LOCUS       NZ_CP050976            21533 bp    DNA     linear   CON 06-JUN-2024
DEFINITION  Streptomyces sp. RPA4-5 chromosome.
ACCESSION   NZ_CP050976
VERSION     NZ_CP050976.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RPA4-5
  ORGANISM  Streptomyces sp. RPA4-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9051652)
  AUTHORS   Nicault,M., Bontemps,C., Tidjani,R., Gelhaye,E. and Leblond,P.
  TITLE     Mining the biosynthetic potential for specialized metabolism of a
            Streptomyces soil community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9051652)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72x/76x
            Sequencing Technology :: Oxford Nanopore GridION/Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012273495.1-RS_2024_06_06
            Annotation Date                   :: 06/06/2024 02:35:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,979
            CDSs (total)                      :: 7,887
            Genes (coding)                    :: 7,432
            CDSs (with protein)               :: 7,432
            Genes (RNA)                       :: 92
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 455
            CDSs (without protein)            :: 455
            Pseudo Genes (ambiguous residues) :: 0 of 455
            Pseudo Genes (frameshifted)       :: 276 of 455
            Pseudo Genes (incomplete)         :: 232 of 455
            Pseudo Genes (internal stop)      :: 23 of 455
            Pseudo Genes (multiple problems)  :: 71 of 455
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:36:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6080117
            Orig. end                         :: 6101650
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050976.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21533
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="22"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..21533
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21533
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11533](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11533
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     gene            complement(<805..1545)
                     /locus_tag="HEP86_RS27325"
                     /old_locus_tag="HEP86_27325"
                     /pseudo=""
     CDS             complement(<805..1545)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024743.4"
                     /locus_tag="HEP86_RS27325"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27325"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSARSEWSRPMQVAEPRTLEISDPLDALNVRVVGGTVNVVGTSDG
                     SPARVEVSELHGPPLTVSCDHGTLSVAYDDLPWQGFLKFLERKGWNRSAVISVTVPAGT
                     RVEVGVVGAAAVVSGISGRTDVRGVSGDATLVGLTGRVQADTISGNVEVQSVTGDLRFH
                     SVSGDLTVIDGAGGTVRADSVSGDMVMDLDPAQGADIALTTVSGEVAIRLPDPADATVE
                     ANTASGTVSNAFDALRVTGRWGAKK"
     misc_feature    1514..1529
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.14"
                     /tool="antismash"
     gene            1817..2005
                     /locus_tag="HEP86_RS27330"
                     /old_locus_tag="HEP86_27330"
     CDS             1817..2005
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS27330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_27330"
                     /product="hypothetical protein"
                     /protein_id="WP_168481351.1"
                     /transl_table=11
                     /translation="MCGHARHRAEIRHALDAARNHIQGAEHHNKKACIEHDRPYGRAAL
                     NGEYDAQRRLRDAARYS"
     gene            complement(2116..2298)
                     /locus_tag="HEP86_RS27335"
                     /old_locus_tag="HEP86_27335"
     CDS             complement(2116..2298)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603154.1"
                     /locus_tag="HEP86_RS27335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27335"
                     /product="DUF6104 family protein"
                     /protein_id="WP_018087464.1"
                     /transl_table=11
                     /translation="MYFTDRGIEELENRRGEEEVTLAWVADQLRTFVDLNPDFEVPVER
                     LATWLARLDDEDEDE"
     gene            2452..2871
                     /locus_tag="HEP86_RS27340"
                     /old_locus_tag="HEP86_27340"
     CDS             2452..2871
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087463.1"
                     /locus_tag="HEP86_RS27340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27340"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_168481352.1"
                     /transl_table=11
                     /translation="MQDRAQRIELPDGTEVWARVSRLDTPAPDGTDDADGEFEDVGAWD
                     ALGARVEGLREVIGGVAASVRQATERVAPHETSVTFGVELSAKPGKAVALLADGEAKSN
                     LSVTLTWRREDRAPTGDAPHEPHPADRREPDDSSR"
     gene            2871..5111
                     /locus_tag="HEP86_RS27345"
                     /old_locus_tag="HEP86_27345"
     CDS             2871..5111
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603152.1"
                     /locus_tag="HEP86_RS27345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27345"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_168481353.1"
                     /transl_table=11
                     /translation="MSTSEGRAAGRGDRARYTQLLDHAGRTTVALRAAPGGAAARPWGS
                     GVLIAPGWVLTCAHVLAASDGRRRETGPDGVFGVTFDGRVVPARLAYDLSLPDPAAGPA
                     AARADLALVQLLDLETDHPCAWLSDQPATLLEDAYIFRGHDASGAVTQGDGDAGTGHRG
                     ERVVREAGGAGDPQDGSPGPEPGGGRGTRGRAEHTAPAGPRAPAPPIDPFIAVRFGARD
                     ARGLQFGSDVRVSPGASGGPLLDCDRGEVVGIVKGRHQQDHVGLAVPVTALRGLGPEHL
                     VAGAEGLGPDPYHALMSLHDRWHWAGQDLGRTAGPTWFDAQHMIMAGRGRLWGVQERLQ
                     ALDLLARLPAPRDPLVVEAAVGEVLERGERPGAWLLRTWRDGHGALYQGSDPYTELRAF
