LOCUS       NZ_CP050976            29327 bp    DNA     linear   CON 06-JUN-2024
DEFINITION  Streptomyces sp. RPA4-5 chromosome.
ACCESSION   NZ_CP050976
VERSION     NZ_CP050976.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RPA4-5
  ORGANISM  Streptomyces sp. RPA4-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9051652)
  AUTHORS   Nicault,M., Bontemps,C., Tidjani,R., Gelhaye,E. and Leblond,P.
  TITLE     Mining the biosynthetic potential for specialized metabolism of a
            Streptomyces soil community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9051652)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72x/76x
            Sequencing Technology :: Oxford Nanopore GridION/Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012273495.1-RS_2024_06_06
            Annotation Date                   :: 06/06/2024 02:35:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,979
            CDSs (total)                      :: 7,887
            Genes (coding)                    :: 7,432
            CDSs (with protein)               :: 7,432
            Genes (RNA)                       :: 92
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 455
            CDSs (without protein)            :: 455
            Pseudo Genes (ambiguous residues) :: 0 of 455
            Pseudo Genes (frameshifted)       :: 276 of 455
            Pseudo Genes (incomplete)         :: 232 of 455
            Pseudo Genes (internal stop)      :: 23 of 455
            Pseudo Genes (multiple problems)  :: 71 of 455
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:36:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2331684
            Orig. end                         :: 2361011
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050976.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29327
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="ectoine"
                     /product="lanthipeptide-class-i"
                     /region_number="14"
                     /rules="ectoine_synt"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..29327
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="ectoine"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10417
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10417
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5417](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5417
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(<42..983)
                     /locus_tag="HEP86_RS10580"
                     /old_locus_tag="HEP86_10580"
                     /pseudo=""
     CDS             complement(<42..983)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008412167.1"
                     /locus_tag="HEP86_RS10580"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10580"
                     /product="SCO1860 family LAETG-anchored protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPRRLAATLVATALTAGPAVLLGAVPAHATGDHGPARGTADAVVL
                     RTGVNVGLLNKTLDVPLNVALNEVHAPASASKTALTVKLDGIDHGRPFSVLRADAATAR
                     ATADRRAAEGYANLVRAKVHLPGLPLLSVIEVQQVTAKAVCEAGARPRAEANVLGTVRV
                     LGQKVTLTAGGTTKVKVPGVGQVRLDLSKKNVTSKGAAATALDLDVSVNPLKLNVADVH
                     GRVTLAKATCTTPRGKAPEDNGSGGTSGGQTGGGTEPAGGKGTEATQTGSGTSTQNLAE
                     TGGSSATPYLAGGAGLLLAAGAGAMVFARRRRS"
     gene            complement(1271..2362)
                     /locus_tag="HEP86_RS10585"
                     /old_locus_tag="HEP86_10585"
     CDS             complement(1271..2362)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960017.1"
                     /locus_tag="HEP86_RS10585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10585"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_168483659.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2e-16, bitscore:
                     59.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEGAVLHLKGRVLVGPDDVRDELWVVGGRVTFDRPSMARDATTV
                     TGWALPGLVDAHCHVGLDAHGPVDAPTSEKQALTDRDAGTLLIRDAGSPSDTRWVDDRE
                     DLPRIIRAGRHIARTKRYIRNYAHEIEPEDLAAYVAQEARRGDGWVKLVGDWIDRSTGD
                     LEACWPRGAVEAAIAEAHRLGARVTAHCFAEDTLAPLVEAGIDCIEHATGLTEETIPLF
                     AERGVAIVPTLVNIATFPRLADGGAAKFPRWADHMRRLHDRRYDTVRAAYDAGVPVFAG
                     TDAGGSLAHGLVAEEVVELTRAGLPAVAALSATTWGARDWLGRPGLTEGAPADLVVYES
                     DPRADVRVLAAPRRVVLRGQVVG"
     misc_feature    2790..2807
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.47"
                     /tool="antismash"
     misc_feature    complement(2792..2807)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(2802..2817)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    2935..2947
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            2972..3538
                     /gene="ectA"
                     /locus_tag="HEP86_RS10590"
                     /old_locus_tag="HEP86_10590"
     CDS             2972..3538
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577188.1"
                     /locus_tag="HEP86_RS10590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10590"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_168478527.1"
                     /transl_table=11
                     /translation="MTAAQADHAGARSDFREFPEGFKLDTPRVEDGAAIWRIARDSKAL
                     DLNSSYSYLLWCRDFAATSVVARDAEGEPAAFITGYLRPERPETLVVWQVAVDDAHRGQ
                     GLAAALLDGLAARARDELGVRFVETTVTPDNTASNRLFASFAERHSVPLKSEVLFDAGL
                     FPEQGHEPEVLHLIGPFEPPARSGH"
     misc_feature    3010..3024
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.72"
                     /tool="antismash"
     gene            3678..4946
                     /gene="ectB"
                     /locus_tag="HEP86_RS10595"
                     /old_locus_tag="HEP86_10595"
     CDS             3678..4946
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-365). E-value: 3.8e-75.
                     Score: 244.9. Matches aSDomain:
                     nrpspksdomains_HEP86_RS10595_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="HEP86_RS10595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10595"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_168478528.1"
                     /sec_met_domain="Aminotran_3 (E-value: 7.8e-78, bitscore:
                     260.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRSWPTVFDRAQGSRMTDEDGHTY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGVTHGLDMSTVAKRAFLESFQNIILRPRD
                     LPYKVMFPGPTGANSVEAALKLARKVKGRESIVSFTNAFHGMSLGALAVTGNSMKRAGA
                     GIPLVHGTPMPFDNYLDGTYPDFLWFERLLEDQGSGLNTPAAVIVETVQGEGGINVARP
                     EWLRALSDLCERWDMLLIVDDIQMGCGRTGAFFSFEEAGIVPDIVTVSKSISGYGLPLA
                     LTLFKPELDIWEPGEHNGTFRGNNPAFVTAAATLDTYWADGQMEKQTLARGEIVEAHLK
                     AIAEEHPDAIAEYRGRGLVWGLECNDKPLANKIAARAFELGLLIETSGPESEVVKLLPA
                     LTTTPEELDEGLRVLARAVRDCA"
     aSDomain        3762..4772
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS10595_Aminotran_3.1"
                     /evalue="3.80E-75"
                     /label="HEP86_RS10595_Aminotran_3.1"
                     /locus_tag="HEP86_RS10595"
                     /protein_end="365"
                     /protein_start="28"
                     /score="244.9"
                     /tool="antismash"
                     /translation="FDRAQGSRMTDEDGHTYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGVTHGLDMSTVAKRAFLESFQNIILRPRDLPYKVMFPGPTGANSVEAALKLARKVKG
                     RESIVSFTNAFHGMSLGALAVTGNSMKRAGAGIPLVHGTPMPFDNYLDGTYPDFLWFER
                     LLEDQGSGLNTPAAVIVETVQGEGGINVARPEWLRALSDLCERWDMLLIVDDIQMGCGR
                     TGAFFSFEEAGIVPDIVTVSKSISGYGLPLALTLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAATLDTYWADGQMEKQTLARGEIVEAHLKAIAEEHPDAIAEYRGRGLVWGLECN"
     cand_cluster    4062..29327
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4062..29327
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[14061:19327](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      14062..19327
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
     gene            5001..5417
                     /locus_tag="HEP86_RS10600"
                     /old_locus_tag="HEP86_10600"
     CDS             5001..5417
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606340.1"
                     /locus_tag="HEP86_RS10600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10600"
                     /product="ectoine synthase"
                     /protein_id="WP_168478529.1"
                     /sec_met_domain="ectoine_synt (E-value: 2e-53, bitscore:
                     178.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVNAKSGTWESKRIVLAKERVGFSLHETTLY
                     AGTETSMWYANHIEAVLCVEGEAELTNDETGEKYTITPGTMYLLDGHEKHTMRIKEDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEPESEPETV"
     gene            5513..6412
                     /gene="thpD"
                     /locus_tag="HEP86_RS10605"
                     /old_locus_tag="HEP86_10605"
     CDS             5513..6412
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358305.1"
                     /locus_tag="HEP86_RS10605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10605"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_168478530.1"
                     /sec_met_domain="PhyH (E-value: 5.8e-36, bitscore: 123.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPERTADLYPTRGTAEVITPRKDPVVWSQPGTAGPFEPSELS
                     DFERDGFFAIGELLTPEEVAVYRAELDRLVLDPTMRADPRSIVEPKSQDVRTVFEVHKI
                     SEVFAKLVSDPRVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP
                     NMRTVSVSIALTENYDTNGGLMIMPGSHQHFVGCEGATPKDNYKRSLQMQDAGIPSDEV
                     LTKLADTHGVRLFTGQAGSATWFDCNAMHGSGDNITPYPRSNVFIVFNSVENEAVEPFA
                     APVRRPEYIGARDFAPVR"
     gene            complement(6530..7597)
                     /locus_tag="HEP86_RS10610"
                     /old_locus_tag="HEP86_10610"
     CDS             complement(6530..7597)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969934.1"
                     /locus_tag="HEP86_RS10610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10610"
                     /product="alkene reductase"
                     /protein_id="WP_168478531.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLAGTPLANRLVMAPMTRNRATAEGVPTPPMVRYYTQ
                     RASAGLIITEASQTEPVGRGYPLTPGLHTPEQVAGWRRVTDSVHAAGGKIFAQLWHGGR
                     IGHPVLLPDGLVPVAPSAVGAAGQGFTQDGPTDFVTPRELTDEEIHRTIDGFAAAARNA
                     LEAGFDGVELHGGNGYLIHQFLAPNTNLRTDAWGGSDEARARFAIEVVKAVAAEAGAHR
                     TGLRLSPGNPFNDIDEPAPEATYTAVVEAVAPLGLAYLHTCDVLDLELLARLRKRFGGT
                     FLLNPATEGRPTGPEELSLVEEGEADLLAYGALFLANPDLPRRLALGGPFNTPDRASFY
                     GGDDSGYVDYPALEA"
     gene            complement(7690..8751)
                     /locus_tag="HEP86_RS10615"
                     /old_locus_tag="HEP86_10615"
     CDS             complement(7690..8751)
                     /NRPS_PKS="Domain: Aminotran_5 (16-348). E-value: 1.7e-21.
