LOCUS       NZ_CP048852            22953 bp    DNA     circular CON 29-MAR-2024
DEFINITION  Bacillus tequilensis strain EA-CB0015 chromosome, complete genome.
ACCESSION   NZ_CP048852
VERSION     NZ_CP048852.1
KEYWORDS    RefSeq.
SOURCE      Bacillus tequilensis
  ORGANISM  Bacillus tequilensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4012371)
  AUTHORS   Cuellar-Gaviria,T.Z., Ju,K.-S. and Villegas-Escobar,V.
  TITLE     Genome sequencing, annotation and comparative genomic analysis of
            Bacillus tequilensis EA-CB0015, an effective biological control
            agent against Pseudocercospora fijiensis in banana plants
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4012371)
  AUTHORS   Cuellar-Gaviria,T.Z. and Villegas-Escobar,V.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2020) Biological Sciences, Universidad EAFIT,
            2088, Harwitch Rd, Upper Arlington, OH 43221, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-DEC-2019
            Assembly Method                   :: Unicycler v. 0.4.8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 465.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012225885.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 06:36:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,249
            CDSs (total)                      :: 4,128
            Genes (coding)                    :: 3,960
            CDSs (with protein)               :: 3,960
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 168
            CDSs (without protein)            :: 168
            Pseudo Genes (ambiguous residues) :: 0 of 168
            Pseudo Genes (frameshifted)       :: 118 of 168
            Pseudo Genes (incomplete)         :: 99 of 168
            Pseudo Genes (internal stop)      :: 51 of 168
            Pseudo Genes (multiple problems)  :: 75 of 168
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:17:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 199791
            Orig. end                         :: 222744
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP048852.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Valeska Villegas-Escobar
            Carrera 49 # 7 Sur - 50, Medellin, Colombia.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22953
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..22953
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="interleaved"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22953
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12953](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12953
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     protocluster    235..21470
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10234:11470](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10235..11470
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     misc_feature    complement(1354..1374)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.59"
                     /tool="antismash"
     misc_feature    1575..1593
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 25.12"
                     /tool="antismash"
     gene            1801..3318
                     /locus_tag="G4P54_RS01150"
                     /old_locus_tag="G4P54_01150"
     CDS             1801..3318
                     /EC_number="1.6.5.9"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388064.1"
                     /locus_tag="G4P54_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01150"
                     /product="NADH dehydrogenase subunit 5"
                     /protein_id="WP_167871513.1"
                     /transl_table=11
                     /translation="MLFSLSLSSLLTLFFIMLMISGISGLLFLVPRVPLSYVRIHIGIL
                     VLPLLVSFLLLINSNVNADIGLWHLDSIACLMTFFVLAIGFVIQRFSVRYLMGDRSYRK
                     YFTLFTFTTGAASITWLSGDLRLMVIFWGATLVGLTLLIRLNSAWHVAGEAAKVSGRLF
                     LLSWFSLFFVMIWLFQVTGQWRLSLVLINESLTQLGIWERTGIHLLIVLAVVIPAAQWP
                     FQRWLIESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLAGISVLIGA
                     GISLVQVDYKRQLVGSTIAQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQAGSVVQ
                     RHEGSTRANERSSYLWIVAGRTLALVIGVAFWLAAPGEGYQIISALILGWSLSVSWTQL
                     VAFGEGKWGRIVGLTFLGGAALVYFIIHNLFYHWLHTTVLQSVHPPMSAVIIVVCLLLF
                     GGVLSTWVVRHRSSVFSAVIYLWLLRLGEAKRKTVENHPDYLKQYLS"
     gene            3333..5948
                     /locus_tag="G4P54_RS01155"
                     /old_locus_tag="G4P54_01155"
     CDS             3333..5948
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388065.2"
                     /locus_tag="G4P54_RS01155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01155"
                     /product="YbcC family protein"
                     /protein_id="WP_167871514.1"
                     /transl_table=11
                     /translation="MGMTSVLTKENVKKKDTDIEIQGNDLNVFIQSASRVIAPLWPIST
                     FAARNPWMGLENQPFDQVAGWLKNTRDVDIYPSAAMIHSAKNKGEIDEDFLEMGLQRWL
                     DSHSFTIPQDVAERFCRAGLKLDPLPSSLLSSHKLEKLVNGCSGFDRIESFYAQPISSY
                     IENQDGERVVNILDQHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPALTKQE
                     RKRLKSWPQDAHMALQEALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQSSHEHA
                     LLTEYLAVRLSMELALTKPYLPLEKVRSEKKIPMTPLLAAWIHWGGLTLEEWSQMPASE
                     QNEYLSFAYLFDEKLRRKLWLEAWEQTYTDRLSQKIISKQRENNKKSALAQLAFCIDVR
                     SEPFRRQLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQHKIKEFADEDV
                     FQTYKQRKQAVHSVSHTFKTMKQNVLASLLLPELSGPWLSLQMAARTFVPRKTDRFIRH
                     LRDAWVRKPDTKLSLHYDGDTEAEIPVGFTDEEKVNYARQALKMMGLTKNFAPLVVICG
                     HGSQSTNNPYAAALDCGACGGAAGGFNARVLAALCNLSEVREALLTEGIAIPEDTVFAA
                     AEHDTTVDELHWLYVPELSEAAQEAFERIEAVMPKVKHHVNAERLAQLPNFQSKRKNPM
                     AEAHRYAEDWSEIRPEWGLARNASFIIGQRELTQDCDLEGRAFLHNYDWKQDESGDILA
                     NIIAGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTAGLGVMQGNASDLLTGLPWQS
                     VMKSDHEAYHSPLRLLIVIQAPREYVERLLNNNSVFLQKVQNGWVRLASIDPEGRWESW
                     "
     gene            6009..6564
                     /locus_tag="G4P54_RS01160"
                     /old_locus_tag="G4P54_01160"
                     /pseudo=""
     CDS             6009..6564
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388067.1"
                     /locus_tag="G4P54_RS01160"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01160"
                     /product="carbonic anhydrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNVNKKVLFLTDIENGLEPILQEVTDTPAENMLTIQSYGASVSHP
                     YGEIMRSVIFAIYQENVEEIFVVGTKDKRASTGNGLTQLKTMKDKIQTLDYLFQHCKPE
                     FLGGTVDEWLNENSSGGIKKSVDIIRQHPLVPSSVKVRGLIVNHKDGESSIMEVPVPAI
                     KTASSLI"
     gene            6549..6839
                     /locus_tag="G4P54_RS01165"
