg ccaccaggtt
     3361 gagcgggaag ttgaacggcg agatgccgag caccgggccg cgcgggatcc ggcggatcag
     3421 cgccatccgg cccgtcgcgc ccgcatcggt gtcgagccgc tgcagctcgc cggagaagcg
     3481 gcgggcttct tccgcgcccc agcggaaggt ggagacggcg cgggcgacct cgcctcgcgc
     3541 ccaggtgatc ggcttgccgt tctcggcggt gatcagctgc gcgatctcct cggcccgctc
     3601 ggtgaggcgg cggctcacgt ggtccagcgc cgccgcgcgc gcgtgcgcgg gcagttcggc
     3661 gaactcgcgg cggaccgcgt gcgcggcggc gacggcccgc tccacatcgg cgtcggtggc
     3721 gtagcacgtg gtggcgaccg ccacgtcgtc gtagggatga cgcacctcga aggtcgcgtc
     3781 gctggtgacc cgctcgccag cgacccagta cccggtgacc gatgacatcg gctgcctcct
     3841 gtcgattttc gtcctcgccg cgacgctacg gccgcgcccc gagccaccgg cactgccaat
     3901 ccgtccaccg ccgcccacga ccatgtccaa accgtcatcc caccccgctc ggctagcgca
     3961 gcgtcggcgg aaaccacgaa gggactcgtg agtgctcgtt ccggcaagaa ccggactcag
     4021 cactcacgag ccttgggcgg gacggcagca ggtcgctgcc ccggcgttcg tcgtggacca
     4081 gcaccggccc gggcgccgcc cgggaggtgg ccccgtcact cgccgggccg gtccaggacc
     4141 tgcagcgcca gccaaagctc ggcgcgcacg ccgggctggt ccaggccgcg cccgagcagc
     4201 tcctccacct tgcgcacccg gtttcgcagg gtgtgccggt gcacgcccag ccggttggcc
     4261 gccggatccc actgcccgtg gtgcgccaac caggtctgca acgactcgat cagcgtgtcg
     4321 tgcccgcgca gcggggcgag cagggcctcg gcaaacgcct gcgcatcggt gccgggcacc
     4381 aggttcagca ggccgtatcc ggcgaggtct ccgaagcgca ccgcggtgcc gctgcgcttc
     4441 gccgcacgcg ccgcctgctg cgcctggcgg aggccttcgg cgagcccggc tacctcgcac
     4501 ggctcggaca cgccgacggc cacgccaggc tgaccggtga gccaatcgag cgcgccgcca
     4561 tcgacgagcc ccaccacgga gtctccgtgt tcggccaggt aggcgggggc gctcggctgg
     4621 accgccgcca gccgggtcag cagctcgtcg cggtcgcggg caccggccag cgccaccacc
     4681 cggaacggct cgggcggcag ctcggcgtgc agatcgggga gcacgtcctg caccggctcg
     4741 ccgcggagca tcaggtccag gaacccggca cgcagccgac ggcgggcagt ggcgagggcc
     4801 tcgacctgtt ccagcgccaa ggtcagcagc gaggcggccg agttgatcac gtggtggtcg
     4861 gtggtggcga acggcccgcc gcggccgacg gccaggaagc cgcgcgcccg gccgcccagc
     4921 gcctgcatgc tcacttcctg atcgccgagc gagaacccgg cggcggccag gccgcgcttc
     4981 gcgcgcacct tcgccacttc cggctccagc tgcggcagcc gggaaccggc cgccgccggg
     5041 gcgctgtgca ggagccggcc gccggcgtcg agcagcagca cccacgcgtc caagagcgtc
     5101 gcgagcttgc ggaccagggc ggccacgccg ttggtggtgc cggccgcctg cgcgagttcg
     5161 tgctgggcgc ggctggtgcg gcgcaggctc gcgtactcgt cggccgcgac ggcgcgcgaa
     5221 acggccttac tgatcgcgat gaacggcgtc gggcggggca cttcgagcag cggcagcccg
     5281 gcggattccg cagctttcac gagctcggca gggatctccc ggtggctgag cccgacaccg
     5341 aaacccagcc ccgcgacgcc gaccgcggtg agccgctcga ccaaccccgc gcagtcctcc
     5401 gggcgcagcg ccagaccggt cgtcagcagc agttcgccgc cctccaggaa cggtgccgga
     5461 tccgccagct cgctggtgtg cacccacgcg atcgggcggt cgagctcccg tgcaccggcc
     5521 cgcgcggcaa gccccagctc ggcagcggcg accaggtcgc gcaccgtcaa cggcaccggc
