LOCUS       NZ_CP050976            20996 bp    DNA     linear   CON 06-JUN-2024
DEFINITION  Streptomyces sp. RPA4-5 chromosome.
ACCESSION   NZ_CP050976
VERSION     NZ_CP050976.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RPA4-5
  ORGANISM  Streptomyces sp. RPA4-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9051652)
  AUTHORS   Nicault,M., Bontemps,C., Tidjani,R., Gelhaye,E. and Leblond,P.
  TITLE     Mining the biosynthetic potential for specialized metabolism of a
            Streptomyces soil community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9051652)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72x/76x
            Sequencing Technology :: Oxford Nanopore GridION/Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012273495.1-RS_2024_06_06
            Annotation Date                   :: 06/06/2024 02:35:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,979
            CDSs (total)                      :: 7,887
            Genes (coding)                    :: 7,432
            CDSs (with protein)               :: 7,432
            Genes (RNA)                       :: 92
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 455
            CDSs (without protein)            :: 455
            Pseudo Genes (ambiguous residues) :: 0 of 455
            Pseudo Genes (frameshifted)       :: 276 of 455
            Pseudo Genes (incomplete)         :: 232 of 455
            Pseudo Genes (internal stop)      :: 23 of 455
            Pseudo Genes (multiple problems)  :: 71 of 455
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:36:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5737986
            Orig. end                         :: 5758982
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050976.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20996
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="21"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20996
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20996
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10996](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10996
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            376..2313
                     /locus_tag="HEP86_RS25740"
                     /old_locus_tag="HEP86_25740"
     CDS             376..2313
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089253.1"
                     /locus_tag="HEP86_RS25740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25740"
                     /product="sulfatase"
                     /protein_id="WP_168481131.1"
                     /transl_table=11
                     /translation="MPHSTRLSQPPKTKKATTTEAPPPDGPPERVPDGADADEAAADKS
                     AVDEADVDESAADEAAVDTTSETSGSTGDDTAVGSTGDDAAVGWRDRNPAVARAAGRTV
                     TALAAVLVLSALLLPNQLTRLTPGEFLRIPVEGIFGAALLLLLPPKARRVAAVVAGVGL
                     GLRTLLNCLDMGFYSVLARPFDPVLDWILFDDAESFLKDSIGQAGAIGAVLGVVLLVLA
                     LLVLMTLAVVRLTRLLVRHSAVATRTTLVLGTAWITCAALGVQLAGVPVAAANTADLVQ
                     DSAERLRASLADQQVFAKEAHVDAFRDTPPDQLLTGLRGKDVIFTFIESYGRSAIADPA
                     MASQVDEVLKDGTKRLRKAGFASRSAWLTSPTAGGGSWLAHSTFMSGLWIKNQQRYRTV
                     TSSDRMPLTDAFKRSGAWRTAGIMPGVTRSWPEGKFYGLDHVYDTHHLGYKGPQFSWSR
                     VPDQYSLSAFERLEHGKRHDKPLMSEIILVSSHNPWAPIPKMIGWDELGDGSVYDAIKK
                     AGKDPKEVWKDPAQVRNEYRRAIQYSLHSLISYMEKYGNKNTVLVFLGDHQPVPTVTGE
                     NASRDVPVALVAHDPAVLDRVSGWNWQNGLKPGPKTPVWRMDTFRDRFLTAFGPRPGET
                     KGGTPERSEH"
     gene            2455..3546
                     /locus_tag="HEP86_RS25745"
                     /old_locus_tag="HEP86_25745"
     CDS             2455..3546
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093606.1"
                     /locus_tag="HEP86_RS25745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25745"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_168481132.1"
                     /transl_table=11
                     /translation="MTIRIATFNCENLFRRPIVFSAGNDSVHNAVLEDFRKLVGILDHH
                     TYTADDKTKIIDLLKKHSVDVSQEISTQTILLNEPRGQARLLKGDGRNIEVRAEVTGRS
                     AWVGWAELVKGDLSWDAVKNTARVIAEVNADILLTVEVEDRLTLHRFNRQVLAGQFDAE
                     PYPFNMLIDGNDIRGIDVGLFSRHPITSVRSHIFDMKDSREIFSRDCPEFEIDIDGEPL
                     WLLGNHFKSKLGGGGADKRKLQGERVAQLYRAALKRSAHVVVAGDLNDTPGSPPLTFLE
                     ATSLKDAMTHDSYEGPPGTHGKCTSRNDKIDYLMFSPQLFAKVDTVEVERRGIFEFGTP
                     FDTVTGPGDQASDHAAVVAELDL"
     misc_feature    complement(2485..2496)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    2501..2515
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.41"
                     /tool="antismash"
     gene            complement(3591..4286)
                     /locus_tag="HEP86_RS25750"
                     /old_locus_tag="HEP86_25750"
     CDS             complement(3591..4286)
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089254.1"
                     /locus_tag="HEP86_RS25750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25750"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_168483977.1"
                     /transl_table=11
                     /translation="MDPEQLWSQAERPRRGRPPAHSRAAITTAAIALADAEGLAAVTMR
                     AVAARIGAGTMSLYSYVPTKETLLELMIDQVSGEHGLPTAPSGNWRADLRQFAQEQRMI
                     MRRHPWLPGALSARQTLGPNALAALEYALAVLAPVGLEAPARLETFSLLTGFVASHVSY
                     ELAQERAVEAGGPASGELLDAQDRYLRSVAAGGSYPHLAQALAVPGHDSAPQAVFDRLL
                     DRMINGLTA"
     gene            complement(4404..5141)
                     /locus_tag="HEP86_RS25755"
                     /old_locus_tag="HEP86_25755"
     CDS             complement(4404..5141)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-175). E-value: 3e-16. Score:
                     51.8. Matches aSDomain:
                     nrpspksdomains_HEP86_RS25755_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019356572.1"
                     /locus_tag="HEP86_RS25755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25755"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_168483978.1"
                     /sec_met_domain="adh_short (E-value: 3.2e-35, bitscore:
                     120.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGIEGKVVAVTGAGSGIGAATALLLAERGARLVLGGRRSERLAE
