LOCUS       NZ_CP070373            21074 bp    DNA     linear   CON 18-MAY-2024
DEFINITION  Streptomyces sp. MBT27 chromosome, complete genome.
ACCESSION   NZ_CP070373
VERSION     NZ_CP070373.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MBT27
  ORGANISM  Streptomyces sp. MBT27
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8400223)
  AUTHORS   Machushynets,N.V., Wu,C., Elsayed,S.S., Hankemeier,T. and van
            Wezel,G.P.
  TITLE     Discovery of novel glycerolated quinazolinones from Streptomyces sp.
            MBT27
  JOURNAL   J Ind Microbiol Biotechnol 46 (3-4), 483-492 (2019)
   PUBMED   30729343
REFERENCE   2  (bases 1 to 8400223)
  AUTHORS   Machushynets,N., Elsayed,S., Carrion,V.J., Siegler,M.A., de la
            Cruz,M., Genilloud,O., Hankemeier,T. and van Wezel,G.P.
  TITLE     New from old: conjugation of actinomycin X2 and anthranilamide to
            form the novel actinomycin L in Streptomyces sp. MBT27
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8400223)
  AUTHORS   Du,C., Machushynets,N. and van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2021) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
REFERENCE   4  (bases 1 to 8400223)
  AUTHORS   Machushynets,N.V., Wu,C., Elsayed,S., Hankemeier,T. and Van
            Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JAN-2020) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 1.8.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011751035.2-RS_2024_05_18
            Annotation Date                   :: 05/18/2024 03:23:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,575
            CDSs (total)                      :: 7,482
            Genes (coding)                    :: 7,345
            CDSs (with protein)               :: 7,345
            Genes (RNA)                       :: 93
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 137
            CDSs (without protein)            :: 137
            Pseudo Genes (ambiguous residues) :: 0 of 137
            Pseudo Genes (frameshifted)       :: 39 of 137
            Pseudo Genes (incomplete)         :: 114 of 137
            Pseudo Genes (internal stop)      :: 17 of 137
            Pseudo Genes (multiple problems)  :: 27 of 137
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:14:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5327890
            Orig. end                         :: 5348964
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070373.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MBT, Institute of Biology
            Leiden, Leiden University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21074
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="29"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11074](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11074
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(1461..1476)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.73"
                     /tool="antismash"
     gene            complement(1513..3006)
                     /locus_tag="GWQ54_RS23520"
     CDS             complement(1513..3006)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458453.1"
                     /locus_tag="GWQ54_RS23520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167160059.1"
                     /transl_table=11
                     /translation="MSGQPNTRLNDLFGLAGWSKGELARMVNRQAAAMGHPQLATDTSR
                     VRRWIDMGETPRDPVPRVLAALFTERLGRVVTIEDLGFDRHGRAGKRNDVRNIKNPDGL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALATGSVLSSAMHDWLHTDPVLSADAPR
