LOCUS       NZ_JAAUXF010000001     22954 bp    DNA     linear   CON 06-NOV-2024
DEFINITION  Bacillus subtilis strain CH311 CH311_scaffold_1, whole genome
            shotgun sequence.
ACCESSION   NZ_JAAUXF010000001
VERSION     NZ_JAAUXF010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Bacillus.
REFERENCE   1  (bases 1 to 446018)
  AUTHORS   Dion,M. and Batard,E.
  TITLE     Sequencing of two strains of Bacillus subtilis to analyse their new
            metabolic properties
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 446018)
  AUTHORS   Sassi,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2020) Irs2, University of Nantes, 22 Bd Benoni
            Goullin, Nantes 44100, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2019
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 517x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_012030395.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:35:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,413
            CDSs (total)                      :: 4,340
            Genes (coding)                    :: 4,197
            CDSs (with protein)               :: 4,197
            Genes (RNA)                       :: 73
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 63
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 143
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 143
            Pseudo Genes (frameshifted)       :: 71 of 143
            Pseudo Genes (incomplete)         :: 90 of 143
            Pseudo Genes (internal stop)      :: 17 of 143
            Pseudo Genes (multiple problems)  :: 32 of 143
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:22:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 299958
            Orig. end                         :: 322912
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAAUXF010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22954
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="2"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..22954
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="interleaved"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22954
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12954](-)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12954)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     misc_feature    complement(89..103)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(549..562)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     misc_feature    complement(568..582)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.38"
                     /tool="antismash"
     gene            complement(643..1827)
                     /gene="ybdO"
                     /locus_tag="HC742_RS01440"
                     /old_locus_tag="HC742_01440"
     CDS             complement(643..1827)
                     /codon_start=1
                     /gene="ybdO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388087.1"
                     /locus_tag="HC742_RS01440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01440"
                     /product="DUF4885 domain-containing protein"
                     /protein_id="WP_086343386.1"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLMAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKTSVSGNSGAFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAAFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSTQFSEEAYKKYQ
                     AAREMYEVTGYQLKDLEVIDGRYVTPDGRDLIDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGVNY"
     protocluster    1488..22720
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[11487:12720](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(11488..12720)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     gene            1959..2816
                     /locus_tag="HC742_RS01445"
                     /old_locus_tag="HC742_01445"
     CDS             1959..2816
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388086.1"
                     /locus_tag="HC742_RS01445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01445"
                     /product="hypothetical protein"
                     /protein_id="WP_167559194.1"
                     /transl_table=11
                     /translation="MVKKWLIPFAVMLSVLSTFTYSASAVRVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEIVYVRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     VAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTS
                     ENNEWRRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     gene            2902..3672
                     /gene="pkrD"
                     /locus_tag="HC742_RS01450"
                     /old_locus_tag="HC742_01450"
     CDS             2902..3672
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pkrD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388085.1"
                     /locus_tag="HC742_RS01450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01450"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_077671182.1"
                     /sec_met_domain="Pkinase (E-value: 2.9e-33, bitscore:
                     110.1, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDI
                     LTQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKSIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTLEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT"
     gene            complement(3657..3920)
                     /locus_tag="HC742_RS01455"
                     /old_locus_tag="HC742_01455"
     CDS             complement(3657..3920)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097672.1"
                     /locus_tag="HC742_RS01455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01455"
                     /product="hypothetical protein"
                     /protein_id="WP_024571603.1"
                     /transl_table=11
                     /translation="MNSICLKKSSKRLSTSQAVLVTDIADTGITAAVGADIIAATAAVR
                     AKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD"
     gene            complement(3978..4964)
                     /gene="ybdK"
                     /locus_tag="HC742_RS01460"
                     /old_locus_tag="HC742_01460"
     CDS             complement(3978..4964)
                     /codon_start=1
                     /gene="ybdK"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234894.1"
                     /locus_tag="HC742_RS01460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01460"
                     /product="two-component system sensor histidine kinase
                     YbdK"
                     /protein_id="WP_167559195.1"
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKPADQDVIWMSNALWMQRLFDNIFQNTLKHSKAEKMEVTIEHGDVFIR
                     DDGIGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE"
     gene            complement(4961..5632)
                     /gene="ybdJ"
