LOCUS       NZ_CP050976            22235 bp    DNA     linear   CON 06-JUN-2024
DEFINITION  Streptomyces sp. RPA4-5 chromosome.
ACCESSION   NZ_CP050976
VERSION     NZ_CP050976.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RPA4-5
  ORGANISM  Streptomyces sp. RPA4-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9051652)
  AUTHORS   Nicault,M., Bontemps,C., Tidjani,R., Gelhaye,E. and Leblond,P.
  TITLE     Mining the biosynthetic potential for specialized metabolism of a
            Streptomyces soil community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9051652)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72x/76x
            Sequencing Technology :: Oxford Nanopore GridION/Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012273495.1-RS_2024_06_06
            Annotation Date                   :: 06/06/2024 02:35:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,979
            CDSs (total)                      :: 7,887
            Genes (coding)                    :: 7,432
            CDSs (with protein)               :: 7,432
            Genes (RNA)                       :: 92
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 455
            CDSs (without protein)            :: 455
            Pseudo Genes (ambiguous residues) :: 0 of 455
            Pseudo Genes (frameshifted)       :: 276 of 455
            Pseudo Genes (incomplete)         :: 232 of 455
            Pseudo Genes (internal stop)      :: 23 of 455
            Pseudo Genes (multiple problems)  :: 71 of 455
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:36:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4889542
            Orig. end                         :: 4911777
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050976.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22235
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="18"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22235
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22235
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12235](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12235
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(101..1657)
                     /locus_tag="HEP86_RS21925"
                     /old_locus_tag="HEP86_21925"
     CDS             complement(101..1657)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089881.1"
                     /locus_tag="HEP86_RS21925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21925"
                     /product="IPT/TIG domain-containing protein"
                     /protein_id="WP_168480585.1"
                     /transl_table=11
                     /translation="MSTQVQSPMLELLLQTAALPSQAAQVSPVAASAQVFLAVTSIPVG
                     NNPVGLAIAPSSDLYVANSGSANVSAINTTTDTVIGGPIGVGGTPVWLTVAPNGNAYVP
                     NSGSNTVSVINTATNTVVGAPIAVGNQPAVVAAVPGGRVYVTNFAANTVTVIDTTTNTV
                     IGAPIAVGAQPVGVAVASNGNAYVTNRGSNTVTVINTATNTVIGAPIPVGAQPNFVAIA
                     PNGNAYVANIGSNTVTVINTISNTVVGAPIAVGNQPWGIAVGADGMAYTSNRAANSVTV
                     FDTATNTVVGAPIPVGAGPIAVTVAPNNKVYVSNINGNNVSVIQFDPTLTSIVPTQGPI
                     AGGTVVTITGTNLTGASVDFGGIPATGVSVNAAGTQITATTPPGAAAGPVTVTVTTPGG
                     SASLVNGFTYLLPVHATSLVATPALSKLFPPHVYFPFLTATLTDQVTGLPVPGQTILFK
                     IGSNLVGIATTDAQGVARFNETLILTLILANGGYDAEFVGGSTGSAILSPSSDHAGVIE
                     P"
     gene            complement(1926..2384)
                     /locus_tag="HEP86_RS21930"
                     /old_locus_tag="HEP86_21930"
     CDS             complement(1926..2384)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089882.1"
                     /locus_tag="HEP86_RS21930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21930"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_168480586.1"
                     /transl_table=11
                     /translation="MAPRPPFPPFDEQSAQQKVQAAEDAWNTRDPERVALAYTEDSVWR
                     NRDTFVTGRAEIVDFLRRKWTRELDYALRKELWSYSGNRIAVRFQYESHDAAGQWWRSY
                     GNELWEFDENGLMRRREAGIHDVAITGDERRIFGPRPEEERGHPLPFR"
     misc_feature    2411..2424
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.95"
                     /tool="antismash"
     misc_feature    2437..2455
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.13"
                     /tool="antismash"
     misc_feature    2445..2458
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.02"
                     /tool="antismash"
     gene            2481..3080
                     /locus_tag="HEP86_RS21935"
                     /old_locus_tag="HEP86_21935"
     CDS             2481..3080
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986370.1"
                     /locus_tag="HEP86_RS21935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21935"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_168480587.1"
                     /transl_table=11
                     /translation="MDLDEARTRILDAAEKLFYDRGIQAVGMDELRTAAGVSLKRLYQC
                     FPAKHDLVEAYLRRRDTRWRTALAEYVDAHADGPADRPLAVFDWLGDWFAEDGFRGCAF
                     INAYGELGATSGRVGCVAREHKEALRGYVAGLVRALPVAEPEVLAGQLALLIDGAIAGA
                     ALLGEPSAARQARTAAAALLEAAGSVAGPGAARNGT"
     misc_feature    complement(3081..3096)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.62"
                     /tool="antismash"
     gene            3207..3611
                     /locus_tag="HEP86_RS21940"
                     /old_locus_tag="HEP86_21940"
     CDS             3207..3611
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS21940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_21940"
                     /product="hypothetical protein"
                     /protein_id="WP_168480588.1"
                     /transl_table=11
                     /translation="MTRSKLLRALTVAGTIALSAVATTPAAHAAASSCTHDWSGPQICI
                     ETDGQDGTPQPGTVTATWTNPSKSRQSATVYLTTTDGGSNYSFKAKRSGDQIVGHTAPG
                     IQPSGSTLCVRFKGSSHKACLEMINRNGSF"
     gene            complement(3683..4918)
                     /gene="rocD"
                     /locus_tag="HEP86_RS21945"
                     /old_locus_tag="HEP86_21945"
     CDS             complement(3683..4918)
                     /EC_number="2.6.1.13"
                     /GO_function="GO:0004587 - ornithine aminotransferase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (37-358). E-value: 9.6e-102.
                     Score: 332.4. Matches aSDomain:
                     nrpspksdomains_HEP86_RS21945_Aminotran_3.1"
                     /codon_start=1
