LOCUS       NZ_CP050976            24511 bp    DNA     linear   CON 06-JUN-2024
DEFINITION  Streptomyces sp. RPA4-5 chromosome.
ACCESSION   NZ_CP050976
VERSION     NZ_CP050976.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RPA4-5
  ORGANISM  Streptomyces sp. RPA4-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9051652)
  AUTHORS   Nicault,M., Bontemps,C., Tidjani,R., Gelhaye,E. and Leblond,P.
  TITLE     Mining the biosynthetic potential for specialized metabolism of a
            Streptomyces soil community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9051652)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72x/76x
            Sequencing Technology :: Oxford Nanopore GridION/Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012273495.1-RS_2024_06_06
            Annotation Date                   :: 06/06/2024 02:35:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,979
            CDSs (total)                      :: 7,887
            Genes (coding)                    :: 7,432
            CDSs (with protein)               :: 7,432
            Genes (RNA)                       :: 92
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 455
            CDSs (without protein)            :: 455
            Pseudo Genes (ambiguous residues) :: 0 of 455
            Pseudo Genes (frameshifted)       :: 276 of 455
            Pseudo Genes (incomplete)         :: 232 of 455
            Pseudo Genes (internal stop)      :: 23 of 455
            Pseudo Genes (multiple problems)  :: 71 of 455
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:36:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8004705
            Orig. end                         :: 8029216
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050976.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24511
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="32"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24511
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24511
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14511](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14511)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            679..1824
                     /locus_tag="HEP86_RS35410"
                     /old_locus_tag="HEP86_35410"
     CDS             679..1824
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040332.3"
                     /locus_tag="HEP86_RS35410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35410"
                     /product="trypco2 family protein"
                     /protein_id="WP_168482684.1"
                     /transl_table=11
                     /translation="MSTPDRKRSGELDRLRAQAEEDFGTYGPQLADRLLTTCQQLRAAG
                     EGEEALLIAQEAVGIHRALVDRYHPVSVGTGLAHALLQLGLCLAELGAAEEAVDVLQEC
                     LAFTDVLAAHVRPPALRLRCNALECLALILGSAGRTAEAVAASHQAITGYRELFEEDPG
                     VAPELARGLHNLATLLAAGAEREQALIPLEESLVIYDQLSIGGNTALAAERSRAQQLHA
                     VLTGGEGETGDVAGEALSAYHLAAEADAYSATSGLAGIPAYVEIHRVEPVDHVAQPHRE
                     QRSMDRNRIDLTEAVQAVRDDLRAATESFDGGDLQFDMGPIELEFTVELERDPRARSGV
                     RTWVVTDAAAGKASAPARHRLTLTLTPRQLAYRSVDVADRM"
     gene            1936..2553
                     /locus_tag="HEP86_RS35415"
                     /old_locus_tag="HEP86_35415"
     CDS             1936..2553
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973084.1"
                     /locus_tag="HEP86_RS35415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35415"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_168482685.1"
                     /transl_table=11
                     /translation="MRLTKYTHSCVRLERPGGGTLVIDPGIWSEARALHGADAILVTHE
                     HADHVDVLRLKGLGAPVYAPKGADFGGLLDVIEVEPDEEFSAAGFQVTAHGGRHARIYG
                     DLPDCANLGYLIDERLYHPGDSLHVPDEPVETLLVPVQASWLRTSEAIDFVRAVKPERA
                     YGIHDAQINERGLHSVNGWLGEEAGGCYSWVPPGALLPCSGR"
     gene            complement(2616..3194)
                     /locus_tag="HEP86_RS35420"
                     /old_locus_tag="HEP86_35420"
     CDS             complement(2616..3194)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601825.1"
                     /locus_tag="HEP86_RS35420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35420"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_168482686.1"
                     /transl_table=11
                     /translation="MQERKPAPVRSDAQRNRERILEVALAELTRSADAPLSAIAKKAGV
                     GQATFYRNFPNREALVLEVYRHEVQQVSATASQLLETHAPDQALREWMDRLAQYAMAKA
                     GLADAMRKTTCAPGALAGLGHGPVTSAVALLLKANEEAGTIRPGVTPDDFVLAISGLWQ
                     IDPQGDWHGRAERLLDLVMDGLRAGAPGA"
     misc_feature    3256..3269
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.24"
                     /tool="antismash"
     gene            3539..4111
                     /locus_tag="HEP86_RS35425"
                     /old_locus_tag="HEP86_35425"
     CDS             3539..4111
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387173.1"
                     /locus_tag="HEP86_RS35425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35425"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_168482687.1"
                     /transl_table=11
                     /translation="MALSTSSVITLNINGEKRTLPVDHRTTLLDALREQLDLTGTKKGC
                     DHGQCGACTVLLDGSRAVSCLQLAVAAEGREITTIEGVADGDRLHPVQQAFLDFDGYQC
                     GYCTPGQICSAIAVIEEHAAGWPSAVTADVRPEAGAPALTAEEIRERMSGNLCRCGAYV
                     SIVQAVAQAAETEARRTGDAAEGELTA"
     misc_feature    3561..3575
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            4108..5100
                     /locus_tag="HEP86_RS35430"
                     /old_locus_tag="HEP86_35430"
     CDS             4108..5100
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027599.1"
                     /locus_tag="HEP86_RS35430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35430"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_168482688.1"
                     /transl_table=11
                     /translation="MREFGYQRVTEVAGAVALLGADPDARFLGGGTNLVDLMKAGVERP
                     ALLVDVRDLPLGRIEPRGDGGLHIGATVTNSELAADPEVRRRYPALAEAVLAGASGQLR
                     NMATVGGNLLQRTRCGYFTDSAKPCNKRAPGSGCPAVEGEHHNHAILGASAHCVAVHPS
                     DMGVALTAFDAVVSYETADGPGELPLAEFYLPVGDTPHRETALPPGALITGITLPPAPV
                     AAASRYRKVRERASYAFAIGSIAAALDVRDGVVREVRLAFGAVASRPWRARTAERVLTG
                     GPADAAAFAAAADAELAAAETLPHNGYKVTLMRNLVVAVLTELAEEAAR"
     gene            5097..7244
                     /locus_tag="HEP86_RS35435"
                     /old_locus_tag="HEP86_35435"
     CDS             5097..7244
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713434.1"
                     /locus_tag="HEP86_RS35435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35435"
                     /product="xanthine dehydrogenase family protein
                     molybdopterin-binding subunit"
                     /protein_id="WP_168482689.1"
                     /transl_table=11