     5581 cacctcctga cattgtgtcg aatcctgaaa tccgagttaa ccagatcgtc ccctgttcgg
     5641 ttcggggtgc cggggtgact ctggtcgcag gacgaatgcg accggagcct gctccaagcg
     5701 gagataaccg cttgcgatgc ggggctcaat ctcacgcagg ccactttcga aacggttctc
     5761 aggaggtccc caccgtgacg gtttccccgg cccaggcggc actgccgcag gcgcgcgtgc
     5821 tgcgcaccga aatccccggc ccgaactccc gcgaactcca gcggcgccga accgcggtgg
     5881 tgtcgaccgg agtggccagc gtgctgccgg tcttcatcgc cgaggcggcc ggcggcgtgc
     5941 tgcacgacgt cgacggaaac tcgctgatcg acctcggttc gggcatcgcc gtcacgaacg
     6001 tcggcaacgc cgcgccggag gtcgccgagc ccgtgcgccg ccaggtcgga gagttcaccc
     6061 acacctgctt catggtgacg ccgtacgaga actacctgca ggtctgcgag gaactcgcgg
     6121 cgctcacccc gggcgaccac gagaagcgca gcgcgctgtt caactcgggc tcggaagcgg
     6181 tggagaacgc cgtcaagatc gcgcggcggg ccaccgggcg gcaggcgatc gtggtgttcg
     6241 accacgccta ccacgggcgc accaacctga ccatggcgct gaccgcgaag tccgtgccgt
     6301 acaagcacgg tttcggcccg ttcgcgccgg agatctaccg ggtaccgatg tcgtacccgg
     6361 cgcgggattc gcgcaccggc gagcaggtgg cgcgggaggc gatcgaccgg atcgagaagc
     6421 agctcggcgc cgactccgtc gcggccgtgc tgatcgaacc gatccaggga gaaggcggat
     6481 tcatcgagcc agcggccgga ttcctgcccg cgatctcgcg gtggtgcacc gacaacggcg
     6541 tgctgttcat cgccgacgaa atccagaccg gcttctgccg caccggcgcg tggttcgcct
     6601 gcgaccacga gaacgtggtc cccgacctga tcaccacggc gaagggcatg gccggcggcc
     6661 tgccgctggc cgcggtgacg ggccgcgcgg agctgatgga cgcgatgccg ccgagcagcc
     6721 tgggcggcac ctacggcggc aacccggtcg cgtgcgcggc cgcgctcggc gcgatccgcg
     6781 cgatgcgcga acgggacctg gccacggccg cgcgtgacat cggcgacctg gtgtttcccc
     6841 gcctgcgtga gctcgccgag accaccgacg cgattctcga cgtgcgcggc cggggcgcca
     6901 tgatcggcat cgagttcgtc aaaccgggca ccatcgatcc ggaccccgag gtgaccgcga
     6961 agatcgcgaa ggcctgccac gcccagggcg tcgtgattct cacctgcggc acctacggca
     7021 acgtgatccg gctgctgccg ccgctggtca tcgaccacgc cctcctcgaa gaaggcctgg
     7081 cggtcctgga agaagccatc cgcgagcaca cgcggcgatc ggccgggccg gggcggtctg
     7141 ccgggtaaca gccgcccgcg gcccatcttc cacgcaggcc acgcgacgga agcgggaacg
     7201 ccagccgacg aatgtcccgg caggagccgg caggagccag cacaaccgct cacgaccgca
     7261 tggggagctc ggcccggtgc gcgccgttcg ggggggttgg gcggcgcgca ccgggccgtg
     7321 cacgggtcgg ggctggttca tccggccccg gcccgggtct ttcagcgcag ctggtgccgg
     7381 gcgaagaact gcatgatgat cggcgtcgcg tcgatgaccg ccggctcgtc ggagtccgga
     7441 ttaggatgca tgctcggcca gtcgtgccca agctcctcga tcttgtaatg caccacgtcg
     7501 ccgccgcggc cgcacccggc ccaccggctg acctgcacgc cgttgccctc gtctcggacg
     7561 atcggcccgt cgtggcagtc gttgcggtcg gcccagcccg ccagccattc ggggatcggc
     7621 ggcaggccct tgtccgggtt cccggggtac gggatcgtcg cgtccgcgtt cccgtggaag
     7681 tccaggatcg gcgccgcgcg ctccggctcg cacgcgccgc cctgcgggta gaaggcgccg
     7741 gacaccggcg cgaacgcggc gatgcggccg ctcatccggc aggcgagcac accggtgaag