                     /gene="rocD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089890.1"
                     /locus_tag="HEP86_RS21945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21945"
                     /product="ornithine--oxo-acid transaminase"
                     /protein_id="WP_168480589.1"
                     /sec_met_domain="Aminotran_3 (E-value: 8.6e-116, bitscore:
                     385.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTRTAQVGAPRSSAELIQAESPVLAHNYHPLPVVVARAEGVW
                     VEDVEGRRYLDMLAGYSALNFGHRHPALVEAAHRQLDQLTLTSRAFHNDRLAGFAEGLA
                     ELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPADRATIVVAGGNFHGRTTTIVGF
                     SDDDTARVGFGPFAPGFRTVPYNDLAALEAALDETTAAVLIEPIQGEAGVLIPDDGYLT
                     GVRELTRRNGCLFIADEIQSGLGRTGTTLAVEHESVVPDMLLLGKALGGGIVPVSAVVA
                     RRDVLGVIGPGQHGSTFGGNPLAAAVGSAVIELLATGEFQRRATELGAVLRDGLAALTG
                     KGVTGFRARGLWAGVDIDPALGTGREISERLLKEGVLVKDTHGSTIRLAPPLTITAEEL
                     TSALGSLERALG"
     aSDomain        complement(3845..4807)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS21945_Aminotran_3.1"
                     /evalue="9.60E-102"
                     /label="HEP86_RS21945_Aminotran_3.1"
                     /locus_tag="HEP86_RS21945"
                     /protein_end="358"
                     /protein_start="37"
                     /score="332.4"
                     /tool="antismash"
                     /translation="VARAEGVWVEDVEGRRYLDMLAGYSALNFGHRHPALVEAAHRQLD
                     QLTLTSRAFHNDRLAGFAEGLAELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPA
                     DRATIVVAGGNFHGRTTTIVGFSDDDTARVGFGPFAPGFRTVPYNDLAALEAALDETTA
                     AVLIEPIQGEAGVLIPDDGYLTGVRELTRRNGCLFIADEIQSGLGRTGTTLAVEHESVV
                     PDMLLLGKALGGGIVPVSAVVARRDVLGVIGPGQHGSTFGGNPLAAAVGSAVIELLATG
                     EFQRRATELGAVLRDGLAALTGKGVTGFRARGLWAGVDID"
     gene            complement(4915..5739)
                     /gene="ddaH"
                     /locus_tag="HEP86_RS21950"
                     /old_locus_tag="HEP86_21950"
     CDS             complement(4915..5739)
                     /EC_number="3.5.3.18"
                     /GO_function="GO:0016403 - dimethylargininase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ddaH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144220.1"
                     /locus_tag="HEP86_RS21950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21950"
                     /product="dimethylargininase"
                     /protein_id="WP_168480590.1"
                     /transl_table=11
                     /translation="MSRESRPRRYLVCEPRHFAVHYAINPWMRADVPVDTALAGRQWEA
                     LMGTYRAHGHTVESVPPVPGLPDMVFAANSALVVGGRVFGSHFHAPQRRPESTEYETWF
                     KAAGYDVYRPESACEGEGDLVPAGRFILAGTGFRTTPAAHREVQEFFGVPTIGLQLVDP
                     YFYHLDTALFVLGESPETGEAHIAYYPEAFSSGSREVLRRLFPDAVLATREDAMAFGLN
                     SVSDGRHVFVAPQASGLIAQLLAHGYVPVPVDLSEFHKAGGGIKCCTQEIRS"
     misc_feature    complement(5791..5804)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.54"
                     /tool="antismash"
     gene            complement(5995..6489)
                     /locus_tag="HEP86_RS21955"
                     /old_locus_tag="HEP86_21955"
     CDS             complement(5995..6489)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089892.1"
                     /locus_tag="HEP86_RS21955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21955"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_168480591.1"
                     /transl_table=11
                     /translation="MTHKAVPFDDLDRKIVAALIDNGRASFAEIGAAIGLSSTAVKRRV
                     DRMRENNVITGFTATVRPAALGWLTEAYVEVYCDSAAPPRRLAEVVRNHPEIAAAMTVT
                     GGADALLHVRATDVEHFEEVLERIRAEPFIRKTISYMVLSHLLPDSPEAGARQPSGGTV
                     G"
     gene            complement(6554..7027)
                     /locus_tag="HEP86_RS21960"
                     /old_locus_tag="HEP86_21960"
     CDS             complement(6554..7027)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088658.1"
                     /locus_tag="HEP86_RS21960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21960"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_168480592.1"
                     /transl_table=11
                     /translation="MTDTDPPLPPDDLAHRLTEVFDLVGPLYRRVQRKVEQTAPIEGLS
                     VGVRAVLDLLRENGPMTVPQMGRAQALSRQFVQRMVHDAAARHLVEITPNPAHQRSSLI
                     RLTDDGRAAITAVLLREHALLRQVDGDLTDAEVTACVRVLTRMLALFDHVDVG"
     misc_feature    7040..7053
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            7087..7917
                     /locus_tag="HEP86_RS21965"
                     /old_locus_tag="HEP86_21965"
     CDS             7087..7917
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (26-256). E-value:
                     2.1e-22. Score: 71.8. Matches aSDomain:
                     nrpspksdomains_HEP86_RS21965_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979827.1"
                     /locus_tag="HEP86_RS21965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21965"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_168480593.1"
                     /sec_met_domain="PF00561 (E-value: 4.7e-16, bitscore: 58.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.8e-20, bitscore:
                     73.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDALDVRTLETPDGLLAYRELGSGRPVVLLHGGFVDGGMWDDQL
                     PYFARDHRVIVPDARGHGASANATRAFRPADDVAALLRHLDTGPAVLVGLSMGAATAVD
                     TALEHPGLVRALVVSGAGTSEPEYHHPWARGVMTAQARAMAAGDIEGWIDAFLMLAAGP
                     HRTVDAVDPQVIGRVRGMAERTLAKHTGAEPDWRVRVADTWARAAKITVPVLAVHGGLD
                     SDDCIGMAERLVRSVAHGRAATIDGTGHYPNMERPDLFNRTVGAALPALFAHEN"
     misc_feature    7114..7116
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        7165..7854
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS21965_Abhydrolase_1.1"
                     /evalue="2.10E-22"
                     /label="HEP86_RS21965_Abhydrolase_1.1"
                     /locus_tag="HEP86_RS21965"
                     /protein_end="256"
                     /protein_start="26"
                     /score="71.8"
                     /tool="antismash"
                     /translation="PVVLLHGGFVDGGMWDDQLPYFARDHRVIVPDARGHGASANATRA
                     FRPADDVAALLRHLDTGPAVLVGLSMGAATAVDTALEHPGLVRALVVSGAGTSEPEYHH
                     PWARGVMTAQARAMAAGDIEGWIDAFLMLAAGPHRTVDAVDPQVIGRVRGMAERTLAKH