                     /locus_tag="HC742_RS01465"
                     /old_locus_tag="HC742_01465"
     CDS             complement(4961..5632)
                     /codon_start=1
                     /gene="ybdJ"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388082.1"
                     /locus_tag="HC742_RS01465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01465"
                     /product="two-component system response regulator YbdJ"
                     /protein_id="WP_015382624.1"
                     /transl_table=11
                     /translation="MKGYHILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKELGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     gene            complement(5634..6611)
                     /gene="ybdG"
                     /locus_tag="HC742_RS01470"
                     /old_locus_tag="HC742_01470"
     CDS             complement(5634..6611)
                     /EC_number="3.-.-.-"
                     /codon_start=1
                     /gene="ybdG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388081.2"
                     /locus_tag="HC742_RS01470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01470"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_167559196.1"
                     /sec_met_domain="PF00561 (E-value: 6.1e-08, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVCVSVFIYHHFQLNREAALLKEKG
                     TLVEVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYKAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR"
     gene            complement(6860..7285)
                     /gene="skfH"
                     /locus_tag="HC742_RS01475"
                     /old_locus_tag="HC742_01475"
     CDS             complement(6860..7285)
                     /codon_start=1
                     /gene="skfH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388080.2"
                     /locus_tag="HC742_RS01475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01475"
                     /product="sporulation killing factor biosynthesis/export
                     protein SkfH"
                     /protein_id="WP_003246390.1"
                     /transl_table=11
                     /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNCH
                     QLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVTTC
                     HVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL"
     misc_feature    complement(7252..7267)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            complement(7290..7805)
                     /gene="skfG"
                     /locus_tag="HC742_RS01480"
                     /old_locus_tag="HC742_01480"
     CDS             complement(7290..7805)
                     /codon_start=1
                     /gene="skfG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388079.2"
                     /locus_tag="HC742_RS01480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01480"
                     /product="sporulation killing factor biosynthesis/export
                     protein SkfG"
                     /protein_id="WP_003234897.1"
                     /transl_table=11
                     /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEAL
                     KEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPFVI
                     KIAQESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGKLIA
                     FQLKDKED"
     gene            complement(7852..9267)
                     /gene="skfF"
                     /locus_tag="HC742_RS01485"
                     /old_locus_tag="HC742_01485"
     CDS             complement(7852..9267)
                     /codon_start=1
                     /gene="skfF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019257319.1"
                     /locus_tag="HC742_RS01485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01485"
                     /product="sporulation killing factor system integral
                     membrane protein"
                     /protein_id="WP_167559197.1"
                     /transl_table=11
                     /translation="MNNIISFLWLQSKRRFVSQGQEKKMPFLIMLLFVGAIGFQVSFVS
                     RSTTWDMSIAGWVLTGVFILYTAFGLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFS
                     VTWKALLWIISAIFGDVLIVLLSGEHINLLGRSIIFIGLFFIAEVWLMSVSCARTVKKM
                     KRVYVSVFLLMLGIYSICLYQFFFLQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIG
                     IITVSFMTIAFTSRQVEMKESLVKEAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGI
                     WSFLWLELLLFKKYLFFHSIHTVMLSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSG
                     IVRHSQSGTLHLFPGALWKKIIILELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIY
                     IWFMTIRLFAFTHTNRNDIKLSLPQYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVC
                     IGSLSWCLFYRFR"
     gene            complement(9260..9982)
                     /gene="skfE"
                     /locus_tag="HC742_RS01490"
                     /old_locus_tag="HC742_01490"
     CDS             complement(9260..9982)
                     /codon_start=1
                     /gene="skfE"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388077.1"
                     /locus_tag="HC742_RS01490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01490"
                     /product="sporulation killing factor ABC transporter
                     ATP-binding protein SkfE"
                     /protein_id="WP_017694958.1"
                     /transl_table=11
                     /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTTT
                     IRCLTGLYKPDKGDILIEGSPPGHINVQKKVALIPDQPYLYPALTAAEHIQFRARGYHP
                     GKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPTVGL
                     DIPSKQWLSNWLKTKTDQGCSAFVSTHSLEFVLETADRVILIRDGKLMQDLYVPQFEEE
                     QAEWRKEVIRLLGEWSDE"
     gene            complement(10001..11491)
                     /gene="skfC"
                     /locus_tag="HC742_RS01495"
                     /old_locus_tag="HC742_01495"
     CDS             complement(10001..11491)
                     /codon_start=1
                     /gene="skfC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: skfc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097671.1"
                     /locus_tag="HC742_RS01495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01495"
                     /product="sporulation killing factor biosynthesis protein
                     SkfC"
                     /protein_id="WP_167559198.1"
                     /sec_met_domain="skfc (E-value: 3.4e-289, bitscore: 954.6,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Abi (E-value: 1.1e-13, bitscore: 46.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKKISIQF
                     IKEFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQNQ
                     SFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGTGKK
                     EEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQVESTF
                     GVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIICQSLTLKEDIQLTIVNAYD
                     ARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQIFYGIGA
                     GLISLGVTSLLFNLLEKKHYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIGEEVIYRL
                     LMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLGVLFIKFGF
                     ICVLVAHFIHNLVLVCMPLWQFKLQKHMHHDQPKHTSL"
     gene            complement(11488..12720)
                     /gene="skfB"
                     /locus_tag="HC742_RS01500"
                     /old_locus_tag="HC742_01500"
     CDS             complement(11488..12720)
                     /codon_start=1
                     /gene="skfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388073.2"
                     /locus_tag="HC742_RS01500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01500"
                     /product="sporulation killing factor system radical SAM
                     maturase"
                     /protein_id="WP_003234902.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2.8e-15, bitscore: 51.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 8.2e-32, bitscore:
                     105.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.9e-22, bitscore: 74.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.3e-07, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 5.4e-06, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLDSY
                     LPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEA
                     KLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQL
                     RGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTL
                     SVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCTPGYLAW
                     YIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEPDLP
                     FQKEVKAGIQE"
     aSDomain        complement(12418..12720)
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HC742_RS01500_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="1.70E-16"
                     /identifier="RREFam021.1"
                     /label="HC742_RS01500"
                     /locus_tag="HC742_RS01500"
                     /protein_end="101"
                     /protein_start="0"
                     /score="51.4"
                     /tool="antismash"
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSL"
     gene            complement(12787..12954)
                     /gene="skfA"
                     /locus_tag="HC742_RS01505"
                     /old_locus_tag="HC742_01505"
     CDS             complement(12787..12954)
                     /codon_start=1
                     /gene="skfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: TIGR04404"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388072.1"
                     /locus_tag="HC742_RS01505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01505"
                     /product="sporulation killing factor"
                     /protein_id="WP_009966416.1"
                     /sec_met_domain="TIGR04404 (E-value: 4.8e-38, bitscore:
                     123.7, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVC
                     ALPHPAMRAI"
     gene            complement(13426..>13794)
                     /locus_tag="HC742_RS21970"
                     /pseudo=""
     CDS             complement(13426..>13794)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388059.1"
                     /locus_tag="HC742_RS21970"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="glutamine--fructose-6-phosphate aminotransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KGRHRSVCVEGALKLKGIS"
     gene            complement(13877..15049)
                     /gene="ybcL"
                     /locus_tag="HC742_RS01510"
                     /old_locus_tag="HC742_01510"
     CDS             complement(13877..15049)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybcL"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388070.1"
                     /locus_tag="HC742_RS01510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01510"
                     /product="MFS transporter"
                     /protein_id="WP_021481923.1"
                     /transl_table=11
                     /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQL
                     ITIFSLVYALSTPVLMALTASMDRRKLMMYALGLFVFGNVLAFVLPGYGWFIAARIIMA
                     MGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIAVALGWKSVFG
                     AIALLGLIAMVVIFFTLPHTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYSVAYT
                     YLSPYLLNISGINGKLLSGVLLIFGIASLVGSKFGGYSTDKWGVSFTLVGGMTLHIVTL
                     ILLSLVTHSYIGVLVILILWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSMMQFAMA
                     VGAGIGGVFVENVSLASITWVGALGVMIAIIASLLIFNSQPKQALKDINQ"
     gene            complement(15176..15478)
                     /gene="ybzH"
                     /locus_tag="HC742_RS01515"
                     /old_locus_tag="HC742_01515"
     CDS             complement(15176..15478)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ybzH"
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097670.1"
                     /locus_tag="HC742_RS01515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01515"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_167559199.1"
                     /transl_table=11
                     /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFVPHEGIDMNTIGVCVS
                     QITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIGKLADFLKTEI"
     gene            complement(15960..16334)
                     /gene="ybcI"
                     /locus_tag="HC742_RS01520"
                     /old_locus_tag="HC742_01520"
     CDS             complement(15960..16334)
                     /codon_start=1
                     /gene="ybcI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388069.1"
                     /locus_tag="HC742_RS01520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01520"
                     /product="DUF2294 domain-containing protein"
                     /protein_id="WP_003246482.1"
                     /transl_table=11
                     /translation="MKKSKGSIESEISKSITQWEKDYLGRGSVSVKTDILRDMIIVNLK
                     GILTPAEYVVCGSKEGMLSIKQTRSELVESGIEGLKDIILKITGEKVKSFHTDLSSRTG
                     ERVMVFKLCNDLEKNLEKIL"
     gene            complement(16392..16682)
                     /gene="ybcH"
                     /locus_tag="HC742_RS01525"
                     /old_locus_tag="HC742_01525"
     CDS             complement(16392..16682)
                     /codon_start=1
                     /gene="ybcH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388068.1"