                     Score: 68.5. Matches aSDomain:
                     nrpspksdomains_HEP86_RS10615_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606338.1"
                     /locus_tag="HEP86_RS10615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10615"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_168478532.1"
                     /sec_met_domain="Aminotran_5 (E-value: 5.2e-14, bitscore:
                     50.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRREPLGGAEFAPETTYLNSASSGLLPRRSADALRAALEESASY
                     GTMGRDYFAAATASRAAFARLLDVPAERVALGSSVAVQSAFVAATLPEGAEVLAPEGDF
                     SSLVNPLAARPGIKLRTVPLEALADAVRPGTALVAFSAVQSLDGRIADMAAVREAARAH
                     GARTYLDITQAAGWLPLPAADFDFVVAGAFKWLLCPRGATFMAFGGDYGRGAEWPAALH
                     AGWVAGEDIGASNYGLIQPAATARRFDEPYAHLSYIGAEQSLGLLEELGVETVHAHNTA
                     LADHYRAGLAERGLTPRPAPGSAIVSTPGIADAEDRAAAAGVRISVRGGLLRAAFHLYN
                     STDDVDRLLALLV"
     aSDomain        complement(7708..8703)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS10615_Aminotran_5.1"
                     /evalue="1.70E-21"
                     /label="HEP86_RS10615_Aminotran_5.1"
                     /locus_tag="HEP86_RS10615"
                     /protein_end="348"
                     /protein_start="16"
                     /score="68.5"
                     /tool="antismash"
                     /translation="TYLNSASSGLLPRRSADALRAALEESASYGTMGRDYFAAATASRA
                     AFARLLDVPAERVALGSSVAVQSAFVAATLPEGAEVLAPEGDFSSLVNPLAARPGIKLR
                     TVPLEALADAVRPGTALVAFSAVQSLDGRIADMAAVREAARAHGARTYLDITQAAGWLP
                     LPAADFDFVVAGAFKWLLCPRGATFMAFGGDYGRGAEWPAALHAGWVAGEDIGASNYGL
                     IQPAATARRFDEPYAHLSYIGAEQSLGLLEELGVETVHAHNTALADHYRAGLAERGLTP
                     RPAPGSAIVSTPGIADAEDRAAAAGVRISVRGGLLRAAFHLYNSTDDVDRL"
     gene            complement(8865..>9062)
                     /locus_tag="HEP86_RS10620"
                     /old_locus_tag="HEP86_10620"
                     /pseudo=""
     CDS             complement(8865..>9062)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091831.1"
                     /locus_tag="HEP86_RS10620"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10620"
                     /product="DsbA family oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="REASQLGATGVPFFVIDRRYGISDGQPAEVFREALERAYADGAEP
                     LGAAGDAGVCGDDGCAVPGK"
     gene            complement(9217..9855)
                     /locus_tag="HEP86_RS10625"
                     /old_locus_tag="HEP86_10625"
     CDS             complement(9217..9855)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761661.1"
                     /locus_tag="HEP86_RS10625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10625"
                     /product="HAD family phosphatase"
                     /protein_id="WP_323139112.1"
                     /sec_met_domain="HAD_2 (E-value: 2.5e-08, bitscore: 33.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTPYRGLILDFGGVLTTRMRLNGEAFEKSEGLEPGAYFHALEE
                     NPEGVAVYSALEVGEATQEDWNRVIGGILGIDPTDLMRRALANLRPEPQIVAAAQRARS
                     AGIKVAMLSNSFGTEPYNPYEDKGMWDGFFDAVVLSELEGVRKPSTRIYQRALDSLGLT
                     GPECVFVDDHAENLPPAEALGIRTVHHTTDPAATAKLLDSLLLGCTSVA"
     gene            10029..11246
                     /locus_tag="HEP86_RS10630"
                     /old_locus_tag="HEP86_10630"
     CDS             10029..11246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571579.1"
                     /locus_tag="HEP86_RS10630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10630"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_168478533.1"
                     /transl_table=11
                     /translation="MAIDGELFSIGQRIKWLRERRGMSQKTLGDFIDRSENWVYKIEHD
                     RMPVDRVSVLVALCQALRCSMEDLTSGYVSSIATGDAEHEHVPTIRQALSLPSSLLPLR
                     IAGVTADGFEESVTDAWKVYETQAEARYQDVGGRLPNLLRQGHAALRDANSEDEPAILR
                     QLISLYGLHQIWLRRVGEPTLARIAADRGLALADNAGDPALLAAAAWNLSCVLTSAGDV
                     ADSLELARQTIAQCKPADDASPEHWSAYGALHLQGAVAAVRATSPVAWDLYRGAQQAAK
                     KVGGDLNHWHTCFGPTNVAMHEVHLMAEEGDVSEALRVADSVQVNPELPLERRTRYLIE
                     VMNLNRVQRDDYATVHILGKLKKQSPEEIVFSPLVRQAVAELLKREKPLWRDDLREVAK
                     HVGFAA"
     misc_feature    11279..11288
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.26"
                     /tool="antismash"
     misc_feature    complement(11412..11430)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.41"
                     /tool="antismash"
     gene            11416..11580
                     /locus_tag="HEP86_RS10635"
                     /old_locus_tag="HEP86_10635"
     CDS             11416..11580
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS10635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_10635"
                     /product="hypothetical protein"
                     /protein_id="WP_168478534.1"
                     /transl_table=11
                     /translation="MSHTQAGRFTVPLDLCEGSAERTPLPLILTAEEAVDIHAQLSALI
                     AEKQGGGAA"
     gene            11765..12253
                     /locus_tag="HEP86_RS10640"
                     /old_locus_tag="HEP86_10640"
     CDS             11765..12253
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004933662.1"
                     /locus_tag="HEP86_RS10640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10640"
                     /product="ATP-binding protein"
                     /protein_id="WP_248001080.1"
                     /transl_table=11
                     /translation="MTATMTAPVLASPRMLPRTHDTMAACFAISPRGEHQAIPAQDVRR
                     VSAMRRLARARLRYCRLSALADDIALIVSELVTNAIAHSHGTDITMTLVLNHGLLRLEV
                     RDETARRPEIQQPADGAEHGRGLILVQAITEQCGGKWGTGPDGTSTWCTIPVPAEGDQ"
     gene            12485..13723
                     /gene="fxlM"
                     /locus_tag="HEP86_RS10645"
                     /old_locus_tag="HEP86_10645"
     CDS             12485..13723
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490583.1"
                     /locus_tag="HEP86_RS10645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10645"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_168478535.1"
                     /sec_met_domain="PCMT (E-value: 4.5e-37, bitscore: 126.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTNTTVEPDEATRLRNKVVDELCADGTMSSPEIEAAMRKVARHE
                     FAPEAPLEKAYDTYAAVITKTDEHGVQLSSVSAPQIQALMLEQARVRPGMRVLEIGSGG
                     LNAAYLAELVGEDGEVVTVDIDPVVTDRARRLLDEHGYGRVHVVTADAAEPLPDLGEVD
                     VVMVTAGAWDIPPAWTSQLKQGGRLVVPLRMRGLTRSVAFTRVSGEHGDYLESESAPIC
                     GFVPMQGSTAHREELLLVNGTPEIGLRFDDGLPADPHRLDNAVKTLRHELWTGVTIGLQ
                     ELLDTLQMTMAISLPGFCTMAVDDDLDTGLVAPVNKRFALAAVEDDTFAYLVTRRTEDN
                     KHVEYGVHALGPNAKQLADTIAGVLRDWEANRRGGPSPVIRVYPASTSDDQIPADRVID
                     KVHSRVSLSWPSA"
     gene            13776..13970
                     /gene="fxlA"
                     /locus_tag="HEP86_RS10650"
                     /old_locus_tag="HEP86_10650"
     CDS             13776..13970
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="HEP86_RS10650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10650"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_168478536.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.1e-16, bitscore:
                     59.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATLAPPAPLADLDDDDFAPLDVKVVIAEHPYGKLMCSTGDGC
                     GSTCATNSSACNSFVEDPA"
     gene            14062..17127
                     /locus_tag="HEP86_RS10655"
                     /old_locus_tag="HEP86_10655"
     CDS             14062..17127
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746441.1"
                     /locus_tag="HEP86_RS10655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10655"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_168478537.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.4e-199,
                     bitscore: 661.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.7e-15,
                     bitscore: 55.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.3e-09, bitscore:
                     36.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPRAVANYQWQGAAMLRATTSPGPADVPRTLNLDDVAATRGWLN
                     RVWQREEVRSALELATPVLSAAVEAVGQGKQSDPRHVRRTALSAASYLLRWQHRPTPLG
                     LFAGTAPLSVGPRASVRWRDKHRVAIRPDAEWITDIILRLQRSPELLKRLPLIANNAAR
