LOCUS       NZ_CP050976            23754 bp    DNA     linear   CON 06-JUN-2024
DEFINITION  Streptomyces sp. RPA4-5 chromosome.
ACCESSION   NZ_CP050976
VERSION     NZ_CP050976.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RPA4-5
  ORGANISM  Streptomyces sp. RPA4-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9051652)
  AUTHORS   Nicault,M., Bontemps,C., Tidjani,R., Gelhaye,E. and Leblond,P.
  TITLE     Mining the biosynthetic potential for specialized metabolism of a
            Streptomyces soil community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9051652)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72x/76x
            Sequencing Technology :: Oxford Nanopore GridION/Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012273495.1-RS_2024_06_06
            Annotation Date                   :: 06/06/2024 02:35:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,979
            CDSs (total)                      :: 7,887
            Genes (coding)                    :: 7,432
            CDSs (with protein)               :: 7,432
            Genes (RNA)                       :: 92
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 455
            CDSs (without protein)            :: 455
            Pseudo Genes (ambiguous residues) :: 0 of 455
            Pseudo Genes (frameshifted)       :: 276 of 455
            Pseudo Genes (incomplete)         :: 232 of 455
            Pseudo Genes (internal stop)      :: 23 of 455
            Pseudo Genes (multiple problems)  :: 71 of 455
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:36:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8774634
            Orig. end                         :: >8798388
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050976.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..>23754
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="38"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..>23754
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..>23754
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:>13754](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..>13754
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    33..46
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     misc_feature    complement(234..248)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 17.94"
                     /tool="antismash"
     gene            complement(825..1988)
                     /locus_tag="HEP86_RS38540"
                     /old_locus_tag="HEP86_38540"
     CDS             complement(825..1988)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145924.1"
                     /locus_tag="HEP86_RS38540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38540"
                     /product="acyltransferase"
                     /protein_id="WP_168483130.1"
                     /transl_table=11
                     /translation="MRELIRRIDAATPADRDRGVDALRALAILGVMLGHWLVTALVADS
                     GTVRVVSPLHELPHLTPVSWLLQTLAVFFLVGGQMAATSYAATRARGGTYRGWLGARMA
                     RLFRPVAAMLVVWSVVAGGLLVAGAGLDTVHTLGKLALSPLWFLLVFAALTAATPVAAR
                     LHPLWPLAVVLHIDLLRFGLGGPAWLGWTNVAAGWLVPYCLGAAWARGGLRSRATAWVL
                     LLGGAATTAGLVLWAGYPAAMVGVPGAVISNLNPPTLAAVTFGLAQCGAALLLLGPLQR
                     LLQRPAVWAAVALMNLSAMTLFLWHQTAMMAVTAVGLLTGGFLPGLHTLPDGAGWVLAR
                     LGWLPVFALALLVCWSAFRTYEQGRRRGSSMVVRAGRPAEVGAVRRA"
     gene            complement(1981..2949)
                     /locus_tag="HEP86_RS38545"
                     /old_locus_tag="HEP86_38545"
     CDS             complement(1981..2949)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091926.1"
                     /locus_tag="HEP86_RS38545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38545"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_168483131.1"
                     /transl_table=11
                     /translation="MASRPRGSRPLRTLLAAFVVTAVVVPVSGAARPAAVPAPAPKALA
                     PLRSAAPGALAERYAVNREGIRAAERMAEGHGDRARAGVLRGMAGPERQFLFFDGRDGG
                     RTTEVFGDLARADRITVLVPGSDTHLDRYARLRSGALALQRELGGRSAVLAWVGYRTPS
                     TVSPDVLTPGRAAEAAPGLRAFVGAVAKLRPTARLSVLCHSYGAVVCGRAAPGLDVADL
                     VLFGSPGAGAENVAALHTPATVWAGRGDDDWIADVPHGQLQLPFGTLGLGADPVAPEFG
                     ARVFAAGPGGHSDYLTPGSVSLRNLARIVSGQAPSEESSDA"
     gene            3237..4652
                     /locus_tag="HEP86_RS38550"
                     /old_locus_tag="HEP86_38550"
     CDS             3237..4652
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823913.1"
                     /locus_tag="HEP86_RS38550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38550"
                     /product="MFS transporter"
                     /protein_id="WP_168483132.1"
                     /transl_table=11
                     /translation="MVRADRPRADRPGRPAAPGRPPAPLLAVCAGYFMVILDVTVINVA
                     VPVVGRELSASLTGIQWITDGYTLVFAGLLLTGGALGDRLGNRRIFCTGVVVFTLASAA
                     CGLAPTSGALIAARLVEGLGAALIVPGSLALLQQAYPAPAERSRAFGLWGSMAGIAASA
                     GPLLGGLLVTTVGWRWVFFINLPVGCACLLLTLRHVSASARRTDRPLDWPAQCALIATV
                     ALLTTVLNEAGRRGWTDPLILTGAGLCLLSAAAFVLRERLARTPVLPLRLLRSRPMSGA
                     AAIGLLFNFAFYGMIFTASLYFQHHRGLTALRTGLALFPAVAMTMFASVLSGRLARRTG
                     HRPLVVTGMLLGAAGLAGWAAAGPDPDYLLLVGPMMAAGFGTSFALTGATATVMSAAPD
                     AYSGTASALFNTTRQIGSAAGVALGGSLLAAAAGFPAGLRTSMAIGAAAYLMAAVLAVL
                     CVPPKGHKSRAAG"
     misc_feature    3244..3258
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     gene            4800..5429
                     /locus_tag="HEP86_RS38555"
                     /old_locus_tag="HEP86_38555"
     CDS             4800..5429
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091443.1"
                     /locus_tag="HEP86_RS38555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38555"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_168483133.1"
                     /transl_table=11
                     /translation="MSTLIVTAFVTLDGVMQAPGGPDEDVDSGFTHGGWQVPYVDDDFM
                     GLMTGVFEHTADHLLLGRKTYDIFATYWPRVTDPDNPIAVKLNSMPKYVASRTRNSLEW
                     NNSQLLEGDAAEAVARLKQELDGVLMTQGSSDLIRTLQQHDLVDEYRLLINPVILGTGK
                     RLFADGAAPTAWRLTESRTTGAGVQYCVYQRAGKPEYGTFELDEQD"
     misc_feature    complement(5499..5515)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.12"
                     /tool="antismash"
     gene            5713..6498
                     /locus_tag="HEP86_RS38560"
                     /old_locus_tag="HEP86_38560"
     CDS             5713..6498
                     /NRPS_PKS="Domain: Thioesterase (22-246). E-value: 3.1e-39.
                     Score: 127.7. Matches aSDomain:
                     nrpspksdomains_HEP86_RS38560_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091578.1"
                     /locus_tag="HEP86_RS38560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38560"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_085926049.1"
                     /sec_met_domain="Thioesterase (E-value: 3.6e-38, bitscore:
                     130.8, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-08, bitscore:
                     34.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVAASAVPERVVLAARPQAALRLYCVPPAGAGPDCYLRWAPLLP
                     PWIEPCSVALPGRGTRAAEPSLTDPAYLSARLAAVLDDWTDPRPFAVFGHSAGALLAYE
                     ATRHLRRTHGRLPSLLAVSSLSAPHIDAYSAGLPPRLTAGLEGIRELVGPIPDQLLADA
                     RLMAAACTPLLADCLLLLHYRHRPEPPLDVPLALYGGEHDPVTSVPDLQAWNDLVTTPA
                     PVQLFPGGHTYLQTETKALVDRLTETLDPARYARPVATA"
     aSDomain        5779..6450
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS38560_Thioesterase.1"
                     /evalue="3.10E-39"
                     /label="HEP86_RS38560_Thioesterase.1"
                     /locus_tag="HEP86_RS38560"
                     /protein_end="246"
                     /protein_start="22"
                     /score="127.7"
                     /tool="antismash"
                     /translation="RLYCVPPAGAGPDCYLRWAPLLPPWIEPCSVALPGRGTRAAEPSL
                     TDPAYLSARLAAVLDDWTDPRPFAVFGHSAGALLAYEATRHLRRTHGRLPSLLAVSSLS
                     APHIDAYSAGLPPRLTAGLEGIRELVGPIPDQLLADARLMAAACTPLLADCLLLLHYRH
                     RPEPPLDVPLALYGGEHDPVTSVPDLQAWNDLVTTPAPVQLFPGGHTYLQTETKALVDR
                     LT"
     CDS_motif       5977..6039
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEP86_RS38560_0001"
                     /evalue="4.00E-06"
                     /label="NRPS-te1"
                     /locus_tag="HEP86_RS38560"
                     /protein_end="109"
                     /protein_start="88"
                     /score="19.4"
                     /tool="antismash"
                     /translation="PFAVFGHSAGALLAYEATRHL"
     gene            6495..8105
                     /locus_tag="HEP86_RS38565"
                     /old_locus_tag="HEP86_38565"
     CDS             6495..8105
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091577.1"
                     /locus_tag="HEP86_RS38565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38565"
                     /product="MFS transporter"
                     /protein_id="WP_248001524.1"
                     /transl_table=11
                     /translation="MTAAVPARTPAPPVRRAAAAAVVCLGLFMLGLDLTVLNVAVPDLQ
                     GGLETSTAQVQWIVDGFALVLGGTVLAVGAFTDAWGRRRSFVCGVAVCGGASLGGALAA
                     QPWQVIAARCTMGAGAALLMPATLAVLHHLFPEPRLRSRAIAAWAAVGGMGGLCGPVIG
                     GGLVEHFSWRAAFWINLPLAAVIIVLALLLVPESHTRRRAGFDVPGAALSAAGLLVLVW
                     SITESPHRGWTSPAALTGFAAAALLLAAFVRRQLHAPAPMLPLSLLRVPAIGVAAAALA
                     LMSFAMFGALFVLTLYLQGVLGFSPWQAGLRTLPLPAGLALGAVCAVPVRARLGGRVPV
                     VGGLALVTVGFAILATTTPDSDYPHCAAFQLVAGFGAGLVAAAATESVMGSVATERAGL
                     GSAINDATRQVGSALGVAVQGSLLAAVFTSRLTASLTDLHAPAPVAAAARHSMLSVPAQ
                     AMRLPGPLRSSVLSAARRAFTDAMTLTAVVAGAVTLLTAAAAARWLGRPDRQDGAPRPA
                     GARLHGPQPAPREEERPAL"
     gene            8387..8650
                     /locus_tag="HEP86_RS38570"
                     /old_locus_tag="HEP86_38570"
     CDS             8387..8650
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (7-69). E-value: 4.7e-11.
