LOCUS       NZ_CP050976            23423 bp    DNA     linear   CON 06-JUN-2024
DEFINITION  Streptomyces sp. RPA4-5 chromosome.
ACCESSION   NZ_CP050976
VERSION     NZ_CP050976.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. RPA4-5
  ORGANISM  Streptomyces sp. RPA4-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9051652)
  AUTHORS   Nicault,M., Bontemps,C., Tidjani,R., Gelhaye,E. and Leblond,P.
  TITLE     Mining the biosynthetic potential for specialized metabolism of a
            Streptomyces soil community
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9051652)
  AUTHORS   Leblond,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2020) Dynamique des Genomes et Adaptation
            microbienne UMR 1128, Universite de Lorraine - Institut National de
            la Recherche Agronomique, Faculte des Sciences et Technologies
            Boulevard des Aiguillettes BP 70239, Vandoeuvre-les-Nancy F-54506,
            France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 72x/76x
            Sequencing Technology :: Oxford Nanopore GridION/Illumina Nextseq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012273495.1-RS_2024_06_06
            Annotation Date                   :: 06/06/2024 02:35:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,979
            CDSs (total)                      :: 7,887
            Genes (coding)                    :: 7,432
            CDSs (with protein)               :: 7,432
            Genes (RNA)                       :: 92
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 455
            CDSs (without protein)            :: 455
            Pseudo Genes (ambiguous residues) :: 0 of 455
            Pseudo Genes (frameshifted)       :: 276 of 455
            Pseudo Genes (incomplete)         :: 232 of 455
            Pseudo Genes (internal stop)      :: 23 of 455
            Pseudo Genes (multiple problems)  :: 71 of 455
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:36:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 674220
            Orig. end                         :: 697643
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP050976.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23423
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23423
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23423
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13423]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13423
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(464..1723)
                     /locus_tag="HEP86_RS03185"
                     /old_locus_tag="HEP86_03185"
     CDS             complement(464..1723)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556023.1"
                     /locus_tag="HEP86_RS03185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03185"
                     /product="hydroxymethylcytosylglucuronate/cytosylglucurona
                     te synthase"
                     /protein_id="WP_248000984.1"
                     /transl_table=11
                     /translation="MADVLAAVNSSIGLRNSGLTIAVAGAEFGWGSTGKLCAVIAELRR
                     SAPVPLRFVGLASRLSRTLLAAHGVDQWYDVATDDREAVAEVARRENVSAGLVVLEGPA
                     ASSLEAAGVPTVFVDSLPFLWTRSDLPSLPLDVSVYCAQRCIELEPHSRDLLAAVRNLQ
                     WVEAVVLENSGTQGAHPGNASPAAGPFQRALVSFGGLRSPTLTDWTSYPRVVLPAALNA
                     LERAGFSEVHVAGNLPPEFPREPVRASHPVDGASMKVTYGALPHAEFLRHVSDADVLLT
                     SPGLTTLLEAGARSTPVVCLPPQNLSQIFNGRFHSRAVAADTRVRWPDDVFCEEAVLRD
                     RTSSEEAVLRQIYGGISAAAKSPDRAETAVGAGVLAALERARAGADWSGLARGVGSGGA
                     RQVAGHVLALARPTSGAVSG"
     misc_feature    1708..1722
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(1846..1861)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            complement(1883..2557)
                     /locus_tag="HEP86_RS03190"
                     /old_locus_tag="HEP86_03190"
     CDS             complement(1883..2557)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433010.1"
                     /locus_tag="HEP86_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03190"
                     /product="response regulator transcription factor"
                     /protein_id="WP_248000985.1"
                     /transl_table=11
                     /translation="MATSEKVLESLELAGYQAAGASTRAAALVLLAAQRFDLLIIDTLM
                     PDAHDLAGYQRLADGSAPVLFLTDPTSLDGLCPWLSLGVADYVLKPLRVPEILARVQVL
                     LHDRGAARPERTPRQAADLTLGDLILNDATCQVWRGPRELSLSPTEYRLLRCLLLHPGQ
                     VLSKEQISRNVWGEDRARTENTIESLISRLRRKVDREAPPLIHTRKGFGYWLGAGEGVG
                     GP"
     gene            2722..2928
                     /locus_tag="HEP86_RS03195"
                     /old_locus_tag="HEP86_03195"
     CDS             2722..2928
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_03195"
                     /product="hypothetical protein"
                     /protein_id="WP_168477098.1"
                     /transl_table=11
                     /translation="MFLDAPVASQGECIAELGDSFGEFHGDHWVPCAGGAHHGDVVPVR
                     DDGVGVVDSECGQGRRELVGVLR"
     gene            complement(3201..3350)
                     /locus_tag="HEP86_RS03200"
                     /old_locus_tag="HEP86_03200"
     CDS             complement(3201..3350)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS03200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_03200"
                     /product="hypothetical protein"
                     /protein_id="WP_168477100.1"
                     /transl_table=11
                     /translation="MTLRAVADCLTVQHNSMRWHLGNKQGLLARLAEPINGSGAGHAPA
                     DRAL"
     gene            complement(3369..4370)
                     /locus_tag="HEP86_RS03205"
                     /old_locus_tag="HEP86_03205"
     CDS             complement(3369..4370)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_03205"
                     /product="hypothetical protein"
                     /protein_id="WP_168477102.1"
                     /transl_table=11
                     /translation="MTDLTSRWKARARLALAGQSVDSATADMVLDEVDLHCAQSGETPE
                     DAFGAPEKYAAAVARDRIPPEERTGRNWDGLTRADQVSAALAQTGVAVLVAGVCMWVGD
                     GTMLTVTPAGVAGSALLGVAIPSACLTATLASSRARGAVRWGVGAVAALLLSAGAFTYL
                     PTASYGRLPVPALCALGVLLLWSAARYKPGPDHKELTSESQLLPENWLVELPRLLEERH
                     GLSRARAAELTREAAHHLTATGCSPQEEFGPVELYALQVAEGQSVPRTRWWMRPDAQAA
                     ALAVLLVGYLVTNLASAGPAWQTVLAAVALATELALLTVSLLRKRPAVSTAR"
     gene            complement(4367..4708)
                     /locus_tag="HEP86_RS03210"
                     /old_locus_tag="HEP86_03210"
     CDS             complement(4367..4708)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015513.4"
                     /locus_tag="HEP86_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03210"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_211117276.1"