                     /locus_tag="HC742_RS01525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01525"
                     /product="DUF6407 family protein"
                     /protein_id="WP_015252954.1"
                     /transl_table=11
                     /translation="MSANLTDFVTKTIEDMNSFDRENMECMKKLIRKAIDFYHLKSYEE
                     VEETHSGNVRFLHVHSMMEENMLSKMIVVTRNGKTDLDIEGVYEGYVVREY"
     misc_feature    complement(16728..16742)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.3"
                     /tool="antismash"
     gene            complement(16743..17270)
                     /gene="ybcF"
                     /locus_tag="HC742_RS01530"
                     /old_locus_tag="HC742_01530"
     CDS             complement(16743..17270)
                     /codon_start=1
                     /gene="ybcF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388067.1"
                     /locus_tag="HC742_RS01530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01530"
                     /product="carbonic anhydrase"
                     /protein_id="WP_153255598.1"
                     /transl_table=11
                     /translation="MNVNQNKKVLFLTDIENGLEPILQEATNTSAENMLTIQSYGAGIS
                     HPYGEIMRSVIFAIYQEDVEEIFVVGTKDKKTSAGNELTQLETMKDKIQTLDYLFQNCK
                     PEFFGGTVDEWLNENSSDTIEKSVDMIRHHPLVPSYVKVRGLFVNHKDGKPSIMEGPDA
                     KTGQAIPDHCLS"
     gene            complement(17347..19962)
                     /gene="mpsB"
                     /locus_tag="HC742_RS01535"
                     /old_locus_tag="HC742_01535"
     CDS             complement(17347..19962)
                     /codon_start=1
                     /gene="mpsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388065.2"
                     /locus_tag="HC742_RS01535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01535"
                     /product="DUF2309 domain-containing protein"
                     /protein_id="WP_167559200.1"
                     /transl_table=11
                     /translation="MGITSVLTKDNVKKIDTDIDVQERDLNVFITSASRVIAPLWPIST
                     FAARNPWMGLENQSFDQVASWLKNTRDVDIYPSASMIRSAKNKGEIDEDFVEMGLQRWL
                     DSHSYHIPRDVAERFCHAALKLDPLPSDLLSSHELEKLVGECSGLDHIENVFMQPLSSY
                     IENQDGERLVNILDHHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPALSKKQ
                     RERVKDWPKEAHLALQEALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQSSHEHA
                     LLTEYLAVRISMEWALIKPYLPLTNERSKKTISIAPLIAAWIHWGGLTLEEWSQMTAIE
                     QNEYLSFAYSFDEKLRKKLWLEAWEQTYTDRLSQKIISKQRETGGKKSALAQLAFCIDV
                     RSEPFRRQLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQNKIKEFADED
                     VFKKYNQRKQAIHSLSHTFKTMKQNALSSLLLPELSGPWLTLQMAARSFVPRKAGRFIR
                     NLREAWLRKPDTKLSLHHDTTEAEIPVGFTDEEKVNYARQALKMMGLTENIAPLVVICG
                     HGSQSTNNPYSAALDCGACGGAAGGFNARVLAALCNLSEVREALLTEGIKIPEDTVFAA
                     AEHNTTVDELHWLYVPELSEAAQEAFEQIEAVMPKVRHHVNAERLAQLPNFQSKLKNPK
                     AEANRFAEDWSEIRPEWGLARNAAFIIGKRELTQDCDLEGRAFLHNYDWKQDESGELLA
                     NIIAGPGTVAQWINLQYYASTVAPYYYGSGNKATQTVTAGLGVMQGNASDLLAGLPWQS
                     VMESDHEAYHSPLRLLILIQAPREYVERLLNHDSAFLQKVQNGWVRLASLDPEGCWESW
                     "
     gene            complement(19977..21494)
                     /gene="mpsA"
                     /locus_tag="HC742_RS01540"
                     /old_locus_tag="HC742_01540"
     CDS             complement(19977..21494)
                     /EC_number="1.6.5.9"
                     /codon_start=1
                     /gene="mpsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388064.1"
                     /locus_tag="HC742_RS01540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01540"
                     /product="NADH dehydrogenase subunit 5"
                     /protein_id="WP_101169890.1"
                     /transl_table=11
                     /translation="MLVSLSLSSLLTLFFIMLMASGISGLLFLHPRVPLSFVRIHIGIL
                     ALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSYRK
                     YFTLFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKVSGRLF
                     LLSWFSLFFAMMWLFHATGQWQLSLVVTNESLAGLGEWERTGIQLLIVLAVIIPAAQWP
                     FQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLAGISVLIGT
                     GISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQAGSAVG
                     RHEVSARTNERTSYLWVMAGRILSLVIGVAFWLAAPGEGYQFISALILGWSLSVSWTQL
                     VAFGEGRIGRIAGLTVLGGAALVYFIIHNLFYKWLHTTIFQSVQPPMSAVMIVVCLLLF
                     GSALGTWVARHRSSVFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS"
     gene            complement(22013..22555)
                     /gene="adaB"
                     /locus_tag="HC742_RS01545"
                     /old_locus_tag="HC742_01545"
     CDS             complement(22013..22555)
                     /codon_start=1
                     /gene="adaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388063.1"
                     /locus_tag="HC742_RS01545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HC742_01545"
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="WP_130573430.1"
                     /transl_table=11
                     /translation="METKNKPTLYWSLLMFKDWNFYIASTLKGLVFVGSQNKPIEELFE
                     WARKRFPGSLLVEDDDKLEPYAVEITQYLEGKRKNFTVPVEYAGTQFQLAVWNALCEIP
                     YGQTKSYSDIANEINKPAAVRAVGAAIGANPVLITVPCHRVIGKNGSLTGYRGGFEMKT
                     LLLDLEKRASSEMDVPH"
ORIGIN
        1 cagcgataat ttctgacatg ccgacgataa tccactggaa ccagttgctc catgctgtta
       61 tataacctgc catcggatga atatattgat ggccgaacgt cgcaaaagaa cctgtgctcg
      121 gctcgacata cagcatttca cccatcgcac gcataataaa aaagataaaa attccgcata
      181 ttgcataagc cagaaggaca gatggaccag tccatgaaat cgtgctggca gaacccataa
      241 acaagccaac accgattgta ccgcccaagg cgatcatctg aatatggcgc gcgcccaggc
      301 ccctctttaa ttctttattt gccactcctc ttcctcctcc taacaaaata ctcataaatg
      361 agaaaacagc agacctgctt gccttcacat gaatcagtga taacaatcag aaaattcaaa
      421 cttaaaattg ttatataatc tcctaaatta cttatttcat cataataaat ttctccggaa
      481 aatacaattg tttttttcag gtaaacacct ttgttcagag ttttgaatcg ttcacttctt
      541 ttaaaatctt ttatataaaa ataataaaat tgtttgaata ttaaaattaa tacacccctt
      601 agattctcat aaaaaataag ctgttctaca tgaacagctt acttaataat tcacacccgt
      661 ttgacgcttt aatgcttcaa gccacccggt atctccggtc ccatagctct tgctttgtcc
      721 cacatctctc agagatccat tgctgtaatc aattgatagg atgaaatccg gaatggcatt
      781 atacccggct tccgcgattt tactgagctc tgaacgatag taagatatag cataagaagc
      841 cgtttgcttc tgcactggat ctttttcaag ctcttcctta tatacatcta ttaagtcacg
      901 tccatcaggc gtgacgtacc gtccatcaat gacttctaaa tccttcaatt gataacctgt
      961 gacttcgtac atctcacgag ctgcctgata ctttttatag gcctcttcgg aaaattgtgt