                     VVERIERAGGAAVQLRTDVTRREDLEALVALAGERFGRLDVLVSNAGVGTISPLDDLRV
                     EEWDRMVDVNVKGVLHGIAAALPVFRAQGTGHFVTVASTAAFRVVPAMAVYAGTKFAVR
                     AICEGLRQEAGDALRVTTVSPGVTATDFAEASSNSRVRAEITKMRDDIAIPPDAIARAI
                     AFAIEQPAAVDVSEVVVRPVAQG"
     aSDomain        complement(4617..5120)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS25755_PKS_KR.1"
                     /evalue="3.00E-16"
                     /label="HEP86_RS25755_PKS_KR.1"
                     /locus_tag="HEP86_RS25755"
                     /protein_end="175"
                     /protein_start="7"
                     /score="51.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVAVTGAGSGIGAATALLLAERGARLVLGGRRSERLAEVVERIER
                     AGGAAVQLRTDVTRREDLEALVALAGERFGRLDVLVSNAGVGTISPLDDLRVEEWDRMV
                     DVNVKGVLHGIAAALPVFRAQGTGHFVTVASTAAFRVVPAMAVYAGTKFAVRAICEGLR
                     QEAGD"
     CDS_motif       complement(5025..5111)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEP86_RS25755_0001"
                     /evalue="7.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="HEP86_RS25755"
                     /protein_end="39"
                     /protein_start="10"
                     /score="15.4"
                     /tool="antismash"
                     /translation="VTGAGSGIGAATALLLAERGARLVLGGRR"
     misc_feature    5119..5133
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.72"
                     /tool="antismash"
     gene            5362..6189
                     /locus_tag="HEP86_RS25760"
                     /old_locus_tag="HEP86_25760"
     CDS             5362..6189
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547060.1"
                     /locus_tag="HEP86_RS25760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25760"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_168481133.1"
                     /transl_table=11
                     /translation="MPPPPPSDQRHQLGAFLRSRRERLTPAEVGLPQTARRRTPGLRRE
                     ELALLAGISATWYTYLEQGREIRVSEQVLTALSTALRLDRHEHAHLLQLAGHAPADAPE
                     DREPLTPEAAAVPLLLQPHPAYLIDGTYDVLSHNQAAEALFPRLIDNAAQRPPNFLRWT
                     FLEPVARDIVLDWEPEARALLARLRTQSERHPADPRYPRLIDELTTHSPEARAWWPHYE
                     VQPRHSGHKRLHHPQRGPVAYAYTAFHLAEHPDRTLVVYVDAATASGQPLPGF"
     gene            complement(6261..7493)
                     /gene="mgt"
                     /locus_tag="HEP86_RS25765"
                     /old_locus_tag="HEP86_25765"
     CDS             complement(6261..7493)
                     /codon_start=1
                     /gene="mgt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535600.1"
                     /locus_tag="HEP86_RS25765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25765"
                     /product="macrolide-inactivating glycosyltransferase"
                     /protein_id="WP_168483979.1"
                     /sec_met_domain="MGT (E-value: 1.7e-44, bitscore: 151.5,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNPERKKPAHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIP
                     HLFEEKVAETGAEPVLYRTTLPSPDDDPSAWGTTLLDNVEPFLDDAIQVLPQLIEAYRG
                     DEPDLVLHDITSYPARVLAHRWGVPAVSLSPNLVAWEGYEEEVAEPMWAEPRATERGRA
                     YYERFSNWLTENGISEHPDPFVGRPGRSIVLIPKALQPHADRVDEKVHSFVGACQGERA
                     AQGDWERPVGAERVLLVSLGSSYTKKPGFYRECVKAFGELPGWHVVLQVGKHVTAEDLG
                     EVAGNVEVRECVPQLAILRKSDAFITHAGAGGSQEGLATGTPMVAVPQAVDQFGNAEML
                     QGLGVARHVPMDEADAGTLRAAVLALVDDPEVARRLAAVQREMAAEGGTQRAADLIEAE
                     LPVERGNPPVE"
     gene            complement(<7562..7663)
                     /locus_tag="HEP86_RS40850"
                     /pseudo=""
     CDS             complement(<7562..7663)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539528.1"
                     /locus_tag="HEP86_RS40850"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MARVATRLPAQDLERLRRFHSERLGLEPFDERPG"
     misc_feature    complement(7616..7618)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8067..9728
                     /locus_tag="HEP86_RS25770"
                     /old_locus_tag="HEP86_25770"
     CDS             8067..9728
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF018884.4"
                     /locus_tag="HEP86_RS25770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25770"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_168481134.1"
                     /transl_table=11
                     /translation="MRTVVYREDEPNPGDFQASASIVQAGFFCWEIATGEVSCDPLTLA
                     LHGMPESGPSGISSFLASVHESDLADVRDALGLISESCGNYQIEYRVTSDDGRHRSLEA
                     RGRVLPGADGLPARMVGVVMDTTAVHERHEAERRRLYERASRDRWMQELTAALAAAVTV
                     KDIMTAAQAGLRTFGADALAVIAPEEDRLTVVASCADDEQGEDSIGVLDATARTLVKES
                     LDRRAPVLIGSEDALRTSYPHLAPLAPSARQAWAALPLTDSRGRVSSCLVSFPEPQEFL
                     LEERALLVAAMGLLAQSLERAGMYESEHALATELQRGMLPRGPLTVPGVTIAARYQAAT
                     SGMWIGGDWYDAISLPDGGVALVIGDVQGHSVHAASLMGRLRTAVHAYANEGHPPAAVL
                     ERTNRLLTELNTDPDRALFATCCYLALTPSDGTLRVCRAGHPPPALITPRKPPRLLEVP
                     GGLPLGIDREQRYPTTRLRIAPGSVLALTTDGLLEAVNKDIDQGFERFLQGLRGAPTAD
                     LETVVDNLLAGTQKAHGLGDDVAVLLARLNRPGRRN"
     misc_feature    complement(9859..9868)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     misc_feature    9974..9987
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.77"
                     /tool="antismash"
     misc_feature    complement(9977..9991)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.25"
                     /tool="antismash"
     gene            10001..10996
                     /locus_tag="HEP86_RS25775"
                     /old_locus_tag="HEP86_25775"
     CDS             10001..10996
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="HEP86_RS25775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25775"
                     /product="hypothetical protein"
                     /protein_id="WP_168481135.1"
                     /sec_met_domain="T1TS (E-value: 7.2e-66, bitscore: 222.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENFRIPALYVPVPAALNPELQEVTAAAEAWLDEFGLVPTEEARR
                     HVQRTRVDRLTAWLCPNASREALTLITQWNGWLFQLDDQFDDDPVRGYRSEQWREAFGP
