LOCUS       NZ_CP040605            22073 bp    DNA     circular CON 25-AUG-2024
DEFINITION  Saccharopolyspora sp. ASAGF58 chromosome, complete genome.
ACCESSION   NZ_CP040605
VERSION     NZ_CP040605.1
KEYWORDS    RefSeq.
SOURCE      Saccharopolyspora sp. ASAGF58
  ORGANISM  Saccharopolyspora sp. ASAGF58
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (bases 1 to 8045912)
  AUTHORS   Guo,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-APR-2019) Grain Processing Research Group, Academy of
            National Food and Strategic Reserves Administration, Baiwanzhuang,
            Beijing 100037, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.15x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012277335.1-RS_2024_08_25
            Annotation Date                   :: 08/25/2024 04:20:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,606
            CDSs (total)                      :: 7,535
            Genes (coding)                    :: 7,265
            CDSs (with protein)               :: 7,265
            Genes (RNA)                       :: 71
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 270
            CDSs (without protein)            :: 270
            Pseudo Genes (ambiguous residues) :: 0 of 270
            Pseudo Genes (frameshifted)       :: 80 of 270
            Pseudo Genes (incomplete)         :: 228 of 270
            Pseudo Genes (internal stop)      :: 14 of 270
            Pseudo Genes (multiple problems)  :: 48 of 270
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:54:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 183768
            Orig. end                         :: 205841
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040605.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22073
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22073
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22073
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12073](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12073
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            1180..2010
                     /locus_tag="FDZ84_RS00540"
                     /old_locus_tag="FDZ84_00570"
     CDS             1180..2010
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021778.5"
                     /locus_tag="FDZ84_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00570"
                     /product="YncE family protein"
                     /protein_id="WP_246868712.1"
                     /transl_table=11
                     /translation="MRKRLRRIPGSAALHRGDGHRESANGWTSIAPPPRRAHHVPGTPQ
                     RGPQYLHRARAVGIHLRRKGNSERNAHTWAQLDATRVPECAGIDHADFSPDGRTAVFTC
                     EFAGAVVVLDVSSHKVLRVLPMPRRHTRMGPQDIKLAPDGSVYYIADSDANGLWVLDVA
                     ATKVLRFISTGVGAHGLYLSRDAQQLYVSNRHEGSVSVLDARTGAAITKWRIPGGGSPD
                     MGNTTADGSTTARPPAATRTTRRFSKSAVEICRRLSLRVVPGSRFLGQCSPTVV"
     gene            2115..2573
                     /locus_tag="FDZ84_RS00545"
     CDS             2115..2573
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012859.5"
                     /locus_tag="FDZ84_RS00545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_246869283.1"
                     /transl_table=11
                     /translation="MSHWTLAALGALCLSGSVALPLAAAAPAPRETPLHNVADDGCLYS
                     SDGYGVALAECNPSSASQNWSREYLGNAELLRVNGTNSCLGQVDGPNVRLSACDSYDRT
                     QQWRIEPADSGSLIWHPATNSCLGNLGQEQVRLFSCDPSNPAQQWEMR"
     gene            3222..3947
                     /locus_tag="FDZ84_RS00550"
                     /old_locus_tag="FDZ84_00580"
     CDS             3222..3947
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696847.1"
                     /locus_tag="FDZ84_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00580"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_168584228.1"
                     /transl_table=11
                     /translation="MGADEAAWGRPELATNVNFREHREHLVRHGTGEVFRYIYRHNLWG
                     SRESVSGQGSEDAATARLRAEIPALLRRRGVRSIADVPCGDFGWLSRSELGVDSYFGGD
                     IVPELIEHNRKSYARPSRRFGVLNLTRDPLPTADLVLCRDCLVHLAFEQIWAALRNIRA
                     SGATYLLITTFPELRVNVDVETGDWRPLNFQLAPFGFPAPAELITEGCREGAGRYADKA
                     LGLWEVAALSDILEQPATS"
     gene            complement(4296..4718)
                     /locus_tag="FDZ84_RS00555"
                     /old_locus_tag="FDZ84_00585"
     CDS             complement(4296..4718)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696849.1"
                     /locus_tag="FDZ84_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00585"
                     /product="SPW repeat protein"
                     /protein_id="WP_168584229.1"
                     /transl_table=11
                     /translation="MTSQQIPIAGHPDLTELRSRYEHIAETPIAQAAYGLMVLAGLYVA
                     LSPWIVGFAGMSPLAVNNLIIGLTVAGLAVGYASAFGRLHGVAWLVPALGVWTIIAEWV
                     MSGAVATMPVVISNVVSGAIVVLLGIAAAGLVLQHR"
     misc_feature    4778..4792
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.06"
                     /tool="antismash"
     gene            4794..5288
                     /locus_tag="FDZ84_RS00560"
                     /old_locus_tag="FDZ84_00590"
     CDS             4794..5288
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013231.5"
                     /locus_tag="FDZ84_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00590"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_168584230.1"
                     /transl_table=11
                     /translation="MKSSPSRDAAPRKRHADAIDAFEAATRMLVGLATRSLAGETVTLP
                     QFRLLAALADRGPLPSSRAAAALGLNASSVTRLGDRLELVGLLSRTREPGNRSVVTLGL
                     TAAGGELVHRVLTSRRETLSRLLGQLDPRDVDGAAKALWRLTKLAAADEALGDLVPYPH
                     G"
     misc_feature    complement(5306..5318)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.62"
                     /tool="antismash"
     gene            <5330..>5770
                     /locus_tag="FDZ84_RS00565"
                     /old_locus_tag="FDZ84_00595"
                     /pseudo=""
     CDS             5330..>5770
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223921.1"
                     /locus_tag="FDZ84_RS00565"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="FDZ84_00595"
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTAVLVVTFGRLGDMIGRVRMYNAGFAVFTVFSVLLSVTWMQGTA