                     Score: 34.8. Matches aSDomain:
                     nrpspksdomains_HEP86_RS38570_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091576.1"
                     /locus_tag="HEP86_RS38570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38570"
                     /product="acyl carrier protein"
                     /protein_id="WP_168483134.1"
                     /sec_met_domain="PP-binding (E-value: 3.6e-08, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTSAELITSTLTETFDLDPAEVMPECTFEDLGLDSLALVEMGLM
                     LQERTGISLDDVPLRTTLGELAALMDSGTAGQALTTAPNSGS"
     aSDomain        8408..8593
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS38570_PP-binding.1"
                     /evalue="4.70E-11"
                     /label="HEP86_RS38570_PP-binding.1"
                     /locus_tag="HEP86_RS38570"
                     /protein_end="69"
                     /protein_start="7"
                     /score="34.8"
                     /tool="antismash"
                     /translation="ITSTLTETFDLDPAEVMPECTFEDLGLDSLALVEMGLMLQERTGI
                     SLDDVPLRTTLGELAAL"
     gene            8650..9878
                     /locus_tag="HEP86_RS38575"
                     /old_locus_tag="HEP86_38575"
                     /pseudo=""
     CDS             8650..9878
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-221). E-value:
                     1.5e-19. Score: 62.1. Matches aSDomain:
                     nrpspksdomains_HEP86_RS38575_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091575.1"
                     /locus_tag="HEP86_RS38575"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38575"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /pseudo=""
                     /sec_met_domain="ketoacyl-synt (E-value: 1e-42, bitscore:
                     145.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="t2fas (E-value: 1.8e-54, bitscore: 183.9,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGQCRDVAVTGLGVISPAGTGARATWDSLLTGRSTAARDPGLAG
                     LPVDISCQVPDFDTARLVGRKAAWRLDRFVAMALLAARHAVADAGLDPTEWDASRVGVV
                     MGTGTGSMERYVTEFAKLAAGRPLDISPLAITRSVPNMAAAEIALDLTATGPNFAVSTA
                     CASGSSALGIARDLLRAGTCDLVLAGGAESARHPIPAACFHRMGALSRRTDDPAGACRP
                     STPHATVSSSPKAPRCWCWNTRSTPPPAVRERGRSWSATGRAATPTTTRLRTPRAGAPW
                     RP"
     aSDomain        8845..9312
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS38575_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.50E-19"
                     /label="HEP86_RS38575_PKS_KS.1"
                     /locus_tag="HEP86_RS38575"
                     /protein_end="221"
                     /protein_start="65"
                     /score="62.1"
                     /tool="antismash"
                     /translation="KAAWRLDRFVAMALLAARHAVADAGLDPTEWDASRVGVVMGTGTG
                     SMERYVTEFAKLAAGRPLDISPLAITRSVPNMAAAEIALDLTATGPNFAVSTACASGSS
                     ALGIARDLLRAGTCDLVLAGGAESARHPIPAACFHRMGALSRRTDDPAGACR"
     CDS_motif       9112..9159
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEP86_RS38575_0001"
                     /evalue="2.10E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="HEP86_RS38575"
                     /protein_end="170"
                     /protein_start="154"
                     /score="10.8"
                     /tool="antismash"
                     /translation="GPNFAVSTACASGSSA"
     gene            10001..11296
                     /locus_tag="HEP86_RS38580"
                     /old_locus_tag="HEP86_38580"
     CDS             10001..11296
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091574.1"
                     /locus_tag="HEP86_RS38580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38580"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_168483135.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.7e-48, bitscore:
                     162.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRRTGATASRTPCETGPPPPGPRPGTAVPHRADTGSAGLGPDIV
                     DADVPAAVGRMLVGVLDEQVARAAGIERTFARDVAARVARFTLDGGKRTRSQFLWWGLR
                     SCQDRPGAGDVETALRVAAAVELLQTCALIHDDAMDRSPLRRGRPAVHAAFAGQYATPD
                     TAEAAGRFGTAAAVLAGDLALVWADDTVAGAELGAEAGPRVRHLWRAMRMETVAGQYLD
                     LYGQITGSRSVALAVRTAYLKSARYSVERPLALGAALAGADEPTTRALSAAGRCAGVAF
                     QFQDDLMGVFGDQERTGKPSGGDIREGKHTYLLAVGRARAVQRRDRAALALLDRCVGDS
                     GLDAADLERVRAVLVATGAPGLVERRIHRLVARSIRHLDEAAPEPAAAARLRGLFASVA
                     GLRTATGHPRPAARTGGASAPVPARVAERGTV"
     gene            11293..12828
                     /gene="crtI"
                     /locus_tag="HEP86_RS38585"
                     /old_locus_tag="HEP86_38585"
     CDS             11293..12828
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091573.1"
                     /locus_tag="HEP86_RS38585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38585"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_168483136.1"
                     /sec_met_domain="DAO (E-value: 5.5e-17, bitscore: 61.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVKGPTDHVVVVGAGLSGLAAALHLLGAGRRVTVVERAALPGG
                     RAGRIESRGYHFDTGPTVLTMPDLIDEAFAAVGERLTDRMELRALHPAYRARFADGSEL
                     DVHTDAEAMAAEVARFAGPRAADGYRRLRRWLQQLYDVQRHRFIDTNFDSPLQLLHPDL
                     ARLAALGGFGRLDDRIGRFLPDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAGV
                     YFPRGGMYALPRAMADAAADAGAAFRYGHPVTRLERTGDRITAVVTAHERIPCDAVVLT
                     PDLPVVHRLLGRRPRRPVRLRHAPSAVILHAGTDRTWPRLAHHTLSFGAAWERTFDELT
                     RTGRLMSDPSLLLTRPTATDPQLAPPGRHVHYILAPCPNTDTGPGAGEWRDLAPRYRDS
                     LLAVLERRGLTGIDSAIEEYRMVTPADWTAQGLAAGTPFSAAHTFAQTGPFRPRNLVRG
                     TANAVLAGCGTTPGVGVPTVLISGKLAAARITGLRPPRPTAGSSRPATRGIPA"
     gene            12825..>13754
                     /locus_tag="HEP86_RS38590"
                     /old_locus_tag="HEP86_38590"
                     /pseudo=""
     CDS             12825..>13754
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944617.1"
                     /locus_tag="HEP86_RS38590"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38590"
                     /product="phytoene/squalene synthase family protein"
                     /pseudo=""
                     /sec_met_domain="phytoene_synt (E-value: 3.3e-121,
                     bitscore: 402.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.3e-62,