                     LFAVFDGNVTAGPLARSLADLWRRTTAVRSSAWQRRFIPHLLWYFESYRADMIHREEGR
                     IPGLQQYLAHRRASFAFDAVLDLMEIGTGVDLPDQLHANPAFADMREAVIYANACINDL
                     YSLPKELAHDYAFNAVTVICHHHRCSLQEAVERVAVMQAGYVQRILDLERVLPARLERS
                     GLADDVIADALRCVRDFHALTAGNVAWSKETGRYAEIEAKPTYLADLFIP"
     gene            11374..12162
                     /locus_tag="HEP86_RS25780"
                     /old_locus_tag="HEP86_25780"
     CDS             11374..12162
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS25780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_25780"
                     /product="hypothetical protein"
                     /protein_id="WP_211117418.1"
                     /transl_table=11
                     /translation="MEMLDLSSALSDVPPLRGQAPWPHHEYVKGWGVFGLPFASGHVLA
                     LRVFPENCFSPYRTLWHRDPNGSWSIYVDGPRLDTACPRYYGAACAHTGYARIGLTWTG
                     PATLRVTMDSPSLDWTLTASATRFLGLLNGISGALPLATWRSRLLVRARERLARALGMG
                     DLQLSGTMPSGHTGTLMPQRMYFVDDSSATFEGVDLGRPVQLTENPRIGDVPLPARGVL
                     AIGQAAWEILDPAEYERTRTETARDLSLPGEGGPEGRKAD"
     gene            complement(12556..12780)
                     /locus_tag="HEP86_RS25785"
                     /old_locus_tag="HEP86_25785"
     CDS             complement(12556..12780)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006347200.1"
                     /locus_tag="HEP86_RS25785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25785"
                     /product="hypothetical protein"
                     /protein_id="WP_168481136.1"
                     /transl_table=11
                     /translation="MSDKKAPAVGTLTLDTRSGRVGRVMDVMWSHVQLRPPQGGIEWDA
                     RPQDLRALGSRDDLSSRVAELNAHSRSGL"
     gene            12900..13643
                     /locus_tag="HEP86_RS25790"
                     /old_locus_tag="HEP86_25790"
     CDS             12900..13643
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019992735.1"
                     /locus_tag="HEP86_RS25790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25790"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_168481137.1"
                     /transl_table=11
                     /translation="MPNERLRAAMAAGGWTHATLAARAQVDPKSVERWVNLGRTPRRAT
                     ALLAAETLGEDVHALWPALRQARSARAVSSELVALYDQRADVPVSTFTDMLAEGRENID
                     VLVYAAVFLHEGFPRLNDLLRERAAEGCSVRIALGDAESENVRQRGEEERFGHGIESRC
                     RLALMHYRPLLGVPGVEIRTHGTTLYNSIYRADDQLLANAHVWGVNAYGAPVWHLRRNG
                     DGGIFDTYAQSFDAVWTTAKPVPEE"
     misc_feature    13056..13058
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13647..14117
                     /locus_tag="HEP86_RS25795"
                     /old_locus_tag="HEP86_25795"
     CDS             13647..14117
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524858.1"
                     /locus_tag="HEP86_RS25795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25795"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_168483981.1"
                     /transl_table=11
                     /translation="MSRTEYYDDPDAPEPNSLVVAASAVVPDDEGRILLQRRRDNDLWA
                     LPGGGMEMTDSLPGTAVREVKEETGLDVEITGLVGTYTDPRHVIAYTDGEVRRQFNVCF
                     TARVVGGQLAISDESTELRFIHPDEIGDLPMHHTQELRIRHFLERRERPYLG"
     gene            complement(14213..14398)
                     /locus_tag="HEP86_RS40855"
     CDS             complement(14213..14398)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007382006.1"
                     /locus_tag="HEP86_RS40855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_248001303.1"
                     /transl_table=11
                     /translation="MGCPQVRQHRWEKLKVLVLRRQLRAFCSGLFSDGKAIIVTLAGVG
                     SFVSGLAALVPGVVIH"
     gene            complement(14888..15226)
                     /locus_tag="HEP86_RS25805"
                     /old_locus_tag="HEP86_25805"
     CDS             complement(14888..15226)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS25805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_25805"
                     /product="hypothetical protein"
                     /protein_id="WP_168481139.1"
                     /transl_table=11
                     /translation="MAEQLSPEATATLQALLAGSDPVSNALLAQLPHTRVVGRCGCGCV
                     TVDLEVDRTAAAPAPSHDNPAVDAWYDAPYSAGVMVCTEGGYLSALEIYSVADQPITAW
                     TDPRFIER"
     gene            complement(15219..15884)
                     /gene="msrA"
                     /locus_tag="HEP86_RS25810"
                     /old_locus_tag="HEP86_25810"
     CDS             complement(15219..15884)
                     /EC_number="1.8.4.11"
                     /GO_function="GO:0008113 - peptide-methionine (S)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_function="GO:0033744 -
                     L-methionine:thioredoxin-disulfide S-oxidoreductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089261.1"
                     /locus_tag="HEP86_RS25810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25810"
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="WP_168481140.1"
                     /transl_table=11
                     /translation="MLFSRFKNQLPTPEEALEGRPERAFAVPDRHTVLGNPLLGPYPDG
                     LEIADFGLGCFWGAERKFWQTEGVWTTLVGYQGGHTPNPTYEEVCSGHTGHTEAVRVVY
                     DPKVVPYTTLLKLFWESHDPTQGFRQGNDVGTQYRSAIYTHSPAQQQAAEASRDAYRTV
                     LRNAGHGDITTEILPATGRPFYPAEGYHQQYLDKNPAGYCGVGGTGVSCPIGVARADG"
     gene            complement(16033..17193)
                     /locus_tag="HEP86_RS25815"
                     /old_locus_tag="HEP86_25815"
     CDS             complement(16033..17193)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089262.1"
                     /locus_tag="HEP86_RS25815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25815"
                     /product="hypothetical protein"
                     /protein_id="WP_168481141.1"
                     /transl_table=11
                     /translation="MDALLVLFAALALGGLVFLPWMRRRRAVQHTRQGLVVASDPMAGY
                     GFVPLEELDVRLPGPDQELADALAEMRRTHDWRPAAELLKSTGDDWERRWQRVQTLAGA
                     AAFELAAEEASEQQLRGAGPGYGDGGRTGGIWLRTWRSEAPKDPGGAQTHAQFLVVQAL
                     RDPGSQDFRMILEEARTVCREAALLAPGSPIPYITELAIARGLHDRPADYEELWSKVAQ