     7801 ccaccgccgt tggacttccc ggcggcgtag atccgcttgg gatcgacgca gaagtcccgc
     7861 tgcaactcgt cgagcagatc gccggtgaac agcacgtcgt cggcatccgc cgagtacggc
     7921 gcgccctgcc aagcggtttc gccgtcagtg ccgacgagcc cctgcgggta gaccgcgatg
     7981 gcgtcggtgg ccgagaactc ggagagttcc gcctggtacg ccgaggtccg cttgtggccg
     8041 tggaaggaca gcaccagtga gatcggcgtg gcctgccggt agttctccgg cacgtgcacc
     8101 aggtagctgc gggtgatacc accggagacg atcgtccggg tctgcgagta gccgggcgcc
     8161 accgcggacg ccttaccaca gccggtggac ggcacggggt ggtcggtcac gcgagccggt
     8221 tcggcctgcg cgggcaagcc acccagcgtc atggccacgc cgaccgcgac cagtaaccgt
     8281 ccacttcgga tcaaacggga cgagtggcgg gcgaacaccc gcttcgcgcg gccaggcacc
     8341 attgcctccc acctcgatca actcgggtgc aaggatcatg gacctccgaa gcccgccggt
     8401 cagcattgcg tacattgcgt tcacacgtca cgcgaagggc gcggcgttgc gcaccgccca
     8461 ctcggtgaag atgcgggcag cgagcgaaga cccgctcgac gtccggactc acctgctgct
     8521 cagcggcttt cgggctcgcc caggatgccg agggggactt cgagggaatt ctgggcaagg
     8581 tcgagcaagc ccgcgcgaac tacgaagccg cgcagcggac ccgcccccgc cggcagcccc
     8641 ggctgcggcg cgtttcaaac gggcggggag aggcgccctt cacttcaaag cccaccgcca
     8701 tacgctgcgc agacgctttt tgttctggtc acagcgggtc tttagaccct gcttagtcta
     8761 gtacttggcc ggtggttgat cggtaatcta tttatgctgg tgagggcttt gcccagatca
     8821 cgaacatgga cgcctgatta gcgagaaccc ccggcgcaag cgggcgcgcc ggggttcagc
     8881 tgcggagggt ttcgacgcgg acgccgacac tggtcgatca ggcgcggaag atcacgatgg
     8941 cggccagact cgacatgaat ccgccgcatt ctggtcatat gtcaggacga gcctgctgtg
     9001 cgtcttgtcg atggcaggag cgatgaggtc gccatcgggt gtgtcgactg gataggcgat
     9061 caccacaggg cgctggtctc gcgctgagga ccaggctcgg atctcgtcgc acaggtgctc
     9121 aaccagctct gcggcagctg ggccgtgtcc gatcgcgccc agttcccaac gcgtcccttg
     9181 atcggtgttc tggcgtcggg ttgtgaggta tgccagcgat tcaccgtcga ccagtgccgg
     9241 ggaccgcagc gcggcgatcg ggtcgcaccg ttcgggtgag acctcgggga gagcgttgat
     9301 tcggcacgta cgtgcgtcgg tcacggtgag ccgcagccag attccgtcat gcggctcatc
     9361 cccagcgatc gtgaccgcgg accaggctgt cgttcgtggc tggtcgagca ccccgtggag
     9421 cacttctggg tccacagact gatcacgatc ccaatgcaag ctgactgcct tgtcctccgt
     9481 gatgggagcg gttcgctccc cctcgtcatc gccgacaagg tagacgaacc cgcacagttc
     9541 cacggagtcc gagacgaggc atccgtcctg atagctgaag gcaacgctgc gagcctgccc
     9601 gcgccaccgc aacggcacca ccatgcgccc acctggggcg agctgatcca ccaagattct
     9661 gggatatccc acggactcac ggtggcgatg agccggtcat agcgcgcgtg ctcgggtaca
     9721 ccggccgccc catcccctgt gacgacacgg acaccgccgt atccggcggc ttccaatcca
     9781 cgcgacgcct ggtcggtcac gtccgcatcg acgtcaatcg tcgtcacgtt ctcggcagcg
     9841 ccggtcaact ccgacaggag cgcggcgttg tagccggtgc ctgctccgat ctccagcacg
     9901 cggtcacccg gtcggacatc gagctgatcc agcatcatcg cgacgacgaa cggagcggat
     9961 gcgcaggaca acgacgtccc gtcctcgaag cggtgtgtga tcactgcttt ccaggggtgg