                     VHYLRIVAQLTADEVRDAPGDEAAAVREQAARLAEFVQAKAVVLQPQDRRRIGPVRRRP
                     RSVLVEFEPLFYDEGGQELFNWSVSEGYGQGQWLRVDVQESAGGVPFEQAREQVLRRLG
                     GRLLRADGDAGPNARVRLEVAVPEGRWDTAAGQWEVAASTRRTARLRPVGPGRAVILRD
                     QGRREQVDPAWLRRWQGLAAARELQALRIPPRPGADARSGSAEAIWRLLETAGEGALPA
                     LCHTVADGFGRDAVGVALDTGFPAGLWPAHGHGEERDCDAGCEEFHRGVRELLQGSGGV
                     ARLPELVRQLRAKAAEAAEEGTHWARDLVLLYDDPEDPIPPLFTDRPQMSPR"
     misc_feature    complement(5319..5332)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     gene            5461..6516
                     /locus_tag="HEP86_RS27350"
                     /old_locus_tag="HEP86_27350"
     CDS             5461..6516
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603151.1"
                     /locus_tag="HEP86_RS27350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27350"
                     /product="MoxR family ATPase"
                     /protein_id="WP_168481354.1"
                     /transl_table=11
                     /translation="MSDWLIYRGAGAPHDGIEHLPPPPPWRDFDGGPLVAPPAALDPSS
                     ERRLGVQHREASHHRPGETERELVNAALYLRRPLLVTGAPGSGKSTLAHSVAYELGLGR
                     VLGWPVVSRSTLRDGLYDYDAIGRLQDLQIARAAPAAADDAAAPGPDPTDEPGGGIGRY
                     IRLGPLGTALLPAARPRVLLVDELDKSDIDLPNDLLNVLEEGEFRIPELERLAGSAPEV
                     EVLSDDGTRVTVRDGRVRCRAFPFIVLTSNGERDFPAPLLRRCIHLHIPVPDKERLAAM
                     VRAHFGEGAAERYEAVIDRFLDREPGDVRAVDQLFNAIHLTQRAGWTDEDEEETRRRLT
                     AELMRPLDRTR"
     gene            6522..8021
                     /locus_tag="HEP86_RS40895"
     CDS             6522..8021
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041121.1"
                     /locus_tag="HEP86_RS40895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAV_2336 N-terminal domain-related protein"
                     /protein_id="WP_248001317.1"
                     /transl_table=11
                     /translation="MPPGEPGPGPLDELVARLTAAGLPADARGMADALWLAQWITPGPS
                     RAQSAADAGPTHGDPPDRTDSATFRVGPSASAESAGTGGAAPDGSGTETADGDPAPPVL
                     QEGTRRRVAELLPTRDPGDARFPDPDRQRLGEVAVPIASAFPGLLPLQRALRPIQRYRP
                     PVAPVPRRLDEPATAELSAHAEMIIPVLRGVHRRAAGLRLLMDGSSSMAVWEQMLHDLR
                     QVCERVGAFRDVTVHYLHPHGPDVGVAAAPGPGRPLRPADQLHDPTGHHLTLVVSDCAG
                     PLWRDGRMQRLLYRWAADAPLAVVQPLPQRMWARTLLPAVAGTLVRRQGPYQALGFRPA
                     RRRRRPAGPPGAAEAPRERAVPVLSATPSALGSWARLAAADAGLSLRRGLRRPGRPRRR
                     ASGRTAARVRDGRAGPYGPRVRPAGLTGRPAARRASVGRAARAARHPARPARDAAADRP
                     GRAGGGAAQRPGHATPAGRAAVGGAGRGERPLVRLRARCTR"
     gene            7978..8565
                     /locus_tag="HEP86_RS40900"
     CDS             7978..8565
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS40900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_248001318.1"
                     /transl_table=11
                     /translation="MSGPWYDFVPGVRDELLARLSAGEAALVLKHCSLYVERTFGRSAR
                     NFPAVAVAMLSGSGREPETGQRAVPEPFARVSERVLRRFEPALRPPARRPYATDGPAAE
                     GAALLERYEQDRAGRDLIEAVRLLRAATERLPVAGTDLARALLHAWATWRQPDALEEAE
                     RAARAPNGPPRASPSMTWKVPRRAGRPSAPGR"
     gene            complement(8724..9302)
                     /locus_tag="HEP86_RS40905"
     CDS             complement(8724..9302)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS40905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_248001319.1"
                     /transl_table=11
                     /translation="MLGRIGSGQPEGGGQRGDGGVQRGQLAGAGVYGALGGGRTAQAVR
                     FQGPVVQFMGERTGVFEGGQHGRQARAAVELAGRREVEQGLADQPVGRATTAAQQDRGG
                     VEVVGGADGERLGRARPRGVAAGGPPGLVEQHTAAGRIDLARHLLSAGPLVEERGEGAF
                     RLVERVGVGRPVGGRYGRQGGQAAQDLGA"
     gene            9395..9895
                     /locus_tag="HEP86_RS40910"
     CDS             9395..9895
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS40910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_248001320.1"
                     /transl_table=11
                     /translation="MHVLREALGRVGPQDPDLGSHRLLFGRALRLRYERQPSLADLHEA
                     DWILELAARGADVPDAVAAEAWLEVGDVQLLLDARFDSRERHDRAAACYRRAAAAARRA
                     DSALPAARAHHRRGEVLEVTAGPRSALHAYRESWEQWQRAGEDTGPEAQRTRARMRALE
                     STA"
     gene            10001..10219
                     /locus_tag="HEP86_RS27360"
                     /old_locus_tag="HEP86_27360"
     CDS             10001..10219
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603149.1"
                     /locus_tag="HEP86_RS27360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27360"
                     /product="YxD-tail cyclophane-containing RiPP peptide"
                     /protein_id="WP_168481355.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTPRTEPAVAAPPGPSAERLPDFAGVDVGVLAARTGHAVLGEV
                     AALLLRNWPSAEDAVAYYEDGPEKALH"
     misc_feature    complement(10226..10239)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            10379..11533
                     /locus_tag="HEP86_RS27365"
                     /old_locus_tag="HEP86_27365"
     CDS             10379..11533
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087459.1"
                     /locus_tag="HEP86_RS27365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27365"
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_168481356.1"
                     /sec_met_domain="PTHR43273 (E-value: 2.5e-80, bitscore:
                     269.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 2.4e-132,
                     bitscore: 440.1, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.2e-14, bitscore: 52.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGEKTGPTAVVPFRQFVLKVHSRCNLACTYCYIYAGPDRSWRAR