                     RAPQHMGAHLAALPYWSQKWHGSREQAESFAERAASAAPKGTLLPALPLFAVYEHLPEA
                     NMVRSLYQSAVVERAIEGAHFALREAPTDHPMAPHVRHLLVWFLVRAERYAEAMEQLRL
                     VDGHVGAVPWSYGHSPAAEYAAYRALAIAGWEQLGGTSAGFPPSGS"
     misc_feature    17211..17224
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.96"
                     /tool="antismash"
     misc_feature    17319..17337
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.28"
                     /tool="antismash"
     misc_feature    complement(17348..17362)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.62"
                     /tool="antismash"
     gene            17393..18553
                     /locus_tag="HEP86_RS25820"
                     /old_locus_tag="HEP86_25820"
     CDS             17393..18553
                     /EC_number="2.5.1.48"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (60-209). E-value:
                     2.2e-09. Score: 28.8. Matches aSDomain:
                     nrpspksdomains_HEP86_RS25820_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008737495.1"
                     /locus_tag="HEP86_RS25820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25820"
                     /product="cystathionine gamma-synthase"
                     /protein_id="WP_168481142.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.6e-12,
                     bitscore: 46.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3e-07, bitscore:
                     28.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 2e-05, bitscore:
                     22.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDQREERHQHFETRAIHAGQEPDEVTGAVVPPIYQVSTYKQDGV
                     GGLRGGYEYSRSANPTRTALEENLAALDGGRRGLAFASGLAAEDCLLRTLLTPGDHVVI
                     PNDAYGGTFRLISKVVERWGVEWSVADTSDPQAVRAALRPRTKAIWVETPSNPLLGITD
                     IAALAAVARDAGVKLVVDNTFASPYLQQPLALGADVVVYSTTKYMGGHSDVVGGALVVG
                     DDTLGEELAYHQNAMGAVSGPFDAWLVMRGIKTLAVRMDRHSANAERIAELLSSHNKVT
                     QVYYPGLAEHPGHDVATKQMRSYGGMVSFRVAGGEQEAVEVCNRAKLFTLGESLGGVES
                     LIEHPGRMTHASTAGSLLEVPADLVRLSVGIESVDDLLADLTQALG"
     aSDomain        17573..18019
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS25820_Aminotran_1_2.1"
                     /evalue="2.20E-09"
                     /label="HEP86_RS25820_Aminotran_1_2.1"
                     /locus_tag="HEP86_RS25820"
                     /protein_end="209"
                     /protein_start="60"
                     /score="28.8"
                     /tool="antismash"
                     /translation="TRTALEENLAALDGGRRGLAFASGLAAEDCLLRTLLTPGDHVVIP
                     NDAYGGTFRLISKVVERWGVEWSVADTSDPQAVRAALRPRTKAIWVETPSNPLLGITDI
                     AALAAVARDAGVKLVVDNTFASPYLQQPLALGADVVVYSTTKYMG"
     gene            complement(18578..18826)
                     /locus_tag="HEP86_RS25825"
                     /old_locus_tag="HEP86_25825"
     CDS             complement(18578..18826)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981944.1"
                     /locus_tag="HEP86_RS25825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25825"
                     /product="hypothetical protein"
                     /protein_id="WP_168481143.1"
                     /transl_table=11
                     /translation="MSPADRKETEVRRMLAGPHPLVPTDLAARATARGRRLMIHRRRAR
                     HLGRLLALLVLAALVWAAAAQPWLPSPAHTTPRVEGW"
     gene            complement(18823..19353)
                     /locus_tag="HEP86_RS25830"
                     /old_locus_tag="HEP86_25830"
     CDS             complement(18823..19353)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610974.1"
                     /locus_tag="HEP86_RS25830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25830"
                     /product="sigma factor-like helix-turn-helix DNA-binding
                     protein"
                     /protein_id="WP_168481144.1"
                     /transl_table=11
                     /translation="MRERRSEQERRHAREFERFVAGAAGRLLHTATLLTGEPTARPAPA
                     AEELLLRALSRTYADWDRLRGDDPYAHTRQELAALFTHTARRHRRPRGGLLDRLSPQER
                     LVLVLRFHEDVAEEQTAAQLGLPSERVHTLCLHALGELRSRRPGPAPFPAADSAPPTET
                     ETGTGTTPDLTAP"
     gene            complement(19488..19988)
                     /locus_tag="HEP86_RS25835"
                     /old_locus_tag="HEP86_25835"
     CDS             complement(19488..19988)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089264.1"
                     /locus_tag="HEP86_RS25835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_25835"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_168481145.1"
                     /transl_table=11
                     /translation="MPTSSDMTTHTDPALLDALQHQVAVFARRAEQSRLGGVGQARNSM
                     DRAAYLLLNRLDQEGPMGVKALAAGMGIDSSTVTRQVAPLVDSGLVSRATHPEDGRAVV
                     LQLSERGHARLDEVRTSRRALMALVTEQWSEEERTAFTTLLTRFNASLCDITAALPPTG
                     PTS"
     misc_feature    complement(20948..20962)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
ORIGIN
        1 tgatccgctt cagcatcgaa aatgagctca gcggtccgga cgtctactcc aacgcctttg
       61 tcttcatgtc ccttgccatg gttctcaccc gcaccgcggt gctggtggcc aagcgccgcc
      121 gcattcgcct ttcgcccgcg gaaccggccg ggaaggaaga gcagccggcg gcggtctgag
      181 gggcgccccg cgatattcct gcgccgcatg cgaagcggat gtgctcgggg acaacccggg
      241 cacatccgct tcgcggacct cgacgatgga ccaagattga acggaggccg ccggccgcac
      301 gtacagatca cggcggccga atcccggttc cggtccgccg tgccaccacc ggccccgcac
      361 ggaaggacct tcgggttgcc gcactccacg cgcctcagcc agccgccgaa aacgaagaag
      421 gcaaccacga cggaggcccc gccgccggac ggccctccgg agcgggtgcc ggacggggcc
      481 gatgccgacg aggccgctgc cgacaagagc gctgtcgacg aggccgatgt cgacgagagc
      541 gctgccgacg aggccgctgt cgacacgacg tccgagacca gcggctcgac cggggacgac
      601 acggccgtcg gctcgaccgg ggacgacgcg gccgtcggct ggcgggaccg gaatccggcc
      661 gtggcgcggg ccgcggggcg aacggtcacc gcgctggccg ccgtactggt gctctccgcg
      721 ctcctgctgc cgaaccagct cacccggctc acccccggcg agttcctgcg catcccggtg
      781 gagggcatct tcggtgcggc cctgctgctg ctcctgccgc cgaaggcgcg gcgggtggcg
      841 gccgtggtcg ccggcgtcgg cctcggcctg cggaccctcc tgaactgcct ggacatgggc
      901 ttctattcgg tgctcgcccg gcccttcgac ccggtgctcg actggatcct gttcgacgac