                     bitscore: 209.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARELDAAGVTDPGLREAYAHCRRLNARHGKTYFLATRLLPAAR
                     RPAVHALYGFARWADDIVDDPATGHTPADRAQALDALHRCLDDGLRGGGSSEPVVRAVA
                     HTAAVYGIDHRHFADFMASMRSDLTVTDYPTYADLRRYMHGSAAVMGLQMLPVLGTVVP
                     QEEAAPHAAALGIAFQLTNFLRDVGEDLDRGRVYLPTDLLAAHGVDRALLRWSRDTGRP
                     DPRITAALQAATALTRGVYREAQPGLALLDPVSRPCIRTAFVLYGGILDAVRDDGYAVL
                     HRRAVVSRRRRAATALGGLARLAATRVTA"
     gene            13812..14825
                     /locus_tag="HEP86_RS38595"
                     /old_locus_tag="HEP86_38595"
     CDS             13812..14825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091571.1"
                     /locus_tag="HEP86_RS38595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38595"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_168484268.1"
                     /transl_table=11
                     /translation="MTQEARRAPRLPLRLRRRPELWEQQHPTWRDAKPARIADAVKAAL
                     ARPSGNWFVLGAARDIGAHRAFGRTVAGVEVVAWRDAGGRLIAGPGACPHLGAPLAQGP
                     VRCGILRCRWHGLALDGAPFAGWEPFPAHDDGLLAWVRLDEAGGERPLAQPELPDRPRP
                     AGAVAAVYTGTGRCEPEDVVANRLDPWHGAWFHPYSFVDLTVLDTPAEHGAERPDGLTV
                     QVSFKVAGRAVVPVTALFTAPGPRTVVMRILEGEGQGSVVETHATPLGPDELGRPRTAV
                     IEAIVATSRRPGFALARAAAPALRPLMRAAAGRLWRDDLAYAERRWQLRTSGRHPG"
     gene            complement(14905..16470)
                     /locus_tag="HEP86_RS38600"
                     /old_locus_tag="HEP86_38600"
     CDS             complement(14905..16470)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888661.1"
                     /locus_tag="HEP86_RS38600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38600"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_168483137.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-06, bitscore:
                     26.4, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.1e-10, bitscore: 40.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRQDDGGAARRGRDRRARTVPGPPGRDRAADGGPEVAVIGGGI
                     AGLAAATALAERGVRVTLYERAGVLGGRLAGWPVRLADGSVATMSRGFHAFFPQYYNLR
                     GLLRRVDPGLGMLRRLPDYPLHHRSGLRDSFARVPRTPPWSALGFVALSPSFTWRDLVR
                     IRPGAALPLLDVRVPQIYQQLDRVSAADFLARIRFPEAARHLAFEVFSRSFFADPRELS
                     AAELVLMFHIYFLGSSEGLLFDVPGEPFPQALWQPLGRYLEGHGVRLCTGTEVTRVAPV
                     KAGGGVLVADGEGAERRFDAVVLALDPGGLRRLVATSPEVADAAWRARIGRLRTAPPFL
                     VSRLWLERRVAADRPGFLGTSGFGSLDNVSVLERWEGEAARWSARTGGSVLELHAYAVA
                     PGADRERAQRRLVEQLHAVYPETRGVRIIDRRHEWRADCPLFPVGGFHDRPTVHTPDPR
                     VVVAGDTVRTGFPVALMERAATTGFLAANALLARWGLRGQTLWTVPDRGRSAALRWAAR
                     RAGR"
     gene            complement(16467..17195)
                     /locus_tag="HEP86_RS38605"
                     /old_locus_tag="HEP86_38605"
     CDS             complement(16467..17195)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091569.1"
                     /locus_tag="HEP86_RS38605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38605"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_168483138.1"
                     /transl_table=11
                     /translation="MALLHDGELTAAFDHASRSYDRLVAVNPGHHGQLRRSVRRLGLPD
                     AGRGLRVLDLGCGTGASTAALLAVAPYAEITAVDASAGMLARAAGKPWPPGVSFVHAPV
                     ERLADAGVAGGFDAVFAAYLFRNVTDPDVVLGAVREALVPGGRLAVHEYTLTGGAVPRA
                     VWTAVCTGILRPAGRLAGDAGLYRHLWRSVLAFDTAAEFTGRLRRAGFGQVRALPLPGW
                     QTGITHTFVAATAGAREEGA"
     gene            complement(17261..18450)
                     /locus_tag="HEP86_RS38610"
                     /old_locus_tag="HEP86_38610"
                     /pseudo=""
     CDS             complement(17261..18450)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091568.1"
                     /locus_tag="HEP86_RS38610"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38610"
                     /product="lycopene cyclase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQDADAVIVGAGAAGLSLAHRLCAPAAGGRPLRVVLVDAPRGPLT
                     RRSGPGVTGRRRAARSTRP"
     misc_feature    18635..18651
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.37"
                     /tool="antismash"
     misc_feature    complement(18637..18649)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            18664..19251
                     /gene="sigK"
                     /locus_tag="HEP86_RS38615"
                     /old_locus_tag="HEP86_38615"
     CDS             18664..19251
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene="sigK"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091567.1"
                     /locus_tag="HEP86_RS38615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38615"
                     /product="ECF RNA polymerase sigma factor SigK"
                     /protein_id="WP_085926039.1"
                     /transl_table=11
                     /translation="MPVAARGDRSPAPHTGALESLLTRVSRGDQYAFEQLYTAVAGSVL
                     GLVRRVVRDPAQSEEVAQEVLIEVWRSAARFDARQGSAMAWIMTLAHRRAVDRVRSVQA
                     AADRDHRAGMGAYTAPFDEVSEQVERRLEREQVRRCLQQLTDLQRESVTLAYYRGYTYR
                     ETADLLGAALGTVKTRLRDGLIRLRDCLGVSA"
     gene            19248..19994
                     /locus_tag="HEP86_RS38620"
                     /old_locus_tag="HEP86_38620"
     CDS             19248..19994
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091566.1"
                     /locus_tag="HEP86_RS38620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38620"
                     /product="anti-sigma factor"
                     /protein_id="WP_168483139.1"
                     /transl_table=11
                     /translation="MSTVDLHTLTGAYALGALSEQESAEFTRHLAQCPACYQEVRELQE
                     TAARLALAVAEVPPAGLRTRVMAALPEVRQLPPRGRHATVVPLRRGMRHRLPYLAAAAC
                     LVVAALAGGLAVQAQTEADEQRDRSVRAEQQAAAVSALMTAPDATFHTTALKGGGSGTV
                     VASQRRGQTAFLYHGLPALSGQRVYELWYSRNGAMEPAGLVRTGSTSGAMLLTGGPQGA
                     DGVGVTAEPQGGSSRPTTAPLAVLRL"
     gene            20213..21484
                     /locus_tag="HEP86_RS38625"
                     /old_locus_tag="HEP86_38625"
     CDS             20213..21484
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010057140.1"
                     /locus_tag="HEP86_RS38625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38625"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_168483140.1"