                     PPTVPAATMRQTALRIAEHARTHRLREVRIDLHGGEPLLTGPGPLLAQAAAVRAALPAG
                     CTAAFGVQTNGTLLTRDMIDTLAAAGFRLGLSLDGGTPGLNRRRIDHAGRPSWPAVSRA
                     VRLLHDRPEVFAGILCTIDITAAPGEVYDSLRALDPPMVDFLLPHANWTSPPPAPLGPA
                     GRTPYGDWLCTAFDLWWDGGPGPRVRVFTEILGLLLGRPSSSEAVGLSPVVALVVDTDG
                     AIEQVDSLKSTYEGAAATGLDVFHHAFDDALAHPGMAARRSGRDGLGAQCRGCALVEVC
                     GGGNYAHRYRADAGGFTNPSVYCADLERLIRHIAARLNATVALN"
     gene            11667..14678
                     /gene="fxsT"
                     /locus_tag="HEP86_RS27370"
                     /old_locus_tag="HEP86_27370"
     CDS             11667..14678
                     /codon_start=1
                     /gene="fxsT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087458.1"
                     /locus_tag="HEP86_RS27370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27370"
                     /product="FxSxx-COOH system tetratricopeptide repeat
                     protein"
                     /protein_id="WP_168481357.1"
                     /transl_table=11
                     /translation="MVDQAHFSGPTGSNEHITISYAGFTRPWAAWISHQLEQQGHGTTM
                     LRWDPQVDTALVAELSGLLEAEGRLLMVLDDWYFRLGPKTQDEWTAALREVVSAHADRF
                     AAVSVATQSLPATASLLRPADLRDLDAHEANRRVLQRLGIAAPGRAVDEDAPGAPRFPN
                     NPPEVWNIPRRNNRFTGRDHVLEALHGKLAGSGAGAGPPLETRIALYGTSGVGKSQIAA
                     EYAHRFGNDYDVVWWISATNRGAAREQLAELATRLGLPVGRELGDRIRAVHEALRVGRP
                     YRRWLLIFDSADDMEQIEDLVPDGRGHVLITTLTRDWSGSGSAQEIEVPPFERVESVAY
                     ARRRAPRLTPMEADLLSEAVQDLPLLLAQTAAWLDANPMSPKEYIELIRRGEPSLVGIR
                     ISSDYPMAFQTSWAITLNTLRERSPAAVELLKLFAFFAPDTIPVPMLARARRGDLPEHL
                     ADLAAEPISWNTALRRLTESTAVRLDYQVSQDADPAVETALMHRLYHRFLRSDMTEDER
                     DLMSACACRVLVTADPQNPADTRYWERYAELIPHLEPAGVLDSPEPAVQQLLLNCVEYL
                     RVRGEYRMGLRLCEQFMSRWRTRLAATQRTMLVLTHQHANMLRRLGRYREAEAVGSAVV
                     DQLAAERAPADADLLRAQDGLAGTLIALGSYEQAYDLFDAVWRAYTELLGPEAPRTLSS
                     RHNLGSVLALLGRYEEALITHREVLSFRERELRARHHLTLNAGTAYARTLRLLGRYRDA
                     TSSQELNARLHLQVMGPHTPQTLRAEHNLALCLRRSGEVTRAATLLADLVERSRRVLGP
                     RHPETLMVRADHATFLREHGDLGHARDLAEEVAERYRALAGERHPYTVGTLGNVGLVRG
                     EFGDPADALDLAERALSGMAEAMGPGHPWTLGCALNTAAARNRVDDEEGAVELGRDTLE
                     RAKARLGDTHPLTLSAKTALSEDLRALRRGQEAAKLEQEAIQQLSENLGAEHPHTLSAR
                     RRRRPYWDFEPQPV"
     gene            complement(14778..18566)
                     /locus_tag="HEP86_RS27375"
                     /old_locus_tag="HEP86_27375"
     CDS             complement(14778..18566)
                     /EC_number="4.1.1.71"
                     /GO_function="GO:0004591 - oxoglutarate dehydrogenase
                     (succinyl-transferring) activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950819.1"
                     /locus_tag="HEP86_RS27375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27375"
                     /product="multifunctional oxoglutarate
                     decarboxylase/oxoglutarate dehydrogenase thiamine
                     pyrophosphate-binding subunit/dihydrolipoyllysine-residue
                     succinyltransferase subunit"
                     /protein_id="WP_168481358.1"
                     /transl_table=11
                     /translation="MSLQSPNSSSISTDQEGQGKNPAAAFGPNEWLVDEIYQQYLQDPN
                     SVDRAWWDFFADYKPGGATAPSQPAEGSPGASTGSTGAAGAAQPSGPAAPAKPAASAPA
                     PAKAAPAKAAPAKAEPAKAAPAKPAAKPAAEEGTAPAGPEFITLRGPSAAVAKNMNASL
                     ELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKVSFTHLIGYAMVQALKAMPTMNYSF
                     AEKDGKPTLVKPEHVNLGLAIDLVKPNGDRQLVVAAIKKAETLTFFEFWQAYEDIVRRA
                     RDNKLTMDDFTGVTASLTNPGGIGTVHSVPRLMPGQSMIMGVGAMDYPAEFQGTSQDAL
                     NKLGVAKVMTLTSTYDHRVIQGAASGEFLRIMSQLLLGDNEFFDDIFKSLRIPYEPVRW
                     LRDIDASHDDDVTKAARVFELIHSYRVRGHVMADTDPLEYHQRKHPDLDITEHGLTLWD
                     LEREFAVGGFSGKSMMKLRDILGVLRDSYCRTTGIEFMHIQDPKQRKWIQDRVERSHKS
                     PEREEQLRILRRLNSAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAAESRLDE
                     VVIGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKYHLGQEGVFTGLDG
                     EQIKVSLAANPSHLEAVDPIVEGIARAKQDLINKGGTDFTVLPIQLHGDAAFAGQGVVA
                     ETLNMSQLRGYRTGGTVHVVINNQVGFTAAPESSRSSMYATDVARMIEAPIFHVNGDDP
                     EAVVRVARLAFEFRQAFNKDVVIDLICYRRRGHNESDNPAFTQPLMYDLIDKKRSVRKL
                     YTESLIGRGDITLEEAEQALQDFQGQLEKVFTEVRDATTAPTAPEVPQPKAEFPVYVDT
                     AISQEVVKRIAESQVNIPERVTVHPRLLPQLQRRAAQVEDNTIDWGMGETLAVGSLLME
                     GTPVRLAGQDSRRGTFGQRHAVLIDRETGDDYTPLLYLSEDQARFNVYDSLLSEYAAMG
                     FEYGYSLARPEALVMWEAQFGDFVNGAQTVVDEFISSAEQKWGQTSGVTLLLPHGYEGQ
                     GPDHSSARIERFLQLCAQNNMTVAMPTLPSNYFHLLRWQVHNPHHKPLVVFTPKSMLRL
                     KAAASRTDEFTTGGFRPVIGDSTVKPEDVRKVIFCSGKVYYDLEAEREKRGAHDTAIIR
                     IERLYPLPGKELQAEISKFPNAEKYLWTQEEPANQGAWPFLGLNLIDHLDLAVGADVPH
                     GERLRRISRPHSSSPAVGSAKRHQAEQAQLVAEAFDA"
     gene            complement(18804..19928)
                     /locus_tag="HEP86_RS27380"
                     /old_locus_tag="HEP86_27380"
     CDS             complement(18804..19928)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087456.1"
                     /locus_tag="HEP86_RS27380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27380"
                     /product="ATP-binding protein"
                     /protein_id="WP_168481359.1"
                     /transl_table=11
                     /translation="MTRSPRTRLTELWQRVWEGLRPLDPYRSVKAALGALVSVSVIITT
                     LLVFVAMHSATELRVITIFSIIASLLITQFVANSLTAPLDEMTDVTRSMAHGNYSRRVR
                     SERRDEFGDLATAFNRMAADLEAVDTHRKELVANVSHELRTPIAALRAVLENVVDGVCE