                     /old_locus_tag="G4P54_01165"
     CDS             6549..6839
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388068.1"
                     /locus_tag="G4P54_RS01165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01165"
                     /product="DUF6407 family protein"
                     /protein_id="WP_167871515.1"
                     /transl_table=11
                     /translation="MQSNLTDFVTKTIEEMSPFDRENMECLKKVMRKAIDYYHLKSYEE
                     VEKTDLESVRFLHIHSMMEENMLSKMIVVLRNGKTDLDIEGVYEGHVIREY"
     gene            6897..7262
                     /locus_tag="G4P54_RS01170"
                     /old_locus_tag="G4P54_01170"
     CDS             6897..7262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019257313.1"
                     /locus_tag="G4P54_RS01170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01170"
                     /product="DUF2294 domain-containing protein"
                     /protein_id="WP_167871516.1"
                     /transl_table=11
                     /translation="MKKSKGSFESEISKTITQWEKDYLGRGSVSVKTDILRDMIIVNLK
                     GVLTPAEYAVCESKEGMLSIKQTRSELVESGIEELKDIILRITGEEVTSFHTDLSSRTG
                     ERVMVFKLVNDLEKSLR"
     gene            7526..7828
                     /locus_tag="G4P54_RS01175"
                     /old_locus_tag="G4P54_01175"
     CDS             7526..7828
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097670.1"
                     /locus_tag="G4P54_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01175"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_024715632.1"
                     /transl_table=11
                     /translation="MEPIEVFKALSNESRLQILHWLKEPDRHFAPHEGIDMNTIGVCVS
                     QITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIGKLADFLKTEI"
     gene            7959..9131
                     /locus_tag="G4P54_RS01180"
                     /old_locus_tag="G4P54_01180"
     CDS             7959..9131
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388070.1"
                     /locus_tag="G4P54_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01180"
                     /product="MFS transporter"
                     /protein_id="WP_167871517.1"
                     /transl_table=11
                     /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQL
                     ITIFSLVYALSTPVLMALTASMDRRKLMMYALGLFVFGNILALILPGYGWFIAARIIMA
                     MGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIATAFGWKSVFG
                     AIALLGLIAMIVIFLTLPHTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYSVAYT
                     YLSPYLLHISGISGKLLSGVLLIFGIASLVGSKFGGYSTDKWGVPITLVGGMTLHIITL
                     ILLSLVTHSYIGVLVTLVLWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSMMQLAMA
                     VGAGIGGVFVENVSLASITWVGALGVMIAIIASLLIFYSQPKQMLKDINQ"
     gene            <9264..9585
                     /locus_tag="G4P54_RS21145"
                     /pseudo=""
     CDS             <9264..9585
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223659.1"
                     /locus_tag="G4P54_RS21145"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="FADGELKHGMIVLNKALKYSSAFAKMSKKAEQTHASS"
     misc_feature    9715..9728
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     misc_feature    complement(9716..9729)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.19"
                     /tool="antismash"
     misc_feature    complement(9717..9730)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     gene            10001..10168
                     /gene="skfA"
                     /locus_tag="G4P54_RS01190"
                     /old_locus_tag="G4P54_01190"
     CDS             10001..10168
                     /codon_start=1
                     /gene="skfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: TIGR04404"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388072.1"
                     /locus_tag="G4P54_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01190"
                     /product="sporulation killing factor"
                     /protein_id="WP_024715629.1"
                     /sec_met_domain="TIGR04404 (E-value: 6.4e-36, bitscore:
                     120.0, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNQKEWESVSKKGLIKPGGTSIVKAAGCMGCWASKSIAMTRVC
                     ALPHPAMKAI"
     aSDomain        10235..10537
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_G4P54_RS01195_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="9.80E-16"
                     /identifier="RREFam021.1"
                     /label="G4P54_RS01195"
                     /locus_tag="G4P54_RS01195"
                     /protein_end="101"
                     /protein_start="0"
                     /score="48.9"
                     /tool="antismash"
                     /translation="MSNDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIVKKEEMSAEQLKEELSAHPFTEAWTQGLLDQPLHVSGSL"
     gene            10235..11470
                     /gene="skfB"
                     /locus_tag="G4P54_RS01195"
                     /old_locus_tag="G4P54_01195"
     CDS             10235..11470
                     /codon_start=1
                     /gene="skfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008343919.1"
                     /locus_tag="G4P54_RS01195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01195"
                     /product="sporulation killing factor system radical SAM
                     maturase"
                     /protein_id="WP_024715628.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     1.4e-13, bitscore: 48.9, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 7.9e-31, bitscore:
                     105.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.5e-20, bitscore: 71.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.7e-06, bitscore: 25.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 5e-05, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIVKKEEMSAEQLKEELSAHPFTEAWTQGLLDQPLHVSGSLDSY
                     LPISCTLQLTNACNLSCSFCYASSGKPYPQELYSEQWILVMQKLAAHGVADITLTGGEA
                     KLIKGFKELVVAASSLFTNVNVFSNGLNWRDDEVELLSHLGNVSVQISIDGIDNTHDKL
                     RGRKGGFKESMNTIKKLSEANIPVIVAMTINESNAGEVSDVVEQCANAGAFIFRAGKTL
                     SVGRATEGFRGLAVDFEELVQKQLREARDRWGDRLNIIDWEHEESSFTTDFCTPGYLAW
                     YIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCDAKNCKCIGKIELSEPDLP
                     FQKEVKVGIRNE"
     gene            11463..12953
                     /locus_tag="G4P54_RS01200"
                     /old_locus_tag="G4P54_01200"
     CDS             11463..12953
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: skfc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097671.1"
                     /locus_tag="G4P54_RS01200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01200"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_167871519.1"