                     TGAEPDWRVRVADTWARAAKITVPVLAVHGGLDSDDCIGMAERLVRSVAHGRAATIDGT
                     GHYPNMER"
     CDS_motif       7345..7404
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEP86_RS21965_0001"
                     /evalue="1.10E-03"
                     /label="NRPS-te1"
                     /locus_tag="HEP86_RS21965"
                     /protein_end="106"
                     /protein_start="86"
                     /score="11.6"
                     /tool="antismash"
                     /translation="TGPAVLVGLSMGAATAVDTA"
     gene            8039..8986
                     /locus_tag="HEP86_RS21970"
                     /old_locus_tag="HEP86_21970"
     CDS             8039..8986
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089893.1"
                     /locus_tag="HEP86_RS21970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21970"
                     /product="hypothetical protein"
                     /protein_id="WP_168480594.1"
                     /sec_met_domain="RimK (E-value: 3.5e-06, bitscore: 25.6,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLCFLVEEQYRHDGMPLEVIHQLRAWGHRVDVLWPGRSLIRISE
                     AIQAGSHDAWVLKTVSGGPGLTLLEAAASVGLTTVNDVRAIRGVRDKALAAVIARGKGL
                     PVPVTYAAAHPEEFAEIAEAEFPLVVKPADGSSGRAVRLVATPDRLLEPGGPAGPDGSA
                     GGLLIAQPYVPNSGTDLKVYSVAGELYATERCSPLHPAHAVRERQVPLTPEVARITAEI
                     GAVFGLDLYGVDILLGPDGPVVVDINDFPSFRQVPDAVARVSAAVLELARNGAQGRDAF
                     ATRQTGAAAAPPSPFTASSVPRPTRPAASIGGGR"
     gene            8983..9845
                     /locus_tag="HEP86_RS21975"
                     /old_locus_tag="HEP86_21975"
                     /pseudo=""
     CDS             8983..9845
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089894.1"
                     /locus_tag="HEP86_RS21975"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21975"
                     /product="alpha-L-glutamate ligase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRVCLLTADPGHPLLAAVTGLLVPDHRVESLDPGAEGPGPDLSSL
                     ADVYLLKARTPRALALAALLEEHGAPVLNSAAATARCQDRVAMAAVARAAGCRSPLPAP
                     WPPWGSWPRPVPRTARW"
     gene            10001..12235
                     /locus_tag="HEP86_RS21980"
                     /old_locus_tag="HEP86_21980"
     CDS             10001..12235
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971162.1"
                     /locus_tag="HEP86_RS21980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21980"
                     /product="terpene synthase family protein"
                     /protein_id="WP_168480595.1"
                     /sec_met_domain="T1TS (E-value: 5.1e-81, bitscore: 272.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYTPHPARLNPHLETARTHSRKWARDMGLLEGSGIW
                     EEKDLDAHDYALLCSYTHPDCDADTLSLVTDWYVWVFFFDDHFLEKFKRTLDRKGGKEY
                     LDRLPAFMPMDLTAPLPEPANPVEAGLADLWLRTVPQMSMDWRRRFAESTEHLLNESLW
                     ELSNINIHRVPNPVEYIEMRRKVGGAPWSAGLVEYATGAEVPASVAASRPLRVLRDTFS
                     DAVHLRNDLFSYQRETEDEGELSNGVLVLENFLDCTTQEAADAVNDLITSRLQQFENTV
                     LAELPALFLEKGLDPASCVKVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGAAAGSSQPW
                     SPFSFGGLGTSAADLKTALATAGALRLRSGTHLPHQKVGPSQLPDFFMPFTTTLSPHLE
                     GARGRVIGWAHRMGLLRPQPGVPLSDVWDEPAMIRHDLALCAAGIHPDATPEQLDLDAA
                     WLAWGTYADDYYPAVFGRTRDIAAAKVCTERLSAFMPLDSATPVPEPVNALERGLADLW
                     PRTTAGMAPEARRAFRETIDTMTASWLWEIGNQIQNRIPDPVDYIEMRRATFGADLTMS
                     LSRLAHGRRVPPEIYRTGPLRSLENAAADYAGLMNDVFSYQKEIEYEGEVHNGILVVQT
                     FFGCDYPTALHIVDDLMTSRMREFQHVAAHELPVVYDDFQLSPEAREVLDGYVRELEHW
                     MAGILIWHRDCRRYRASELCHPTGSPGRLGAPTGLGTSAAGLFRSVARVG"
     misc_feature    complement(10002..10017)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            12458..14581
                     /locus_tag="HEP86_RS21985"
                     /old_locus_tag="HEP86_21985"
     CDS             12458..14581
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981083.1"
                     /locus_tag="HEP86_RS21985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21985"
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="WP_168480596.1"
                     /transl_table=11
                     /translation="MAAGSAPGGSAGASAARRAQQARRQERLLREQWQAARARAERWEA
                     ASEGEQRVAAQLLMLAERGWRLLVDRRWPGTRAANVDMLLIGPGGVFVIDVKNWRAAPE
                     ASAGRLRAGGFSRDEHRRKLLAVTKAAESAVASLGMSPVAVRPLLAFAGHRVDAELGRV
                     RLLGEREIGPALLSERTRLSAESVRALTEHLERVFPEYEAPPAATPDAATSDTASRIPD
                     AASDGLFDLDGLRDAALDEARRAPIEQWMTFLDPDQLALVRRNWAGPARISGPAGTGKT
                     VIALHRAAYLAQRTNGRILYVTFANNLPRVQATFLKTMAPAVADRVDFRSLHSWAQDYL
                     RDRGVPVHLHKEKAETAFSFAWKHVGRNSCLTEIDPLHPYWREEIDYVIKGRGITSFEE
                     YAALLRRRRRAGLRRPHRQAVWSLYEAYEAQRTERAVHDFNDVLSLALAEAAGRIGHSA
                     YTAVVVDEVQDLTLVGVRLLHALVGDTPNGLLLVGDGQQAVYPGGFRLSDAGIDIRGDR
                     AQVLRANYRNSKEIVDTALSVVAEDAFEDLDGLRTPGRRDIDLTYHDGEVQRAVLPTPA
                     AHDEALLTALRGLTPQELAGSAVLCPAKRAIEHYQRLLTRAGLRVCSLDRYDGHPVEAV
                     KLGSYRRAKGLEFKRVYLPQHDTPPPTGTPDGRTPAETAAERAELARSQLYVAMTRARD
                     VLWLGSVRPVREN"
     misc_feature    12542..12544
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14775..15503
                     /locus_tag="HEP86_RS21990"
                     /old_locus_tag="HEP86_21990"
     CDS             14775..15503
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089897.1"
                     /locus_tag="HEP86_RS21990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21990"
                     /product="chitin-binding protein"
                     /protein_id="WP_168480597.1"
                     /transl_table=11
                     /translation="MRRKIAFLGALALTGGLVAFAPSGAHAITGVITYHTRPDNRPHEI
                     LDPGDDHCYGVGDGYGEVDNDTPTDLVLYNGRDCTGSVVTVVRARGWLTARFGSLQLSS
                     DGPREEVPSADEDRPEDPDRSDNPDRSDDRDPAADDRDPAANDRDPADNDRDPATNDRP
                     NRSDGQDPADRPDRSDTPDSSGSSDPSDDLDHSDHPGDAQDPDRSEAPDQPASSASPVD
                     PVNAGTPGRHGRPGRPGAAG"
     gene            15606..16298
                     /locus_tag="HEP86_RS21995"
                     /old_locus_tag="HEP86_21995"
     CDS             15606..16298
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143693.1"
                     /locus_tag="HEP86_RS21995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_21995"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_248001244.1"