                     /sec_met_domain="DAO (E-value: 3.1e-07, bitscore: 29.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVERRQIAVVGGGVAGLTAAYVLQQGGCEVSLYEAEDRLGGHAH
                     THDRSSADGRVLRIDTGFIVHNERTYPLLLRLFRELGVATQDSEMSMSVRCEGCGLEYA
                     GARGPAGLFARPSSALRGRYLRMLTEIRAFHRAARTTLATDRGDTLTLGRFLTRCGFSR
                     YFVTHFVTPLVSAVWSCAPTTAMQYPAVYLFRFLAHHGLLSVGGSPRWKTVTGGSVEYV
                     SRIGKQLPAVHTGTPVRAVHRAPDRARIVTEDGTERSFDAVVVAVHPDQALRILADPTA
                     DERQILGAFRYSRNPTVLHSDTALLPRARGARASWNYLMASCTTPADEVRVSYHMNRLQ
                     RLDTPEDFIVTLNATDRIDSDRVLARMVYEHPLYTPESVAAQQRLPQLNTAVTAFAGAY
                     HGWGFHEDGCRSGVHAAAALGVRW"
     gene            21481..22248
                     /locus_tag="HEP86_RS38630"
                     /old_locus_tag="HEP86_38630"
     CDS             21481..22248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091564.1"
                     /locus_tag="HEP86_RS38630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38630"
                     /product="DUF1365 domain-containing protein"
                     /protein_id="WP_168483141.1"
                     /transl_table=11
                     /translation="MTPGTTAPATGPATHTPALYACLVSHARTAPLRYSLRHRTYLWLI
                     DLDHPPRLPAVLRPLARFDARDHFGGTAPSIRAGLERFLTSRGVRLDGGRVLMLAHARV
                     LGHVFNPLTLYWCHDRHSVPVCVVAEVHNTYGERHCYLLHTDAQGRAEVAKDFYVSPFF
                     PVDGAYRMRLPAPAGRLDLTVQLRRGAARPFTATVRGTRQPATAGRLLAAALRHPWSTA
                     AVSLGIRRHGIALFLRRLPIRPRPHHRIQEGMK"
     gene            22245..23561
                     /locus_tag="HEP86_RS38635"
                     /old_locus_tag="HEP86_38635"
     CDS             22245..23561
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091563.1"
                     /locus_tag="HEP86_RS38635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_38635"
                     /product="cyclopropane-fatty-acyl-phospholipid synthase
                     family protein"
                     /protein_id="WP_168483143.1"
                     /transl_table=11
                     /translation="MKTSVSDRTESAAVVPAAAPTPAHPRVDAATWPDVMRGPRGSAAR
                     TAVTRLLVQRALAALPLRIALGDAPVTGAEGPLVRVHDPEAFFRRIGTDGLIGFGESYM
                     AGEWEADDLVGALTVLAAHLTSLVPPPLQRLRGAWARRRPSAQRNTLEGARQNIHRHYD
                     LSNDLFALFLDPTMTYSSAVFRQGPAVWGDLADAQHRKIDRLLDLAGVGDGTRLLEIGT
                     GWGELALRAAARGARVVSVTLSQEQRDLALARIAQAGHADRVSVELCDYRQVTGRYDAV
                     VSVEMIEAVGEDYWPVYFDTLERLLRPGGRIALQAITMPHARMLATRTTYTWIHKYIFP
                     GGLIPSAEAIAQHAAAAGLRVRENDGYGGHYAETLRLWRERFTQRAAAVGTLGFDPVFR
                     RMWEFYLAYSEAGFRAGYLDVRQLLLTRATTTAPDGGPR"
ORIGIN
        1 ggtccttgac cagatgcggg gcgacctgcg cctggatcga gatcaccgac atgtgatggg
       61 cgaccacgtc gtgcagttca cgggcgatcc ggttgcgctc ctccagcagg gtgcgccggg
      121 cccgctcccc ggcggtgaga acctcctgct cgacgagctg gtgacgggcc acccggcggc
      181 cgcgcagcgc ggcgcccagc accaccgctg ccgtgaaggt caccgcatcc tggaggaccg
      241 tcacgtcctg ggcggaggac gcgaggaccg gcggggccgc acccggcaga aggctcgggt
      301 ccggtaccgg ccccaagaag gccagtgcgg ccaccgccgc cagaagcgag aaccccagcg
      361 cctcggccgc gatacggggc cggacccgca gcgccagaag gaacagcacc agggcgtgca
      421 gggcgatgcc cgggatgctc caggaccaca gggcgtcatg gctggtcttg accccgccga
      481 cattcctgac caggaagagc gcgatcgtcg acagccacca ggcgggcacc gggcgggaca
      541 gcgcgaggac tacggcgccc gattggagca ccgccagcgt caccacggtg gtcaccgcga
      601 acggcccgaa atccaccttg taccggtcgg cgttgagcca gcccatgagc accgcggcca
      661 gcaccacatg gccatgcggc agccggccca gccagcgcat ccggggcagt ggatcgcgcg
      721 ccacggtcca cagatccgcg cgcagggtat gcggcagccc ccgcacggcc gcccacagcc
      781 gcggcccgct gctcttccaa cccccctggc tcacacggtg catcctaagc acgccgcacc
      841 gccccgacct cagcgggacg ccccgcccgg accaccatgc tgctgccgcg gcgccgcccc
      901 tgctcgtacg tgcggaacgc ggaccagcac accagcagcg ccagcgcgaa caccggcagc
      961 cagcccagcc gggcgaggac ccagccggca ccgtcgggaa gggtgtgcag accgggcagg
     1021 aacccgccgg tgagcagacc gaccgcggtg accgccatca tcgcggtctg gtgccacagg
     1081 aagagcgtca tcgccgagag gttcatcagc gccaccgccg cccagacggc ggggcgttgg
     1141 agcagccgct gcagggggcc gagcagcagc agggccgccc cgcactgcgc gagaccgaag
     1201 gtgaccgccg cgagggtggg cgggttgagg ttggatatca cggcgccggg caccccgacc
     1261 atggcggccg ggtagccggc ccacaggacg agtccggcgg tggtggcggc gccgccgagc
     1321 agcagcaccc atgccgtcgc ccggctccgc agcccgcccc gggcccaggc cgcgcccagg
     1381 cagtacggca ccagccagcc ggccgccaca ttggtccagc cgagccaggc cgggccgccg
     1441 agcccgaacc ggagcagatc gatgtgcagg acgacggcga gcggccacag cggatgcagc
     1501 cgggcggcca ccggagtcgc cgccgtcagc gcggcgaaca ccagcaggaa ccagagcggg
     1561 gacagcgcca gtttgccgag ggtgtggacg gtgtccagac cggcccccgc gacgagcagc
     1621 ccgcccgcca cgacgctcca gacgaccagc atggccgcca cgggccggaa cagccgggcc
     1681 atccgggcgc cgagccaccc acggtaggtc ccgccccggg cgcgggtggc ggcatagctc
     1741 gtcgccgcca tctgaccacc caccagaaag aagaccgcca gggtctggag aagccaggag
     1801 accggggtga ggtgcggcag ctcgtggagg gggctgacga cccgcaccgt gccgctgtcg
     1861 gcgaccagcg cggtcaccag ccagtgtccg agcatcaccc cgagaatggc gagcgcacgc
     1921 agggcgtcga caccgcggtc acggtcggcc ggtgtcgcgg cgtcgatccg ccggatgagt
     1981 tcacgcatcg ctgctctcct cggaaggggc ctggccggac acgatccggg cgaggttccg
     2041 cagggacacg gaaccgggcg tgaggtagtc gctgtggccg ccaggacccg ccgcgaagac
     2101 ccgggcgccg aactccggcg cgaccggatc ggctcccaac ccgagggtcc cgaaggggag
     2161 ttgcagctgt ccgtgcggca catcggcgat ccagtcgtcg tcgccccggc cggcccacac
     2221 cgtcgccggg gtgtgcagcg ccgcgacgtt ttcggcgccc gcgccggggc tgccgaacag
     2281 caccaggtcc gcgacatcca gccccggcgc cgcccggcca cagaccacgg ccccgtacga
     2341 atggcagagc acggagagcc gcgccgtggg acggagcttc gccacggcac cgacgaaggc
     2401 gcggagtccg ggagcggcct ccgccgcgcg gccgggggtg aggacgtcgg gactcaccgt
     2461 gctcggcgtc cggtacccga cccaggcgag gaccgcggac cggccgccca actcccgctg
     2521 gagcgccagc gcgccggacc gcagacgtgc gtaccggtcg aggtgggtgt ccgagcccgg
     2581 caccagtacg gtgatccggt cggcccgtgc caggtcgccg aagacctcgg tggtgcggcc
     2641 tccgtcgcgg ccgtcgaaga acaggaactg ccgctccggg ccggccatcc cgcgcagtac
     2701 cccggcccgc gcccggtcgc cgtggccctc ggccatccgc tccgccgcgc ggatcccctc
     2761 gcggtttacg gcgtagcgct cggcgagcgc accgggggcg gcggaccgca gcggagcgag
     2821 ggccttgggg gcgggtgccg ggacggccgc ggggcgggcc gcacccgaga cgggcaccac
     2881 caccgcggtg acgacgaaag cggcgagcag agtgcgcagc ggacggctgc cgcgcgggcg
     2941 ggacgccatg atggatggtc cttccgtacc ggaagccggt cgtggcttcc ggtaccgaag
     3001 ctatggagca gggcacttgg tcgacgtccc gccagggagc gtacttcggt ggtagctctc