                     /sec_met_domain="skfc (E-value: 3.8e-277, bitscore: 918.1,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Abi (E-value: 8.2e-12, bitscore: 43.3,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLPVVFWIILAIVGLLLFIKFKPPTIASLLLSKDEAKEISVQF
                     IREFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRTVLYNIGLVEAWRVRFVHQNQ
                     SFVVGVNANREITFFYADVPKKSLSGKFEQVSPEALKQRLMVSPDGLWSRANMTGSGKK
                     EEDFHEVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQVESTF
                     GVSGMLGSAVAMIVAILILVFMDVQTSIIASLVLGLLIIMCQSLTLKEDIQLTIVNAYD
                     ARMSVKTVSILGVLSTLLTGLLTGFVVFICSLAGNALTGELGWKTFEQPMIQVFYGIGA
                     GLISLGVTSLLFNLLEKKHYVSISPELSNRTVFLSGFTFRQGLNMSIQSSAGEEVIYRL
                     LMISVIWWLSGNIIISIVISSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLGVLFIKFGF
                     ICVLAAHFIHNLVLVCMPLWQFKLQRHMHNDKPKTTSF"
     gene            12971..13693
                     /locus_tag="G4P54_RS01205"
                     /old_locus_tag="G4P54_01205"
     CDS             12971..13693
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388077.1"
                     /locus_tag="G4P54_RS01205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01205"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_167871520.1"
                     /transl_table=11
                     /translation="MQLMQVQDLSKCYRNGDGIEHLSFSIQRGEIVALLGPNGAGKTTT
                     IRCLTGLYKPDKGNILIDGSPPGHVNVQKKVALIPDQPHLYPTLTAAEHIQFRARGFHQ
                     DKKDLKERVYDALKEVHLEEKADELCGQLSRGQKQRVVLAGAIVQDALLYILDEPTVGL
                     DIPSKQWLSNWLKAKTDQGCAAFVSTHSLEFVLETADRVLLIRDGELMKSLSVPQFKEE
                     QSEWRKEVIRLLGEWSDE"
     gene            13686..15101
                     /gene="skfF"
                     /locus_tag="G4P54_RS01210"
                     /old_locus_tag="G4P54_01210"
     CDS             13686..15101
                     /codon_start=1
                     /gene="skfF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019257319.1"
                     /locus_tag="G4P54_RS01210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01210"
                     /product="sporulation killing factor system integral
                     membrane protein"
                     /protein_id="WP_167871521.1"
                     /transl_table=11
                     /translation="MNNIISFLWLQSKRRFVNQGQEKRMPFLIMLLFVGATGFQVSFVS
                     RSAIWDMSVTGWVLTGVFILYTAFGLFSNRLPSQMADIMWLYGTPTSFSKVVYSVLFFS
                     VTWKALLWIISAIFSNVVIVLLSGEHINLIGRSIIFVGLFFIAEVWLMSVSCARTVKKM
                     KRIYISVFLLMLGIYSICLFQLYFLQPSPGLWEDIGRFISGVGVVFKTLSPLYAAVFIG
                     IIAVSFMTISFTSSQVEMKESLVKEAEFWEEFQERQFGSGQIMQKTRTTWWGLQSLNGI
                     WSFLWLELLLMKKHLFFHSIHTVMMGCVFYVVIFIYPEWFNLLFFLVVSAVMLSSYYSG
                     IVRHSQSGALHLFPGALLGKIMILELTNTVWLFILYCVSIAFMGVENLVYWYIYGLGIY
                     IWFMTIRLFAFTNTNRNDFKLSLPQYYKSFFMALGLSGICLYVIHLLTAGWYTLVLVVC
                     IGSLCWCLFYRFR"
     gene            15147..15662
                     /locus_tag="G4P54_RS01215"
                     /old_locus_tag="G4P54_01215"
     CDS             15147..15662
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388079.2"
                     /locus_tag="G4P54_RS01215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01215"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_167871522.1"
                     /transl_table=11
                     /translation="MNSNGDELSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEAL
                     KEEGALRNIAAAVLGEFGEDASEAAEELSRLLKSHAEDTRMAAAISLMRIGKPSLPFVI
                     KIAQENEGESCFWASWCIAWIDPSRIEPKMYECLKHEHEHPSGMVAPFAAEEALGKLIA
                     FQLKDKGD"
     gene            15668..16093
                     /locus_tag="G4P54_RS01220"
                     /old_locus_tag="G4P54_01220"
     CDS             15668..16093
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388080.2"
                     /locus_tag="G4P54_RS01220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01220"
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_167871523.1"
                     /transl_table=11
                     /translation="MKPEQIMNEWPSHLPWLNQSQNDLIFPSDTYHLLYFWSMSCPNCH
                     QLTDKVLQDKKDMNVKVIGVHVPYIEEEKSVEVVSTYALDRGISIPIVLDQNYDIVTSC
                     HIQGIPSFCLISQYGQVVAKTMGDIGWGKMIKKVQDL"
     gene            16259..17236
                     /locus_tag="G4P54_RS01225"
                     /old_locus_tag="G4P54_01225"
     CDS             16259..17236
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388081.2"
                     /locus_tag="G4P54_RS01225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01225"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_167871524.1"
                     /sec_met_domain="PF00561 (E-value: 2.8e-06, bitscore: 25.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFGVLAALILLVSVSVFIYHHYQLNKEAALLKGKG
                     TVVDVDGKKLNVYEEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSDVSNDDRDIDTILEQTRKALMKSGNKPPYILMPHSISGIEAIYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGIDRLKVRGFHLLTSIGFHRFMPSAVYNPEVIRQSFLTDKEKEI
                     YKAINFKQFFNADMEHELLQFYQNGNKSVNLPAPKETPVLLLDAVSDQNRNSKYAIRNR
                     KDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFIRKVR"
     gene            17238..17909
                     /gene="ybdJ"
                     /locus_tag="G4P54_RS01230"
                     /old_locus_tag="G4P54_01230"
     CDS             17238..17909
                     /codon_start=1
                     /gene="ybdJ"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388082.1"
                     /locus_tag="G4P54_RS01230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01230"
                     /product="two-component system response regulator YbdJ"
                     /protein_id="WP_167871525.1"
                     /transl_table=11
                     /translation="MKSYHILIVEDDVMIGDLLQKILQREGYHVMWKTDGADVLSVIQK
                     ADLVIMDVMLPGEDGYQMSAKIKKLGLRIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRIQNMLEHHYGTFTQIKHLYIDAETKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSTLTKDHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEIIENIYGEGYRLNTVVK
                     K"
     gene            17906..18892
                     /locus_tag="G4P54_RS01235"
                     /old_locus_tag="G4P54_01235"
     CDS             17906..18892
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234894.1"
                     /locus_tag="G4P54_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01235"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_167871526.1"
                     /transl_table=11
                     /translation="MKLKTKYQLLLCTAVISVPVLLLAVSILMSVIYENMFKSMNHGTP