    10021 taggcgtcct cgatgtcggc ttcggggacg aactcatggc gcggcacttc gcgcaggacg
    10081 cgctctgagg ggcctcgaag atcccggaca gggacccaat agggttaccc tgcaagggaa
    10141 tcgagggaag atctagtggc accaccgagc aagtactcgc cagagttccg cgaagaagcg
    10201 gtccagctgg ccctggaatc cagcaaatcg cacgttccat ttcctttgcc acctgtgccg
    10261 ggatttcgac gtgggcgtca agtcgaagat caatggccag gggtacacgc accgaatccg
    10321 cgatgttccg catcctggcc acgatgcgct cgcgtgcttc ctcggttggt gcgtcgttgt
    10381 gcgccctgat ctctccacga atctcctcaa gctcacggac caacggcgca accggggacg
    10441 tttcggcatt cacctcccgc agcttgccca ggatgtaccc gaatgggtct gtgatcgtgg
    10501 acggagcgcg caacgcggta agcagaaacc cgttccgcac caacgagatg agcatcccac
    10561 gcggatctcc tgcacctgga aaggagcgga caagtctgtc ggccaggaca tcgaaccgga
    10621 tcggcgaagt ggccgcgtcc cggaccttca acaccgcgcc ggatttgcgg acgctgatct
    10681 tgtcttggcc aggcagctcc agccgcgcgc cgcgcaactc agtcgagctg ttgaagatga
    10741 catcgagtcg tcctaacagc tccacgcagc cttcgaggcg ttcgatcacc tggtgcagcc
    10801 atcggttatc cgcgtgcgct accggcctgt ggctcgctcc ccactgcgcc ttcgtcgttg
    10861 ctcccaccga ggcagtgctg accccggcga acatcccgaa cggcgtcgac cgacctgtga
    10921 atcgcagtgc gtagcggacc accgccagag ccgcccgttg aacgttccgt gccgaaacgc
    10981 tctcttcggc aaggatggac tcggtctgag cggcaagaac ggggctcgca tgccggattg
    11041 caggagccaa tccaggcaga gtccacgtct gtctcagcca ttcccgacac tcttgctcgt
    11101 cagccggatt gggccaccag tggggttctg caatcccagc tgccgccctc agcagcccgg
    11161 tcccgtggtg ttggtagtcc tctcgggcag gcatgcccgc acctccgacg gatatagcct
    11221 ggggccgggt tcgtacccgg ccccaggtct gagtcacctc tgggagagac aagccgatat
    11281 ctcgcaggtg tgcccacaac cgtcgtcggt ctggcacgct gcttcctgcg gtcgcacctg
    11341 ctccgtctcg acctgaagat caaggtcgaa gacgtcctcc gaggtgtcgc caatagcctg
    11401 ctgggggccg agaatggcag tcatcgctcg ctttacctcc ttcctattca acaattggtc
    11461 tcactggttt ccgccgggca tggtacgggt ttgcccggtg gtctctgggg ttcatgccgt
    11521 gagttcgtcc tcctgctcgt tggagggcca ctcgatcggc tcaggttccc ggagcgctag
    11581 gcacgttggc gcgtgaaagc gccgactgga agctcaaaaa ctcgcgatca gcgtttggat
    11641 cagtatcttg ccagcgactg agaaaatcac cgtggtcctc gcacgaagga caggtgccgg
    11701 attaggctgc gggttccggc tagctcgaac gcttcagcca gcccgagcgc tattgccaca
    11761 ctgcggtcgt ggcctccttg gcaccctagc gcgacggtga ccaacggatt gccttgtttc
    11821 tcagcggcgg tgaccatcgg accgaggaca ttgagcaggt cttcaaacca actccgcaca
    11881 ttctcctgcg caaacaccca gtcctgcacc ggcttgtcca gcccggacaa gtcgtgcagt
    11941 tccggacgat gcacggattg ggaatccacc gcacatcaac cgcgaggttc gccggcggga
    12001 ccggcgtgcg gttgaagccc cacgtgagca cctgcaacac agtcatccga tcacccgcca
    12061 gaccccggag acccagccgt tgaaatcggc catcatgtag taaacggcct ggtcaatgct
    12121 tccgtaccgc attcgtgctt ccacgaccgg aatcgcaagt aagaccccag tgatgagaat
    12181 agcgagtgtt ttgacgcgca cagttcccct acagcatatt cttgtacgta tccaattttt
    12241 cgcggcatgg ccaaatgttt ccgtgaagcc gctttatttg ctcgatgatg tcctcgtatg