                     /transl_table=11
                     /translation="MKEPSSGWLRGVLPLALAAVLAQGDQHGYALVQQLAAHGFGTIRG
                     GALYPVLGRMETEGLVEARWEPGEGGPGRKVYRLSDAGRARLLEETATWQRFSDSMDRL
                     LEQVTKEEW"
     gene            complement(4982..5944)
                     /locus_tag="HEP86_RS03215"
                     /old_locus_tag="HEP86_03215"
     CDS             complement(4982..5944)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971303.1"
                     /locus_tag="HEP86_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03215"
                     /product="phosphotransferase"
                     /protein_id="WP_168477113.1"
                     /sec_met_domain="APH (E-value: 6.2e-22, bitscore: 77.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNHDEAAAVRPLTLAWVSRHLEAGERIVRTEALHGGITAEMRRL
                     TIGTRDGGTRDLVLRSFVDPFSVGHAEDWLNREAGALALLTGTGVPAPGLVAVDPTAAH
                     GEYPSLLMTHLAGRAVLDDEGLETRVPLLARQLVAIHALRPAERPREYVALTTADTVVV
                     PKGADAAVWAAAIDVIRRPAPPYEGRFLHRDFQPGNVLFDVPPARPAGARITGVIDWAA
                     TSWGPADLDVAHCSTNLALLHGQAWGLRFAAAYEEAGGVLAEAASERLYWQVRDGLACS
                     EEVQQVARPWREAGRTELTTRAVGERLDAYVTALMDALG"
     gene            6092..7000
                     /locus_tag="HEP86_RS03220"
                     /old_locus_tag="HEP86_03220"
     CDS             6092..7000
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182363.1"
                     /locus_tag="HEP86_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03220"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_168477115.1"
                     /sec_met_domain="APH (E-value: 1.9e-36, bitscore: 125.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSESEITADLVHDLLREQHPDLAGLAIREVAGGWDNQQWRLGN
                     ELAVRMPRSDRAPDLQRKECRWLPVLAPRLPLPVPNPVRIGAPSARFPKPWTIMTWVPG
                     EPLDVTSISRTDHAADTLADFLTALHVEAPADAPIGADRGAHPKKYTEGFDYFLQAVAL
                     DGVADEVRAVWDDAVAAPEWEGPPVWVHGDLHPANVVVSDGTLSGVVDFGDMCTGDPAW
                     DLAAAWVVLPAGGAARFFDVYAHADEATVRRARGLAALKSLFLMLMGQNGDRGLPGGKP
                     TWGPAGRAALDRVLHMGRERS"
     gene            complement(7022..7471)
                     /locus_tag="HEP86_RS03225"
                     /old_locus_tag="HEP86_03225"
     CDS             complement(7022..7471)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (0-143). E-value:
                     3.4e-24. Score: 77.8. Matches aSDomain:
                     nrpspksdomains_HEP86_RS03225_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091417.1"
                     /locus_tag="HEP86_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03225"
                     /product="SRPBCC family protein"
                     /protein_id="WP_168477117.1"
                     /transl_table=11
                     /translation="MHTYDVTVTTSASPETVWKLLVDAASWPRWSKVDSLDTTRSVDLD
                     PGGDDGVGAVRAFRTGRVVTGERLTEKVERRLLAYEDAFNSSMHHYHARIELKPTASSG
                     TVIHWYGEYETSWLMGWVMPRYLQKFMQGMADGLARYAEERKPDQ"
     aSDomain        complement(7043..7471)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS03225_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.40E-24"
                     /label="HEP86_RS03225_Polyketide_cyc2.1"
                     /locus_tag="HEP86_RS03225"
                     /protein_end="143"
                     /protein_start="0"
                     /score="77.8"
                     /tool="antismash"
                     /translation="MHTYDVTVTTSASPETVWKLLVDAASWPRWSKVDSLDTTRSVDLD
                     PGGDDGVGAVRAFRTGRVVTGERLTEKVERRLLAYEDAFNSSMHHYHARIELKPTASSG
                     TVIHWYGEYETSWLMGWVMPRYLQKFMQGMADGLARYAE"
     gene            complement(7538..>7696)
                     /locus_tag="HEP86_RS03230"
                     /old_locus_tag="HEP86_03230"
                     /pseudo=""
     CDS             complement(7538..>7696)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492752.1"
                     /locus_tag="HEP86_RS03230"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03230"
                     /product="DUF664 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GCTDLGAPVPRPRSDRPTPSIRWALTHMIEETGRHAGHADILREL
                     IDGTAGR"
     gene            complement(<7697..7891)
                     /locus_tag="HEP86_RS03235"
                     /old_locus_tag="HEP86_03235"
                     /pseudo=""
     CDS             complement(<7697..7891)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973884.1"
                     /locus_tag="HEP86_RS03235"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03235"
                     /product="SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTNNAVAFWDGVYAARPAADGPQPNVRLAEMVTDLPPGDALDLG
                     CGDGGDALWLARLGWHVTAV"
     gene            7979..8575
                     /locus_tag="HEP86_RS03240"
                     /old_locus_tag="HEP86_03240"
     CDS             7979..8575
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091414.1"
                     /locus_tag="HEP86_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03240"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_168477119.1"
                     /transl_table=11
                     /translation="MDRSTDDEVLDAVGPRLRTLRRDRGITLAALAATTGVSESTLSRL
                     ESGQRRPSLELLLPLARTYDVPLDDLVGAPRTGDPRIHLKPIARFGMTFVPLSRQPGGV
                     HAFKMIIPARPEPLEPTPQTHEGFEWLYVLNGRLRLVIGERDLTLPPGEAAEFDTSLPH
                     WLGSADGGVVELLILFGLQGVRAHVRTDSAPHRSL"
     gene            complement(8655..8963)
                     /locus_tag="HEP86_RS03245"
                     /old_locus_tag="HEP86_03245"
     CDS             complement(8655..8963)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573807.1"
                     /locus_tag="HEP86_RS03245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03245"
                     /product="hypothetical protein"
                     /protein_id="WP_168477121.1"
                     /transl_table=11
                     /translation="MAKLYLEKLKCVTTEGWSGSDEPRLVVQNRGTVWNGTVLGDRMYT
                     VKYDCDFTGTIAVSLGEAGGTAGDGRPGEQWITDTPGERSLRFRADGAEYNLLYAVE"
     gene            9267..9914
                     /locus_tag="HEP86_RS03250"
                     /old_locus_tag="HEP86_03250"
     CDS             9267..9914
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS03250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_03250"
                     /product="hypothetical protein"
                     /protein_id="WP_168477123.1"
                     /transl_table=11
                     /translation="MDIGSVKAPSKFAWVAVDSLEPAAVACGDDPEGAVQALSQSLAHE
                     GRAVLAVEAPMAIPVPAPDSDAWRVLGRARSGEGNRPWSAAAGAGALATGVAQTAWMLS