                     TRGDRLVAPGPPADGYARLLAPVEISVRHARPVAAAMDAARTPITYLDLHTRLRDTFPQ
                     ATTEKIGALLGSLIEQQLLITSLWAPMTTVDAFQHLMRELEKHQADTVPDVRDLVHTLN
                     TVCEDVSAHQPVLFGTGVGAIAARMRDLSPVTPTPLLIDTALDGEVQLPQAVVAEVQVA
                     VAGLYRTTPQPYGYQHWRDYHRRFRARYGVGALVPVMDLVADSGLGLPAGYVGSERGPA
                     PKLLTDRDEVLLALVQQVLMDGHDELRLTDATIDALEKAAGSDERLFVPRVEVAFEVHA
                     PSTAALARGAFDVLLTSVPRPGSSMAGRFAHVLPPSQQDALAATYRGAPDALPTQLVFP
                     PRRRRNENVTRTPRLLPHVIELSGHQRADETTIPLADIAVTADARTFHLVQLSTGSHID
                     VRVLHALEAGTQTPPLARFLAEVATARYAAYKPFDFGAAARLPFLPRVRYCRTILTQAR
                     WLLSAEDLPGRTAPATQWDQAFDAWRGRLRVPNHVAMIEYDQRLPLDLTHPVHRRVLRA
                     ALDNARRLDLREVPDSDAHGWIGRAHEVWLSLGLPQPEDANAPRPLPVTPAATERHLPG
                     AGDILHAQLHAHPRRYDEILSRHLPNLLAAFGDTPPIWWFTRHREMARPDADQHLDLTL
                     HLPQGAYGTSAEHAHTWADTLHALGLASGLVLAAYQPQTGRFGHAAAMDAAHQVFAADS
                     AAALAQIQLTERTDVFAPQALAAASALSLVTHLAPSAAEAEEWLVRNLPQGKGRLDRAL
                     RNQVLELAAPERASALAALPGGSQVAEAWRARAAALDVYRNALARERDPLAVARSLLHQ
                     HHVRALGVSPSTEATTLRLVRSAALQHRMTSR"
     misc_feature    14320..14322
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14521..14523
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        14530..14805
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HEP86_RS10655_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="9.40E-18"
                     /identifier="RREFam001.1"
                     /label="HEP86_RS10655"
                     /locus_tag="HEP86_RS10655"
                     /protein_end="248"
                     /protein_start="156"
                     /score="55.7"
                     /tool="antismash"
                     /translation="IANNAARTRGDRLVAPGPPADGYARLLAPVEISVRHARPVAAAMD
                     AARTPITYLDLHTRLRDTFPQATTEKIGALLGSLIEQQLLITSLWAP"
     gene            17124..18356
                     /locus_tag="HEP86_RS10660"
                     /old_locus_tag="HEP86_10660"
     CDS             17124..18356
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746440.1"
                     /locus_tag="HEP86_RS10660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10660"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_168478538.1"
                     /sec_met_domain="LANC_like (E-value: 6.4e-35, bitscore:
                     119.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTATAGTLLERYASHLADPSPPPPNQPWAVQSLADGAAGISL
                     LHIELAGRYGGSWRPAHRWVTAAAAGHISAADTTGLFLGAPAVGFLLTAVPPPFQHLYD
                     AARRTLHQHITALAHRRVDAALARISNRDLPAFAEYDLFYGLTGIGSYLLRTDPQGAAL
                     ERVLRYLVALTRPLAPGGRGLPGWWVRHDPARGESPLFPGGHGNFGAAHGITGPLLLLA
                     QALRRGITVSGHQEAMLTICEYLDAWCQYGPSGPWWPEHVSCRDLERGCPHHGAPARPS
                     WCYGTAGIARAGQLAGIALRAPDLQAFYENALYQALTDPVQLAHVTDTGLCHGWAGIYQ
                     TAARAAADARDLRLQALPQRLGDTLAAQAAPGVTPVKGLLNGDAGTALALTTLASQQAP
                     TTGWDACLLIN"
     gene            18338..19327
                     /locus_tag="HEP86_RS10665"
                     /old_locus_tag="HEP86_10665"
     CDS             18338..19327
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490580.1"
                     /locus_tag="HEP86_RS10665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10665"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_168478539.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-33, bitscore:
                     115.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDQLIQADPSPIQRAVLAVLTGLPIADAAHQHRMDPVILSDAV
                     AVYDQAGREALARHASTTDWWQVYLHFTDWANADTTFTTSVLPILWEAEAAGTIDGWWY
                     TRKHPCWRLRLHLRPKTGTKLPVGDGFDRLVADGHLQRWWPGIYEPETPVFGGAAGMTA
                     AHALFVTDSREAQQLRQRDDLAVGPRELSVLLCTIMMRAAGLEWYEQGDVWHRVITSEH
                     RSAVGDVPADRLNARAQEIRPLLFADSDALLRSGGPLEPVAEWAAAFHRTGQALGHAVQ
                     SGTLDRGLREVLSYHVLFHWNRLGLSMRGQSVLAWAARAAILHNESGT"
     gene            19562..20224
                     /locus_tag="HEP86_RS10670"
                     /old_locus_tag="HEP86_10670"
     CDS             19562..20224
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485927.1"
                     /locus_tag="HEP86_RS10670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10670"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_168478540.1"
                     /transl_table=11
                     /translation="MPARHDIDAERELWDTFAESTKDKVFESESVFCWTQYAGHGPGPE
                     LLGNPTTALEIGCGTGRALAYLTQQGVKTTGVDLSPVMVKHTSERWGPLGAQFICAEVL
                     DHLSNSTERYDTVYSIFGAAWFTDPAKLFPLIAERLNPGGVLAFSHPPAIPGAYGPQGM
                     YKGGFAGKAMFTYRYSYTPRKWANLLLRSGFKDADVQILDAPKPGHIGTLIVRAVAD"
     gene            20406..21110
                     /locus_tag="HEP86_RS10675"
                     /old_locus_tag="HEP86_10675"
     CDS             20406..21110
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091833.1"
                     /locus_tag="HEP86_RS10675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10675"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_168478541.1"
                     /transl_table=11
                     /translation="MTSSQGFLGFWETAGSAKTFTHPLDPALLDAYVPRSARVLDYGCG
                     YGRLTAELAGSGYRAVRGVDVSAALIARGKREHPELELLHCPGFPLPFGDGAFDAALLF
                     AVLTCVPRDADQTAIVGELGRLVRPGGVLYLSDVPLQGDALNRERYARFSARYGTYGVF
                     ETPDGGVFRHHPPERLRGLVREAGFSVVKEREGSVATLDGQTADRLQLIARRDPVPPEP
                     VPPGVSPGPATG"
     gene            complement(21037..21600)
                     /locus_tag="HEP86_RS10680"
                     /old_locus_tag="HEP86_10680"
     CDS             complement(21037..21600)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536869.1"
                     /locus_tag="HEP86_RS10680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10680"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_168478542.1"
                     /transl_table=11
                     /translation="MRPAPDAALQVRAATAADLPAIAALHTGARAAYHRARFPDAPFDV
                     VAERARRHDAWLRDLDRGDTPALCAARHGTVVGAASYRHRADHHRPAVTLHQLHVDPGH
                     WGTGVGRALHGACLRAWRTAGFSRAVLDVLWHNHRARAFYTRLGWRPDPDRRPAPDATH
                     LTLWLDLATPPAAPAPAAPDPAGR"
     misc_feature    complement(21430..21432)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21606..23156)
                     /locus_tag="HEP86_RS10685"
                     /old_locus_tag="HEP86_10685"
     CDS             complement(21606..23156)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661350.1"
                     /locus_tag="HEP86_RS10685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10685"
                     /product="aldehyde dehydrogenase (NADP(+))"
                     /protein_id="WP_168478543.1"
                     /sec_met_domain="Aldedh (E-value: 2.8e-41, bitscore: 140.4,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAATAAAPVWSVDPRTGKQREQVAVEATADEVDTAVRTAHAARGA
                     LADRTVRAALLRRSADLLDEAGEAVIEAADAETALGPGRLTGELARTTYQLRAFADLVE
                     DGAFLDVLIDHADPGLTPPRPDLRRYKIPLGPVAVYAASNFPLAFSVPGGDTASALAAG
                     CPVVVKAHPDHPATSELCAALLHRAAREVGLPEGVVNLVHGFQAGIDLVRHPLISAAGF
                     TGSVRGGRALYDAAASRPHPIPFHGELGSLNPVVITEAAAAERAEQIGAGLAGSMTLGV
                     GQFCVKPGLVLAPGGETGDRLLTALTAAVSDTEAGVLLDHRMREAFLDGVRTRAALPGV
                     HAPVTPGAGSEHTVSAGFLAVPAAHLAAEGPHDLLLEECFGPVTVVARYADEAEIGAVL
                     ARLPGNLSATLQLGDAESAGTDAAGRGARLLAEVTPLAGRVVVNGWPTGVAVAPAQHHG
                     GPYPATTSTSTSVGGSAVERWLRPVAYQDTPPALLPPELHEDNPLGLPRRVDGRAEGV"
     gene            23295..24065
                     /locus_tag="HEP86_RS10690"
                     /old_locus_tag="HEP86_10690"
     CDS             23295..24065
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381154.1"
                     /locus_tag="HEP86_RS10690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10690"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_168478544.1"
                     /transl_table=11
                     /translation="MSAAETGGSQVKSAVRTVELLEYFAGRPGMHSLASVQEAVGYPKS
                     SLYMLLRTLADLGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAAARPTLDRLSDDTT
                     ETIHLARLDGTNVVCLATRQSQHSLRPFTRVGRRLPAHSTSLGKALLATYTDEQVRAML
                     PPALAPLTEHTLTDREQLIEELHAVREQGYAVDREESTLGLRCFGVAIPYRTPARDAIS
                     CSVPVARLAPGREQMIKEALFDARDRLTLATRRL"