                     /translation="MTATTENLAVTGAVGAAHTRLEGRDKVTGTARFAGEVPFAELAHG
                     WLVLSTIARGRIRSVESAPVLSLPGVLAVLHHENAPRVNGDYQGTLAPPDPILQVFQHD
                     RVPYVGWPVALVVAETPEQAREAAERLVVRYDEEPHDVAFSAGRPGMYTPENSPTMAAE
                     TAKGDLDAELSASAVVVDAEYTTPEEHHSPLEPHAAMARWDSGRLEVVDSNQGSRFVAE
                     ELAQLFSLDPGSVRVRSEHVGGGFGSKATRPHAVLAAMAATVLHRPVRVVLTRRQMFSV
                     VGYRSPTVQRVRLGADVDGRLRAFDHQAESLTSTVFEFVERSANFGRPMYDAAAHHTVN
                     RVVPLDVPTPTWMRAPGEAPGSFALESALDELAEKCGMDPIELRARNEPDVGPVSGLPF
                     SSRRMLACFQEGARRFGWADRDPRPGTRREGRWLLGTGTAAATFPSGVAPSTAAVTAEE
                     DGTFTVRITAADIGTGARTALALIAADALEVAPERIHIQIADSDFGPAMIAGGSMGTRS
                     WAWAITAAVRELREQLALGGGIPPQGITARADTGEAVRALAKKERHSFGAQFAEVAVDV
                     TSGEVRVRRMLGIFAAGRIVNPLTARSQFIGGMTWGLSMALHEEAARDQASGGHVGADL
                     AGYHLAAHADVPPIEADWVDDPDPDDPVGIKGIGEVGIVGAAAAIANAVWHATGVRHRH
                     LPIRPDRVLQAGTAPGGDRDA"
     gene            7237..8394
                     /locus_tag="HEP86_RS35440"
                     /old_locus_tag="HEP86_35440"
     CDS             7237..8394
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382479.1"
                     /locus_tag="HEP86_RS35440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35440"
                     /product="XdhC/CoxI family protein"
                     /protein_id="WP_168482690.1"
                     /transl_table=11
                     /translation="MLDLADALHRWLAEGRDVAVATVVAVDGSAPRGPGAALAVDSRGT
                     VIGSVSGGCVEAAVHDLCAQALQDGQVVLEQFGPDADDAFVVGLTCGGTIEVLVTPIRA
                     DTPGRQVWAAALAAAAGGAAAALALVTRGPAELLGRPLLVHPDGSYEGDLDGAAELDRA
                     VADETHALLDTGRTGTFALSERGARCGSALTLFVASNVPPPRMIIFGAVDFAAALVRTA
                     KLLGYHVTVCDARPVFATRARFPEADDLVVDWPHRYLRRTETDSRTVLCVLTHDAKFDV
                     PLLTVALRLPVAFVGAMGSRRTHEDRNRRLREAGLTARELARLRSPIGLDLGARTPEET
                     ALSIAAEIVAIRQGGTGVPLTGSRTPIHHDVHQRRSDPAGSHAAA"
     gene            8671..9444
                     /locus_tag="HEP86_RS35445"
                     /old_locus_tag="HEP86_35445"
     CDS             8671..9444
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088660.1"
                     /locus_tag="HEP86_RS35445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35445"
                     /product="DUF72 domain-containing protein"
                     /protein_id="WP_168484207.1"
                     /transl_table=11
                     /translation="MTVLVGTSGWQYKDWREVLYPQDRPQRLWLEEYARHFATVESNAA
                     FYRLPEEKTFADWRDRTPDGFVMAVKASRYLTHIKRLREPQEPVGRMMSRAAALGPRLG
                     PVLLQLPPTLKADAGLLDDCLSCFPAGTRVAVEPRHPSWWTAEIRTVLERRGAALCWAD
                     RGSRPVTPLWRTTDWGYLRFHEGRAEPWPRYGGQALTTWARRIADTWPDRADVYTYFNN
                     DPGGAAVRDATVFACAAAAAGRTVSRAPSGRGAAR"
     gene            9523..9807
                     /locus_tag="HEP86_RS35450"
                     /old_locus_tag="HEP86_35450"
     CDS             9523..9807
                     /EC_number="3.6.1.7"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088661.1"
                     /locus_tag="HEP86_RS35450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35450"
                     /product="acylphosphatase"
                     /protein_id="WP_211117494.1"
                     /transl_table=11
                     /translation="MIRRRVVVSGDVHGVFFRDTCRRTADGLGVAGWVRNLPDGTVEAV
                     YEGEPERVQKLVDWAHQGPPLATVDAVSVGEEEPEGLTGFEIRPTPAGF"
     gene            complement(10001..11404)
                     /locus_tag="HEP86_RS35455"
                     /old_locus_tag="HEP86_35455"
     CDS             complement(10001..11404)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="HEP86_RS35455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35455"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_168482691.1"
                     /sec_met_domain="LANC_like (E-value: 1.8e-39, bitscore:
                     134.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPLALCDAASDLAYRVADLLSSPERVAGTAHEAFTALPPELWQ
                     PAWQPASLLMGHPGIALLHTRCARNDARYAAIGHAHLAVAVAATTDAGPAAVGDLLLPA
                     RLHADAHGGYARLLARCAEVHAAYVRARVARLAARQQEHGPGLAADDYDVISGLAGDAR
                     GLLLAADHGDERCAQALRDVLAYLVRMTHPVRSPVAGGSPVPGWWCAPDRYLLPRDREE
                     YPRGDLNVGVAHGICGPLALMALAYRSGHRVPGMADALRRMADWVVSVGYTDHLGMRWP
                     GRVAATEAAGESSHPPQELRPPWEAGARSRPGWCYGTAGIAWSLYLAGRALSDGQLTAV
                     AEDAVGGLVRRPLDAAVSTDPGFCHGRAGVLHTVSRMAVATGRTEWWAMADDLAQELVA
                     EYDPRTPFGFRQVVPPAPGSVSATHRVHHPGLLDGAAGIALVLVDYADARRGGGVDEVN
                     GWDAAFLMG"
     gene            complement(11401..14511)
                     /locus_tag="HEP86_RS35460"
                     /old_locus_tag="HEP86_35460"
     CDS             complement(11401..14511)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="HEP86_RS35460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35460"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_168482692.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4e-171, bitscore:
                     569.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.8e-12,
                     bitscore: 45.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-39, bitscore:
                     134.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALVRAAALPLPSDDPPAPEPRPSVEAPHEEARLRRQIAELATDA
                     RLMTAVSLASASLADEVDRAVAGESLRLKSLRRIARSLTKYRSRMSHRPTPFGLFAGVG
                     LAGFEPTPARELLGDGHTVTRPDAAWLDGVLETLRDLPAVLERSQLTANNLHTVRDGRL
                     VLVDHHDPTGERQLAGSVRHTRVVQHLLTAAARPTPFPLLVEAGRRAFPHAPEGAVEGS
                     ITQLVRGHFLLTDLTPPPDCTAPLDHVRDRLHGVDHPTARELCAVHDELATLDVTPPED
                     RRARLTALSARMRALEPASDVLQTDLSLDVRLTLPPEVAREAAQAATVLWRTSPVHRGN
                     PHLRDYHLAFLERYGTDRAVPVLELLDDARGLGLPRAYRQPEAVPSPESGERDRVLGEL
                     LMDAARRGIREVVLDEETVRALEPAERGPAPLSMEVGAELVAPDWEALCAGDFHLVLAP
                     QAVSPLAGAMFSRFAPVFGPSGTQVQDLALHAEQSAPDDEIPACVAYRPRVARSANVSA
                     VPQWLTHRIPLGVGPAAAETAHDLRLENLAVHADRDGLRLVDGATGRRVRPLSYSMLHP
                     ANGHLPYVARFLLEVGQEGRSFCAPWSWGRWVSAPALPRVRHGRTVLSPARWLPDRALR
                     AAADRGDEEWGEQVGEWRRRRDVPRRVLLTKADHRVAVDLDDPRHLPVLRDEVRRAAGL
                     TLVEQYGGRAERQWFRSAEGPHAAEFVFPVFARSAGRGTAHDTRQTRPAAAPVPPLMDG
                     PDGGRSTRPHLPGGEWLYAKLYVPAARQPEVLARHLGALTDPELLRRAGADRWFFLRYE
                     DPAPHIRLRFHGTPDSLWPVLLPELHSWARELAAAGLLGTVVLDTYEPEVERYGGPAAL
                     GHAERVFHADSESVVALLAMAPDQLDDPSLPAALGILDILTRLGSPDEALDWLSSPSVL
                     AHRGEVPRSRKQEVAALLDAHARPRPPVAADGWGVGWSTRGPALDGLGEVLSAGATDRD
                     RTERIALSLAHMHCNRLLGPRPELERTAQVTAREALARWLGRRRNNR"
     misc_feature    complement(13699..13701)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(13795..14061)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HEP86_RS35460_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.10E-14"