                     RLHALAPESSATTRPERFAAGQARLLLAEAFVSGTGKPVPVAAGQHAADAEAAARATLT
                     YLTDGPDGFPYITCAPQRTLNLLALLASWAGMPVPGDELHLDVTVIRTKPVA"
     gene            complement(10001..11530)
                     /locus_tag="HEP86_RS03255"
                     /old_locus_tag="HEP86_03255"
     CDS             complement(10001..11530)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093192.1"
                     /locus_tag="HEP86_RS03255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03255"
                     /product="DUF4334 domain-containing protein"
                     /protein_id="WP_248000986.1"
                     /sec_met_domain="T1TS (E-value: 4e-09, bitscore: 35.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTSRPLGHPPREIVSIADTCSTALQSMPRLEIWLKELGLPVDPA
                     LVPLMCLQTAFFTPWLPPETCYQLARLTVWLMAIDNVLDAPDAADAATRTGPDGAPTRV
                     RAWHRVLAGHDNDGVSEGVSDRDSDGVSDGVSDDPIARALAEIARDLDREGRPELTAVW
                     RKSMHQTLIGMQWEREAARTAAAGRGVTGLTDYLRHGAWTIGVEQQVTALWALMDEPGL
                     SRRLPLLLGALREAATAIRLLNDLRGHQREQSEGKTDALALGLTEQEVSRRAEAGLENC
                     RRALAPLTAAGYGSAVALERVALWHARMYHHFDPVRPGQAATAPLPGGSGSAAPARHSP
                     FVPQPREAPAMSIEQEVLDVIASGGQCDNTKLTELFDRLEPVDTDLLIGTWQGGGFEHT
                     SENAALLAKMRWYGKRFVDADHVEPLLCRDEDGTVFSYEEMGLATLREVVHRGKQSTAM
                     VYDQLPIIDHFRRLTDNVLLCVMDKKESPTDFFFHLTRAPASLPGSAIDGS"
     misc_feature    11717..11732
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            11891..13423
                     /locus_tag="HEP86_RS03260"
                     /old_locus_tag="HEP86_03260"
     CDS             11891..13423
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.4"
                     /locus_tag="HEP86_RS03260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03260"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_168477125.1"
                     /sec_met_domain="T2TS (E-value: 1.4e-35, bitscore: 121.7,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRALALATRHTLSTQRDNGSWLATPAPRITETALCTLALARSPH
                     LGAVRAAERGRAWLAHGAAPQNHHPVAHAVETALLSLALDTGGPIDVSHPFFADRALSA
                     RARLLQALALYTGRATSGATGPAALRTQLATAVAAQGQLKRWTRVELWSAHALVETHFG
                     DRIAARHAARMVADQQSPSGDFFGNPVTTALAALALQAADPGTAAARRCAEYLLTSQLP
                     DGTWRFSTSDVWDTALTIRAFHGATAFERHGLPSAVAFLVAAQNRDGGWPYRLGVESDN
                     DTTAAVLIALGGASGAPGTTLRAGLHHLARQQTTDGLWRTWQSAGDPPVDDVVAHVVTA
                     LDRHSDRHRVQLAAARDWLAERLREQGCWHPGWYRGLPYATAEVLPAFAAAVPEGGHPA
                     ARTLATCRNPDGGWPVEVTGPSTPAATGLALTALEHGGLLHEEHWAPGLGYLVENQRDD
                     GTWPGVPLMYGPRPLLTHYPTHTQAFAVGGLLAGQRRLHQAVGPTASAHKED"
     gene            13425..14843
                     /locus_tag="HEP86_RS03265"
                     /old_locus_tag="HEP86_03265"
     CDS             13425..14843
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543110.1"
                     /locus_tag="HEP86_RS03265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03265"
                     /product="cytochrome P450"
                     /protein_id="WP_248000987.1"
                     /sec_met_domain="p450 (E-value: 1.1e-71, bitscore: 240.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWPGTTRSGRGRSGARLTGGPGHTDADAPTGAPVAPGRVPLAGHA
                     PWFHRDALRFVRGLRHHGPVTRIYIGPRQVHTVNSPEIVRELLTVQARAFDKGAMFDAL
                     REPLGDGLITAAGDRHLRHRRLMQPAFHHERIAGYARIMSERSLARAAAWEPGTTLDLV
                     PEIHHLTLDILLRTLFADPQDPELRTAVRDWLSVKYHAMRLALSPLQAWAERLPLPVGW
                     RPPQAGPLRRLVAVQHRIIETYRADGRDRGDLLSMLLATGGPDGSLTDAAVTDELITLF
                     LAGTGTVSASLAWALYEISRRPDVQRRIHDELDTVLAGRPPGIEDLPALVHTRRVLTEV
                     LRLHPPSWLLMRRAVRPVTLGGVSLSPGAEVFFSPYALHHDPQLYENPDDFEPERWSHA
                     DAAKTSRHTYLPFGAGSRLCIGEDFAWTELMLALVAFTAHRRLTPADSTPVRALVGTVL
                     RPDRLPLTAHARPS"
     gene            14914..15681
                     /locus_tag="HEP86_RS03270"
                     /old_locus_tag="HEP86_03270"
     CDS             14914..15681
                     /NRPS_PKS="Domain: PKS_KR (14-178). E-value: 6e-11. Score:
                     34.5. Matches aSDomain:
                     nrpspksdomains_HEP86_RS03270_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102860.1"
                     /locus_tag="HEP86_RS03270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03270"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_168483516.1"
                     /sec_met_domain="adh_short (E-value: 1.1e-34, bitscore:
                     118.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 9.7e-30, bitscore:
                     103.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDGGPQPGRLRDRVALVTGGASGIGDACARRLAAEGAVVVVADL
                     DEDGAARVARQITAAGGTALARRIDVTDPDSVTRVVTEAATLRDGLRIAVNSAGINGPL
                     SPLAELPPADFDTVMRVNLYGVFHAMRCQLPAMATTGGVIVNLASIAAHAAFRGHAAYA
                     AAKQGVLALTRTAAREYADQGIRVVSVSPGVVDTPMVTSLPPGATDRLLTTVPLRRTAQ
                     PAEVAALIAFLVSDDASYVTGSDHVVDGGYLAK"
     aSDomain        14956..15447
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HEP86_RS03270_PKS_KR.1"
                     /evalue="6.00E-11"
                     /label="HEP86_RS03270_PKS_KR.1"
                     /locus_tag="HEP86_RS03270"
                     /protein_end="178"
                     /protein_start="14"
                     /score="34.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGGASGIGDACARRLAAEGAVVVVADLDEDGAARVARQITA
                     AGGTALARRIDVTDPDSVTRVVTEAATLRDGLRIAVNSAGINGPLSPLAELPPADFDTV
                     MRVNLYGVFHAMRCQLPAMATTGGVIVNLASIAAHAAFRGHAAYAAAKQGVLALTRTAA
                     R"
     CDS_motif       14962..15039
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HEP86_RS03270_0001"
                     /evalue="9.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="HEP86_RS03270"
                     /protein_end="42"
                     /protein_start="16"
                     /score="18.3"
                     /tool="antismash"
                     /translation="LVTGGASGIGDACARRLAAEGAVVVV"
     gene            15797..15967
                     /locus_tag="HEP86_RS03275"
                     /old_locus_tag="HEP86_03275"
     CDS             15797..15967
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HEP86_RS03275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HEP86_03275"
                     /product="hypothetical protein"
                     /protein_id="WP_168477127.1"
                     /transl_table=11
                     /translation="MNKRRLIHWSIRGPAAAGDHDQASHPAFRDLTAETGTRVHHLPPA
                     LARATNREIQP"
     gene            15964..16347
                     /locus_tag="HEP86_RS03280"
                     /old_locus_tag="HEP86_03280"
     CDS             15964..16347