     gene            24416..25686
                     /locus_tag="HEP86_RS10695"
                     /old_locus_tag="HEP86_10695"
                     /pseudo=""
     CDS             24416..25686
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091838.1"
                     /locus_tag="HEP86_RS10695"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10695"
                     /product="histidine kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRRWVHLVLGGALLMPFFLLTSVVVPLFADGANPFLDVGWQFVA
                     FGGALPLAALAALLFPLLRPLEVAAVRSLCGVPAERLAEGPAVSWAARRRTALWFVAHL
                     LAGGIVSGMTLSAPPAAVVLLLLPFADPLRHTALPDTFHGVLGPLAGLALLALVVGTAW
                     GAGALLGRAAPVLLGPTPADRLAAAERRAAELASRNRLARDLHDAVGHALSAVTLQAGA
                     ARRVLDTDPEFARRALAAIEETTRDAVAELDTVLGLLREEDSSDPAAPAPTLNGLEALL
                     GRTRAAGVPVEATVEGPCAGLAPVISREAYRIVQEGLSNALRHAGPVPVRLHLGVREGE
                     LLIRVENPVAGTGAGAAGARGPGRVGDAGCGGSPSAHGCWAVRRRRRNGTAYGGSRPGY
                     H"
     gene            25787..26497
                     /locus_tag="HEP86_RS10700"
                     /old_locus_tag="HEP86_10700"
     CDS             25787..26497
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606329.1"
                     /locus_tag="HEP86_RS10700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10700"
                     /product="response regulator transcription factor"
                     /protein_id="WP_168478545.1"
                     /transl_table=11
                     /translation="MTTTQDDDQRGQHPDAPRPLRIMLADDEQMVRSALRAILGAESDM
                     EVVGEAATGAEAVPLIRELRPDIVLMDVRMPEIDGIRATEQVLAGMDRPPRIIVVTTFE
                     NDAYVYDALRAGASGFLLKRSGAEDLVQAVRLVARSDSLLFPAAVRQLAARHAAQRAAD
                     DAVRTLRARLSERERAVLRLMTAGMTNAEIADRLGVGPATVKTHVAGVLAKLGVRDRTQ
                     AVIAAYECGFVRPG"
     gene            complement(26537..27505)
                     /locus_tag="HEP86_RS10705"
                     /old_locus_tag="HEP86_10705"
     CDS             complement(26537..27505)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960033.1"
                     /locus_tag="HEP86_RS10705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10705"
                     /product="5-dehydro-4-deoxyglucarate dehydratase"
                     /protein_id="WP_282189746.1"
                     /transl_table=11
                     /translation="MTSAPPPATVGRQQRRLTDRLDGPLFFPVTAYGPDRAPDPAAFRA
                     HVRDGIDAGAAAVFACCGTGEFHALTPGEFADCVAAAVEEAAGRVPVLAGTGYGTALAV
                     QCAELAHAAGADGLLALPPYLVIPGQQGLLTHYTELAAATPLPVIVYQRDNAVFAPATV
                     AALARTPGIIGLKDGVGDLDLLQRIISTVRTEAPEENFRYFNGLPTAELTAPAYRALGV
                     HPYSSAVFAFAPEIALAFHRALHTGDDTTVQRLLDGFYRPLAELRNQGHGYAVSLVKAG
                     VRLRGRDVGPVRPPLSEPSSAHVKELARLVERGLGLVGEGG"
     gene            27746..28564
                     /locus_tag="HEP86_RS10710"
                     /old_locus_tag="HEP86_10710"
     CDS             27746..28564
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (57-175). E-value:
                     2.2e-09. Score: 28.7. Matches aSDomain:
                     nrpspksdomains_HEP86_RS10710_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091841.1"
                     /locus_tag="HEP86_RS10710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10710"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_168478547.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.5e-05,
                     bitscore: 22.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPRTVLLTGAAGGVGTLMRELLPPYGYRLRLFDRRTIETTDGE
                     PDAITAELADTVALRAAVDGVDAIVHLAGISLEAPFEQILRANIEGTYRLYEAARAAGV
                     RRVVFASSNHAVGFTPRPADGSGAIPVGTPRRPDTYYGLSKGFGEDLASLYWDLHGIET
                     VSVRIGSCCPEPTSVRMLSIWLSPADCARLLDAALTAPGVGHTVVYGSSANTRLWWDLS
                     TARALGYTPRDDSEPYAAELIAAQGALDPGNPAHAHLGGSFCTDPPRWPH"
     CDS_motif       27761..27802
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEP86_RS10710_0001"
                     /evalue="3.40E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="HEP86_RS10710"
                     /protein_end="19"
                     /protein_start="5"
                     /score="6.9"
                     /tool="antismash"
                     /translation="TVLLTGAAGGVGTL"
     aSDomain        27917..28270
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS10710_NAD_binding_4.1"
                     /evalue="2.20E-09"
                     /label="HEP86_RS10710_NAD_binding_4.1"
                     /locus_tag="HEP86_RS10710"
                     /protein_end="175"
                     /protein_start="57"
                     /score="28.7"
                     /tool="antismash"
                     /translation="ALRAAVDGVDAIVHLAGISLEAPFEQILRANIEGTYRLYEAARAA
                     GVRRVVFASSNHAVGFTPRPADGSGAIPVGTPRRPDTYYGLSKGFGEDLASLYWDLHGI
                     ETVSVRIGSCCPEP"
     gene            28681..28953
                     /locus_tag="HEP86_RS10715"
                     /old_locus_tag="HEP86_10715"
     CDS             28681..28953
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960164.1"
                     /locus_tag="HEP86_RS10715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_10715"
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_168478548.1"
                     /transl_table=11
                     /translation="MGIVSWLVLGLIAGVIAKVLLPGRDPGGVIGTTLIGIVGSFIGGW
                     LSTKILHRPIPKDFGEPSMWVSSIAGALVLLIAYRLLFGNSRERR"
     misc_feature    29151..29166
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.24"
                     /tool="antismash"
ORIGIN
        1 cgcggtgtac ggggtcggtc agccgcggcc tcgggtgcgg cgctgcggcg ccggcgggcg
       61 aagaccatcg cccccgcgcc cgcggcgagc agcagcccgg cgccgccggc gaggtacggg
      121 gtggccgagc tgccgccggt ctccgcgagg ttctgggtgc tggtcccgga gcccgtctgc
      181 gtcgcctcgg tgcccttgcc gccggccggc tcggtgccgc cgccggtctg accgccgctg
      241 gtgccgccgg agccgttgtc ctcgggcgcc ttgccgcgcg gcgtggtgca ggtggccttg
      301 gccagcgtga cccggccgtg cacgtcggcg acgttcagct tcagcgggtt gacggagaca
      361 tcgaggtcga gggcggtggc cgcggcgccc ttggacgtca cgttcttctt ggacaggtcg
      421 agccgcacct ggcccacccc cggcaccttg accttggtcg tgccgcccgc ggtgagcgtg
      481 accttctgcc ccaggacgcg cacggtgccc agcacgttcg cctccgcgcg gggccgcgcg
      541 cccgcctcgc agaccgcctt ggcggtgacc tgctggacct cgatcacgga gagcagcggc
      601 agaccgggca gatgcacctt ggcccggacg aggttggcgt agccctcggc ggcgcggcgg
      661 tcggcggtgg cccgtgcggt ggcggcgtcg gcgcgcagca cgctgaacgg ccggccgtgg
      721 tcgatgccgt cgagcttgac ggtgagcgcg gtcttgctgg ccgaggccgg ggcgtgcacc
      781 tcgttgaggg cgacgttcag cgggacatcg agcgtcttgt tgagcagccc gacgttcacg
      841 ccggtgcgca gcacgaccgc gtcggcggtg ccgcgggccg ggccatggtc tccggtggca
      901 tgcgcgggga cggcgccgag gaggacggcg ggaccggccg tgagcgcggt ggcgacgagg
      961 gtcgcggcga ggcgtcgggg catgccgaag gagctggtgg gactggtgga cacgtgtgtg
     1021 gaaccctcac aggagaaatg gagccgccgg ccgcgccaat gggggacatc gcgcgggccg
     1081 acggcatcga cccgcacatc gtgtccgcac cgagggtgaa cgggcagcca cgtggcgtca
     1141 gttcatccca atgggtggtt tccgtgcctg tattcgattc ctgcgacacg gggcaccacc
     1201 ggcgccccag ccgccccacc tcccgggtga cccgcgttga ccgcgcaggt tcaccgggtc
     1261 gccccggcgg ctaccccacg acctgccccc gcagcaccac ccggcgcggc gccgccagca
     1321 cccggacgtc cgcgcgcgga tcgctctcgt agaccaccag gtccgccggg gcgccctcgg
     1381 tgaggccggg gcggcccagc cagtcccggg cgccccaggt ggtcgcggag agggccgcca
     1441 cggcgggcag accggctcgg gtcagctcga cgacctcctc ggcgaccaga ccgtgggcga
     1501 gcgagccgcc ggcgtccgta ccggcgaaga cgggcactcc ggcgtcgtag gccgcccgga
     1561 cggtgtcgta gcggcggtcg tgcaggcgcc gcatgtggtc cgcccagcgc gggaacttcg
     1621 ccgcgccgcc gtccgcgagc cgcgggaagg tggcgatgtt gacgagcgtg gggacgatgg
     1681 ccacgccgcg ctcggcgaac agcgggatgg tctcctcggt gagcccggtg gcgtgctcga
     1741 tgcagtcgat accggcctcg acgagcggag cgagggtgtc ctcggcgaag cagtgcgcgg
     1801 tcacccgggc gccgagacgg tgggcctcgg cgatggcggc ctcgaccgct ccgcggggcc
     1861 agcaggcctc caggtcgccc gtggagcggt cgatccagtc gccgacgagc ttgacccagc
     1921 cgtcgccgcg gcgggcctcc tgggcgacat aggcggccag gtcctccggc tcgatctcgt
     1981 gcgcgtagtt gcggatgtag cgcttggtac gggcgatgtg gcggccggcg cggatgatcc
     2041 gcggcaggtc ctcgcggtcg tcgacccagc gggtgtcgga gggggatccg gcgtcgcgga
     2101 tcagcagggt gccggcgtca cggtcggtga gcgcctgctt ttcgctggtg ggggcgtcca
     2161 ccgggccgtg ggcgtccagg cccacatggc agtgggcgtc gaccaggccc ggcagggccc
     2221 agcccgtcac cgtggtggca tcccgtgcca tcgatggccg gtcgaaggtc acccggccgc