                     FHRSFAYPAMLVVFLLSLLLLAFLFSKSIHSLLHKINLLHHTIRHLASDQKVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELKQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     GQCHDQAVFESLYQQIGYISELTNEFNLYSAETLESSYIVNEEVRLNELLETTVKKWDY
                     LYSMNGIELHYKPADQDVIWMSNALWMQRLFDNIFQNTLKHSKAEKMEVMIEDGTVSIR
                     DDGTGFDQNENSEGLGLKIIEDVCRLLAITYELQTNENGTGFLFTKE"
     gene            18951..19213
                     /locus_tag="G4P54_RS01240"
                     /old_locus_tag="G4P54_01240"
                     /pseudo=""
     CDS             18951..19213
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097672.1"
                     /locus_tag="G4P54_RS01240"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01240"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MISICLKNSSKRSSTSQAALVTDIADTGITAAAGADITEVTAAAQ
                     AKEDTMIVMAAVIVTNVGATAAVNPKKFLFRFWDKGFFM"
     gene            complement(19198..19968)
                     /locus_tag="G4P54_RS01245"
                     /old_locus_tag="G4P54_01245"
     CDS             complement(19198..19968)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388085.1"
                     /locus_tag="G4P54_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01245"
                     /product="protein kinase"
                     /protein_id="WP_167871528.1"
                     /sec_met_domain="Pkinase (E-value: 1.6e-31, bitscore:
                     107.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKQLKKLFFDRPLKDSVILNHHYRIEECLGMGGYGLVYLCTDV
                     HTQTPYVLKQLRPTKAKKEKERVRFQQEMKLLKSIHHPQIPAFIEDFIIDGQAYYVMQL
                     IEGENIEELLFFQKQPFTELMALQLLSQLLGIVEYLHDRFIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTPEETEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTN
                     EITLLLKKLLGIDEEYQHTAFIREDLNRAIQSVT"
     misc_feature    complement(19934..19943)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            complement(20054..>20465)
                     /locus_tag="G4P54_RS01250"
                     /old_locus_tag="G4P54_01250"
                     /pseudo=""
     CDS             complement(20054..>20465)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388086.1"
                     /locus_tag="G4P54_RS01250"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="G4P54_01250"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="DKIKSGSGTFPFSGVAENKGNTALSPSGSDSSVIKVDLTNQTGIS
                     RDAIVTRVQTTATQTPSQGNACHFIMTNENNEWPPGTCH"
     gene            <20446..20577
                     /locus_tag="G4P54_RS01255"
                     /old_locus_tag="G4P54_01255"
                     /pseudo=""
     CDS             <20446..20577
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388087.1"
                     /locus_tag="G4P54_RS01255"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01255"
                     /product="DUF4885 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLETLKRQTGVNY"
     gene            20871..22259
                     /locus_tag="G4P54_RS01260"
                     /old_locus_tag="G4P54_01260"
     CDS             20871..22259
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015171 - amino acid transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388088.1"
                     /locus_tag="G4P54_RS01260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01260"
                     /product="amino acid permease"
                     /protein_id="WP_167871529.1"
                     /transl_table=11
                     /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVLL
                     AYAISGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPLAGYITAWSNWFQWIIVGMS
                     EIIAVGSYMKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTIILMI
                     IAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIGITAG
                     EAKDPQNTLRSAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKIGITAA
                     AGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFTKVSRNGVPLYGTIAVLLG
                     LAAGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKHPFKMPFA
                     PFTNYMTIAFLLMVLVGMWFNDDTRISLIVGVIFLAFVVISYYVFGIGKRSQANLAKSD
                     QAVE"
     gene            22371..22619
                     /gene="csgA"
                     /locus_tag="G4P54_RS01265"
                     /old_locus_tag="G4P54_01265"
     CDS             22371..22619
                     /codon_start=1
                     /gene="csgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388089.1"
                     /locus_tag="G4P54_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01265"
                     /product="sigma-G-dependent sporulation-specific
                     acid-soluble spore protein CsgA"
                     /protein_id="WP_167871530.1"
                     /transl_table=11
                     /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYVNEEEFVKDLDD
                     NEMSFLNHVLEKEIKYAQSEQDQKRAKELNEVYELLL"
     gene            22637..22828
                     /locus_tag="G4P54_RS01270"
                     /old_locus_tag="G4P54_01270"
     CDS             22637..22828
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388090.1"
                     /locus_tag="G4P54_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="G4P54_01270"
                     /product="DUF5370 family protein"
                     /protein_id="WP_024715608.1"
                     /transl_table=11
                     /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHYGEFVEEIEFEFNGEYP
                     DHDLIEELVNHYCFEHEI"
ORIGIN
        1 gtaacaaacg aatacgtaga gctgatggat aaagaaatgg ttatcgtcac tgacgaccaa
       61 gttgtcatca aaaaccttga tggtgacgtg attacacgtg cgtcttatat tgctgagctt
      121 gatgccagtg atatcgagaa aggcacgtac cctcactaca tgttgaaaga aacggatgag
      181 cagcctgttg ttatgcgcaa aatcatccaa acgtatcaag atgaaaacgg caagctgtcc
      241 gtgcctggag atatcgcttc tgctgtagct gaagcagacc gcatctatat catcggctgc
      301 ggaacaagct accatgcagg gcttgtcggt aaacaatata ttgaaatgtg ggcaaacgtg
      361 ccggttgaag tgcatgtagc gagtgaattc tcttacaaca tgccgcttct gtctaagaaa
      421 ccgctcttca ttttcctttc tcaaagcggg gaaacagcgg acagccgcgc ggttcttgtt
      481 caagtcaaag cgctcggact caaggcactg acaatcacaa acgtaccggg atcaacgctt
      541 tctcgtgaag ctgactacac attgctgctt catgcaggcc ctgaaatcgc tgttgcgtca
      601 acgaaagcat acactgccca aatcgcagtt cttgcggttc ttgcatctgt agccgctgac
      661 aaaaacggta ttgatatcgg atttgatctc gtcaaagaac ttggtatcgc tgcgaacgca
      721 atggaagccc tttgcgacca gaaagacgaa atggaaatga tcgcccgtga atacctgact
      781 gtatccagaa acgctttctt catcggacgc ggccttgact actttgtatg tgtcgaaggc
      841 gcactgaagc tgaaagagat ttcttacatc caggcagaag gctttgccgg cggagaactg
      901 aagcacggta caattgcctt gatcgaacaa ggcacaccag tattcgcatt ggcaacgcaa