                     /identifier="RREFam001.1"
                     /label="HEP86_RS35460"
                     /locus_tag="HEP86_RS35460"
                     /protein_end="239"
                     /protein_start="150"
                     /score="45.0"
                     /tool="antismash"
                     /translation="TANNLHTVRDGRLVLVDHHDPTGERQLAGSVRHTRVVQHLLTAAA
                     RPTPFPLLVEAGRRAFPHAPEGAVEGSITQLVRGHFLLTDLTPP"
     misc_feature    complement(14164..14166)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14645..14788)
                     /locus_tag="HEP86_RS35465"
                     /old_locus_tag="HEP86_35465"
     CDS             complement(14645..14788)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS35465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_35465"
                     /product="hypothetical protein"
                     /protein_id="WP_168482693.1"
                     /transl_table=11
                     /translation="MENVTINLDEFDLDLDMEIMESATTAVKAQDSKLMTQVCRPTAWP
                     CT"
     misc_feature    complement(14800..14815)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(14920..14933)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    complement(15006..15020)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.55"
                     /tool="antismash"
     gene            complement(15011..16306)
                     /locus_tag="HEP86_RS35470"
                     /old_locus_tag="HEP86_35470"
     CDS             complement(15011..16306)
                     /EC_number="1.3.1.98"
                     /GO_function="GO:0008762 - UDP-N-acetylmuramate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF010478.0"
                     /locus_tag="HEP86_RS35470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35470"
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="WP_348772264.1"
                     /transl_table=11
                     /translation="MRWRVTSRNGPTRCWRRAGRGRCAETWPRAPVGRRAVQGPSAGPR
                     PPLVVRWRRAASGPSPPEGRASPARPFPWHDPSTRNGIQEKQEHMRVTHEAPLAPMTTL
                     GLGGPAAVLFELFDPADFPEFVALADASPGRPVCLGEGSNVVVSDAGCEGAVLRMSTKG
                     VRLTGRTDEGRVLVEVQAGHLLGDLVDTTVAEGLTGMEMLVGIPGTTGATPVQNVGAYG
                     QETADCLVEVTAWDWELGRMVTLDAAACGLGHRTSVFKHSRRWTLLTLVFALRRSELSA
                     PVTYRTVAAALDVPVGSRVPLDEVAQAVLGVRRSKGMVLGCSGTDDRSVGSVFLSPEIS
                     PAQADGLRARNAPVNRFPDGSTRVSASWLIRQAGFELSTPIVTGVRVSSLHYTLVADEG
                     ATAAGFTRAIELVQQEVLRRTGVRLTSELDFL"
     gene            complement(16233..17540)
                     /locus_tag="HEP86_RS35475"
                     /old_locus_tag="HEP86_35475"
     CDS             complement(16233..17540)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601817.1"
                     /locus_tag="HEP86_RS35475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35475"
                     /product="hypothetical protein"
                     /protein_id="WP_168482695.1"
                     /transl_table=11
                     /translation="MNDTSVLATCLARLSWPPERLAREINRRCGSGTISSKAPYNWLKG
                     ACPRRRLPYIIAAILSDHLGEPITVEALWPGHFASAVPPQRRSSAQPRPAAPVRPPATL
                     DPLTASVDWLVADDALPPPSRARGEEIPGVAIEMLTARIQQLRQLDDSGSSGLVLDWAL
                     QDLQWAERLAAKYSYDASTGRQLHRIIAELGQLTAWLTADQGQDELSSARFLAALGAAR
                     AAGDRPLAAYIISCMSYRAGWAGRPEEALRLIRIARKGSAQEDMGIGQALLATREARAH
                     ASLGDEAACQRALDEAAELSRAGRPPAEPLWAYWLTPAVMVADAGRAWLELGCPERAEP
                     YLTRGIDLLQGSQPRNLLLHSASLAEARLARGELDGAAAAATDALALAEHVSSQRAHAR
                     LMALRRRFVRYDSAVARDIAQRADALLAAGRARAVC"
     misc_feature    complement(17520..17522)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17745..17760)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    17765..17781
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.97"
                     /tool="antismash"
     gene            complement(17816..19102)
                     /locus_tag="HEP86_RS35480"
                     /old_locus_tag="HEP86_35480"
     CDS             complement(17816..19102)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088667.1"
                     /locus_tag="HEP86_RS35480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35480"
                     /product="MFS transporter"
                     /protein_id="WP_168482696.1"
                     /transl_table=11
                     /translation="MEPRGRTRWAIGGLLAGGIVVNFLDRTAISVASSSIADEFGLDLQ
                     QLGVVLSAFTWSYCLVQLPAGMLVDLLGVSRLTRIASALWAVAGLLTAVAGGVGPVILA
                     RLLLGVAEGPSMVGASKATAAWFPVSERGMATALFDGATKLANMVAFPVLAFVMSEWGW
                     RAGFLFCAAVSVLFTAVWWWGYRDPSEYRSLGPAEREFILRGGARDTDRGGLRQFRTAL
                     RSGRLWVVACGFACYGYTINIVLTWMPEFLQREFHVRLLQSGLYSMVPWAVATVAELAV
                     GGWLVDRLIRRGRDPWVVRRTVLTCGLALGATIGAAGGAGSPALAVFWMSLSLAGLAIA
                     APVAWGLPGLLAPPGAVGAVSGLMNFLNTAATAGGVLLTGWLAQVSGSFATPFLFAVGV
                     LAVGVALYWRALRPASVRDAVPARELHRV"
     misc_feature    complement(18914..18916)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19319..20326)
                     /locus_tag="HEP86_RS35485"
                     /old_locus_tag="HEP86_35485"
     CDS             complement(19319..20326)
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088668.1"
                     /locus_tag="HEP86_RS35485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35485"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_168482697.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.1e-58, bitscore:
                     195.4, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAPHSAPEPQPVKNVLAVVSPHVGGRAAGSALAGLFPGRARVT
                     VVESADEDLAALREAHLLITGLSPVTAGHLAAAPQLELVQCASHGFDYVDLDAARTRGI
                     PVCNIGSSGAEKQNVAEQTFALMLALAKQLVPAHTALVEADWALPRLQQSLTELSGKTL
                     GIIGLGHIGEEVARRALAFDMTLVYTGPRPAGPETEARLGGARHLDLDALLRTSDYVTL
                     HAPLTDRTRNLLDADRLALLKPTAFVINTARGALIDQDALADALEAGTLAGAGLDVFDP
                     EPPTAALRLLKAPNVVLSPHVAGVTRETLVRIALAAVQNVVGHLEGKPLRDVVS"
     gene            complement(20323..21492)
                     /locus_tag="HEP86_RS35490"
                     /old_locus_tag="HEP86_35490"
     CDS             complement(20323..21492)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389355.1"
                     /locus_tag="HEP86_RS35490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35490"
                     /product="lactate 2-monooxygenase"
                     /protein_id="WP_168482698.1"
                     /transl_table=11
                     /translation="MAKHWADFQYEIYLHGMTGAVPRLPTDLTRLERLAEQRLGPGPVG
                     YVAGSAGTGSTAVANRAALDRRRIVPRMLRDVQERDLSVEVCGRALPAPLALAPVGVLS
                     IMHPDAESAAARAAAAQGVPYILSSASSTPMEEVAEAMGDGERWFQLYWAKDREVTRSF
                     LHRAKAAGYTALFVTLDTPLLAWRPRDLDQAYLPFLHGVGTANYFSDPAFQAGLAKPVH
                     EDPNAAVRHFVGMFADPAKTWPDLAFLRENWDGPIVLKGILHPDDALRAADAGVDGVVV