                     /transl_table=11
                     /translation="MGEREGGAPVAAGRTLRHFVGDAVWRELLGQVYERRHPAGDMMLR
                     QGEPGTHVLAVLSGVAKVLRRERNGDLTLLAFRGPGELLGEVAVLDDDVRSASVETISS
                     CTVGVVGKAEFLRFVVEHNLFPVLVRYAFTRMRESDEARGGGDTLTRLAATLVGLADIA
                     GQAGGRPGEPLELALTRHELAQYLGISRNTISSTLAELEPCEVRAGRKRIVLGDLTALR
                     RRAAASGS"
     gene            16477..17463
                     /locus_tag="HEP86_RS22000"
                     /old_locus_tag="HEP86_22000"
     CDS             16477..17463
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143694.1"
                     /locus_tag="HEP86_RS22000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_22000"
                     /product="hypothetical protein"
                     /protein_id="WP_168480598.1"
                     /transl_table=11
                     /translation="MSPSRPDLPEASAQPYSRSRPLPPYRGILAVDAKDFTGYPAIEHG
                     VISRAIPQLLQTSFERADIAEVWAERRFPDSTGDGYVFGFDPARMPFVIHPWLSTLQDV
                     LTQFHLHSTGAVRIRLRVSLHIGPLPDAGEECDGNGTPRNDTHRLLDSRPVKAMLAASS
                     ANITQVAAILSDRCYQDAVVSGYTGRHPDHFLQVPATVEGKQFDQAAWLYVPAPSGNLY
                     DRRILGDRVVEDHESGRSEHGAESRGAARRAAAPQVRNRADRGNVNSGTVYGGQSVQNV
                     EGGGDYIGGDYVGGDHFGGDYVGGNKAGTVHGNQGDTVHGDKHEGRR"
     gene            17460..19724
                     /locus_tag="HEP86_RS22005"
                     /old_locus_tag="HEP86_22005"
     CDS             17460..19724
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143695.1"
                     /locus_tag="HEP86_RS22005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_22005"
                     /product="hypothetical protein"
                     /protein_id="WP_248001245.1"
                     /transl_table=11
                     /translation="MSAEDARTDIPQQNDGASSEEPEPQAAGEEPPEGDIGFADPDEGD
                     FDEVAAEYALHGGEFAGLPFGRQPYPVIVAPRANINTGSVHGGQRVENHGGTTGTGGRR
                     VEAHEGPISAVEILDAQAGFAEPDWFPAALAELDSRLLFLTGEPGTGRRTAALNLLRRH
                     SGGSMNLRAVDGDMNLASWRPKHRESRGYLVDGLLPEYPLKPGMVRHLQSLLSRADARM
                     VVVLPDDPALVRRLSRELHVTPVRCAPPAARAVFDARFADAVPDPSERARRLALLEPGL
                     LDELLAPELVPAQVAELVAAVAAAEDGGPDLADIEKRLSFLAEGEVPDLLAQLRDDADG
                     LAFLLATCVFEGLDHRIVREEAERLLELADGRLSSVLPEGADGSDEDWRRDRERKPRPN
                     PQFVFRRSLDELLRTVRAQCSPREIRSNSGYTYAVEAVRFTRHRQAEAVLRHVWREYGH
                     LSRLLTEWMADLKNEQELTEPVGRVMGLAAGWGGGRRALQHIGTLATSSRRSSRTIAAY
                     ALGMAAGDPILAREVKYRLSLWSAQQSWQVRSTVAYTCGADFGASRPEVAMRLLRNVPR
                     GQGDEHERTVDRAVRDALNDLFASGSQATVFRHLAEWADGEGPLTDVALRTLPQLLQNT
                     PWCQEQLVNDGEYAAQIIGLVHRTLNDEELFVATCNAVLWWCRMAAWGDLPRTAVETLL
                     SALAADFRHGVLRLFVVIDRADVPDLAGLGIARDALHTWRNGEQPWQPVNGSTHPNGRT
                     S"
     gene            19721..20686
                     /locus_tag="HEP86_RS22010"
                     /old_locus_tag="HEP86_22010"
     CDS             19721..20686
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046982.1"
                     /locus_tag="HEP86_RS22010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_22010"
                     /product="hypothetical protein"
                     /protein_id="WP_211117394.1"
                     /transl_table=11
                     /translation="MTTDSNQPVYAPAAHAPWREILRHRWSGRLDRALVLREHSGAYRV
                     LGSRKRAPLRAADEVTGQASSAPRLLGGYDSAFHVQLHELSGTRSVALPTAYGTESVDL
                     RVLWWVHDPVDVVRSRTTDGWEAVRKELDRRLRHLEDAHAADGQTLGAPEIMQELAAPQ
                     QLDGFGLTYRVTDIRGQESEGELRLGQPGGAGLPYSWTAHRREEFRFCEEAVRSGPVSL
                     AALWLVRHPDQVSQVLDWTVNHRGLLKEETDWQDEIAGLLGELTEQERQELSGLLRDRL
                     AGLGRRVPAPSAPQEAPSDKGPGSREVNGHWRGTAKEWSV"
     gene            20869..21342
                     /locus_tag="HEP86_RS22015"
                     /old_locus_tag="HEP86_22015"
     CDS             20869..21342
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040152.3"
                     /locus_tag="HEP86_RS22015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_22015"
                     /product="Pycsar system effector family protein"
                     /protein_id="WP_168480599.1"
                     /transl_table=11
                     /translation="MERFLAANGVEIARADTKAAVLLGFMGAVLGAFITVTRGATTHQA
                     AASWKADVLWWGAVTTALLAIVCFVSAIAPRRRRGRKPGLAGPGYFEHIGRGEDGEGLS
                     HAFARIAHDPTGPLLDSVRRTSAIIRSKYRWIETGTALLLVALPQFAAALQPG"
     misc_feature    21328..21330
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21410..21425)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.86"
                     /tool="antismash"
ORIGIN
        1 tgctgccctg gagatccggc ggctgccagg gctcggcgtg gcggggtagt tgggcgggtg
       61 cccgccggtg ccgccgggtc ggccggtgac cgggcggggg tcagggttcg atgactcccg
      121 cgtggtcgct ggacggcgac aggatcgccg acccggtgga gccgccgacg aactcggcgt
      181 catagccgcc gttggcgagg atgagcgtca ggatgagcgt ctcgttgaac cgggcgacgc
      241 cttgggcgtc ggtggtggcg atgcccacga ggttgctgcc gatcttgaag aggatggtct
      301 ggccgggcac gggcagcccg gtgacctggt cggtcagcgt ggcggtcagg aacgggaagt
      361 acacgtgcgg cgggaacagc ttcgacagcg ccggggtcgc gaccagcgag gtggcgtgga
      421 cgggcagcag gtaggtgaag ccgttcacca ggctggcact gccaccaggg gtggtgacgg
      481 tgacggtcac gggaccggcc gccgccccgg gcggagtggt ggcggtgatc tgcgtgccgg
      541 cggcgttgac gctcaccccg gtggcgggga tgccgccgaa gtcgacactc gccccggtca
      601 ggttggtgcc ggtgatcgtc acgaccgtgc cgcccgcgat gggcccttgg gtggggacga
      661 tgctggtcag cgtcgggtcg aattggatga cgctgacgtt gttcccgttg atgttgctga
      721 cgtagacctt gttgttgggg gcgaccgtca cggcgatcgg tccggcgccg acggggatcg
      781 gggcgccgac gacggtgttg gtggcggtgt cgaacaccgt cacgctgttc gccgcccggt
      841 tggacgtgta ggccatcccg tcggcgccga ccgcgatgcc ccacggctgg ttgccgacgg
      901 cgatcggggc gccgacgacg gtgttgctga tggtgttgat caccgtcacg gtgttcgacc
      961 cgatgttggc gacgtaggcg ttgccgttgg gtgcgatcgc cacgaagttc ggctgggcgc
     1021 cgacggggat cggggcgccg atgacggtgt tggtggcggt gttgatcacc gtcacggtgt
     1081 tcgatccccg gttggtgacg taggcgttgc cgttggaggc gaccgcgacc ccgaccggct
     1141 gggcgccgac ggcgatcggg gcgccgatca cggtgttcgt ggtggtgtcg atcaccgtca
     1201 cggtgttcgc ggcgaagttg gtgacgtaga cgcgtccgcc ggggacggcc gccaccacgg
     1261 ccggctggtt gccgacggcg atcggggcgc cgacgacggt gttggtggcg gtgttgatca
     1321 ccgacacggt gttcgacccg ctgttgggga cgtaggcgtt gccgttgggg gcgaccgtca
     1381 gccagaccgg cgtaccgccg acgccgatcg ggccaccgat gacggtgtcc gtggtggtgt