    12301 tggttgccac atacccgatt tcgtcgtttt ggctgccctg cgtcgtctgg atcagcgagt
    12361 gcagcgcttc cgaaaggtgg tcagcggcct gtgccagggc ttgctgggtg tcctgcgcca
    12421 gttgatcggc ggtggtgata cctgcctgga tgtctcccac ggccgacacg tgctacatcc
    12481 ggcccgcgta gctctcggta gtggaaacca gcgcctgctg cgcctcgtcg aacaccaggt
    12541 tcgtgtgctg acgggcggtg ccctcctgca ttttcttgtt ggcctgcgca attcttgcac
    12601 ggacctcttc cattcctggc atcggttttc tttctgttgt ggtgcggacc gacggtgccc
    12661 cggcgcgcgg agtccggttg cggcgcgtct gccgcgcgtc gaacctcacc agccaccaaa
    12721 ggtgagtcgg ccgggtggct gacgcgcgcc ggggccctgg gagctggccg ggcagttgga
    12781 acgtcactcg acctgccctg ccagcgggtt acagttgcgg cccgacccct ggccagtgcg
    12841 ccacgcagtt cgagtcgtag tagggcgtca tgtcctcgcc gctgtcttcc tggtcgtcgg
    12901 tttcgggctc ggggttgtcc ggcatcagtc gcctcctttc gatgtccaca gtggtcactg
    12961 gacccgcagc gtcgttgagg cggagggttg gaacccgccg gggtgatgca ccgaggggcg
    13021 gcgcaccatc ccggacgggg acggctcggt gccggtcggg ggtcacgaca ccgagccggg
    13081 tctacaggcg ttgcagggcg tcaagaagcc gccgaagcat cccggggtgg cgggccaacg
    13141 cctcgcgatc gccgaccggt agaccggact cgaccaccgg cagaaaccgg gtttcctcga
    13201 cagcgagcgc atcggccaag tccccgcgca gctgcaccgt ccgcggctcc cgcaagcagt
    13261 gccgaccgcc gctggtctct gcctcgaccc gcgcaaccag gtgcgccacc gtcagcgcac
    13321 cttcaccgcc accagcgtgc cgtgctggcg cgtagtagaa cgtcgccgac agcgccaacg
    13381 cgccgacaca gagcagccca gccgcgatcc acgccgcgat cacgttccca cctcgtttcg
    13441 ggccatcggc cttacctcgg tctgattgag gggcggcagg cggcgcgcgg agcctgggag
    13501 tctcgccagc tccgttgtgc tcgacgctgc gccgcccgcc ccatgtgccc gcccccaaag
    13561 ccgtcgtcac cggccgacgg ctttgccgtg ctaggggcgg ggaaggtcac tgggcagtgc
    13621 tcaaaatcgc atcgtgagcg cgaaatagag cacgcataaa tgaaaaagaa gcaaagcacc
    13681 ggacgcccac gcgacgagaa ttctcagcag accccgcagc cctgcggcta tgacgcatcc
    13741 gccgaccgag gcggtgatgc cgtataccgc gagggcggct gcggtgagcg ccaacgcaaa
    13801 ccgttcggcg ccgccgcgat tcattcggtc caaagcaccg ccaacgaacc tgctggcctc
    13861 gacccagccc aggattccca gcagcaccag cggccagccg atgacctggg cacccgcacg
    13921 gagccatacc gcgctttgag tgctgcttgc cttttcaggc atgctcacgc ggccccgcct
    13981 tgtgacgagc ggtttgaacg gcggcgatgt gcacgccgag cgcgaggtac agcttttgcg
    14041 cctgggtctc gtcgagcaac cgctcctctg ggccgacccg cagccacacc gccgttgagg
    14101 cgtgactgac cacgacgtcg cagtctcgcg aggctcgatc acgacacggc actgtcgtta
    14161 gcgttgtcat gctttcctcc ctggaaacgg ccgggatgcc agacggggca cggcaccccg
    14221 gccgaggttt ggaccttccc gcgccgcgac ggaccagaag acgacgcggg gaggctgctc
    14281 ggccggcggc tgcgcctcgg caccctgtga ggtccgaccg gaaccaccag ccgagcggtc
    14341 gtggaagctc agatccgccc ctaactggtc agttccggcg cttcccttga gcgcaaggtt
    14401 atggatcaat cacacggtgt gactggtact gaactggtac tcgtacactc gggatggcct
    14461 gatgtagatc agccccgtgg aaggggaaca acatgagcgc gaccaccccc gacatcggcc