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843941.1"
                     /locus_tag="HEP86_RS03280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03280"
                     /product="VOC family protein"
                     /protein_id="WP_168477129.1"
                     /transl_table=11
                     /translation="MSTPDELAGVRYIVDDVAAAVHFYTTHLGFTLHTHPAPAFADVVR
                     GPLRLLLSGPESSGARATPDDAGAPGRNRIHLLVDDLDTEIDQLRAAGLSFRSDVIAGP
                     GGRQILLADPAGNLIELFEPAPR"
     gene            16557..17804
                     /locus_tag="HEP86_RS03285"
                     /old_locus_tag="HEP86_03285"
     CDS             16557..17804
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744264.1"
                     /locus_tag="HEP86_RS03285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03285"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_168477131.1"
                     /transl_table=11
                     /translation="MRTTVKCRRTRSVGALTATVTAAGLLLTSCGGDGSPPRPTKGSGK
                     TTLTEMDYYISEPGRSALAKQLTRCGALAGVSIKRQIVPDLRTKVLQLANSRALPDLIL
                     LDNPDLQQLAATGALVDLGAAGVKTDGLYPNIVASGKYRGKTYGVAPGVNQLALYYNTS
                     MLAKAGVKPPATWDELRIAARKLTQDDKVHGIGFAVPATEEGSFQFESFFFSAGASLKK
                     LDSPEAVSALTLLKDLVSSGSAPKDVLSWNQMNVGEQFTNGSLAMMINGPWEIPLLRKA
                     GMKDFGIVPVPAPAGRTSSGALGGEVWAAGSSGAKSRKAAEVIKCLVSKGNSLEWAKLT
                     NYVPSDPKVAAEFSAAVPTMKTFVETIGSAKSRTAEVGPDYPKYSQALWTAVQAALSGS
                     KSPGAALTDAQKQATQ"
     gene            17866..18834
                     /locus_tag="HEP86_RS03290"
                     /old_locus_tag="HEP86_03290"
     CDS             17866..18834
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020137266.1"
                     /locus_tag="HEP86_RS03290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03290"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_248000988.1"
                     /transl_table=11
                     /translation="MVPAAPKNSAAVVGGKRPPPDRSVAPAARNRRLGIGFIVPVVVFV
                     AVFYLYPLARNVVLSFQDYDINSLYSGNAPFIGLGNYRRLLSTPAFATAVVNTVVFVAG
                     SLFFQFTIGLGLAEFFRHSFPLSPLLRSLMLIPWLLPLVVSGTLFRWLLDTSNGVVNQI
                     LLTLHLIQAPVPWLNTPHTAMAAVLICNIWIGVPFNMVILHSGMQAIPAELYEAASLDG
                     AGRRQQFRYVTLPQIGPVIGIVVTLGLIYTLKVFDVIWVMTKGGPANATHTITTYAYQL
                     SFGGLSEFGLGAAAGDLLIVVAAVFALLYLRALRADPGARA"
     gene            18945..19715
                     /locus_tag="HEP86_RS03295"
                     /old_locus_tag="HEP86_03295"
     CDS             18945..19715
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010270263.1"
                     /locus_tag="HEP86_RS03295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03295"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_248001560.1"
                     /transl_table=11
                     /translation="MLFPLYWMVNASFQTNQQLARPSPHWLPLGGTLNGYRDALSQQGG
                     HLLASLIIAAGATALTLTLAAPAAYALAQLRSPGGRTLLSVLLVVQLVPGIVMANALYR
                     IFASVQILNSALALILADATLAVPFAVLILRAFMTAIPRSLLEAAALDGAGVLRTFWRI
                     VLPISRNALITSGLFAFLFAWGDFLFATTLNLNTTTWKPITLGLYDYIGGGTNITIWNS
                     VMATAVISALPAALLLTIAQRHIAAGVTNEAVRD"
     gene            19789..21855
                     /locus_tag="HEP86_RS03300"
                     /old_locus_tag="HEP86_03300"
     CDS             19789..21855
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019434488.1"
                     /locus_tag="HEP86_RS03300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HEP86_03300"
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="WP_168477135.1"
                     /transl_table=11
                     /translation="MSPPDGTRPAPSAATSDAAGTSSRTPAFSPPAVCLEFGDAEHVLR
                     VEPWGADSVRVRSARHRVRDGLPGALSAPPAAVAAELGVGPDGSRILTVGRLRVELSPQ
                     GHLRFARTQDGTELLRESVGHFAWPGPRTFTPVGEGRYQLAQRFAAYDGEQFFGLGQHS
                     HGRLDHKHLVIDLVQRNGEVTIPFTLSSRGYGLLWNLPAVGRVELAANQTRWVADAADQ
                     IDYWITTGPAPAAIMANYADATGHAPVLPEWALGLWQSRLRYRTQEELLDVAREYRRRE
                     LPLSVIAVDFFHWPHLGDWRFDATDWPDPAGMVAELASMGVRPLVSVWPSVSFVSENYR
                     HMRDEQLLLGTEHGQPFQHVFPDTQVGDKPLPVVFYDPTDERARDYIWSRIKRNYYDLG
                     FRLWWLDACEPEMYPEQFGNLRYAAGPGRAVANLYPREHVRGFFEHMRAEGEDVPVSLV
                     RSAWSGSQAYGAALWSGDIPATFEALAAQVCAGLSAGLSGIPWWTTDIGGFHGGDPDDP
                     DFRELLIRWFQFAVFCPLLRMHGHREPRDAIPAGHSGGPNELWSYGQDAYRILTRQLRL
                     RQDLRAYLHRQMVSAADSGAPVIRPLFFDFPGDPAAWTVEDQFLCGPDLLIAPVTRLGE
                     RRRRVYLPAGADWRAATTGTDHDGGQTITADAPLESIPVFVRRGSTLEVRFPG"
     misc_feature    22097..22111
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.88"
                     /tool="antismash"
ORIGIN
        1 cgttgtcgaa catgccgggc gagcggcggt agacatcgtg tgtcgtcgcc gaaccgccgt
       61 cgagactcac gatgacctgg gcgagccccg cttcggcgag ctcctcgatg cgccggggca
      121 gcatcatccc gttggtgatg atcgacatcc gcatcccggc ggcggtgccc cggcgcacca
      181 actcggcgac gtccgggtgc atcagcggtt cgccgccggt gaagcggacg tagcccactc
      241 ctgcctcggc ggcccgcggc agcagctcat cgaagtcgtc cagcgagaac cggtaagtgt
      301 cgcgggacag cgcgaactca cacatgaagc agtcggcgtt gcaggcctcg agaatgcgga
      361 cgaacagata cctctgacgt gcgcgcgtgc ggtgccccgc acctgtcggt ccagccatgc
      421 gcaagccttc ctgtgacgag tagttgggca gtgcggagcg tgatcagccg gagaccgcac
      481 cagatgtagg ccgcgcgagc gccagcacat ggccggcgac ctggcgggcg ccgccgctgc
      541 cgacgccgcg ggccaggccc gaccagtcgg cgccggcccg tgcccgctcc agggccgcca
      601 gcacaccggc ccccaccgcg gtctccgcgc ggtccgggct cttggccgcg gcggagatac
      661 cgccgtagat ctggcgcagc accgcctcct cggaggaggt gcggtcccgc agcaccgcct
      721 cctcgcagaa gacgtcgtcc ggccagcgga ccctggtgtc ggccgcgacg gctctgctgt
      781 ggaagcggcc gttgaagatc tggctcaggt tctggggcgg cagacacacc accggtgtgg
      841 accgtgcgcc cgcctccagg agtgtggtga gaccgggcga ggtgagcagc acgtccgcgt
      901 ccgacacatg gcggaggaat tccgcgtggg gcagtgcccc gtaggtgact ttcatcgacg
      961 ccccgtccac cggatgcgag gcgcgcaccg gctcccgggg gaattccggc ggaagattgc
     1021 cggccacatg gacctcgctg aatcctgccc tttccagagc gttcagcgcc gcgggaagga
     1081 cgacgcgtgg atagctggtc cagtccgtga gcgtcggaga ccgcagtccg ccgaagctga
     1141 ccagtgcccg ctggaagggg cctgcggcgg gcgacgcatt gccggggtgc gcgccctgcg
     1201 ttccggagtt ctccaggacg acggcttcca cccattgcag attgcgtacg gcggcgagga
     1261 ggtcccggct gtgcggctcc agttcgatgc agcgctgagc gcagtagacg gagacatcga
     1321 gcgggagcga ggggagatcg cttcgagtcc acaggaacgg caggctgtcc acgaacaccg
     1381 tcgggacgcc ggccgcctcc agcgacgagg ccgcgggccc ttccaggacc acgagcccgg
     1441 cggagacatt ctcgcggcgt gcgacctccg cgacggcctc gcggtcgtcg gttgccacgt
     1501 cgtaccactg gtcgaccccg tgtgcggcga gcagggtacg gctgagccgg gaagcgagcc
     1561 cgacgaaccg cagcggcacg ggcgcggatc gacggagctc ggctatcacc gcgcacagtt