     1441 tgatcgccga cacgttggcc gacccggagt tggcgacgta gaggtcgctg ctgggggcga
     1501 tcgccagccc gaccgggttg ttgccgacgg ggatcgacgt gacggccagg aagacttgcg
     1561 ccgaggctgc caccgggctc acctgcgccg cctggctggg gagcgcggct gtctgcagca
     1621 gcagttccag catcggcgac tgaacttgcg tactcatgtg gaccccttct gtgggggccg
     1681 tccatatccc gctccggggc accacaacta cagaccgcgc gtcacaaaaa cgacgcgggc
     1741 tgcccatccc cgaggaggga tgggcagccc agtagttcgg ttatcgccct ttttccccat
     1801 gctgcgggga agcgaaacat tcgcacatgc ttgcccgtga ccggcgcttt cacccgtcgg
     1861 catccaggtc gtccggtgcg ggcgagccgc ccgcaaggag gggggagttc cccggctccg
     1921 gctgatcagc ggaacgggag cgggtggccc cgctcctcct ccgggcgggg gccgaagatg
     1981 cggcgttcgt cgccggtgat cgcgacatcg tggatgccgg cctcccggcg gcgcatcagg
     2041 ccgttctcgt cgaactccca gagctcgttg ccgtagctgc gccaccactg gccggccgcg
     2101 tcatgggact cgtactggaa gcgcaccgcg atgcggttgc cgctgtacga ccacagctcc
     2161 ttgcgcagcg cgtagtccag ttcgcgggtc cacttccggc gcaggaagtc gacgatctcg
     2221 gcgcggccgg tgacgaaggt gtcgcggttc cgccagaccg agtcctcggt gtaggcgagg
     2281 gcgacccgct ccgggtcgcg ggtgttccag gcgtcctcgg ccgcctgcac cttctgttgt
     2341 gcgctctgct cgtcgaacgg cgggaagggc ggtcgtggcg ccatggcggg ctccctttca
     2401 ccaagatcgg agaacgggcg ttctcgcttg gtcggctagt gtagagaacg accgttctcc
     2461 tggaaagccc cggaagtgcc atggatctcg atgaagcccg tacgcggata ctcgacgccg
     2521 cggagaagct gttctacgac cgcggcatcc aggccgtcgg gatggatgaa ctccgcaccg
     2581 ccgccggggt gtcgctcaag cggctctatc agtgcttccc cgccaagcac gacctcgtcg
     2641 aggcgtatct gcgccgccgt gacacccgct ggcgcaccgc actcgccgag tacgtcgacg
     2701 cgcacgccga cggccccgcg gaccggccgc tcgcggtctt cgactggctg ggcgactggt
     2761 tcgcggagga cggcttccgt ggctgcgcct tcattaatgc gtacggagag ctgggggcga
     2821 cctccggccg ggtcgggtgc gtcgcgcggg agcacaagga ggcgctgcgg gggtatgtgg
     2881 ccggtctggt gcgcgcgctg ccggtggccg aaccggaggt gctggccggg cagttggcgc
     2941 tgctgatcga cggggcgatc gcgggtgccg ccctcctggg tgagccgtcc gccgcccggc
     3001 aggcccgtac cgccgccgcc gcgctcctgg aggcggcggg gagtgtggcg gggccagggg
     3061 cggcgcgcaa cggaacctga tggcacatga gttcgagagc cgactaagat caactacgtg
     3121 cacgcggtgc ccgccacgcc ccatttcgtg gcgggatttt tcgcgtcttc cgccggtatt
     3181 tcgaggagag gactcccccc ccacacatga cccgttcgaa gctgctccgc gcgctgaccg
     3241 tcgccggaac gatcgcgctg agcgccgtcg ccaccacccc ggccgcgcac gccgccgcct
     3301 cctcctgcac ccacgactgg tcggggccgc agatctgcat cgagaccgat ggccaggacg
     3361 gcacgcccca gcccggcacc gtcaccgcga cctggaccaa cccgtccaag agtcggcagt
     3421 ccgcgaccgt ctacctcacc actacggacg gcgggagcaa ctactccttc aaggcgaagc
     3481 ggtccggtga ccagatcgtc ggccacaccg ccccggggat ccagccgagc ggcagcacgc
     3541 tctgtgtccg tttcaagggc agctcgcaca aggcctgcct ggagatgatc aaccgcaacg
     3601 gctcgttcta gcgcacgcgg acacgacgcg gccgcagctc acccgagctg cggccgcgtc
     3661 ggccgttcgg cggggtgccg ggtcagccca gcgcccgctc caggctgccg agcgccgagg
     3721 tcagttcctc ggcggtgatg gtcagcggcg gggccagccg gatcgtcgag ccatgggtgt
     3781 ccttgaccag gacgccttcc ttcagcagac gttcgctgat ctcccggccg gtgcccaggg
     3841 cggggtcgat gtcgacaccg gcccacaggc cgcgggcgcg gaaaccggtc acacccttcc
     3901 cggtcagtgc ggccaggccg tcgcgcagta cggcgccgag ttcggtggcg cggcgctgga
     3961 actccccggt ggcgagcagc tcgatgacgg ccgaaccgac cgccgccgcc agcgggttgc
     4021 cgccgaaggt cgagccgtgc tggccggggc cgatcacgcc gagcacgtcg cggcgggcga
     4081 cgaccgcgga gaccgggacg atgccgccgc cgagcgcctt gccgagcagc agcatgtccg
     4141 gcaccacgga ctcgtgctcg accgcgaggg tggtgccggt gcggcccagc ccggactgga
     4201 tctcgtcggc gatgaacaga cagccgttgc gccgggtcag ttcgcgtacg ccggtgaggt
     4261 agccgtcgtc ggggatcagg acgcccgcct cgccctggat gggctcgatc agcacggcgg
     4321 ccgtcgtctc gtccagggcc gcctccagcg cggcgagatc gttgtacggg acggtgcgga
     4381 agccgggggc gaaggggccg aagccgaccc gggcggtgtc gtcgtcggag aagccgacga
     4441 tggtggtcgt ccggccgtgg aagttgccgc ccgccaccac gatcgtcgcc cggtccgccg
     4501 ggacgccctt gacgtcgtac gcccacttgc gggcgacctt gatgccgctc tccaccgcct
     4561 cggcgccggt gttcatcggc aggaccatgt ccaggccggt cagctcggcg aggccctcgg
     4621 cgaaaccggc gagccggtcg ttgtggaacg cccgtgaagt gagggtgagc tggtcgagct
     4681 ggcggtgcgc ggcctcgacc agggccgggt ggcgatggcc gaagttgagg gccgagtaac
     4741 cggccagcat gtcgaggtag cggcgcccct cgacgtcctc gacccagacc ccttcggcgc
     4801 gcgcgaccac cacgggcagc gggtggtagt tgtgcgccag aaccgggctc tcggcctgga
     4861 tgagctccgc ggacgaacgg ggagcgccaa cctgggcggt acgggtggga gcggtcatga
     4921 gcggatctcc tgggtgcagc acttgatgcc gccgccggcc ttgtggaact ccgacaggtc
     4981 gacggggacg gggacatagc cgtgcgcgag gagctgagcg atcaggccgg atgcctgcgg
     5041 ggcgacgaag acatggcggc cgtcggagac ggagttgagg ccgaaggcca tcgcgtcctc
     5101 ccgggtggcg agcaccgcgt cggggaacag ccgccgcagc acctcacggc tgccggacga
     5161 gaacgcctcg gggtaatagg cgatatgcgc ctcgcccgtc tccggcgatt cgccgaggac
     5221 gaagagcgcg gtgtccaggt ggtagaagta cgggtccacc agctggaggc cgatcgtcgg
     5281 caccccgaag aactcctgca cctcgcggtg cgccgccggg gtggtgcgaa agccggtgcc
     5341 cgccaggatg aagcggccgg ccgggacgag atcgccctcg ccctcgcacg ccgactccgg
     5401 ccggtagacg tcgtagccgg ccgccttgaa ccaggtctcg tactccgtgg actccggccg
     5461 ccgctgcggc gcgtggaagt gcgagccgaa gacccggccg cccacgacca gcgcggagtt
     5521 ggccgcgaac accatgtccg gcagaccggg caccgggggc accgactcca cggtgtgccc
     5581 atgggcgcgg taggtgccca tcagcgcctc ccactggcgc cccgcgagcg cggtgtccac
     5641 gggcacgtcc gcccgcatcc agggattgat ggcgtaatgc acggcgaagt gtctgggctc
     5701 gcagaccaga tagcgccggg ggcgggattc acgactcatc ggcacgggac gatcccttcg
     5761 cttcctcggg caatgcgggg tgaccggggg tcacagagcg tcaccccgat ggcttccaag
     5821 gtaaggagcg agggattcgg gccacaagca acaaatgctg ctgatcggcg cagcaatgct
     5881 gcgtgtctgt gacctcttac gcagctttgc tgcgcgcttc cgtcccggat tccgcttccc
     5941 cggagggagc gcgcagcttc cggcggctaa gacgggccac gcgcatccgg cgcctcagcc
     6001 gacggtcccg ccggagggct gccgggcgcc cgcctccggg ctgtccggca gcagatggga
     6061 cagcaccatg taactgatcg tcttgcggat gaacggctcg gcccggatgc gttcgagcac
     6121 ctcctcgaag tgctccacat cggtcgcccg tacgtgcagc agcgcatccg cgccaccggt
     6181 gaccgtcatc gccgctgcga tctccgggtg gttgcgcacc acctccgcga gccgccgggg
     6241 cggcgccgcg ctgtcgcagt acacctcgac atacgcctcg gtcagccacc ccagcgcggc
     6301 cgggcgaacg gtggcggtga accccgtgat cacgttgttc tcccgcatcc ggtccacccg
     6361 ccgcttcacc gcggtggacg acagcccgat cgccgccccg atctccgcga agctcgcccg
     6421 gccgttgtcg atcagcgccg caacgatctt gcggtcgagg tcgtcgaagg gcacggcctt
     6481 gtgggtcact gggcctcccg atcccgtccc ggtcccgcgt cgtcgcgggt gcctcacggt
     6541 agcgggagag tggtcagccc acgtcgacgt ggtcgaagag cgccagcatc ctggtgagca