     3061 aggtatcagg ggtagggggc ggcggtgctc gacctcgcgg aagagcgcct cggctgtgcg
     3121 ccggtatccc cggtggtgcg tccggcgtgg acgacgcggt cccgcgtgcg ggcccggcgc
     3181 gccgccggac ccctcacgtg cgcgcaaggc gttcgtcccg gccctaccgt gtcgccatgg
     3241 tgcgtgccga ccggccccgg gccgaccgac cgggcagacc tgcggcgccg ggccggccgc
     3301 cggctccgct tctggcggtc tgcgcgggct acttcatggt catcctggac gtgaccgtca
     3361 tcaacgtcgc cgtcccggtg gtggggcggg aactgtccgc ctcgctcacc gggatccagt
     3421 ggatcaccga cggctacacc ctggtcttcg ccggtctgct gctcaccggc ggcgcgctgg
     3481 gggaccggct gggcaaccgc cggatcttct gcaccggcgt ggtggtcttc acgctcgcct
     3541 cggccgcctg cggcctggca ccgaccagcg gggccctgat cgccgcccgg ctggtggaag
     3601 gactcggcgc ggccctgatc gtccccggct cgctcgccct cctccaacag gcgtatccgg
     3661 cacccgccga gcgctcccgg gccttcggcc tgtggggctc catggcgggg atcgcggcct
     3721 ccgccggacc cctgctgggc ggcctcctgg tcaccaccgt gggctggcgc tgggtgttct
     3781 tcatcaacct gcccgtcgga tgcgcctgcc tgctgctgac gctgcgtcat gtctccgctt
     3841 cggcgcggcg tacggaccgc cccctggact ggcccgccca gtgcgcgctc atcgccacgg
     3901 tcgccctgct caccaccgtc ctcaacgagg ccggacgccg gggctggacg gacccgctga
     3961 tcctcaccgg agccggcctg tgtctgctgt cggccgccgc gttcgtgctg cgcgagcgcc
     4021 tggcacgcac ccccgtgctg ccgctgcggc tgctgcgctc ccgcccgatg agcggggccg
     4081 cggccatcgg actcctcttc aacttcgcct tctacggcat gatcttcacc gccagcctgt
     4141 acttccagca ccaccgcggc ctgaccgcgc tgcgcaccgg gctcgccctc ttcccggcgg
     4201 tggccatgac catgttcgcc tccgtcctgt ccgggcggct ggcccgccgt accggacacc
     4261 gcccgctcgt ggtcaccggc atgctgctgg gcgcggcagg tctggccggc tgggcggccg
     4321 ccggaccgga tccggactac ctgctgctcg tggggccgat gatggcggcg ggcttcggca
     4381 cgtccttcgc cctcaccgga gcgaccgcca cggtgatgtc ggccgccccg gacgcgtact
     4441 ccggtaccgc ctccgcactg ttcaacacca cccgccagat cggcagcgcg gcaggcgtcg
     4501 cgctgggcgg ctccctgctg gccgcggcgg ccggcttccc ggccgggctg cggacgagca
     4561 tggccatcgg cgcggccgcg tatctgatgg ctgccgtgct cgcggtcctc tgcgtcccgc
     4621 cgaaggggca caaaagccgg gccgccggct gacgggcggc gggccgcggc gtacagcctg
     4681 cggtgatatg ccgtggtatg tacccaggac cggccggtcg cccggcgagc gatgagttct
     4741 cgccgtcctg ggagtccacc ccctgtaccg gcagatttcc gcacccgaag ggcagcacca
     4801 tgagcacact gatcgtcacc gcgttcgtca ccctggacgg cgtcatgcag gcccccggcg
     4861 gcccggacga ggacgtcgac tccggcttca cacacggcgg ctggcaggtc ccgtatgtcg
     4921 acgacgactt catgggcctc atgaccgggg tcttcgagca caccgccgac catctcctgc
     4981 tcggccggaa gacctacgac atcttcgcca cctactggcc gcgcgtcacc gacccggaca
     5041 acccgatcgc ggtgaagctc aacagcatgc ccaagtacgt cgcctcacgc acccggaaca
     5101 gcctggagtg gaacaactcc cagctgctgg agggcgacgc cgccgaggcg gtcgcccggc
     5161 tcaagcagga actcgacggt gtgctcatga cccagggcag cagcgacctc atccgcaccc
     5221 tccagcagca cgacctcgtc gacgagtacc ggctgctgat caacccggtg atcctcggca
     5281 ccggcaagcg gctgttcgcc gacggcgccg cccccaccgc ctggcggctc acggaatccc
     5341 gcaccaccgg cgcgggcgtt cagtactgcg tctaccagcg ggccgggaag cccgagtacg
     5401 gcaccttcga gctcgacgag caggactgag gacccggccg gctcccgcgc ggcggccggg
     5461 cccggctgcc gccgttggtg tcagaggggg acggcgcctt gcgtggtgtg tggagtgcgg
     5521 gggcggggga gggcagggtc ggcgtgggca ccggtccggg gtccggccgg aggtctccgg
     5581 accccgcagg gcggcgggcc gcgcggccgg tccgtggggc ggccggcggt gcacgggcgg
     5641 agcccggacc agtggagcgc gaggcgaagg gcgtgtgtcg tgggtgtcgg tttcgcagaa
     5701 gagtcgacgt cggtgacggt agcggcgtcg gcggtgccgg agcgtgtcgt gctggctgcc
     5761 cgtccgcagg cggcgctgcg cctgtattgc gtgccgcccg ccggggccgg cccggactgc
     5821 tatctgcgct gggcgccgct gctgccgccc tggatcgagc cgtgctccgt ggcgctgccc
     5881 ggccgcggca cccgcgccgc ggaaccctcg ctgaccgacc ccgcgtatct gagcgcccgg
     5941 ctcgccgcgg tgctggacga ctggaccgac ccccggccgt tcgcggtctt cggacacagc
     6001 gcgggcgccc tgctggccta cgaggcgacc cgccatctgc ggcgcaccca cggccggctg
     6061 ccgtcgctgc tggcggtgtc ctcactgtcc gcgccgcata tcgacgccta cagcgccggc
     6121 ctgccgcccc ggttgaccgc cggactggaa ggcatccgcg aactcgtcgg cccgatcccc
     6181 gaccaactgc tcgccgacgc ccgcctgatg gccgcggcct gcaccccgct gctggccgac
     6241 tgtctgctgc tgctgcacta ccggcaccgc cccgaaccgc cgctcgacgt accgctggcc
     6301 ctctacggcg gggaacacga ccccgtcacc agcgtcccgg acctccaggc ctggaacgac
     6361 ctggtcacca caccggcccc ggtccagctc ttccccggcg ggcacaccta cctccagacg
     6421 gagaccaaag ccctggtgga ccggctcacc gagaccctcg acccggcccg gtacgcccgc
     6481 cccgtggcga cggcatgacg gccgccgtgc cggcccgcac cccggcccca cccgtacgcc
     6541 gggcggcagc ggccgccgtg gtgtgcctcg gactcttcat gctgggcctg gatctgacgg
     6601 tcctcaatgt cgcggtgccc gaccttcagg gcggcctgga aacctccacc gcgcaggtcc
     6661 agtggatcgt cgacggcttc gccctggtcc tgggcggcac ggtgctggcc gtgggcgcct
     6721 tcaccgacgc ctggggccgg cggcgttcct tcgtctgcgg ggtggcggtc tgcggaggcg
     6781 cctcgctggg cggtgcgctg gccgcccagc cgtggcaggt gatcgccgcg cgctgcacca
     6841 tgggagccgg ggccgcgctg ctgatgccgg cgacgctggc ggtccttcac caccttttcc
     6901 cagagccccg gttgcgcagc cgggcgatcg ccgcctgggc cgcggtcggc ggtatgggcg
     6961 gcctgtgcgg tccggtcatc ggcggcgggc tggtggagca cttctcctgg cgcgccgcct
     7021 tctggatcaa cctgcccctc gccgccgtca tcatcgtgct ggccctgctc ctggtacccg
     7081 agtcccatac gcggcggcgg gccggcttcg atgtgcccgg tgccgcgctg tccgccgcgg
     7141 ggctgctggt cctggtgtgg tccatcaccg agagcccgca ccgcggctgg accagcccgg
     7201 ccgcgctgac cggattcgcc gccgccgcgc tgctgctggc cgcgttcgtc cgccgccagc
     7261 tgcacgcccc cgcacccatg ctcccgctgt ccctgctgcg ggtgccggcc atcggggtgg
     7321 ccgcggcggc cctggcgctg atgtccttcg cgatgttcgg cgcgctgttc gtgctgaccc
     7381 tctacctcca gggcgtactg ggcttcagcc cctggcaggc cgggctgcgg acgctgccgc
     7441 tgcccgccgg gctggcactc ggtgcggtgt gcgcggtgcc ggtacgggcc cggctgggcg
     7501 gccgggtccc cgtcgtgggc ggactggccc tggtgacggt cggcttcgcc atcctggcga
     7561 ccaccacccc ggactccgac tacccgcact gcgcggcctt ccagctggtg gcgggcttcg
     7621 gcgccgggct ggtggcggcc gcggccaccg aatcggtgat gggctcggtc gccaccgaac
     7681 gagccggact cggctcggcc atcaacgacg ccacccgcca ggtcggttcc gccctcgggg
     7741 tggccgtcca gggctccctg ctcgctgccg tcttcacctc ccggctcacc gcctccctca
     7801 ccgatctgca cgcccccgcg ccggtggccg ccgcggcccg gcacagcatg ctgtcggtcc
     7861 ccgcacaggc gatgcggctg cccggcccgc tgcgcagcag tgtgctgtcc gccgcgcgac
     7921 gcgccttcac ggacgccatg acgctgaccg ccgtcgtcgc cggagccgtc accctgctca
     7981 ccgccgcggc cgccgcccgc tggctcggcc gcccggaccg ccaggacggc gcgccccggc
     8041 ccgccggcgc ccggctgcac ggaccgcagc cggcgcccag ggaagaggag cgtccggcgc
     8101 tatagagcga taagtcactc gttcagaggt gccttcatga accgggccgg aggagccggt
     8161 cggcgacagt agagcgcgag cccgacccct gcgcaccggc ccccggtgcc ggccgccccc