                     SNHGGRQVAGSVAAADALPRVVEAAAGRLTVLFDSGIRTGDDIFKALALGAKSVLVGRP
                     YAYGLGLDGQAGVEHVLRCLLAEFDLTLALSGHSRPATLTADDLIEESV"
     misc_feature    21464..21482
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.3"
                     /tool="antismash"
     gene            21604..22476
                     /locus_tag="HEP86_RS35495"
                     /old_locus_tag="HEP86_35495"
     CDS             21604..22476
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037653.4"
                     /locus_tag="HEP86_RS35495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35495"
                     /product="hypothetical protein"
                     /protein_id="WP_168482699.1"
                     /transl_table=11
                     /translation="MTEERERIRQQLLAAPRVVTAIVAAVREQVPAYAVLDDGRLDEVR
                     AIAAWALDRLLHLWVTDGALTPADLRRFRGIAAARAADGRPMPAVLRAYRVAATVLTDE
                     IAAARPPLGAPDAFALTRMALTTLDTLSEEMATAYTATSEDLAGDRDRALRLLLDDLIT
                     GRHASIGALTDRAARLGVQLPDSYCLLVAEPTDAAGPAVTREAALGLLVALVGPGGAGT
                     SPVTVRGSRLVLLLPAAAGERAPQALHERGLRGCAISGRAWTGSPSPTVSRPTPWTRRP
                     PTPTSPRGS"
     gene            22590..22769
                     /locus_tag="HEP86_RS35500"
                     /old_locus_tag="HEP86_35500"
     CDS             22590..22769
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024945.4"
                     /locus_tag="HEP86_RS35500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35500"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_168482700.1"
                     /transl_table=11
                     /translation="MAALTTYLDTGSANAAARRLGLHPQSLRYRLRRIADLTHRDPRDP
                     WQRLTLDIARTIGH"
     gene            complement(22845..23306)
                     /locus_tag="HEP86_RS35505"
                     /old_locus_tag="HEP86_35505"
     CDS             complement(22845..23306)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945613.1"
                     /locus_tag="HEP86_RS35505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35505"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_168482701.1"
                     /transl_table=11
                     /translation="MAKRKLTQAEMPVADHAFYGLVWAGTVLTERVDRALSKAHDLPVS
                     WFEVMLWLASSPDPVPASVLGNSTMLSRSQVSRVVDALQSRGLVTRTPSARDARSVEVS
                     LTPEGHQLFEAADDTRRACLAPVFTDLLDRQDLEALSTVWQKLKANKEG"
     misc_feature    23288..23302
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            23401..24258
                     /locus_tag="HEP86_RS35510"
                     /old_locus_tag="HEP86_35510"
     CDS             23401..24258
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (10-183). E-value: 1.5e-16.
                     Score: 52.8. Matches aSDomain:
                     nrpspksdomains_HEP86_RS35510_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268084.1"
                     /locus_tag="HEP86_RS35510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_35510"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_168482702.1"
                     /sec_met_domain="adh_short (E-value: 2.2e-33, bitscore:
                     114.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPSSPSSKVVLITGTSSGIGLAAAVAAAQAGWRVVATLRDTGR
                     SGALRKAAEEAGVELDVRQLDVTDESSVAAAVDGVIADHGRLDAVINNAGAGHLGTLEN
                     ESVADVRAVMEVNFFGVLHVSKAALPHLRATGGRLITVTSVGGIIGQPFNEAYCAAKFA
                     VEGYMESLAPVAARLGVAVSVVEPGAVATEFVNNIGVDLAAEVAAAGPYADALQAYLDR
                     TVAQFLNGAQTPAEAAGAVLEALTADRPAFRLQTSDWAREFTGTKLTDLDGSAVLGLTG
                     GWVG"
     aSDomain        23431..23949
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS35510_PKS_KR.1"
                     /evalue="1.50E-16"
                     /label="HEP86_RS35510_PKS_KR.1"
                     /locus_tag="HEP86_RS35510"
                     /protein_end="183"
                     /protein_start="10"
                     /score="52.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGTSSGIGLAAAVAAAQAGWRVVATLRDTGRSGALRKAAEE
                     AGVELDVRQLDVTDESSVAAAVDGVIADHGRLDAVINNAGAGHLGTLENESVADVRAVM
                     EVNFFGVLHVSKAALPHLRATGGRLITVTSVGGIIGQPFNEAYCAAKFAVEGYMESLAP
                     VAARLGVAVS"
ORIGIN
        1 cgtcgagccc cgattcgatc gagaccacgg ggctggcgta caagacggtc cgccggctgg
       61 tccggagctc cccggccgcg atccggatca tcgtcctgga ctgctgcttc agcggggtcg
      121 ccacgggact gctgagcggt gcgggcgacc tgcgcctcag cgaaccggag gtcgagatcc
      181 cgctcgacga ggagctgccc gacgaccacg ccgacggtgt ctgcgtcatc gcctccagcg
      241 gccccaacca gccgtcccag gactcggacg gggcggatca cacggccttc acggggcatt
      301 tcctcgccac gctgaaggcc gccacacagg ccggtgaagt gcgcgatctg gaagcggtgt
      361 tcgacgggac gaaggcggcg atggtgtccg cggagcttcg gcatgcgccg ttgatcgcct
      421 cgatgggagg ggcccgacgg ctggcgctgg tgaagagcct gacggccgtc gaccccgttc
      481 ctgtcgcggt gccggacgcc gcggtcgtcc gccaaccgac ggcggcggac gaggccgtga
      541 tcgccgcggc gatcgcgccg cacggcgacg ggccggcaaa actcatgagc tggcacaccc
      601 cggtgggcag cgcggacatc ttcgattccg cgctggcact gacgctgctg caacaagcca
      661 tggcaatggg gggtgacgat gagcacgccg gataggaagc ggagcgggga actcgaccgg
      721 ctgcgcgcac aagcggagga agacttcggg acctatggcc cgcagctcgc ggaccggctc
      781 ttgactactt gtcagcaact tcgggccgcc ggtgaaggag aggaagccct cctcatcgcg
      841 caggaggcgg tggggattca ccgggcactc gtcgaccgct accaccccgt ctccgtcggc
      901 accgggctgg cacatgcgct gcttcagctg gggctctgtc tggccgaact cggggcggcc
      961 gaggaggcgg tcgacgtgtt gcaggagtgc ctcgcgttca ccgatgtgct ggcggcgcat
     1021 gtgcggccgc ccgcgctgcg cttgcgctgc aacgcgctcg aatgcctcgc gctgatcctc
     1081 ggctcggcgg gccgcacggc ggaggccgtc gccgcctcgc accaggcgat caccggctac
     1141 cgggagctgt tcgaggaaga cccgggcgtg gcgccggagc tggcccgtgg tctgcacaac
     1201 ctcgccaccc tgctggccgc cggggccgag cgggagcagg ccctgatccc cctggaagag
     1261 tccctggtga tctatgacca gctctccata gggggcaaca cggcgctggc ggcggaacgg
     1321 agccgggccc agcagttgca cgccgtactg acgggaggag agggggagac cggggacgtc
     1381 gcgggcgagg cgctgtccgc ctaccacctg gcggcggagg ccgatgcgta ctcggccacc
     1441 tcgggactgg ccggcatccc ggcgtatgta gagatccatc gtgttgaacc cgtcgaccac
     1501 gtcgcacagc cacacagaga gcagcggagc atggaccgga accggattga cctcaccgaa
     1561 gcggtgcagg ccgtacgcga cgatctgcgc gcggccaccg aatcgttcga cggcggtgac
     1621 ctccagttcg acatgggacc gatcgagctg gaattcaccg tcgagctgga gcgcgacccc
     1681 cgggcacgat cgggtgtgcg cacctgggtc gtcacggacg ccgccgcggg gaaggcgtcg
     1741 gcccccgcca ggcaccggct caccctcaca ctgacgccac gacagctcgc ctatcggagc
     1801 gtcgatgtgg cggacaggat gtaaaaggag gccggtccag gccgacttcg gccgctcggc
     1861 gacgccttcg gagccctgcc gcacggccgc tgcggagggt cgacgcccgt accccggacg
     1921 cgtactctcc gcaagatgcg cctcaccaag tacacccatt cctgtgtccg gttggagcgt
     1981 ccgggaggcg ggacactggt catcgacccc ggtatctgga gcgaggcgcg ggcgctgcac
     2041 ggtgccgacg cgatcctggt gacgcacgaa catgccgacc atgtcgatgt actgcgcctc
     2101 aaggggctcg gtgcgccggt ctacgctccc aagggcgcgg acttcggcgg cctcctggac