                     PDPETMRTALQQTERLGRLVEHLLDLSRLDNGVVPLHSRRFEVWPYLSGVLKEANMSRG
                     AATLAGVAGSGTHTRTDVHLHLDVSPPELTAHADAERLHQVVANLIDNAIKHSPRHGRV
                     TVHARRGEGPQSLVLEVQDEGPGIPEAERYRVFERFNRGGPAPSGPGSDGGTGLGLAIA
                     RWAVDLHGGRIGVAESSRGCRIRVTLPGLESARS"
     gene            complement(19925..20665)
                     /locus_tag="HEP86_RS27385"
                     /old_locus_tag="HEP86_27385"
     CDS             complement(19925..20665)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536131.1"
                     /locus_tag="HEP86_RS27385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27385"
                     /product="response regulator transcription factor"
                     /protein_id="WP_168481360.1"
                     /transl_table=11
                     /translation="MDQTQTTQGGAAAATPGAQRRVLVVEDDPTIVEAIAARLRAEGFQ
                     VQTATDGPAAVDTAEAWQPDLLVLDVMLPGFDGLEVCRRVQAQRPVPVMMLTARDDETD
                     MLVGLGVGADDYMTKPFSMRELAARVHVLLRRVERAALAAHTPRTGILRLGELEIDHAQ
                     RRVRVRGADVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKAL
                     RRKIGAERIRTVHGVGYALETPAA"
     misc_feature    complement(20676..20689)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            complement(20739..21503)
                     /locus_tag="HEP86_RS27390"
                     /old_locus_tag="HEP86_27390"
     CDS             complement(20739..21503)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087454.1"
                     /locus_tag="HEP86_RS27390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_27390"
                     /product="spermidine synthase"
                     /protein_id="WP_168481361.1"
                     /transl_table=11
                     /translation="MASATPTQARTGAPEAPRTLDRREGPFGEVVLRQRGGSPAAPGAD
                     GGGTPAAPAIYEIIANGCFLMDTSDGRSERLLIDAALDALPAGRAHPSVLIGGLGVGFS
                     LARAAQQPRWGRIVVVEREEAVIDWHRTGPLSAVSAAALADPRSEIRHADLVAHLRTEA
                     GQDTYDALCLDIDNGPDWTVTEDNDSLYSPDGLAACRDRLAPGGVLAVWSAQPSPAFEE
                     ALRNAGFSGVHTEEIPVVRGVPDVVHLARKGA"
ORIGIN
        1 ctccttggcc cgccgggcct gctccttcca ctcctccttg gcgcggcgga actcctcctt
       61 cgcctgctgc caggactcct tgtcgccgaa cgcgccgtcg aagtagtcgg cggcgtccgg
      121 gtacggccgc ccgccggcgc cgtccccggc gtccgcggtc ccgtcaccgg tccgcccggc
      181 cgttccggag ccccgggcgt cccggcgggc ctgctgggcg gcttcccgga tctcgcggcg
      241 cagatcccgc gccgaaccgc tgacgtcctc ccggatatcg gaggcgagcg cggcgaccga
      301 ctcccggatc tccagttcga ggtcggccaa ctcgccgcca cggtcggcga gttcggcccg
      361 gccggcgtcg gtgagcgagt agaccttgcg gccgccctcg gtcgtgtgcg tcaccagtcc
      421 ctcggccgcc atcttggcca gccgggggta gaccgtgccg gcggaggggg cgtagaggcc
      481 ctggaaacgt tcctccagga ggcggatgat ctcgtagccg tgccgcgggg cctcgtccag
      541 cagcttgagg aggtagaggc ggaggcggcc atgggcgaag acggggggca tgctcagagc
      601 accttcttct cggcgggcgg gtcggtgggg agtcccctgc gggccggggg ccgggccgaa
      661 gccgtccggg ccgggggccg ggccgccgcc gaagccgtcc ggccggtcct cgtcctcgaa
      721 ggcggggcgg cggagcaggg ccagaccgcc ggagacggtg gtgaccttga gggtgccggt
      781 gcccgcgccg agcgcgccgg tgatcttctt ggcgccccac cggccggtga cccgcagcgc
      841 gtcgaaggcg ttggagaccg tgccgctcgc ggtgttggcc tccaccgtgg cgtcggccgg
      901 gtcgggcagc cggatggcga cctccccgga gaccgtggtc agcgcgatgt ccgcgccctg
      961 ggcggggtcc aggtccatga ccatgtcgcc gctgacggag tccgcgcgca ccgtcccgcc
     1021 cgccccgtcg atgaccgtca gatcccccga gacggagtgg aaccgcagat cgccggtgac
     1081 cgactgcacc tcgacattgc cggagatggt gtcggcctgc accctgccgg tcagcccgac
     1141 gagcgtggcg tcaccggaga ccccgcggac gtccgtgcgc cccgagatgc cggagaccac
     1201 cgcggcggcc ccgaccacgc cgacctcgac gcgggtgccg gccggcaccg tcaccgagat
     1261 caccgcgctg cggttccagc ccttgcgttc caggaacttc aggaagccct gccagggcag
     1321 atcgtcgtag gcgaccgaga gggtgccgtg gtcgcacgag acggtcagcg gtgggccgtg
     1381 cagctcgctg acctccacac gggccggact gccatccgag gtgccgacga cgttgacggt
     1441 gccgccgacc acgcgcacgt tcagggcgtc gagggggtcg gagatctcca gcgtgcgtgg
     1501 ctcggccacc tgcatcggtc gcgaccactc gctccgggct gacattcctg gcctcccctg
     1561 gatagccaca cacgcaacat atcgcgtctc gtgaggacac gatatatcgc ggatcggcga
     1621 agtcaagcgc cggtcccacg cacgggtgac ggtcgccgcc gggagcgacc gcgcgccgtg
     1681 gaaggggagt cctcgtcggt gaccaccgct gtcacggcgt atgccgtaga ggagttcggc
     1741 gagccgggcg ggcagcttca agaaggccgc gaagcgcaac catgcgaccg aggggaagat
     1801 cgtcaacgcc ctggcggtgt gcgggcacgc gcgtcaccgg gcggagatcc ggcacgccct
     1861 cgacgccgcc cggaaccaca tccagggcgc cgaacaccac aacaagaagg cctgcatcga
     1921 gcacgaccgg ccgtatgggc gggcagccct caacggcgag tacgacgcgc agcgccgtct
     1981 gcgcgacgcg gcccgctact cctgatccag ggttccgcca cgacggtccg cctccctccc
     2041 aggggcggac cgtccgcgca ctatccggcc accggagagc cggagcgacg cggccccggc
     2101 ccgctccccg gcggcctact cgtcctcgtc ctcgtcgtcc aggcgggcca gccaggtggc
     2161 cagccgctcc accggtacct cgaagtccgg attgaggtcg acgaaggtac gcagctggtc
     2221 agccacccac gccagggtga cctcctcctc gccgcgccgg ttctccagct cctcgatgcc
     2281 acggtctgtg aaatacacgc gctctccacc aggggtcatg ggtgattccc ggccaggata
     2341 ggcaggctca cggacctctc gcgccacaga cgcccgacgg ctagcctgat cacctgtcaa
     2401 cggtcctgcg gcaattggga aattgccgcc cacggggcgc aggaggccgt gatgcaagat
     2461 cgcgcacagc gcatcgaact tcccgacggt acggaagtct gggcccgggt ctcccggctc
     2521 gacaccccgg caccggacgg gacggacgac gcggacgggg aattcgagga cgtcggcgcc
     2581 tgggacgcgc tcggggcccg ggtcgagggg ctccgcgagg tgatcggcgg ggtcgccgcc
     2641 agcgtccggc aggccaccga acgggtcgcg ccgcacgaga ccagtgtgac cttcggcgtg
     2701 gagctgtcgg ccaagccggg taaggccgtc gccctgctcg cggacggcga ggcgaagagc
     2761 aacctctccg tcaccctcac ctggcggcgc gaggaccggg cgccgaccgg ggacgcgcca
     2821 cacgaaccgc atcccgccga ccgccgggag ccggacgatt cgagccgctg atgtcgacct
     2881 ccgagggccg ggccgccggc cgcggtgacc gcgcccgcta cacacagctc ctcgaccacg