                     GALWLIGMRVLQGVGGAMLMANSSAILTDVFPVQQRGLALGLNQVAGLAGSFIGLILGG
                     LLAPVQWHLVFLASVPVGLFGTCWAYWKLRDTGTTEHSRPDWW"
     gene            5947..6117
                     /locus_tag="FDZ84_RS38440"
     CDS             5947..6117
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS38440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_168584231.1"
                     /transl_table=11
                     /translation="MAAIASWLRGGKYVYAEPPEPVPPRTVPPARQEEAAVPGPAPIGL
                     QQPDPPRAASE"
     gene            6618..7079
                     /locus_tag="FDZ84_RS00575"
                     /old_locus_tag="FDZ84_00600"
     CDS             6618..7079
                     /GO_process="GO:1901661 - quinone metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010242305.1"
                     /locus_tag="FDZ84_RS00575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00600"
                     /product="MSMEG_3727 family PQQ-associated protein"
                     /protein_id="WP_168584232.1"
                     /transl_table=11
                     /translation="MATAEDLSALVSKLGLDKQNKATLGRLIAHGNLGYAEEGADGRMH
                     AQIRIPPDELVWDPAILVLPHGGDLELEIFNDDQNTHCALFPSNGDSQFIWLPIHSRGT
                     AALNLDGPGYYWYSSPIGNDEGRGLIGAIVVLGDAPQQARLDRPDQPRP"
     gene            7093..8778
                     /locus_tag="FDZ84_RS00580"
                     /old_locus_tag="FDZ84_00605"
     CDS             7093..8778
                     /EC_number="1.1.2.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241631.1"
                     /locus_tag="FDZ84_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00605"
                     /product="PQQ-dependent dehydrogenase, methanol/ethanol
                     family"
                     /protein_id="WP_168584233.1"
                     /transl_table=11
                     /translation="MTEYVDAGRAVGQASLSGLAGIAPPVVQDVTYERILQARSEPQNW
                     LTYYGAYDGQRYSPLDQINTENVKHLAPAWVFQSGSAGLHAGPSTYSFEAAPIVVDGIM
                     FVSGWDGFVWAIDGRTGQVMWRYKHAIPYDTSLCCGNVNRGVAVAKGKVFVVTLNAHVI
                     ALDATNGELVWDVTYGDVRAGESATVAPLVVKDMVVVGSSGGEFGVRGHLDAFELDTGR
                     HIWRCYTVPKPGERGSETWPDGPAWTRGGGNCWVTGTFDPELNLMYWGTGNPAPDFDGG
                     LREGDNLYTDSVIAVDPDNGEIRWHYQYNPHDLWDYDSTMEHILFELDGRKLLAHFDKN
                     GYFFVLDRTNGELVRVSPFVDRITWGEIDPNGKVTPKIYPEKEGEEVHFWPGPAGGKEW
                     THAAYSPRTQLCYVPVQDVGASVTRRRREFKESIPYWGASVTVDSDDMAGSVSAFDPSN
                     GNEVWRWRNDVPMCGSVLATGGDLVFAGEPTGEFNAFDARTGELLWQFQTGCGHHSSPT
                     AYSIDGRQYLAVPVGWGAWVEGFLPGMLGAPHGDALFAFALPQE"
     gene            8821..8964
                     /gene="pqqA"
                     /locus_tag="FDZ84_RS00585"
                     /old_locus_tag="FDZ84_00610"
     CDS             8821..8964
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696859.1"
                     /locus_tag="FDZ84_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00610"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_168584234.1"
                     /transl_table=11
                     /translation="MESVATRPTLEWESPEFAEVDWEPPEFEELQCTSEVTMYMYVARW
                     ED"
     gene            9108..10004
                     /gene="pqqB"
                     /locus_tag="FDZ84_RS00590"
                     /old_locus_tag="FDZ84_00615"
     CDS             9108..10004
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696861.1"
                     /locus_tag="FDZ84_RS00590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00615"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_168584235.1"
                     /transl_table=11
                     /translation="MWVRVLGSAAGGGFPQWNCACPNCRAVRDGSRPCRPRTQSAIAVS
                     GDYRKWFLFNASPDVRTQIEAFAALQPSGERATPLRAVLLTDAEIDHTLGMLLLREAKA
                     IELHATPAVQETLCDGTAVLRTLEAYCQVTWRPVVPGADVRLDGGLSYRAFDVPTSKPP
                     RFGAGREQGRVVGYRLTDESSGRAVVYLPGVQELTAEVLAELDDCGCLLVDGTCWHDDE
                     LIRLGLARKTARDMGHLPIGDPGGSLEQLSPLPIERKIYIHINNTNPILLDDAPERRAL
                     EQRGMEVAADGLEVRVA"
     gene            10001..10711
                     /gene="pqqC"
                     /locus_tag="FDZ84_RS00595"
                     /old_locus_tag="FDZ84_00620"
     CDS             10001..10711
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241625.1"
                     /locus_tag="FDZ84_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00620"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_168584236.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.1e-99, bitscore:
                     331.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLTDTGSFTAQLRAQSRRYHDQHPFHVKMNEGRLSRRQIRGWV
                     ANRFYYQANIPRKDAAILANCPDRGVRRRWVLRVLDHDGTAGDEGGIGAWLRLAEAVGL
                     AREEVLDERHLVPGVRFAVDAYVNFARTRPWVEAVASSLTELFAPDLMADRLAAFERRY
                     PWIDRDGLGYFRSRLAQAPRDAEHALQVVTEHCRSADEQARAVAALSFKCEVLWSILDA
                     IDQAFPDSGDAGTL"
     gene            10708..10989
                     /gene="pqqD"
                     /locus_tag="FDZ84_RS00600"
                     /old_locus_tag="FDZ84_00625"
     CDS             10708..10989
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696864.1"
                     /locus_tag="FDZ84_RS00600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00625"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_168584237.1"
                     /sec_met_domain="PqqD_RRE (E-value: 7.5e-20, bitscore:
                     69.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.9e-11, bitscore: 41.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAVESASRPRMASYVRLVFDQVRERHMLLAPESVSVLNPTGAA
                     VLGLCDGRRTVAEIVAELRGQSDHLACDEVLGFLSRLAAKRYVEVDDD"
     aSDomain        10717..10974
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FDZ84_RS00600_PqqD_RRE.1"
                     /evalue="2.80E-22"
                     /identifier="RREFam006.1"
                     /label="FDZ84_RS00600"
                     /locus_tag="FDZ84_RS00600"
                     /protein_end="89"
                     /protein_start="3"
                     /score="69.3"
                     /tool="antismash"
                     /translation="AVESASRPRMASYVRLVFDQVRERHMLLAPESVSVLNPTGAAVLG