                     HHDPLHADPAGFDRYEAAPIGSQEIDALERSVEVFRAWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDIGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPGEALDLMKLAKSGSGEETLPRTRAMLHTIEAWAQASMGRGQA
                     MRRTLGEAEELFVSDKGDVPPPSWMQMFDEADLHGMEALAFRTLAEHDPAAATIAQHHA
                     KQALELRVGGRQRSKIFDYISLASACFIADDPEQADRYARLALVSMGETSSHRTWDRLR
                     EMYRLTNQYAGHGKIQDLREEIQQALPQAPLKRSRVADI"
     misc_feature    3171..3185
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            3240..4370
                     /locus_tag="GWQ54_RS23525"
     CDS             3240..4370
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="GWQ54_RS23525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_167160057.1"
                     /sec_met_domain="APH (E-value: 6.8e-16, bitscore: 57.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSTPPRPHRPLGAGGGPYLDPTHAGSAYGAGRMPRRPG
                     AAPQPLSGRIDLSGPQGAQLRIAIASVQRICPEFNPVQVLRHSGRSVLIVGTTGRTTAV
                     AKCLLDHSPAWAERFRHEIAAYRAFVRHRPPVRVPRLIAADPDNCTLVIERMPGRAAAL
                     TRHPVEAPPRADVRAALGAIGRVNAWRPPAEMFGRPLDYALRIARYHELGLFTDRDLSD
                     LQKLIHGLALSGRVDWQFSHGDALLSNILLSPAGPVLVDWEHAGWYLPGYDLATLWAVL
                     GDAPVERRQIASAAQAAGPAARDAFLVNLMLVLTREIRTYETAVQRTMRDATPSSPVQN
                     APGVLSAGEQQRLLLRRLHDDCALARRAVRAAVGTR"
     misc_feature    3561..3563
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4465..5793)
                     /locus_tag="GWQ54_RS23530"
     CDS             complement(4465..5793)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102934.1"
                     /locus_tag="GWQ54_RS23530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_167160055.1"
                     /transl_table=11
                     /translation="MTSKQRIRLALATATAGALGLALAPATAASAAGSGTECPRVLKCD
                     WVPAAYQQTGDPANKEAYGNYDVSDRPNTNRIKYIVLHDTEETYATTLKIFQDPTRAAS
                     AHYVVRSGDGHVTQMVKTKDVAWQAGNWYINSDSIGIEQEGYATEGATWFTPAMYRSTA
                     ALVRYLADKYDIPLDRQHILGHDTVPPTTAGGTAAMHWDPGPYWDWNYFMGLLGRPTEQ
                     TGRPRGQLVTVNPVFKQNVQAFRDCEKNIDLPAQPSSAVPLYTQPSTTAPLFADPGLHP
                     PGQSGTNCAGDWGSKISATQQAVVAERKPGWTAIWWYGQEAWFQSPAHTRTATATAGYV
                     VRPKRGRTDVPVYGTAYPAAGDYPADFTAPRVSTPLAYTIKAGQSYPGGEPTPTGYYYA
                     PTIDSSYPYDHTYFPGSTRYVTVQIGHRIAFVKASDVDVVRVR"
     misc_feature    complement(5919..5934)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.55"
                     /tool="antismash"
     gene            complement(6114..6614)
                     /locus_tag="GWQ54_RS23535"
     CDS             complement(6114..6614)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849642.1"
                     /locus_tag="GWQ54_RS23535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_161244551.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLFGGRGPAMIIGNLPAGSPAREMAEGQVPFEVAQLLVALENDEPIEVVGTEDM
                     PVMQGDNLLIVRRLKLSESRISCVQFDRSDDVLVTIASWDRPITDDLYALLKPLPAELF
                     QQS"
     gene            complement(6808..9738)
                     /locus_tag="GWQ54_RS23540"
     CDS             complement(6808..9738)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173679.1"
                     /locus_tag="GWQ54_RS23540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_346346917.1"
                     /transl_table=11
                     /translation="MAETKGRGGVPRRMLFERDEELLLFDSMLDDLCGRAGEGSAPNGG
                     LLAIAGSAGLGKTTLVAEVRRKAAARGCTLLAARGSEQEEGVAFHVVRQLVQPVLAATS