     8221 gcccgcctgg agccacgatg cacaccccgt ccgcacccgc actcaccacg gtgccccggg
     8281 ctccttccgc gcggcctcgc ggtgcctgtc ggaaacgacc tcccgcctcc ggacagcgcc
     8341 ccgcccacgg cggccggcac caccacccca accgaaggag ccacccgtgc ccaccagtgc
     8401 agagctgatc accagcaccc tcaccgagac ctttgacctc gacccggccg aggtcatgcc
     8461 cgagtgcacc ttcgaggacc tcggcctgga ctccctcgcg ctggtcgaga tgggcctgat
     8521 gcttcaggag cgcaccggga tctcgctgga cgacgtgccg ctgcggacga ccctcggcga
     8581 actcgccgcg ctgatggaca gcggtacggc cggccaggcc ctgaccaccg cgccgaacag
     8641 cggcagctga tgcccggtca gtgccgtgac gtcgccgtca ccggtctggg cgtcatcagc
     8701 ccggccggga ccggcgcccg ggccacctgg gactccctgc tcaccggccg gtccaccgcc
     8761 gcccgggacc cggggctggc ggggctgccg gtggacatct cctgccaggt gcccgacttc
     8821 gacaccgcgc gcctggtcgg ccggaaagcc gcctggcggc tggaccgctt cgtggccatg
     8881 gcgctgctcg ccgcccggca cgccgtcgcc gacgccggtc tcgaccccac cgagtgggac
     8941 gcctcgcggg tcggcgtggt catgggcacc ggcaccggga gcatggagcg ctatgtcacc
     9001 gagttcgcca agctcgcggc cggccgcccg ctggacatct cgcccctcgc catcacccgc
     9061 agcgtgccca acatggcagc cgccgagatc gccctcgacc tgacggccac cgggcccaac
     9121 ttcgccgtct ccaccgcctg cgcgtccggc agcagcgccc tcggcatcgc ccgcgacctg
     9181 ctgcgcgccg ggacctgcga cctggtgctg gccggcggcg cggaatccgc ccgccacccc
     9241 atccccgcgg cctgcttcca ccggatgggc gcgctgtccc ggcgtacgga cgaccccgcg
     9301 ggcgcctgcc gcccttcgac gccgcacgcg acggtttcgt cctctccgaa ggcgccgcgg
     9361 tgctggtgct ggaacacccg gagcacgccg ccgcccgcgg tgcgcgagcg cgggcgcagc
     9421 tggtcggcta cggggcgagc tgcgacgcct accactacgc ggctccggac cccgagggcc
     9481 ggggcgccgt ggcggccctg accgcggccc tggccgacgc cggtctggcg ccccgggaca
     9541 tcgatcacgt caatgcgcac ggcaccggca cccgcctgaa cgacctggcc gaagccaggg
     9601 cgctgcgcgc cgtcttcccc gagccgcccg ccgtcacctc cctcaagggc gcgctcggcc
     9661 acgccatcgg agcggcgggc gccatcgagg cggccgtcac ggtcatgagc ctccaacagg
     9721 acaccatccc gcccaccgcc aaccacgagg accccgacct cgatatcgac ctggacatcg
     9781 tggccaaggc gcctcgccgt acgcccctgt ccgccgccgc cagcacgtcc ttcggcttcg
     9841 gcggccagaa cgccgccctc gtcttccggt ccgcctgacc cgctgaccgg gccgcgcacg
     9901 gccacctgcc ccaccccgtc gcacccggcg gcgcgctccc cggaaccggt gcgcggcccg
     9961 ccgccgacct ccgccgaccg acgcgccgag aggaaccacg atgcgccgtc gtaccggggc
    10021 taccgcgtcc cgcacgccgt gcgagaccgg cccgccgccg cccggtccac gccccgggac
    10081 ggccgtaccg caccgtgctg acaccggctc agccggtctc gggccggaca tcgtcgacgc
    10141 ggatgtgccg gccgccgtgg gacggatgct cgtcggcgtc ctcgatgagc aggtcgcgcg
    10201 ggcggccggg atcgagcgca ccttcgcccg ggatgtcgct gcccgggtcg cccgcttcac
    10261 cctggacggc ggcaagcgca cccgctccca gtttctgtgg tgggggctgc ggtcctgcca
    10321 ggaccggccg ggcgccggtg acgtggagac ggcactccgg gtggccgccg ccgtcgaact
    10381 ccttcagacg tgtgcgctca tccacgacga cgccatggac cggtcaccgc tgcgccgcgg
    10441 ccggcccgcg gtccacgccg cgttcgccgg ccagtacgcg acgccggaca ccgcggaagc
    10501 ggccgggcgg ttcggcaccg ccgccgccgt actcgccggc gatctcgccc tcgtctgggc
    10561 ggatgacacg gtcgccggtg ccgaactcgg cgcggaggcc ggtccgcggg tgcggcacct
    10621 ctggcgggcg atgcggatgg aaacggtggc cggccagtac ctcgacctct acggccagat
    10681 caccggctcc cgctccgtcg cgctggccgt ccgcaccgcg tacctcaaga gcgcgcggta
    10741 ctcggtggag cggccgctgg ccctcggcgc ggcgctggcc ggggccgatg agcccaccac
    10801 ccgcgcgctg agtgccgccg gccgctgtgc cggggtggcc ttccagttcc aggacgatct
    10861 gatgggggtg ttcggggacc aggagcggac cggcaaaccg tccggcggcg acatccggga
    10921 aggcaagcac acctatctgc tcgcggtcgg ccgggcgcgc gccgtgcagc gccgcgaccg
    10981 ggcggccctc gcgctcctcg accgctgtgt cggtgacagc gggctggacg ccgccgacct
    11041 ggagcgggtg cgcgccgtcc tcgtcgccac cggcgccccc ggcctcgtcg aacggcgtat
    11101 ccaccggctg gtggcccgca gcatccgtca tctggacgag gccgccccgg aacccgccgc
    11161 ggccgcccgg ctgcgcggcc tcttcgcatc ggtcgccggg ctccgcaccg ccaccggcca
    11221 cccgcgcccg gcagcacgaa ccggcggcgc atccgcaccc gttcccgccc gggtggccga
    11281 aaggggcacc gtatgagaac cgtcaagggc cccaccgacc atgtggtggt ggtcggtgcc
    11341 gggctctccg gactggccgc cgcgctgcat ctgctcggcg ccggacggcg ggtgacggtc
    11401 gtcgagcggg cggcgctgcc cggcggccgg gccggccgga tcgaaagccg tggctaccac
    11461 ttcgacaccg ggccgaccgt gctgaccatg ccggacctca tcgacgaggc gttcgccgcg
    11521 gtcggcgagc gcctcaccga ccggatggag ctacgggccc tgcaccccgc gtaccgcgcc
    11581 cggttcgccg acggcagcga actggacgtc cacacggacg cggaggccat ggcggccgag
    11641 gtcgcacggt tcgccgggcc ccgggcggcc gacggctacc gccggctgcg ccgctggctc
    11701 cagcagctgt acgacgtcca gcgccaccgc ttcatcgaca ccaacttcga ctcacccctc
    11761 cagctgctgc acccggacct ggcccgcctc gccgcactcg gcggcttcgg ccggctcgac
    11821 gaccgcatcg gccgcttcct gcccgacgag cggctgcgca gggtcttctc cttccaggcg
    11881 ctgtatgccg gggtaccgcc cgcgcgcgcc ctggccgcct acgccgtcat cgcctacatg
    11941 gacaccgtcg ccggggtgta cttcccccgc ggcgggatgt acgccctgcc ccgggccatg
    12001 gcggacgcgg ccgccgacgc cggtgccgcg ttccgctacg gacaccccgt cacccggctg
    12061 gaacgcaccg gcgaccggat cacggcggtg gtcaccgcac acgagcgcat cccctgcgac
    12121 gcggtggtcc tcacccccga tctgccggtc gtccaccggc tgctcggccg ccgcccccgc
    12181 cgcccggtcc ggctccgcca cgcaccgtcc gcggtgatcc tgcacgccgg caccgaccgg
    12241 acctggccgc gactggcgca ccacacgctc tccttcggcg ccgcctggga gcggaccttc
    12301 gacgaactca cccgcaccgg ccggctgatg agcgacccct cgctgctgct cacccgcccc
    12361 accgccaccg acccgcaact cgccccgccg gggcggcacg tgcactacat cctggcgccc
    12421 tgccccaaca ccgacaccgg ccccggcgcc ggggagtggc gcgacctcgc cccccggtac
    12481 cgcgacagcc tgctcgccgt cctcgaacgc cggggactca ccggcatcga ctccgccatc
    12541 gaggagtacc gcatggtcac cccggccgac tggacggccc agggcctcgc cgccggaacg
    12601 ccgttctccg ccgcccacac cttcgcgcag accggcccct tccgcccccg caacctcgta
    12661 cgcggcacgg ccaacgcggt actggcgggc tgcggcacca ccccgggggt cggcgtcccc
    12721 accgtcctga tctccggcaa gctcgccgcg gcccggatca ccggcctgcg gcccccacgt
    12781 cccaccgccg gttcgtcccg ccccgccacg agaggcatcc cggcatgacc gcacgcgaac
    12841 tggacgccgc aggcgtcacc gaccccggcc tccgtgaggc ctacgcgcac tgccgccggc
    12901 tcaacgcccg gcacggcaag acctacttcc tcgccacccg gctgctgccc gcggcccgcc
    12961 gcccggccgt acacgccctc tacggcttcg cccgctgggc cgacgacatc gtcgacgacc
    13021 ccgccaccgg ccacaccccc gcggaccgcg cccaggcgct cgacgccctc caccgctgcc
    13081 tcgacgacgg tctgcggggc ggcgggagca gcgaaccggt ggtgcgcgcg gtggcgcaca
    13141 ccgctgcggt gtacggcatc gaccaccgcc acttcgcgga cttcatggcc tcgatgcgca
    13201 gcgatctgac ggtgacggac tatccgacgt acgccgatct gcggcgctat atgcacggct
    13261 ccgccgcggt gatggggctc cagatgctgc cggtgctcgg caccgtcgta ccgcaggagg
    13321 aggccgcgcc gcacgccgcg gccctcggca tcgccttcca gctcaccaac ttcctgcgcg