                     LCDGRRTVAEIVAELRGQSDHLACDEVLGFLSRLAAKRYVE"
     gene            10982..12073
                     /gene="pqqE"
                     /locus_tag="FDZ84_RS00605"
                     /old_locus_tag="FDZ84_00630"
     CDS             10982..12073
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696866.1"
                     /locus_tag="FDZ84_RS00605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00630"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_168584238.1"
                     /sec_met_domain="PF04055 (E-value: 4.5e-23, bitscore: 81.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-06, bitscore: 26.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.1e-10, bitscore: 38.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.1e-09, bitscore:
                     35.5, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPFGLLAELTYACPLHCPYCSNPLNLADYGEELTTAQWQQVLT
                     EARELGVVQLHMSGGEPLQRRDVVEIARSANELGLYTNLITSAIGLSPRRAEQLRAAGL
                     DHVQISIQSHEATVSDSIAGTPSFERKVAAARLVKELGWPLTLNIVLHRMNIDRISDII
                     ALAERLHADRIELANTQYYGWALHNRSALLPSRKQIDRAAAVVRAANKRLEGKTTIIYI
                     LPDYYSQYPKPCMDGWGRRQLTVTPNGDVLPCPAAHTLPLPRASVREKSLAWIWAESPV
                     FQRFRGTDWMPEPCRSCPRREIDFGGCRCQAFLLTGDAARTDPVCILSPDHEIVADAVR
                     AANEETRPLAEALTPRPHPRDTR"
     misc_feature    complement(12321..12336)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            12355..12888
                     /locus_tag="FDZ84_RS00610"
                     /old_locus_tag="FDZ84_00635"
     CDS             12355..12888
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696889.1"
                     /locus_tag="FDZ84_RS00610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00635"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_168584239.1"
                     /transl_table=11
                     /translation="MGDVDARVVADELMTVIAALRRTVRRSLRAELPTPDLRGAQVELL
                     RVVEQQQGISVTAAALQLRMAANSVSTLVNQLARVGLLRRDTDPDDRRAIRLHLTDTAA
                     HRLAAWRQARTGLVGDALAELSTADQKAVAGALRGLHALVEALEGGGADDRADGRAMQG
                     SAARVRRPDRGRRG"
     gene            12812..13621
                     /locus_tag="FDZ84_RS00615"
                     /old_locus_tag="FDZ84_00640"
     CDS             12812..13621
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696890.1"
                     /locus_tag="FDZ84_RS00615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00640"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_168584240.1"
                     /transl_table=11
                     /translation="MTERMAVRCKGLRHAFGDQIAVDGVDLDVRPGEVFGLLGPNGAGK
                     TTTIRAITTLLPTRAGTVEVFGVDVARHKLAARRLIGYVPQQLSADGSLTGRENVALFA
                     RLFDVPRAQRRSVVRAALGAVGLADAAERLANTYSGGMVRRLELAQALVSGPKLLVLDE
                     PTIGLDPIGRESVWDRIREIRAETGMTVLVTTHYMDEADQHCERIALMHRGRIRARGTP
                     AELKAAVGPDATLDDVFRTISTDAFGAGTGEGMRDVRAARRTSSRLG"
     gene            13581..14402
                     /locus_tag="FDZ84_RS00620"
                     /old_locus_tag="FDZ84_00645"
     CDS             13581..14402
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101951.1"
                     /locus_tag="FDZ84_RS00620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00645"
                     /product="ABC transporter permease"
                     /protein_id="WP_168584241.1"
                     /transl_table=11
                     /translation="MSARLDVLPAASVEPVRRSLPGLLLARVAAMCLVELQKLRHDRTE
                     LLTRAIQPALWLLIFGEVFTRLRAIPTGNIPYLDYLAPGILAQSALFIAIFYGIQIIWE
                     RDAGVLAKLLVTPTPRVALVTGKAFAAGVRALVQALVVLMLAALLGVGLTANPVNLLAM
                     AVVVVLGSAFFCCLSITIAGLVLSRDRLMGIGQAITMPLFFASNALYPVDLMPEWLKVA
                     NYANPLGYEVDALRGLLIGTPAHLALDFAVLVVAAGTMISIASALLGRLAR"
     misc_feature    complement(14652..14670)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.7"
                     /tool="antismash"
     misc_feature    14653..14669
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: medium, score: 26.34"
                     /tool="antismash"
     gene            14713..15462
                     /locus_tag="FDZ84_RS00625"
                     /old_locus_tag="FDZ84_00650"
     CDS             14713..15462
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696892.1"
                     /locus_tag="FDZ84_RS00625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00650"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_168584242.1"
                     /transl_table=11
                     /translation="MSNNRRAALDAVRANWNRRAAGYDRFYRDYTQDKRDAWRAAYEKI
                     LGELFARRDEPLKVLDVGTGTGFLSTLLAELGHHVTAIDPSGAMLDYARAEADRRGVEV
                     RTIACGAHDVARLDTEFDLVTARYVLWTLPDPVAALRTWREVITPGGGLLLADGLWHTW
                     RHDGRRLAASLRPGGDHQFLWQLLHDYAQIGNATPHWAGLTLDRTRALFAAGGFQSGTR
                     HDQLLPEYAHPVSADFFILGTRPARLP"
     gene            complement(15559..17181)
                     /locus_tag="FDZ84_RS00630"
                     /old_locus_tag="FDZ84_00655"
     CDS             complement(15559..17181)
                     /EC_number="6.3.2.13"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF001126.0"
                     /locus_tag="FDZ84_RS00630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00655"
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="WP_168584243.1"
                     /transl_table=11
                     /translation="MVPRLGATVDVREVDGCDMECGCQHAGISLSKATRDLPGAELRGD
                     ADVLDVTDDSRCVRQGALFCAVPGTQRDGHAFVDDAVAAGASALLVKRFVDAPVPQVRV
                     PAVRPAVGPVAAAVHGYPADALAVAAVTGTDGKTTTVHLIEAALAAAGYRTGLVSTVEA
                     RMPGARSPAALTTPGAAELQRTLCRMRAEGVQAAGMEVSSHAVDQHRTDAVTADVAVFT
                     NLSPEHLDYHGTVEQYYATKAALFTPDCCRRAVINIDDSWGKRLAAQAKVPTVTVGRAG
                     QADVRVASTSDELRVVVQDGVDRVELATPAVGQAANLAAAYAAARLMGVSRRDAVVGLG
                     AAPPPGRYQRVDADQPFQVVVDFAHTPRALTQLIATARRASRGRVHLVVGSAGNRDRFN
                     RPDMGRVALTADSAIFTADDPHDEVPEEIIAQMLTGTIGRAGAAIVVERDRWKAITAAI
                     ERAEPGDVVLIAGRGHERYQTVEGIQHPFSDVAVAEAALADKGWSRRPAASRPNSAAPT
                     GVPRMRSAHPGWRRSGESRGECR"
     misc_feature    17353..17369
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 27.57"