     2941 ccggacgcac caccgtcgcc ctgcgcgccg ccccgggcgg ggccgccgcc cgcccgtggg
     3001 gcagcggcgt gctgatcgcc ccgggatggg tgctgacctg cgcccatgtg ctcgcggcga
     3061 gcgacgggcg gcgccgcgag acgggcccgg acggggtctt cggcgtcacc ttcgacggcc
     3121 gggtggtgcc cgcccggctc gcctacgacc tgagcctccc cgacccggcc gccgggcccg
     3181 ccgccgcccg cgccgacctc gccctggtcc agctgctcga cctggagacc gaccacccct
     3241 gcgcctggct cagcgatcag ccggcgacgc tcctggagga cgcttacatc ttccgcggcc
     3301 acgacgcgtc gggcgcggtg acccaagggg acggcgacgc gggcacgggt caccgggggg
     3361 aacgcgtcgt acgggaggcc ggcggcgcgg gtgacccgca ggacgggagc cccgggcccg
     3421 agccgggcgg cggacgcggc acccgggggc gcgccgagca cacggcgccc gccggtccac
     3481 gcgcccccgc accccccatc gaccccttca tcgcggtccg tttcggcgcc cgcgacgccc
     3541 ggggtctcca gttcggcagc gatgtccggg tctcaccggg cgcctccggc gggccgctgc
     3601 tcgactgcga ccgcggtgag gtggtcggca tcgtcaaggg ccgccaccaa caagaccatg
     3661 tcgggctggc ggtgccggtc acggcgctgc gcgggctcgg gccggaacac ctggtcgcgg
     3721 gcgccgaggg cctggggccc gacccgtacc acgcgctgat gagcctgcac gaccgctggc
     3781 actgggccgg tcaggatctc ggccggaccg ccgggcccac ctggttcgac gcccagcaca
     3841 tgatcatggc gggccggggc cgtctgtggg gcgtccagga gcggctccag gcgctggacc
     3901 tgctcgcccg gctgcccgca ccgcgcgacc cgctggtcgt ggaggccgcg gtcggcgagg
     3961 tgctggagcg cggcgagcgg cccggggcct ggctgctgcg tacctggcgg gacgggcacg
     4021 gcgccctcta ccagggcagc gacccgtaca ccgagctgcg cgcctttgtg cactatctgc
     4081 ggatcgtggc gcagctgacc gccgacgagg tgcgcgacgc cccgggcgac gaggccgccg
     4141 cggtccgcga acaggccgcc aggctcgcgg agttcgtgca ggccaaagcg gtggttctgc
     4201 agccgcagga ccgccggagg ataggacccg tacgccgccg gccgcgctcc gtgctcgtcg
     4261 agttcgagcc gctcttctac gacgagggcg ggcaggagct gttcaactgg tcggtcagcg
     4321 agggctacgg ccagggtcag tggctgcggg tggacgtcca ggagtcggcc ggcggggtgc
     4381 cgttcgagca ggcgcgggag caggtgctgc ggcggctcgg cgggcggctg ctgcgggccg
     4441 acggggacgc cgggccgaat gcccgggtac gcctggaggt cgccgtcccc gaagggcgct
     4501 gggacaccgc cgccggccag tgggaggtgg cggcctcgac ccggcgcacc gcccggctgc
     4561 ggccggtggg ccccgggcgc gcggtgatcc tgcgcgacca ggggcggcgc gaacaggtcg
     4621 acccggcctg gctgcgccgc tggcagggcc tggccgccgc ccgtgagctc caggccctgc
     4681 gcatcccgcc gcggccgggc gccgacgccc ggtccggttc cgccgaggcg atctggcggc
     4741 tgctggagac ggccggcgag ggcgcgctgc cggcgctgtg ccacaccgtc gccgacgggt
     4801 tcggccggga cgcggtcggc gtcgccctgg acaccggctt cccggccggg ctgtggcccg
     4861 cccacgggca cggcgaggag cgggactgcg acgccggctg cgaggagttc caccgcgggg
     4921 tgcgggagct gctccagggg tcgggcgggg tggcccggct ccccgaactg gtccggcagc
     4981 tgcgggccaa ggccgcggag gccgcggagg agggcacgca ctgggcgcgc gatctggtgc
     5041 tcctctacga cgacccggag gacccgattc cgccgctctt cacggaccgc ccccagatgt
     5101 cgccgcgatg aggagtacgg ggcgccgccc cctggcgctc cgggcgccgt gtacgccccg
     5161 tacacctcgc acgcgcccgg tgcccggccg ggcggcatcc gcccctgctg cggcaagtca
     5221 cgccccgtac ctggcacttg agcgcccgcg atgcccgcgc gggagaccgg aaaccgcccc
     5281 gtgtgcttcc gtccgggtgg gtactgtcat agcgtcgtgg aagacttgtt cgtgaggacg
     5341 cgactgcgtg atggtgggtg gcggacgcgg gggggaggcc gagcggatgc cgagatctcc
     5401 ggcggtccgc catgaccctc actcctgacc gaggcctggc cggcgacgag gagttccgac
     5461 gtgagcgact ggctcatcta ccgtggcgcg ggggcaccgc acgacggaat tgagcatctt
     5521 ccgccgccgc ccccctggcg cgatttcgac ggcggccccc tcgtggcgcc gccggccgcc
     5581 ctcgacccct cttccgagcg caggctcggc gtgcagcacc gggaggccag ccaccaccgc
     5641 cccggcgaga ccgagcgaga gctggtcaac gccgccctct atctgcgccg cccgctgctg
     5701 gtgaccggcg caccgggcag cggcaagagc accctggccc attcggtcgc ctacgagctg
     5761 ggcctcggcc gggtcctcgg ctggccggtc gtcagccgca gcacgctccg tgacggtctg
     5821 tacgactacg acgccatcgg ccgcctccag gacctccaga tcgcccgcgc cgccccggct
     5881 gccgcggacg acgcggcggc gcccggcccg gaccccacgg acgaaccggg cggcggtatc
     5941 ggccgctata tccgcctcgg cccgctgggc acggcgctgc tgccggccgc ccggccccgg
     6001 gtgctgctcg tcgacgagct ggacaagagc gatatcgatc tgcccaatga cctcctcaat
     6061 gtgctggagg aaggggagtt caggattccg gagctggagc ggctggccgg atccgccccc
     6121 gaggtggagg tgctcagcga cgacggcacc cgggtcacgg tgcgcgacgg ccgggtgcgc
     6181 tgccgtgcct tccccttcat cgtcctcacc agcaacggcg aacgggactt cccggcgccg
     6241 ctgttgcgcc gctgcatcca cctccacatc ccggtgcccg acaaggagcg gctcgccgcc
     6301 atggtgcggg cgcacttcgg cgagggggcg gcggagcgct acgaagcggt gatcgaccgc
     6361 ttcctggacc gcgagcccgg cgatgtccgc gccgtcgacc agctcttcaa cgccatccac
     6421 ctgacccaga gagcgggctg gacggacgag gacgaggagg agacgcgccg gcgtctgacg
     6481 gcggagctga tgcggcctct tgaccggacg aggtgagtcc ggtgcccccc ggggagcccg
     6541 gcccgggccc cctcgacgaa ctcgtcgccc ggctgaccgc ggcggggctg ccggccgacg
     6601 cccgcgggat ggccgatgcc ctctggctcg cccagtggat caccccgggc ccctcgcggg
     6661 cccagagcgc cgcggatgcc gggcccaccc acggggaccc tccggaccgt acagattcag
     6721 ccacattccg ggtgggacct tccgcatccg ctgagtccgc ggggacgggt ggggcggcac
     6781 cggacggcag tggtaccgaa acggcggacg gtgaccccgc gccgcccgtg ctccaggagg
     6841 gcacccggcg ccgggtcgcg gagctgctgc ccacccgtga cccgggggac gcgcgcttcc
     6901 ccgacccgga ccggcagcgc ctgggcgagg tcgcggtccc gatcgcctcc gcgttccccg
     6961 gactgctgcc gctccagcgc gcgttgcggc ccatccagcg ctaccgcccg ccggtcgccc
     7021 cggtcccccg gcggctggac gagcccgcca ccgccgagct ctccgcccac gccgaaatga
     7081 tcatcccggt gctccgcggg gtgcaccgcc gggcggccgg tctgcggctc ctgatggacg
     7141 gctcgtcctc gatggccgtc tgggaacaga tgctgcacga cctgcgccag gtctgtgagc
     7201 gggtgggcgc cttccgcgat gtcaccgtgc actacctgca tccgcacggc ccggacgtgg
     7261 gcgtcgcggc ggccccgggc cccggccgcc cgttgcgccc cgccgaccag ctgcacgacc
     7321 cgacgggcca tcacctcacc ctcgtcgtca gcgactgcgc gggccccctc tggcgggacg
     7381 gccggatgca gcggctgctc taccgctggg cggccgacgc cccgctcgcc gtggtccagc
     7441 cgctgccgca gcggatgtgg gcgcgcacgc tgctgcccgc cgtcgccggc accctcgtcc
     7501 gccgccaggg cccctaccag gccctcggtt tccgcccggc ccggcgccgc cgccgtcccg