    14521 agcgcatcgc caccgcgcgc aagctcgctg gcctgaccca gttccaactc gccgagaaag
    14581 cgaattactc cgaggcgatg gtgcaggccg ttgagcaggg caagaagcca gcaagccccc
    14641 ggtttatcgc ctcggcggcc aaggcgttga gcatcgagcc ggagcttctg accgggcagc
    14701 cgtaccactt cgacaacgag aagccgctgg agggacttcc cgagctgcgg gcgctgatcg
    14761 ccgaggggac ggaagtgatc gtcgcgccac cagcaccgct gagcgaactc gaagccgacc
    14821 tggcgcagat ctcgaagtgg tactgggacg acaagggcgc gaagtcgctc gcggcgatcc
    14881 caacgttcct acggcaggtc tacggcgcgg cgcacgcggc gaactcggtc cacgacaggg
    14941 ggcgggccta cactctgctg tccgccgggt gggctcaggc cgagcagttg agtcgccggt
    15001 tcggggcact gactctctcg gtgccatgcc tggaccgact ggacgcggtg gcccagcacg
    15061 ccgacgaccc ggtgtacgca gcaaaggcca cacagaagcg ggcacgggtg ctcatgtact
    15121 acggcacgtt cgactccggc cgtgccgctc ggtccgctga acgcctggcg gagctgccgg
    15181 acagcgagcc gatcctggcg gcgcgaggct cggcgcatct atgcaccgcg atcgtcgcgg
    15241 cgcgcggcgg ggatcggccg accgcccggg cccatcttcg ggaggcgcgc gaactcggcg
    15301 cgcgggttgg gcacgagtcg ccacactacg gtacaaagtt cggaccgggg aacgtgacca
    15361 tccacgaggt cgcagtggcg ctggaggcgg gcgacccaga gcaggccgca cgcctcggct
    15421 cgtcgacccg gctcccggcc gacgtctcca gtccgcggct tgcccaccac tggcaggacg
    15481 tggcgcgggc gtggctgctg tcgggtgatc cggcacgatc gctgcaagcg ctgaacatgg
    15541 cgcggaaggt ggcaccccag cagacgcgac ggcacccgca ggtgcgcgag acggtacgca
    15601 tgatcgctga ggccgagcgg cggaggaccg acagcctgac cgcgtttacc agttggcttg
    15661 gaacccctgc gtaggcatct tgtccacacg tgcccgctgc aacgggtgtg acggtcagca
    15721 agcacagctc acatcattgg cgcacaaaga aaatccccgg tctgtccaac ttggccagac
    15781 cggggattct tggtccctta cggaatgatc gccatagggg gagcgtagga gtgctgtcag
    15841 ggcagcgggt catcccctct ttgccagact gatgtgagac acctcgtgtg agtgcggggt
    15901 tcctgaccga gggcgggatc ggagatcctg gtgcacgtgt ccacaccatc tgacaagcag
    15961 cccgacccgt caccgctggc gggtccgggc gacccacggg cctcagtcct tggtagaccg
    16021 agtacggccg gaactcatac cggatgtggg agcgtgccgc ggcccagtcc agcagccgtt
    16081 ggaagccgga gacgcgctcg acgcggtcga ggtggccgga gtcgatgaga tcgccgacgg
    16141 tacgggtgta ggtctcgccg tcgatctcca ccgtttcgcc gggggcgttt tccaaggcgt
    16201 cgaagatgac ggtggccgga aggttcagtt gctcggcggc gtgggcggtg agggcgaaga
    16261 cggtgagcac tgtgactacg gtgcccaggt gaggtgtgcc gttgagctgg gccgcggtgg
    16321 tgacccgtag ccgctgccgc ccgcgggcgg cagaacgcag caggtcggtg ttgtcacggg
    16381 tgaggtgcgc gatccccacc ggagcaaaaa tcagttcgtt tggtgtcggc tggttcgtag
    16441 tgctgatcgc gggcatggtg tcttccttcc gatgtagatc cacacggcgg tgaaatcggg
    16501 atcggggatc cggatccgtt tgagcagcag caggtgcact ccagcgcggg tagcggcggt
    16561 ggtgtagagc tgcctggtca gctcgactcg gctcggggcg tggcgggcga cccagttcgc
    16621 tccacctacc cacccgccgg gtgccagcag gcggtgaatg tgggcgaagc tggttgtgaa
    16681 gtggttggcg tcgcggcaca aaccgagcaa gccgaactgg gtgaccaggt tgaatgactg