                     /tool="antismash"
     misc_feature    complement(17354..17369)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 28.76"
                     /tool="antismash"
     gene            17423..17632
                     /locus_tag="FDZ84_RS00635"
                     /old_locus_tag="FDZ84_00660"
     CDS             17423..17632
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696894.1"
                     /locus_tag="FDZ84_RS00635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00660"
                     /product="heavy-metal-associated domain-containing protein"
                     /protein_id="WP_168584244.1"
                     /transl_table=11
                     /translation="MIEASYTVTGMTCDHCARSVTEEVSKINKVSGVSVSLPTGAVTVR
                     SSEPVNDADVRAAVEEAGYELAAR"
     misc_feature    complement(17665..17674)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            17877..20165
                     /locus_tag="FDZ84_RS00640"
                     /old_locus_tag="FDZ84_00665"
     CDS             17877..20165
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005447389.1"
                     /locus_tag="FDZ84_RS00640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00665"
                     /product="cation-translocating P-type ATPase"
                     /protein_id="WP_168584245.1"
                     /transl_table=11
                     /translation="MSTGTSPTAEIELAIGGMTCASCARRVERRLGKLEGVTATVNYAT
                     EKAKVAFPETLDLQQLVEQVEAAGYTAELPLEPAAEAEDPTKSLRNRLLHSAVLSAPVI
                     ALAMIPALQFTNWQWISLVIATPVVAWGAWPFHRAAWTNLRHGAATMDTLISLGTLAAY
                     AWSLYALLFGTAGTPGMTHGFELTIQRMGGDGNIYLEVAAGVTTFILAGRYFEVRSKRR
                     AGAALRALLELGAKDVAVLRDGVEVRIPTDRLAVGDRFVVRPGEKIATDGIIEEGSSAV
                     DASMLTGESVPVEVAAGDAVVGATVNAGGRLVVRATRIGADTQLAQMAKLVEDAQNGKA
                     AVQRLADRISAVFVPIVILLALGTLISWLATGAGAAAAFTAAVAVLIIACPCALGLATP
                     TALLVGTGRGAQLGILIKGPEVLESTRRIDTVVLDKTGTVTSGQMSLVAVHAADGIDEE
                     AVLRLAGAAEHASEHPIAKAIARGAAERVGELPAVEEFSNVEGLGVQAVIDGRAVLVGR
                     PALLAQWSRPLPAELVAAQTKVEKQGRTAVAVAWDGAARAVLAVADTVKPTSAAAIAGL
                     RKLGLKPVLLTGDNDTVARAVAAETGIDEVIAEVLPQDKVDAVKRLQSEGRVVAMVGDG
                     VNDAAALAQADLGLAMGTGTDVAIEAGDLTLVRGDLRAAVDAIRLSRRTLGTIKGNLFW
                     AFAYNVAALPLAAAGLLNPMIAGAAMAFSSVFVVGNSLRLRRFRSTSTTGPMPGTEASE
                     PVPAAARRD"
     gene            complement(20484..21413)
                     /locus_tag="FDZ84_RS39880"
                     /old_locus_tag="FDZ84_00670"
     CDS             complement(20484..21413)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.5"
                     /locus_tag="FDZ84_RS39880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FDZ84_00670"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_168584246.1"
                     /transl_table=11
                     /translation="MTNVRLSEGIILVEVAGELDVYTAPSLRERFVDALGGDEVRLVVD
                     LNGLDFLDSTGLGVLVGGLKRARARGGELIVVCSTERLLKIFRITGLTRVFRIVPDVAS
                     ARALLVDRAALAAQPDPDAETIGWHWVPGRIYLSDERDHQAVADAAERVVEAFGLEFAH
                     AFPPVVGSWFGEFLIRLKNSGQLPTKEEQFVKLSRALDLRLLDRQQAEVDAAQGAAVAG
                     LIQSLSNTPRAIVQIGSVLLVKVDEVVVVRNLTQLELAHWERNPALFRDPAAALQELQQ
                     ATSNGAGLEPAADAGEHETASSSRRSAD"
     misc_feature    21383..21397
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.72"
                     /tool="antismash"
     gene            21485..21652
                     /locus_tag="FDZ84_RS00650"
     CDS             21485..21652
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FDZ84_RS00650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_168584247.1"
                     /transl_table=11
                     /translation="MATRSTVFASRLADKSRDGTRCRGLLGLRRVLAEDGGAAPVGVTF
                     PELTRIRRTW"
ORIGIN
        1 gactgccatc gccgcaccgc ggatcgccag cgggaagatc tccgccagca ccacccacag
       61 caccggcccc caggtggcgg agaaggtgtt cgtgtacacc acgaacgcgg cgaccgcgat
      121 cccgaacagc gccggcgact cgggagacag gagcgacgcc gccgccccga ccgcgaacag
      181 gctcgccgac atgcccacca ggccgacgag caagacgggc ttgcgacccc agcgatccac
      241 gatcttgagc cgcaccacca ccgcgatcgt cgcgatgttc accagcccgt tcaggaacgt
      301 gaacagcagt gccgtgacgt cggaaacccc gaaggtcgtc agcacggtgg gcgcgtagta
      361 gacgatcgtg ttgattccgg tgatctgctg gaacacggcg agcagcgcgc ccagcacgag
      421 caggcggcgc acccacggcg cggacatgcg ggcaccgagc ctggcgtccc gctgctggcg
      481 ttcgagctcg gtgatctcgg cgagttcccg gtcggcggcg tcctggtcgc cgcgcaggcc
      541 gacgagcagc gtgcgtgccc gctcggggtg accccggcgg accagcgacc ggggcgtgtc
      601 cggtgcggcc agcaacccca ggaccagcac cgctgcgggg aacacgccga tgaggatcat
      661 ccagcgccac gaggcggaga aggccagcgc gtacccgcag gcggcggcca gcgccgtgcc
      721 cacgatgatc atgtactggt tcagcgaggt gatccagccg cggccaccgg cgggtgccat
      781 ctcggccagg tagagcggca ccaccaccga cgcgatgccg atccccagcc cgatgatgaa
      841 ccggaacagc accagcgtgg cgactgtcgg tgccacgccc gcgccgagcg ccccgatggt
      901 gaacaccacc ccggccgcga gcagcaggcg ctgccgtccc tgccagtcgg cggccggccc
      961 gctggccagc gctcccacca tcgctccgac gaccgtggca ctgaccacgg cgcccttgag
     1021 cagcggcgtc agcggcagct cgtgcgggat gaacaggatg gcggccgaga tgatcccgtt
     1081 gtcgtagccg aacaggatcg cggccagcga ccccagggcg tagacacgcc gcgtggcgag
     1141 ctcgggcttc ggcgacggcg ttcccatcga tcacctccga tgcggaaacg gctgcgccgc
     1201 attccgggtt cggctgctct ccatcgcggc gacgggcacc gggagagcgc aaacgggtgg
     1261 acgtcgatcg cgccgccccc tcggcgcgcc catcacgttc ctggtacccc gcagcgcggc
     1321 ccgcaatacc tgcaccgcgc tcgtgcggtt ggcatccacc tacggcgcaa gggaaactct
     1381 gagcgtaacg cgcacacctg ggcccagctg gacgccacgc gggtgccgga gtgcgccggg
     1441 atcgaccacg ccgacttctc ccccgacggc cgcacggcgg tgttcacctg cgaattcgcc
     1501 ggcgcggtgg tggtgctcga cgtgtcatcg cacaaggtgt tgcgggttct tccgatgccc
     1561 cgccggcaca cccgcatggg cccgcaggac atcaagctcg caccggacgg ctcggtgtac
     1621 tacatcgccg actcggacgc gaacggcttg tgggtactcg acgtggcggc gacgaaggtc
     1681 ctgcgcttca tctcgaccgg cgtgggcgcg cacgggctct acctctcccg ggatgcgcag
     1741 cagctctacg tcagcaaccg ccacgagggc agcgtcagcg tgctcgacgc ccgcaccggc
     1801 gcggccatca ccaagtggcg aatccccggc ggcggaagcc cggacatggg caacaccacc
     1861 gccgacggct ccaccaccgc tcggccgccc gcagcgacgc ggacgacgag acggttttcg