      961 gccgagtcgt tcctcaagga ctcgataggt caggcgggcg cgatcggtgc cgtactcggc
     1021 gtcgtgctcc tcgtgctcgc cctgctcgtc ctcatgacgc tggcggtcgt ccggctcacc
     1081 cgcctcctgg tgcggcacag cgccgtggcg acccgtacca ccctcgtcct cggaaccgcc
     1141 tggatcacct gcgcggcgct cggcgtacag ctcgccggtg tcccggtcgc cgccgccaac
     1201 accgccgacc tcgtccagga cagtgcggag cggctgcgcg cgagtctggc cgaccagcag
     1261 gtgttcgcca aggaggcgca cgtcgacgcc ttccgcgaca ccccgcccga ccagctgctg
     1321 accggactgc gcggcaagga cgtcatcttc accttcatcg agagctacgg ccgcagcgcg
     1381 atcgcggatc cggcgatggc ctcgcaggtc gacgaggtgc tcaaggacgg gaccaagcgg
     1441 ctgcgcaagg ccgggttcgc ctcccggagt gcgtggctca cctcaccgac ggcgggcggc
     1501 ggcagctggc ttgcccactc caccttcatg tccggcctct ggatcaagaa ccagcagcgc
     1561 taccgcaccg tcacctccag cgaccggatg cccctcaccg acgccttcaa gcgctccggc
     1621 gcctggcgca ccgccggcat catgccgggc gtcacccgct cctggccgga gggcaagttc
     1681 tacggcctcg accacgtcta cgacacccac catctcggct acaagggccc gcagttcagc
     1741 tggtcgcggg tgcccgacca atacagcctg tcggcctttg aacgcctgga gcacggcaag
     1801 cgccatgaca agccgctgat gtcggagatc atcctcgtct ccagccacaa cccctgggcg
     1861 cccatcccca agatgatcgg ctgggacgaa ctcggcgacg gttccgtcta cgacgccatc
     1921 aagaaggcgg gtaaggaccc caaggaggtg tggaaggacc ccgcacaggt acggaacgag
     1981 taccgccgcg cgatccagta ctcgctgcac agcctcatct cgtacatgga gaagtacggc
     2041 aacaagaaca ccgtgctggt cttcctcggc gaccaccagc ccgtgccgac cgtcaccggc
     2101 gagaacgcca gccgcgatgt gccggtcgcc ctcgtcgccc acgaccccgc cgtgctggac
     2161 cgggtctccg gctggaactg gcagaacggc ctgaagcccg gcccgaagac cccggtttgg
     2221 cggatggaca ccttccgcga ccgcttcctg accgctttcg gcccccggcc gggagagacg
     2281 aagggaggga cgccggagcg gtcggaacac tgacagcaga gtcggcgcac cacctccgcg
     2341 aggccccgct ccgcgcctga cgcccagggc cgctcccccc ccgggagcgg ccctgctccg
     2401 ttcgacagcc atggcacacc gccggagaat tggagaggtg aggaggggca ggccatgact
     2461 atccgcatag ccactttcaa ctgcgaaaac ctcttccggc ggcccatcgt tttcagcgcc
     2521 gggaacgact cggtgcacaa cgccgtgctg gaggacttca gaaaactcgt cggcatcctc
     2581 gatcaccaca cgtatacggc cgacgacaag acaaagatca tcgaccttct caagaagcac
     2641 agcgtcgatg tctcccagga aatctccacc cagacgatcc tgctgaacga gccgcgcgga
     2701 caggcccggc tgctcaaggg cgacggcagg aacatcgagg tcagggccga ggtcacggga
     2761 cggtccgcct gggtcggctg ggccgaactg gtcaagggcg acctcagctg ggacgccgtc
     2821 aagaacaccg ccagggtgat tgccgaggtg aacgccgaca tcctgctgac ggtcgaagtc
     2881 gaggaccggc tcaccctgca ccgcttcaac cgacaggtgc tggcgggcca attcgacgcg
     2941 gaaccctatc cgttcaacat gctgatcgat ggcaatgaca ttcgcggtat cgacgtgggg
     3001 ctgttcagcc ggcacccgat cacctccgta cgctcgcaca tcttcgacat gaaggattcc
     3061 cgggaaatct tcagccggga ctgcccggaa ttcgagatcg atatcgatgg cgaaccgctc
     3121 tggctcctag ggaaccactt caagagcaag ctcggcggcg gaggcgcgga caagcgcaag
     3181 ctccagggcg agcgcgtcgc ccagctctac cgggccgcac tcaagcgctc ggcccatgtc
     3241 gtggtcgccg gggacctcaa cgacaccccg ggcagcccac cgctcacgtt cctggaggcc
     3301 accagcctga aggacgcgat gacccacgac agttacgagg gaccgcccgg cacccacggg
     3361 aagtgcacga gccgcaacga caagatcgac tacctgatgt tctcgccgca gctgttcgcc
     3421 aaggtggaca cggtcgaggt ggagcggcgc gggatcttcg agttcggcac cccgttcgac
     3481 accgtgaccg gccccggcga ccaggcatcc gaccacgctg ccgtcgtcgc cgaactcgac
     3541 ctgtaatccg gcccggcggc acgtcggggc tcgcccgcac acctcagccg tcaggccgtc
     3601 agcccattga tcatgcggtc gagaaggcgg tcgaacacgg cctgcggtgc cgagtcatga
     3661 cccggcaccg ccagggcctg cgcgaggtgg ggatagctgc ccccggcggc aacggaccgg
     3721 aggtagcggt cctgcgcgtc caggagttca ccggaggcgg gcccaccggc ttccaccgcc
     3781 cgctcctggg cgagctcata ggaaacatga ctggccacga agccggtgag caggctgaac
     3841 gtctccagtc gggccggcgc ctccagccct acgggggcga ggacggcgag ggcgtactcc
     3901 agggcggcga gcgcgttcgg gccgagcgtc tgccgggccg agagcgcccc ggggagccac
     3961 ggatggcgcc gcatgatcat gcgctgctcc tgcgcgaact gccgcaggtc ggcccgccag
     4021 ttgccggacg gcgcagtcgg cagcccgtgc tcgccgctca cctggtcgat catcagctcc
     4081 agcagcgtct ccttggtggg gacgtagctg tagagcgaca tcgtgcccgc cccgatccgg
     4141 gccgcgaccg cacgcatggt gaccgcggcg agcccttcgg catcggcgag ggcaatggcc
     4201 gcggtggtga tcgcggcgcg gctgtgggcg ggcggccgcc cccgccgcgg gcgttcggcc
     4261 tgcgaccaga gctgctcggg atccacaccg gcactgcgtc cggctgagcc tgtacggggc
     4321 acggcaacct ctcctcactc ctggcgccat ccaatcaccc ctccgcccac acaccgcacg
     4381 ccgtacggga attcggccgg ccgtcagccc tgcgcgaccg gccggacgac gacctcgctc
     4441 acatcgaccg cggcgggctg ctcgatggcg aacgcgatgg cgcgggcgat cgcgtcgggc
     4501 ggtatggcga tgtcgtcccg catcttcgtg atctccgccc ggacccggct gttgctggac
     4561 gcttcggcga agtcggtggc ggtgacgccg ggcgagacgg tggtcacccg cagcgcatcg
     4621 ccggcctcct ggcgcagccc ttcacagatc gcccggaccg cgaacttggt accggcgtag
     4681 accgccatgg cggggacgac acgaaaggcc gccgtggagg cgacggtgac gaagtgcccg
     4741 gtgccctgcg cacggaagac cggcagcgcg gcggcgatac cgtgcagcac gcccttcacg
     4801 ttgacgtcga ccatccggtc ccactcctcg acgcgcagat catcgagcgg cgagatcgtg
     4861 cccactccgg cgttgctgac caggacatcg agccgcccga aacgctcacc ggccagcgcg
     4921 accagcgcct caagatcctc ccgccgggtc acatcggtac ggagctgcac cgccgcgcca
     4981 cccgcccgct cgatccgctc caccacctcc gccagccgct cggaccgccg cccaccgaga
     5041 accagccgcg caccccgctc cgcgagcaac aacgcggtcg ccgcaccgat accgctgccg
     5101 gctcccgtaa cagccaccac ttttccttca attccagcga ttccagcgat tccagacatg
     5161 gggaatttcc ttccttctcg gggggagagg gggccgggag gggcgccgca gcccgtggca
     5221 cgccgcggcc gaccgccgga gccgtgtcac gccgccatcc gtccagtcgc cgtcagtcgc
     5281 cgtccggcct tcgcccacca ccaccctcca ccacccttag cctggtatcc agaacgtact
     5341 tattctggaa ctgaggctgc tatgccaccg cccccgccat cggaccaacg ccaccaactg
     5401 ggtgcgttcc tgcgcagccg ccgggaacgc ctcactccgg ccgaggtcgg cctgccgcag
     5461 accgcccgtc gccggacgcc gggcctgcgc cgggaggagc tggcgctgct ggccggcatc
     5521 agcgccacct ggtacacgta cctggagcaa ggacgcgaga tccgcgtctc cgaacaggtg
     5581 ctgaccgccc tgtccaccgc actacggctc gaccgccacg agcacgccca cctgctccaa
     5641 ctggccggcc acgctcccgc ggacgcaccc gaggaccgcg aaccgctcac tcccgaggcc
     5701 gcagccgtac cgctcctgct ccagccgcac cccgcgtacc tcatcgacgg cacctacgac
     5761 gtgctcagcc acaaccaggc ggccgaagcg ctcttccccc gtctcatcga caacgcggca
     5821 cagcgcccgc ccaacttcct ccgctggacg ttcctcgaac cggtggcccg cgacatcgtg
     5881 ctcgactggg aaccggaggc ccgcgccctg ctcgcccgtc tccgcaccca gtccgaacgc
     5941 caccccgccg acccgcgcta cccccgcctc atcgacgagc tgaccaccca cagccccgaa