    13381 atgtcggcga ggacctcgac cgcggccgcg tctacctccc caccgacctg ctcgcggcac
    13441 acggcgtgga ccgcgcactg ctccggtgga gccgggacac cggccgcccg gacccgcgga
    13501 tcaccgcggc cctgcaggcg gccaccgcac tcacccgcgg tgtctaccgc gaggcgcagc
    13561 ccggcctcgc cctgctcgac ccggtctccc gcccctgtat ccgcaccgcg ttcgtcctct
    13621 acggcggcat cctcgacgcc gtgcgcgacg acggatacgc cgtgctgcac cgccgcgccg
    13681 tggtctcccg ccgacgccgc gcggccaccg ccctcggcgg tctggcccga ctcgccgcca
    13741 cccgcgtcac cgcccggccg cccgtggtgc ggcccggccg gggtgccgca ctacgcgcag
    13801 gaggaaaccc catgacccag gaggcccgcc gggccccgcg cctcccgctc cggctgcgcc
    13861 gccggcccga gctgtgggaa cagcagcacc ccacctggcg cgacgccaaa cccgcgcgca
    13921 tcgccgacgc cgtcaaggcc gccctcgccc gcccgtccgg caactggttc gtcctcggcg
    13981 cggcccgcga catcggcgcg caccgagcct tcggccgcac cgtcgccggg gtcgaggtgg
    14041 tcgcctggcg ggacgccggc ggccgcctga tcgccggccc cggggcctgc ccgcacctcg
    14101 gcgcgcccct cgcgcaaggg cccgtacgct gcggcatcct ccgctgccgg tggcacggac
    14161 tcgccctgga cggcgccccg ttcgccggct gggagccgtt ccccgcccat gacgacggac
    14221 tgctggcctg ggtacggctc gacgaggcgg gcggcgaacg cccgctggca cagcccgagc
    14281 tgcccgaccg gccccgcccg gcgggcgccg tcgccgccgt ctacaccggc accggccgct
    14341 gcgaacccga ggacgtggtc gccaaccgcc tcgacccctg gcacggtgcc tggttccacc
    14401 cctactcctt cgtcgacctc accgtgctcg acacccccgc tgagcacggc gcggaacggc
    14461 ccgacggcct caccgtccag gtctccttca aggtcgccgg acgcgcggtg gtgccggtca
    14521 ccgcgctgtt caccgccccc gggccccgta cggtggtgat gcgcatcctg gagggcgaag
    14581 ggcagggatc cgtggtggag acccatgcca cgcccctggg cccggacgag ctgggacgtc
    14641 cgcgcaccgc ggtcatcgag gcgatcgtcg ccacctcccg gcgccccggc ttcgccctgg
    14701 cccgcgcggc cgcacccgcc ctgcgtccgc tgatgcgggc cgccgcgggc cggctgtggc
    14761 gggacgatct ggcctacgcg gaacgccggt ggcagctgcg caccagcggc cgccacccgg
    14821 gctgacccag gccggcgggg cgccaaccgg ccccgtcgag ccgcccgccc gcaggcccgc
    14881 cgcctggccc gtagcgcgcc ccggtcaccg ccctgcccgc cgggccgccc accgcagcgc
    14941 cgccgaccgc ccccggtccg ggacggtcca cagggtctgg ccgcgcaggc cccagcgtgc
    15001 caacagcgcg ttcgccgcga ggaatccggt cgtcgcggcc cgctccatca gcgccaccgg
    15061 gaacccggtc cgcaccgtgt cgcccgcgac caccacccgg gggtcggggg tgtgcacggt
    15121 gggccggtcg tggaagccgc ccaccgggaa cagcgggcag tccgcgcgcc actcatgacg
    15181 gcggtcgatg atccggacgc cgcgggtctc cgggtagacg gcgtgcaact gctccaccag
    15241 acggcgctgt gcacgttccc ggtcggctcc cggggcgacg gcgtaggcgt gcagttcgag
    15301 caccgagccg ccagtacggg cggaccaccg ggccgcctcg ccttcccagc gctccagcac
    15361 gctgacattg tccagggagc cgaagccgct ggtgcccagg aaaccgggcc ggtcggcggc
    15421 cacccgccgc tccagccaca gccgcgacac cagaaacggc ggcgcggtcc gcagccgccc
    15481 gatccgcgcc cgccaggcgg cgtccgccac ctcgggtgag gtggcgacga gccggcgcag
    15541 cccgcccggg tccagcgcca gcaccaccgc gtcgaaccgg cgttccgcgc cctccccgtc
    15601 ggcgaccagc accccaccgc ccgcctttac gggcgcgacc cgcgtcacct ccgtgcccgt
    15661 acacagccgg acgccgtgcc cttccagata ccggccgagg ggctgccaca gcgcctgcgg
    15721 aaacggctca ccgggcacat cgaacagcag cccctcactg gagccgagga agtagatgtg
    15781 gaacatcaac accagctccg cggccgacag ttcccgcggg tccgcgaaga agctccggga
    15841 gaacacctcg aacgccagat ggcgcgcggc ctcgggaaac cggatacggg cgaggaagtc
    15901 cgcggcgctg acccggtcca gctgctgata gatctgcggc acccgtacgt ccagcagcgg
    15961 cagcgcggca ccggggcgta tccgtaccag gtcccgccag gtgaagctgg ggctgagcgc
    16021 cacaaagccc agggcgctcc agggcggtgt ccggggcacc cgggcgaagc tgtcccgcag
    16081 gcccgaccgg tggtgcagcg gatagtccgg cagccgtctg agcatcccca gccccgggtc
    16141 gacccggcgc aacagccccc gcaggttgta gtactgggga aagaacgcgt ggaagcctcg
    16201 gctcatggtc gccaccgagc cgtcggcgag ccgcaccggc cagcccgcca gccgtccgcc
    16261 gaggaccccg gcacgctcgt acagcgtcac ccgcaccccg cgctcggcca gcgcggtcgc
    16321 ggcggcgagg cccgcgatcc cgccgccgat caccgccacc tccgggccgc cgtccgccgc
    16381 ccggtcacgc cccggcggcc ccggcaccgt ccgggcccgc cggtcccgtc cgcgccgcgc
    16441 ggccccgccg tcgtcctgtc gaggtgtcac gccccctcct cgcgggcccc ggccgtggcg
    16501 gcgacgaagg tgtgcgtgat gccggtctgc cagccgggca gcggcagcgc ccgcacctga
    16561 ccgaagcccg cccggcgcag ccgcccggtg aactccgctg cggtgtcgaa cgcgaggacg
    16621 ctgcgccaca gatggcgata cagaccggcg tcccccgcga gccgcccggc cggccgcagg
    16681 atgccggtgc acaccgccgt ccacacggcg cggggcaccg ctccgccggt cagcgtgtac
    16741 tcgtgaacgg ccagccgccc gcccggcacc agcgcctccc gaaccgcccc gaggaccacg
    16801 tccgggtccg tgacattgcg gaagaggtac gcggcgaaga cggcgtcgaa gccaccggcc
    16861 accccggcgt cggccaggcg ttccaccggt gcgtgcacga aggagacccc gggcggccag
    16921 ggtttgccag cggcccgcgc cagcatcccg gccgaggcgt cgacggcggt gatctcggca
    16981 tacggggcga cggcgagcag tgccgccgtc gaggcgccgg tgccgcaccc cagatccagc
    17041 acccgcagtc cacgtcccgc gtcgggcagc cccaaccgcc gtacagaacg gcgcagttga
    17101 ccgtggtggc cgggattcac cgcgaccagc cggtcgtagc tgcgggacgc atggtcgaac
    17161 gcggcggtca gttcgccgtc gtgcagcagg gccatggatg tctctcctcc ggtacggggg
    17221 caagcgcggg cgccgacgcg ccgttcggcg ggcagcgggg tcaccgcacg gtggtgcggc
    17281 gggggagcag cgggagttcg gcgacggtgc ggagcatggg cagcaccggg gtgcgcaggc
    17341 cgatgctgac gtcctcccac agccgcgagc ggccgtcgag aaaccgcagc agccgctcca
    17401 tcggcacatc gcggaacagc ccggtgaaga actcggcgcc gtccacccgg ccgctgtcca
    17461 gcgcccgcag cagcacggcg tccatggccc ggtgccaggc ggtgtgcggg ggagggggcg
    17521 ccggagggcg gccggccagc agcgcggccg cgatcagtgc cgtctgccgc tgcacggaag
    17581 cgaaggtgta cccggtcgac ggacgggtgg cgccgcccgc cgtcccgatg cggaacaccg
    17641 cccggcccgc ccggcgcgga aagcggccgt cggtcatcgg gatcgcgccc tgctcgacgc
    17701 ccgtgacacg gaaggcgccc agccgcagca cctgcccggt gtagtggcgc agggcccgct
    17761 cgtagtcggc ggtggccatg gcccggcggg agaactccgt gtactccacc agcgccgcac
    17821 agtcgttgag tggcagcaca tacccgaagg acagaccgtg gccgggctgc ggggtacgga
    17881 agtccatcag atccgcggtg gtggggtcga acgccggacg ccgggtgcgg acgaaccagc
    17941 cccggaagtg ctgctggaga gtggtccgcg ccggcgggag ccgcccggcc ggccgggagt
    18001 cgaaggccca ccgggcccgg agggtcaccg gccgcccggc cgcgtcgcgc ccccgtacct
    18061 cggccccgcc ggtgacgtcc tgtacggact ccaccgtcgc ctcggcccgg accacggcct
    18121 cttgcccggc gagccgggcg gccaccaggg cctcgaagtc acgcgaccgc agcatcttgt
    18181 accggaaggg ctcgggccgc cccgccgtcg cctcgccgcc cggcccgtgc acccgcagcc
    18241 gttcccacga cgcggtcagg gcctggtcga acgcgccgcc cggcgcctcc cagtaacacc
    18301 aggtccgctc cggcgggtga gcggcccccg tggtgcgtcc accagcacca cccgcagcgg
    18361 ccggccaccg gccgccggtg cgcacagccg gtgggcgagc gacagcccgg ccgctcccgc
    18421 gcccacgatg acggcatccg cgtcctgcac gcccggtcct ctcgccgccc gatgcccccg
    18481 cggcgatcct tccgcagtcc cgggccggga ggcggcatcc gacgcgcggc aatccggggg
    18541 cgggtggtgg ccgccgcccc gggtgcggcc acttggcggc cgtccgcaag aatcctctcc