     1921 aagagtgccg tcgaaatctg ccgaaggctt tcgttgcggg ttgtacccgg ttcgcgcttc
     1981 ttgggccagt gctcgcccac agtggtgtga atcggggatt ttccgctggg atagcagtga
     2041 actcggtgac gcacgtgctc gaacgacgcg tgctacgtga atctagattc tacgaggtga
     2101 gttcattgcg taaagtgagc cactggaccc tggcggcatt gggcgcgctg tgcctaagcg
     2161 gctcggtcgc gctgccgctc gcggcggcgg cccccgcccc ccgggaaacc ccgctgcaca
     2221 acgtggccga tgacgggtgc ctgtacagct cggacggcta cggggtcgca ctggccgagt
     2281 gcaacccgag cagcgcgagc cagaactggt cccgcgagta cctcggcaac gcggagctgc
     2341 tccgggtcaa cggcacgaac agctgtctgg gccaggtcga cggccccaac gtgcgtcttt
     2401 ccgcgtgcga ctcctacgac aggacccagc agtggcggat cgagcccgcc gactcgggca
     2461 gcctgatctg gcacccggcc accaacagct gcctcggcaa cctcggccag gagcaggtgc
     2521 ggctgttcag ctgcgacccc tcgaacccgg cgcagcagtg ggagatgagg taacgagcca
     2581 cgcggggtcg ggtgtcctag ccggcgattt cgcgcgaaat cgccgctcac ccatctccgg
     2641 gtgaggtacc cgatccgagt ggtttccgag cgggcggggg cagccggtct ccgccccctt
     2701 cggacgccat cactcgaacg cctggcagag caggtgccga actgccagga cgtgaggtag
     2761 tcgcgctggc cagcggttag ctagtggagg gcatcgacag cgtcgtgcac acagccgcgc
     2821 tgcacgcgcc gcacgtcgaa catcttcccc gagcaggaat ttcgatcggt caacgtcgag
     2881 gcgaccgcga accccgcgcg gcccgggccg cgccccggtt ctaccgcggc ggcgaatcga
     2941 ccgggtctac gactccggcc gagcagccgc tagcctcggc tacaccccgg agcacggccc
     3001 cgattcgctg gccgagcgga agtagctttg agccgcggaa ctcgttgcct tagaacgcat
     3061 tggagccgaa gtcggctggt gggaccgtga tcaacggctt gcggccgcga cgatccgaga
     3121 tcaaccggcg ggcggtatgg gacaaccgaa atcgcgacca ccctgggtgt gcggggcgca
     3181 gtaccgatgc cgcgtgttcg cgcgacagga aggatgatgc gatgggcgcc gatgaggcgg
     3241 cgtggggacg tccggaactc gcaacgaacg tcaacttccg cgagcaccgc gagcacctcg
     3301 tccggcacgg aacgggcgag gtgttccgct acatctaccg gcacaacttg tggggcagcc
     3361 gggagtcggt gtccgggcag ggatcggagg acgccgccac ggcacgtctc cgcgctgaga
     3421 tcccggccct gttgcgccga cggggcgtgc ggtccatcgc cgacgtgccc tgcggggact
     3481 tcggttggct cagcaggagc gaactgggcg tggacagcta cttcggcggc gacatcgtcc
     3541 ccgaactcat cgagcacaac cggaagtcct atgcgcggcc atcgcggcgg ttcggggtcc
     3601 tgaacctgac ccgtgacccg ttgccgaccg cggatctggt gctgtgccgg gattgcctcg
     3661 tgcacctcgc cttcgagcag atctgggccg cgctgcgcaa catccgcgcc agcggagcga
     3721 cgtacttgct gatcacgacc ttcccggagc tgcgggtgaa cgtggacgtg gaaaccggcg
     3781 actggcgtcc gctcaacttc cagctggcgc cgttcgggtt ccccgccccg gccgagctca
     3841 tcaccgaagg ctgccgcgaa ggagccggaa ggtacgcgga caaggccctt ggactgtggg
     3901 aggtcgccgc cctgagcgac atcctcgaac aacctgcgac cagctgatca acgggcgtcg
     3961 agggcgatgt cgcccccgga tcggccactg gggcgcgatc gcgtggcggt agccggcggc
     4021 gaggaaggcg gaggccggcc ggggtgcacc gcttcgtcct gtaccgcctc gccggcgagt
     4081 tgggacccgg ggcgcgggct ctcgcgacag cacgcgcacc ccgtcacccg gggtgggcgc
     4141 aatttcgcgc gaaattgcgc ccaccccggg tgacggaacc cgggtccgcg tcgtcgggcg
     4201 cggtgttcag gactgcgcgc gggacgtggc gatcacggtg gtgaccaccg gcattcggat
     4261 gccggcggtc accgggagca ccgcttcgcc ggacttcagc gatgctgcag gaccaggccc
     4321 gcggccgcga tccccagcag caccacgatg gcgccgctga ccacgttgct gatcacgacc
     4381 ggcatcgtcg cgaccgcacc gctcatgacc cattccgcga tgatcgtcca caccccgagg
     4441 gcggggacca gccacgcgac gccgtgcagc cggccgaagg ccgaggcgta gccgaccgcc
     4501 agcccggcga cggtgagacc gatgatcagg ttgttgaccg cgagcgggct catgcccgcg
     4561 aagccgacga tccacggcga cagggcgacg tacagcccgg ccaaaaccat caagccgtac
     4621 gcggcctgcg cgatgggggt ctcggcgatg tgctcgtagc gggaccggag ctccgtcaga
     4681 tcggggtgtc ccgcgatggg aatctgctgg ctcgtcatga tgcacctccc aaataccttt
     4741 cggtgctaaa cccagcttga catgcagatt tgcggcatgc aagtcttgtt ctcatgaagt
     4801 cttcgccctc ccgggatgcc gcgcccagga agcgccacgc ggacgccatc gacgcgttcg
     4861 aagcggcgac gcgcatgttg gtggggctcg cgaccaggag cctggcgggc gaaaccgtga
     4921 cccttccgca gttccggctc ctcgcggcgc tcgcggacag aggaccgctt ccgtcttcgc
     4981 gggccgcggc cgccctggga ttgaacgcct catcggtgac gcgtctcggc gaccgcttgg
     5041 agctcgtcgg tctgctctcc cggactcgcg agccgggcaa ccgcagcgtg gtcacgctcg
     5101 gcctcaccgc ggcgggcggc gagctggtac accgcgtgct gacgtcccgg cgcgaaaccc
     5161 tctcccgcct gctggggcag ctcgatccac gagatgtcga cggggccgcc aaggccttgt
     5221 ggcgtctgac gaaactcgcg gccgcggacg aagcacttgg cgacctggtg ccctatccgc
     5281 acggctgatc cccgccgccc acttgttgca cgacgcaacc aacagtaagg tcaccgcggt
     5341 gctggtggtc accttcgggc ggctgggcga catgatcggc cgagtccgca tgtacaacgc
     5401 cggtttcgcc gtgttcacgg tgttctccgt gctgctgtcg gtgacgtgga tgcaaggcac
     5461 ggccggcgcg ctgtggctga tcggaatgcg cgtgctgcaa ggggtcggcg gcgcgatgct
     5521 gatggcgaac tccagcgcta tcctcaccga cgtcttcccc gtccagcaac gcggattggc
     5581 gttgggcctg aaccaggtgg cgggcctcgc ggggtcgttc atcggcctga tcctcggcgg
     5641 gctgctggca ccggtgcagt ggcacctggt cttcctggcg tcggtcccgg tcggattgtt
     5701 cggcacctgc tgggcgtact ggaagctgcg cgacaccggc accaccgagc attcgcggcc
     5761 ggactggtgg ccgcgctgct cgggtacaac ccgatccagt ccctgctcgg cccgagcgcg
     5821 ctccagcagc tgcccgccga ccacgccgcg tacctcaccg gccggagctt cttccccgcg
     5881 ctgatctccc cgccgttctc ccaggggctg gccatcgcct tcggtttcgc ggtggcctcc
     5941 tgcctggtgg ccgccatcgc atcctggctg cgcggcggca agtacgtcta cgccgaacca
     6001 ccggaacccg tcccgccccg gaccgtcccc ccagcacgcc aggaggaagc cgcggtgccg
     6061 ggccccgcgc cgatcgggct ccagcaaccg gatccgcccc gagccgcgag cgaatgatgt
     6121 tgcgggagcg ggcaatccgg cccgtgcgcc agcgtgcaca ccggcttcgg cgacttacgc
     6181 aagcgcggca gcggagttac ccttcacctg cggtaggaca cacgcggcgg gaggtgtcgg
     6241 gtggtccaga cggggttggc cgtgcgggtt gcgccgggcg caaccggtgt cggcggcctc
     6301 cctgcgatac ccggcccgct cgctccgcgg ttgccgttgg ggagttctcg gctgatccga
     6361 ccgcgagcag tcagccggcg gctggccgga aaccgattct gcgctgaagc tcgtcggcgc
     6421 gctcaacgcc ggaagccgga tcggggacgg cgcggcgacc gggagcggga tgattctcgt
     6481 tcctcacaaa ccgtttccgg gcggtagtcc cgatcgaccg ccacccggaa ccaatcgctt
     6541 gggaatcaag cacgaacccg tcgtccaccg gcgggcgcac cgcacggtgg agcattcggg
     6601 attaggagat gaggccgatg gcaaccgcgg aagatctgtc ggcgctcgtg agcaagctcg
     6661 gattggacaa gcagaacaag gcgacgctcg gccggttgat agcccacggc aacctcggtt
     6721 acgccgagga gggcgcggac ggccggatgc acgcccagat ccggattccg ccggacgagc
     6781 tggtctggga tcccgcgatc ctcgtcctgc cgcacggggg cgacctggaa ctcgagatct
     6841 tcaacgacga ccagaacacg cactgcgcgc tctttccgag caacggtgac agccagttca
     6901 tctggctgcc gatccactcc cggggaaccg ccgcactgaa cctcgacggc ccgggctact