     2281 cgaccaccca cagctcgtcg cgcacgtcgt ccggtccgac gaggaccctc cccttgaggt
     2341 gcagcaccgc accttcactc atggacgtca taccggcact gtaggcggcg cggtacggcg
     2401 ggtggccggg gcggtcgcgc cggttcgcac ggccggcttt ccccgcccgt ttccgggacg
     2461 ccgggcgccc cgccggactt tccgccggaa cttttttccg tgcactctcc gtgtggcttc
     2521 cgccacccgc gccgcaccgt tctccgtgtg ttcccggcga ctctgcgtac gtttcacgcg
     2581 gtcttccggg agatcgcctc acgcatgttc ccgcgggtct tgtcacggtc ttgccgcgca
     2641 ggtttccatg ggcctgcgcc cggccttccg gcggcgaatt cccaatttct tagaagtaca
     2701 gcttcccgta ttcttctgcc cgcttttccg cacctcaaac gccaagattt cgctagtggc
     2761 aagtaccgta attcggacgg atctcatggg tgttacggag ctgtgaccga ctacacaacg
     2821 tgtccatttc gccccgaaca tcccggtcaa atcggcacat cttgcggtgg catcgcgcac
     2881 ccgggcgccc cgcgcgataa cacaccctgg ccgcttccgt aacccctgcc cacgatgcaa
     2941 tttccatttt ccctaggtaa atttaattcc catgaccgcc gcacaagcag accatgccgg
     3001 tgcccgaagc gatttcagag aatttccgga gggcttcaag ctcgacaccc cacgcgtgga
     3061 ggacggagcc gcgatctggc gcatcgcccg cgactcgaag gcgctggatc tcaactcctc
     3121 gtacagctac ctcctgtggt gtcgcgactt cgccgccacc tccgtagtcg cacgcgacgc
     3181 ggagggcgag ccggccgcct tcatcaccgg atacctccgc ccggaacgcc cggagaccct
     3241 cgtcgtctgg caggtcgccg tcgacgacgc gcaccgcggg cagggactgg cggccgcact
     3301 cctggacggg ctcgccgccc gggccaggga cgagctgggc gtacgtttcg tcgagaccac
     3361 cgtgaccccc gacaacaccg catccaaccg gttgttcgcg tccttcgccg agcggcactc
     3421 agtgccgctc aagagcgagg tgctctttga cgcagggctg ttcccggagc agggccacga
     3481 gccggaggtg ctgcacctca tcggcccgtt cgagccaccg gcccgctcgg ggcactgacg
     3541 cacccaggac aggaccgcgc gacgacggcg ccgcagcggt caggcggaag ccggcacaca
     3601 ccccgtgaca cggccggtac cgcccagcac ccaacagact tcctcatcct tcgccactca
     3661 tctcccagga gcatgctgtg accatcaccc agcccgatct gagcgtcttc gagaccgtgg
     3721 agtcggaggt gcgcagctac tgccgtagct ggcccaccgt cttcgaccgt gcgcagggca
     3781 gccgcatgac cgacgaggac ggccacacct acctcgactt cttcgccggc gccgggtcac
     3841 tcaactacgg ccacaacaac cccgtcctga aacgcgccct gatcgactac atcgagcggg
     3901 acggcgtcac ccacggcctg gacatgtcca ccgtggccaa gcgggccttc ctggagtcgt
     3961 tccagaacat catcctgcgg ccccgtgacc tgccctacaa ggtcatgttc ccgggcccga
     4021 cgggcgccaa ctccgtcgag gccgcgctga agctggcccg taaggtcaag ggccgcgagt
     4081 cgatcgtgtc cttcaccaac gccttccacg gcatgtcgct gggcgccctc gccgtcaccg
     4141 gtaactccat gaagcgggcc ggcgccggta tcccgctggt gcacggcacc ccgatgccgt
     4201 tcgacaacta cctcgacggc acctacccgg acttcctgtg gttcgagcgg ctgctggagg
     4261 accagggctc cggtctgaac acccccgccg ccgtgatcgt cgagacggtc cagggcgagg
     4321 gcggcatcaa cgtcgcccgt cccgagtggc tgcgcgccct gtccgacctg tgcgagcgct
     4381 gggacatgct gctcatcgtc gacgacatcc agatgggctg cggccgcacg ggtgccttct
     4441 tctccttcga ggaggcgggc atcgtgccgg acatcgtcac cgtctcgaag tccatcagcg
     4501 gctacggcct gccgctcgcg ctcaccctgt tcaagcctga gctggacatc tgggagccgg
     4561 gcgagcacaa cggcaccttc cgcggcaaca acccggcctt cgtgaccgcc gccgcgacgc
     4621 tggacaccta ctgggccgac ggccagatgg agaagcagac gctcgcccgc ggtgagatcg
     4681 tcgaagcgca cctgaaggcc atcgccgagg agcacccgga cgccatcgcc gagtaccgcg
     4741 gccgcggtct ggtgtggggc ctggagtgca acgacaagcc cctggccaac aagatcgcgg
     4801 cccgcgcctt cgagctgggt ctgctgatcg agacctccgg cccggagagc gaggtcgtca
     4861 aactgctccc cgcactgacg accacccccg aggaactgga cgagggactc cgcgtcctcg
     4921 cccgcgcggt ccgcgactgc gcctgatcgg cccagcggcc ccagagatcc ttaccgttcc
     4981 acagaaaggc accgagcacc gtgatcgtcc gatccttcaa ggacatcgaa ggcaccgacc
     5041 gccacgtcaa cgccaagtcc ggcacctggg agagcaagcg catcgtgctc gccaaggagc
     5101 gcgtcggctt ctcgctgcac gagaccacgc tgtacgccgg gaccgagacg tcgatgtggt
     5161 acgcgaacca catcgaagcc gtactctgcg tagagggtga ggccgagctc acgaacgatg
     5221 agaccggcga gaaatacacc atcacgccgg gcacgatgta cctgctcgac gggcacgaga
     5281 agcacaccat gcggatcaag gaggacttcc gctgcgtgtg tgtcttcaac ccgcccgtca
     5341 ccggccgcga ggaccacgac gagaacgggg tctacccgct tctcaccgaa ccggagtctg
     5401 agcccgaaac ggtctgaggc gccgcccgcc cgctgccccg tccggcagcg cccaggaggc
     5461 acgcacacgc acgtaagcca gattccgtac gagaggagag gaaggcaaca ccatgaccac
     5521 cgcacccgag cgcaccgccg acctgtaccc gacccgtggg accgctgagg tcatcacccc
     5581 gcggaaggac ccggtggtgt ggtcgcagcc cggaacggcc ggccccttcg agccgtccga
     5641 gctgagcgac ttcgaacgcg acggcttttt cgccatcggg gaactgctca cgccggaaga
     5701 agtcgcggtg taccgcgccg aactggaccg gctggtgctc gacccgacga tgcgcgccga
     5761 cccgcgctcc atcgtcgagc cgaagtcaca ggacgtacgg accgtgttcg aggtgcacaa
     5821 gatcagcgag gtgttcgcca aactggtctc cgatccgcgg gtggtcggac gggcccgcca
     5881 gatcctcggc tcggacgtgt atgtccatca gtcgcggatc aatgtgaagc cgggcttcgg
     5941 tgcctccggc ttctactggc actccgactt cgagacctgg cacgccgagg acgggctgcc
     6001 gaatatgcgc accgtgtcgg tctcgatcgc gctgacggag aactacgaca ccaacggcgg
     6061 cttgatgatc atgcccggct cacaccagca cttcgtgggc tgcgagggcg cgacgccgaa
     6121 ggacaattac aagcggtcac tccagatgca ggacgcgggc atcccgtcgg acgaggtgct
     6181 gacgaagctg gcggacacgc acggggtccg cctcttcacg ggtcaggccg gctcggcgac
     6241 gtggttcgac tgcaacgcca tgcacggctc gggcgacaac atcacgccct acccccgcag
     6301 caatgtcttc atcgtcttca acagcgtgga gaacgaagcg gtggagccgt tcgcggcacc
     6361 ggtccggcgc ccggaataca tcggggcccg cgacttcgct ccggtgcgtt aggggacgtt
     6421 cgcaccggtg gcgcggccgc cgcacagcag gtctgtgcgg cggccgcgcc gtgttgtgcg
     6481 gccggtgcgc ggggccccgc cggggcggcc cgcaccggcg gacggctcct caggcctcca
     6541 gcgccgggta gtcgacgtag ccggagtcgt caccgccgta gaagctcgcc cggtccgggg
     6601 tgttgaaggg gccgccgagc gccagccgcc ggggcagatc ggggttggcg aggaacagcg
     6661 cgccgtacgc cagcagatcg gcctcgccct cctcgacgag cgacagctcc tcgggaccgg
     6721 tgggccggcc ttcggtggcc gggttgagca ggaacgtccc gccgaagcgc ttgcgcagcc
     6781 gggccagcag ctccagatcg agcacatcgc aggtgtgcag ataggccagg cccagcgggg
     6841 cgacggcctc gaccacggcg gtgtaggtgg cctcgggcgc gggctcgtcg atgtcgttga
     6901 aggggttgcc gggcgacagc cggagaccgg tgcggtgcgc accggcctcg gccgcgacgg
     6961 ccttgacgac ctcgatggcg aagcgggcgc gggcctcgtc ggagccgccc caggcatcgg
     7021 tccgcaggtt ggtgttgggc gccaggaact ggtggatcag atagccgttc ccgccatgga
     7081 gctccacacc gtcgaacccg gcctccaggg cgttgcgggc cgcggccgcg aagccgtcga
     7141 tggtccgatg gatctcctcg tcggtcagct cgcgcggggt gacgaagtcc gtcgggccgt
     7201 cctgggtgaa gccctggccg gccgcgccga ccgcggaggg cgcgacgggc accaggccgt
     7261 cgggcagcag caccgggtga ccgatgcggc cgccgtgcca cagctgggcg aagatcttgc
     7321 cgcccgcggc gtgcacggag tcggtgaccc ggcgccatcc ggcgacctgc tccggggtgt
     7381 gcagtccggg ggtgagcggg tagccacggc cgaccggctc ggtctgcgag gcctcggtga
     7441 tgatgagtcc ggcggaggcc cgctgggtgt agtagcggac catcggcggg gtcgggacgc
     7501 cctcggcggt ggcgcggttg cgggtcatcg gggccatgac gaggcggttg gcgagcgggg
     7561 tgccggcgag gtctatcggg tcgaacgcgg tggtcattga gggcctttcc actgctaccg
     7621 gaacaagatc gtttcccatt acaccagctg ctccaacgcg ccgccctccc cctgttcccc
     7681 gggccgccgt tacaccagca gggccagcaa ccggtccacg tcatccgtcg agttgtagag
     7741 gtggaaggcc gcgcggagca gcccgccgcg caccgagatc cgcacccccg ccgcggcggc
     7801 ccggtcctcc gcgtccgcga tcccgggggt ggagacgatc gccgaaccgg gcgcgggccg
     7861 cggcgtcaga ccccgctcgg ccagccccgc gcggtagtgg tcggcgagcg cggtgttgtg
     7921 ggcgtggacg gtctccacgc ccagctcctc caggaggccg agggactgct cggcgccgat
     7981 gtaggagagg tgcgcatacg gttcgtcgaa gcgccgggcg gtggcggccg gctggatcag
     8041 cccgtagttg gacgcgccga tgtcctcccc cgcgacccag cccgcgtgca gcgcggccgg
     8101 ccactccgcg ccccgcccgt agtccccgcc gaacgccatg aaggtcgccc cgcgcggaca
     8161 cagcagccac ttgaacgccc cggcgacgac gaagtcgaag tcggccgcgg gcagcggcag
     8221 ccagccggcg gcctgggtga tgtcgaggta ggtgcgcgcc ccgtgggccc gggcggcctc
     8281 gcgtaccgcc gccatatcgg cgatccggcc gtccagcgac tgcacggcgc tgaaggcgac
     8341 cagcgcggtg ccggggcgca cggcgtcggc gagcgcctcc agcggcacgg tgcgcagctt
     8401 gatgcccggg cgggcggcga gcggattgac cagggagctg aagtcgccct cgggggccag
     8461 cacttcggca ccctccggga gcgtggcggc gacgaacgcg gactgcaccg cgaccgaact
     8521 gcccagcgcg acccgctcgg cgggcacgtc cagcagccgg gcgaaggcgg cacgggaggc
     8581 ggtggcggcg gcgaagtagt cgcggcccat ggttccgtag gaggcggact cctccagggc
     8641 cgcgcgcagg gcgtcggcac tgcgccgcgg gagcagtccg ctggaggcgg agttcagata
     8701 ggtcgtctcg ggcgcgaatt cggccccgcc gagtggctca cgtcgatgca tgtccccact
     8761 ctgctccgcc cctcgtgccc cgtccatggc gaatccgctt ggccgacccg caacagttcc
     8821 ttatcgccgc aggtcacacc gggcgcaggc ggaccgtccc cctctcactt cccgggcacg
     8881 gcgcagccgt cgtccccgca caccccggcg tccccggccg ccccgagcgg ctccgccccg
     8941 tcggcgtacg cacgctccag ggcctcccgg aagacctcgg cgggctgccc gtcggagatg
     9001 ccgtaccggc ggtcgatgac gaagaacggc accccggtgg ctcccagctg cgaggcctcg