     1621 ttccggtgct tccccacccg aattcggccc cggcgacggc gatcgtcagt cctgaattcc
     1681 gtaggccgat ggaagagttc accgctgcga gtacatcggc catggggctc ctcaggtgtg
     1741 ggggtccgtc acgccgcaga tccgggacgg ggctgaagat ctcgacgagc acaactcatc
     1801 acgcgaacct gacatctccc tggcaggcac ctgccaacga cctgatgtgg cgcaggtcac
     1861 aggatgaggc ggctcctgcg ccctacgggc ccccgacccc ctcccccgcg ccgagccagt
     1921 agccgaagcc cttacgggtg tggatcaagg ggggagcctc ccggtcgacc ttgcgccgga
     1981 ggcgggagat gagcgactcg atggtgttct cggtgcgggc ccggtcctca ccccacacat
     2041 tccggctgat ctgctccttg gacaggacct gccccgggtg gagcaagagg cagcgcagca
     2101 gccggtactc cgtgggagac agactgagct ctcgcggtcc gcgccacacc tgacacgtgg
     2161 cgtcgttcag gatgaggtcg cccagggtga ggtcggcggc ttggcgcggc gtgcgctccg
     2221 gccgtgcggc tccccggtcg tgcagcagca cctgcactct ggccagaatt tccggcacgc
     2281 gcagcggttt gaggacatag tcggcgacgc cgagactgag ccatgggcac aggccatcca
     2341 gtgacgtggg atccgtcagg aacagcaccg gggcgctgcc gtcagccagg cgctgatacc
     2401 ccgccaggtc gtgcgcgtcg ggcatcaggg tgtcgatgat cagcaggtcg aaccgctggg
     2461 cggccagcag caccagcgcc gcggccctgg tgctggcccc ggcggcctga taccccgcca
     2521 gctccagact ctccaagacc ttttcggatg ttgccaccgg gccgaggacg attaaggacg
     2581 cctgccgatc gccgctggcc ggagggaact tctcacggga agtcaggtgc atggagttct
     2641 gcttccttct gcgtgggttc gtcattgggg gtccgggagc cgggtggctc atcggcctgt
     2701 ttcgctccat gaggtgatgc tgtgttcctt gacgcgccgg tggcgtcgca gggtgagtgc
     2761 atcgctgaac tgggcgacag cttcggtgaa ttccatggcg atcactgggt gccgtgtgca
     2821 ggcggtgccc accacggtga tgtggtgccg gtccgcgatg acggggtggg tgtggtcgac
     2881 tccgagtgcg gtcagggccg tcgtgagctg gtcggtgtcc tgagatgacg gcagcccgaa
     2941 aggagtcggc ccggacgggc tcgggtgatc ctgctgctca gtggtcaggc cgagaacgga
     3001 agaaaagtcg gaccagcggt gcagccagac ggccttcttc gcgtccctgc cgggttcctt
     3061 cagggcgctg atggaggcgt cggcgaaggc cgatgtatgg ggctccgtgc caatgagacc
     3121 gtcgacgagg ccgaggcggg ccctcgcgat gcgctgggca gggggcctgg cgcaggcgcc
     3181 ctcagagcac ggtcagccgt tcatagggct cggtcggcag gtgcgtgtcc agcaccggag
     3241 ccgttgatgg gctcggcgag ccgcgcgaga agtccctgct tgttgccgag gtgccaccgc
     3301 atggagttgt gctggacggt caggcagtcg gcgacggctc ggagggtcaa cgcaccggct
     3361 tgttgtggct accgtgcagt ggacacggcg ggccgcttgc gcagcaggct gacggtgaga
     3421 agcgccagct ccgttgccag ggcgaccgcg gccagcacgg tctgccaggc cggaccggct
     3481 gaggcgaggt tggtcaccag gtagcccacg aggaggacag cgagtgccgc cgcctgagcg
     3541 tcaggacgca tccaccaccg cgtgcggggg acgctctgcc cctcggcaac ttggagcgcg
     3601 tacagctcga cgggaccgaa ctcctcctgg ggagaacacc ctgtggcggt gaggtgatgg
     3661 gcggcctccc tggtgagttc ggcggcccgg gcgcgggaca gtccgtgccg ttcctcaagc
     3721 agccggggca gctcaaccag ccagttctcg ggcagtagtt gagactccga ggtgagttcc
     3781 ttgtggtcag ggcccggctt gtagcgtgcg gccgaccaga gcagcaggac acccagcgca
     3841 cacagagccg ggacgggaag ccgaccgtag gaggccgtcg gcaggtaggt gaaggccccc
     3901 gccgacagca gcaacgcggc aacggcgccg actccccagc ggacggcacc ccgggccctg
     3961 gaactcgcaa gggtcgccgt caggcaggcg ctcggtatcg ccacgccaag gagcgcgctg
     4021 ccggccaccc cggcaggggt cacggtcagc atcgttccgt ccccgaccca catacaaacg
     4081 ccggccacaa ggacggccac ccccgtctga gcgagagcgg cggagacctg gtccgcgcgg
     4141 gtcaggccgt cccagttccg gccggtgcgc tcctcgggcg gtatgcggtc gcgagccacg
     4201 gcggccgcgt acttctccgg tgcaccgaag gcgtcctcgg gcgtctcacc ggactgcgcg
     4261 cagtgcaggt ccacctcatc gagcaccatg tcggcggtgg ccgagtccac cgactgcccc
     4321 gccagcgcca gcctcgcccg agctttccac cgggaagtca agtccgtcac cactcctcct
     4381 tcgttacctg ctccagcagc cggtccatcg agtcggagaa ccgctgccac gtcgcggtct
     4441 cctcgagcag tcgagcccgt ccggcgtcgc tgagccggta caccttgcgg cccggcccgc
     4501 cttccccggg ctcccaacga gcttccacca gcccttcggt ctccatccgg ccgagcaccg
     4561 gatacaacgc tcccccgcgg atggtgccga atccgtgggc ggccaactgc tgcaccagcg
     4621 catagccgtg ctgatcgccc tgcgccagca cggcggcgag cgccagcggc agcacacccc
     4681 gcagccagcc cgatgagggt tccttcacag gcatcccgta gtcacgccaa ccctctactc
     4741 caaatctcga ctagttcgat ttcagagtag tgaccttccg gcgccgcgtc cagtagcggg
     4801 cacctcaacc ggcgcaggtg ggagcgcagt tgacgcacgg cggtccaacc ggcaggtagc
     4861 tgggcatgac gctctgggtg ttggactgcg aggtcgactg cgggcaggac tgcggtcggc
     4921 cgcttcatgg gtggtcgctc ctgacaccgt ccgccgggac cgcaccccgg accgccttgg
     4981 ctcagcccag cgcgtccatc agggcggtga cgtaggcatc cagccgctcc cccacggctc
     5041 gcgtcgtcag ctcagtcctc ccagcctcac gccatggccg cgccacctgc tgcacttctt
     5101 ctgagcacgc cagcccgtcc cgcacctgcc agtacagccg ctcgctcgcg gcctcggcca
     5161 gcaccccgcc ggcctcctca tacgccgcag cgaaccgcag accccacgcc tggccgtgca
     5221 gcagcgcgag gttggtggag cagtgcgcca catcgagatc cgccgggccc caggatgtcg
     5281 ccgcccagtc gatgacgccg gtgatccggg cacctgccgg tctcgcgggc gggacatcga
     5341 acagcacgtt gccgggttgg aagtcccggt gcaggaatcg cccttcgtag ggcggcgcgg
     5401 gcctgcggat cacgtcgatc gccgcggccc ataccgccgc gtcggccccc ttcggaacca
     5461 cgacggtgtc ggcggtcgtc aacgccacat actcccgggg ccgctcggcg ggtcgcagcg
     5521 cgtggatcgc gacgagttga cgggccagca gaggaacgcg cgtctccaac ccctcatcgt
     5581 cgagaaccgc ccggcccgcc agatgggtca tcaggagcga cggatactcg ccatgcgcgg
     5641 cggtcggatc aaccgcgacc agtccaggag cgggcacgcc ggtccccgtg agcagggcca
     5701 gggcgccggc ctccctgttc agccagtcct cggcgtgccc cacggagaac gggtcgacga
     5761 agctccgcag caccaggtca cgggtgcctc cgtcccgcgt gccgatggtc agcctccgca
     5821 tttcggcagt gatgccgccg tgcagtgcct cggtcctgac gatccgttcg ccggcctcca
     5881 ggtgccggct cacccaagcc agggtcaacg gtcggacagc cgccgcctca tcgtggttgg
     5941 tcaccgggct acttcatcac cccggacggc ggcacgcgcg agggtttcat gcgagagggc
     6001 gccggcagtc agtcgccgca cagcaggatc gtccagccgc ggctcacgag cggagccaga
     6061 gttgccgcct gccccagtac tgtggcttcg tatgaccgac tccgagagcg agatcaccgc
     6121 agacctggtc catgacctgt tgcgggagca gcatccggac ctggcaggac tggccatccg
     6181 cgaagtagcg ggcggctggg acaaccagca gtggcgcctt gggaacgagt tggctgtgcg
     6241 catgccgcgt tcagaccgtg ccccggacct ccagcgcaag gagtgccggt ggctgcccgt
     6301 cctggccccg cgcctgccgc tcccggtccc gaaccctgta cggatcggtg caccgtccgc
     6361 gcgcttcccg aagccctgga ccatcatgac gtgggttccc ggcgaaccac tggacgtcac
     6421 ctcgatcagc cgcactgacc acgcggccga cactctggcg gacttcctca cagcgctcca
     6481 cgtggaggcg cccgctgacg cgccgatcgg tgcggaccgc ggcgcccacc ccaaaaagta
     6541 cacggagggc ttcgactact tcttgcaagc cgttgccctc gacggcgtcg ccgacgaggt
     6601 ccgggccgtc tgggatgacg ccgtcgcggc ccccgagtgg gaaggcccgc cggtgtgggt
     6661 gcacggtgac cttcatcccg ccaacgtcgt cgtctcggac gggacgctct cgggagtggt
     6721 cgacttcggt gacatgtgca ccggcgatcc cgcgtgggac ctcgcggccg catgggtggt
     6781 ccttcccgcc ggtggcgccg cacggttctt tgacgtgtac gcgcatgcgg acgaggcgac
     6841 ggtccggcgc gcccgcgggc tggctgcgct gaaaagcctg ttcctcatgc tgatgggcca
     6901 gaacggagac cggggccttc ctggcggcaa gccgacatgg ggacccgccg gccgggcagc
     6961 gctcgatcgt gttctgcaca tggggagaga gcgaagctga acgcacgctg cggcgccgtc
     7021 atcactgatc cggcttgcgc tcctcggcgt aacgggccag cccatccgcc atgccctgca