     6601 cccgcacgca cgccgtgacc tcggcgtcgg tcagatcgcc gtcgacctgg cgtagcagcg
     6661 catgctcgcg caggagcacc gcggtgatgg cggccctgcc gtcgtcggtc agccggatca
     6721 gcgaggagcg ctgatgggcg gggttggggg tgatctcgac caggtgccgg gccgcggcgt
     6781 cgtgcaccat gcgctgcacg aactgccggc tcagcgcctg tgcgcggccc atctgcggga
     6841 cggtcatcgg gccgttctcg cggagcaggt ccaggacggc gcggacgccg acggacaggc
     6901 cctcgatcgg agcggtctgt tcgaccttgc gctggacccg ccggtacagc gggcccacga
     6961 ggtcgaacac ctccgtgagc cggtgggcga ggtcatcggg cggcaggggt gggtcggtgt
     7021 cggtcacggg gaccatcatg gcaccttagt tgccaagttg ccgcggaaga tggcaccttg
     7081 gttgtcatga ctgatgccct tgatgtgcgc acgttagaga cgccggacgg acttctcgcc
     7141 tatcgcgaac tcggcagtgg ccggcccgtg gtgctgctgc acggcggttt cgtggacggc
     7201 gggatgtggg acgaccaact gccgtacttc gcacgggacc accgggtgat cgtgccggac
     7261 gcccgggggc acggcgcgtc cgccaacgcg acccgggcct tccgccccgc cgacgatgtc
     7321 gccgcgctgc tgcgccacct cgacaccggc cccgccgtcc tggtgggact gtcgatgggc
     7381 gcggccacgg cggtggacac cgcgctggaa catcccggtc tggtgcgcgc gctggtggtc
     7441 agcggcgccg ggaccagtga gccggagtac caccacccct gggcccgggg cgtgatgacc
     7501 gcccaggccc gcgcgatggc cgccggcgac atcgagggtt ggatcgacgc cttcctgatg
     7561 ctcgcggccg gcccgcaccg cacggtcgac gcggtcgatc cgcaggtcat aggacgcgta
     7621 cggggcatgg cggagcggac gttggccaag cacaccggcg ccgaaccgga ctggcgggtg
     7681 cgggtggccg atacctgggc gcgggccgcg aagatcacgg tcccggtgct ggccgtccac
     7741 ggcggcctcg actcggacga ctgcatcggt atggccgaac gcctcgtgcg gtccgtcgcg
     7801 cacggccgtg ccgccaccat cgacggcacc gggcactacc ccaacatgga gcggccggac
     7861 cttttcaacc ggacggtggg ggcggcactg cccgccctct tcgcgcacga gaactgacgc
     7921 acccgggccg gagcccggtg cgtgggtgca ccgtccccgg cgggctccgc atgggatcct
     7981 ggtgtgtcga ggatctgccg gacggtcggt ggacgtgcgg cgatgacgag ggtgcctgat
     8041 gagactctgc ttcctggtgg aggagcagta ccgccatgac ggcatgccgc tggaggtgat
     8101 ccaccaactc cgcgcctggg gccaccgggt ggacgtgctg tggcccggcc gctcgctgat
     8161 ccggatatcc gaggcgatcc aggcgggcag ccacgacgcc tgggtcctca agaccgtctc
     8221 cggcggtccg ggcctgacgc tcctcgaagc ggccgcttcg gtcgggctga cgacggtgaa
     8281 cgacgtccgg gccatccgtg gcgtacggga caaggcgctg gccgcggtga tcgcccgcgg
     8341 caaggggctg ccggtcccgg tgacgtatgc ggcggcccat cccgaggagt tcgcggagat
     8401 agccgaggcg gagttcccgc tcgtggtgaa gcccgccgac ggcagttccg ggcgcgccgt
     8461 gcggctggtg gcgacgccgg accggctgct ggagccgggc ggcccggcgg gccctgatgg
     8521 gtcggccggc gggctgctga tcgcccagcc ctatgtcccc aactccggta cggatctgaa
     8581 ggtctacagc gtcgccgggg agctctacgc gaccgagcgg tgctccccgc tgcacccggc
     8641 acacgccgta cgggaacggc aggtgccgct gacgcccgaa gtcgcccgga tcaccgccga
     8701 gataggcgcc gtcttcggcc tcgacctcta cggggtcgac atcctgctcg ggccggacgg
     8761 cccggtggtc gtcgacatca atgacttccc cagcttccgt caggtgccgg acgcggtcgc
     8821 ccgggtgtcc gccgcggtcc tggagctggc ccggaacggg gcgcaggggc gggacgcgtt
     8881 cgccaccagg cagactggcg cggcggccgc cccgccgtcc ccgttcaccg cgtcgtccgt
     8941 tccccgtccc acccggcccg cggcgtcgat cggtggcggc cggtgagggt ttgtctgctc
     9001 accgcggacc cggggcatcc gctgctggcc gcggtcaccg gcctgctggt gccggatcac
     9061 cgggtcgaaa gcctggaccc gggcgccgag gggccgggcc cggacctctc ctcgctcgcc
     9121 gatgtctatc tcctcaaggc gcggacgccc cgggcgctgg cgctcgccgc gctcctggag
     9181 gagcacggcg ccccggtgct caactcggcg gcggcgaccg cccggtgcca ggaccgggtg
     9241 gcgatggccg cggtggcccg cgcggcgggc tgccgttcgc cgctacccgc tccgtggcca
     9301 ccctggggga gctggccgcg gccggtgccc cggacggccc gctggtgatc aagagccggt
     9361 tcagccgccg ccgggacctg gtgacccgcg ccgacagcgc cgtacggctg cgggaactgg
     9421 ccgccgactg ggccgaggag ccggtggtgg tccaggactt cacccccaac agcggctggg
     9481 accacaagct gtgggtggtc gacgggcagc tcttcgccgc gctgcgccgc tcggagctgg
     9541 ccccggacgg ccgcggtccg aacctgccgc ttccggtcgg cgaactgccc gcgagctgga
     9601 ccgccgccgc gctccgggtc ggcgaggtct tcggcttgga ggtctacggg gtggatctgc
     9661 tcgacgccgg gggcggtgcg ccgctcatcg tggacatcaa cgcctttccc gggatccgtg
     9721 gccaggccgg tgccccggag gcgctggcgg cgctcgccct gcggaccgca gagcgcgggc
     9781 gggccggcgg cgcggacgaa gaaaacgcgg acgaaagaaa agtgccacaa gtcagcgaga
     9841 aatgaacccg gttggtgtcg ctccgaaccg aaggggagcg gaggcggaag ctcctcctcc
     9901 gtaaggtcta aggggccggg ccccggggta gcgcagcccc gtcagggggg cgtgatccac
     9961 cgcgccttcc ttccgtacgt atggggagag gccagcaacg gtgacacagc ccttcgaatt
    10021 gccgcacttc tatacgcccc atccggcgcg cttgaacccg catctggaga cggcgcgtac
    10081 gcattccagg aagtgggccc gcgacatggg actgctggag ggctcaggca tctgggagga
    10141 gaaggatctc gacgcccacg attacgccct gctgtgttcc tacacccacc cggactgcga
    10201 cgccgacacg ctgtcgctgg tgaccgactg gtatgtctgg gtcttcttct tcgacgacca
    10261 cttcctggag aaattcaagc ggacgctgga ccggaagggc ggcaaggagt atttggaccg
    10321 gctgcccgcg tttatgccga tggacctgac cgcgcccctt ccggagccgg ccaacccggt
    10381 cgaggccggg ctcgccgacc tgtggctgcg cacggtgccg cagatgtcca tggactggcg
    10441 gcggaggttc gccgaaagca ccgagcatct gctcaatgag tcgctgtggg aactgtccaa
    10501 tatcaatatc caccgggtgc ccaaccccgt tgaatacatc gagatgcgcc gcaaggtcgg
    10561 tggcgcgccc tggtcggcgg gcctggtgga gtacgcgacc ggcgccgagg tgcccgcgtc
    10621 cgtcgccgcg tcccggccgc tgagggtact gcgggacacc ttttccgacg ccgtccatct
    10681 gcgcaacgac ctcttctcct accaacgcga gacggaggac gagggcgagc tgagcaatgg
    10741 cgtcctggtg ctggagaatt tcctggactg caccacccag gaggcggcgg acgccgtcaa
    10801 cgatctgatc acctcccggc tccagcagtt cgagaacacc gtcctcgccg aactccccgc
    10861 gctcttcctg gagaaggggc tcgatccggc ctcctgcgtg aaggtgctgg cgtacgccaa
    10921 ggggctccag gactggcagt ccggcggtca cgaatggcat atgcgctcca gccgctacat
    10981 gaacggcggc ggggcggcgg ccggcagctc gcagccctgg tcgcccttct ccttcggcgg
    11041 cctcggcacc tcggcggcgg acctgaaaac cgccctggcc acggccggtg cgctccgcct
    11101 ccgcagcggc acccacctgc cgcaccagaa ggtcgggccg tcccaactcc ccgacttctt
    11161 catgccgttc accaccaccc tcagcccgca cctggaaggc gcccgcggtc gcgtcatcgg
    11221 gtgggcgcac cggatgggcc tcctccggcc gcagcccggt gtgccgctct ccgacgtctg
    11281 ggacgagccc gcgatgatcc ggcacgatct ggcgctgtgc gcggccggca tccacccgga
    11341 cgccaccccg gagcaactgg acctggacgc cgcctggctg gcctggggca cctacgccga
    11401 cgactactac ccggcggtct tcggccgcac ccgcgacatc gcagcggcca aggtgtgcac
    11461 cgagcggctg tcggccttca tgccgctcga ctccgcgacg cccgtaccgg agccggtcaa
    11521 cgccctcgaa cgcgggctgg cggacctgtg gccccgtacg acggccggta tggctcccga
    11581 ggcgcgccgg gcgttccgcg aaaccatcga caccatgacc gccagctggc tctgggagat
    11641 cggcaaccag atccagaacc gcatccccga cccggtcgac tacatcgaga tgcgccgggc
    11701 gaccttcggc gccgacctca ccatgagcct gagccggctc gcccacggcc ggcgggtccc
    11761 gccggagatc taccgcaccg gcccgctgcg ctcactggag aacgccgccg ccgactacgc