     6001 gcacgcgcct ggtggcccca ctacgaggtc cagccccgcc acagcggcca caaacgcctg
     6061 caccaccccc aacgcggccc ggtcgcatac gcctacacgg ccttccacct ggccgaacac
     6121 ccggaccgga cactggtggt ctacgtcgat gcggcgacgg catccgggca gccgctgccc
     6181 gggttttgag accgtggagt gtcagggccc gtcagggcgc gccgtgaagg cggcggtgca
     6241 gttcccgtac cgctggtgcc tcactccacg ggcgggtttc ctcgctccac gggcagctcg
     6301 gcctcgatga ggtcggcggc ccgctgggtg ccgccctccg cggccatctc ccgctggacg
     6361 gccgcgaggc gccgcgccac ctccgggtcg tcgacgagcg cgagcaccgc cgcacggagg
     6421 gtgccggcgt ccgcctcgtc catcggtaca tggcgggcca cgccgagccc ctgaagcatc
     6481 tccgcgttgc cgaactggtc gacggcctgc ggaacggcca ccatgggcgt gccggtggcc
     6541 aggccctcct gactgccacc cgccccggca tgcgtgatga acgcgtcgga cttcctcaaa
     6601 atcgccaact gaggcacgca ctcccgcact tcgacgttcc cagcaacctc cccgaggtcc
     6661 tcggcggtga catgcttgcc cacctgaagc acgacatgcc agcccggcag ctcgccgaac
     6721 gccttgacgc actcgcggta gaacccgggc ttcttggtgt aggacgagcc gagcgaaacc
     6781 agcaacaccc gctcggcacc cacgggccgc tcccagtccc cctgcgccgc ccgctccccc
     6841 tggcaggccc cgacaaacga gtggaccttc tcatcgaccc gatcggcatg cggctgtagc
     6901 gccttcggga tgagcacgat cgaacgcccg ggccgcccga cgaacggatc gggatgctcc
     6961 gaaatcccgt tctccgtaag ccagttgctg aacctctcgt agtacgcccg cccacgttcg
     7021 gtcgccctcg gctccgccca catcggctcg gcgacctctt cctcgtaccc ctcccacgcc
     7081 acgaggttcg gcgagagcga gaccgccggc accccccagc gatgggcgag cacacgcgcc
     7141 gggtacgagg tgatgtcatg cagcacgaga tccggctcat cacctcgata ggcctcgatg
     7201 agctgcggca gcacctggat cgcgtcgtcg agaaacggct cgacgttgtc gagaagcgtg
     7261 gtcccccacg ctgacgggtc gtcgtcgggc gagggcagcg tagtgcggta caggacaggc
     7321 tcggcaccgg tctcggcaac cttttcctcg aaaaggtgcg ggatcgcgta cgtgacgcgg
     7381 tgcccacggg caacgagctc gcggatcact tcgaggctcg ggttcacgtg cccatgggcg
     7441 gcgatggaga acatggcgat gtgggcaggt tttttgcgtt ccgggttcgt catggccaca
     7501 cggtaggcga gacgaaacgt ctcgtgcaat atgtttccgg tacgtgcctc gtggggtgct
     7561 cgccgggccg ttcatcgaac ggctccagcc cgagccgctc ggagtggaac cgccgtaacc
     7621 gctccagatc ctgggccgga agcctggtcg ccacccgcgc cagagaggaa gcggcgaagg
     7681 ctctgccggg acccgcctgt gccgcgcgtt cagtgaccgg cgtgggccga gcggaggacc
     7741 gccttcgctt gcccggccgg cgcggtctgc cgggtggggc gtctagcgga agatccggaa
     7801 attactacca tgcgcacgat caggccaccg ccgggtcggt ccgacgatct tccctggaag
     7861 ggcgggaaca cactccgctg caagagctcc gttcacatct gggagggaac ggtgtcgcag
     7921 tcccgcaggt tctcgagtcg tctcactggc tggtttccat cggccgccca ctacactgcg
     7981 tggcccgtcc tgttgagcac ggtcggctcc tcaaggggga gtggttcgca ccgcggcagg
     8041 gagatccagt gaaagacgtc gggtcggtgc gtactgtcgt ataccgggag gatgagccca
     8101 atcctggcga cttccaggcc agtgcgagca tcgtgcaggc gggtttcttc tgctgggaga
     8161 tcgccactgg cgaggtgagc tgcgatccgc tcaccctcgc gctgcatggc atgcccgaga
     8221 gcggcccgtc gggcatctcg agcttcctgg cctcagtgca cgagtccgat ctggccgatg
     8281 tgcgggatgc cttggggctg atatcggaat cctgcggcaa ctaccagatc gagtaccgcg
     8341 tcacctccga cgacggccgg caccggtccc tggaagcccg gggccgcgtc ctgcccggcg
     8401 ctgacgggct gccggcccgc atggtcggag tggtcatgga caccacggcc gtccatgagc
     8461 gccacgaggc ggagaggcgg cggctgtacg agcgcgcgag ccgtgaccgc tggatgcagg
     8521 agctgactgc ggctctggcc gccgcagtga cggtcaagga catcatgacc gctgcacagg
     8581 cgggactgcg taccttcgga gcggatgcgc tggcggtgat cgccccggag gaggaccggt
     8641 tgaccgtcgt cgcctcgtgc gccgacgacg agcagggcga ggactccata ggagtcctcg
     8701 acgccacggc ccgcacgctc gtgaaggagt cactcgaccg tagggcgccc gtcctcatcg
     8761 gctccgagga cgcgctgcgc accagctatc cgcacctggc accgctcgcg ccgtcggccc
     8821 ggcaggcgtg ggcggcactg ccgctcacgg actcgcgcgg ccgcgtcagt tcctgcctcg
     8881 tcagtttccc cgagccgcag gaattcctgc tcgaggagcg ggccctcctg gtcgccgcca
     8941 tgggactgct cgcccagtca ctggagcgag ccggcatgta cgagtcggaa cacgcgctcg
     9001 cgaccgagct ccaacgtggc atgctgccgc gcgggccgct cacggtgccg ggtgtcacca
     9061 tcgccgcccg ctaccaggcc gccacctccg gcatgtggat cggtggcgac tggtacgacg
     9121 ccatcagcct gcccgacggc ggcgtggcgc tggtcatcgg agatgtgcag ggacacagcg
     9181 tgcacgccgc gtccctcatg gggcggctgc gcaccgccgt gcacgcctac gcgaacgaag
     9241 gacacccgcc cgcggccgtc ctggaacgca ccaaccgcct gctgaccgag ctgaacaccg
     9301 acccggaccg ggccctgttc gccacgtgct gctacctcgc actcaccccg tccgacggaa
     9361 cgctccgggt gtgccgggcg ggccatccgc ccccagcgct gatcacgccc cgcaagccgc
     9421 cgcgcctcct ggaggtcccc ggcggcctcc ctctggggat cgaccgggag cagcggtacc
     9481 cgaccacccg cctgcgcatc gctccgggca gtgtgctcgc gctgaccacc gacggcctgc
     9541 tcgaggccgt gaacaaggac atcgaccagg gcttcgagag gtttctccag ggtctgcgag
     9601 gggctcccac ggcggacctg gagactgttg tcgacaacct ccttgccggt acgcagaagg
     9661 ctcacggcct gggcgacgac gtcgctgtgc tcctggctcg tctgaacagg cccggtcgcc
     9721 gcaactgacc cgggcctgac ctggcctgtc ctcaaccagc ttggatcgcc gggtacttgt
     9781 ctccacgacc aaccgaattt cccggtctgt ggtgctgccc ggcgcaaggc aaagagcacc
     9841 aaagaaacca ggccccggtc aaagatcatt gacgggcagg gtaatttaca tcggtggttg
     9901 ggattgcctg gtcatgctcc atgcgggcct tggcgtgctg catcggcaat gtcgctggat
     9961 gtcgcgaacg gcagagaatt atcgaaaagt gagctgacgt atggaaaatt tccggatccc
    10021 ggccctttac gtacccgtac cggcagcgct caatccggaa ctccaggagg tcacggcggc
    10081 cgctgaggcg tggttggacg agttcggtct ggtgccgacc gaggaggcgc gtcggcatgt
    10141 gcagcgcact cgtgtggacc ggctcaccgc gtggctgtgc ccgaacgcct cacgggaggc
    10201 gctgacgctg atcacccagt ggaacgggtg gctgttccag ttggacgacc agttcgacga
    10261 cgacccggtg cgcggttacc ggtccgagca gtggcgggag gcgttcgggc cgttgttcgc
    10321 cgtattcgac ggaaacgtta cggctgggcc actggcgcgt tccttggccg atctgtggcg
    10381 ccgcacgacg gctgtccgtt cttccgcatg gcagcgcaga ttcatcccgc acctgttgtg
    10441 gtatttcgaa agctaccggg ccgatatgat tcatcgggag gaagggcgaa tacccggcct
    10501 ccagcaatat ctcgcccacc gccgcgcctc attcgcattc gacgccgtcc tggacctgat
    10561 ggaaatcggt accggtgtgg acctgcccga ccaactgcat gcgaacccgg ccttcgcgga
    10621 catgcgagag gcagtgatct atgcgaatgc ctgcatcaac gatctctact cgctgcccaa
    10681 agaactcgcc catgactatg cgttcaacgc cgtcacggtg atctgccacc atcaccggtg
    10741 cagcctccag gaggcggtgg agcgcgtggc cgtgatgcag gccggatacg tccagcgcat
    10801 cctcgatctt gaacgggtcc tgcccgcgcg gctggagcgt tccggccttg ccgacgacgt
    10861 catcgccgac gcgctccgct gtgtcaggga cttccacgcg ctcaccgccg ggaacgtcgc
    10921 ttggtcgaag gagaccgggc gctatgcgga gatagaggcc aaaccgacct atctggcgga