     1021 tgaatcactg ctttgacttt tcatgatgtg taaaaatagt tctttgctgt tgtctccaga
     1081 ttgcagcact tgctcaattt gcttgatcag atcctgatcg tctgtcccgc tcacccgcac
     1141 ctgatagtca atcggtgtga ttgtaaacgt cagctctgtc ccctctggaa tatgaatatg
     1201 gtttcgattc aacagcactt gcagctgctg gttaacctgt ccccgctgat acaccttttc
     1261 attctcagct tccacttccc catgaaatgt gacattccga aacgcagcat cctggaggtt
     1321 atagttttgc gccttccctt tgaatagcca ttctgtttca ttatcgtaag cggcctgtct
     1381 ttctgcagct gacagatcac ttctgaaata aggagacttt gaattttggt acttatcctt
     1441 aatatagcct aatggatcag actttgtttt attaatcgca ttcatcctgc tgtatttttc
     1501 atctagtatt ttgattctga tatcactctc agattcatag gggttttggg attgaatcac
     1561 tgtttcttcc cctgtgtctg tcactgttcg atcattcgct gattgataca ctttgctgaa
     1621 cgccccgctg tttcccgaca cgctggtttt agaataattg aactgattga ttcccccagt
     1681 tgaagattgt gacttaagcc tgctgtatgc cttttccaga actgccgctg gattttcagt
     1741 cgcattctcc cgtttggcag gcgcattctt gctcaatatg ttctgtgcca tcagctgagt
     1801 gcggataaat tgccgattca gacgcattga attccctccc gagtattctc tcttattctt
     1861 ttttatcggc aaagataatg tatatattaa ccttgaaaaa catttattta cacctaaatc
     1921 gttattatgt atgatggaaa taaaaggagg ttgtttgcat ggtgaaaaaa tggcttattc
     1981 cattcgctgt tatgctgtct gtcttatcca cctttacgta ttcggcatca gctgtcagag
     2041 tcactgctat cacaggaaac aattcatttg ataccgcaat gccgatcggt tattggaaat
     2101 ataaaaatat cgatacaaca atactggaag ctggtcaaga tgaagcctat ttcactttta
     2161 cggctaataa gggagaaata gtatacgtga ggagtacata ccagagcgcg tatacaggga
     2221 tgaaaattga aatttatgac aagaacagaa tacctgtttc tcaagggaca gaagttatta
     2281 accctaatac gttttcttct tttatttatg caaatgcaga cgcccaaaac acgacagata
     2341 ccttttatgt gaaagtgtca cgaggcacct ataccggaaa catgtatttt acactttcaa
     2401 ttgaagaccg aatcaaatcg ggcagcggaa cattccaatt cagcggcgtt gctgaaaata
     2461 aaggaaatac aagccttagc ccctcaggtt ctgactccag cgtgatcaag gttgatttaa
     2521 caaaccaatc tgggataccg cgtgatgcca ttgtaaccag agttcagaca accgccactc
     2581 aaacaccaag ccagggaaat acacgccacc tgatcatgac gagcgaaaac aacgaatggc
     2641 gccgtgctct tgtaaacagc tcgacttcag ggtcttatga tatctctttg tcagatcaac
     2701 tcagtgtggc aaaggtatgg agttttaaat ataatacatt agcgacagcc agatcgacga
     2761 tgagcaacgt aaaagcaaaa atagattatg aatacgacgt gacaaagcag ttttaactta
     2821 taccgagccg gttatccggc tcttttttat tctcagtcta gaaggtaaac tatagtcagt
     2881 acaaccaagg gaagtgcaga catggcatta aaacttctaa aaaaactgct atttgaccgc
     2941 cctctaaaga acggcgttat cttaaatcat caatacaaaa tcgaagagtg cctcggtatg
     3001 ggaggctacg gtttggttta tttgtgcacc gatatcctaa ctcaaacacc ttatgtctta
     3061 aaacagcttc ggccgacaaa agcgaaaaag gaaaaagaaa aagtccggtt ccagcaggaa
     3121 ataaaactgc tcaaaagcat tcaccacccg caaattccgg gcttcataga tgagttcatc
     3181 atagacggac aggcttatta tgtcatgcag ttcattgagg gagagaatat agaagaatta
     3241 ttattttttc gaaaacagcc gttcacagag cttatggcgt tacaactgat ttcgcagctg
     3301 cttgagatta tagaatacct gcatgatcgc cttattttcc acagcgacat cagaacgcct
     3361 aatatcatca tcaatgacgg caggctctgc ctcatcgatt tcggccttgc caaacaattg
     3421 actcttgaag aaatggagga aataaaggta cgaaaacagg atgacttctt cgatctcgga
     3481 gaaacgctgt tattcctgct gtactctcaa tataaaggaa aaaagaagaa aaatggcact
     3541 tggctggagg aattaacact gacaaaggaa gtaaccttgc tgctgaaaag attattgggc
     3601 attgaggaag agtatcagca caccgcttcc attcgcgagg atctaaaccg ggccattcaa
     3661 tcggtcacat aaaaaaaccc ttgtcccaaa agcggaacaa gaactttttt tggattaact
     3721 gctgctgtag ctccggcgtt tgtaacgatg actgccgcca taacggtcgt agtgtcttct
     3781 tttgcccgaa ctgctgctgt agctgcgata atgtctgcgc cgactgctgc tgtaatgccg
     3841 gtgtctgcga tatcggtcac tagaactgct tgagaggtac ttaatcgttt tgatgatttt
     3901 tttaaacata tgctgttcac cccatttctt tctcctatta tataaatttt ataggagaaa
     3961 gaaaaacatc agcggggtca ctcttttgaa aacaagaacc ccgttccgtt atcatttgta
     4021 tgcagctcat aagtaatcgc aagcagcctg catgtatcct caataatctt taacccaagt
     4081 ccctcactgc tctcattccg atcaaatcca ataccgtcat cacgaataaa aacatcgcca
     4141 tgttcaatcg tgacttccat cttttcagct tttgaatgct ttaacgtatt ttgaaaaata
     4201 ttatcaaaca gcctttgcat ccataacgcg ttgctcatcc atatcacatc ttgatctgcc
     4261 ggcttatagt gcagctcaat cccactcata ctgtataaat aatcccactt tttcaccgct
     4321 gtttctaata gctcgtttag acgcacttct tcatttacaa tataagagct ttccagcgtc
     4381 tcagcggaat atagattgaa ttcattggtt aattccgaga tatattcgat ttgctgatac
     4441 aatgattcga atacagcctg accatgacat tggtcttcca aataaaataa ctgcagcctg
     4501 agagccgtta aaggtgtatt aatgtcatgc cgcagttttt gcaaaagctc ctttttgatt
     4561 tcctcttgct gtctcagctc cagttcacga tatgtcgtcc gttcaattaa caaattgacc
     4621 gacttgatca gttccccgat ttcatccgca cgcttcactt caattttatc gggcaccctt
     4681 tgatcactcg ccaaatgccg aatggtttga tttaatagat tgattttatg caacagagaa
     4741 tgaatcgact ttgaaaataa aaaagctaac aataagagcg atatcaaaaa tacaacgatc
     4801 attgccgggt acgcaaacga cctgtgaaag ggcataccat gattcatcgg tttaaacatg
     4861 ctgtcataaa tcacagacat caaaacactg accgccagca atagcatcgg aacactaatg
     4921 acggccgtaa acaataacaa ctgatatttt gtcttgagct tcatttcttc acaacggtat
     4981 tcagccgata cccttctcca tatatatttt caatcatctc acccgcttga tcattgattt
     5041 tagctctgat ttttttaata tgcacattga caatattcgg gtttctatct tcgagctgcc
     5101 atagatattc aaagaaatgt tcctttgtca ggatactgtc tctattttca tataaataaa
     5161 agaaaatttt ccgctcaatc gcagtaaata atacctcatc atgcaggctt tcattgaaca
     5221 cttttttcgt tactgcatca atatacaaat gtttgatttg cgtaaaggtg ccataatgat
     5281 gctcaagcat attccgcatt cttaatagca gctctctcgg atcaaagggc tttaccatat
     5341 aatcctcgcc gatctgcaaa ccttgaagtt tgctgtccat gtcattacgg gccgaaagaa
     5401 aaataaccgg aatgcccagc cccagctctt tgatttttgc agacatttga tacccgtctt
     5461 cacccggcag catcacatcc ataatgacca aatccacctt ctgaatcacc gaaagcacat
     5521 ccgctccatc tgttttccat atcacacgat atccctcacg ctgcaaaatc ttttgcagca
     5581 aatcaccaat catcacatcg tcttcaacga ttaaaatatg ataacccttc atcctagcga
     5641 acctttctca taaactccat ggacagttta tatatttgat caggctgata taaataaata
     5701 ctgtgtgttc ccctcagttc ctttatatcg gcagtattga attgagccgc aaacgcttta
     5761 tagtcttttc tgttttgtat agcatacttt gaatgtctat tttggtcaga gaccgcatct
     5821 aaaatcaaga cgggagtttc ctttggcgcc ggcagattca cagatttgct gccgttttgg
     5881 taagactgca aaagctcatg ctccatatct gcattaaaaa attgcttaaa gttaatggct
     5941 ttatagattt ctttttcttc atcagttaaa aacgactgcc gaatcacctc aggattatat
     6001 acagcggaag gtataaaccg atgaaaacca atcgaggtta acaggtggaa ccctctcact
     6061 ttcaatcggt caactccgct caatttatac gtgacgtact gctggggcaa tccaatatcc
     6121 atcgcaataa tggccttgat ttccttagga tatttctgtg cccaatacat cgcttcaatc
     6181 ccggatatcg aatgaggcat taaaatataa ggaggcttat ttccgctttt cataagcgct
     6241 ttcctcgtct gttccaatac cgtatcaata tctctgtcat cgtgagacac ttcactgtat
     6301 ccataacctg cccgatctac aacagcaatc ttattttctt ttgaaaactt gctgtacagc
     6361 cccttcattt cataagcagg cgcagcaatc cccgaaccgg acataaacac aaacgtatcc
     6421 ttcccgcttc cctcttgata cacattcatc tttttaccat caacttcgac taatgtgcct
     6481 ttttctttaa ggagtgccgc ctccctattt agctggaaat ggtgataaat aaataccgag