     2161 gtcatcgagg tggagccgga cgaggagttc agcgcggccg gcttccaggt cacggcgcac
     2221 ggcggccggc atgcgcggat ctatggggac ctcccggact gcgccaatct cggctacctg
     2281 atcgacgagc gcctctacca ccccggcgac tcgctccatg tgccggacga gccggtggag
     2341 acgctgctcg tgcccgtgca ggcgtcgtgg ctgcgtacgt ccgaggccat cgacttcgtc
     2401 cgggcggtca agccggaacg ggcctacggc atccatgacg cgcagatcaa cgagcggggc
     2461 ctgcacagcg tcaacggctg gctcggcgag gaggcgggcg ggtgttacag ctgggtgccg
     2521 ccgggggcct tgttgccttg ctcggggcgg tgagcgctgg gcgtcggccg gatcgtctgg
     2581 ccccgtacgg cgcccgcttg gccgaaccgt ccccctcagg cacccggagc gcccgcgcgc
     2641 aggccgtcca tgacgaggtc caggaggcgt tcggcgcgcc cgtgccagtc accctgcgga
     2701 tcgatctgcc agaggccgga gatggccagc acgaagtcgt cgggggtcac ccccgggcgg
     2761 atggtgccgg cctcttcgtt cgccttcagt aggagggcga cggctgaggt caccgggccg
     2821 tggcccaggc cggccagcgc gccgggtgcg caggtggtct tgcgcatcgc gtcggccagg
     2881 ccggccttgg ccatggcgta ctgggcgagg cggtccatcc actcccgcag ggcctggtcg
     2941 ggtgcgtgcg tctccagcag ctgggacgcg gtggcggaga cctgctgcac ctcgtggcgg
     3001 tagacctcga ggacgagcgc ctcgcggttg gggaagttgc ggtagaaggt cgcctgcccg
     3061 acgcccgcct tcttcgcgat cgcgctcagc ggggcgtcgg ccgaccgcgt cagttccgcg
     3121 agggccactt cgaggatgcg ttcgcgattc cgctgtgcgt ccgagcgcac cggcgcgggc
     3181 tttctctcct gcactcgtcc tccacccgga atccaccgac ggccgggtct tgctaagcgg
     3241 acaactgtcc ggtagatttt tcgaagctag cggacagctg tccgcttagg tccaccatac
     3301 cgccggatgc ggccgatggg gatggtccgc gaccccgcga ccggctcttc ggccaccacg
     3361 ccgccgcaga agccccagcc gacgccgcca cgtacagcgc ctccctcccg aaccacctgc
     3421 gggtccgtcc cctccgacgc tctcgcaccg cgcgacaagg acagctcgac gtcctggtcg
     3481 gcccgcacgc cttcagggcc ggcccgctgc gcctcaccca tgcgaaagaa ggctgatcat
     3541 ggccctatcg acgtccagcg tcatcacttt gaacatcaac ggcgaaaagc gcacgctgcc
     3601 cgtcgaccac cgcaccaccc tgctcgacgc gctgcgcgag cagctcgatc tcaccggcac
     3661 caaaaagggc tgtgaccacg gccaatgcgg tgcctgcacg gtactgctcg acggaagccg
     3721 ggcggtctcc tgtctccagc tcgcggtcgc cgccgagggg cgggagatca ccaccatcga
     3781 gggtgtggcg gacggcgacc ggctccatcc ggtgcagcag gcctttctcg acttcgacgg
     3841 ctatcagtgc ggctactgca caccggggca gatctgttcg gcaatagccg tgatcgagga
     3901 gcatgcggcg ggctggccga gtgccgtgac cgccgacgta cgccccgaag cgggagcgcc
     3961 cgcgctgacc gccgaggaga tccgggagcg gatgagcggc aatctgtgcc gctgcggtgc
     4021 ctatgtgtcg atcgtgcagg cggtcgcgca ggcggcggag accgaggccc gacggacggg
     4081 cgacgcggcg gagggggagc tgacggcatg agggaattcg gatatcagcg ggtgaccgag
     4141 gtcgccgggg cggtggcgct gctcggggcc gatcctgacg cacgctttct cggcggcggc
     4201 accaacctcg tcgacctgat gaaggccggg gtggagcggc ccgcgctgct cgtcgacgta
     4261 cgtgacctgc ccctgggccg gatcgagccg aggggcgacg gcgggctgca catcggcgcg
     4321 acggtcacca acagcgaact cgccgccgat cccgaggtgc gtcggcgcta cccggcgctg
     4381 gccgaggccg tactggccgg tgcctcgggg cagctgcgca acatggccac ggtcggcggc
     4441 aatctgctcc agcgcacccg ctgcggctac ttcaccgact cggccaagcc gtgcaacaaa
     4501 cgcgcccccg gcagtggttg cccggccgtc gagggtgagc accacaacca cgcgatcctg
     4561 ggcgcctccg cgcattgtgt ggccgtgcac ccctcggaca tgggggtggc gctcaccgcc
     4621 ttcgatgccg tcgtctcgta cgaaaccgcg gacggtccgg gtgagttgcc gctcgcggag
     4681 ttctatctgc cggtgggcga caccccccac cgggagaccg cactgccgcc cggcgcgctg
     4741 atcaccggta tcaccctgcc gccggccccg gtcgccgccg cctcccgcta ccggaaggtg
     4801 cgcgagcgcg cgtcgtacgc gttcgcgatc ggctcgatcg ccgccgccct cgatgtccgg
     4861 gacggtgtcg tccgcgaggt gcgcctcgcc ttcggggcgg tcgcatccag gccgtggcgg
     4921 gcccggacgg ccgagcgggt gctgaccggg ggcccggcgg acgccgcggc gttcgccgcc
     4981 gccgcggacg ccgaactcgc cgccgccgag acgctgcccc acaacggata caaggtgacc
     5041 ctgatgcgca acctcgtcgt ggccgtactg accgaactcg ccgaggaggc cgcccgatga
     5101 ccgccaccac ggaaaacctc gcggtgaccg gggccgtcgg cgcggctcac acccgtctgg
     5161 agggccggga caaggtcacc ggtacggcgc gcttcgcggg cgaggtcccg ttcgccgaac
     5221 tcgcccacgg ctggctggtg ttgtccacca tcgcccgcgg ccggatccgc tccgtggagt
     5281 cggcgcccgt cctgtccctg cccggcgtcc tcgccgtcct gcaccatgag aacgccccgc
     5341 gcgtcaacgg ggactaccag gggacgctcg ctccgcccga cccgatcctt caggtcttcc
     5401 agcacgaccg ggtgccgtat gtcggctggc cggtggcgct ggtcgtcgcg gagacccccg
     5461 agcaggccag ggaagccgcc gaacggctcg tcgtccggta cgacgaggag ccgcacgatg
     5521 tcgccttctc cgccgggcgg cccgggatgt acacaccgga gaattccccc accatggcgg
     5581 cggagacggc gaagggcgac ctggacgccg aactcagcgc gtccgccgtg gtcgtggacg
     5641 cggaatacac cacaccggaa gagcaccaca gcccgctgga accccatgcg gcgatggcgc
     5701 gctgggacag cggccggctg gaggtcgtcg actccaatca gggcagcagg ttcgtggcgg
     5761 aggaactggc gcagctgttc tcgctcgacc cgggctcggt gcgggtgcgg tccgaacacg
     5821 tcggcggtgg cttcggctcc aaggcgaccc gcccgcatgc ggtgctcgcc gcgatggccg
     5881 cgaccgtcct gcaccgcccg gtccgggtcg ttctgacccg ccggcagatg ttctcggtcg
     5941 tcggctatcg cagccccacg gtgcagcggg tccggctcgg cgccgacgtc gacgggcggt
     6001 tgcgtgcctt cgaccaccag gcggagtcgc tcacctcgac cgtgttcgaa ttcgtcgagc
     6061 gcagcgccaa cttcggacgg ccgatgtacg acgccgccgc gcaccacacc gtcaaccgcg
     6121 tcgtcccgct cgatgtcccg acgccgacct ggatgcgggc accgggcgag gcgccgggtt
     6181 cgttcgcgct ggagtccgcg ctcgacgagc tcgccgagaa gtgcggtatg gacccgatcg
     6241 aactgcgcgc acgcaacgaa ccggacgtgg gcccggtctc cggcctgccc ttcagcagcc
     6301 gccggatgct cgcctgcttc caggagggcg cccgcaggtt cggctgggcg gaccgggatc
     6361 cgcgccccgg cacccgccgc gaagggcgct ggctgctcgg gaccggcacc gccgcggcca
     6421 ccttcccctc aggggtcgcg ccgtccacgg ccgccgtgac ggcggaggag gacggcacct
     6481 tcaccgtacg gatcaccgcg gccgacatcg gcaccggagc acggaccgcg ctcgccctga
     6541 tcgccgcgga cgcgctggag gtggctccgg aacggatcca tatacagatc gcggacagcg
     6601 acttcggccc ggcgatgatc gccggcggct cgatgggcac ccgctcctgg gcctgggcga
     6661 tcacggccgc ggtacgcgag ctgcgggagc aactggccct gggcggcggc ataccgccgc
     6721 agggcatcac ggcacgggcg gacaccggcg aagccgtcag ggcgctggcg aagaaggaac
     6781 ggcactcctt cggcgcgcag ttcgccgagg tcgccgtgga cgtcacgagt ggcgaggtgc
     6841 gggtgcggcg gatgctcggc atcttcgccg cgggccgaat cgtcaacccg ctgaccgccc
     6901 gcagccagtt catcggcggt atgacctggg ggctgtccat ggcgctgcac gaggaggcgg
     6961 cccgggacca ggcctcgggc ggccatgtcg gcgccgacct cgcgggctac cacctcgccg
     7021 cgcacgccga tgtcccgccc atcgaggcgg actgggtgga cgacccggac cccgacgacc
     7081 cggtcggcat caagggcatc ggcgaggtcg ggatcgtggg ggccgcggcg gccatcgcca
     7141 acgcggtctg gcatgcgacc ggtgtacgcc accgccatct gccgatccgc cccgaccgcg
     7201 tcctgcaggc cggcaccgca ccaggaggag accgggatgc ttgacctcgc cgacgccttg
     7261 caccgctggc tggcggaggg gcgggacgtc gccgtcgcca cggtcgtggc cgtcgacggc
     7321 agcgcgccgc gcggtccggg cgccgccctc gccgtcgaca gccggggcac ggtcatcggc
     7381 tcggtctccg gcggctgtgt ggaagcggcg gtccacgacc tgtgtgccca ggcgctccag
     7441 gacggccagg tggtgctgga gcagttcggc ccggatgccg acgacgcctt cgtggtaggg
     7501 ctgacctgcg gcggaaccat cgaggtgctg gtcacgccga tccgcgcgga caccccgggc
     7561 cgacaggtgt gggcggccgc gctggcggcc gccgccgggg gagcggcggc ggccctcgcc
     7621 ctcgtgaccc gtggaccggc cgaactcctc ggccgccccc tgctcgtcca ccccgacggc
     7681 tcgtacgaag gcgacctcga cggagctgcc gagctggacc gcgcggtggc cgacgagacc