    10981 cttgttcatt ccgtaggacc cgtcggccgt cgcccaagcg tgtcagggcg cacgacctgt
    11041 cattccccgg tcggtgccgg gcgagccctg tggggcatga ggcccccggt acgtcccgaa
    11101 cggggtactc agcttgacgc ccgtccctcc gatccctcag tacctcgccg ggttttggtc
    11161 gaggtactgc tggtggcggc ggctgcgtgt cgatgttgtg gtccgggacc taccaggccc
    11221 gcggccccct gccacccaca gggcgtgcgt cgggcccgtg cggtccggcc ggaaacacgg
    11281 ctgctctgac gctgcggtgc cggcggcaac ccgagcgaat ccagtcgtgg ccccttaccc
    11341 ttgacgtggg gcacaggtca acctcgccgg gtgatggaga tgctcgacct ttcctccgcg
    11401 ctgtccgatg tcccgcctct acggggccag gcgccatggc cccatcacga atacgtcaag
    11461 ggttggggtg tcttcggact gcctttcgca tccggtcacg tcctcgccct gcgcgtcttt
    11521 ccggagaact gcttcagtcc ctaccgcacg ctgtggcatc gcgacccgaa cggcagttgg
    11581 tcgatttacg tcgacgggcc acgactggac accgcatgcc ccaggtatta cggcgctgcc
    11641 tgcgcccaca ccgggtatgc ccggatcggg ctcacgtgga cgggccctgc caccttgcgg
    11701 gtgacgatgg attccccctc cctggactgg accctcactg cctccgcgac acgattcctt
    11761 ggcctcctca acggcatcag tggggcgctg ccgctcgcca cttggcgctc tcgactcctg
    11821 gtgcgggccc gcgagcgcct ggctcgtgcg ctgggaatgg gggaccttca gctctccggc
    11881 acgatgccga gcggtcacac cggaacgctc atgccacagc ggatgtactt cgtcgacgat
    11941 tcgagtgcca cattcgaggg cgtcgacctc gggcgcccgg tccagctgac ggagaacccg
    12001 cgcatcggtg acgtgcccct gccggcccgt ggggttctgg ccatcggcca ggcggcatgg
    12061 gagattctcg acccggcgga atacgaacgc acgcgtaccg agaccgcccg ggatctctcc
    12121 ctcccgggag agggcggtcc cgaggggcga aaagctgatt gagccccgca ctgcgtagat
    12181 acggaagggc cctctctgag gccggcatcg cagttgcact tgggtcagcc gttgtcaggg
    12241 gtgctgatga cgacaagcgg cacgactgtc gccgcccaga aggccacgac cagaacgctg
    12301 aatagtcgct gtctcacagg cactcaccgc ccgttggcgt cacgcgccag aaccgcgtga
    12361 cggtctcgcg gtacccgcgg tgcgaggggt gttggccggt atgcgagaag gcccagtctc
    12421 gtgcggtctt gaattcttcc gagggatctg ctgcggcgtc gcaggacatg cactccaact
    12481 cgtgcaccat ctccggggct tccggagcgg tctccggtcc catcgtccat ctgaggtagc
    12541 ggaagacgga cctggtcaca gtccactcct gctgtgagcg ttgagttctg ccactcgtga
    12601 gctcagatcg tcacgggaac cgagtgcgcg taggtcctgc ggacgtgcgt cccattcgat
    12661 cccgccttgg ggcggacgca gttgtacgtg cgaccacatg acgtccatga cccggccgac
    12721 ccggccgctc ctggtgtcca gcgtcaaagt gcccaccgca ggggctttct tgtcgctcat
    12781 gcaaggagga tcacggcgac gcccaggacg taggaacctc gcccaaaacc cattttggga
    12841 cgtcccagag gaggtagaac gtccctagca acgtcccaac ttccagggag agactgcgga
    12901 tgccgaacga gaggcttcga gccgccatgg cagccggagg gtggacccat gccaccctcg
    12961 cagccagggc ccaggtggac cccaagtccg ttgagcggtg ggtcaacttg ggtcggaccc
    13021 cgcgacgggc gacggccctg ctggcggctg agacgttagg agaagacgtg catgcacttt
    13081 ggccggcgct caggcaagca cgctctgccc gcgctgtcag ctccgagctg gtcgcgttgt
    13141 acgaccagcg cgcggacgtt cccgtttcca cgttcacgga catgctggcg gagggccgcg
    13201 agaacatcga cgtactcgtc tacgcggcgg tcttcctgca cgaggggttt ccccgcctga
    13261 acgatctgct ccgcgagcgc gccgccgaag ggtgctctgt ccgcatcgcg ttgggtgatg
    13321 cggagagcga aaacgtgcgg cagcgcggcg aggaggaacg gttcgggcac ggcatcgaat
    13381 cgcgttgccg gctggccctc atgcactacc ggccgctcct cggggtaccc ggagtcgaga
    13441 tccggaccca cggaaccacg ctgtacaact ccatctaccg ggcggacgat cagctcctgg
    13501 ccaatgccca tgtctggggc gtgaacgcct atggagcacc ggtatggcac cttcgtcgca
    13561 acggggatgg tggcatcttc gacacctatg cccagagctt cgacgcggtc tggacgacgg
    13621 cgaagcctgt acccgaggag tgaaccctgt cgcgcaccga gtattacgac gatcccgatg
    13681 cccccgagcc caacagtctc gtcgttgccg cttcagccgt ggtgcccgac gacgagggcc
    13741 gcatcctgct ccagcggcgc cgggacaacg acctctgggc cctgcccggc ggcggcatgg
    13801 agatgaccga ctcccttccc ggcaccgcgg tccgggaggt caaggaggag accgggctgg
    13861 atgtggagat cacggggctg gtggggacgt acaccgatcc ccgtcatgtg atcgcctata
    13921 ccgacgggga ggtgcggcgg cagttcaacg tgtgctttac cgcgcgtgtc gtcggggggc
    13981 agcttgccat ctcggatgag tcgacggagc tgcggttcat ccaccccgat gagatcggcg
    14041 atctcccgat gcaccacacg caggagctgc gtattcgaca cttcctggag cgtcgggagc
    14101 gcccctacct ggggtgacga ctccgaggtc agtccctggc cggagccatg cccacctggc
    14161 agctcacgct cgtccctaac gggttgtgtt ggcccgtgat tggctcgccc ggtcagtgga
    14221 tgacgacgcc tgggacaagg gcggcgaggc cggagacaaa gctccctacg cctgcgagcg
    14281 tgacgatgat ggccttgccg tccgagaaca ggcccgagca gaaggcgcgt agctggcgtc
    14341 ggaggaccaa caccttgagt ttctcccagc ggtgctggcg gacctgcgga catcccatga
    14401 gaagtcccga agcattgttc cggcagccgt catctctccc tcggaccgga gcaccacacg
    14461 taacaggggc tcggaagaag caccacgcgg tagtgactgc tgagagcacg atcaccacga
    14521 ctggtcctgc cgcatggttg atccacgcgg cgatcagcag aaggccactt aggacccccc
    14581 accacttgcc cagaccacca agcccttttc ctgctgcccc cgaggttgcc atagcctgca
    14641 ttttggtggg tctgctcccg ccgtctgtac ggtgctgccc ctccttggct agaaagcggc
    14701 gcaggtaggc ggatgcgtgc tggttgcggg atttgcctgg ctatgtcatc cgtgccaagc
    14761 ggggcgttag tccgtacgcc ctgttccggc cgagattccc aaggccagtc ctcgacgggc
    14821 gcgaccccgt cggacacggg ccccagccgc cttcagaaag atactgctgg tgcgtgccct
    14881 cacttgctca tcgttcgatg aagcgggggt ccgtccatgc ggtgatcggt tggtcggcga
    14941 ctgagtagat ctccagggcg gaaaggtagc cgccctcggt gcagaccatg acgccggccg
    15001 agtacggggc gtcgtaccag gcatccacgg ccggattgtc atgcgacggc gcaggagccg
    15061 ccgccgtacg gtccacttcc agatcgaccg tcacgcagcc gcagccacac ctgcccacca
    15121 cccgtgtgtg gggaagctgg gccagcaggg cgttgctcac cggatccgag ccggccagca
    15181 gcgcctgcag cgtcgccgtg gcttccggcg acagttgctc agccatccgc ccttgccacg
    15241 ccgatcgggc aagagacgcc cgtcccgccg acgccgcagt acccggccgg gttcttgtcc
    15301 aagtactgct ggtggtagcc ctccgccggg tagaacgggc ggccggtggc ggggaggatt
    15361 tcggtggtga tgtcgccgtg gccggcgttg cgcaggacgg tgcggtaggc gtcgcgggag
    15421 gcttcggcgg cctgttgctg ggcgggggag tgggtgtaga tggcggagcg gtattgggtg
    15481 cctacgtcgt tgccctggcg gaagccctgg gtggggtcgt gggactccca gaagagcttc
    15541 aggagggtcg tgtacgggac gaccttgggg tcgtagacga cgcggacggc ctcggtgtgg
    15601 ccggtgtggc cgctacagac ctcttcgtag gtggggttcg gggtgtggcc gccctggtag
    15661 ccgaccaggg tggtccagac gccctcggtc tgccagaact tccgctcggc gccccagaag
    15721 cagcccagcc cgaagtcggc gatctccagg ccgtccgggt acgggccgag cagcgggttg
    15781 ccgaggacgg tgtgccggtc ggggacggcg aaggcccgct cggggcggcc ttccagcgcc
    15841 tcctccgggg tggggagctg gttcttgaag cgggagaaca gcacggggat cagctcctga
    15901 gggtgaggaa gggaaggggg gcgacctggc gggcgctggg gcgggggcgg tgtgcgtacg
    15961 gctgcactgg gaggaacgcc cgcagggcaa taggcattcc ggcctccgaa ctcagttccc