    11821 gggcctgatg aacgacgtct tctcctacca gaaggagatc gagtacgagg gcgaggtcca
    11881 caacggcatc ctggtcgtcc agaccttctt cggctgcgac tacccgaccg cgctgcatat
    11941 cgtcgacgac cttatgacct cgcgcatgcg ggagttccag catgtcgcgg cccatgaact
    12001 ccccgtcgtc tacgacgatt tccagctctc gccggaggcg cgcgaggtgc tggacggcta
    12061 tgtccgcgag ctggagcact ggatggccgg catcctcatc tggcaccgcg actgccggcg
    12121 ctaccgggcc tccgagctgt gccacccgac gggttcgccg ggccgtctgg gcgcgccgac
    12181 cggcctgggc acctccgcgg ccggtctctt ccggtcggtc gcgcgggtcg ggtagacggg
    12241 cggcggcccg gcccggtccg gctcgctgcc gccggggccg gggccgggcc gtcgtgggct
    12301 ccgcgcccga tgcgcccgtg ccccgcccgt gcgcacttcc gcgtcatgtg ccatcgacct
    12361 atggttcatg actcatgtgg ttcacgactc atgtgggtca tgacccatgt ggtgcgtggc
    12421 ccatgcgttc ggggggcgag cggtgagggg gcgaacgatg gcggcaggga gtgcaccggg
    12481 cgggtcggcg ggtgcgtcgg cggcccggcg ggcgcagcag gcccgtcggc aggagcgcct
    12541 gttacgggaa cagtggcagg ccgcccgagc gcgggccgag cgctgggagg cggcgagcga
    12601 gggggagcag cgggtcgccg cccagctgct gatgctggcc gagcggggct ggcggctgct
    12661 ggtggaccgg cgctggccgg gcacccgcgc ggccaatgtg gacatgctgc tgatcggccc
    12721 cggcggagtc ttcgtcatcg acgtcaagaa ctggcgggcc gcgccggagg cctcggccgg
    12781 ccggctgcgg gccggtggct tctcccgtga cgagcaccgc cgcaagctgc tcgcggtcac
    12841 caaggccgcc gagagcgcgg tggcgtccct ggggatgtcc ccggtggcgg tgcgcccgct
    12901 gctggcgttc gcggggcacc gggtcgacgc ggagctgggc cgggtgcggc tgctgggcga
    12961 gcgggagatc ggaccggcgc tgctgtcgga gcgcacccgg ctgtccgccg agtccgtccg
    13021 cgccctcacc gagcatctgg aacgggtctt ccccgagtac gaggcgccgc ccgccgccac
    13081 cccggacgcc gccacatcgg acaccgcctc ccgaataccg gacgccgcgt ccgacggcct
    13141 cttcgacctc gacggactgc gggacgccgc tctcgacgag gcgcggcggg cccccatcga
    13201 gcagtggatg actttcctcg accccgatca gctcgccctc gtacggcgca actgggcggg
    13261 cccggccagg atcagtggcc cggccggcac cggcaagacg gtcatcgccc tgcaccgcgc
    13321 cgcctacctg gcccagcgca ccaacggccg catcctgtac gtcacgttcg ccaacaacct
    13381 gccccgcgtc caggccacct tcctgaagac gatggccccc gcggtggccg accgggtcga
    13441 cttccgcagc ctgcactcct gggcacagga ctatctgcgc gaccggggcg taccggtcca
    13501 tctgcacaag gagaaggcgg agacggcctt cagcttcgcc tggaaacacg tcggccggaa
    13561 cagctgcctg accgagatcg atccgctgca cccgtattgg cgggaggaga tcgactacgt
    13621 catcaagggc cgcggcatca cctccttcga ggagtacgcc gcgctgctgc gccgtcgccg
    13681 ccgcgccggg ctgcgccgcc cgcaccggca ggccgtctgg tccctgtacg aggcgtacga
    13741 ggcgcagcgc accgagcgcg ccgtgcacga cttcaacgat gtgctctccc tcgcgctcgc
    13801 cgaggcggcc ggccggatcg ggcacagcgc ctacacggcc gtcgtcgtgg acgaggtcca
    13861 ggacctgacc ctcgtcgggg tgcgcctgct ccacgccctg gtgggcgaca cccccaacgg
    13921 tctcctcctg gtgggcgacg gccaacaggc cgtctacccg ggcgggttcc gtctctcgga
    13981 cgcgggcatc gacatccgcg gcgaccgcgc ccaggtactg cgcgccaact accgcaacag
    14041 caaggagatc gtggacaccg cgctctccgt cgtcgccgag gacgccttcg aggacctcga
    14101 cgggctgcgc accccgggcc ggcgggacat cgacctgacc taccacgacg gcgaggtgca
    14161 gcgcgcggtc ctgcccaccc ctgccgcgca cgacgaggcg ctgctgaccg cgctgcgcgg
    14221 cctgaccccg caggagctgg ccggatccgc cgtcctgtgc cccgcgaagc gcgccatcga
    14281 gcactaccag cgcctgctca cccgggccgg cctgcgggtc tgctcactgg accgctacga
    14341 cggacacccg gtggaggcgg tgaaactcgg cagctaccgc cgtgccaagg gtctggaatt
    14401 caagcgcgtc tatctgccgc agcacgacac cccgccgccc acgggcaccc cggacggccg
    14461 cacccccgcc gaaaccgccg ctgagcgcgc cgaactggct cgcagtcagc tctacgtcgc
    14521 catgacccgc gcccgcgacg tcctctggct gggcagcgtc cggccggtac gggagaactg
    14581 agcgacggga ggcggcgtcc gccccgacgc accctccccg agccggccga tgccgcccgt
    14641 aatgtccttc tgcacggtga atctcccctt tggcgggaat atcccgggag ggcgtcggga
    14701 accccacatg gcgacatccc gtaggggcct ggcccaggac cggcccgccg ccatggctga
    14761 caggagttcc gactgtgcga cgcaagatcg ctttccttgg tgcgctggct ctcaccgggg
    14821 ggctcgtcgc gttcgctccc tccggcgcgc atgccatcac cggcgtcatc acgtaccaca
    14881 cccggcccga caaccggccg cacgagatcc tcgaccccgg cgacgaccac tgctacggag
    14941 tgggggacgg ctacggcgag gtggacaacg acacccccac cgacctcgtc ctgtacaacg
    15001 gccgcgactg caccggctcc gtggtgaccg tcgtgcgcgc ccgcggttgg ctcaccgcga
    15061 ggttcggcag cctccagctg agctcggacg gtccccgcga agaggtcccc tccgctgatg
    15121 aggaccgccc cgaggacccg gaccgctcgg acaacccgga ccgctccgac gaccgcgacc
    15181 ccgccgccga tgaccgggat ccggccgcca acgaccgcga ccccgccgac aacgaccggg
    15241 acccggccac caacgaccgc ccgaaccgct ccgacggcca ggaccccgcg gaccgcccgg
    15301 accgctccga caccccggac tcctccggca gctccgaccc ctcggacgac ttggaccact
    15361 ccgaccaccc gggtgacgcg caggaccccg accgctcgga ggcccccgac cagcccgcaa
    15421 gttcggcaag cccggtggac ccggtcaacg cggggacccc gggacgccat ggacgaccgg
    15481 gacgcccggg ggcggcgggc tgaggcgggg ctgagggggc cgaggtgcga gggagccggg
    15541 cggggaccgg ctcccgtcac cgccttccgc ggacgcggcg ggaggagttc ttctaggctc
    15601 gccacatggg tgagcgcgaa gggggagcgc cggttgcggc aggccggacg ctgcggcact
    15661 tcgtgggcga cgcggtctgg cgggagctgc tgggccaggt ctacgagcgc cggcatccgg
    15721 ccggggacat gatgctccgt cagggggagc cagggacaca tgtgctggcc gtgttgagcg
    15781 gggtcgccaa ggtgctccgg cgcgagcgga acggggatct caccctgctg gccttccgcg
    15841 ggccggggga gctgctcggc gaggtcgctg tgctggacga cgacgtacgg tcggcgagcg
    15901 tggagacgat ctcgtcgtgc accgtggggg tcgtcggcaa ggcggagttc ctgcggttcg
    15961 tcgtggagca caacctgttt ccggtgctgg ttcggtacgc gttcaccagg atgcgggagt
    16021 cggacgaagc ccgcggcggt ggtgacaccc tgacccggtt ggcggccacg ctggtggggc
    16081 tggccgatat cgccgggcag gcgggcggac gccccggcga gccgctggag ctggcactca
    16141 cgcgccatga actggcccag tacctgggca tttcccgtaa cacgatctca tcgacgctcg
    16201 ccgagctgga gccctgcgag gtgcgggccg gacggaaacg catcgtcctc ggtgatctga
    16261 ccgccctgcg ccggagggct gccgccagcg gcagctgacg ccccgttcgg tgtggtgcgc
    16321 gtcacgtcgt cactgcacta cgtgtgcaca ccggaggacc gtcgctcgcg agactcgggt
    16381 ggtggagctg aacgatgggt tcagccccgg ttcatgacgg cccgacgccc ggccatgaac
    16441 ccggtgaaga ccgcacggga aagccaagga gttccgatgt caccgtcccg cccggacctg
    16501 cccgaagcca gtgcccagcc ctattcccgc agccggccgc tgccgccgta ccgggggatc
    16561 ctggcggtcg acgccaagga cttcaccgga tatccggcca tcgagcacgg cgtgatcagc
    16621 cgggccatcc cgcagctcct ccagacctcg ttcgagcggg ccgacatcgc cgaggtctgg
    16681 gccgagcgga ggttccccga ctccaccggc gatggatatg tcttcggctt cgacccggcg
    16741 aggatgccgt tcgtcatcca cccctggctg agcaccctcc aggacgtcct gacccagttt
    16801 catctgcact ccacaggcgc ggtgcgcatc cggctcaggg tgagcctcca catcggcccg
    16861 ctgcccgatg cgggggagga gtgcgacggc aacggcacac cgcgcaacga cacccaccgc
    16921 ctgctcgact cccgcccggt caaggccatg ctggcggcct ccagcgccaa catcacccag
    16981 gtcgccgcca tcctctccga ccgctgctac caggacgcgg tggtgagcgg ctacaccggg