     7741 cacgccctgc tggacacggg ccgcaccggc accttcgccc tctcggagcg cggcgcgcgc
     7801 tgcgggagcg cgctgaccct gttcgtcgcg tcgaacgtgc cgccgccccg catgatcatc
     7861 ttcggcgccg tcgacttcgc cgcggcgctg gtgcggacgg cgaaactcct cggctaccac
     7921 gtgaccgtgt gcgacgcccg ccccgtcttc gccacccgcg cccgcttccc ggaggccgac
     7981 gacctcgtgg tcgactggcc gcaccgctac ctacggcgca ccgaaaccga cagccgtacg
     8041 gtgctgtgcg tcctcaccca cgacgccaag ttcgatgtcc ccctgctgac ggtggccctg
     8101 cggctgccgg tcgcgttcgt cggcgcgatg ggctcccgtc gcacccacga ggaccgcaac
     8161 cgccggctgc gcgaggccgg cctcaccgca cgcgaactgg cccggctccg ctcaccgatc
     8221 ggcctcgacc tcggggcccg tacccccgag gagaccgccc tgtcgatcgc ggccgagatc
     8281 gtcgcgatac gccagggcgg cacgggggtc cccctgacgg gctcgcggac ccccatccac
     8341 cacgatgtgc accagcggag atcggacccg gccggttcgc atgcggccgc atgacacggc
     8401 cggggccggg cgcccggcgc cagggcgggg ccgcccggac gtcccgcctg gctcgcggcg
     8461 tctgccgcgc acgctgaggg cgccccgagc cccgccctcc ccaggcggac gacgggacat
     8521 tgcggatacg ccccaaggca ggaggcccgc ggtatgcccg gtgactgaca tccggtggct
     8581 gaggtggctg aggcgaccga gatgactgag gtgaccgagg tggctgaggt gactgatatg
     8641 ccgcgccccg gaccgggcag ggatgcggat atgaccgtcc tcgtcggaac ctccggctgg
     8701 cagtacaagg actggcgcga ggtcctttac ccgcaggacc ggccgcagcg actgtggctg
     8761 gaggagtacg cacggcactt cgccaccgtc gagagcaacg ccgccttcta ccggctgccg
     8821 gaggagaaga ccttcgcgga ctggcgggac cggacccccg acggattcgt gatggcggtg
     8881 aaggcaagcc gctatctgac ccacatcaag cggctgcgcg agccgcagga gccggtcggg
     8941 cggatgatgt cgcgggccgc cgccctcggc ccccggctgg ggcccgtcct gctccaactg
     9001 ccgcccacac tcaaggcgga cgccggactg ctggacgact gtctcagctg cttccccgcc
     9061 ggaacccgcg tcgccgtcga gccccgccac ccgtcgtggt ggaccgcgga gatccgtacg
     9121 gtgctggagc ggcggggcgc cgcgctgtgc tgggcggacc gtggctcccg gcccgtgacg
     9181 cccctgtggc ggaccaccga ctggggttat ctgcgcttcc acgaaggccg cgcggaaccc
     9241 tggccgcgct acggcggaca ggcgctcacc acctgggccc ggcggatcgc cgacacctgg
     9301 ccggaccggg ccgacgtcta cacctacttc aacaacgatc cgggcggggc ggccgttcgc
     9361 gacgccaccg tcttcgcctg tgccgccgcg gccgccggcc gcaccgtgag ccgtgcgccg
     9421 tccgggcgtg gcgccgcccg gtgaccgagg gcccgggata tatctgcgct cggaaggccg
     9481 ggccgggcgc acgaggtgac gaggtgaaga gatgagacac ggatgatccg cagacgggtg
     9541 gtggtctccg gagacgtgca cggcgtgttc ttccgcgaca cctgccggcg cacggccgac
     9601 ggcctgggag tggccggctg ggtgcgcaac ctcccggacg ggacggtgga ggccgtgtac
     9661 gagggcgagc ccgagcgcgt acagaagctg gtggactggg cgcaccaggg cccgcccctg
     9721 gccaccgtcg acgcggtgtc cgtaggggag gaggagccgg aggggctgac gggcttcgag
     9781 atccggccga cacccgcagg gttctgaccg ggcggggcac ccgggctgtg ccgtgtcacg
     9841 agccgatggc cggcgcacgc ccggcacgac gagcggcagc gtcagcccat gagggaggcc
     9901 gcgtccgtcg acagccgcag gattctgacc ggccgggcat ccgccccgcc ccgccgcgtc
     9961 accacgggcg accaccgccc ccaccccacg accgcccacg tcaccccatc aaaaacgccg
    10021 cgtcccatcc gttcacctca tccacgccgc ctccccggcg ggcgtcggcg taatcaacca
    10081 ggacgagtgc gatcccggcg gcgccgtcca gcagccctgg atggtgcacc cggtgcgttg
    10141 cggacaccga cccgggggcg ggcggcacaa cctggcggaa cccaaaggga gttcgggggt
    10201 cgtactccgc caccagctcc tgtgcgaggt cgtccgccat agcccaccac tcggtgcgcc
    10261 ccgtggcgac ggccatccgg ctgacggtgt ggaggacgcc cgcacggccg tggcagaagc
    10321 cggggtcggt ggataccgcg gcatcgagcg ggcggcgcac cagaccgccg accgcgtcct
    10381 ccgccacggc cgtcagctga ccgtcactga gcgcccgccc ggccagatac agggaccagg
    10441 cgataccggc tgtcccgtaa caccaccccg gccggctcct cgctcccgcc tcccagggcg
    10501 gccggagttc ctggggcggg tgggaagact ccccggctgc ctccgtagcg gcgacgcggc
    10561 cgggccaccg catgcccagg tggtcggtgt agcccacgct caccacccag tcggccatac
    10621 ggcggagggc gtccgccatc cccggcaccc ggtgtccgga ccggtaggcc agcgccatca
    10681 gcgccagggg cccacaaatc ccgtgcgcga caccgacgtt gaggtcacct ctcgggtact
    10741 cctcgcggtc acgggggagt aggtagcggt cgggggcgca ccaccacccc ggcactgggc
    10801 ttccgcctgc caccggggac cgcacgggat gcgtcatccg gaccagatag gcgaggacgt
    10861 cgcggagcgc ctgcgcgcat cgctcgtcgc cgtggtcggc cgccagcagg aggccgcggg
    10921 cgtcgcccgc caggcccgag atcacgtcgt agtcgtcggc cgccagccca gggccgtgtt
    10981 cctgttgccg ggccgccaac cgggcgacac gggcccggac gtatgcggcg tgtacctcgg
    11041 cgcagcgcgc cagcagccgg gcatagccgc cgtgcgcgtc ggcgtgcagc cgtgcgggca
    11101 gcagcagatc accgacagcg gccggaccgg cgtcggtggt cgccgcgacg gccaccgcga
    11161 gatgggcgtg cccgattgcc gcataccggg cgtcgttccg ggcgcatctg gtgtgcagca
    11221 gcgcgatgcc cgggtggccc atcagcagcg acgcgggctg ccaggcgggt tgccacagtt
    11281 ccggcggcag tgcggtgaac gcctcgtgtg ccgtaccggc cacccgctcc ggtgagctca
    11341 gcagatcggc gacgcggtac gcgaggtcgg acgccgcgtc gcacagcgcg aggggtgcgg
    11401 tcatcggttg ttccgccgcc gtccgagcca ccgtgccagc gcctcacggg ccgtcacctg
    11461 cgccgtccgt tccagttcgg gccgtgggcc gagcagccgg ttgcagtgca tatgggccag
    11521 gctcagggcg atccgttccg tccggtcgcg gtccgtcgca ccggccgaca acacctcacc
    11581 cagaccgtcc agcgccgggc cgcgggtgct ccaccccacg ccccagccgt ccgccgcgac
    11641 cggcggccgg ggccgggcgt gcgcgtccag cagcgcggcg acctcctgct tccgggaccg
    11701 cgggacctct ccacggtgcg ccagcaccga cgggctactg agccagtcga gcgcctcgtc
    11761 cggggagccg aggcgggtga ggatgtcgag gatgcccagc gcggccggca gcgagggatc
    11821 gtccagctgg tcgggggcca tggccagcag cgcgacgacg gactcgctgt cggcgtggaa
    11881 gacgcgctcg gcgtgcccca gggcggccgg tccgccgtac cgctcgacct cgggttcgta
    11941 ggtgtccagg accaccgtcc cgaggagccc cgccgccgcc agctcccgtg cccaggagtg
    12001 gagttcgggc agcagcaccg gccacaggga atccggcgtg ccgtggaagc gcagccggat
    12061 gtgcggcgcc gggtcctcgt aacggaggaa gaaccagcgg tcggcgcccg ccctgcgcag
    12121 cagctcgggg tcggtcagcg cgccgaggtg acgggccagc acctccggct ggcgggccgc
    12181 gggcacatag agcttggcgt agagccactc gccgccgggc agatggggac gcgtgctccg
    12241 gccgccgtcc gggccgtcca tcaggggcgg taccggcgcc gcggctggcc gggtctgccg
    12301 ggtgtcgtgc gcggtgcccc ggcccgcgga ccgggcgaag acgggaaaga cgaactcggc
    12361 ggcatggggg ccctcggcac tccggaacca ctgccgttcc gcccggcccc cgtactgctc
    12421 caccagcgtc agaccggccg ctcgccgcac ctcgtcccgc aagaccggga gatggcgcgg
    12481 atcgtcgaga tcgaccgcga cgcggtggtc ggccttggtg agcagcaccc gccggggcac
    12541 atcccggcgc cgccgccact ccccgacctg ctcaccccac tcctcgtccc cacggtcggc
    12601 cgccgcgcgc agggcacggt ccggcagcca gcgcgccggg gagagcacgg tccggccgtg
    12661 ccgcacccgc ggcagcgcgg gagccgagac ccagcgtccc cagctccacg gtgcgcagaa
    12721 ggaccggcct tcctgcccga cctccagcag gaaccgtgcc acgtacggaa gatgaccgtt
    12781 ggccggatgg agcatcgagt acgagagcgg gcgcacccgg cggccggtcg cgccgtcgac
    12841 gagccggagg ccgtccctgt ccgcgtggac cgcgaggttc tccaggcgca gatcgtgcgc
    12901 cgtctccgcg gcggcagggc cgacccccag ggggatgcga tgggtcagcc actgcggaac
    12961 ggcggagaca ttggcggagc gtgccaccct gggccggtag gcgacacagg ccggaatctc
    13021 gtcgtccggt gcgctctgct cggcgtgcag cgccagatcc tgaacctgcg tgcccgaggg
    13081 gccgaatacc ggcgcgaatc ggctgaacat cgcccccgcc agcggcgaca ccgcctgcgg
    13141 cgcgagcacc agatgaaagt ccccggcgca cagcgcctcc cagtccggag ccaccagctc
    13201 ggcgcccacc tccatgctca gcggggcggg cccgcgctcc gccggttcca gggcgcgcac
    13261 ggtctcctcg tccagcacca cttcccgtat gccacggcgc gccgcgtcca tcagcagctc