     7081 tgaacttctg gaggtagcgc ggcatgaccc agcccatcaa ccagctcgtc tcgtactcgc
     7141 cgtaccagtg gatgaccgtg cctgaactcg ctgtcggctt cagctcgatg cgcgcgtgat
     7201 agtggtgcat cgacgagttg aacgcgtctt cgtaggccag gaggcgtcgc tcgaccttct
     7261 cggtcagccg ctcccccgtc acgacgcgcc ccgtccggaa ggcccggacg gcacccaccc
     7321 catcgtcgcc accggggtcg aggtcgaccg accgagttgt gtccagactg tccaccttgg
     7381 accaccgcgg ccagcttgcg gcgtcgacca gcagcttcca gacggtttcc ggcgaggcgc
     7441 tggtagtcac cgtgacgtcg tatgtgtgca tgggagaggg ctcctgtgag tggatgcggg
     7501 cggcgtcccc ggccaagagg acgcggtcga cgcgggatca gcggccggca gtgccgtcga
     7561 tgagttcgcg gaggatgtcc gcgtggcccg catgtcggcc ggtctcctcg atcatgtggg
     7621 tgagtgccca gcggatgctg ggagtggggc ggtccgaccg cggtcgggga accggtgcgc
     7681 ccagatcggt gcacccgacg gcggtgacgt gccaccccag gcgggcgagc cacagcgcgt
     7741 cgccgccgtc gccgcatccg aggtccaacg cgtcgccggg cggcaggtcc gtcaccatct
     7801 cggcgaggcg gacattcggc tgcgggccat cggctgccgg tcgggccgcg tagacgccgt
     7861 cccagaacgc gaccgcatta ttggtgctca tcaaggctcc tcgtgtcggt atgcgctcag
     7921 tcttgccagg caccgcacga tctggcacgg aatcttgcgg ttacggcaag atggtctgat
     7981 ggatcgcagt acggacgacg aagtgctcga cgcggtgggg ccgcggcttc gtacgctgcg
     8041 tcgtgaccgg ggcatcaccc tggccgccct cgcggcgacg accggcgtat cggagagcac
     8101 gctgtcccgg ctggagagcg ggcagcgtcg gccgagcctg gagttgctgc tgccgctggc
     8161 ccggacctat gacgttccgt tggacgacct cgtcggcgcc ccgcgcaccg gcgacccccg
     8221 gatacacctc aagccgatcg cgcggttcgg gatgacgttc gtgcccctgt cccggcagcc
     8281 gggcggggta cacgcgttca agatgatcat ccccgcccgg cccgaaccac tcgaaccgac
     8341 cccgcagaca cacgaaggct tcgaatggct ctacgtcctc aacggacgcc tgcggcttgt
     8401 gatcggcgag cgcgacctga cgctaccgcc gggtgaggca gccgagttcg acacatcctt
     8461 gccccactgg ctgggcagcg ccgacggcgg cgtggtcgag cttctcatcc tgttcggcct
     8521 gcaaggggtg cgtgcgcacg tacgtaccga cagcgcccct catcggtcgc tgtaggcggc
     8581 gccgcgatca caccagccac cggccatcgg ccacaagatc gtctcatcgg tggccagcag
     8641 ctacgggaca acccttactc caccgcatac agcaggttgt actcagcacc atccgccctg
     8701 aagcgcagac tgcgctcacc aggcgtatcc gtgatccact gctccccggg cctgccgtcc
     8761 ccggctgtgc cgccggcctc cccgagagag acggcgatcg ttcccgtgaa gtcgcagtcg
     8821 tacttgacgg tgtacatccg gtctcccagc accgtcccgt tccacacggt gccacggttc
     8881 tggaccacaa gcctcggctc gtcggagccg ctccagccct cagtcgtgac gcacttgagc
     8941 ttctccagat aaagcttggc cataccgtcc cctgtgaagg atccttctcg acacttcaca
     9001 tcctgccgag ccgcaataaa cgatcactaa acgttgggca cggtaaaaat tgcggcaccc
     9061 cggccactgg ctgtcgcccg gccgtccggt gagccgtggt cgcttgcccc aaccggcttg
     9121 agtggagcag gccgtgcggc agactgtgct ggaacatcgc cctgcggggc cgggtttgct
     9181 gggcagctct ggacccgcaa agtgcctcac gaccccggcc tgcgggtcag ccggcaaagg
     9241 gggcagatct catgcgtgtc gtaggtgtgg acatcggctc ggtgaaagcg ccgtccaagt
     9301 tcgcctgggt tgccgtcgat tccttggagc ctgccgcggt cgcctgtggc gacgacccgg
     9361 aaggcgccgt gcaggcactg tcgcagtctc tggcccacga gggacgcgcg gtcctggccg
     9421 tggaagcgcc catggccatt cctgtccccg ctccggacag cgacgcgtgg cgcgtgctgg
     9481 gccgtgcgcg cagcggggag ggcaaccggc cgtggtcggc cgctgcgggc gccggagcgc
     9541 tggccaccgg ggtcgcccag accgcatgga tgctctcccg tctgcatgcc ctcgcgccgg
     9601 aatcgagcgc gaccacccgg cctgagcggt tcgccgccgg gcaggcccgc ctcctgctcg
     9661 ccgaggcctt cgtctccggc accggcaaac ctgtcccggt ggcggccggt cagcatgccg
     9721 ccgacgccga agccgccgcc cgcgcgacgc tgacctacct gaccgacggc ccggacggct
     9781 ttccgtacat cacgtgcgca ccgcagcgga cccttaacct ccttgccctg cttgcctctt
     9841 gggccggaat gccggtgccc ggtgatgaac tgcacctgga cgtgacggtc attcgtacga
     9901 agccggtcgc ctgaaccgcc gtggggcggc ttcgccttgg tacagggcaa aggactctcc
     9961 gtcacgcgtc gagtactggc gctcccccgc tcctcggcca ctagctgcca tcgatggctg
    10021 acccgggcag cgatgcgggt gcccgggtga ggtggaagaa gaagtcggtg ggagattcct
    10081 tcttgtccat cacgcacagc aggacgttgt cggtcagccg gcggaaatgg tcgatgatgg
    10141 gcagctggtc gtaaaccatc gccgtggact gcttgccgcg gtggacgacc tcgcgcaacg
    10201 tggcgaggcc catctcctcg tacgagaaga ccgtcccgtc ctcgtcgcgg cacagcagcg
    10261 gctccacgtg atcggcgtcg acgaaccgct tcccgtacca ccgcatcttc gccagcagcg
    10321 cggcgttctc gctggtgtgc tcgaagccac cgccctgcca ggtgccgatg aggagatcgg
    10381 tgtcgaccgg ttcgagccgg tcgaaaagct ccgtcagctt cgtgttgtcg cactgtcctc
    10441 cggacgcgat gacgtccaga acctcctgct cgatgctcat ggccggggcc tccctcggtt
    10501 gggggacgaa cggtgagtgc cgggcggggg cggcgctgcc cgatccgccc ggaaggggtg
    10561 cggtggccgc ctggccgggc cgtacgggat cgaagtggtg gtacatccgc gcatgccaga
    10621 gcgccacccg ctccagtgcc accgcggaac cgtacccggc cgcggtgagc ggagccagag
    10681 cccgccggca gttttcgagc cctgcctcgg cgcgccggga cacctcctgt tcggtcaggc
    10741 cgagcgcgag cgcgtcggtc ttcccctcgg actgttcccg ttggtggccg cgcagatcgt
    10801 tgagcagacg gatggcggtc gcggcctcgc gcagcgcgcc gagcagcagg ggaagacgcc
    10861 gggacaaccc cggctcgtcc atgagggccc acagggcggt gacctgctgt tcgacgccga
    10921 tggtccaggc gccgtgccgt agatagtccg tcagcccggt gacgccgcga ccggcagccg
    10981 ctgtgcgggc cgcctcccgt tcccactgca tgccgatgag cgtctgatgc atgcttttcc
    11041 gccagacggc ggtgagttcg ggtcggccct cgcggtccag gtcccgggcg atctccgcca
    11101 gagcgcgcgc gatggggtcg tcgctgacgc cgtcactgac gccatcgctg tcgcggtcgc
    11161 tgacgccctc gctgacaccg tcgttgtcgt gccccgcgag gacccggtgc caggcccgga
    11221 cgcgggtcgg ggccccgtcc gggcccgtgc gagtcgccgc gtccgctgca tccggcgcgt
    11281 ccaggacgtt gtcgatcgcc atcagccaga ccgtgagccg ggccagctga tagcaggtct
    11341 ccggaggcag ccaaggggtg aagaacgccg tctgaaggca catgagggga accagcgcgg
    11401 ggtccacggg cagcccgagc tctttgagcc agatctccaa tcgcggcatg ctctgcaatg
    11461 cggtggagca tgtgtccgct atggagacga tctcccgggg agggtggccg agcggccgcg
    11521 aagtgtccac ggcgtcaggc tacgtcccgc gctcgtgcgt gttccggcgc tccgagcctt
    11581 ttcggcccgc acccgggccc gggccggtgc gcctgcccgc agccgcgtcg cctcgccggg
    11641 ccggcggccc ggccacacct cggaccgtcc tccacacggt gcctcacacc gccgcatgca
    11701 tcacacccac ccatgagtca cccatgagtc acggccacgc gtgagtcacg tccacgcatt
    11761 agtcacaccc acacatgagt cacgatcaca aagcgtcagc ggaaccaggg aagacagggg
    11821 tcagatgtca acaggacctg cgttaccgtc cgttccggac gcgcagctct cgcccaccct
    11881 cgccacacgt gtgagccgtg cgcttgccct tgccacccgg catacgctct ccacccagcg
    11941 ggacaacggc tcatggctgg ccacccccgc ccctcgcatc acggagaccg cactgtgcac
    12001 gctggccctg gcacgctctc cgcacctcgg cgccgtccga gccgccgaac ggggccgggc
    12061 gtggctcgcc cacggcgccg ccccgcagaa ccaccatccg gtggcccatg ccgtggagac
    12121 cgcactgctg tcgctggctc tggacaccgg cggccccatc gacgtgagcc atcccttctt
    12181 cgcggaccgg gcgctgtcgg cccgcgcccg gctcctccag gccctcgccc tttacaccgg
    12241 ccgagcgacc agcggcgcta ccggtcccgc cgcgctgcgc acccaactgg ccaccgctgt
    12301 cgcggcccag gggcagctca aacgctggac ccgggtggaa ctctggtccg cgcacgcact
    12361 ggtggagacc cacttcggcg accggatagc cgcccggcac gccgcccgta tggtcgccga
    12421 ccagcaatcc ccgtcgggcg acttcttcgg taatccggtc accaccgctc tcgcggcact
    12481 cgcgctccag gccgccgacc ccggtacggc tgccgcccgc cgctgtgcgg agtaccttct