      961 gagcacgtaa acctaagcat ccgcggaaac gtcaaggaag ttgccgctcg cggagcaaac
     1021 acatgcatca tctcactgaa aggcctggac gatgcggatg acagattcgt actgccggaa
     1081 gtaaacccag cgcttgctcc gttggtgtct gttgttccat tgcagctgat cgcttactat
     1141 gctgcgcttc atcgcggctg tgatgttgat aaaccacgta accttgcgaa gagtgttact
     1201 gtggaataaa gtgtttaacc cctttggttg tttagccaaa ggggtttttg tatacccgtc
     1261 gtttataagt gaacggatcg ttttattttg ctttctctgt attccaaagg attcccacga
     1321 actggaatat gagttttggt tgacaatgtt taaaatttag catatcttat acttaactca
     1381 ataatcggag cagatgttta tttttgctca taaaattagg actttagcat tcttttaata
     1441 tttaatttta attcttaaat cttgatagga tgaaaaagta tcctaattaa aaacgaaaag
     1501 gaacataagt cgatttattt tataattcaa ggcactaaat tgacgatatt ccattccttt
     1561 agacggaact taaaatattg tatatagtaa aatgaccaat cataaggtag cacttcaaaa
     1621 aacttcgctg aagttagttg aagtgaagcc gacaattttc aagactcaat gactaagatc
     1681 atcattgagt tttgatgttg tcggcttttt ttatttggaa aaatacgtaa ctccattcaa
     1741 agagataaat aaaattgtac taaattacag aagagaattt tacctaaggg agaatttgaa
     1801 atgttgtttt cgctgagttt gtcatcatta ttaacattat tttttattat gcttatgatt
     1861 tccgggataa gtggattatt gtttttggtt ccacgagttc ccttgagcta tgttcgcatt
     1921 catattggga ttttggtttt accgcttttg gtttcctttc tgctgcttat caatagcaat
     1981 gtgaatgcag atattggcct ttggcactta gattccatcg cttgtttaat gactttcttt
     2041 gttctcgcaa ttggattcgt cattcagcgt ttttctgtgc gttacttaat gggagatcgt
     2101 tcttatcgaa aatattttac gcttttcacg ttcactacag gtgctgcttc tattacatgg
     2161 ttaagtggcg atcttcgctt gatggttatc ttttggggag caactcttgt cggtttaacc
     2221 ttacttatca ggttgaacag tgcttggcat gtggctggtg aagcagccaa ggtttctggc
     2281 cggttatttt tgttaagctg gttttctttg tttttcgtga tgatttggct ttttcaagtc
     2341 acaggtcaat ggcggctatc attggtttta ataaatgaaa gtttaactca actggggatt
     2401 tgggagcgaa cagggataca tttattgatt gtgttagcag tggtcatacc tgctgctcaa
     2461 tggccattcc aaagatggct gattgagtct attgttgctc caactcctgt ttctgcgatt
     2521 atgcacgcag gtttagtaaa cgcaggcggg attatactca ctcgattttc acctttattt
     2581 catggtggta tcgcatcaat tattttactt ctgcttgccg gtatctctgt attgattgga
     2641 gctggtatta gtttagttca ggttgactat aaacgccagt tagtaggctc cacgattgcg
     2701 caaatgggat ttatgctcat tcagtgtgca ttaggggcct atatagcggc cattattcat
     2761 cttatattac atggtttatt caaagctacg ttgtttttac aggctggttc agtcgtacag
     2821 cgtcatgaag gatcgacgcg ggctaatgag agatcatcct atttatggat tgtggctggt
     2881 cgtacgttag ccttagtgat aggcgttgct ttttggctcg ctgctcctgg agaggggtat
     2941 caaatcatta gtgcgttgat cttagggtgg tcattgtccg tttcttggac tcagcttgta
     3001 gcttttggag aggggaaatg gggtcgaatt gttggtttaa catttttagg aggagcagcc
     3061 ctcgtctatt ttatcattca taacctcttc tatcattggc tgcatacaac cgttttacaa
     3121 agtgttcacc ctccaatgtc agctgtcatc attgttgtat gtctattgtt atttggcggt
     3181 gttctgagta cgtgggttgt tcgtcatcgt tcttccgttt tctccgcggt aatctatctt
     3241 tggttactgc gattagggga agcaaaacga aagacagtag agaatcaccc agactacctt
     3301 aaacaatatt tatcataagg agctaatctg agatgggcat gacatccgta ttaacgaaag
     3361 aaaatgtaaa aaagaaagat acagatattg agattcaagg aaatgatctt aacgttttca
     3421 ttcagtccgc cagccgagtg atcgcgccgc tctggcctat ttctacattt gctgcacgca
     3481 atccgtggat ggggcttgaa aaccaacctt ttgatcaggt tgcaggctgg ttgaaaaaca
     3541 ctcgtgatgt tgatatatac cctagtgcag ctatgatcca ttcagcaaag aataaaggtg
     3601 agattgatga agattttttg gaaatgggac tgcagcgctg gcttgattcg cattccttta
     3661 ccatcccgca ggacgtagcg gagcgatttt gccgtgctgg attaaaatta gatccgctgc
     3721 cttccagcct cttatcatcg cataagctgg agaaattggt gaatggatgt agtggatttg
     3781 atcgcatcga gagtttttat gcacaaccaa taagttcata tatagagaat caagatggtg
     3841 aaagggtagt caatatactt gatcagcatg tcattaagtg gagtaaatta tatcttgatg
     3901 actctcaagc gggttggact atgcccaatc gtgaggaagg attctatcgt gcatggcagc
     3961 atctcattca atatgatcca gcacttacta aacaggagcg taaaagatta aaaagttggc
     4021 cgcaagacgc ccatatggct ttacaagaag ctttattcgc actggaaatc ccagaatcag
     4081 aaatccagac ttatcttgaa ggccatttgc tttccttgcc tggatgggca gggatgatgc
     4141 tttggcgctc tcaacaatcg agccatgaac atgcactcct gacggaatat ttagcggttc
     4201 gactatccat ggagttggcc cttacaaagc catatttgcc tttggaaaaa gtacgatctg
     4261 agaaaaagat tccgatgact ccccttttag cagcttggat tcattggggg ggccttacac
     4321 tggaggaatg gtctcagatg ccggccagtg aacaaaacga atatttatcg tttgcttatc
     4381 tctttgatga gaaacttcgt cggaaacttt ggctagaggc ttgggagcaa acatacactg
     4441 atcgattaag tcagaagatc atctcgaagc aacgtgaaaa caataaaaaa tccgcattag
     4501 ctcaattagc attctgcatc gacgtacgat cagaaccttt tcgccgtcag ctggaaaaag
     4561 aaggtccgtt tgaaacgatt ggtattgccg gtttctttgg ggtgccgatt gcaacttgtg
     4621 aacttggcag taaacacagt catgcctcct tgccaatcat acaaaaaccg caacataaaa
     4681 taaaagagtt cgcagatgaa gatgtcttcc aaacatataa gcagcgcaag caagcagttc
     4741 attccgtaag ccatacattt aaaacgatga aacagaatgt acttgcgagc ttgcttctgc
     4801 ctgagctaag cgggccttgg cttagtctgc aaatggcagc acgcaccttt gtgccaagaa
     4861 aaacggatcg tttcattcgt catctccgtg atgcttgggt acgtaaaccc gatacaaaac
     4921 tttcacttca ttatgatggt gacacagagg cagaaatacc tgtaggtttt actgatgaag
     4981 aaaaagtgaa ctatgctcgc caagcattaa aaatgatggg attaacaaag aacttcgctc
     5041 cattagtcgt gatttgcggc catggcagtc aaagtacgaa taatccttat gccgctgctc
     5101 ttgattgtgg tgcctgcggc ggagcggccg gcggattcaa tgccagagtt ttagctgctt
     5161 tatgtaatct ttcagaggta agagaagctc ttttaactga aggaattgca atccctgagg
     5221 atacggtgtt tgcagccgct gaacatgata caacggtgga tgaattacat tggctttatg
     5281 taccagagct ttctgaagct gcacaagaag catttgaacg catcgaagct gttatgccga
     5341 aagtgaagca tcacgtaaat gcagaacgtc tggcccaatt gcctaatttc caatcgaaac
     5401 gtaaaaatcc gatggcagag gcacatcgat atgcggagga ttggagtgag atacgtccgg
     5461 aatggggact ggctcgtaat gcatctttta taatcggcca acgtgaactc actcaggatt
     5521 gtgatttaga aggaagagcc tttcttcata attatgattg gaaacaggac gaaagcggtg
     5581 atatcctggc aaatattatt gcaggtcctg gaaccgtggc ccaatggatt aatttacagt
     5641 attacgcatc aacagtagca cctcattatt atggcagcgg aaataaagcg actcaaaccg
     5701 ttactgcggg tcttggcgtt atgcagggaa atgcaagtga cttgttaacg ggactgcctt
     5761 ggcaatccgt catgaaatca gatcacgagg cttatcattc tccccttcgt ttattgatcg
     5821 ttattcaagc accgagggaa tatgtagaac ggctattaaa taacaactca gtatttctgc
     5881 aaaaagttca aaatggatgg gtccgactgg ccagtattga tccagaagga cgttgggaaa
     5941 gctggtaact attcatataa acattatccg atggattcct tactcaatat aaagaagagg
     6001 tgtgctgtat gaatgtaaat aaaaaagtat tgtttttgac ggacattgaa aacggcttgg
     6061 agcctatttt acaagaagtg actgacactc cagcggaaaa tatgctgacg atacaaagct
     6121 acggtgccag tgtctcgcat ccttatggag aaatcatgcg gtctgttatt tttgcgattt
     6181 atcaggaaaa tgttgaggag atttttgttg taggaacaaa agataagaga gcttccacag
     6241 gtaatggact aacgcaactt aaaacaatga aagataaaat acaaacattg gattatcttt
     6301 tccaacattg caagcctgag tttttaggcg gtacggtcga tgaatggtta aatgaaaaca
     6361 gcagcggcgg tattaaaaaa agcgttgata tcattcgcca acatccacta gtgccgtcat
     6421 ctgttaaagt gagagggtta atcgttaatc ataaggatgg agaatcctca attatggagg