    13321 gccgaggacc cggtcgcgct ccccggactc gggggagggc acggcttcgg gctgccgata
    13381 ggcgcggggg agccccaacc cccgggcgtc gtcgagcagt tccaggaccg gcaccgcgcg
    13441 gtcggtgccg taccgttcga ggaaggccag gtggtagtcg cgcaggtgtg gattgccgcg
    13501 gtggacgggg gaggtccgcc acagcaccgt cgcggcctgt gccgcttccc gggccacctc
    13561 gggcggcagg gtcagtcgta cgtccaggga caggtcggtc tggaggacgt cggaagccgg
    13621 ctccagcgcc cgcatccgtg cggagagcgc ggtcagccgg gcccgccggt cctccggagg
    13681 tgtgacatcc agggtcgcta actcatcgtg taccgcgcac agttcacggg cagtcggatg
    13741 gtcgaccccg tgcagccggt cgcgtacgtg gtcgaggggg gcggtgcagt cgggtggcgg
    13801 cgtcaggtcg gtcagcagga agtggccgcg cacgagctgg gtgatgctgc cctcgaccgc
    13861 gccttcgggc gcgtggggga acgctcgccg gcccgcttcc accagcagag gaaacggcgt
    13921 gggccgcgcc gcggccgtca ataggtgctg gaccacacgg gtgtggcgca ccgaccccgc
    13981 caactgccgt tcgccggtgg ggtcgtggtg gtcgacgagc accagccgtc cgtcccgtac
    14041 ggtgtgcagg ttgttggccg tgagctgcga gcgctccagt acggcgggga ggtcgcgcag
    14101 cgtctccagc acgccgtcca gccaggccgc gtccggccgg gtcacggtgt gcccgtctcc
    14161 gagtaattcc cgtgcgggtg tgggttcgaa tccggcgagg ccgaccccgg cgaacaggcc
    14221 gaacggggtg gggcggtggg acatccgtga gcggtatttc gtcagcgacc tcgcgatacg
    14281 gcgcagcgac ttgagccgga gcgattcccc ggcgacggcg cggtccacct cgtccgcgag
    14341 gctcgcgctg gccaggctca ccgccgtcat cagccgtgcg tcggtggcca gttccgcgat
    14401 ctgacggcgc agtcgggctt cctcgtgcgg ggcctcgacg gacggccggg gctcgggggc
    14461 cgggggatcg tccgagggca gtgggagggc tgcggcccgt accagagcca ctttcccgca
    14521 ctcgaatcgc acatcacccg taccgctcac gcctgtcccc gccccgttcc cctgacaccg
    14581 cttgacccga cgatggtgtg gggtgccgtg ggagcgatgt cccgcggcac cccacaccgg
    14641 tgtgtcaggt gcagggccaa gcggtgggcc ggcagacctg cgtcatgagc ttcgagtcct
    14701 gcgccttcac ggcggtcgtg gccgactcca tgatctccat gtccaggtcg aggtcgaatt
    14761 cgtccaggtt gatggtgacg ttctccatgg tcccctccag ggaaagaaaa tttaattccg
    14821 gagtatttcc ggttgttgcg gagatatttc gcaaccgccg gggtatttca tacgaggtcg
    14881 cgatcttcgt caagagcgtt taaagcccgc ccggcgaggg caacgcccgt gccctgaacc
    14941 ggagttgacc tgttgaagcg cgccggctgc acgcctccac tgcggccccc gcgcggccct
    15001 cggacaaggt tcagagaaag tcgagttcgg aggtgagccg gacccccgtg cggcgcagca
    15061 cttcctgctg tacgagctcg atcgcccggg tgaaaccggc ggcggtcgcc ccctcgtcgg
    15121 cgaccagggt gtaatgcagc gaggaaacgc gcacgcccgt gacgatcggg gtgctcagct
    15181 cgaaaccggc ctgccggatg agccagctcg cactcacccg cgtcgagccg tcggggaagc
    15241 ggttcacggg ggcgttgcgc gcccgcaggc cgtcggcctg ggcgggggag atctcggggc
    15301 tgaggaacac actgccgacc gatctgtcgt cggtgccact acagcccagc accattccct
    15361 tgctccgccg gaccccgagc accgcctggg ccacctcgtc cagcggcacc cggctcccga
    15421 ccgggacatc gagcgcggcg gccaccgtcc gatacgtcac cggcgcgctc agctcggacc
    15481 ggcgcagcgc gaagaccagc gtcagcaggg tccaccggcg ggagtgtttg aagacgctgg
    15541 tgcggtggcc cagcccgcag gccgcggcgt ccagggtgac catccggccc agctcccagt
    15601 cccacgcggt cacttccacc aggcagtcgg cggtctcctg gccgtaggcg ccgacattct
    15661 ggaccggggt ggcgccggtg gtcccgggga tgcccaccag catctccatg cccgtgaggc
    15721 cctcggcgac ggtggtgtcg accaggtcgc cgaggaggtg tccggcctgc acctcgacca
    15781 gcacccgccc ctcgtcggtg cggccggtca gccgcacgcc cttggtgctc atccgcagca
    15841 ccgcgccctc gcagccggca tcgctgacca cgacattgct tccttcgccg agacagaccg
    15901 gccggcccgg ggaggcgtcg gccagcgcga cgaactcggg gaagtccgcg gggtcgaaca
    15961 gctcgaagag gaccgccgcc ggtcctccga gacccagcgt ggtcatcggg gcgagcggtg
    16021 cctcgtgagt gactcgcata tgttcctgtt tctcctggat gccgttccgt gtcgaggggt
    16081 cgtgccatgg gaaggggcgc gcgggtgagg cccggccctc agggggcgac gggccggacg
    16141 ccgcccggcg ccaccgcacg acgagcgggg gccggggccc tgctgacggt ccctgaacgg
    16201 cacggcggcc gacgggtgct cgtggccacg tctcagcaca ccgcccgcgc ccggcccgcc
    16261 gccagcagcg cgtcggcccg ttgcgcgatg tcacgcgcca ccgcactgtc gtaccgcacg
    16321 aaccgccgcc gcagcgccat cagccgcgcg tgggcgcgct gcgagctgac gtgctcggcc
    16381 agcgccagcg cgtccgtggc agccgccgca gcgccgtcga gttcgccgcg cgccagccgc
    16441 gcctcggcca gtgaggcact gtgcagcagc aggttgcggg gctggctgcc ctggagcagg
    16501 tcgatcccgc gcgtgagata cggctccgcc cgctcggggc accccaactc cagccaggcc
    16561 cggccggcgt cggccaccat gaccgcgggg gtgagccagt acgcccagag cggctcggcc
    16621 gggggccggc ccgcccggct gagctcggcc gcctcgtcca gagcccgctg acaggccgcc
    16681 tcgtcaccga gactggcatg ggcccgggcc tcgcgggtgg ccagcagcgc ctggccgatg
    16741 cccatgtcct cctgcgccga ccccttgcgg gcgatccgga tcagccgcag cgcctcctcc
    16801 ggccggccgg cccagccggc ccggtagctc atacaggaga tgatgtacgc ggcgagcggc
    16861 cggtcaccgg cggcccgtgc ggcgcccagg gcggccagga agcgggcgct gctcagctcg
    16921 tcctggccct gatccgccgt cagccaggca gtgagctggc cgagttcggc gatgatgcgg
    16981 tgcagttgcc gtccggtcga cgcgtcgtag gagtacttgg cggccagcct ttccgcccac
    17041 tggaggtcct ggagcgccca gtccagtacg agcccgctgc tgccgctgtc gtccagctga
    17101 cgcagctgct ggatcctggc ggtcagcatc tcgatcgcga ccccgggaat ctcctcgccg
    17161 cgcgcccgcg agggcggcgg cagtgcgtcg tcggccacca gccagtccac cgacgcggtg
    17221 agcggatcga gggtggcagg cggccgcaca ggcgccgcgg ggcgcggctg ggcggagctt
    17281 cgccgctgcg gcgggaccgc ggacgcgaag tgcccgggcc acagcgcctc gaccgtgatc
    17341 ggctcaccga ggtggtcgga caggatcgcc gcgatgatgt acggcagccg gcgccggggg
    17401 caggcgccct tcagccagtt gtacggagcc ttgctgctga tggtgccgct gccgcaccgc
    17461 cggttgatct cacgggccag ccgctccggt ggccaggaca agcgcgccag gcaggtcgct
    17521 aatacagagg tgtcgttcat cggcggagca cctcggccgc ggcggcgttc gatgccgggg
    17581 gaggggtggc cgggactgtc ggctccggcg actgccgggg gtgctccgga gtcatgtctg
    17641 accggcgtgg aatcgggccg acgatctgca tagccgcttt ccacgccccc ctgccgacaa
    17701 ctgcccagcc atagtaggga ttcccggggg tgggaggccg aatctgtgat gaccgacaca
    17761 gctactgcac accatgtgca agtacaggat taaagcatcg ggcgacgatg cggcctcaga
    17821 ccctgtgcag ctcccgggcc gggaccgcgt cccgtaccga tgccgggcgc agcgccctcc
    17881 agtacagcgc gaccccgacc gccagcacgc cgaccgcgaa caggaagggc gtggcgaacg
    17941 acccgctcac ctgcgccagc cagccggtca gcagcacacc gcccgcggtg gccgccgtat
    18001 tgaggaagtt catcagcccg ctgaccgcac ccaccgcgcc cggcggggcg agcaggccgg
    18061 gcagccccca ggcgaccggc gcggcgatgg ccagccccgc cagggagagg gacatccaga
    18121 agaccgcgag ggcgggggat ccggcgccgc ccgcggcgcc gatcgtggca ccgagcgcca
    18181 gtccgcaggt cagcaccgtt ctgcggacca cccacgggtc gcggccccgg cggatcagcc
    18241 ggtccaccag ccagccgccc acggcgagtt cggccaccgt cgccaccgcc cacgggacca
    18301 tcgagtagag gccggactgc aacagccgca catggaactc ccgctgaagg aactccggca
    18361 tccaggtcag cacgatattg atggtgtagc cgtaacaggc gaaaccgcag gccacgaccc
    18421 agagccggcc ggaacgcagc gccgtgcgga actgccgcag cccgccccgg tcggtgtccc
    18481 gcgccccgcc ccggaggatg aactcccgct cggccggccc cagggagcgg tactcggacg
    18541 ggtcccggta gccccaccac cacacggcgg tgaacagcac actgaccgcg gcgcagaaca
    18601 ggaacccggc ccgccagccc cactcgctca tcacgaacgc cagcaccggg aacgccacca
    18661 tgttggccag cttggtggca ccgtcgaaca gggccgtcgc catcccgcgc tcactgaccg
    18721 ggaaccacgc cgcggtcgcc ttggaggcgc ccaccatcga cggaccctcg gccaccccga
    18781 gcagcagccg cgccaggatg accggcccga ccccgccggc caccgcggtc agcaggcccg
    18841 cgacggccca cagcgcggag gcgatccggg tgagccgcga gacccccagg aggtccacga