    12541 caccagtcaa ctcccggacg gaacctggcg cttttccacc agcgacgtct gggacaccgc
    12601 gctgaccata cgtgcctttc acggcgcgac ggccttcgaa cgccacgggc tgccgtccgc
    12661 cgtcgcgttc ctggtcgcgg cacagaaccg ggacggcggc tggccgtacc gcctgggcgt
    12721 cgagtccgac aacgacacca ccgcggccgt cctgatcgct ctgggcggcg caagcggcgc
    12781 gcccggtacg acgctccggg ccgggctgca tcacctggcc cggcagcaga cgacggacgg
    12841 tctctggcgg acctggcagt ccgccgggga cccgccggtg gacgacgtgg tggcccatgt
    12901 cgtcaccgca ctggaccgcc actccgaccg ccatcgcgtg caactggccg cagcgcgtga
    12961 ctggctcgcc gaacgcctcc gcgagcaggg atgctggcac cccgggtggt accggggact
    13021 gccgtacgcc accgccgagg tccttcccgc cttcgctgcg gccgtacccg agggcggcca
    13081 tcccgccgcc cgcactctgg ccacatgccg taatcccgat ggtggctggc ccgtcgaagt
    13141 gaccggcccg agcactcctg ccgcgacggg gctggcgctc acggccctgg aacacggcgg
    13201 tctgctccac gaggaacact gggcgccggg gctcggctac ctcgtggaga accagcgcga
    13261 cgacggcacc tggccgggcg taccgctcat gtacggcccg cgaccgctcc tgacgcacta
    13321 ccccacccac acccaggcgt ttgccgtcgg cggcctcctt gccgggcagc gccgcctcca
    13381 ccaggcggtg gggcccaccg cctccgctca caaggaggac tgacatgtgg ccgggaacga
    13441 cacggtccgg caggggcaga agcggcgcac ggctcaccgg cggaccggga cacaccgacg
    13501 ccgatgcccc caccggagcc cccgtcgcgc ccggccgcgt gccgctggcc gggcatgccc
    13561 cgtggttcca ccgtgacgcg ctgcgcttcg tccgggggct gcggcaccac ggcccggtga
    13621 cgaggatcta catcggccca cggcaggtac acaccgtcaa ctctcccgaa atcgtccggg
    13681 agttgctgac cgtgcaggcg cgcgccttcg acaagggcgc gatgttcgac gctctgcgtg
    13741 agccgctcgg cgacgggctg atcaccgccg ccggcgaccg ccacctccgc caccgccggc
    13801 tgatgcaacc ggccttccac cacgaacgga tcgccggcta cgcccgcatc atgtccgaaa
    13861 ggtcgctggc acgggccgcc gcctgggagc ccggcaccac gctcgacctg gtgccggaga
    13921 tccaccacct gacgctcgac atcctgctgc gcaccctctt cgcggatcct caggacccgg
    13981 aactgcgcac cgctgtccgg gactggctgt ccgtcaagta ccacgcgatg cgccttgcgc
    14041 tctccccgct gcaggcctgg gcggagcgcc tcccgctgcc ggtcggctgg cggccgccgc
    14101 aggccgggcc gctgcgccgg ctggtggccg tccagcaccg catcatcgag acctaccgcg
    14161 ccgacggccg ggaccgcggc gatctgctct cgatgctcct ggccaccggt ggcccggacg
    14221 gttccctgac cgacgccgca gtgaccgacg aactcatcac cctgttcctg gccggtaccg
    14281 gcaccgtcag tgcgtccctg gcctgggcgc tgtacgagat ctcccgccgc cccgacgtcc
    14341 agcggcggat ccacgacgaa ctcgacaccg ttctcgccgg acggcctccc ggcatcgagg
    14401 atcttcccgc cctggtccac acacgaaggg tgctgaccga agtgctgcgg ctgcatccac
    14461 cgtcgtggct gctgatgcgc cgtgcggtgc ggcccgtcac cctcggcggg gtatcgctct
    14521 cccctggcgc cgaggtgttc ttcagcccgt acgccctgca ccacgatccg cagctgtacg
    14581 agaacccgga cgacttcgag cctgagcgct ggtcgcacgc cgacgccgcg aagacgtcgc
    14641 gtcacaccta tctgcccttc ggagcaggca gccgactgtg catcggggaa gacttcgcct
    14701 ggaccgaact gatgctggcg ctggtcgcgt tcaccgctca ccggcgcctg acacctgccg
    14761 actccacccc cgtgcgggcc ctggtcggca ccgttctgcg cccggaccgg ttgccgctca
    14821 cggcgcatgc ccgcccgtcc tgatccgcac ggcacggcct cttccgcctg cccctcccct
    14881 tgccaggagt cacacatgcc ggtgcccgca cagatgtcag acggcggacc gcagcccggc
    14941 cggttgcggg accgggtcgc cctggtgacc ggtggcgcct ccgggatcgg cgacgcgtgt
    15001 gcccggcggc tggccgcgga aggtgctgtg gtggtggtcg cggacctcga cgaggacggg
    15061 gcggcccgtg tggcccggca gatcaccgcg gccggtggca ccgccctggc ccgccgcatc
    15121 gacgtcaccg acccggacag cgtcacccgc gtcgtcacgg aagccgccac cttgcgcgac
    15181 ggcctgcgga tcgcggtcaa cagcgccgga atcaacgggc ccctgagccc cctggccgaa
    15241 ctcccgcccg ccgacttcga caccgtcatg agggtgaacc tgtacggcgt cttccacgcg
    15301 atgcgctgcc agcttcccgc gatggccacc acgggcggcg tcatcgtcaa cctcgcctcc
    15361 atcgccgcac atgcggcctt ccgagggcac gccgcctacg ccgccgccaa gcagggtgtc
    15421 ctcgccctga cccggaccgc ggcgcgcgaa tacgccgacc agggcatccg ggtcgtgtcc
    15481 gtgtcgccag gcgtcgtcga caccccgatg gtcacctcgc tgccgcccgg agccaccgac
    15541 cgtctcctca ccaccgtccc cctgcggcgc accgcgcagc cggccgaagt cgccgcactc
    15601 atcgcgttcc tggtgtccga cgacgcctcg tacgtgacgg gcagcgacca tgtggtcgac
    15661 ggtggctacc tggccaagta gccgacggaa acacggggcg ggaagagcac tctcggcgcg
    15721 gattcggtcg aagggctcat cggttacggt gcggctgtcc cgctatccgc tggcccagca
    15781 tgtcaaggtg ttcgacgtga acaagcggcg actgatccac tggagcatcc gcggcccggc
    15841 tgctgccggc gaccacgacc aggcaagcca ccccgccttc agggacctga cggcggagac
    15901 cggcacccgc gtccatcacc tgccgcccgc cctcgcccgc gccacgaacc gggagatcca
    15961 accgtgagca cacccgacga gctcgccggc gtccgctaca tcgtcgacga cgtggccgcc
    16021 gcggtccact tctacaccac ccacctcggc ttcactctgc acacccaccc cgcgcccgct
    16081 ttcgccgacg tggtccgcgg cccgttgcgg ctgctgctgt ccgggccgga aagctccggc
    16141 gccagggcca cgcccgatga cgccggcgcg ccgggccgca accgcatcca tctccttgtc
    16201 gacgacctcg acaccgagat cgaccaactg cgcgccgccg ggctgtcctt ccgcagcgac
    16261 gtcatcgcgg gccctggtgg acgccagatc ctgctcgccg acccggccgg caacctcatc
    16321 gaactgttcg aacctgcccc gcgctgagct gtttgcgaga accgccagcc gctcacatca
    16381 agatcaacgg aagcactgtc accttcgcga tgatggtgtt ctcacagcac ggtgcccagt
    16441 cgggatgccg tacgggtgtc accccgcgcg ctgcctcatg actcgacgag ctctgcgcca
    16501 caatcccggc atacccagga gcagtgtctg cgcaccgatt tctcgttgga gccgccatgc
    16561 gcaccaccgt taaatgccgt cgcacccggt cagtcggggc tttgacggcg acggtcaccg
    16621 cagccggcct gctgctgact tcctgcggcg gcgatggctc gccacccagg cccacaaaag
    16681 gcagcggcaa gaccactctg actgaaatgg attattatat ttcggaaccc gggcggagtg
    16741 cgctggccaa gcagctcact cggtgcgggg cactggcggg ggtttccatc aagcggcaga
    16801 ttgtgccgga cctgcgtaca aaagtgctcc agttggcgaa cagtcgggcg ctgccggacc
    16861 tgattctcct ggacaatcct gacctccagc agctcgccgc cacgggagcg ctcgtcgacc
    16921 tcggtgcggc cggtgtgaaa accgacggac tgtatccgaa catcgtcgcc tcgggtaaat
    16981 accggggtaa gacgtacggt gtggcgcccg gtgtgaacca gttggcgctc tactacaaca
    17041 cgtcgatgct ggcgaaggcg ggcgtcaagc cgcctgccac gtgggatgag ttgcgcatcg
    17101 cggccaggaa gctgactcag gacgacaagg tgcacggaat cggctttgcc gtaccggcca
    17161 ccgaagaagg cagtttccag ttcgagtcct tcttcttcag cgccggcgct tccctgaaga
    17221 agctcgattc accggaggcc gtgtcggcgc tgaccctcct gaaggacctg gtctcctccg
    17281 gttcggcgcc caaggacgtg ctcagctgga atcagatgaa tgtcggggag caattcacca
    17341 acggttcgct ggctatgatg atcaatggtc cctgggagat tcccctgcta cgaaaggcag
    17401 gcatgaagga tttcggcatc gtgccggtgc ccgcaccggc cgggagaacc tcctccggtg
    17461 cgctcggcgg tgaggtgtgg gcggccggca gcagtggtgc caagtctcgc aaggcagccg
    17521 aggtcatcaa gtgcctggtg tcgaagggaa acagtctgga gtgggccaag ctcaccaatt
    17581 acgtgccgtc cgacccgaaa gtggccgcgg aattcagtgc cgctgtgccc acgatgaaga
    17641 ccttcgtgga gaccatcgga agcgccaaga gccgcacggc ggaagtcggg ccggactatc
    17701 cgaagtactc gcaggcgctg tggaccgccg tgcaggcagc attgtcaggg agcaagtcgc
    17761 ccggcgcggc gctgactgac gcacagaagc aggcgacgca atgagtgccg agccgccgac
    17821 ccgtgggtgg tacacgccga cggccaccct cccggaaaga tagccgtggt tccggcagcg
    17881 cccaagaact cggcggcggt cgtcggcggc aaaaggccgc cgccggaccg ctccgtggct
    17941 ccggcggctc gcaaccgacg gctcgggatc ggattcatcg tgccggtcgt cgtcttcgtc