     9061 cgcggggcgg cccatgcggg ccgatacggc aggccggtag gctgacggct cccgtaccgc
     9121 cgacacggtg tcgggacacg cgacccgctc gaaaacgtcc cgcagtacgg cggccccgcc
     9181 cgagcagcag tcgcgggggc ccgagccacg acgccgtcag gcgacggaag tgcagcccag
     9241 gagtagagag tcgagcagct tggccgtggc cgcagggtca gtggtgtgat gcaccgttcg
     9301 gatgcccaac gcctcggcgg gcggcaggtt ctcggcgtgg tcgtccacga acacgcactc
     9361 cggaccggtc agcccaaggc tgtcgagcgc acgctgatag atgcgcgtgg acggcttgcg
     9421 gacgccctcc agctccgaca gcacgaccgc gtcgaagaag ccgtcccaca ttcccttgtc
     9481 ctcgtacggg ttgtacggct cggtgccgaa gctgttgctg agcatcgcga ccttgatgcc
     9541 ggccgagcga gcccgctgcg ccgcggcgac gatctgcggc tcgggacgca ggttggccag
     9601 ggcgcgccgc atcagatccg tcgggtcgat gccgaggatg ccgccgatca cacggttcca
     9661 gtcctcctgg gtggcttcgc cgacctcaag agctgagtag accgcgaccc cctcggggtt
     9721 ctcctccagg gcatggaagt aggcgccggg ctccagtcct tcggacttct cgaacgcctc
     9781 gccgttgagc ctcatgcggg tggtcaggac accgccgaag tcgaggatca ggccacggta
     9841 gggggtggtg gtcaatgcgg gctccttgcg gatgcgcgtg gtaccggaag cggtcccccg
     9901 gccgcgcgtg ccgccggtga ccgtgagtgc cctcccaaag ggagagaaga ccagtatcac
     9961 ccctgtccga cccgcgtggg catacgctct ttaccggcgc cctttccgag acgacggatg
    10021 gtcaacagat ggctattgac ggagagttgt tcagcatcgg tcagaggatc aagtggctca
    10081 gggagcggcg tgggatgtcg cagaagaccc ttggcgactt tatcgacagg tcagagaact
    10141 gggtctacaa gatcgagcac gaccggatgc cggttgatcg cgtgtcggtc ctcgtcgctc
    10201 tgtgtcaggc gcttcggtgc agcatggagg atttgaccag cggctacgtg tccagcatcg
    10261 ccaccggtga cgccgaacac gagcacgttc cgacgatccg ccaggctctg tctctgccct
    10321 cttcgctgct cccgctgcgg attgccggcg tcaccgcgga cggcttcgaa gagtcggtca
    10381 ccgacgcctg gaaggtgtac gagacgcagg cggaagcgcg ttatcaggac gtcggtgggc
    10441 gcctgccgaa cctcctgcgg caagggcacg cggcgctgcg ggacgcgaat tccgaggacg
    10501 aaccggccat tctccgccag ctcatcagcc tgtatggcct gcaccaaatt tggcttcggc
    10561 gcgtaggcga acccacgctc gcgaggatcg ccgccgaccg tggtctggcc ctcgcggaca
    10621 acgcgggcga ccctgcgctc ctcgctgcgg cagcctggaa cctctcctgc gtgctgacct
    10681 cagccggtga cgtggccgac agtctcgaac tggcccggca gactatcgcg cagtgcaagc
    10741 cggccgacga cgcctctcct gagcactggt cggcgtacgg ggcgctgcac ttgcagggcg
    10801 ccgtggccgc ggtccgcgcg accagcccgg tggcatggga tctgtaccga ggcgcccagc
    10861 aggccgcaaa gaaggttggt ggggatctca accactggca cacctgcttc ggccccacca
    10921 acgtggcgat gcacgaggtc cacctgatgg ctgaggaggg tgacgtcagc gaggctcttc
    10981 gcgtcgctga ctcggttcag gtcaacccgg agctgcccct ggaacgtcgg acgcgctacc
    11041 tgatcgaggt catgaacctc aacagggttc agcgcgacga ctacgcgacg gtgcacatcc
    11101 tcgggaagct caagaagcag tcgccggaag agatcgtgtt ctctccgctg gtcaggcagg
    11161 ctgtcgccga gctgttgaag cgggagaagc cgctgtggcg ggacgacctg cgcgaggtgg
    11221 cgaagcacgt cggtttcgcc gcctagtgat catctaaccc ctgagagtta ctaagccctg
    11281 attttttctc agggatcacc gctccacatg gccctacgtt aacgagctat gacgacgagt
    11341 cacgttcaca cggaagccgt cgcaacaccc ttaccggccg agaagcgcca cctgcgtctc
    11401 tcgactgagg ccaaggtgag ccacacccag gccgggcgct tcacggttcc cctcgacctg
    11461 tgcgaggggt ccgcggagcg cacgcccctc ccgctcatcc tgacggccga ggaagccgtt
    11521 gacatccacg cccagctcag cgccctcatc gccgagaagc agggcggtgg tgcagcgtga
    11581 ggacccccac ccgccgcacc agtggagaac tcgcgcgccg aagggccctg gccgacgcct
    11641 cggccgagcc gtttcccccc tccctgatct cccttcgcca ccccctgcct gcccagcgtc
    11701 gccgacgcag cggcctcagt gcatcactcg atgacgtgag ccccaaagca gacagggagc
    11761 agaggtgacg gcgacgatga cggcccctgt gctggcctct ccgcgcatgt tgccccgcac
    11821 tcacgacaca atggcggcct gcttcgccat cagtccccga ggcgaacatc aagccatccc
    11881 ggcacaggac gtgcggcgcg tctccgcgat gcgccgcctg gccagagcgc gcctgaggta
    11941 ctgccgtctc tccgcgctgg ccgatgacat cgcgctgatc gtctccgagc tggtcacgaa
    12001 cgccatcgcg cacagccacg gcaccgacat cacgatgacg ctcgtgctca accacgggct
    12061 cctgcgtctc gaagtgaggg acgagaccgc tcgtcgccct gagatccagc agccggccga
    12121 cggcgcggag cacggccgcg gcctgattct cgtccaggcc atcactgagc agtgcggcgg
    12181 caagtggggc accggcccgg acggcacgag cacctggtgc acgatcccgg ttcccgccga
    12241 gggagaccag tgaacgccac catgaccgcc ccgaactcta ggaactcatc gaactcgggg
    12301 ccgcccgcga cccccgcgtc gtggcggcgc tccgccagcg cccgaaccct cgcgcgccgt
    12361 ccaccacgac accgccggcc ctgggcgagc cgacgagaac ggagagcatc cgccgatagc
    12421 ctcccggccc accggcacgc tgctgccggc tctacccccg aacacgtacg accgaaggaa
    12481 cttcatgacg accaacacga ccgtcgagcc cgacgaggcg acccgtctgc ggaacaaggt
    12541 ggtggacgag ctgtgcgcgg acggcacgat gtcgtcccct gagatcgaag cggcgatgcg
    12601 caaagtggcc cgccacgagt tcgcccccga ggcgcctctg gagaaggcgt acgacacgta
    12661 tgccgctgtg atcaccaaga cggacgagca cggcgtgcag ctcagctcgg tctccgcgcc
    12721 gcagatccag gccctgatgt tggagcaggc ccgcgtgcgg cccgggatgc gggtgctgga
    12781 gatcggctcg ggcgggctga acgcggccta cctcgccgaa ctcgttggcg aggacggtga
    12841 agtcgtcacc gtggacatcg accccgtcgt caccgaccgc gctcgtcggc tcctggacga
    12901 gcacggctac ggcagggtcc acgtcgtcac cgccgacgca gccgagcccc tcccggacct
    12961 cggtgaggtc gatgtcgtca tggtgactgc cggggcctgg gacatccccc cggcctggac
    13021 ctcgcagctc aagcagggcg gccggctcgt ggtgccgctg cggatgcggg gcctgacccg
    13081 ctcggtcgcc ttcactcgcg tgtcgggcga gcacggcgac tacctggaga gcgagtcggc
    13141 gccgatctgc ggcttcgtac cgatgcaggg ctcgaccgcc caccgggaag aacttctgct
    13201 ggtcaacggc accccggaga tcggtctgcg cttcgatgac ggcctgccgg ccgacccaca
    13261 ccggctggac aacgccgtca agacactgcg ccacgagctg tggaccggcg tcaccatcgg
    13321 cctccaggaa ctcctcgaca cgctccagat gaccatggcg atcagcctgc cgggcttctg
    13381 cacgatggcc gtcgatgacg acctggacac gggcctggtc gccccggtga acaagcggtt
    13441 cgcactcgct gccgtcgagg acgacacctt cgcctacctc gtcacccgcc gcaccgagga
    13501 caacaagcac gtcgagtacg gcgtgcacgc cctcggcccc aacgcgaagc agctcgccga
    13561 cacgatcgcc ggcgtgctgc gcgactggga agccaaccgg cgcggcggcc ccagcccggt
    13621 catccgggtc tatccggcca gcacctccga cgatcagatc ccggctgacc gggtcatcga
    13681 caaggtgcac agccgggtct cgctctcctg gccctcggcg taacgccgag agccaggcag
    13741 tcccgcacca ccgaaatgga aggaagggca ccatcatgac gagcgccacc ctggccccgc
    13801 ccgccccgct ggcggacctg gacgacgacg acttcgcgcc cctggacgtg aaggtcgtca
    13861 tcgccgagca cccgtacggc aagctcatgt gctccaccgg cgacggctgc ggcagcacct
    13921 gcgcgaccaa ctcctccgcc tgcaactcct tcgtggagga cccggcctga tccaggtcac
    13981 ttcccgccgg ggggctgggc gcatcgctgc gcccggccct cgggctctcc ccctcccgcg
    14041 cgtcgcctga aggaagggac catggctccc cgagcagtcg ccaactacca gtggcagggc
    14101 gccgcgatgc tgcgcgccac caccagcccc ggaccggcag acgtcccccg caccctcaac
    14161 ctggacgacg tggccgctac ccgcgggtgg ctgaaccgcg tctggcagcg cgaagaagtc
    14221 cgcagcgcgc tggagttggc cacccccgtc ctgtctgctg ccgtcgaggc cgtgggccag
    14281 ggcaagcaga gcgatccccg ccacgttcgc cgtaccgcgt tatccgccgc ctcctacctc
    14341 ctgcggtggc agcaccgccc caccccgctc ggcttgttcg ccggcaccgc tccactgtcg
    14401 gtcgggccac gggcgagcgt gcgatggcgt gacaaacacc gagtggcgat ccggcccgac
    14461 gccgagtgga tcaccgacat catcctgcgc ctccagcgca gccccgagct gctgaagcgg
    14521 ttaccgctga tcgccaacaa cgccgcccgc acccgaggcg accggcttgt ggcgccaggc
    14581 ccgcccgccg acggctacgc ccgcctcctg gcccccgtcg aaatatccgt ccgtcacgcc
    14641 cggccggtgg ccgccgccat ggacgcggcc cgcaccccca tcacgtacct cgacctccac
    14701 acccgcctgc gcgacacctt cccgcaggcc accacagaga agatcggcgc cctcctcggc
    14761 agcctgatcg aacaacaact cctcatcacc agcctgtggg cccccatgac caccgtggac
    14821 gccttccagc acctgatgcg tgaactggag aagcaccagg cggacaccgt gccggatgtc
    14881 cgggacctgg tccatacact gaacacagtc tgcgaggacg tttccgccca tcagcctgtg
    14941 ctctttggca ccggagtggg cgccattgca gcgcgaatgc gcgacctctc cccggtcacc
    15001 ccgacgcctc tgctcatcga caccgccctc gacggagagg tgcagctccc gcaggccgtg
    15061 gtcgcggaag tacaagtggc cgtcgcgggc ctgtaccgga ccacgccgca gccctacggc
    15121 taccagcact ggcgcgacta ccaccgccgc ttccgagccc ggtacggagt cggcgccctg
    15181 gtgcccgtga tggacctggt ggctgacagc ggccttggac tgcccgccgg gtacgtcggg
    15241 tccgagcgcg gccccgcgcc gaagctgctc accgaccgcg acgaggtact gctcgccctg
    15301 gtgcagcagg ttctcatgga cggccacgat gaactccggc tcaccgacgc gacgatcgac
    15361 gccctggaga aggccgccgg aagtgacgag cggctgttcg tgccccgggt ggaagtcgcc
    15421 ttcgaggtcc acgcgcccag caccgcggcg ctcgcccgcg gcgccttcga cgtactgctg
    15481 acctcagtcc cgcgccccgg cagcagcatg gccggccggt tcgcccacgt gctgccgccc
    15541 tcgcagcagg acgcgctcgc cgccacgtac cgcggcgccc cggacgcact tcccactcag
    15601 ctcgtcttcc ctccgcgccg ccgccgcaac gagaacgtca cccgcacacc tcggctgctg
    15661 ccccacgtca tcgaactgtc cggccaccag agggccgacg agacgacgat cccgctcgcg
    15721 gacatcgccg tcaccgccga cgcccgcacc ttccatctcg tgcagctctc caccggcagc