     7561 ccggacctcc gggcgccgcc gaagcgcccc gcgagcgcgc cgttccggtg ctgtccgcca
     7621 ccccgtccgc cctcggctcc tgggcccggc tggccgccgc cgacgccggt ctctcgctgc
     7681 ggcgcggcct ccgtcgtccg ggccgaccac ggcgccgggc atccggccgg accgccgccc
     7741 gcgtccggga cggccgcgcc ggcccgtatg gtccgcgagt tcgaccagca ggcctcaccg
     7801 gccgcccggc tgctcgccgt gcatctgtcg gccgtgccgc tcgcgctgcc cgtcatccag
     7861 ctcgtccagc gcgcgatgct gccgcagacc ggcccggccg agctggcgga ggtgctgctc
     7921 agcggcctgg tcacgcaact cccgccggac gagcggccgt cgggggagca ggccggggtg
     7981 agcggcccct ggtacgactt cgtgcccggt gtacgcgatg aactcctcgc ccggctcagt
     8041 gcgggggagg cggccctggt gctcaagcac tgctcgctct acgtcgagcg caccttcggc
     8101 cgcagcgccc gcaacttccc ggccgtcgcg gtcgccatgc tctccggcag cggccgggag
     8161 cccgagaccg gccagcgggc cgtccccgaa cccttcgccc gggtctcgga acgggtgctg
     8221 cgccgcttcg aacccgcctt gcgcccgccc gcccggcggc cgtacgcgac cgacgggccc
     8281 gccgcggaag gcgcggccct cctggagcgc tacgagcagg accgtgccgg ccgggatctg
     8341 atcgaggcgg tccggctgct gcgcgccgcc accgaacgcc tgccggtagc cggcaccgac
     8401 ctcgcccgcg cactgctgca cgcctgggcg acctggcgcc agccggacgc cctggaggag
     8461 gcggagcgcg cggcccgggc gccgaacggg ccaccgcggg cgagcccgtc gatgacctgg
     8521 aaggtgccgc ggcgggccgg gaggccgagc gcacccgggc gctgatcgtg ctcggccggg
     8581 tcggccacgc ccgcgcccgg gagcgccgcg cggccggcac ccccgccgag gagcgcaccg
     8641 cgctcgccga cgccgcccgc catctgcacg ccgcctgcgg gctgatgagc ctgctggacc
     8701 cccgcgtcct ggagagcatg gtgttacgca ccgaggtcct gcgccgcctg gccgccctgc
     8761 cgcccgtacc gaccaccgac ggggcgaccg accccgaccc gctcgacgag gcggaacgct
     8821 ccctcaccac gctcctcgac cagtggccca gcggagagca ggtgccgggc gaggtctatg
     8881 cggcccgcgg cggtgtgctg ctcgaccagg cccggcgggc cgcccgcggc gacaccgcgg
     8941 ggccgcgccc ggccgaggcg ctcgccgtcc gcgccgccga cgacctcgac accgccgcgg
     9001 tcctgctgcg ccgccgtggt ggcgcggccg accggctggt ctgcgagacc ctgctcgacc
     9061 tcgcggcggc ccgccagctc aacggcggcg cgggcctgcc gtccgtgctg cccaccctcg
     9121 aacacgcccg tgcgctcgcc catgaactgg acgaccgggc cctggaagcg gacagcctgc
     9181 gccgtacggc cgccgcccag cgcgccgtac acacccgcac cggcgagctg accgcgctgg
     9241 acgccgccat cgccgcgctg gccgccgccc tccggctgac cactcccgat tcgcccgagc
     9301 acagcgcgct gctggccgag cgggggcggc actgctgctg cgcgcccggc tggaaccggc
     9361 cggggaaccg ggcaagcggc tggccaacga ggcggtgcac gtcctgcgcg aggcgctggg
     9421 ccgggtcggc ccgcaggacc ccgacctggg cagtcaccgg ctgctgttcg gccgcgccct
     9481 gcggctgcgc tacgagcgcc agccctcgct cgccgatctg cacgaggccg actggatcct
     9541 ggagctggcc gcccgcggcg cggacgtacc ggacgcggtg gcggccgagg cctggctcga
     9601 agtgggcgat gtgcagctgc tgctggatgc ccgcttcgac tcccgtgagc gccatgaccg
     9661 ggccgccgcc tgctaccgcc gggccgccgc ggccgcccgg agggccgaca gcgcgctgcc
     9721 ggccgcccgc gcccaccacc gccgcggcga ggtcctggag gtcaccgccg gaccccggtc
     9781 cgcgctgcac gcctaccgcg agagctggga gcagtggcag cgggccggcg aggacaccgg
     9841 cccggaggcc cagcgcaccc gcgcccgtat gcgcgccctg gaatccaccg cctgaccgcc
     9901 ccgagcaccc cgtccggctg cctggccgtc cgcaccggaa cgtgtttctg tggacggcag
     9961 ttcgggaaca cacccgtcca gccggcctga ggagagcagc gtggcgacta ccccccgcac
    10021 cgaaccggct gtggccgccc cgccggggcc gtcggccgag cggctgccgg acttcgccgg
    10081 ggttgacgtg ggcgttctgg cggcacggac cggccatgcg gtgctgggtg aggtggcggc
    10141 gctgctgctg cgcaactggc cgtcggcgga ggacgccgtc gcctattacg aggacggtcc
    10201 ggagaaggcc ttgcactgac agtcgagaac ggttgttttt gggcaaacgt gcaaggaaac
    10261 cggccagttg ctgggggaat ttggttcttc acccgagggc ggagccatgt accaggcaac
    10321 gggccggaat tgccgagccc gtacctcgac gcaggcagac gagagcaggg ggcgacccgt
    10381 ggcgggggag aagaccggcc cgaccgctgt cgtgcccttc cggcagttcg tactcaaggt
    10441 ccacagccgc tgcaacctcg cctgcaccta ctgctacatc tacgcagggc cggaccgcag
    10501 ctggcgcgcc cgcccaccga ccgtcccggc cgccaccatg cgccagaccg ccctgcggat
    10561 cgccgaacac gcccgcaccc accggctgcg cgaggtccgg atcgatctgc acggcggcga
    10621 gccgctgctc accggccccg gaccgctgct ggcccaggcc gccgcggtcc gcgccgcgct
    10681 gcccgccggc tgcaccgccg cattcggggt gcagaccaac gggacgctgc tcacccggga
    10741 catgatcgac accctcgccg ccgccgggtt ccggctcggc ctcagcctcg acggcggcac
    10801 ccccggcctc aaccgccgcc gtatcgacca cgccgggcgg ccctcctggc ccgcggtctc
    10861 ccgcgccgta cgcctgctcc acgaccggcc cgaggtcttc gccggcatcc tgtgcaccat
    10921 cgacatcacc gccgcccccg gcgaggtcta cgactcgctg cgcgccctgg accccccgat
    10981 ggtcgacttc ctcctcccgc acgccaactg gaccagcccg ccgcccgccc ccctcggccc
    11041 ggccggccgc accccgtacg gcgactggct gtgcaccgcc ttcgacctgt ggtgggacgg
    11101 cggccccggc ccccgcgtac gggtcttcac cgaaatcctc ggcctcctcc tgggccgccc
    11161 cagctccagc gaggcggtcg ggctctcccc ggtcgtcgcc ctggtcgtcg acaccgacgg
    11221 cgccatcgaa caggtcgact cgctcaaatc cacctacgag ggcgccgccg ccaccggcct
    11281 cgacgtcttc caccacgcct tcgacgacgc cctggcacac cccggcatgg ccgcccgccg
    11341 gagcggccgg gacggcctcg gcgcacagtg ccgaggctgc gccctggtgg aggtctgcgg
    11401 cggcggcaac tacgcccacc gctaccgcgc ggacgccggc ggcttcacca acccgtccgt
    11461 ctactgcgcc gacctggagc gcctgatccg gcacatcgcg gcccgcctga acgccacggt
    11521 cgcgctcaac tgacctgcgt ccgagatgac ctgacgcact gtcgtcatat ggagggacac
    11581 ttgggctatc gtgccaaaga gccagggcgt gcctgatgag acagcctctc cgcgcgcgca
    11641 ccatcgcatc ccagggagac ggtcgcatgg tcgatcaggc ccatttttcc ggtcccaccg
    11701 gctccaacga acacatcacc atcagctacg cgggcttcac ccggccctgg gccgcctgga
    11761 tctcccatca gctggagcag cagggccacg gcacgaccat gctgcgctgg gaccctcagg
    11821 tggacaccgc gctggtggcg gagctgtcgg gactgctgga ggccgagggc cggctgctga
    11881 tggtgctgga cgactggtat ttccggctgg gccccaagac gcaggacgag tggacggccg
    11941 cactgcgcga ggtggtctcc gcgcacgccg accggttcgc cgcggtgagc gtggccaccc
    12001 agagcctgcc cgccacggcc tccctgctgc gccccgccga cctgcgtgac ctggatgccc
    12061 acgaggccaa ccgccgggta ctgcagcggc tcggtatcgc ggcgccgggc cgggccgtgg
    12121 acgaggacgc gcccggcgcg ccgcgcttcc cgaacaaccc gcccgaggtg tggaacatcc
    12181 cgcgccgcaa caaccgcttc accggccgcg accacgtcct cgaagcgctg cacggcaagc