     6481 ttcctgttcc tgctattaaa acagcgtcaa gccttatctg attattgctt gtcacctaag
     6541 gagaatgtat gcaatctaat ttaactgatt ttgtaacgaa aacaatagag gaaatgagtc
     6601 cgtttgatcg tgaaaatatg gaatgtttga aaaaagtaat gagaaaagca attgattatt
     6661 atcatttaaa atcttatgaa gaagttgaga aaaccgattt agaaagtgtg cggtttttgc
     6721 atatacactc tatgatggaa gaaaatatgt tatctaaaat gatagtcgtc ttaagaaacg
     6781 gtaaaactga tttggatatt gaaggtgtat atgaaggaca tgtgataaga gaatattaat
     6841 gagacgatat aataaataga atatgccaat ttatttgctc aggagatgtt tgatatatga
     6901 aaaagtcgaa aggttctttt gaatcagaga tcagcaagac aatcactcaa tgggaaaaag
     6961 attatcttgg gcgcgggtct gtatctgtta agaccgatat actgcgggat atgatcattg
     7021 ttaatttaaa aggagtttta acaccggctg aatatgcagt ttgtgaatca aaagagggta
     7081 tgttatctat caaacaaact cgttcggaat tagttgaatc aggtatagaa gaacttaagg
     7141 atattatcct gaggataacc ggagaagaag tgacaagttt tcatactgat ttaagctcgc
     7201 gtacaggtga acgagtgatg gtatttaaat tagttaatga tctagaaaaa tctttgagat
     7261 gaagaatgaa acaatactat tcaagccaag cagagcttga attttcatag gggctggaag
     7321 ctgattgaac atcatcatct tccgcttctt ttcattgatg actggtaaaa ggcaactaac
     7381 aaagccaacg ccgggttccc aaaagcgtac aatgacttga ttagaggcca tttttgatat
     7441 gctgtcttca gtttcatttc gtggaattag tcagaaattc aaaaaacgaa ttgacatatc
     7501 ggaatataac gatataataa tccatatgga accaattgaa gtattcaaag ccttatcaaa
     7561 tgaatcaagg ctgcaaattt tacattggct gaaggagcct gatcgtcatt ttgctcccca
     7621 tgaagggatt gatatgaaca caatcggggt atgtgtcagt caaataaccg acaaattgaa
     7681 aatgacgcaa tcgacggcat ctcaatatct taccatcctt ttaagagccg gtctgattaa
     7741 ggccgaacga atcgggaagt acacgtatta caaaagagat gaagaagcca ttgggaaact
     7801 tgctgacttt cttaaaacag agatataaaa ataaacatca attgatgttt atttttacgt
     7861 catacatatc gacatattgc gatgtgttta ttttttaaat tatatatcga catttcgtga
     7921 tatgttgttt tattaatgct gaaggagtga atgtttttat gtctaacact tggaaaattt
     7981 acattttagc cattgtcagc tttttagttg gaacctcaga gtacatcatt tccggtattt
     8041 tggatcagat cgctcataca ctggggataa ccttggctgc cgcgggccag cttattacaa
     8101 tcttttcact tgtatatgct ctttccacac ctgtacttat ggcgttgaca gcaagtatgg
     8161 atagacgcaa attgatgatg tatgccctcg gtttgtttgt gttcggcaac atcttggccc
     8221 ttatcctgcc tggttatgga tggtttattg cagcgcggat cattatggcg atgggagcgg
     8281 gtgtggttgt tgtcaccgca ttaacaattg ccgctaagat tgcatcggaa gggaagcaag
     8341 gcagtgccat cgctactgtc gtgatgggat ttaccgcttc tttaatcatt ggtgttccgc
     8401 ttggaagaat gatagcaaca gcattcggct ggaagtctgt atttggtgca attgctttat
     8461 tgggattaat cgcaatgatc gttatattct tgactcttcc gcatactgaa ggggataagc
     8521 ctgtaccctt gcttcagcag cttgctcttt tcaaaaaacg gaaagtggcg atggggttat
     8581 caatcacttt cttctggctc gggggatatt ctgttgctta tacctatctg tcgccgtatc
     8641 tcttgcacat ttccggaata agcggcaaac tgcttagcgg tgttttgctt atatttggaa
     8701 ttgccagttt ggttggatcg aagtttgggg gatatagcac agacaaatgg ggagtgccga
     8761 tcacacttgt tggcgggatg acattgcaca ttatcacatt gattctgctg tcacttgtca
     8821 ctcattccta tatcggcgtg ttggtgactc ttgtattatg gtcatttgcc gcatggtcca
     8881 ccggtccgac acagcaattc catctggcta caatagaacc ggaaatgtca ggtgtattgc
     8941 tcagcatgaa tcagtccatg atgcaacttg ccatggcagt cggcgcagga atagggggag
     9001 tttttgtaga aaacgtatca ttggcttcga ttacctgggt tggcgcgtta ggagttatga
     9061 ttgcgattat tgcatcattg ctgatttttt attcacagcc gaaacagatg ctaaaagata
     9121 ttaatcaata atacaatgct ttgttttcat ccttaacatt caatggtttt atttcgaaag
     9181 atctagcatc cgcttgtaat ataagcgggt gtttttttgt gaaattccgt caagtagaag
     9241 gtccgcagaa gccaaaagag atttttgccg acggagagct gaagcacggt atgattgtct
     9301 tgaacaaagc acttaagtat tcgtcagcat tcgcgaaaat gtcaaagaag gcggagcaaa
     9361 cacatgcatc atcttgaatg acctaaacga tgccgatgac agattcctac tgtcgaaagc
     9421 acatttagtg catcattctc gttgggttca gttgttccat tgcagctgat cgctcttact
     9481 atgtatgctg cactgcaccg cggctgtgat gttaataaat cgcgtattaa taagtttaac
     9541 tcctttggtt atttagccga aggggttttt agtatggata attgatataa attataggag
     9601 acttcattca tttaactaaa gtcattgtat ttatataatc actaaagttt tggaaaatca
     9661 tctcttgatt taatttcctt aaagaggttg tttgtcaatc taataggcat cagaattttt
     9721 atataaaaat agatcgcctt tttgaggttt tgttcataga acaacacaat attcaaaaca
     9781 taagtgaaaa ttagggtgag ctcatgtttt tctcgagagg atagcatgga agattttcta
     9841 tctttaaagg gttaatatat tctatttata tctatttaat gtaatattta ggataaaata
     9901 caaaattccc cttacttcga catttgcatt ctggtattat cgtatcgcat ggaagctatg
     9961 tctatagact ctatgcaaaa attgagagga ggttttactt atgaaaagaa accaaaaaga
    10021 atgggaatct gtgagtaaaa aaggccttat aaagccaggg ggtacttcga ttgtaaaggc
    10081 agctggctgt atgggctgtt gggcctcgaa gagtattgct atgacacgtg tttgtgcact
    10141 tccgcatcct gctatgaaag caatttaaca tttgagaata gggagttgag catatttgct
    10201 tatactcctt attttctctt gagggggatt ttatatgtcg aatgatcgtg ttaaagattt
    10261 tgatttacca gagttagcgg ttcatttaca gcctcatggt gcagtaatga ttgatagaaa
    10321 aagcatgttt tattttagac tcagcggacg tggagcacag ttggcgtttc ttttatcaaa
    10381 aaacaaaaac ctccacaaaa cggcacgtat ttgggagatt gtaaagaaag aagagatgag
    10441 tgctgaacaa ttaaaagaag agcttagtgc ccatcccttt acagaggctt ggacgcaagg
    10501 gctgttggat cagcctttac atgtttcagg ttcgttagat tcatatttac ctataagttg
    10561 taccctgcag ttgacaaatg cctgtaattt aagctgttct ttttgttatg ccagctcagg
    10621 aaaaccatat ccgcaggaac tatatagtga acaatggatt ttggttatgc aaaagctagc
    10681 agcccacgga gttgcagata ttacactgac cggaggggaa gctaagctaa taaaagggtt
    10741 taaagaatta gtcgttgctg caagttcgct atttaccaat gtaaatgtat ttagtaatgg
    10801 attgaactgg cgagacgatg aagttgaatt actcagtcac ctaggtaatg tttctgtgca
    10861 gatcagcatt gatggtattg ataatacgca tgacaaatta agaggcagaa aaggcggttt
    10921 taaagaaagt atgaatacca tcaaaaaatt atcagaagca aacatcccag tgattgttgc
    10981 tatgaccatc aatgagtcta atgccggcga ggtatctgat gtggtggagc aatgtgccaa
    11041 tgctggtgct tttatctttc gtgcaggaaa aacgttatct gtcggacgag caacagaagg
    11101 ttttaggggt ttggctgttg attttgaaga gctggttcaa aagcagctta gggaagcccg
    11161 tgaccgatgg ggagaccgcc tgaacattat tgattgggag catgaagaaa gttctttcac
    11221 aacagatttt tgtacaccag gatatcttgc ctggtacatt agagcagatg gatatgtaac
    11281 tccctgccaa ttagaggatt tgccactagg ccatatttta gaagatagca tggcagacat
    11341 tggttcacct gctcgtctgc ttcaattaaa atgtgatgct aaaaattgca aatgtattgg
    11401 gaaaatcgag ttatctgaac cggacttgcc ttttcaaaaa gaagtcaagg tagggatcag
    11461 gaatgaatag tctaccagta gtattttgga ttattttggc gattgttgga ttactgttat
    11521 ttattaaatt taaacctcca acaattgctt cactgctctt aagcaaagat gaggcaaaag
    11581 aaataagtgt gcaatttata agagaatttg ttgggattga tgtggagaac tgggattttt
    11641 actcagtata ttggtatgac catgatacag ttaataaact tcatcactta ggtatactta
    11701 agaaaaacag aacggtttta tataatattg ggttggtcga agcatggaga gtccggttcg
    11761 ttcaccaaaa tcaatcattt gtagtcggtg tcaatgccaa tcgagaaatt actttttttt
    11821 atgcggatgt tccgaaaaaa tctctctctg ggaagttcga acaagtttct ccagaggcac
    11881 tcaagcagag gttaatggtt tcgcctgatg gactttggtc tagagcaaat atgactggta
    11941 gcggtaaaaa agaagaggat tttcatgagg ttagtactta ttggtacata gcggaagcgg