     6541 acgcatacaa gcaaaaccaa agcagccaag ctgacaaaaa caattttgag gactttccat
     6601 aatgttttca tatgatgctc ctttcacttg atactgaaag gatacaatat gaaaataaat
     6661 ttctgattaa ctttggaaca gttttatttt cacatttaac tttgccctta cggaaaggtg
     6721 tacatttgga gcatagcaga acatttggtg aatttaccta ctaataaaaa aatatttcat
     6781 aaaaaaacct tcctgcttat aggaaggacc gtttcatcat aatattcaac cgtttgtcgc
     6841 acatacaaga cggaaaattt cacaagcctg caatcttttt taacatctta tcccaaccaa
     6901 catctcccat cgttttagta atgatctgac cgtattgact taatagacaa aagctgggga
     6961 tgccttgtac gtgacaagtt gtgacgatct catagttttg gtctaataca atcggaatag
     7021 ctagtcccct atcaagagca tacgtcaaga caacctccat agatttctct tcttctatat
     7081 aagggacatg tactccgatt actttcacat tcatatcctt tatatcttga aggactttgt
     7141 ctgttaattg gtgacagttt ggacagctca ttgaccaaaa ataaagaaga agatatgtgt
     7201 cacttggaaa tgtaaaatca ttctgtgatt gattcaacca tggtaaatga cttggccatt
     7261 cagtcaacat ttgttcatct ttcatccttt cagtcctcct tatctttcag ctgaaaagca
     7321 atcagctttc ctaatgcctc ttcagccgca aacggagcaa ctattcctga aggatgttca
     7381 tgctcgtatt ttagacattt atacatctta ggttcaatgc aagacggatc aatccatgca
     7441 atacaccaag atgcccaaaa gcacgattgc ccttcacttt cttgagcgat tttgatgaca
     7501 aagggcagac tgggcttccc gattctcatt aatgaaatcg ccgctgccat tcttgtatct
     7561 tcggcatgac tttttaataa acatgatagc tcctccgctg cttcactcgc gtcttcccca
     7621 aactcaccta aaacagctgc agcaatatta cacaaagagc cttcctcttt taaggcctca
     7681 accaaaactg gtattgcatc ttttcccgat ttctttagct cacctatcgc ttgaacaatt
     7741 gtgatctcat ttgtattcgc taaattctga acagataacg acaatttatc accatttgaa
     7801 ttcataaaag agcccctctc ctcgttttaa aacaataact ctacataacc actatctgaa
     7861 acgataaaac aggcaccaac ttaggctccc tatacagacg accaccacta atgtatacca
     7921 gtcagcagtc aataaatgaa tgacatacaa acaaatgccg ctcaggccta atgccataaa
     7981 aaatgacttg taatattgag gcaatgaaag cttaatatcg tttcggtttg tatgggtaaa
     8041 agcaaaaagc cttattgtca tgaaccatat atatatccct aagccatata tataccaata
     8101 aactaaattc ccaactgcca taaaagtaat agagacacag taaagaatat acaaccagac
     8161 tgtattcgtc agctctagaa taatgatttt tttccaaagg gcaccgggga ataaatgaag
     8221 ggtgcctgat tgagaatgtc tgacaattcc tgaataatag gaacttaaca tgactgccga
     8281 gacgataaga aagaaaagaa gataaaacca ttctggatac atgaaaatga cgacataaaa
     8341 gacgccactg agcatgaccg tatgaatgct atgaaaaaat aaatattttt taaaaagcaa
     8401 cagttccaac cacagaaaag accaaatgcc atttagacct tgcaagcccc accaagtcgt
     8461 ttttggtttc tgtataattt gacctgaacc aaattgacgt tcttgaaatt cctcccagaa
     8521 ttcagcttct ttcaccaacg attccttcat ttctacctga cggctcgtaa aagcaattgt
     8581 cataaaagag actgtgatga tcccaataaa tacaaccaca tacaacggtg acaatgtatc
     8641 aaacactaat ccaacgccac taataaaacg ggcaatgctc tcccatatcc cagatgaatg
     8701 ttggagaaag aagaattgat aaagacatat ggagtaaatg cctaacatta gaagaaagac
     8761 tgaaacgtat acccttttca ttttcttcac tgttctggca caggagaccg acatcaacca
     8821 cacttcagcg ataaaaaaga gccctataaa aattatggat cggcctaata aattgatatg
     8881 ctcaccagac agaagcacaa ttaatacatc accgaatatg gctgagatga tccaaagcaa
     8941 cgccttccaa gtgacgctga aaaataaaac actatacaca acttttgaaa aagatgtggc
     9001 agtgccataa agccatataa tatctgccat ttgacttggt aatcgatttg aaaaaagtcc
     9061 aaatgccgta taaaggataa aaacacctgt aagtacccaa ccagcaatac tcatatccca
     9121 tgtcgtagat ctagaaacaa aacttacttg aaatccgatg gccccaacaa aaaggagcat
     9181 gatcaaaaaa ggcatttttt tttcctgacc ttgactgaca aaacgccttt ttgactgaag
     9241 ccataaaaaa gaaatgatat tattcatctg accattcccc cagaagacgt atcacttctt
     9301 ttctccattc cgcttgttct tcttcgaatt gaggaacata caaatcctgc atgagtttgc
     9361 cgtctctaat taatatcacc ctgtctgctg tctctaaaac aaactctaga ctatgagttg
     9421 atacaaatgc tgaacaccct tgatcggttt tagtttttaa ccagttagag agccactgtt
     9481 ttgatgggat atcaaggccc acagtcggtt cgtctaatat atacagcaaa gcgtcttgaa
     9541 caatcgcccc cgccaggaca acccgctgct tttggcctct tgacagctga ccacacaatt
     9601 ggtttgcttt ctcctccaag tgcacttcct tcaatgcatg ataaaccctt tcttttacat
     9661 cttttttacc tggatgatat cctcttgccc taaactgaat atgttcagca gcggttaaag
     9721 cgggatacag atatggctga tcaggaataa gcgcgacttt tttttgaaca tttatatgtc
     9781 ctggaggaga accctcaatg aggatatctc ctttatccgg cttatagaga cctgtcaaac
     9841 atcgaattgt cgttgttttt ccagctccat ttggccccaa tagcgccacg atttctcctc
     9901 gttgaattga gaaagacaaa tgttcaaccc catcaccatt tcgatagcat ttgcttaaat
     9961 tttgtacttg catcaattgc atcaaatctt ctcctaatca ttagagtgaa gtatgctttg
    10021 gctgatcatg atgcatatgt ttctgaagct tgaactgcca cagcggcata cagacgagta
    10081 ctaaattatg aatgaaatga gctactaata cacaaataaa accaaatttg atgaagagaa
    10141 ctcccagaaa gcaaccgaat ataaatagat gcagccaacg tatccacctt gggtcatatc
    10201 cagttacttg gtgcatcacc gcccataaaa aggaagatac aataatggag atgaggatat
    10261 ttccactcat ccaccaaatg actggaatca ttaatagccg atagatgacc tcttctccaa
    10321 ttgaactttg tatgctcata ttcaatcctt gcctaaaggt aaaacctgat agaaagacag
    10381 ttcggttaga aagctcaggt gaaattcgta aataatgctt tttctccaat aagttaaaca
    10441 gcagagaagt cactcctaaa ctaatgagcc ctgctcctat tccatagaaa atctgaacta
    10501 ttggttgttc aaacgttttc catccaaaat caccagcaag cgcatttcct gccaatgaac
    10561 atataaatac tacaaatcct gttaataatc ctgtaagaag tgtagacaaa atacctaata
    10621 aactgaccgt tttgacactc attcttgcat cataagcatt tacaattgtt aattgaatat
    10681 cttctttcag cgtcaatgac tggcatatta taatcaacaa acccagaaca agactgaaga
    10741 ttatgcttgt ttgcacatcc ataaatacaa ggatgagaat cgcaaggatc atcgctaaag
    10801 ctgaacccag cataccagat actccgaatg tcgattccac ttgttcatct cgaatgactt
    10861 tactcatttg atctgttagt atttcttgtt cagtaccaat ataagaaatt cggccgccct
    10921 gtaattcaac agtcaccttg agccgaatat ctcccgcttc cgctatgtac caataagtac
    10981 tgacctcgcg aaaatcctcc tcttttttac cagtaccagt catatttgct ctagaccaaa
    11041 gtccatcagg tgaagccatt aacctctgct tgagtgtctc tggagaaact tgttcaaact
    11101 tccccgaaag agtttttttc ggaacatccg cataaaaaaa agtgatttct cgattggcat
    11161 tgacaccaac tacaaatgat tgattctggt gaacgaaacg gactctccat gattcgacca
    11221 acccaacatc atataaaacc tttctatttt tcttaagtat gcctaagtga tgaagtttat
    11281 tcactgtatc gtggtcatac caatataccg aataaaaatc ccagttctct acatctatcc
    11341 caacaaactc ttttataaat tgaatgctta ttttttttgc ctcatctttg cttaagagta
    11401 gtgaagcaat tgttgggggt ttgaatttaa taaataacag taatccaaca actgctaaaa
    11461 tactccagaa caccaatgat agactattca ttcctgaatc cctgccttga cttctttttg
    11521 aaaaggcaag tccggttcag atagctcaat tttccctata catttgcaat ttttagcttc
    11581 acattttaac tgaagcaaac gagcaggtga accaatgtca gccatgctat cttctaaaat
    11641 atgccctagc ggcaaatctt ctaattggca aggagttacg tatccatctg ctcttatata
    11701 ccaagcaaga tatcctggtg tacaaaaatc tgttgtgaac gaactctctt cgtgctccca
    11761 atcaattatg ttcaggcgat ctccccattt atgacgtgct tccctaagct gtatttgaac
    11821 catttcttca aaatcaatat ccaaagcctt aaagccttct gtcgcacgtc caacagataa
    11881 cgtttttcct gcacgaaaga taaaagcacc cgcattggca cattgctcca ccacatctga
    11941 tacttcatca gcattggact cattaatggt catagcgaca atcactggaa tgtttgcttc