    12241 tggccggctc cggcgcgggc gcgggcccgc cgctggagac ccggatcgcg ctgtacggca
    12301 cctccggcgt cggcaagagc cagatcgccg ccgaatacgc ccaccgcttc ggcaacgact
    12361 acgacgtggt gtggtggatc agcgccacca accgcggcgc cgcccgcgaa cagctcgccg
    12421 aactcgccac ccgcctcggc ctccccgtgg gccgggagct gggcgaccgc atccgcgccg
    12481 tccacgaagc gctccgcgtc ggccgcccct accgccgctg gctgctgatc ttcgacagcg
    12541 ccgacgacat ggagcagatc gaggacctgg tcccggacgg ccgcggccat gtcctgatca
    12601 ccaccctcac ccgcgactgg tcgggctccg gcagcgccca ggagatcgag gtgccgccct
    12661 tcgagcgcgt cgagagcgtc gcctacgcac ggcggcgggc cccccggctg acgccgatgg
    12721 aggccgacct gctctccgag gcggtccagg acctgccgct gctgctcgcg cagaccgccg
    12781 cctggctcga cgccaacccg atgtccccca aggagtacat cgagctgatc cgccgcggcg
    12841 agcccagcct cgtcggcatc cggatctcct ccgactaccc catggccttc cagacgagct
    12901 gggccataac tctcaacacg ctgcgcgaac gcagcccggc cgcggtcgaa ctcctcaagc
    12961 tgttcgcgtt cttcgccccg gacaccatcc ccgtaccgat gctcgcccgg gcccgccgcg
    13021 gtgacctgcc cgagcacctc gccgacctgg ccgccgagcc gatcagctgg aacaccgcgc
    13081 tgcgccggct gaccgagtcc accgccgtac gcctcgacta ccaggtctcc caggacgccg
    13141 acccggccgt ggagaccgcg ctgatgcacc ggctctacca ccggttcctg cgcagcgaca
    13201 tgaccgagga cgagcgcgat ctgatgtcgg cgtgcgcctg ccgggtgctg gtcaccgccg
    13261 acccgcagaa ccccgccgac acccgctact gggagcgcta cgccgaactc atcccgcatc
    13321 tggagccggc cggcgtcctc gacagccccg agcccgcggt ccagcagctg ctgctgaact
    13381 gcgtggaata tctgcgggtc cgcggcgagt accgcatggg cctgcggctg tgcgaacagt
    13441 tcatgtcccg ctggcgcacc cgcctcgcgg ccacccagcg caccatgctc gtcctcaccc
    13501 accagcacgc caacatgctg cgccggctcg gccgctaccg cgaggccgag gccgtcggca
    13561 gcgccgtcgt cgaccagctc gccgccgagc gggcccccgc ggacgccgat ctgctgcggg
    13621 cccaggacgg gctggccggc acgctgatcg cgctgggctc ctacgagcag gcctacgacc
    13681 tcttcgacgc cgtctggcgg gcctacaccg agctgctcgg cccggaggca ccccgcaccc
    13741 tctcctcgcg gcacaacctc ggcagtgtcc tcgcactgct cggccggtac gaggaagcgc
    13801 tgatcaccca tcgcgaggtg ctgtccttcc gggagcgcga gctgcgcgcc cgccaccacc
    13861 tcacgctcaa cgcgggcacc gcctacgccc gcaccctgcg cctcctcggc cgctaccgcg
    13921 acgccacctc cagccaggaa ctcaacgccc ggctgcatct ccaggtgatg ggcccgcaca
    13981 ccccgcagac cctgcgcgcc gagcacaatc tcgcgctgtg cctgcgccgc tccggcgagg
    14041 tcacccgggc cgccaccctg ctggccgacc tcgtcgagcg ctcccgccgg gtcctcgggc
    14101 cccgccaccc cgagacgctg atggtgcgcg cggaccacgc caccttcctc cgggagcacg
    14161 gcgatctcgg gcacgcccgc gacctcgcgg aggaggtcgc cgagcgctac cgcgcgctgg
    14221 ccggtgagcg ccatccgtac accgtcggca ccctgggcaa tgtcgggctg gtccgcgggg
    14281 agttcgggga cccggcggac gcgctggacc tcgccgaacg cgcgctgagc gggatggccg
    14341 aagccatggg ccccggccac ccctggacgc tgggctgtgc gctgaacacc gccgcggccc
    14401 gcaaccgggt ggacgacgag gagggcgcgg tggagctggg ccgcgacacc ctggagcggg
    14461 ccaaggcgag gctgggcgac acccatccgc tgaccctctc cgcgaagacg gcgctgtccg
    14521 aggacctgcg ggcgctccgc cgcggccagg aggcggcgaa gctcgaacag gaggcgatcc
    14581 agcagctctc cgagaacctg ggcgccgagc atccgcacac cctgtccgcc cggcgccgcc
    14641 gccgcccgta ctgggacttc gaaccgcagc ccgtctagac ctgaccaggg gtccgcccca
    14701 cgcatgcgga agggcccgcc cccaccgggg acgggccctt ccgctggtgc ctgccggttc
    14761 tccggcggcc cggacgccta tgcgtcgaag gcctccgcga ccagctgtgc ctgctctgcc
    14821 tggtggcgct tggcggagcc gacggccggc gacgaggagt gcggccgcga gatgcggcgc
    14881 aggcgctcgc cgtgcgggac atcggcgccg acggccaggt cgaggtggtc gatcaggttg
    14941 aggccgagga acggccacgc accctggttc gccggctctt cctgggtcca caggtacttc
    15001 tcggcgttcg ggaacttgga gatctccgcc tggagctcct tgccgggaag cgggtagagc
    15061 cgctcgatac ggatgatcgc ggtgtcgtgc gcgccgcgct tctcccgctc ggcctccagg
    15121 tcgtagtaga ccttgccgga gcagaagatg accttgcgga catcctcggg cttgaccgtg
    15181 gagtcgccga tgacggggcg gaagccgccc gtcgtgaact catccgtccg cgacgccgca
    15241 gccttcagac gcagcatcga cttcggggtg aagacgacca gcggcttgtg gtgcgggttg
    15301 tggacctgcc agcgcagcag gtggaagtag ttcgacggca gggtcggcat ggcgaccgtc
    15361 atgttgttct gcgcgcacag ctggaggaac cgctcgatac gggccgagga gtggtccggg
    15421 ccctggccct cgtagccgtg cggcagcagc agggtgacgc cggacgtctg gccccacttc
    15481 tgctccgccg aggagatgaa ctcgtcgacg accgtctggg cgccgttgac gaagtcaccg
    15541 aactgcgcct cccacatgac cagcgcctcc gggcgggcca gggagtagcc gtactcgaag
    15601 cccatcgccg cgtactcgct gagcagcgag tcgtagacgt tgaagcgggc ctggtcctcg
    15661 gagaggtaga gcagcggcgt gtagtcgtcg ccggtctccc ggtcgatgag caccgcgtgc
    15721 cgctggccga aggtgccacg gcgggagtcc tggccggcga gccggaccgg ggtgccctcc
    15781 atcagcagcg agccgacggc cagggtctcg cccatgcccc agtcgatggt gttgtcctcg
    15841 acctgggccg cgcggcgctg gagctggggc agcagacgcg ggtggacggt gacccgctcg
    15901 gggatgttga cctgcgactc ggcgatccgc ttgacgacct cctgggagat cgcagtgtcc
    15961 acgtagaccg ggaactcggc cttgggctgc ggcacctcgg gggcggtcgg ggcggtcgtg
    16021 gcgtcgcgga cctcggtgaa gaccttctcc agctggccct ggaagtcctg gagcgcctgc
    16081 tcggcctctt ccagcgtgat gtcgccgcga ccgatgaggg actcggtgta gagcttgcgc
    16141 accgagcgct tcttgtcgat caggtcgtac atcagcggct gggtgaaggc cgggttgtcc
    16201 gactcgttgt ggccgcggcg gcggtagcag atcaggtcga tgacgacgtc cttgttgaac
    16261 gcctggcgga actcgaaggc cagacgggca acgcggacga cggcctcggg gtcgtcgccg
    16321 ttcacatgga agatcggcgc ctcgatcatg cgggccacgt cggtggcgta catggacgaa
    16381 cgcgacgact ccggggcggc ggtgaagccg acctggttgt tgatgaccac gtgcaccgtg
    16441 ccgccggtgc ggtagccgcg cagctgggac atgttcagcg tctccgcgac cacgccctga
    16501 ccggcgaacg ccgcgtcacc gtgcagctgg atcggcagga ccgtgaagtc cgtgccgccc
    16561 ttgttgatga ggtcctgctt ggcgcgcgcg atgccctcga cgatcgggtc gacggcctcc
    16621 aggtgggagg ggttcgcggc cagcgagacc ttgatctgct cgccgtccag gccggtgaag
    16681 acgccctcct ggcccaggtg gtacttcacg tcgccggagc cgtgcatcga cttcgggtcg
    16741 aggttgccct cgaactcgcg gaagatctgc gcgtacgact tgccgacgat gttcgccagg
    16801 acgttgaggc ggccgcggtg ggccatgccg atgacgacct cgtcgaggcg cgactcggcc