    12001 gagatatccg acttaaggtg acggttgaat tacagggcgg ccgaatttca tatattggta
    12061 ctgaacaaga aatactaact gatcaaatga gtaaagtgat tcgagatgaa caagtggagt
    12121 cgacattcgg agtatctggt atgttgggct cagctgtagc gatgatagtt gcgattctca
    12181 tccttgtatt tatggatgtg caaacaagca taatcgccag ccttgtgctg ggtttgttga
    12241 ttatcatgtg ccagtctttg acactaaaag aagatatcca attgacaatt gtaaatgcct
    12301 atgatgcaag aatgagtgtc aaaacggtca gcattttagg cgttttgtcc acacttctta
    12361 caggattatt aacagggttt gtagtattta tatgttcatt ggcaggaaat gcgcttactg
    12421 gtgaattagg atggaaaacg tttgaacagc caatgattca ggttttctac ggaataggag
    12481 cggggctcat tagtttggga gtgacttcac tgctgtttaa cttattagag aaaaagcatt
    12541 atgtaagtat atctcctgag ctttctaacc gaaccgtctt tctatcaggt tttactttta
    12601 ggcaaggatt gaatatgagc atacaaagtt cggctggaga ggaggttatc tatcggctgc
    12661 taatgatttc agtcatttgg tggctgagtg gaaatatcat tatttccatt gttatatctt
    12721 cctttttgtg ggcggttatg caccaagtaa ctggatatga cccaaggtgg atacgttggc
    12781 tgcatctatt tatattcggt tgctttttgg gagttctatt tatcaaattt ggttttatat
    12841 gtgtattagc agctcatttc attcataatt tagtgctcgt ctgtatgccg ctgtggcagt
    12901 ttaaacttca gagacatatg cataacgata aaccaaagac tacttcattc taatattagg
    12961 agaagatttg atgcaattaa tgcaagtgca agatttaagc aagtgctacc ggaatggtga
    13021 tgggattgaa catttgtctt tctcaattca gcgaggagaa attgtggcgc tattaggacc
    13081 aaatggagct ggaaaaacta cgacaattcg atgtttgacg gggctttaca agccagataa
    13141 aggaaatatc ctcatcgatg gttctcctcc gggccatgta aatgttcaaa aaaaagtagc
    13201 gctcattccg gatcagcctc acctgtaccc tacattaaca gctgctgaac atattcagtt
    13261 cagggcaaga ggatttcatc aagataaaaa ggatttaaaa gaacgggttt atgatgcatt
    13321 gaaggaagta cacttggagg agaaagcaga tgaattgtgt ggtcagctgt caagaggcca
    13381 gaagcagcgg gttgtcttag cgggggcaat agttcaggat gccttgcttt atatattgga
    13441 tgagccgact gtaggtctcg atattccatc aaaacagtgg ctctcaaact ggttaaaagc
    13501 caagactgat caaggctgcg cagcatttgt gtcaactcat agtcttgagt ttgtattaga
    13561 gacagcagac agagtgttat taattcgaga tggggaactt atgaagagtt tgtctgttcc
    13621 tcaattcaaa gaggaacaat cggaatggag aaaagaagtg attcgtcttc taggggaatg
    13681 gtcagatgaa taatatcatt tcttttttat ggcttcagtc aaaaaggcgt tttgttaatc
    13741 aaggtcagga aaaaagaatg ccttttctga tcatgctcct ttttgttgga gccaccggat
    13801 ttcaagtaag ttttgtttca agatctgcaa tatgggatat gagtgttact ggttgggtgc
    13861 ttacaggtgt ttttatcctt tatacggcat ttggactttt ctccaatcga ttgccaagtc
    13921 agatggccga tatcatgtgg ctgtatggca ctccaacatc tttttcaaaa gttgtgtata
    13981 gtgttttatt tttcagtgtc acttggaagg ctttgctttg gatcatttca gccattttca
    14041 gtaatgtagt gattgttctt ctgtcgggtg agcatatcaa tttaataggc agatccataa
    14101 tttttgtagg gctctttttt atcgctgaag tatggttgat gtcagtctca tgtgccagaa
    14161 cagtgaagaa aatgaaaagg atatacattt cagtctttct tttaatgcta ggtatttact
    14221 ctatatgtct ttttcaactc tactttctac aaccttcacc tgggctgtgg gaggatattg
    14281 gtcgttttat tagtggtgta ggtgtagtgt ttaagacatt gtcaccattg tatgcggctg
    14341 tatttattgg gatcattgcg gtttctttta tgacaatttc ttttacgagc agccaggtag
    14401 aaatgaagga atcgttggtg aaggaagctg aattctggga ggagtttcaa gaacgtcaat
    14461 ttggatcagg gcaaattatg cagaaaacaa ggacaacttg gtggggacta caaagtctaa
    14521 atggtatttg gtcatttctg tggttggaac tgttgctcat gaaaaaacat ttattttttc
    14581 atagcattca taccgtcatg atgggctgcg tcttttatgt cgtcattttt atatatccag
    14641 aatggtttaa tcttctcttc tttctcgtcg tctcggcagt catgttgagt tcctattatt
    14701 caggaatagt caggcattcg caatcagggg cccttcattt attccctggt gcacttttgg
    14761 ggaaaatcat gattctagaa ctgacgaata cagtctggtt gtttattctt tactgtgtct
    14821 ctattgcttt catgggggtt gagaatttag tttattggta tatatatggc ttagggatat
    14881 atatatggtt catgacaata agactgtttg cttttaccaa tacaaaccga aatgatttta
    14941 agctttcatt gcctcaatac tacaagtcat tttttatggc gttagggctg agcggcattt
    15001 gtttgtatgt cattcattta ttgactgccg gctggtatac attagtgttg gtcgtctgta
    15061 tagggagcct ttgttggtgc ctgttttatc gtttcagata gtggattgta gaattattgc
    15121 tttttaacga ggagaggggc tcttttatga attcaaatgg tgatgaattg tcgttatctg
    15181 ttcagaattt ggcaaataca aatgagatca caattgttca agcgataggg gagctaaaga
    15241 aatcaggaaa agatgcgata cctgttttgg ttgaggcctt aaaagaggaa ggcgctttgc
    15301 ggaatatcgc tgcggctgtt ttaggcgagt ttggggaaga tgcgagtgaa gcagcggagg
    15361 agctgtcacg tttattaaaa agtcatgccg aagatactcg aatggctgca gctatttcgc
    15421 taatgagaat cgggaagccc agtctgccct ttgtcattaa aatcgctcaa gaaaatgaag
    15481 gggaatcatg cttttgggcg tcatggtgta ttgcatggat cgatccgtct cgtattgaac
    15541 cgaagatgta tgaatgcctg aaacatgagc atgaacatcc ttcagggatg gttgctccgt
    15601 ttgcggctga agaggcattg ggaaagctga ttgcttttca gctgaaagat aagggggatt
    15661 agaaaggatg aaacctgaac aaataatgaa tgaatggcca agtcatttac cctggttgaa
    15721 tcaatcacag aatgatttga tatttccaag tgacacatat catcttcttt atttttggtc
    15781 aatgagctgt ccaaactgtc accaattaac tgacaaagtc cttcaagata aaaaggatat
    15841 gaatgtgaaa gtaatcggag tacatgtccc ttatatagaa gaagagaaat ctgtggaggt
    15901 tgtctcgacg tacgctcttg ataggggaat atctattccg atagtattag accaaaacta
    15961 tgatatcgtc acaagttgtc atatacaagg tattcctagc ttttgtctaa taagtcaata
    16021 cggtcaggtc gtagctaaaa cgatgggaga tatcggttgg ggtaagatga taaaaaaggt
    16081 tcaagacttg tgaatttttc cgtcttataa gtatgtacga caaacggtta atactatgat
    16141 taaacgatcc ttcctatgag cgggaaggtt ttttaatgtc aaaataaaat ttcccaaagt
    16201 taatcagaaa tttattttca tatcgtatcc tttccgtatc acgtgaaagg agcatcatat
    16261 gaaaacatta tggaaagtcc taaagatcgt ttttggcgtt ttggctgctt tgattttgct
    16321 tgtatccgtc tcggtattta tttatcacca ctatcaatta aataaggaag cggcacttct
    16381 taaaggtaaa ggcacagtag tcgatgttga tgggaaaaag ctgaatgtgt atgaagaggg
    16441 aagcgggaag gatacgtttg tgtttatgtc cggttcgggg attgctgcgc ctgcttatga
    16501 gatgaaaggt ttgtacagca aattttcaaa agaaaataag attgctgttg ttgatcgggc
    16561 aggttatgga tacagtgatg tgtctaacga tgatagagat attgatacga tactggaaca
    16621 gacaaggaaa gcgcttatga aaagcgggaa taagcctcct tatattttaa tgcctcattc
    16681 catatccggg attgaggcga tttattgggc acagaaatat cctaaagaaa tcaaagccat
    16741 tattgcgatg gatattggct tgcctcagca gtatgtcaca tataagttga gtgggattga
    16801 cagattgaaa gtgagaggat tccatctgtt aacgtcgatt ggttttcatc gatttatgcc
    16861 ttccgctgta tataaccctg aggtgattcg tcagtcgttt ttaaccgata aagaaaaaga
    16921 aatctataaa gccattaact ttaagcaatt ttttaatgct gatatggagc atgagctttt
    16981 acagttttac caaaacggta acaaatctgt gaatctgccg gccccgaaag aaactcctgt
    17041 cttattgtta gatgcggttt ctgaccaaaa tagaaattca aagtatgcca tacgaaaccg
    17101 aaaagattat gaagcgtttg cggctcaatt caatacagcc gatataaagg aactgagggg
    17161 aacacacagt atttatttat atcagcctga tcaaatatat aaactttcca tggagtttat
    17221 tagaaaggtt cgctaggatg aagagttatc atattttaat cgtggaagac gatgtgatga
    17281 ttggtgatct gctgcagaag attttgcagc gtgagggcta tcatgtgatg tggaaaacag
    17341 atggggcgga tgtgctttca gtgattcaaa aggcggattt ggtcattatg gatgtgatgc
    17401 tgccgggtga agacgggtat caaatgtctg caaaaatcaa aaagctgggg cttcgtattc