    12001 tgataatttt ttaatggtat tcatactttc tttaaagccg ccttttctgc ctcttaattg
    12061 gtcatgtgta ttatccatac catcaatact aatctgtaca gaaacattgc ctaagtgact
    12121 aagtaattca acttcttcat ctcgccagtt caatccatta ctaaatacat tcacattggt
    12181 aaacaacgaa cttgcaacaa cgactaattc tttaaaccct ttgatcagct ttgcttcacc
    12241 cccggtcagc gtaatatcag caactccatg ggctgctaac ttttgcataa ccaatatcca
    12301 ttgttcacta gatagttcct caggatatgg tttacctgag ctggcatagc aaaacgaaca
    12361 gcttaaatta caagcatttg tcaactgcaa ggtacaacta ataggtaaat atgaatctag
    12421 cgaacccgaa acgtgtaaag gctgatctaa cagcccttcc gtccaagcct ccgtaaatgg
    12481 atgggcacta agctcttctt ttaattggtc agcactcatc tcttcttttt tcataatctc
    12541 ccaaatacgt gccgttttat gaaggttttt gttttttgat aacagaaacg ccaactgtgc
    12601 tccacgtcca ctgagtctga aataaaacat actttttcta tcaatcatta cagcaccatg
    12661 aggctgtaaa tgaaccgcta actctggcaa atcaaaatct ttaacacgat catatgacat
    12721 ataaaatccc ccttaagaga aaataaggag tataagcaaa tacgctcaac tccctattct
    12781 caaatgttaa atagctctca tagcaggatg cggaagtgca caaacacgtg tcatagcaat
    12841 actcttcgag gcccaacagc ccatgcagcc agcagccttc acaatcgaag tacctcccgg
    12901 cttcataagt ccttttttac taacagattc ccattctttt tggtttcttt tcataagtaa
    12961 acctcctctc aatttttgca tagagtctat tgacatagct cccatgcgat acgataatac
    13021 cagattgcaa ttgtcgaagt aagggggatt ttgtatatta tcctaaaaat aacattaatt
    13081 agtataaata gaatatttta accctttaaa aatagaaaag ctgacaagct atcctctcga
    13141 gaaaaacagg agctcacccc taatttttca cttatgtttt gaatattttc ttgttctata
    13201 aacaaaacgt caaaaagacg atccattctg ttataaaaat tctgatgcct aatagattga
    13261 caaacaatct cttcgaggaa aataaatcaa gagattattt tcaaataaac tttagtgatt
    13321 aagaaagcaa tgactttagt taaatgaatg aagtctcctg taatttaaat caaatatcta
    13381 tactaaaaac cccttcggct aaaatatcca aaggggttaa acatcttact ccacagtaac
    13441 actcttcaca aggttacgct gcttatcgac atcacaaccg agatgcaggg catcattagt
    13501 aagcaatcag ctgcaaccga caacagaaac caacggaaac agagcaagcg ctgtgtttac
    13561 ttccggcaat acgaatatgt catccgcatt gtctaggcct ttcagcgaga tgatgcaagt
    13621 gtttactccc caagtggcaa cttccttgac gtttacgcga atgttcaggt ttacgctctc
    13681 ttgtgtttcc agtgttcgat caaggcaatc gtaccgtact tcagcggcaa agccttaaga
    13741 aatccctttc agcttcagtg cgccttcgac acatacagaa cgatgtcggc ccttggaagg
    13801 ctcatgcatg gactgacttt gaatgcttat aaaaaacacc cgcttgtata acgagcggat
    13861 gttagatctt tcgaaattat tgattgatat cttttagcgc ttgtttcggt tgcgaattga
    13921 aaatcagcaa tgatgcaata atggcaatca taacccctaa cgcaccaacc caggtaatcg
    13981 aggccaatga tacgttttcc acaaaaaccc ctcctatacc tgcgccgacc gccatggcga
    14041 attgcatcat tgactgattc atgctaagca aaacacctga catttccggt tctattgtag
    14101 ccaggtgaaa ttgctgtgtc ggaccggtag accatgcggc aaacgaccat aatatgagaa
    14161 tcaccaacac tccgatatag gaatgagtaa caagtgacag aagaatcagt gtgacgatat
    14221 gcaacgtcat cccgccaacg agtgtaaagg acactcccca tttatcggtg ctatatcccc
    14281 caaactttga tccaaccaaa ctggcaattc caaatataag caaaacacca ctgagcagct
    14341 tgccatttat acctgagatg ttcaagagat acggtgacaa ataagtgtaa gcaacagaat
    14401 atcccccgag ccagaagaaa gtgattgata atcccatagc cactttccgt tttttgaaaa
    14461 gagcaagctg ttgaagcaaa ggcacaggct tatccccttc agtatgcgga agggtaaaga
    14521 aaataacgac cattgcgatc aatcccaaca aagcaattgc tccaaataca gacttccagc
    14581 ctaatgctac tgctatcatt cttccaagcg gaacaccaat gattaaagaa gcggtaaatc
    14641 ccatcacgac cgtagcgatg gcacttccct gcttcccttc cgatgcaatt ttagcggcaa
    14701 tcgttaaggc ggtgacaacc accacacctg ctcccatcgc cataatgatc cgcgctgcaa
    14761 taaaccatcc ataaccaggc agtacaaaag ccaggacatt accgaacaca aacaaaccta
    14821 gggcatacat catcaatttg cgtctatcca tacttgctgt caacgccata agtacgggtg
    14881 tagaaagagc atatacaagt gagaaaatgg taataagctg gcccgcggca gctaaagtga
    14941 tcccgagagt atgagcaatt tgatccaaaa ttccggaaat gatgtactct gaggttccaa
    15001 ctaaaaagct gacaatggct aaaatataaa ttttccaagt gttagacata aaacattcac
    15061 tccttaatta tcaataaaca tatcacgaat tatcgatatg ttattataaa aaataaacac
    15121 atcgtaatat gtcgatatgt atggtgtaaa aataaacatc ttttgatgtt tatttttata
    15181 tctctgtttt aagaaagtca gcaagtttcc caatggcttc ttcatctctt ttgtaatatg
    15241 tgtactttcc aatacgctcc gccttaatca agccggctct taaaaggatg gtaagatatt
    15301 gagaagctgt cgattgcgtc attttcaatt tgtctgttat ttgactgaca cataccccga
    15361 ttgtgttcat atcaatccct tcatggggta caaaatgacg atcgggctcc ttcagccatt
    15421 gtaaaatttg cagccttgat tcatttgata aggctttgaa tacttcaatt ggttccatat
    15481 cgattattat atcgttatat ttcgatatgt caatccgttt ttggatatat ttaattaaag
    15541 gtttatctct gactaattcc gtgaaatgaa actgaagaca gcatatcaat tttgttcacc
    15601 gcttaaattt atcagcaagc tttacgaaat tggtctcata atcatgtcac taaacacttg
    15661 gaggaaccca gcaggtgaca aggatgtttt caattaaaat gaatttaata ttgttcaagt
    15721 gactaatcac cagcagcaaa tttagatgta aaaaacatcc gctcataaca acagcggatg
    15781 ttagatcttt cgacaggaat aacacaacag tgtactatga attgacatct ctttatgtcc
    15841 gcttaggata tgaataaaag ttatcaatga tgccataatt gtaaaacaaa agaatcggca
    15901 tttctttatg ttcaattcac aacaaattcc ataccgtcaa aacatttatt ttctttagat
    15961 tataagatct tttccaaatt tttctctaga tcattacata atttaaatac catcactcgt
    16021 tcacctgtcc gggagcttaa atcagtatga aaacttttca ctttttctcc ggttattttt
    16081 aagataatat ccttaaggcc ttctatacct gattcgacta actccgaacg agtttgtttg
    16141 atagataaca taccctcttt tgatccacaa actacatatt cggctggtgt taaaatccct
    16201 tttaaattga cgatgatcat gtcccgcagt atatcagtct taacagatac agacccccgt
    16261 ccaagataat ccttctccca ttgagtaatg gacttactga tctctgattc aatagaaccc
    16321 ttcgactttt tcatatctaa tacatctcct gagcaaaaaa attggcatat tctatttgtg
    16381 atttcgtctc attaatattc tcttacaaca tatccttcat atacaccttc aatatccaaa
    16441 tcagttttac cgtttcttgt gaccactatc attttggata acatattttc ttccatcata
    16501 gagtggacat gcaaaaatcg aacatttcct gaatgggttt cctcaacttc ttcataagat
    16561 ttaagatgat aaaaatcaat tgcttttcta attagttttt tcatacattc catattttca
    16621 cgatcaaacg agttcatgtc ctctattgtt ttcgtgacaa aatcagttaa attagcgctc
    16681 atacaatctc cttagaactg ctttctccat atatggtgtt tagaagttga acctgaattt
    16741 catcatgaca agcaatgatc aggtatggct tgacctgttt tagcatcagg cccctccata
    16801 attgagggtt ttccatcctt atgattaacg aataaacctc taactttaac atatgacggc
    16861 actagtggat gatgtcgaat catatcaaca cttttttcaa tggtgtcact gctattttca
    16921 ttaagccatt catcgaccgt accaccaaaa aattcaggct tgcaattttg aaagagataa
    16981 tccaatgttt gtattttatc tttcattgtt tcaagttgag ttagttcatt acctgcggaa
    17041 gtcttcttat cttttgttcc cactacaaaa atctcctcaa catcttcctg gtaaatcgca
    17101 aaaataacag atctcatgat ttctccataa ggatgtgaaa taccggcacc atagctttgt
    17161 atagtcaaca tattctctgc agaagtgtta gtcgcttctt gtaaaatagg ctccaaaccg
    17221 ttttcaatat ccgtcaaaaa taatactttt ttattttggt ttacattcat acagcacacc
    17281 tcttccttat gtttatcatt tttgtattga gtaacaaatc catttgataa atgcttagat
    17341 tcatcattac cagctttccc aacatccttc tggatcaaga ctagccagtc ggacccatcc
    17401 attttgaact ttttgcagaa atgctgagtc atgatttaat aaccgttcta catattctct