    18901 gcatgccggc gggtaactgc accaggcagt acgaccaggt gaacgccgag agcaccaccc
    18961 cgagttgctg gaggtccagc ccgaattcgt cggcgatcga ggaactcgcc accgatatcg
    19021 ccgtacggtc aaggaagttg acgacgatac cgccggcgag cagtccgccg atcgcccaac
    19081 gggtacgtcc acggggttcc acgcgcgtgc gccagccttt cctggtgggg cctcggagcc
    19141 gatgccgggc ggacgctact ccagtcgccg ggggcccggc cgtcgggggt gtcgagaaat
    19201 ggcggtggcg cgccaggaac gcgccaccgc accgcccgcc cctgtgcacg aacccgctga
    19261 ccggaacccc gaactatggc cgaaattcag gagggagcgc gcacccggcg ccccgccgtc
    19321 aggacacgac gtcccgcagc ggcttgccct ccagatggcc gacgacgttc tgcaccgcgg
    19381 ccagggcgat acggaccagg gtctcccggg tgacgcccgc gacgtgcggg gagagcacca
    19441 cattcggggc cttgagcagg cgcagcgccg ccgtgggcgg ttcggggtcg aagacgtcga
    19501 gcccggcccc ggcgagggtg cccgcctcca gggcgtcggc gagggcgtcc tggtcgatga
    19561 gggcgccgcg tgcggtgttg atgacgaagg cggtcggctt gaggagggcg agccggtcgg
    19621 cgtcgaggag gttgcgggtc cggtcggtga gtggagcgtg cagggtgacg tagtcggagg
    19681 tgcggagcag tgcgtcgagg tccaggtgcc gggcgccgcc gagccgggcc tcggtctccg
    19741 gtccggcggg ccgcggcccc gtatagacga gggtcatgtc gaacgcgagg gcgcggcggg
    19801 ccacttcctc gccgatgtgg ccgaggccga tgatgccgag ggtctttccg gagagttcgg
    19861 tcagcgactg ctgaaggcgc ggcagcgccc agtcggcctc gaccagggcc gtgtgggccg
    19921 ggaccagctg cttggcgagg gcgagcatga gggcgaaggt ctgctccgcc acattctgct
    19981 tctccgcgcc gctggagccg atgttgcaga ccgggatgcc ccgcgtgcgg gccgcgtcca
    20041 ggtcgacgta gtcgaagccg tggctggcgc actggacgag ctccagctgc ggtgcggcgg
    20101 cgagatggcc cgcggtgacc ggactcagcc cggtgatcag cagatgcgcc tcgcgcagcg
    20161 ccgccaggtc ctcgtcggcc gactcgacga cggtgacccg ggcccggccg gggaacagac
    20221 cggccagcgc ggaaccggcg gcccggccgc cgacatgcgg tgagacaacg gcgagaacgt
    20281 tcttcacggg ctgcggctcc ggggccgagt gcggcgcgct ggtcatacgg attcctcgat
    20341 caggtcgtcg gcggtcaggg tggcggggcg ggagtgcccg gacagggcga gggtgaggtc
    20401 gaactcggcg agcagacagc gcaggacatg ctccacgccg gcctgtccgt caaggccgag
    20461 accgtaggcg taaggccgcc ccaccagcac ggacttggcg cccagggcga gcgccttgaa
    20521 gatgtcgtcg ccggtgcgga taccgctgtc gaagaggacg gtgagccgcc cggcggccgc
    20581 ctcgacgacc cggggcagtg cgtcggcggc ggcgacggag cccgccacct ggcggccgcc
    20641 gtggttggag acgaccaccc cgtccacccc ggcgtcggcg gcccgcagcg cgtcatccgg
    20701 gtgcaggatg cccttcagca cgatcgggcc gtcccagttc tcccgcagga acgccaggtc
    20761 gggccaggtt ttggcggggt cggcgaacat ccccacgaag tgccggaccg ccgcgttggg
    20821 atcctcgtgc accggcttgg cgagccctgc ctggaacgcg gggtcgctga agtagttggc
    20881 ggtgcccaca ccgtgcagga acggcagata cgcctggtcg agatcgcgcg gccgccaggc
    20941 gaggagcggg gtgtcgagcg tgacgaacag cgcggtgtag cccgccgcct tcgcccggtg
    21001 cagaaagctc ctggtgacct cgcggtcctt cgcccagtac agctggaacc accgctcccc
    21061 gtcgcccatc gcctcggcga cctcctccat gggggtgctg gaggcggagg agaggatgta
    21121 cggcacgccc tgcgccgcgg cggcccgcgc ggcggcggac tcggcgtccg ggtgcatgat
    21181 cgacagcacc ccgaccggcg cgagcgcgag cggcgcgggc agcgcgcggc cgcacacctc
    21241 cacggacaga tcgcgttcct gcacatcgcg gagcatccgc gggacgatcc gccggcggtc
    21301 cagtgccgcc cggttggcga cggcggtgct gccggtgccc gcgctgcccg ccacataacc
    21361 gaccgggccg ggcccgagcc gctgctcggc gagccgctcc agccgggtca gatccgtcgg
    21421 cagccgcggc acggcgcccg tcatgccgtg aaggtagatc tcgtactgga agtccgccca
    21481 gtgcttcgcc atccgtacgt cccgcctctc gtcgctgaga ctgcgtgctc ccggagatcc
    21541 tggcgacagt gacaagtccc gtccaccgcg ctgcgcacaa cacgcgggtg gaatcatcac
    21601 cctgtgacag aggaacggga gcgcatccgg cagcagctgc tcgccgcccc gcgggtcgtc
    21661 acggcgatcg tcgccgcggt gcgcgagcag gtaccggcct acgcggtgct cgacgacggc
    21721 cggctcgacg aggtccgtgc catcgccgcc tgggcgctgg accggctgct gcatctctgg
    21781 gtcaccgacg gcgcgctcac ccccgccgat ctccgccggt tccgcggcat cgcggcggca
    21841 cgggccgcgg acggccgccc gatgccggcg gtcctgcggg cctaccgggt cgcggcgacg
    21901 gtcctgacgg acgagatcgc ggccgcccgg cccccactgg gcgcaccgga cgccttcgcg
    21961 ctcacccgca tggcactgac caccctcgac acactctccg aagagatggc cacggcgtac
    22021 accgccacca gcgaggacct cgccggggac cgcgaccggg cgctgcggct gctcctcgac
    22081 gacctgatca ccggtcggca tgcctccatc ggggccctga ccgaccgggc cgcccggctg
    22141 ggcgtccaac tcccggattc gtactgcctg ttggtggcgg agcccacgga cgcggccggc
    22201 cccgccgtga cccgggaagc cgccctcgga ctcctcgtcg ccctcgtcgg ccccggcggc
    22261 gcgggcacct cgccggtgac ggtccgcggc tcccgcctcg tcctgctgct gcccgccgcg
    22321 gccggcgagc gggcaccgca ggccctgcac gagcggggcc tgcgcggctg tgcgatctcg
    22381 gggagagcct ggaccggatc gccgtcgcct accgtctcgc ggccgacgcc ctggacacgg
    22441 cgcccgccca cgcccaccag cccacgcggg tcctgaccga cggcgacgcc caggtcctgg
    22501 ccctcctcgg cggccgcccc accgccccgc ccgaacacct cagccgcctg atcctcggcc
    22561 ccctcaccca gcccggccgc cagcacctca tggcggcgct caccacctac ctcgacaccg
    22621 gctccgcgaa cgccgccgcc cgacgcctcg gcctgcaccc ccagtcactc cgctaccgcc
    22681 tgcgccgcat cgccgacctc acccaccgcg acccacgcga cccctggcag cgcctcaccc
    22741 tggacatcgc gcggacgatc ggccactgag gagggcggag gcgcgggggc tctgtcggcg
    22801 gtcgggactg ctcgaagccg ccaaccggcc ccgaattccc cgtatcagcc ctccttgttg
    22861 gccttgagct tctgccacac cgtgctcagt gcttcgaggt cctgccggtc gaggaggtcg
    22921 gtgaagaccg gggccaggca ggcgcgccgg gtgtcgtcgg ccgcttcgaa gagctgatgg
    22981 ccctcggggg tgagggagac ctcgacggag cgggcgtcgc gcgccgacgg cgtacgggtg
    23041 accaggccgc ggctctggag cgcgtcgacg acgcgggaga cctggctgcg gctgagcatg
    23101 gtgctgttgc cgagcaccga ggccgggacc gggtccgggc tggaggcgag ccagagcatc
    23161 acctcgaacc aggagaccgg caggtcatgg gccttgctca gggcgcggtc gacgcgttcg
    23221 gtgagcacgg ttccggccca gaccagtccg tagaaggcgt gatcggccac gggcatctcg
    23281 gcctgggtga gcttcctttt cgccatgcgg caaggttacc ggttgcgtgt gcgcacacat
    23341 aatgcttatg gtgtgtgtac acgcacttaa acaagcttcg tacgccccga aaggttcgcc
    23401 atgtcttccc cctcttcccc ctcgtccaag gttgttctga tcaccggcac gtcctccggc
    23461 atcgggctgg ccgccgcggt cgccgcggcg caggccggct ggcgggtggt ggcgacgctg
    23521 cgcgacaccg gccgctccgg tgcgctgcgc aaggcggccg aggaagcggg cgtggagctc
    23581 gatgtccggc agctggacgt caccgacgag agttccgtcg ccgccgcggt cgacggcgtg
    23641 atcgccgatc acgggcgcct cgacgccgtg atcaacaacg cgggtgccgg acacctcggc
    23701 accctcgaaa acgagagcgt ggccgatgtg cgcgcggtga tggaggtgaa cttcttcggc
    23761 gtgctccatg tctcgaaggc ggcgctgccg catctgcggg ccaccggtgg ccgtctgatc
    23821 accgtcacca gcgtcggcgg aatcatcggg cagcccttca acgaggcgta ctgcgcggcc
    23881 aagttcgccg tcgagggcta catggagagc ctggcgccgg tggcggcccg gctcggtgtg
    23941 gccgtgtccg tggtcgagcc cggggccgtg gcgaccgagt tcgtcaacaa catcggggtc
    24001 gacctggcgg ccgaggtcgc cgccgcgggc ccgtacgcgg acgccttgca ggcatacctg
    24061 gaccgcaccg tcgcgcagtt cctcaacggc gcgcagactc ccgccgaggc cgccggggcc
    24121 gtactggagg cgctcaccgc ggaccggccc gcgttccgcc tccagacctc ggactgggca
    24181 cgcgagttca ccggcaccaa gctcaccgac ctggacggct cggcggtgct cggtctcacg
    24241 ggtggctggg tcggctgacc cggcaggtgg gggccgcggg cacgccgggt gatacgcggt
    24301 agctacgccc ggtcgcggga gagcgccggg acgcgcagcc ggctcgcact ctcgtcgtcg
    24361 aagtccgcgc agaaggtgcc gaggacgtct tcgagatgtt ccagggagcg gacggtgtag
    24421 aggacgggct ggtagccgga gatgcggtac ggggtggcgg ccgcggcgcg ggggtccagg
    24481 ggacggatcg tccgcccgtc atgggcgccg a
//