    18601 cgaccaatcc gggtgccgcc cggcgccgaa tcactcgtga ccacgtcacg tccggaggtg
    18661 tccatgcccg tcgcagcccg cggcgaccga tcccccgcac cgcataccgg tgccctggaa
    18721 tccctgctca cccgcgtctc ccgcggcgac cagtacgcgt tcgagcagct ctacacggcg
    18781 gtggccggct ccgtactggg cctggtgcgc cgggtggtac gggatccggc gcagtccgag
    18841 gaggtcgccc aggaggtgct gatcgaggtg tggcggtccg cggcccgctt cgacgcacgg
    18901 cagggcagcg ccatggcctg gatcatgaca ctggcgcacc gccgcgcggt ggaccgggtg
    18961 cgctccgtcc aggcggcggc cgaccgcgac caccgggccg gcatgggtgc ctacaccgcg
    19021 cccttcgacg aggtcagcga gcaggtcgag cggcggctgg agcgggagca ggtgcgccgc
    19081 tgcctccagc aactcaccga tctgcagcgg gagtcggtga cgctcgccta ttaccgcggc
    19141 tacacctacc gggagaccgc cgatctgttg ggcgccgcgc tgggcacggt caagacacga
    19201 ctgcgggacg gactcatccg gctccgcgac tgcctggggg tgtcggcatg agcaccgtcg
    19261 atctgcacac actgaccggc gcctacgcac tgggcgcgct gtccgagcag gagtccgccg
    19321 agttcacccg ccatctggcg cagtgcccgg cctgctacca ggaagtgcgc gaactccagg
    19381 aaaccgcggc ccggctcgcg ctggccgtgg ccgaggtgcc cccggccgga ctgcgcaccc
    19441 gggtgatggc cgccctgccc gaggtcaggc agctgccgcc gagggggcgc cacgcgaccg
    19501 tggtcccact gcgccgcggt atgcggcacc ggctgccgta cctcgcggcc gccgcctgtc
    19561 tggtcgtcgc cgcgctcgcc ggcgggctgg ccgtccaagc gcagaccgag gccgacgagc
    19621 agcgggaccg cagcgtccgc gccgagcagc aggccgccgc ggtcagcgcc ctgatgaccg
    19681 ccccggacgc caccttccac accaccgcgc tcaagggcgg cggcagcgga acggtcgtcg
    19741 cctcccagcg gaggggccag accgccttcc tctaccacgg cctgccggcg ctgtccggtc
    19801 agcgggtgta cgaactctgg tacagccgca acggcgcgat ggagcccgcc ggactcgtgc
    19861 ggaccggcag cacctccggc gcgatgctgc tgaccggcgg cccccagggc gcggacggcg
    19921 tcggcgtcac ggcggaaccc cagggcggct ccagccggcc caccaccgca ccgctggccg
    19981 tcctccggct gtgacctccg gcccccaccg gatctgaccc cggccgccgg ccccaccacg
    20041 ggccggcggc cggctcgttc cgccccggcg cgcggagccc accgcaccgc cgcccgccgg
    20101 gcattgcggt ccggaacaca tcccgaccaa tccgcgccgc cccgggcgcc gaatccctcg
    20161 atgagcgggc cgccgcaccc cgaacgcggc ccgcgccgag gcgaggaggc agatgaccgt
    20221 ggagcgtcga caaatcgctg tggtgggcgg cggagtggcg ggactcaccg ccgcctacgt
    20281 acttcaacag ggcggctgtg aggtgtcgct gtacgaggcg gaggaccggc tcggcggcca
    20341 cgcccacacc cacgacaggt cctcggcgga cggccgggtc ctacggatcg acaccggctt
    20401 catcgtccac aacgagcgca cctacccgct gctgctgcgg ctgttccgcg aactcggggt
    20461 ggccacccag gactccgaga tgagcatgtc cgtacggtgc gagggctgcg gcctggagta
    20521 cgccggtgcc cgcgggccgg ccggactctt cgcccggccg agcagcgccc tgcgcggccg
    20581 ctatctgcgg atgctgaccg agatccgggc cttccaccgc gccgcgcgca ccacgctcgc
    20641 caccgaccgc ggtgacaccc tgaccctcgg ccggttcctc acccgctgcg gcttctcccg
    20701 gtacttcgtc acccacttcg tcaccccgct ggtctccgcg gtgtggtcct gcgcccccac
    20761 gaccgccatg cagtacccgg ccgtctacct cttccgcttc ctcgcgcacc acggtctgct
    20821 gtcggtcggc ggctcacccc ggtggaagac cgtcaccggc ggctcggtgg agtacgtcag
    20881 ccggatcggc aaacagctcc cggccgtcca caccggcact ccggtccgtg ccgtgcaccg
    20941 cgcacccgac cgcgcccgga tcgtcaccga ggacggcacc gagcggagct tcgacgcggt
    21001 ggtggtggcc gtccacccgg accaggcgct gcggatactc gccgacccca ccgccgacga
    21061 acggcagatc ctgggcgcgt tccgctactc acgcaacccc accgtgctgc acagcgacac
    21121 cgcgctgctg ccccgggccc gcggcgcccg cgcctcgtgg aactacctga tggcctcctg
    21181 caccaccccg gcggacgagg tgcgggtcag ctaccacatg aaccgtctgc aacggctgga
    21241 caccccagag gacttcatcg tcaccctcaa cgccaccgac cgcatcgaca gcgaccgggt
    21301 cctggcgcgg atggtgtacg aacaccccct ctacaccccg gagtcggtcg ccgcccagca
    21361 gcggctgccg cagctgaaca cggcggtcac cgccttcgcc ggggcctacc acggctgggg
    21421 cttccacgag gacggctgcc gctccggcgt ccacgcggcc gcggccctgg gcgtgcgctg
    21481 gtgacccccg gcacgaccgc accggccacc ggccccgcca cccacacccc cgccctctac
    21541 gcgtgcctgg tctcccacgc ccgcacggcg ccgctgcggt actccctgcg ccaccgcacc
    21601 tacctgtggc tgatcgacct cgaccatccg ccgcggctgc ccgccgtgct gcggccgctg
    21661 gcccggttcg atgcccgcga ccacttcggc ggcaccgcac cgtcgatccg ggccggactg
    21721 gaacggttcc tgaccagccg gggcgtacgg ctggacggcg ggcgggtgct gatgctcgcg
    21781 cacgcccgcg tcttgggcca tgtcttcaac ccgctgacgc tgtactggtg ccacgaccgg
    21841 cacagcgtgc ccgtctgcgt cgtcgccgag gtgcacaaca cctacggcga gcgccactgc
    21901 tacctgctgc acaccgacgc acagggccgc gccgaggtcg ccaaggactt ctatgtctcg
    21961 ccgttcttcc cggtcgacgg cgcctaccgg atgcggctgc ccgcaccggc cggccggctc
    22021 gacctgaccg tacagctgcg ccgcggcgcc gcccggccgt tcaccgcgac cgtacgcggc
    22081 acccgacagc ccgcgaccgc cggacggctg ctggccgcgg cgctgcgcca tccctggtcc
    22141 acggccgccg tctccctcgg catccgacgg cacggcatcg ccctgttcct gcgccggctg
    22201 cccatccggc cccgtcccca ccaccgcatc caggaaggca tgaagtgaag acttccgtct
    22261 cggaccgcac cgaatccgcc gccgtcgtcc cggccgccgc tcccacgccg gcccacccga
    22321 gggtggacgc ggccacctgg cccgatgtga tgcgcggccc gcgcggctcg gcggcgcgca
    22381 ccgccgtgac ccggctgctc gtccaacggg cgctggccgc cctgccgttg cggatcgccc
    22441 tcggcgacgc ccccgtcacc ggtgccgagg ggccgctggt gcgggtgcac gacccggagg
    22501 cgttcttccg gcggatcggt accgacgggc tgatcggctt cggcgagtcc tatatggcgg
    22561 gggagtggga ggcggacgac ctggtcggcg cgctgaccgt cctcgccgcc cacctcacct
    22621 cgctggtacc cccgccgctt cagcggctgc gcggcgcctg ggcgcgccgc cgcccgagcg
    22681 cacagcgcaa caccctggag ggcgcccggc agaacatcca ccggcactac gacctgtcga
    22741 acgacctgtt cgcgctcttc ctggacccga ccatgacgta ctcctcggcc gtcttccggc
    22801 agggtcccgc tgtgtggggc gacctggccg acgcccagca ccgcaagatc gaccggctgc
    22861 tggacctggc cggtgtcggc gacggcaccc ggctgctgga aatcggcacc ggctggggcg
    22921 aactggccct gcgcgccgcc gcccggggcg cccgcgtcgt ctcggtgacc ctgtcacagg
    22981 agcagcgcga cctcgccctc gcacgtatcg cgcaggccgg ccacgcggac cgggtctcgg
    23041 tcgagctgtg tgactaccgg caggtgaccg gccgttacga cgccgtggtg agcgtggaga
    23101 tgatcgaggc cgtcggcgag gactactggc ccgtctactt cgacaccctg gaacgcctgc
    23161 tgcgtccggg cggccggatc gccctccagg cgatcaccat gccgcacgca cggatgctcg
    23221 ccacccgcac gacctacacc tggatccaca aatacatctt ccccggcggc ctcatcccct
    23281 ccgccgaggc catcgcgcag cacgcggcag ccgccggcct gcgggtgcgg gagaacgacg
    23341 gctacggcgg ccactacgcc gaaaccctgc ggctgtggcg tgagcgcttc acccaacggg
    23401 ccgccgcggt cggcacattg ggcttcgacc cggtgttccg ccggatgtgg gagttctatc
    23461 tcgcctactc cgaggccgga ttccgcgccg gctacctgga cgtccgccaa ctgctcctca
    23521 cccgggccac cacgaccgca ccggacggag gcccccggtg acgcgggtcg cggaccgtct
    23581 cgccgcactg ctcgccgacc ggttcgcggg gagtctgccg gtgcggctgc gggcctggga
    23641 cggcagcgag accggcccgc cggacgcacc ggtggtgatc ctgcgctcaa gccgggcgct
    23701 gcgccgcctg ctctggcagc ccggtgaact cggactggca caggcctaca tcgc
//