    16741 tccgatgagc ctcgggtccg tcggtggcag gctcgagaga aagtcggctt ggatgagcgc
    16801 ggtcagggat cggcagcgtg cttcgaaggc atctgggtcg gtgcgtccgc ataattccag
    16861 tgcggtgacg tggatacctc gtggctgggc ggtggtaacg aactgccgga ggatctccag
    16921 gcgctgtgtg tcgatgtcga ccgcgacgag gcgctgggcg cgcagggcgg tggcccatag
    16981 catcgattcg gatccgcacc cgagatcagc ccatgtcgtc acgggcggga tctgcatcaa
    17041 tgccgcgagg atgtcctcgg tgccgaggcc gaagcggaac tgctcggcgt agtagcgccg
    17101 ccagtactcc tgtgctcccg ccacggttcc ttcgctgttc acggcttagc cccggccgca
    17161 gccagaacct cggacatccc gtcctggccg ggcaggaatc gcacacgacc gaatcccgca
    17221 gtggtaaacg catcgcggag gtcggcggcg ttgaacagcg ccaactcgat ggccgtggcg
    17281 tgcaggctgg accctgccgg gctgcggtag tcgaactgga tctgcagccg ttcgccgtgg
    17341 cggtgctggc gtcggcgccg tagcaccgcc ccgccggcct gctcggggtg aaaccaccgg
    17401 tcggcgaacc acacgccgtg ctgacgggcg gggtcgtaga agcccgccgt gtcgactccg
    17461 ccgccagggt ggacacaggc cacctgcgcc agcaccaccg cccagggcgc gacagcggcc
    17521 cgtaacacca tgagcagctc gacaagagcg gtttggcacg caagttggtt gagcgcggcg
    17581 ttcgggacga cgatcaggcc cacgctggtc agatccggtg gctgctggac ataagccagg
    17641 tggcggcgtg ttttctcatc agataggcca ctgtgcacgg cgttttccgt ggcggcggcg
    17701 agcatcgcgg cactggcatc cacgagggtc accgccagtg ctgaccgggc gtagtcggca
    17761 aggaaatgac cagcgccaca tgggatttcc gcgacatgat cgaccgctgg gagcaagccg
    17821 cgcaacagcc gtgggcgtgc gaggtgcgct gtctcggcgc gggcgaacgc ggctcgccgc
    17881 tggtaggact cgatgacggc ctcggtgccg gtgccggtgc cggtagtggt cacgaggcga
    17941 ctccgaagta cgcggcgtgt tcgcggcaga ccgggtgcac cagctccccg tcgtgggcga
    18001 ttcgcgccgt cgccaccgcg gggtcggcgt caccgaaaag gacgacccgg gccagacgta
    18061 ccaggtaggg cagagcgttg gtcgtgtacg cctgggtcgc ggtcaccggc accagcgcgg
    18121 ggagcgcgtc gagtttgatg tgcagcaccc cgtggaccac gcgcggtggt tcaccgggct
    18181 cctgcacccc tccggcggtc ggcaggtagc cgtcgccgta accacaggtg gcgtcaacga
    18241 tgaccgagcc gggtttcatg tcctgcaggt ccgcttcgct gatcatcgac ggggtgtcga
    18301 aagtggacac caggattgcg ccgatgacca gatcagcctg ggagatcagt tcccggcgaa
    18361 tccgtgcggt gttgaccgct acccgtaccc cggtgggggc gtgcggccgg tattcatccg
    18421 ccgatccttc gcaccgagtc agcacggtca ccctggcacc taaagcggcg gcggtgcgtg
    18481 cggcggccga gccgacgttg ccggagccga tcacgaccac cgtggccgga cggcgcctgc
    18541 gacctcggcg agaaggacac cgcgcccgct gaattcctgg agcgcctgcg cgccgcgtag
    18601 agcggcttgg atcccggcga tctgcccgcc cggggcggcc agcgggaacc gaccgtgctc
    18661 ggcaaggaac tcgtagctgt aggccgagat cttgctgtcc atgagtgcgg agagcatggc
    18721 agggttgcta cgcgacaaga tcatccacac cggccctgac cagcagcgaa acgtgacgag
    18781 accgtttgga gtgaaaggtg cccttcaccc cggaagaatc agccttcggc ggcgagttgg
    18841 ccgcaggccg ccgcgatctc ctggcctcgg gtgtcccgga ccgtgcacgg gacacccgct
    18901 tcacgaaccc ggcggacgaa ctcccgctcc accggcttcg ggctggcgtc ccacttgctg