    16021 gggtgtccga actcagctcc cggatggcgg aaaccccgca gaggtccccc cgagctgttc
    16081 ccagccggcg atggccaggg cgcggtaggc ggcgtattcg gcggcggggc tgtggccgta
    16141 ggaccagggg acggcgccta cgtggccgtc gacgaggcgg agctgttcca tggcttcggc
    16201 gtagcgctcg gcgcgtacca ggaaccagac caggagatgg cggacgtggg gggccatggg
    16261 gtggtcggtg ggggcctcgc ggagggcgaa gtgggcgccc tcgatggcgc gctcgacgac
    16321 cgcgctctga tagaggctgc ggaccatgtt ggcctcgggg aggtgctcgt agaccgcgaa
    16381 gagggggagg gccgggagga gggtcccctt gggggcggcg gacgcggcgc gctcggcgaa
    16441 ggactcggcc tgttcgcggg agccgtgcca cttctgcgac cagtagggga gcgcggcgag
    16501 gtgggcgccc atgtgctgcg gggcgcgctg ggcgaccttg gaccagagct cctcgtagtc
    16561 ggcggggcgg tcgtgcagtc cgcgggcgat cgccagctcg gtgatgtacg ggatcgggct
    16621 gccgggggcc agcagcgccg cttcccggca gaccgtacgg gcctcttcca gaatcatccg
    16681 gaagtcctgg gagcccgggt cgcgcagcgc ctggacgacg aggaactggg cgtgcgtctg
    16741 agcgccgccg gggtccttgg gggcttccga gcgccaggtg cgcagccaga tcccgccggt
    16801 ccggccgccg tcgccgtacc ccgggcccgc accgcgcagc tgctgctccg aggcctcctc
    16861 ggcggccagc tcgaaggccg cggcaccggc cagcgtctgc acccgctgcc agcggcgctc
    16921 ccagtcgtcg ccggtggact tcagcagctc ggcggccggg cgccagtcgt gcgtgcggcg
    16981 catctcggcg agcgcgtcgg ccagttcctg gtccgggccg ggcaggcgga cgtcgagttc
    17041 ctccagcggt acgaagccgt agcccgccat cgggtcggag gccaccacca ggccctgccg
    17101 ggtgtgctgc acggcccgtc ggcgccgcat ccagggcagg aagacgaggc cgccgagcgc
    17161 gagcgcggcg aagagaacca gcagagcgtc catgtggggt gtcctgtacc tgaaattctt
    17221 gtaacggctg cctgggacct gcggtgcggc ggagacgtgg gcgacgggtg cgaggggcgg
    17281 tgtgcggcgg gcggcggggg aaccgctgtg cggatcctcg tatgtatcca ctatccagcc
    17341 aaccagaaag ttccggaaag ttcggttgcg cggacgacta ccctcggcag gcatgagcga
    17401 tcagcgcgaa gagcgccacc agcatttcga aacccgtgcc atccacgcag gtcaggagcc
    17461 tgacgaggtg accggtgcgg tagtacctcc catctaccag gtatccacgt acaagcagga
    17521 cggcgtgggc gggctccgcg gcggctacga gtacagccgc agcgccaacc cgacccgtac
    17581 cgcccttgaa gagaacctcg cagccctgga cggcggccgc cgcggcctcg ccttcgcctc
    17641 cggcctcgcc gccgaggact gcctgctgcg gaccctgctg acccccggcg accatgtcgt
    17701 catccccaat gacgcctacg gcggcacgtt ccgtctcatc tccaaggtcg tcgagcgctg
    17761 gggcgtggag tggtcggtgg ccgacacctc cgacccgcag gccgtgcgcg ccgcactgcg
    17821 gccccgtacg aaggcgatct gggtggagac gcccagcaac ccgctgctgg gcatcaccga
    17881 catcgcggcg ctcgccgccg tcgcccggga cgccggggtc aagctcgtcg tcgacaacac
    17941 cttcgcgagc ccctacctcc agcagccgct cgccctcggc gccgatgtgg tggtctactc
    18001 cacgaccaag tacatgggcg ggcactcgga cgtcgtcggc ggcgccctgg tcgtcggcga
    18061 cgacaccctc ggtgaggaac tcgcctacca ccagaacgcg atgggcgcgg tctccggccc
    18121 gttcgacgcc tggctggtga tgcgcggcat caagacgctc gccgtccgta tggaccggca
    18181 cagcgccaac gcggagcgca tcgcggagct gctgagcagc cacaacaagg tgacccaggt
    18241 ctactacccc gggctggccg agcacccggg ccacgacgtg gccaccaagc agatgcggtc
    18301 ctacggcggc atggtgtcgt tccgggtcgc gggcggcgag caggaagccg tggaggtctg
    18361 caaccgggcc aagctgttca ccctcggtga gtcgctgggc ggcgtcgagt cgctgatcga
    18421 gcacccgggg cggatgacgc acgcctcgac ggccgggtcg ctcctggagg tccccgccga
    18481 cctcgtgcgc ctctcggtcg gcatcgagtc cgtcgacgac ctgctggccg acctcacgca
    18541 ggcgctgggc tgacgggaca ctcgccggct ccgccgttca ccacccctcc acgcgagggg
    18601 tggtgtgggc cggcgagggc agccacggct gggccgcggc cgcccagacc agggccgcca
    18661 gcaccaggag cgcgagcagc cggccgaggt gccgcgcccg cctgcggtgg atcatcaggc
    18721 ggcggccgcg ggcggtggcg cgcgcggcca gatcggtggg gacgagcgga tgcggcccgg
    18781 ccagcatccg ccgtacctcg gtctccttgc ggtcggcggg actcatgggg ccgtgaggtc
    18841 cggtgtggtt cccgttcccg tttccgtttc cgttggcggt gcggagtccg ctgccgggaa
    18901 cggggccggt ccggggcggc ggctgcgcag ctccccgagg gcgtgcagac acagcgtgtg
    18961 cacccgctcg gagggcaggc ccagttgggc cgcggtctgc tcctcggcca cgtcctcgtg
    19021 aaaccgcagc acgaggacca gccgctcctg cggggacagc cggtccagca gcccgccgcg
    19081 cggccggcgg tggcgccggg cggtgtgtgt gaagagggcg gccagctcct ggcgggtgtg
    19141 cgcgtacgga tcgtcgccgc gcagccggtc ccagtcggcg tacgtccgcg acagcgcccg
    19201 gagcagcaac tcctcggcgg ccggggcggg ccgggcggtg ggctcgccgg tcagcagggt
    19261 ggcggtgtgc agcagccggc ccgccgcgcc cgccacgaac cgctcgaact cccgggcgtg
    19321 gcggcgctcc tgctccgacc gccgctctcg caccgcgcct cccggatgac ggacgcacga
    19381 cctcctgggc tcctatagca cgccagtacg gtcggccggt caagaggcgg gacgggcccg
    19441 cggcgcgaga tccgggcccg tgtcaggtca gccggtgtgc gcgggcgtca ggacgtcggg
    19501 cccgtcggcg gcaaggccgc ggtgatgtcg cagagggagg cgttgaagcg cgtcaggagt
    19561 gtggtgaagg cggtgcgctc ctcctcggac cactgctccg tcaccagggc catcagcgca
    19621 cggcgcgagg tgcgcacctc gtccagccgg gcgtgcccgc gctcggacag ctggagcacc
    19681 acggcgcggc cgtcctcggg gtgggtggcg cggctgacca ggccggagtc gaccagcggg
    19741 gcgacctgcc gggtgaccgt cgaggagtcg atgcccatac cggcggcgag ggccttgacg
    19801 cccatcgggc cttcctggtc caggcggttg agcagcagat acgcggcgcg gtccatggag
    19861 ttgcgcgcct gtccgacgcc gccgagccgg ctctgttctg cacggcgggc gaagacggcc
    19921 acttggtgct gtagcgcgtc gaggagagcg gggtcggtgt gggtcgtcat gtccgaagag
    19981 gtgggcatgg ccggaagctc gcttcggtgg aagtgcgtat ggatgagagg acagcgtacg
    20041 cggaccccgc gcggagcgta cctgtgctgc cccttccgat aacgccccgt aaccccgggc
    20101 ggtcgtacgg gacgccgtcc tgcccagccc gccgcgcgcc tgatcaccat tcgggcagaa
    20161 aaggccctcc cgtgggcgaa ctgcgagact ggcgacatgg ccgaccacac gccgcgtacg
    20221 ccgcctgaga ccgccgccgc cgcgctgccc gcgcagggtc cggcggccgc gatcacggtc
    20281 gatgacatcc gggcggcgca caagatgctc tccggtgtct cccgggccac cgcgatggag
    20341 ggcagccgct atctgtccgg gctggtcggc gcgcccgtgc acctgaagtg cgagaacctc
    20401 cagcgcaccg gctccttcaa gatccgtggc gcgtacgtac ggatcgccgg gctctcggcg
    20461 caggagcggg cggccggtgt ggtggccgcg agcgccggca atcacgccca gggggtggcg
    20521 ctggcggcgt ccctgctggg ggtgcgctcg acggtgttca tgccggtcgg cgccccgttg
    20581 ccgaaggtgg ccgcgacccg tgaatacggg gcggaggtac ggctccaggg ccatgtggtg
    20641 gacgagacgc tggccgccgc ccaggagcac gcgcgcgcga ccggtgcggt cttcatccac
    20701 cccttcgacc accacgacat catcgccggg cagggcacgg tcgggctgga gatcctcgaa
    20761 cagtgcccgg aggtacggac catcgtcgtc ggggtcggcg gcggcgggct ggtggccggg
    20821 atcgcgctcg cggtgaagga gctgcggccg gatgtgcggg tcgtcggggt gcaggcggcg
    20881 ggcgcggcct gctatccgcc gtcgctggcg gccgggcgtc cggtggcgat cgaggggctg
    20941 tcgacgatgg ccgacggcat caaggtcggg cggcccggcg aggtgacctt cgggat
//