     6961 actggtacag ctcgcccatc ggcaacgacg agggccgcgg cctgatcggg gcgatcgtcg
     7021 tgctcggcga cgccccgcag caggcccgcc tcgaccgccc ggaccagcca cgaccatagg
     7081 aaggagcggg tgatgacgga atacgtggat gcagggcggg ccgtcggcca ggcatcgctg
     7141 agcggcctgg ctggcattgc gccgccggtg gtccaggacg tcacgtacga acgcattctg
     7201 caggcccgct cggaaccgca gaactggctc acctactacg gcgcctacga cgggcagcgg
     7261 tacagcccgc tggaccagat caacactgag aacgtcaagc acctcgctcc cgcatgggtg
     7321 ttccagtccg ggtcggccgg tctccacgcg ggcccatcga cctactcgtt cgaggccgcc
     7381 ccgatcgtcg tggacggcat catgttcgtc tccgggtggg acggcttcgt gtgggccatc
     7441 gacggccgga ccgggcaggt gatgtggcgg tacaagcacg ccatccccta cgacacgtcg
     7501 ctgtgctgcg gcaacgtgaa ccgcggggtc gcggtggcga aggggaaggt cttcgtcgtc
     7561 acgctcaacg cccacgtgat cgcgctcgac gccaccaacg gcgagctcgt ctgggacgtg
     7621 acgtacggcg acgtgcgggc gggcgagagc gccacggtcg cgccgctggt cgtcaaggac
     7681 atggtcgtcg tcgggagctc cggcggggaa ttcggcgtgc gcggccacct cgacgccttc
     7741 gagctggaca ccgggcggca catctggcgg tgctacaccg tgccgaagcc cggcgagcga
     7801 ggctccgaaa cctggccgga tggtccggcc tggacacggg gcggcggcaa ctgctgggtc
     7861 acgggcacct tcgacccgga gctgaacctc atgtactggg gaaccggcaa cccggcaccc
     7921 gacttcgacg ggggcctccg cgagggcgac aacctgtaca ccgacagcgt catcgccgtg
     7981 gacccggaca acggcgagat ccgctggcac taccagtaca acccgcacga cctgtgggac
     8041 tacgacagca cgatggagca catcctcttc gagctggacg gacgcaagct gctggcgcac
     8101 ttcgacaaga acgggtactt cttcgtcctc gaccgcacga acggcgaact ggtccgggtg
     8161 tcgcccttcg tcgaccgcat cacgtggggc gagatcgacc cgaacggcaa ggtgacgccc
     8221 aagatctatc ccgagaagga aggggaagag gtccatttct ggccggggcc cgccggcggg
     8281 aaggaatgga cacacgcggc gtacagcccg cggacgcagc tgtgctacgt cccggtccag
     8341 gacgtcggcg cgtcggtcac gcgtcgccgc cgggagttca aggagagcat cccctactgg
     8401 ggtgcgagcg tcaccgtgga ctccgacgac atggcggggt cggtgtcggc cttcgatccg
     8461 tccaacggca acgaggtgtg gcgctggcgc aacgacgtgc cgatgtgcgg ttcggtgctg
     8521 gccaccggcg gggacctggt gttcgcgggt gaacctaccg gggagttcaa cgcgttcgac
     8581 gcgcgcaccg gcgagctgct gtggcagttc cagacgggct gcggccacca cagcagcccc
     8641 acggcctaca gcatcgacgg caggcagtac ctggccgtgc ccgtcgggtg gggtgcatgg
     8701 gtcgaaggat tccttcccgg gatgctcggg gctccccacg gggacgccct cttcgccttc
     8761 gcgcttccgc aggaatagtc ccggatgcgg gccggacatc cgcagggagg aggtgcagtc
     8821 atggaatccg ttgcaactcg gccaactctt gaatgggagt cgcccgagtt cgccgaagtc
     8881 gactgggagc caccggagtt cgaggagctc cagtgcacat ccgaagtgac gatgtacatg
     8941 tacgtcgcgc gatgggagga ctagcggccg gaggaccagc ggctgaggca cgggcgccgg
     9001 ggtcgagtcc ggcgcccggg tcgtgattct tttgggctgt gatagcaacc caaaagaatc
     9061 acgaccccgc tcggcactgg tgccgaatgc acgggcggag gagcggaatg tgggtgcggg
     9121 tgctcggatc ggcagcgggc ggcggctttc cgcagtggaa ctgcgcctgc ccgaactgcc
     9181 gcgccgtccg cgacggttcc cggccctgcc ggccgcgtac ccagtcggcg atcgcggtga
     9241 gcggcgacta ccggaagtgg ttcctgttca acgcatctcc cgatgtccgg acccagatcg
     9301 aggccttcgc cgccctgcag ccgagcggcg agcgggcgac accactgcgc gcggtgctgc
     9361 tcaccgatgc cgagatcgac cacacgctcg gcatgttgct gttgcgggag gcgaaagcca
     9421 tcgagctgca cgccacgccc gcggtgcagg agacgttgtg cgatgggaca gcagtgctgc
     9481 gaacgcttga agcctactgc caggtcacct ggcgaccggt cgttccgggc gccgacgtgc
     9541 gcctggatgg cgggctttcc taccgggcct tcgacgtccc caccagcaaa ccgccccgct
     9601 tcggggcagg ccgcgagcag ggacgggtcg tgggctaccg gctgaccgac gagtccagcg
     9661 gccgggcggt cgtgtacctg ccgggggtgc aggagctcac cgccgaagtg ctcgcggagc
     9721 tggatgactg cggctgcctg ctcgtcgacg ggacctgctg gcacgacgac gagctgatcc
     9781 ggctcggcct ggcccggaag acggcgcgcg acatgggaca cctgccgatc ggggaccctg
     9841 ggggcagcct cgaacagctg tcaccgctgc ccatcgagcg caagatctac atccacatca
     9901 acaacaccaa cccgatcctg ctggacgacg cacccgagcg gcgtgccctc gagcagcgcg
     9961 gcatggaagt ggccgcggac ggattggagg tgcgagtggc gtgacgacgc ttaccgacac
    10021 cggcagcttc accgcgcagc tgcgcgccca gtcgcggcgc taccacgacc agcacccgtt
    10081 ccacgtcaag atgaacgagg ggcggctgag ccgtcggcag atccggggat gggtggccaa
    10141 ccgcttctac taccaggcga acatcccccg caaggatgcc gccatcctcg ccaactgccc
    10201 ggatcgcgga gtgcgccggc gatgggtcct gcgagtcctc gaccacgacg gcacggctgg
    10261 cgacgaaggc ggcatcggcg cctggctgcg cctggccgag gcggtggggc tggcccggga
    10321 ggaggtgctc gacgagcgcc atctcgtccc cggggtacgg ttcgccgtcg acgcgtacgt
    10381 gaacttcgcc cgcacgcggc cgtgggtcga ggcggtggcg tcctcgctga ccgagctctt
    10441 cgcgccggac ctgatggccg accggctcgc cgcgttcgaa cgccgctacc cctggatcga
    10501 ccgcgacggc ctcggctact tccggtcccg cctcgcccaa gcgccccgcg acgccgaaca
    10561 cgccctgcag gtggtgaccg agcactgccg ctcggccgac gagcaggcgc gcgccgtggc
    10621 ggcgctgtca ttcaagtgcg aagtgctctg gagcatcctc gatgccatcg accaagcttt
    10681 tcccgactcc ggcgatgcgg gaacgctatg agcacggcag tggaatcggc gagccgcccc
    10741 aggatggcgt cgtacgtgcg cctggtcttc gaccaggtgc gcgagcggca catgctgttg
    10801 gcaccggagt cggtgtcggt actgaacccg accggcgcgg ccgtactggg cctgtgcgac
    10861 gggcggcgga cggtcgccga gatcgtggcc gagctgcgtg gccagtccga ccacctggca
    10921 tgcgacgagg tgctgggctt cctcagccgc ctcgccgcca agcggtacgt ggaggtcgac
    10981 gatgactagc cccttcggtt tgctggccga gctcacgtat gcatgcccgc tgcactgccc
    11041 gtactgctcc aacccgctca acctggccga ctacggggaa gaactgacca cggcgcagtg
    11101 gcagcaggtg ctgaccgagg cccgcgagct gggtgtcgtg cagctccaca tgtcgggcgg
    11161 cgagccgctg cagcgccggg acgtggtgga gatcgcacgc agcgccaacg agttgggcct
    11221 gtacacgaac ctcatcacga gcgcgatcgg cctctcaccg cgccgcgcgg aacagctgcg
    11281 agcggccggt ctcgaccacg tgcagatcag catccagtcc cacgaggcga ccgtgtccga
    11341 cagcatcgcg ggcacgccct ccttcgagcg caaggtcgcg gcggcacggc tggtgaagga
    11401 gctgggctgg ccgctgacgt tgaacatcgt cctgcaccgg atgaacatcg accgcatctc
    11461 cgacatcatc gccctggccg agcgactgca cgccgaccgc atcgagttgg cgaacaccca
    11521 gtactacggc tgggccttgc acaaccgctc cgcgctcctg cccagcagga aacagatcga
    11581 tcgggcggcg gccgtcgtac gcgccgcgaa caagcgcctg gaggggaaga cgacgatcat
    11641 ctacatcctg cccgactact actcccagta ccccaagccc tgcatggacg gttggggacg
    11701 gcgacagctc accgtgacgc ccaacggcga cgtcctgccc tgccccgccg cgcacaccct
    11761 gccgctgccg cgcgcgagcg tgcgcgagaa gtcgctcgcc tggatctggg cggaatcgcc
    11821 ggtgttccag cgcttccgcg gcaccgactg gatgcccgag ccgtgccgga gctgcccgcg
    11881 ccgcgagatc gacttcggcg gctgccgctg ccaagcgttc ctgctcaccg gggacgcggc
    11941 ccgcaccgac ccggtctgca tcctctcgcc ggaccacgag atcgtggccg acgcggtgcg