    17461 aggtgcttgg atgagtatca ataaacgaag aggagaatga taggcctcgt gatctgattc
    17521 catgacggat tgccaaggca gtccggctaa caagtcgctt gcattcccct gcataacgcc
    17581 gagacctgca gtaacggttt gagttgcttt atttccgctg ccataataat aaggtgctac
    17641 cgttgatgcg taatattgta aattaatcca ttgggctaca gttccaggtc ctgcaataat
    17701 atttgctagg agttcaccgc tttcatcctg cttccaatca taattatgga gaaaggctct
    17761 gccttccaaa tcacaatcct gagttagttc acgtttaccg ataataaaag cggcattacg
    17821 agccagtccc cattccggac gtatctcact ccaatcttcc gcaaatcggt ttgcctcagc
    17881 cttcggattt tttagcttcg attggaaatt cggtaattgg gctagacgtt ctgcgtttac
    17941 atgatgtctc actttcggca taacagcttc aatttgttca aatgcttctt gtgcagcttc
    18001 ggaaagctct ggtacataaa gccaatgtaa ttcatccacc gttgtattat gttcagccgc
    18061 tgcaaaaacc gtatcctcag ggattttaat tccttcagtt aaaagagctt ctcgtacctc
    18121 tgatagatta cataaagcag ctaaaactct tgcattaaat ccaccggccg ctccaccgca
    18181 ggcaccacaa tcaagggctg cggaataagg attattagtg ctttgactgc catgcccgca
    18241 gatcacgacc aagggtgcga tgttttctgt taaccccatc atttttaatg cttggcgagc
    18301 atagttcact ttttcttcat cagtaaaacc cacaggtatt tctgcctctg tagtatcatg
    18361 atgaagcgag agttttgtat caggtttgcg caaccaagcc tcacggagat tacgaatgaa
    18421 acgacccgcc tttcttggca caaagctacg tgctgccatt tgcagagtaa gccaaggtcc
    18481 acttagctca ggcagtagta agctcgaaag cgcattctgc ttcatcgttt taaaggtatg
    18541 gcttaaagaa tgaattgctt gcttccgttg attgtatttt ttgaatacat cctcatctgc
    18601 gaactctttt attttatttt gcggtttttg tatgatcggt aaggaagcat gactgtgttt
    18661 actgccaagt tcacaagttg caatcggcac cccgaagaaa ccagcaatac caatcgtttc
    18721 aaacgggcct tctttttcta gttgacgacg aaaaggttct gatcgtacat cgatgcagaa
    18781 tgctaattga gctaatgcag attttttacc gccggtttca cgttgtttcg agatgatctt
    18841 ctggcttaat cgatcagtgt acgtttgctc ccaagcttct aaccaaagtt tcttgcgaag
    18901 tttctcatca aagctgtagg caaatgataa atattcgttt tgttcaatgg ccgtcatctg
    18961 tgaccattct tctaatgtaa gcccacccca atgaatccaa gctgctataa ggggagcaat
    19021 tgaaattgtt ttcttagatc gttcattagt caaaggtaag tatggcttta taagagccca
    19081 ctccatggat attcgaaccg ctaaatattc tgttaggagt gcatgttcgt ggctcgattg
    19141 ctgggagcgc caaagcatca tccctgccca tccaggtaat gaaagtaaat gaccttcaag
    19201 ataagtctgg atttctgact ctgggatttc tagtgcgaat aaggcttcct gtaaagccaa
    19261 atgtgcctct ttcggccaat cctttaccct ttctcgctgc tttttgctaa gtgctggatc
    19321 atattgaatg agatgctgcc aagcacgata gaaaccttcc tcacgattag gcattgtcca
    19381 gcctgcttga gagtcatcaa gatataattt actccactta atgacatgat gatctagtat
    19441 attgactagc ctttcaccat cttgattctc tatatacgaa cttagtggct gcataaacac
    19501 attctcgata tgatccaatc cactacattc acctactaat ttctccagct catgtgatga
    19561 taaaaggtcg gaaggcaggg gatctaactt taatgcagca tgacaaaatc gctctgctac
    19621 gtcccgtggg atgtgatagg aatgtgaatc aagccaacgc tgcagcccca tttccacaaa
    19681 atcttcatca atctcacctt tattctttgc tgaacggatc atagacgcac tagggtatat
    19741 atcaacatcg cgagtgtttt tcaaccaact tgcaacctga tcaaaagatt ggttttcaag
    19801 tcccatccac ggattacgtg cagcaaatgt agaaataggc caaagtggcg caatcactcg
    19861 gctggcagat gtaatgaaaa cgttaagatc cctttcttga acatcaatat ctgtatctat
    19921 cttttttaca ttatctttcg ttaatacgga tgtaatgccc atctcagatt agctccttat
    19981 gaaatatatt gtttaaggta gtctgggtga ctctctactg actttggttt tgcttcacct
    20041 aatcggacta accaaagata gagtaccgcg aaaaaaacgg aagaacgatg acgagcaacc
    20101 cacgtaccta aagcactgcc aaagagtaag agacatacga caatcatgac agctgacatt
    20161 ggaggttgaa cactttgaaa aatggttgta tgcagccact tatagaaaag gttatgaatg
    20221 ataaaatata cgagggctgc tcctcctaaa acagttaagc cggcaattcg gccaattcgg
    20281 ccctctccaa aagcgacaag ctgagtccaa gaaacggaca atgaccaccc taagatcagc
    20341 gcactaatga attgatatcc ctctccagga gcagcgagcc aaaaagcaac gcctataact
    20401 aaggataaaa tccgaccagc catgacccat aaataggatg ttctttcatt agtacgagcc
    20461 gatacttcat gacgccctac tgctgaacca gcttgtagaa acaacgtagc cttgaataaa
    20521 ccatgtaaaa taagatgaat aatggctgct atataggcgc ctaatgcaca ctgaatgagc
    20581 ataaacccca tttgtccaat cgtggagcct actaactggc gtttataatc aacctggact
    20641 aaactaattc cagttccaat caatacagaa atgccagcaa gcagaagtaa gataatcgaa
    20701 gcgataccac catgaaatag aggtgaaaat cgagttagta ttattcctcc agcatttact
    20761 aaacctgcat gcataattgc agaaacaggg gttggagcaa caatagactc aaccaaccat
    20821 ctttggaatg gccattgagc tgcaggaatg atcaccgcca gtacaatcaa tagctgaatc
    20881 cctgttctct cccattctcc cagcccagct aaactttcat ttgttacaac caatgataac
    20941 tgccattgac ctgtggcatg aaaaagccac atcattgcga aaaacagaga aaaccaactt
    21001 aacaaaaata agcggccaga aaccttggct gcttcactag ccacttgcca agcactgttt
    21061 aacctaataa gtaaggttaa accaacaaga gttgctcccc aaaatagaac catcaagcgg
    21121 agatcgccac ttaaccatgt cattgaagca gcacctgttg tgaaagtaaa aagcgtaaaa
    21181 tattttcgat aagatcgatc ccccattaag taacgtacag aaaaacgctg aatgatgaat
    21241 ccaattgcaa gaacaaagaa agtcattaaa caagctaagg aatctaagtg ccaagggcca
    21301 acatttccac tcacaccact attggcaaga atcagtaagg aaaccaaaag tggtaaagcc
    21361 aagatcccaa tatgaatgcg aacaaaactc aagggtactc gcggatgtaa aaacaatagt
    21421 ccacttatcc cagaagccat aagcataata aaaaataatg ttaataatga agataaactc
    21481 agcgaaacta acattctaaa ttctcccttt tttaaaactc attattgttc aaaagacctt
    21541 tcaaacagat catatttgtc tattatttat ttcaattttt atttatctct atttttttcc
    21601 aacaaaaaag ccgacaactt caaaatttca atgattatgt tagatcattg aatcctgaaa
    21661 attgtcggct tcacttcaac taacttcagc gaagtttttt gaagtgctac cttattattg
    21721 gtctttactt tatgctatgt tttcatttcc tttaatatag tcctgattat caaataaatc
    21781 gactcatttt ctcttccttt tttattagga tactttttca tcctatcaat atttaaaatt
    21841 aaatatgaaa agaatgctaa aggcctacat attttaaaag gaaaaataaa catctgcatc
    21901 gattattaag ttacgtataa gatatgctaa attttaaaag ttgtcaagtt tatcagtaaa
    21961 ctggtcttta ctttcctcta aaataatcca acccattata gatgattcac tttcaatgag
    22021 gaacatccat ttcagatgaa gctcgctttt ccagatcgag gagcagtgtc ttcatttcga
    22081 atccgccccg atagccagtt aatgagccat tctttcctat tacacgatgg cacggtacag
    22141 taattaatac cggattagcc ccaatagccg cacctacagc acgaacagct gctggtttat
    22201 ttatttcatt tgcaatgtcg gaataggatt tcgtctgtcc ataaggaatt tcacaaagtg
    22261 cattccagac tgctagctga aattgcgtac cggcgtactc aactggaaca gtaaagtttt
    22321 tccgctttcc ttctagatat tgagtgattt caacggcata gggttcaagc ttatcatcat
    22381 cttcaacaag aagacttccc ggaaagcgtt tcctagccca ttcgaacaat tcctcgattg
    22441 gtttgttctg tgaacctaca aacacaagcc cctttaaagt tgaagcaata taaaaattcc
    22501 aatccttgaa cattagtaaa gaccaataaa gggttggttt attctttgtt tccattgtat
    22561 gtttcctcca ttttactcat ttgacgaaat tgtgctggtg tctgtccagt tttcttttta
    22621 aataaagtaa taaaataagg cgcgttagct atacccacac atatagcgat atctccaatc
    22681 gatttatttg tctgaatcaa atacttttta gccgcgtgta ctctaacttg ttgtatatac
    22741 tcaaccagcg taatgccttt aatcttttta aatgttcgat gcatatgata cggactccca
    22801 tgacaaatat ctgctaacga ttctagcgtt aatttttctg tgaaattttt atcaatgtat
    22861 tcagtaatta aatcaaccca ctcgctatca ggcatttttt cattagtggg cttgcaacgt
    22921 ttacaagggc gaaaatttgc gcggagagct tgtt
//