    18001 gcggtgttct atctctatcc gctggcccgc aatgtggtgc tgtccttcca ggactacgac
    18061 atcaattccc tctacagcgg caacgccccg ttcatcggcc tcggcaacta ccgccgcctg
    18121 ctgagcaccc ccgcctttgc cactgccgtc gtcaacaccg tggtctttgt tgcgggctca
    18181 ctcttcttcc agttcacgat cggcctggga cttgccgagt tctttcgcca ctcgttcccg
    18241 ctcagcccgc tgttgcggtc gctcatgctg atcccctggc tcttgcccct ggtcgtctcc
    18301 ggcacgctgt tccggtggct gctcgacacc agcaacggcg tcgtcaatca gatcctgctc
    18361 accctccatc tgatccaggc cccggtgccg tggctcaaca ccccccacac cgcgatggcg
    18421 gcggtgctga tctgcaacat ctggatcggt gtgccgttca acatggtgat cctccacagc
    18481 gggatgcagg ccatcccggc ggagctgtat gaagcggctt ccctggacgg cgccggccgc
    18541 cggcagcagt tccgctatgt caccctgccg cagatcggcc ccgtgatcgg catcgtcgtg
    18601 acgctcggcc tgatctacac gctcaaggtc ttcgacgtga tctgggtgat gaccaagggc
    18661 ggcccggcaa acgccaccca caccatcacc acctatgcct accagctgtc cttcggcggg
    18721 ctgtcggagt tcgggctcgg ggccgccgcg ggtgatctgc tcatcgtcgt ggccgccgtc
    18781 ttcgccctgc tgtacctgcg cgcgctgcgc gctgatcctg gagcccgcgc atgaccgccg
    18841 cccgcgctgc ccggacccgg cccgcctcgg tccgtggcgg gcggagccgg acggccgtgg
    18901 tcacctgggc gaaatccgcg ttcggtgtcg ccgtcgtcgc cgtcatgctg ttcccgctgt
    18961 actggatggt gaacgcgtcc ttccagacca atcagcagtt ggcccggccg tcaccgcact
    19021 ggctgcccct cggcggcacg ctcaacggct accgggacgc gctctcccag caagggggcc
    19081 atctgctggc gtccctgatc atcgccgcgg gcgccacggc cttgacgctg accctggccg
    19141 caccggcggc ctacgcgctg gcgcagctgc gctccccggg cggcaggacg cttctgagcg
    19201 ttctgctggt cgtccaactc gtgcccggca tcgtcatggc caacgcgttg taccggatct
    19261 tcgcctcggt ccagatcctc aactcggccc tggcgttgat cctggccgac gccacccttg
    19321 ccgtcccctt cgccgtgctc atcctgcggg cctttatgac cgccatcccc cggtccctgc
    19381 tggaggcggc ggcgttggac ggtgcgggcg tgctacgcac cttttggcgg atcgtgcttc
    19441 ccatatcccg caacgcgctg atcacctccg gccttttcgc gttcctcttc gcatggggcg
    19501 acttcctgtt cgccaccacg ctcaatctca acaccaccac gtggaagccg atcacgctgg
    19561 gtctgtacga ctacatcggt ggcggcacca atatcaccat ctggaactcg gtgatggcca
    19621 ccgccgtcat ctccgcccta ccggccgcgc tgctgctgac cattgcccag cggcatatcg
    19681 ctgccggagt caccaatgaa gcggtcaggg actgaccgcg ccgtaaaccg ccacccgcgc
    19741 ccctgcaccg cccctgaccc gtacaacagc cctgtagaaa ggagcagcat gtctccgccc
    19801 gacggcacaa ggcccgcacc ctccgccgcc acgtccgacg cagccgggac cagctcccgg
    19861 actcccgcct tctcccctcc ggccgtctgc cttgagttcg gtgacgccga gcacgtactg
    19921 cgggtggagc cctggggagc cgacagtgtc cgggtgcgct cggcccggca tcgggtgcgc
    19981 gacggcctgc cgggagcctt gagtgcgccc cctgcggccg tggccgcgga gttgggcgtg
    20041 ggacctgacg gcagccggat cctcaccgtc gggcggctgc gcgtggagct gtctccccag
    20101 ggccatctgc gtttcgcgcg tacgcaggac ggaactgagc tgctgcggga gtccgtaggc
    20161 cacttcgcct ggccgggtcc gcgcacgttc acaccggtcg gcgagggccg ctatcagctg
    20221 gcccagcgct tcgccgccta tgacggtgaa cagttcttcg ggctgggcca gcactcccac
    20281 gggcgcctcg accacaagca cctggtgatc gacctggtgc agcgcaatgg ggaggtcacc
    20341 atcccgttca ccctctcctc ccgcggctac gggctgctgt ggaacctgcc cgccgtcgga
    20401 cgtgtggagc tggccgccaa tcaaacccgg tgggtcgccg acgccgccga tcagatcgac
    20461 tactggatca cgaccggtcc ggctcccgcc gcaatcatgg ccaactatgc cgatgccacc
    20521 ggacacgctc ccgtgctgcc ggaatgggcc ctgggcttgt ggcagtcccg cctgcgttac
    20581 cggacacagg aggaactgct ggacgtcgct cgcgaatacc ggcgccggga acttccgctg
    20641 tcggtcatcg ccgtggactt cttccactgg ccgcatctgg gcgactggcg cttcgatgca
    20701 accgactggc ccgacccggc cgggatggtg gcggaattgg cgagcatggg cgtacggccg
    20761 ctggtgtccg tgtggccgtc cgtcagcttc gtgagcgaga actaccgcca catgcgggat
    20821 gagcagctgc tgctgggaac ggagcacggc cagcccttcc agcatgtctt ccccgacact
    20881 caggtcggcg acaagccgct gcccgtggtg ttctacgacc ccaccgacga gcgggctcgt
    20941 gactacatct ggagccgtat caagcgcaat tactacgatc tcggcttccg gctgtggtgg
    21001 ctggacgcct gcgagccaga gatgtacccc gaacaattcg gcaacctgcg ttacgcggcg
    21061 gggccgggcc gggcggtggc caacttgtat ccgcgcgaac atgtgcgcgg gtttttcgag
    21121 catatgcggg ccgagggcga agacgttccc gtcagtctgg tgcgttccgc ctggtccggc
    21181 agtcaggcct acggggcggc tctgtggtcg ggtgacatcc cggccacctt cgaggcactc
    21241 gcggcgcagg tgtgcgccgg gctgagcgcg ggcctgagcg gcattccgtg gtggaccacc
    21301 gatatcggcg gtttccacgg tggcgacccg gacgaccctg atttccggga gttgctcatc
    21361 cgctggttcc agttcgccgt cttctgcccg ctgctgcgga tgcacggcca ccgcgaaccg
    21421 cgggacgcca tccctgccgg ccacagcggg ggccccaacg aactgtggtc ctacgggcag
    21481 gatgcctacc ggatcctgac ccggcagctg cggctacgcc aggaccttcg tgcgtacctt
    21541 caccgtcaga tggtctccgc agccgactcc ggtgcaccgg tcatccggcc gctgttcttc
    21601 gactttcccg gcgatccggc cgcgtggacg gtcgaggacc agttcctgtg cggcccggac
    21661 ctgctgatcg ccccggtgac ccgactcggt gaacgccgcc gccgggtcta cctgccggcc
    21721 ggtgccgact ggcgagccgc caccacagga actgatcatg acggcggcca gaccatcaca
    21781 gctgacgctc ccctggaatc catccccgtc ttcgtacgtc gcggctccac gctggaggtg
    21841 aggtttccgg gctgatctcc gaccggatcc gccgcggtcc ctgagtttca gcgcagcttg
    21901 ttcgattctt ttcgcgcagg cactatggga ctgtgagtaa tggcgctcgg gtgaaatgag
    21961 caagaatggc cacttccgtg ggggaaaatg gtcactctgg gtgggtgaac catgtcccca
    22021 tggccatcat cagcgtgggg ggcacggtca cagggtggag tgaaggggct cggaaactgc
    22081 tgggctatcg ccccccggag gttgtcggac accccgtcgc ggatctcctg atcaacgggg
    22141 agtaccccgc ggtgctcggg ccctgcctga gcgaagcccg ggagtggagc ggcacagcgg
    22201 ccgtccgcca ccgggatggc caccgtgtcg atctgcccct gcaccttcat ccgacattca
    22261 gtgacgacga aacaccccag gcgttcgtcg tgaccgccac cgcggatgcg ggcgaggcgg
    22321 agcccgaccg acggatggtg gagtgggcgt tcacccagtc ctccgtcgcg ctctccacct
    22381 acagcaccac gtcacgctca tggcagtgga acgcgatcgc gcacgggagt gagcagccct
    22441 cgccgaccgg gcgtatgacg ggcagcccca ctgacggcga cggggcgcag acagccgcag
    22501 ggcacgccgc agctgtcgaa tccaggcagg gacaggggca ggggcagggg caggcggctg
    22561 acgcgggcag ctggccctac tcggacctgc tgggcgcagg ccgcgccgac gagggatttt
    22621 tgcgctgcgt ccgccgggtc gccgaggagg ccaggcccag ccgctacgag cacgttgcac
    22681 cggctacgcc gaccgctcac cggcgtgcct ggaccatcga gatgtggccc gtccgcagcc
    22741 ccgacaccgg tcaggtggcc ggtgtcggcg ccgcggcgtt cgacagcacc gagcaggttg
    22801 ccgcacggca gcgcctggcc ctgctcaacg aagcgggcag ccgtatcgga accaccctga
    22861 atgtgcggcg cacggttcag gaactcgccc acctggccgt cccgcggttc gccgactccg
    22921 tcactgtgga cctgctcgac tccgtgaccc gcgggaagga accgccgccc ggtccggccg
    22981 acgccgccgt ggtgttgcgc cgggtcgcgc accagaccgc cgacggggtg cccgaagccg
    23041 acaccgagat cggcgaggcc gacacctgtc ctccgcgctc accccccgca cgtgccctga
    23101 caagcggtcg aacggtggtg tgcggagcag acgaccccga cttcgcccaa tgggtcgccg
    23161 ccggcgtggg gggatccgct cccgcggcgg agcacggatt ccactcgatc atggctaccc
    23221 cgctgcgagc gcgggacctg accctcggag tcgtggtctt cgcccgcgcg gaaggctcgc
    23281 aaccctacga gcaggatgat ctgctcgtcg ccgaggagct cgccagccgg gcggccggca
    23341 gtgtggacaa cgcgggccgt ttcgcccggg aacgcgccaa cgccctgacc ctccagcgca
    23401 gtctgctgcc ccgtcacttc ccc
//