    17461 cggtcatttt tctttcggcc cgcaatgata tggacagcaa gctccaaggg ttgcagatcg
    17521 gcgaggatta tatggtgaag ccctttgatc cgagagagct gctgttaaga atacagaata
    17581 tgcttgagca tcattatggg acctttacgc aaatcaagca cttgtatatt gatgctgaaa
    17641 ccaaaaaagt gttcaatgaa agcctgcatg atgaggtgtt gtttactgcg attgagcgga
    17701 aaattttctt ttatttatat gaaaataggg acagtaccct gacaaaggat catttctttg
    17761 aatatctgtg gcagctcgaa gacagaaacc cgaatatcgt caatgtgcac attaaaaaaa
    17821 tcagagccaa aatcaatgat caagcgggtg agattattga aaatatatat ggagaagggt
    17881 atcggctgaa taccgttgtg aagaaatgaa gttaaagaca aaatatcagt tgttattatg
    17941 tacggctgtc attagtgtgc cggtgctatt gctggcggtt agtattttga tgtctgtcat
    18001 ttatgaaaac atgtttaaat caatgaatca cggtacgcct tttcataggt cttttgcgta
    18061 tccggcgatg ctcgttgtat ttttgttatc actcttattg ttagcttttt tattttcgaa
    18121 gtcgattcat tctctgctgc ataaaatcaa tctattacat cataccattc ggcatctggc
    18181 gagtgatcaa aaggtgccgg ataaaataga ggtgaaacga gctgatgaaa tcggggagct
    18241 gattaagtct gtcaatttgt taattgaacg gacgacatat cgtgaactgg aactgaaaca
    18301 gcaggaggaa atcaaaaaag agcttttgca aaaactgcgg catgacatta atacaccttt
    18361 gaccgctctc aggctgcagt tgttttattt ggagggccaa tgtcatgatc aggccgtatt
    18421 cgaatcgctg tatcagcaaa tcggttatat ctcggaacta accaatgaat tcaatctata
    18481 ttctgctgag acgctggaaa gctcttatat tgtaaatgaa gaagtgcgtc taaacgagct
    18541 gttagaaaca acggtgaaaa agtgggatta tttatacagt atgaatggga ttgaattgca
    18601 ctataagccg gcagatcaag atgtgatatg gatgagcaac gcgttatgga tgcaaaggct
    18661 gtttgataat atttttcaaa atacgttaaa gcattcaaaa gctgaaaaga tggaagtcat
    18721 gatcgaagat ggcactgttt ctattcgcga tgatgggact ggatttgatc agaatgagaa
    18781 cagtgagggg cttgggttga agattattga ggacgtatgc aggctgcttg cgataacata
    18841 tgagctacag acaaatgaaa atggaacggg gtttttgttt acaaaagagt gaccccgctg
    18901 atgtttttct ttctcccata aactatttat aataggaaga aagaaatgag gtgatcagca
    18961 tatgtttaaa aaattcatca aaacgatcaa gcacctctca agcagctcta gtgaccgata
    19021 tcgcagacac cggcattaca gcagcagccg gcgcagacat taccgaagtt acagcagcag
    19081 ctcaggcaaa agaagacact atgatcgtta tggcggcagt catcgttaca aacgtcggag
    19141 ctacagcagc agttaatcca aaaaagttct tgttccgctt ttgggacaag ggttttttta
    19201 tgtgaccgat tgaatggcgc ggtttaggtc ttcgcgaatg aaagcggtgt gctggtactc
    19261 ttcatcaatg cctaataatt ttttcagcag cagggttatt tcatttgtga gcgttaattc
    19321 ttccagccag gtgccgtttt tcttcttttt ccctttatat tgagagtaga gcaggaacaa
    19381 cagcgtttct ccgagatcga agaaatcatc ctgttttctc acctttattt cctccgtttc
    19441 ttcaggagtc aattgctttg caaggccgaa atcgatgagg cagagcctgc cgtcattgat
    19501 gatgatatta ggcgttctga tgtcgctgtg aaatatgaag cgatcatgca ggtattcgac
    19561 gatcccgagc agctgtgaaa gcagctgtaa cgccatgagc tctgtaaacg gctgtttttg
    19621 gaaaaataat aattcttcta tattctctcc ctcaatgagc tgcatgacat aatatgcctg
    19681 tccgtctatg atgaaatctt ctataaaggc tgggatttgc gggtgatgaa tgcttttgag
    19741 cagtttcatt tcctgctgga accggactct ttctttttcc tttttggctt ttgtgggccg
    19801 cagctgtttt agcacataag gtgtttgagt atgaacatcc gtgcacaaat aaaccaagcc
    19861 atagccgccc atgccgaggc attcttcgat tctgtaatga tgatttagga taacgctgtc
    19921 ctttagaggg cggtcaaaaa ataacttttt tagctgtttt aatgccatgt ctgcacttcc
    19981 cttggttgta ctgactatag tttaccttct aagctaaaaa taaaaaagag ccggaaaacc
    20041 ggctcgatat aagttaaaac tgctttgtaa catcgtattc atagtctatt ttagctttta
    20101 cattactcat cgtcgatcta accgtcgcta atgtattata tttaaaactc catacctttg
    20161 cgacactgag ttgatctgac aatgatatat cataagaccc tgacgtcgag ctaatgacaa
    20221 gtgcccggcg gccattcgtt gttttcgttt gtcatgatga agtggcatgc atttccctgg
    20281 cttggtgttt gagtggcggt tgtttggact ctggttacaa tggcatcgcg cgatatgccg
    20341 gtttggtttg ttaaatcaac cttgatcacg ctggagtcag aacctgaggg gctaagggct
    20401 gtgtttcctt tattttcagc aacaccgctg aatgggaacg ttccgctgcc ggattttatt
    20461 ttatcaattg attacagcaa tggatctttg agagatgtgg ggcaaagcaa gagctatggc
    20521 accggagata ccgggtggct tgaaacatta aagcgccaaa ctggcgtgaa ttattaggta
    20581 agctgtccat tgagaacagc ttattttttt acaggaaata aaattttaat attctaataa
    20641 tttaactata tttatataaa agattttaat tgaagttttg gtgaaaaact ctggatatat
    20701 gtgtttacct gaaaaaaaca attgtatttt ccagagaaat ttattatgat gaaataagta
    20761 attttggaga ttatataaca attttgagtt tgaattttct gattgttgag aaggcaagct
    20821 gttctgctgt tttctcattt tcgagtatgt ggttaagagg aggaagagaa gtggcaaata
    20881 aagaattaaa gaggggcctg ggcgcgcgtc atattcagat gattgccttg ggcggtacga
    20941 tcggtgttgg cttgtttatg ggttctgcca gcaccatttc atggactggc ccgtctgtcc
    21001 ttctggcgta tgcaatatcc ggaattttta tcttttttat tatgcgtgcg atgggtgaaa
    21061 tgctttatgt cgagccgagc acaggttctt ttgcgacatt tggccatcaa tatattcacc
    21121 cgctggcagg ctatataaca gcctggagca actggttcca gtggattatc gtcggcatgt
    21181 cagaaattat cgctgtcggc tcttatatga agtattggtt cccggatttg cctgcttgga
    21241 tacctggtat cgtggcaatg gtgattcttg gtgcggcgaa tttaatttct gttaagtctt
    21301 ttggcgagtt tgaattttgg tttgcgatga ttaaaatcgt gacaattatc ttgatgatta
    21361 ttgctggaat tggaattatt ttctttggat ttggcaacgg cggggatgcg atcggcttgt
    21421 cgaatctgtg gtctcacggg ggcttctttg caggcggttt ctctggattc ttctttgcac
    21481 tgtcacttgt tattgcggcc tatcaagggg ttgagctgat cgggattaca gccggtgagg
    21541 cgaaagaccc gcaaaacacg ctaagaagtg cgattcaaag tattatctgg cgtattttga
    21601 ttttctatat tggcgctatt tttgtaatcg taacagtgta tccatgggat gagctgaact
    21661 cactcggaag tccgttcgtg tctacattct cgaaaatcgg aataacggca gcggccggca
    21721 tcattaactt tgtcgtgatt acagcggcaa tgtccggctg taacagcgga attttcagcg
    21781 cgggccgtat gctttatact ctgggtgtaa atggacaagc accgaaattc tttacgaagg
    21841 tgtcacgcaa tggggtgccg ctctatggca caatcgcggt gctgctcggt ttggctgccg
    21901 gtgttgtgct gaattatatc gcgccgccga agatttttgt atatgtatac agcgcaagcg
    21961 tgctgcctgg catgattcct tggtttatca ttttgatcag ccacatcgga ttcagaaaag
    22021 cgaagggcgc tgcattagat aaacatccat tcaaaatgcc gtttgcccct ttcacgaatt
    22081 atatgacgat tgctttctta ctgatggttc tggtcggcat gtggttcaat gatgatactc
    22141 gtatctctct gattgtaggc gtgattttct tagcgtttgt ggtcattagt tattatgtgt
    22201 tcgggattgg caagcgttcg caggccaatt tagcaaaaag cgatcaagcg gttgaataat
    22261 aggaaaagag acattcacgg atgtctcttt tttttgtttt ttggcgtatg gatttttcct
    22321 atttcagcaa gctatagggt aaagatagca aaaggaaagg tgttcataaa atggatgtta
    22381 cactcggtta tttgcgcgaa tcactttcaa accatcttga aaatgaagtt tgccagcgga
    22441 tttgcaagaa aatgctcgcg aagcggtatg tgaatgaaga ggaatttgta aaagatttag
    22501 atgacaatga aatgtctttt ttgaaccacg tcttagaaaa agaaattaag tatgcccaga
    22561 gtgaacagga tcaaaagcgg gccaaagaat taaacgaggt gtatgaatta ttgctttgag
    22621 aaaggcgggg tgagaaatgg gagcaattga acgaagcgga tatacatttc agccggagtt
    22681 tagcgtcgtc cgtcaaaacg gagccatcca tgtgtaccat tacggagagt ttgtggaaga
    22741 aatcgaattt gaatttaacg gggaatatcc cgatcacgat ttgattgaag agcttgtgaa
    22801 tcattattgt tttgagcatg agatttagag ccctgcattg cagggcttct acattaatta
    22861 ggatggatca ggtcgtctat ggtttttgtg tcggaatgcc aaacaggttc acccttatct
    22921 cgtattccgc ccgataaaga tgttcatgac agc
//