    15781 cacatcgacg tgcgagtcct gcacgccctc gaagccggca cccagacccc gccgctggcc
    15841 cgcttcctcg cagaggtggc caccgcgcgg tacgccgcct acaagccgtt cgacttcggc
    15901 gccgccgccc ggctgccctt cctgcccagg gtgcgctact gccgcaccat cctcacccag
    15961 gcccgatggc tgctgagtgc cgaagacctg cccggccgga cagccccggc aacgcagtgg
    16021 gatcaagcct tcgacgcctg gcgaggccgc ctccgcgtgc cgaaccacgt cgccatgatc
    16081 gagtacgacc agcgacttcc actggacctg acgcatccgg tccaccgccg tgtgctgcgc
    16141 gccgccctcg acaacgcccg gcgtctggat ctgcgcgaag tccccgacag cgacgcccac
    16201 ggctggatcg gacgggcgca cgaggtatgg ctctccctcg gtcttcctca gcccgaggac
    16261 gccaacgcgc cccggccact ccccgtcaca ccggccgcaa ccgagcgaca tcttcccggc
    16321 gccggcgaca tcctccacgc tcagctccac gcccacccgc gccgctacga cgagatcctg
    16381 agccgacacc tgcccaacct tcttgccgcg ttcggcgaca ccccgccgat ctggtggttc
    16441 acccggcacc gggagatggc ccgcccggac gccgaccagc acctcgacct caccctgcac
    16501 ctgccgcagg gcgcgtacgg cacctcggcc gaacacgccc acacctgggc ggacactctt
    16561 cacgccctcg gcctggcgtc cgggctcgtc ctggccgcct accaaccgca gaccgggcgc
    16621 ttcggccacg cggcggccat ggacgccgcg caccaggtgt tcgcagcgga ctccgccgcc
    16681 gccctcgcgc agatccagct caccgagcgc accgacgtct tcgccccgca ggccctcgcc
    16741 gcggccagcg ccctgagcct cgtcactcac ctcgcaccga gcgccgccga ggccgaagag
    16801 tggctggtac gcaaccttcc ccagggcaag gggcggctgg accgggcact gcggaaccag
    16861 gtgctcgaac tagccgcgcc tgaacgggca tccgctctcg ccgcccttcc cggaggttcc
    16921 caggtcgccg aagcgtggcg ggcccgcgcc gccgccctgg acgtctaccg gaacgccctg
    16981 gcccgggagc gtgacccgct cgccgtcgcc cgatccctac tgcaccagca ccacgtccgg
    17041 gctctgggcg tcagcccgag caccgaggcg accacgctgc ggctcgtacg cagcgcggcc
    17101 cttcagcacc ggatgacgag ccgatgaccg cgccgaccgc caccgccggg acgctcctgg
    17161 agcggtacgc cagccatctg gcagacccct ctccccctcc accaaaccaa ccctgggcgg
    17221 tgcagtccct cgccgacggc gcggccggga tcagtctgct acacatcgag ttggccggcc
    17281 ggtacggcgg ctcctggcgc cccgcccacc ggtgggtcac cgccgctgct gccgggcaca
    17341 tcagcgcagc cgacaccacg ggcctgttcc tcggtgcccc ggctgtcggc ttcctcctca
    17401 ccgccgtccc gccgcccttt cagcacctgt acgacgcggc gcgcaggacc ctccaccagc
    17461 acatcaccgc gcttgcccac cgccgcgtgg atgcagcgct tgctcgaatc agcaaccgcg
    17521 atctgcccgc cttcgcggag tacgacctct tctacggcct caccggcatc gggtcctacc
    17581 tcctccgtac cgaccctcag ggagctgcgc tggaacgagt cctgcgatat ctcgtagccc
    17641 tgacccgtcc gctcgccccc gggggccgcg gcctgcccgg ctggtgggtt cgtcatgacc
    17701 cagcccgcgg tgaatcgccc ctcttcccgg gtggtcacgg caacttcggg gctgcgcacg
    17761 gcatcaccgg tccgcttctc ctcctggccc aagcgctacg ccgcggcatc accgtcagtg
    17821 gccaccaaga ggccatgttg actatctgtg aatacctcga cgcgtggtgc cagtacgggc
    17881 catccggccc gtggtggccc gagcacgtct cttgccgcga cctcgaacgc ggatgccctc
    17941 accacggcgc ccccgcacgg ccgagctggt gctacggcac ggcaggcatc gcgcgggccg
    18001 ggcaactcgc cgggatcgcc ctgcgcgcac ccgacctcca ggcgttctac gagaacgccc
    18061 tgtaccaggc cctgaccgac cccgtacagc tcgcccacgt caccgacacc ggcctgtgcc
    18121 acgggtgggc aggcatctac caaaccgcgg cccgtgccgc cgccgatgcc cgtgacctcc
    18181 gtctccaggc tctcccgcag cgcctcggcg acaccctcgc cgcgcaggcc gcacccggcg
    18241 tcacccccgt gaaggggctg ctcaacggcg acgccggcac cgcgctcgcc ctcaccaccc
    18301 tcgcctcgca gcaggcaccg accaccggat gggacgcatg tctcttgatc aactgatcca
    18361 ggccgatccg agcccgatcc agcgcgcggt cctcgccgtc ctcaccggcc tgccgatcgc
    18421 cgacgccgca caccagcacc ggatggaccc cgtgatcctc tccgacgccg tagcggtcta
    18481 cgaccaggcc ggccgggagg ccctggcccg ccacgcctcc accaccgact ggtggcaggt
    18541 ctacctccac ttcaccgact gggccaacgc cgacaccacc ttcaccacgt cagtcctgcc
    18601 catcctgtgg gaggcggagg ccgcaggcac catcgacggc tggtggtaca ccagaaagca
    18661 cccctgctgg cgcctgcgcc ttcacctgcg gcccaagacc gggaccaagc tgcccgtcgg
    18721 tgacggcttc gaccgcctcg tcgccgacgg gcacctgcaa cgctggtggc ccggcatcta
    18781 cgagccggag acgccagtgt tcgggggtgc ggccggcatg acggccgcac acgccctgtt
    18841 cgtcaccgac agccgggaag cacagcagtt gcggcaacgc gacgacctgg ccgtggggcc
    18901 gcgggaactg tccgtcctcc tgtgcacgat catgatgcgc gccgccggac tggagtggta
    18961 cgagcagggg gatgtctggc accgcgtcat cacgagcgaa caccgctcag ccgtcggcga
    19021 tgttccagcg gaccgactca acgcccgcgc ccaggagatc cggcccctgc tcttcgccga
    19081 cagcgacgcc ctgctgcgtt ccggcgggcc gctggagccc gtcgccgaat gggccgccgc
    19141 attccaccgc acgggccagg cactcggcca tgctgtccag tccgggacgc tcgaccgcgg
    19201 gttgagggag gtgctcagct accacgtgct cttccactgg aaccggctcg gtctgtcgat
    19261 gcggggccag agcgtgttgg cctgggcagc cagggcggcg atcctgcaca acgaaagcgg
    19321 gacatagatc ggctgcggtt gtaacgccta gcgcggtgac ttcgtctaca aggcgggtca
    19381 ggcgttgacg ctcggccacg atttgctgaa tcgccgccgg gaggaacacg tccgactgct
    19441 cgccctgcga caacaaggtc cccggcagcc actgatacgg cgctggagtg tctgccactg
    19501 ctctcgtttc cgagtgcggg ggcagtgccg cgtctcccac cgcccataca gaggaagccc
    19561 gttgcctgca cgacatgaca tcgatgccga acgtgaactc tgggacacct tcgccgagag
    19621 cacaaaagac aaggtcttcg aatctgagtc cgtcttctgt tggacgcagt acgccggaca
    19681 cgggccgggt cccgagctcc tgggcaatcc gacgacagcg cttgagatcg gatgcggaac
    19741 aggacgagcg ctcgcctacc tcacgcaaca gggtgtcaag acgaccgggg ttgacctctc
    19801 ccccgtaatg gtcaagcaca cttccgagcg ctggggaccg ttgggcgcgc agttcatttg
    19861 cgccgaagta ctggaccatc tgagcaacag cacagagcgc tacgacaccg tttactcgat
    19921 cttcggggcg gcctggttca ccgatccggc gaagctgttc ccgttgattg ccgagcggtt
    19981 gaaccccggc ggagtcctgg cgttctcaca ccccccggca attcccggag catacggccc
    20041 acaaggcatg tacaagggag ggttcgcggg taaggcgatg ttcacctatc gctacagcta
    20101 cacgccccgc aagtgggcga acctactgtt gcgttccggc ttcaaagatg ccgacgttca
    20161 gatcctcgac gcgccgaagc ccggtcatat cggaacactg atcgtccgtg ccgtggctga
    20221 ctgaggctgc cccaactccc cgcgcatgga ggctggtcag cgccttgcgg cagccagcgg
    20281 ttccgtgagt tcaccctcag tcgacgtcag accgggtgcg acgcgtatga gctgacttcc
    20341 tcgttgtgga ggtgtcccgg tgcaccctcg gcgacggcgg gccattccgt gggtaccgtc
    20401 cccgcatgac ctcgtcacag ggatttctcg ggttctggga gacggccggg tccgccaaga
    20461 ccttcaccca cccgctcgac ccggcgctgc tggacgcgta tgtgccgcgg agcgcgcggg
    20521 tgctggacta cggatgcggc tacgggcggc tgaccgccga gctggccggg tccgggtacc
    20581 gcgcggtgcg cggggtggat gtctcggcgg cgctgatcgc gcgggggaag cgggagcatc
    20641 cggagctgga gttgctgcac tgtcccggtt tcccgctgcc gttcggggac ggtgctttcg
    20701 atgcggcgct gctgttcgcg gtgctgacct gtgtgccccg ggacgcggac cagacggcga
    20761 tcgtcgggga gctggggcgg ctggtgcggc cgggtggggt gctgtatctg agcgatgtgc
    20821 cgttgcaggg ggacgcgctc aaccgggagc ggtatgcgcg tttctcggcg cggtacggga
    20881 cgtacggggt gttcgagacg cccgacggcg gggtgttccg gcaccatccg ccggagcggc
    20941 tgcgggggct ggtgcgggag gcgggcttct cggtggtgaa ggagcgggag gggtcggtgg
    21001 ccacgctgga cgggcagacg gccgatcggc ttcagctcat cgcccggcgg gatccggtgc
    21061 cgccggagcc ggtgccgccg ggggtgtcgc caggtccagc cacagggtga ggtgggtggc
    21121 gtccggggcg gggcggcggt ccgggtcggg gcgccagccg agccgggtgt agaaggcgcg
    21181 ggcgcggtgg ttgtgccaga gcacgtcgag gacggcccgg gagaaacccg ccgtgcgcca
    21241 ggcccgcaga caggcaccgt gcagggcgcg gccgacgccg gtgccccagt ggccggggtc
    21301 gacatggagc tggtggaggg tgacggccgg ccggtggtgg tcggcgcggt ggcggtagga
    21361 ggccgcaccg accacggtgc cgtgccgggc ggcgcagagc gcgggggtgt cgccccggtc
    21421 caggtcacgt aaccaggcgt cgtgccggcg ggcccgttcg gcgacgacgt cgaagggcgc
    21481 gtccgggaac cgggcgcggt ggtaggcggc acgggccccg gtgtgcaggg cggcgatcgc
    21541 gggcaggtcg gcggcggtgg cggcgcggac ctggagggcc gcgtcggggg cggggcgcac
    21601 ggtcgctaga cgccctcggc gcggccgtcg acccggcgcg gcagaccgag cgggttgtcc
    21661 tcgtgcagct cgggcggcag cagcgcggga ggggtgtcct ggtaggcgac cgggcgcagc
    21721 cagcgttcca cggcgctgcc gccgacggag gtggacgtgg aggtggtggc cgggtagggg
    21781 ccgccgtggt gctgggcggg ggcgaccgcg acgccggtcg gccagccgtt gacgaccacc
    21841 cggccggcga gcggggtgac ctcggccagc agccgggcgc cgcggcccgc ggcatcggtg
    21901 ccggcgctct ccgcgtcgcc gagctgaaga gtcgcggaga ggttgccggg gagccgggcg
    21961 agtacggcgc cgatctcggc ctcgtcggcg tagcgggcga cgacggtgac cgggccgaag
    22021 cactcctcca ggaggaggtc gtgcggccct tcggcggcca ggtgggcggc ggggacggcg
    22081 aggaaaccgg cgctgacggt gtgctcgctg cccgcgccgg gggtgaccgg cgcgtggaca
    22141 ccggggagcg ctgcgcgggt gcggaccccg tcgaggaacg cctcgcgcat ccggtggtcg
    22201 agcagcaccc cggcctcggt gtcgctgacc gccgcggtca gcgccgtcag cagccggtcg
    22261 ccggtctcgc cgccgggcgc caggaccagg cccggcttga cgcagaactg gccgacgccg
    22321 agggtcatcg acccggccag cccggccccg atctgctcgg cgcgctcggc ggccgcggcc
    22381 tcggtgatca cgacggggtt gaggctgccc agctcgccgt ggaaggggat cggatgcggg
    22441 cgggacgcgg ccgcgtcgta cagggcacgg ccaccgcgca ccgaaccggt gaagccggcc
    22501 gcgctgatca gcgggtggcg caccaggtcg ataccggcct ggaagccgtg caccagattg