    12001 cgccgccaac gaggagacga ggcccctcgc ggaggccctg acaccacgcc cgcacccgcg
    12061 agacacccgg tagagaggtg gtacaggtaa accaggtact cgccggaggc tgacggcccg
    12121 tgagtgtttt tgggtgccat agcacccaaa aacactcacg ggccctgacg cggcgagagc
    12181 atcgacgatc tcgaagcgac cctcaaggcc aacggcgcgt ccatcaccac gccgaacacc
    12241 gctggcccca ccgggcgcct gcaacttgag ttgcgcctgt ttcatcctgg cctatccgca
    12301 acgcgataac gcgcatttgc gcgaatacct ctcaatgcga ggtaacgttg tcgtgtgggc
    12361 gatgtggacg cgcgggtcgt cgccgacgag ctgatgaccg tgatcgcggc gctgcggcgg
    12421 acagtgcgcc gtagtcttcg cgccgagctg ccgacgccag acctgcgggg tgcccaggtc
    12481 gaactgctgc gggtcgtcga acagcagcag ggcatcagcg tgaccgccgc cgccctgcaa
    12541 ctgcggatgg cggcgaactc cgtcagcacg ttggtcaacc agcttgcccg cgtcggcctg
    12601 ctgcgccgcg acaccgatcc cgacgaccgc cgcgcgatcc ggctgcacct gaccgacacc
    12661 gccgcgcacc ggctcgcggc ctggcggcag gcgagaaccg gcctcgtcgg cgatgcgctc
    12721 gccgaactgt ccacagcaga ccagaaggcc gttgccggtg cgctgcgcgg tttgcacgcg
    12781 ctggtcgagg ccctggaagg aggtggcgcc gatgaccgag cggatggccg tgcgatgcaa
    12841 gggtctgcgg cacgcgttcg gcgaccagat cgcggtcgac ggggttgatc tggacgtgcg
    12901 gcccggcgag gtgttcgggt tgctgggacc caacggcgcg ggcaagacca ccacgatccg
    12961 ggcgatcacc acgctcctgc ccaccagggc gggaacggtc gaggtcttcg gcgtcgatgt
    13021 ggcgcgccac aagctggcgg cgcgacgact gatcggctat gtgccgcagc agctttcggc
    13081 cgacgggtcg ctgaccgggc gggagaacgt cgcgctgttc gcccggctct tcgacgtccc
    13141 ccgagcgcaa cggcgatcgg tggtgcgtgc cgcgctgggc gcggtcgggc tcgccgatgc
    13201 cgccgagcga ctggccaaca cctactcggg cggcatggtg cgccgcctgg aactcgccca
    13261 ggcgctcgtc agcgggccga agctgctggt gctggacgag ccgacgatcg gcctcgaccc
    13321 catcgggcgg gagagcgtgt gggaccggat ccgcgagatc cgcgccgaga ccggcatgac
    13381 cgtgctggtg acgacgcact acatggacga ggcggaccag cactgcgagc ggatcgccct
    13441 catgcaccgc gggcggattc gcgcgcgcgg cactccggcg gagctcaagg ccgccgtggg
    13501 gccggacgcc acgctcgacg acgtcttccg gacgatcagc accgacgcct tcggcgccgg
    13561 aacgggggaa gggatgcgag atgtccgcgc ggctcgacgt acttccagcc gcctcggttg
    13621 aaccggtgcg gcgcagcctg ccgggcctgc tgttggcgcg ggtggcggcg atgtgcctgg
    13681 tagagctgca gaagttgcgg cacgaccgga ccgagctgct caccagggcc atccagcccg
    13741 cgctgtggct gctgatcttc ggcgaggtgt tcaccaggct gcgggcgatc cccaccggga
    13801 acatcccgta cctggactac ctggcgccgg ggatcctcgc gcagtcggcg ctgttcatcg
    13861 cgatcttcta cggcatccag atcatctggg aacgggatgc cggcgtgctg gcgaagctgc
    13921 tggtcacgcc cacgccgcgg gtcgccctgg tcaccggcaa ggcgttcgcc gccggggtgc
    13981 gcgcgctggt gcaggcgctg gtggtgctga tgctggccgc gctgctcggc gtcggcctca
    14041 ccgccaaccc ggtgaacctg ctcgcgatgg ccgtggtggt ggtcctcggc tcggcgttct
    14101 tctgctgcct gtccatcacc atcgcgggac tggtgctgtc cagggatcgg ctgatgggaa
    14161 tcgggcaggc gatcacgatg ccgctgttct tcgcctccaa tgcgctgtac ccggtcgatc
    14221 tgatgccgga atggctaaag gtggccaact atgcgaaccc gctcggctac gaggtggacg
    14281 cgttgcgcgg cctcctgatc ggcacgcccg cccacctggc gctggacttc gccgtcctgg
    14341 tcgtcgccgc cggcaccatg atcagcatcg cctcggcact cctcggccgc ctggcccggt
    14401 gaacggcccc ggggacaaga cttccgccga tttcgcgcga aatcgccgca cctgacgcgt
    14461 gcacgatggc gatttcgcgc gaaatcgcca cacccgacgc gtgcacgatg gcgatttcgc
    14521 gcgaaatcgc cgcacccaac gacgtccagg tgccggccac gaccatccgg aatagaccac
    14581 caaccttggg ctgcccgaat tccgcgtggg aggttgcgcc gcgacgacta gcaccaaccc
    14641 ggcccacgac tgttgcaaag cagttgcaac tagactctgg cggtagcgcc gacatgagaa
    14701 gggaaggtcc cggtgagcaa caaccgtcga gcagcactcg atgcggtccg agccaactgg
    14761 aatcgacggg cggcggggta cgaccgcttc taccgggact acacgcagga caaacgcgat
    14821 gcgtggcgcg cggcctacga gaagatcctc ggcgagctgt tcgcgcggcg cgacgagcca
    14881 ctgaaggtcc tcgacgtcgg caccgggacc gggttcctct cgacgctgct ggccgaactc
    14941 gggcaccacg tgaccgcgat cgacccgtcc ggcgcgatgc tcgactacgc ccgcgccgaa
    15001 gcagaccgcc ggggcgtcga ggtgcggacc attgcctgcg gcgctcacga cgtcgcgagg
    15061 ctggacaccg agttcgacct cgtgaccgcg cgatacgtcc tgtggacgct gcccgatccg
    15121 gtcgccgcgc tgcggacctg gcgcgaggtc atcacccccg gcggcggcct gctgctcgcg
    15181 gacgggctct ggcacacctg gcggcacgac ggccgccggc tcgccgcatc gctgcggccg
    15241 ggcggcgacc accagttcct ctggcaactc ctgcacgact acgcgcagat cggcaacgcg
    15301 acgccgcact gggcgggcct gaccctggat cgcacgcggg cgctgttcgc cgcaggcgga
    15361 ttccagagcg gtactcgcca cgaccagctc ctacccgaat acgcccaccc cgtcagcgcg
    15421 gacttcttca tcctgggaac gcgacctgca cgacttccat gacaccaatc acttccgtgc
    15481 cagaagcgag aaaagcgatc gtccattgtg gacaacgaga tccacaagac ccgggaagca
    15541 aggatgccga cctgccgctc agcgacattc gccccgggac tcccctgagc gccgccagcc
    15601 agggtgcgca gatctcattc gcggcacgcc cgttggcgcg gccgagttcg gccgggatgc
    15661 tgcggggcgg cgtgaccagc ccttgtcggc cagcgcggct tcggccacgg cgacgtcact
    15721 gaaggggtgc tggatcccct cgacggtttg gtaccgctcg tggcctcgcc cggcgatgag
    15781 caccacgtca ccgggctcgg cgcgctcgat cgcagcggtg atcgccttcc accggtcgcg
    15841 ctccaccacg atcgccgccc cggcacggcc gatcgtcccg gtgagcatct gggcgatgat
    15901 ctcctcgggc acctcgtcgt ggggatcatc ggcggtgaag atcgcgctgt cggcggtcag
    15961 cgcgacgcgt cccatgtcgg ggcggttgaa ccggtcccgg tttcccgcgc tgcccaccac
    16021 caggtgcacc cggccccggc tcgcccggcg cgcggtggcg atcagctggg tcagggcgcg
    16081 cggcgtgtgc gcgaagtcga ccaccacctg gaacggctgg tcggcgtcca cccgctggta
    16141 gcggccgggt ggcggggccg cgcccagccc gaccactgcg tcccgccgcg acacccccat
    16201 cagccgggcg gccgcatagg cggcggccag gttcgcggcc tggcccacgg cgggcgtggc
    16261 cagctccacc cggtcgacgc cgtcctggac gacgacccgc agctcatcag aggtcgaggc
    16321 gacacgcacg tccgcctgcc cggctcgccc cacggtcacg gtcggcacct tcgcctgggc
    16381 agccagccgc ttcccccacg aatcgtcgat gttgatcacc gcccggcggc agcagtccgg
    16441 ggtgaacagg gccgctttgg tcgcgtagta ctgctcgacg gtgccgtggt aatcgaggtg
    16501 ctccgggctg aggttggtga acacggcgac gtcggccgtc acggcgtcgg tgcggtgctg
    16561 gtcaacggcg tgcgaggata cctccatccc cgccgcctgg actccttccg cacgcatgcg
    16621 gcacaacgtc cgctggagct ccgcggcgcc gggcgtggtc aatgccgccg ggctgcgcgc
    16681 cccgggcatc ctggcctcga ccgtggagac caggccggtg cggtagccgg cggcggcgag
    16741 cgcagcctcg atcaggtgca ccgtggtggt cttgccgtcc gttccggtca cggcggcgac
    16801 ggccagcgca tctgcgggat acccgtgcac cgcggcggcc accggtccca ccgccggccg
    16861 cacggcgggc acccgcactt ggggcaccgg cgcgtcgacg aaccgtttca ccagcagcgc
    16921 gctggccccc gccgccaccg catcgtccac gaatgcgtgc ccgtcccgct gcgttccggg
    16981 cacggcgcag aacagcgcgc cctggcgcac acacctgctg tcgtcggtga cgtccaggac