    17041 cggcaccccg accacttcct ccaggtgcca gccaccgtcg agggcaagca gttcgaccag
    17101 gcggcctggc tgtatgtccc ggccccgtcg ggcaatctgt acgaccgtcg catcctcggg
    17161 gaccgggtgg tcgaggacca tgagtccggg cgcagcgagc acggtgcgga gtcccggggc
    17221 gccgcgcgcc gggccgccgc cccgcaggtg cggaaccggg ccgaccgcgg gaacgtcaac
    17281 agcgggaccg tatacggcgg tcagagcgtc cagaacgtcg agggcggcgg cgactacatc
    17341 ggcggcgact acgtcggtgg cgaccacttc ggtggtgact acgtcggcgg caacaaggcc
    17401 ggcacggtgc acggcaatca gggcgacacg gtccacggcg acaagcacga gggccgccga
    17461 tgagcgccga ggacgcgcgt acggatatcc cgcagcagaa cgacggggcg tccagcgagg
    17521 agccggagcc ccaggcagcg ggcgaggagc cacccgaggg cgatatcggc ttcgcggacc
    17581 cggacgaggg ggacttcgac gaggtagcgg cggagtacgc gctccacggc ggggagttcg
    17641 ccggtctgcc gttcggtcgt cagccgtacc cggtgatcgt cgctccgcgc gccaacatca
    17701 acaccggctc cgtgcacggc ggtcagcggg tggagaacca tggcggcacc accggaaccg
    17761 gcgggcggcg ggtcgaggcg cacgaggggc ccatctccgc ggtcgagatc ctcgacgccc
    17821 aggcggggtt cgcggaaccc gactggttcc ccgcggccct ggccgaactc gacagtcggc
    17881 tgctgttcct caccggtgag cccggtaccg gccgccgcac cgcggcgctc aatctgctgc
    17941 gccggcacag cggcggcagc atgaacctgc gggcggtcga cggcgatatg aacctcgcct
    18001 cctggcgccc gaagcaccgc gaatcccgtg gctatctggt ggacgggctg ctgcccgaat
    18061 accccctgaa gccggggatg gtgcgccatc tccagagcct tctgagcagg gccgatgcac
    18121 gcatggtggt ggtgctgccg gatgacccgg cactggtccg gcgcctgtcg cgcgagctgc
    18181 atgtcacgcc cgtccggtgt gcgccaccgg ccgcgcgggc ggtgttcgac gcccgcttcg
    18241 cggacgcggt gccggacccc tcggagcgcg cccggcggct ggccctcctg gaacccgggc
    18301 tgctggacga gctgctcgcc ccggagctgg tgccggccca agtggccgag ctggtggctg
    18361 cggtggcagc ggcggaggac ggcggaccgg acctcgccga catcgagaaa aggctgagct
    18421 tcctcgcgga gggtgaggtg ccggacctgc tcgcgcaact gcgggacgac gccgacggac
    18481 tcgccttcct cctcgcgacc tgcgtgttcg agggcctgga ccaccggatc gtgcgggagg
    18541 aggcggagcg gctccttgag ctggcggacg ggcggctcag ctccgtactg ccggagggcg
    18601 ccgacggctc cgacgaggac tggcggcgcg accgggagcg gaagccacgg cccaatccgc
    18661 agttcgtctt ccggcggtcg ctggacgaac tcctgcggac cgtacgggcc cagtgctccc
    18721 cccgggagat ccgctccaac tccggctaca cctacgccgt ggaggccgtg cgcttcaccc
    18781 gccaccggca ggcggaggcc gtgctgcggc atgtctggcg ggagtacgga cacctctccc
    18841 gcctgctgac cgagtggatg gcagacctca agaacgagca agagctgacc gaaccggtgg
    18901 gccgggtgat gggcctggcc gctggctggg gcgggggccg ccgagctctc cagcacatcg
    18961 gtaccctcgc cacgtcttcc cgtcggagca gccgcaccat cgccgcgtac gcgctgggca
    19021 tggcggccgg agatcccatc ctggcccgcg aggtcaaata ccgcctcagc ctgtggagcg
    19081 cgcagcagag ctggcaggtg cgctccaccg tcgcctacac ctgcggtgcg gacttcggcg
    19141 cctcccgtcc cgaggtggcc atgcggctgt tgcggaatgt gccccgcggc cagggtgacg
    19201 agcacgagcg caccgtggac cgggcggtcc gcgacgcgct gaacgatctg ttcgcctccg
    19261 gcagccaagc caccgtcttc cggcatctgg ccgaatgggc cgacggcgag gggcccttga
    19321 ccgatgtcgc gctccggacg ttgccccagc tgctccagaa caccccgtgg tgtcaggaac
    19381 agctggtcaa cgacggcgaa tatgcggctc agatcatcgg ccttgtccac cggacactga
    19441 acgacgagga gctgttcgtg gcgacctgca acgcggtgct ctggtggtgc cggatggccg
    19501 cgtggggtga tctgccgcgg acggccgtgg agaccctgct cagcgcgctc gcggcggact
    19561 tccggcacgg ggtgctccgt ctcttcgtcg tgatcgaccg ggctgacgtc cccgatctcg
    19621 ccggactcgg catcgcccgg gacgccctgc acacgtggcg gaacggcgag cagccatggc
    19681 agccggtgaa cggcagcacc cacccgaacg ggagaacgtc atgacgaccg acagcaacca
    19741 gcccgtctac gcccccgccg cacacgcccc ttggcgggag atcctgcggc accgctggtc
    19801 cggccgcctg gaccgggccc tggtgctgcg ggagcacagt ggcgcctacc gcgtactggg
    19861 ctcccggaag cgggcacctc tcagggcagc cgacgaggtg accgggcagg cgtcgtccgc
    19921 gccccggctg ctgggaggct acgacagtgc cttccacgtc cagctccacg agctgtcggg
    19981 gacccggagc gtcgcactgc ccaccgccta cggcacggag tcggtggacc tccgggtgct
    20041 gtggtgggtg cacgacccgg tggacgtggt gcgctcgcgc accacggacg gctgggaagc
    20101 ggtccgcaag gagctcgacc ggcggctgcg tcacctggag gacgcccacg cggccgacgg
    20161 acagaccctc ggcgcacccg agatcatgca ggagctggcc gcgccgcagc agctggacgg
    20221 cttcggcctc acctatcgcg tgacggatat ccgcggacag gaatcggagg gtgaactgcg
    20281 gctgggacaa cccggcgggg ccggtctgcc gtactcctgg accgcccatc ggcgtgagga
    20341 gttccggttc tgcgaggagg ccgtgcgcag cggcccggtg tcgctggcgg cgctctggct
    20401 ggtccggcac cccgaccagg tcagccaggt gctggactgg acggtgaacc accgtggcct
    20461 gctcaaggag gagaccgact ggcaggacga aatcgctgga ctcctgggcg agttgacgga
    20521 gcaggagagg caggaactct ccggactgct gcgggaccgc ctcgccgggc tggggcgccg
    20581 ggtgcccgca ccgtcggcac cgcaggaagc gccgtcggac aaggggcccg ggagccgcga
    20641 ggtgaacggc cactggcgcg ggacggcaaa ggagtggtcg gtgtgaggcg cacggcgctc
    20701 ccccgtcctt cggtgcgcct cgtgccgcag cggggtgcgc gggccggggc tgccgtggcg
    20761 cgccggcgcc ccgctccgcg ccggcaccgt cagccgcacc ggaccctgcg tgaccgccgt
    20821 gagccgggcg ccgctccggg ggcgccgcac ccggagactc tggcggcgat ggaacgcttc
    20881 ttggcggcca acggtgtgga gatcgcacgg gcggacacca aggccgcggt gctgctgggc
    20941 ttcatgggcg cggtgctcgg cgccttcatc acggtgaccc gcggcgccac cacacaccag
    21001 gccgccgcct cctggaaggc ggatgtgctc tggtggggcg cggtcaccac cgcgctgctg
    21061 gccatcgttt gctttgtctc cgccatcgcc ccccgacggc gcaggggacg gaaacccggc
    21121 ctggcgggcc ccggctactt cgaacacatc ggacggggag aggacggcga aggcctcagt
    21181 catgccttcg cccgtatcgc gcacgacccc accggcccgc tcctggactc cgtccggcgc
    21241 accagcgcga tcatccgctc caagtaccgc tggatcgaga cgggaaccgc gctgctgctg
    21301 gtggcccttc cgcagttcgc ggccgcgtta caaccggggt gaaggtgcgg accgttggcg
    21361 aacggagggg gaggctgtct cccccttgtc tacccctggg cggaggcccc cgcccagtcg
    21421 gtcagggcgc ggtggcgctc gatgcggcgg tccggcaggg acggtgtgcg ggtggcccag
    21481 gcgatatggc cgtcggggcg gatgaggatc tcccgtaccc cgtcgaggtc ggtgcggtgg
    21541 tcgtggtggg tgacggtcag ggcggtcacc cgggggcccc agcccggggt gacggtctgc
    21601 cgtagctgct cgtcgcccgc gaggtccagc aggacgaacc ggccgtgcgg gaggagctcg
    21661 tggacgcgga tcgccgcgga accgtccgcc gtcagggcga tatcgggcat ccgtcgtccc
    21721 gtcagggggt cggcgtcggc ggcggtgggc ggatagaccg tgtcgagcgc ggaaatccgt
    21781 ccggccagac ggcggttgac ctcctcgatg cccaggagtt ccgtcagcag cgtgcgtagc
    21841 gcggcggccg ggcgctgata cggggggagc agggtcagct ccatcagcag cgtctggacc
    21901 tcggtgttct cggtgaccgc ctgtccgacg ggatgccgct cggcgtggta gctgtcgagc
    21961 agtccgggcg gggcccagcc gttgatctcg gcggcgagtt tccagccgag gttcatcgcg
    22021 tcctggagtc cggtgttgag gccctgtccg gcggccggga agtggatatg ggcggcgtcg
    22081 ccggccagca ggacgcgtcc ggcccggtaa cgggcggcga ggcgggtggc gttgccgaac
    22141 cgcgacagcc aacggggccg cgccaccccg cagtcggtgc cgcagatatc caccagggag
    22201 ctgcggaact cctccggtgt cagcggttcg gtgga
//