    18961 cccggcgtcg ggttcagcgg gatcaggttg acgtgcgcga acggcccgag gtggcggtgc
    19021 agcagcttgc cgaggagatc cgcgcgccac ggctggtcgt tgatgtcgcg gatcagcgca
    19081 tactcgatcg acacccggcg cccggtgtgg tcggcgtagc cgcgggccgc ctccagcacc
    19141 tccgcgacct tccagcggtt gttcaccggc accagcgtgt cgcgcagctc gtcgtccggg
    19201 gtgtgcagcg acaccgcgag cgtgacgtgc aggttctccg cggtcatctt cttgatggcg
    19261 ggcgccagcc cgaccgtgga cacggtgacg gaccgctgtg agaggcccag tccctccggc
    19321 gccgggtcgc agatccggtg caccgcgttg atcacccgcc ggtagttggc cagcggctca
    19381 cccatgccca tgaacacgac gttggacagc cgaccgggcc cgccctggac ctcgccgtcg
    19441 cgcatcgccg ccgcggcaga acgcacctgg tcgacgatct ccgcggtcga caggttgcgc
    19501 tgcagcccgc cctgcccggt ggcgcagaac gggcacgcca tcccgcagcc ggcctggctc
    19561 gaaatgcaca cggtcgcgcg gtccgggtac cgcatcagca cgctttccag cagcgtgccg
    19621 tcgtgcgcgc gccagagcgt cttgcgggtg gtgccgtcat cggtgttcag gtgccggacc
    19681 gggttcagca gcggcggcag caggtgctcg gcgagcttcg cgcggctggc cgccgggatg
    19741 tcggtcatcg actcgacgtc ggcgttgagc ctgccgaagt agtggtgcgc gagctgcttg
    19801 gcgcggaacg gcttctcccc cagctcggtc accgcggcgc gccgttcgtc ggcggagaga
    19861 tcggcgaggt gccgcggcgg catgccacgg cgcggggcat cgaagacgag cggaagggaa
    19921 gtcgcagaca tagcgcccac cagtgtccca cggcgcggaa cgaccttggc ggccgggcga
    19981 tgccatgcgg acacgcgagg cacacgcttc gttcatcggc tggcggtcgc ccgtatcgtg
    20041 aaagtatgac gagtatggcc gagcgcccct cgccgtccgt cgaggactac ctgcgggcga
    20101 tctacgggct cagcgaacgg ggcgtgcccg tcacgaacgc caccctgacc cagcggctcg
    20161 gcctgagccc ttcgtcggtg tccgggatga tcaacaagct ggcgcagctc ggcctggtca
    20221 cccacgtccg ctaccgcagc gtcgagctga ccccggaggg ccgccggctg gcctgcgacg
    20281 tgctgcgccg gcaccggctg atcgagctgt tcctggtcgt ggagctcgac tacagctggg
    20341 acgaggtgca ccgggaggcc gacgcgctgg agcacgcggt gtccgacgaa ctggtcgcgc
    20401 acatcgccgc caagctcggc aaccccaccc gtgatccgca cggcgacccg atcccgactg
    20461 ccgaaggcac cgtggagaaa cccgcgacgc tgctgctgga ccaggtcgag cccggcacga
    20521 tcggcaccat cgcgcgggtt tgggacaccg attcggagct gcttcgctac ctcaccgaac
    20581 acagcatgac actgggctcg cggatcgaga tcgtggagcg caagcccttc ggcgggccgc
    20641 tggtggtgcg cgtcggcgag ccgccgcagg acgaaaccca cttcgtgggc aacgagatcg
    20701 cggcggcgct atcgatcagc gtgcaccggt gaccgttcac gaaacgtgtg aaagcgtgtc
    20761 gtgagtcggc accttgcggt gtcgacgttg gcccgcgctg ttcggtgcgg gtcttcccgt
    20821 ggcgatatcc gctgcccgcg tggtgcgggt cttgtgtggg tttccatcgg gctcgttttc
    20881 cgtcgccccg caactcgggg aggacgtcgt ggcgtcaacc aggttggcga ggttttgggc
    20941 cgcgtcgagg tcgcgatcca tgctcatccc gcaggacggg caggtgaaga tacggtcgga
    21001 caggtgcagc ttggttctca ccgcaccaca gtccgagcac gttttagagc tgggatccca
    21061 ccggtacgcg atgtgcacgc gcagcccggc ccaggaggct ttgtactcga cctggcgtcg
    21121 gagttcggcc atgccgacac ccgcgacctg ccgcgccagg cggcggttgc gggtcatgcc
    21181 cgcaacgttg aggt
//