    17041 gtcggcgtcc ccgcgcagct cggccccggg gaggtcccgc gtggccttcg acaggctgat
    17101 tcctgcgtgc tgacaaccgc attccatgtc gcacccgtca acttcccgga cgtccaccgt
    17161 cgccccgaga cgtggcacca tccgtcaccc gaagcgccgc ttcggccgcg ctgactcgcg
    17221 tcaggtaagc agtgtcgacc cgctgccgcc ggtccgcgag tcgcccggat ggcagcgcgg
    17281 ttcccggctg atcggttgtg ggcactggag aaacgggagt ggcagctgag gttccgctcc
    17341 actttgacta cattaccccc ctagggtata aatgaggtgt cggccgccgg accgacgacg
    17401 agtcagcgga agggaggtcg acgtgatcga ggccagctac accgtgaccg gcatgacctg
    17461 cgaccactgc gcgcggtcgg tgaccgagga ggtcagcaag atcaacaagg tctcgggcgt
    17521 gtcggtgagc ctgcccaccg gtgccgtgac cgtgcgcagc tccgagccgg tgaacgacgc
    17581 cgacgtgcgc gcggccgtcg aggaagccgg ttacgaactg gccgccaggt aacgagcgcc
    17641 acccaacccg aggaccgccg tgttcgccgc cttcacaccc agcggagacc ggacctcggc
    17701 gcctccccac caacgatggg cgcacacgcc gggcctagca tcgccttcga cctcgagatg
    17761 ccatccggcg ccatggagac gcaccaggtc cgcgccgcgg aaatcgcagt cgacgcgcag
    17821 cagccggcgg acgggccgcg gggccccgcc gacgacggcc acgcaggaga accccgatga
    17881 gcactgggac gagccccacc gcagagatcg aactggccat cggcggcatg acgtgcgcgt
    17941 cgtgcgccag gcgcgtcgag cggcggctcg gcaagctcga aggcgtcacg gccacggtca
    18001 actacgccac cgagaaggcc aaggtcgcct tcccggaaac gctcgatctg cagcagctgg
    18061 tcgaacaggt cgaggcggcc ggctacacgg ccgaactgcc cctcgaaccg gcggccgaag
    18121 ccgaagaccc gacgaagtcc ttgcggaacc ggctgctcca ctcggccgtg ctgtcggctc
    18181 cggtgatcgc gttggcgatg atcccggcgc tgcagttcac caactggcag tggatctcgc
    18241 tcgttatcgc cacgccggtc gtggcgtggg gcgcgtggcc gttccaccgt gccgcctgga
    18301 cgaacctgcg ccacggcgcg gccaccatgg acaccctgat ctccttgggc acgctggcgg
    18361 cctacgcgtg gtcgctctac gcgctgctgt tcggcaccgc cggcaccccc ggcatgacgc
    18421 acgggttcga actcaccatc cagcgcatgg gcggcgacgg gaacatctac ctcgaagtag
    18481 cggccggggt cacgacgttc atcctcgccg ggcgctattt cgaggtgcgc tccaagcgcc
    18541 gggcgggtgc cgcgctgcgc gcgctgctgg agctcggcgc caaggacgtc gcggtgctac
    18601 gcgacggcgt cgaggtccgc atccccaccg atcgactcgc cgtcggcgac cggttcgtgg
    18661 tccgccccgg ggagaagatc gcgaccgacg ggatcatcga ggagggcagc tccgccgtcg
    18721 acgcgagcat gctcaccggc gaatccgtgc cggtcgaggt cgccgcaggt gacgccgtag
    18781 tcggcgccac cgtcaacgcg ggcgggcggc tggtcgtccg cgccacgcgg atcggcgcgg
    18841 acacccagct ggcccagatg gccaagctcg tcgaggacgc ccagaacggc aaggccgccg
    18901 tgcagcggct ggccgaccgg atctccgcgg tgttcgtccc catcgtgatc ctgctggcgc
    18961 tcgggacgct gatctcctgg ctcgccaccg gtgccggtgc cgccgccgcg ttcaccgccg
    19021 ccgtcgcggt gctgatcatc gcctgcccgt gcgcgctggg cctggccacg ccgaccgcgc
    19081 tgctggtcgg caccgggcgc ggcgcgcagc tgggcatcct gatcaagggt ccggaggtgc
    19141 tggagtcgac ccggcgcatc gacaccgtgg tgctggacaa gaccggcacc gtcaccagtg
    19201 gacagatgtc gctggtcgcc gtgcacgccg cggacgggat cgacgaggaa gcggtgctgc
    19261 gcctggcagg tgcggccgaa cacgcgtcgg aacacccgat cgccaaagcg atcgcgcgag
    19321 gggcagccga gcgagtgggc gagcttccgg ccgtcgagga gttcagcaac gtcgaaggac
    19381 tcggcgtgca ggccgtcatc gacggccgcg ccgtgctcgt cggacgcccg gcgctgctcg
    19441 cgcagtggag ccggccgctt cccgccgaac tggtcgcggc gcagaccaag gttgagaagc
    19501 agggccggac cgccgtcgcg gtggcatggg acggtgccgc ccgcgccgta ttggcggtcg
    19561 ccgacaccgt caagccgaca tccgcagcgg ccatcgccgg actgcgcaag ctcggcttga
    19621 agccggtcct gctcaccggc gacaacgaca cggtggcgcg cgcggtggcg gccgagaccg
    19681 gtatcgacga ggtcatcgcc gaggtcctgc cgcaggacaa ggtcgacgcc gtcaagcggc
    19741 tgcagtccga aggtcgcgtg gtggcgatgg tcggtgatgg cgtcaacgac gccgccgccc
    19801 tggcccaggc cgacctcggc ctggccatgg gcaccggcac cgacgtggcc atcgaggccg
    19861 gcgacctgac cctggtccgc ggcgacctgc gcgcggcggt ggacgcgatc cggctgtccc
    19921 gccggacact cggcaccatc aagggcaacc tgttctgggc cttcgcctac aacgtggcgg
    19981 ccctgccgct tgcggcggct gggctgctca acccgatgat cgccggtgcc gcgatggcgt
    20041 tcagctcggt gttcgtggtc ggcaacagcc tacggctgcg ccgcttccgc agcaccagca
    20101 cgaccggacc gatgcccgga accgaagcga gcgagccggt tccggctgcg gcacgtcgag
    20161 actgatcccc tgtgcccggt ctcgcgacgt ctatccgcag ccgaaaggac taccgatttg
    20221 aacactcgtc cgtctacaac ggacgcacca gcgaggaccg gtgcacgcga gcctggaagc
    20281 cgcgctgcac cgctgctgcc accagctcat ccccgcgatc agggccggaa tccggaatcg
    20341 ggggaagttc ggcgaatcgg ccgtggaact cacgtcaacc gccctggccg cttgccaacg
    20401 caaaccgcgg aaatgacgtg aacgcagcgg cccggctaat taggtgcgcg aacagccaca
    20461 tcgcccatgg ctgcggcaaa accctagtcg gcggaccttc gcgagctcga agccgtctcg
    20521 tgttcgcctg cgtccgccgc cggctcgagc cccgctccgt tggacgtcgc ttgctggagt
    20581 tcctgcagcg cggcggcggg gtcgcggaac agtgccgggt tgcgctccca gtgcgccagt
    20641 tccaactggg tcaggttgcg caccacgacc acctcgtcca ccttgaccag gagcaccgat
    20701 ccgatctgca cgatggcgcg cggggtgttc gacagcgact ggatcagccc cgccaccgcg
    20761 gctccctgcg cggcatcgac ctcggcctgc tggcggtcca gcaggcgcag gtccagggcc
    20821 cggctgagct tgacgaactg ctcctccttc gtcggcagct gccccgaatt cttcaaccgg
    20881 atcaggaact cgccgaacca cgacccgacc acgggcggga aggcgtgggc gaactccagg
    20941 ccgaaggcct cgaccactcg ttccgccgcg tccgccacgg cctggtgatc ccgctcgtcg
    21001 ctgaggtaga tccgaccggg aacccagtgc cagccgatgg tttcggcatc cgggtccggc
    21061 tgcgcggcca acgccgcgcg gtccacgagc agggcccggg ccgaggccac gtcgggcacg
    21121 atccggaaga ccctggtcag tcccgtgatc cggaagatct tgagcaaccg ctcggtactg
    21181 cacaccacga tcaattcacc gccgcgagcg cgcgcccgct tcaacccgcc gaccagcacg
    21241 ccgagcccgg tgctgtccag gaagtccagc ccgttcaggt ccacaaccag ccggacctcg
    21301 tcgccgccca gcgcatcgac gaaccgctcc cgcaggctgg gcgcggtgta gacgtcgagc
    21361 tcaccggcca cctcgaccag gatgatcccc tcggacagcc tgacgttggt catcccgagt
    21421 tccacagcgc ctccctgagc agtcttctcg agtatgccaa cagaaccggc gtggcaggaa
    21481 cgctatggca acacggtcga cggtcttcgc aagccgtttg gccgacaagt cgcgcgacgg
    21541 cacccgttgc cgcggcctgc tcgggctgcg gcgcgtgctc gccgaggatg gcggcgcggc
    21601 gccggtcggc gtgaccttcc ccgagctcac ccgcatccgg aggacgtggt agctgccttg
    21661 gcggagcacg acgtgaccgt cgacctgtcg tgaatccggc tccgtcggct accgggcccg
    21721 cgactatcct cttagaccgc tgccggagtt ccccggaggt attggagaca cgccgaggct
    21781 tcagggggcg atggcgtgtt cggtgaaccg cccgcaggag cggaatccca agcggcggta
    21841 gacgggttcg ccgtccgcgg atgcctgcag gaccgcgacg cggtggtcac ggctgcgcgc
    21901 cgcgtggagc gcggcgaggg tgatggcacc gccgtagccg cgtcggcggt gggcggccag
    21961 cgtgcagatg ttgtagatcc cggcgactcc cgcgtggcag aagacctcgg ccgagcaggc
    22021 cggacggtcc gccacgtagc cgaccaggta gcgcgccggg caatcggtgg cca
//