    16861 gcggagtcga tgaccgcgtc cagcagcggg atgacggact cgccgccctc cagcgagaag
    16921 cgcttctggc cgacgtactt cgtctgcagg aacgtctcga aggcctcggc ggagttcagc
    16981 cggcgcagga tgcgcagctg ctcctcgcgc tcgggcgact tgtgcgagcg ctcgacccgg
    17041 tcctggatcc acttgcgctg cttggggtcc tggatgtgca tgaactcgat gccggtggtg
    17101 cggcagtacg agtcacgcag cacgcccagg atgtcgcgca gcttcatcat ggacttgccg
    17161 gagaagccgc cgaccgcgaa ctcgcgctcc aggtcccaca gggtgagccc gtgctcggtg
    17221 atgtcgaggt cggggtgctt gcgctggtgg tactccagcg ggtcggtgtc ggccatgacg
    17281 tggccgcgga cccggtagga gtggatcagc tcgaagaccc gggcggcctt ggtgacgtcg
    17341 tcgtcgtggg aggcgtcgat gtcccgcagc cagcggacgg gctcgtacgg aatccgcagc
    17401 gacttgaaga tgtcgtcgaa gaattcgttg tcgccgagca gcagctggct catgatccgc
    17461 aggaactcgc cggaggcggc gccctggatc acccggtggt cataggtgct ggtcagcgtc
    17521 atgaccttgg cgacacccag cttgttcagg gcgtcctggg aggtgccctg gaactccgcg
    17581 gggtagtcca tcgcgccgac gcccatgatc atggactggc cgggcatcag gcggggcacg
    17641 gagtgcacgg tgccgatgcc gcccgggttc gtcagcgacg cggtgactcc ggtgaagtcg
    17701 tccatcgtca gcttgttgtc gcgggcccgg cggacgatgt cctcgtaggc ctgccagaac
    17761 tcgaagaagg tcagcgtctc ggccttcttg atggcggcga cgacgagctg gcggtcaccg
    17821 ttcggcttca ccaggtcgat ggcgagaccg aggttcacat gctcgggctt gaccagcgtc
    17881 ggcttgccgt ccttctccgc gaaggagtag ttcatcgtcg gcatggcctt gagggcctgc
    17941 accatcgcgt acccgatgag gtgggtgaag gagaccttcc caccgcgggc gcgcttgagg
    18001 tggttgttga tcacgatgcg gttgtcgaag agcagcttca ccgggaccgc gcggacggac
    18061 gtggccgtcg gcagctccag ggaggcgttc atgttcttcg caacggcggc cgaggggcca
    18121 cgcagggtga tgaactcggg accggccgga gccgtgccct cctcggcggc cggcttcgcg
    18181 gcgggcttgg ccggagccgc cttcgcgggc tcggccttcg ccggagcggc cttcgccgga
    18241 gcggccttcg ccggtgccgg agcgctcgcg gcgggcttcg ccggggcggc cggcccagaa
    18301 ggctgcgcgg cgccagccgc tcccgtggag ccggtgctcg caccggggga gccctccgcc
    18361 ggctggctcg gcgcggtggc gccgcccggc ttgtagtcag cgaagaagtc ccaccaggct
    18421 cggtctaccg agttcgggtc ctggaggtac tgctggtaga tctcgtcgac gagccactca
    18481 ttgggaccga acgcagcagc agggttctta ccctgcccct cctggtcggt cgagatgctc
    18541 gagctgttgg gggactgtag cgacacggcg gcaaccgccc tcttccgctt cctaaggtgg
    18601 tggacagcgg gaataaaggc tacgcctgtt gtgacccttg atgcaggccg ggaggggcac
    18661 tcgtcgtgta cgtcacattc ccggccgggt ttcggggcat gacttggcgg gaaacacacg
    18721 aagtttgcct ctgtgcgggt aggagtgatc accaccacac ccgcggggga gtgcttccac
    18781 caccgaccct acgtcagcgg ccgtcagctt cgagctgact ccagccccgg aagagtgacc
    18841 cggatccggc aaccacggga cgattccgcg acgccgatgc gtccgccgtg cagatccacc
    18901 gcccagcgcg cgatcgccag gcccaggccc gtaccgccgt cgctgccggg gcccgagggg
    18961 gccggaccgc cgcggttgaa ccgctcgaag acccggtagc gctccgcctc ggggatgccg
    19021 gggccctcgt cctgcacctc cagcaccagg ctctgcggcc cctcgccccg ccgggcgtgc
    19081 accgtgaccc ggccgtgccg ggggctgtgc ttgatcgcgt tgtcgatgag attggccacg
    19141 acctggtgca gccgctcggc gtccgcgtgc gcggtcagct ccggcggcga gacatccagg
    19201 tgcagatgga cgtccgtacg ggtgtgggtc ccggagccgg ccaccccggc gagggtcgcg
    19261 gcgccccggc tcatattggc ctccttgagc accccggaca gatacggcca gacctcgaag
    19321 cggcgggagt gcagcggcac caccccgttg tccagccggg acaggtccag gaggtgctcg
    19381 accagccggc ccagccgctc ggtctgctgc agcgccgtac gcatcgtctc cgggtccggc
    19441 tcgcagacac cgtcgacgac gttctccagg acggcccgga gcgcggcgat gggggtgcgc
    19501 agctcgtgcg agacattggc gaccagctcc ttgcggtggg tgtccaccgc ttccaggtcg
    19561 gccgccatcc ggttgaaggc ggtcgccagg tcgccgaatt cgtcgcggcg ctccgagcgg
    19621 acccggcggc tgtagttacc gtgcgccatc gaccgggtga catccgtcat ctcgtcgagc
    19681 ggcgcggtca ggctgttggc cacgaactgg gtgatcagca gcgaggcgat gatcgagaag
    19741 atcgtgatca cccgcagctc ggtcgccgag tgcatcgcga cgaacaccag cagggtcgtg
    19801 atgatcaccg agacgctgac cagcgccccg agagcggcct tgacggagcg gtacgggtcc
    19861 agcgggcgca ggccctccca gacccgctgc cacagctcgg tcaggcgagt gcgtggcgac
    19921 cgcgtcatgc ggccggggtc tccagggcgt agccgacgcc gtggacggtg cggatccgct
    19981 cggcaccgat cttccggcgc agcgccttga tgtgactgtc gaccgtccgg gtcccggagg
    20041 cgtcggccca gtcccacacc tcggccagca gctgctcacg ggagagcacc gcacgcgggg
    20101 tgttcgccag gcagaccagc agatcgaact cggtgggcgt caggtggacg tcagcgccgc
    20161 gcacccgcac gcggcgctgg gcgtggtcga tctccagctc gccgaggcgc aggatgccgg
    20221 tgcgcggggt gtgcgcggcc agtgccgcgc gctcgacccg gcgcagcagg acgtgcaccc
    20281 gggcggccag ctcccgcatc gagaacggct tggtcatgta gtcgtcggcg ccgacgccga
    20341 ggcccaccag catgtcggtc tcgtcgtccc gggcggtgag catcatcacc ggcaccggac
    20401 gctgggcctg gacccggcgg cacacctcca ggccgtcgaa gcccggcagc atcacatcga
    20461 ggaccagcag atcgggctgc caggcctcgg cggtgtccac ggcggccggg ccgtcggtgg
    20521 ccgtctgcac ctggaagccc tcggcgcgca gccgggccgc gatggcctcg acgatcgtgg
    20581 ggtcgtcctc cacgaccagc acccggcgct gggcacccgg cgtggccgcg gcggcgccgc
    20641 cctgcgttgt ctgagtctgg tccatcgccc gcccctgcat gtccctgcgt ggtcgcgtct
    20701 tgctgggcag cagcgtacgg gcatggtgtg actgtcggct acgcgccctt ccgcgcgaga
    20761 tggaccacgt ccgggacgcc tcggacaacg gggatctctt ccgtatgtac cccgctgaaa
    20821 ccggcatttc gcagtgcttc ctcgaacgcc ggcgagggct gcgccgacca gacggcgagc
    20881 actccgccgg gggccagccg gtcgcggcag gcggcgagcc cgtcggggga gtagaggctg
    20941 tcgttgtcct cggtgacggt ccagtcgggg ccgttgtcga tgtccaggca cagcgcgtcg
    21001 taggtgtcct ggcccgcttc cgtgcgcagg tgggcgacga ggtcggcgtg ccggatctcg
    21061 ctgcgcggat cggccagcgc ggccgccgag acggccgaca gcgggcccgt gcggtgccag
    21121 tcgatgaccg cctcctcgcg ctcgacgacg acgatccgcc cccagcgcgg ctgttgggcg
    21181 gcgcgggcca gggagaagcc gacgccgagg ccgccgatca ggacggaggg gtgggcgcga
    21241 ccggccggca gcgcgtccag cgcggcgtcg atcagcagcc gttcggaccg gccgtcggag
    21301 gtgtccatca ggaagcagcc gttggcgatg atctcgtaga tcgccggtgc cgcgggggtg
    21361 ccgccgccgt cggccccggg cgccgcaggg gatccgcccc gctgccgcag caccacctca
    21421 ccgaacgggc cctcgcggcg gtcgagcgtg cgcggggcct cgggggcgcc ggtccttgcc
    21481 tgcgtcggtg tcgcggaagc catggcgcca tggtggccaa tacggggcgc gcc
//