    22561 accacgccct ccggcaggcc gacctccctg gcggcgcggt gcagcagcgc ggcacacagc
    22621 tcggaggtcg ccggatggtc cgggtgtgcc ttgacgacga ccgggcagcc ggccgcgagg
    22681 gcgctggcgg tgtccccgcc cggtaccgag aaggcgagcg ggaagttgct ggcggcgtag
    22741 accgcgacgg ggcccagcgg gatcttgtag cggcgcaggt cgggccgggg cggggtgagt
    22801 ccggggtcgg cgtggtcgat cagtacgtcg aggaacgcgc cgtcctcgac caggtccgcg
    22861 aaggcccgca actggtaggt ggtacgggcg agttcgccgg tgagccggcc cgggccgagc
    22921 gccgtctcgg cgtcggcggc ctcgatgacc gcctcacccg cctcgtccag cagatcggcg
    22981 gagcggcgca acagagcggc gcgtacggtg cggtcggcca gcgcgccacg ggcggcgtgt
    23041 gcggtgcgga ccgcggtgtc cacctcgtcg gcggtggctt ccaccgcgac ctgttcccgc
    23101 tgcttcccgg ttcgggggtc gacactccag actggtgctg ctgctgtcgc tgccaccgtg
    23161 cattcctccc gggcgatgct gccgagtcgt tccacgcctt gccgcacacc tgatcacgtt
    23221 cgatatcgtg aacgccgtcc cagatgatga acgactggga ctctatggcg gtccgaacag
    23281 aggggtcaag ggcgatgtca gctgctgaaa ccggtggatc gcaggtcaaa tccgcggtgc
    23341 ggacggtgga gttgctcgag tacttcgcgg gccgtcccgg tatgcacagt ctggcctcgg
    23401 tccaggaagc ggtcggctac ccgaagtcca gcctctacat gctgctgcgc accctcgccg
    23461 acctgggctg ggtcgagacc gacgcgaccg gcacccgcta cggcatcggg gtgcgcgccc
    23521 tgctcgtcgg cacctcgtac atcgacggcg acgaggtggt ggccgcggcc cggccgacgc
    23581 tggaccggct ctccgacgac accaccgaga ccatccacct cgcccggctc gacggcacca
    23641 acgtcgtctg tctcgcgacc cggcagtcgc agcactctct gcgccccttc acccgcgtcg
    23701 gacggcggct gcccgcgcac tccacctcgc tgggcaaggc actgctcgcc acgtacaccg
    23761 acgagcaggt ccgggcgatg ctgccgccgg ccctcgcccc gctgaccgag cacaccctca
    23821 ccgaccgcga gcagctgatc gaggagctgc acgcggtacg tgaacagggc tatgcggtcg
    23881 accgcgagga gagcaccctg ggcctgcgct gcttcggcgt cgcgatcccc taccgcaccc
    23941 cggcgcggga cgcgatcagc tgctcggtgc cggtggcccg gctggccccg gggcgcgagc
    24001 agatgatcaa ggaagcgctg ttcgacgccc gcgaccggct gacgctggcg acccggcggt
    24061 tgtgaggcgg agggccggtt gatatcggcg acggccggtt gagtgctcct cccccgtgcg
    24121 gcggaggagg atcgtcagcg cgggcgaggc gctgcggagc ggcggccggg aggctgggcg
    24181 ccatgagcaa ccggagaggc cacgccgcgc gggccccgta cgcggccgcc ctgccgcccg
    24241 tcatacgccc ggcgggtcgt gccgcccggc ccgtggggcg gctggctccg ccgacagcca
    24301 cgccgccccc gccggcgagg agctccactt acgctgtgcg gatgagcgtc gggacgagcg
    24361 tggcgggggc cggggcccgt ttcttcgccg tacgcgaggg cgcccggtgc tgctgatggg
    24421 tcggcgctgg gtccatctgg tgctcggcgg cgcgctgttg atgccgttct tcctgctgac
    24481 ctcggtcgtc gtgccgctgt tcgcggacgg cgccaacccg ttcctcgacg tgggctggca
    24541 gttcgtcgcg ttcggcggtg cgctgccgct tgccgccctg gccgcgctgc tcttcccgct
    24601 gctgcggccg ctggaggtgg ccgccgtacg gtcgttgtgc ggggtgcccg cggagcggct
    24661 ggccgagggg ccggcggtct cctgggcggc ccggcggcgt acggcgctgt ggttcgtggc
    24721 gcatctgctg gccggcggga tcgtcagcgg gatgacactg tccgcgccgc cggccgcggt
    24781 ggtgctgttg ttgctgccgt tcgccgaccc cctgcggcac accgcgctgc cggacacctt
    24841 ccacggcgtg ctgggcccgc tcgcggggct ggcgctgctg gccctggtgg tgggcacggc
    24901 ctggggtgcg ggggcgctgc tgggccgcgc cgcccccgtg ctgctgggtc ccacaccggc
    24961 cgaccggctg gcggccgccg agcgccgggc cgccgaactg gcgtcccgca accggctggc
    25021 acgcgacctg cacgacgcgg tcggacacgc gctgagcgcg gtcaccctcc aggcgggcgc
    25081 ggcccgccgg gtcctcgaca cggacccgga gttcgcccgc cgggcgctgg ccgccatcga
    25141 ggagaccacc cgtgacgcgg tcgccgaact ggacaccgtc ctcgggctgt tgcgggagga
    25201 ggacagcagc gatccggccg cgcccgcgcc caccctgaac ggtctggagg cgctgctcgg
    25261 ccgcacccgg gcggcgggcg taccggtcga ggcgacggtc gagggaccgt gcgcggggct
    25321 ggcgccggtg atctcccggg aggcctaccg gatcgtgcaa gagggcctca gcaacgcact
    25381 gcggcacgcc ggtccggtac cggtccggct gcatctcggc gtccgggagg gcgagttgct
    25441 gatacgggtg gagaatccgg tggcggggac gggggccggt gcggcggggg cccgggggcc
    25501 cggccgggtg ggggacgcgg gctgcggggg atcaccgagc gcgcacggct gctgggcggt
    25561 gcggcgtcgg cggcggaacg ggacggcgta tggcggctca cggcccggct atcactgacg
    25621 ggggcgggaa cggggacggt cacgggggca gaggcggggc cgggcacggg gacagaggaa
    25681 tggtgagcgg ggcgggcggc ggatgacgga cgaccgacgg ccgggaacgg cgagcggggc
    25741 ggcggatgga acacggccgg cggccgggaa cggggacgag cggggcatga ccacgacgca
    25801 ggacgacgac cagcggggcc aacacccgga cgccccccgc cccctccgga tcatgctcgc
    25861 cgacgacgaa cagatggtgc gctcggcgct gcgcgcgatc ctgggcgccg agagcgatat
    25921 ggaggtcgtc ggcgaggcgg cgaccggcgc cgaggcggtg ccgctgatcc gtgaactgcg
    25981 cccggacatc gtgctgatgg acgtccggat gccggagatc gacgggatcc gggcgaccga
    26041 gcaggtgctc gccgggatgg accggccgcc gcgcatcatc gtggtgacca ccttcgagaa
    26101 cgacgcctac gtctatgacg cgctccgggc cggtgccagc ggattcctgc tcaaacggtc
    26161 cggcgcggag gacctggtgc aggccgtacg gctggtggcg cgcagcgact cgctgctgtt
    26221 cccggccgcc gtacgccaac tggccgcccg gcacgccgca cagcgcgccg cggacgacgc
    26281 ggtgcggaca ctgcgggccc ggctgtcgga gcgggagcgg gccgtactgc gcctgatgac
    26341 ggccggaatg acgaacgccg agatcgccga ccggctcggg gtgggcccgg ccacggtcaa
    26401 gacacatgtg gcgggcgtac tcgccaaact cggcgtacgg gaccgcaccc aggcggtgat
    26461 cgccgcgtac gagtgcgggt tcgtccggcc ggggtgaggg ccgggggcat cgggtcggcg
    26521 tgaggggggc gccccctcac ccaccctccc ccaccaaccc caacccgcgc tcaaccaacc
    26581 tcgccagctc cttcacatgg gcagaagacg gttcgctgag cggtggccgg accgggccga
    26641 cgtcgcggcc gcgcaggcgg acgcctgcct tgacgagcga gacggcgtag ccgtggccct
    26701 ggttgcggag ttcggccagg ggccggtaga agccgtcgag cagccgctgc acggtggtgt
    26761 cgtcgccggt gtgcagcgcg cggtggaagg ccagggcgat ctcgggggcg aaggcgaaga
    26821 cggcggagga gtaggggtgg acgcccaggg cccggtaggc gggggcggtg agttcggcgg
    26881 tgggcaggcc gttgaagtag cggaagttct cttcgggggc ctcggtgcgg acggtgctga
    26941 tgatgcgctg gagcagatcg aggtcgccca ccccgtcctt gaggccgatg atgccggggg
    27001 tcctggccag ggcggcgacg gtggcggggg cgaagacggc gttgtcgcgc tggtagacga
    27061 tgaccgggag cggggtggcg gcggcgagtt cggtgtagtg cgtcagcagg ccctgctggc
    27121 cggggatgac gagatagggc ggcagggcga gcagcccgtc ggcgcccgcg gcgtgcgcga
    27181 gttcggcgca ctgcacggcg agcgcggtgc cgtagcccgt gccggcgagc accgggaccc
    27241 ggcccgcggc ctcctcgacc gcggccgcga cgcagtccgc gaactccccg ggggtgagcg
    27301 cgtggaactc gccggtgccg cagcaggcga agacggcggc cgcgcccgcg tcgatgccgt
    27361 cgcgtacatg ggcgcggaag gcggcggggt ccggggcgcg gtccggtccg tacgcggtca
    27421 cggggaagaa cagggggccg tcgaggcggt cggtgagccg gcgctgctgc ctccctacgg
    27481 tggcgggggg aggggctgag gtcacgggcg ctccctggca tacctgtgca cgtttatgat
    27541 cgacgtccat atttctgaac ggcgccacgc taggacagcc gcaccgggcc ggtcaaggtg
    27601 ccacaactgc cgtgccacaa gccgtttcac accacccgtc aagcgtcttg acctgccgag
    27661 atccggcttt ctacggtcgg tgtccagcca tctgaatgac gtccgcaccc gcggccctgc
    27721 cgcccggccg gaggagtcgc cgcccatgac cgcaccccgc accgtcctgc tcaccggcgc
    27781 cgccggcggc gtcggcaccc tgatgcgcga gctgctgccg ccgtacggct accggctgcg
    27841 cctcttcgac cggcggacca tcgagaccac ggacggcgaa ccggacgcga tcaccgccga
    27901 gttggccgat acggtggcgc tgcgcgcggc ggtggacggg gtcgacgcga tcgtgcacct
    27961 cgccggtatc tcgctggaag cccccttcga gcagatcctg cgcgccaaca tcgagggcac
    28021 ctaccgtctt tacgaggcgg cccgcgcggc cggtgtccgc cgggtcgtct tcgcgtcctc
    28081 caaccacgcc gtcggcttca ccccgcgccc cgcggacggc tccggcgcca tccccgtcgg
    28141 cacaccccgc cgccccgaca cctactacgg cctgtccaag ggcttcggcg aggacctcgc
    28201 ctcgctctac tgggacctgc acggcatcga gaccgtctcg gtccggatcg gctcctgctg
    28261 cccggagccg acctcggtac ggatgctgtc gatctggctg agcccggccg actgcgcacg
    28321 gctgctggac gccgcgctca ccgcgcccgg cgtgggccac accgtcgtct acggctcctc
    28381 cgccaacacc cgtctgtggt gggacctgtc gaccgcccgc gcactggggt acaccccgcg
    28441 ggacgactcc gagccgtacg cggcggagct gatcgccgcc cagggcgcac tggaccccgg
    28501 caaccccgcc cacgcccatc tcggcggctc cttctgcacc gacccgcccc ggtggccgca
    28561 ctgaccggcg cgccccacgg ccgtaccggg caccccacgg gccacgccac ggaacccgtg
    28621 ccgcccacca ggcgtcctcg tctacgtacc gaatctccgc gcaggaacga ggaacgcatc
    28681 atgggcatcg tcagctggct cgtactcggg ctgatcgcgg gcgtcatcgc caaggttctg
    28741 ctgccgggac gggacccggg cggggtcatc ggcacgaccc tgatcggcat cgtggggtcc
    28801 ttcatcggcg gctggctctc cacgaaaatc ctgcaccgcc cgattccgaa ggacttcggc
    28861 gagccgtcga tgtgggtctc ctcgatcgcc ggggccctgg tcctgctgat cgcctaccgg
    28921 ctgctcttcg gcaactcccg cgaacgccgg tgaacgggcc gggccgccat ccggccgcag
    28981 gtaatggaac cgcaaaggcg cgccgatcgt tgagcccggc atgaccgcta tgactcctgg
    29041 ctcgaacctc ccgctcagtg ccgtgcgggt ggcggtggac gtcaccgccc ccgtgcggct
    29101 ggacgtctcg ggcctgctgc tggccgccga cggcaaagtg cgctccgacg acgacttcgt
    29161 gttctacaac cagcccgccg ggccgggcgt gacgcactcc gcggcggccg gcggcggcga
    29221 caccatcacg gtggacaccg ccgcggtgcc cgacggcatc gagaagatcg tggtcaccgc
    29281 gagcctggac acccccggcg cgaccttcgc cggcaccgaa ccgaccg
//