                     EEEHRKILGSWYDIVAPAVGLVAGKSGVAPDPQGVRDGLDWLVTRFAVQYAPVVLVVDD
                     AHWADEETLAWLTSFALRAADLPLLIVVAYRPEELPRHAAEFRRLATRHGSRPLDLSPF
                     TPAAVSDLVRDVLGEGGDELFARECWALTAGNPYEAVELVARIRDRGIKPQYANATELR
                     ELASAVRGNGLIERLERLGPSAFRLTWAVAVLGTDARREMAAGVAGLGVEEMADAIGKL
                     RDARILAEQSDDHPDRLDFFHPLVGTAVYRAIPSAMRVAMHGQAAFAVSEAGLGATSAA
                     RHILEMHPENDRWAVRQLRAAARDYLRAGAPDAARRCLARALREPPALEERAEVLFELG
                     CSALLNEPATTVNHLKAALEEPELAPELREAVTYRLAQALAHTDRMGEAAAIVGAEAKN
                     SGSARTRLRMQAESFQWNVFRADEEDSPARSRSLARLAEHITGRGKAERYILGLRAWDA
                     MVRGEPAETALRYAEEALEGGLSWTDDNWGFEVPVLVALTFMYCDQPGRADELFTQGIA
                     DCERKGWRGAHLSFGLTLLGYIKFHRGRLSEAEDLVHSGLRIADRVGHQVPAQWFALGI
                     LIEILLARGRVQDAQELSDAYNYGQVVPNAVVYPDSETVYSELLIARGLRTDAEERLRA
                     VGRRLEPRGMRNPMWCPWRPLLAQTIAHTDPVEAAAIAQEGVEIARRFGTPGAVGRALH
                     AAAKVTSGADSLALMSEAVRQLEKSPAAYELAQALIDHGAMLSRAGLPQDAADLLMRGL
                     ESAALCGADALAARAREELAASGLRPLQLRAVDSDSLTSQEKAVAERAAQGWENRRIAE
                     ELGTKERTVELLLSGAFRKLGTNRDGLAGLLPHQSRGSGVRGVPGL"
     gene            10001..11074
                     /locus_tag="GWQ54_RS23545"
     CDS             10001..11074
                     /EC_number="4.2.3.157"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041624.1"
                     /locus_tag="GWQ54_RS23545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isoafricanol synthase"
                     /protein_id="WP_167160053.1"
                     /sec_met_domain="T1TS (E-value: 2.3e-85, bitscore: 286.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSTGRVRSARMRTGLVDIPFPARRHPRDALARRHTLDWLYEFGM
                     LAGEQATAEYDAMGLERLMAYFYPDASDAHLALATDLNAWFFVFDDQFDGPLGKRPDVV
                     LRQIDTVLRTMSDEAPVAGETTNRLAESFRDLWQRVTAGTPLLWQDRFRAHWREYLTAY
                     HWEALNRTRNGTLSLPGFLRGRRDSIGVQPCLDLVERCGGYTLPRELHGGVPLAEMREI
                     TADVVIFVNDMVSVDKELAAGDVNNSVIILMRQEACTVEQALRRVAVMANSRIARFQEL
                     TIELAAQLDKTALPEQVRANVDDYVDGMRALMSGNLAWSLETARYGEAGIAAVSEGRQR
                     PWARLFPEQATEEREGA"
     misc_feature    10436..10438
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11185..11421)
                     /locus_tag="GWQ54_RS23550"
     CDS             complement(11185..11421)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019883999.1"
                     /locus_tag="GWQ54_RS23550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_161244556.1"
                     /transl_table=11
                     /translation="MRTLAGHTRSGWDKPELDLSQAEWQSSSQGAGDVQIAFVEGFIAM
                     RNSGSPGSPSLIFSPAEWRAFVINARDGEFDLT"
     gene            complement(11559..12725)
                     /locus_tag="GWQ54_RS23555"
     CDS             complement(11559..12725)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971158.1"
                     /locus_tag="GWQ54_RS23555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_167160052.1"
                     /transl_table=11
                     /translation="MSKEPVAVVGVGQTKHVAARHDVSIAGLVREAAQRALEDAGLGWS
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVASNLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPIPFTQPLLAGAGGFFAPHVRAYMRRTGAPDTVGS
                     LVAYKDRRNALKNPYAHLHEHDITLEKVQASPMLWDPIRYSETCPSSDGACAMILTDRA
                     GAARSPRPPAWVHGGAMRSEPTLFAGKDFVSPQAGKDCAADVYRQAKIADPRREIDAVE
                     MYVPFSWYEPMWLENLGFAAEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGLAGEHQVDGARKALGHAYGGGSQFFAMWLVGAEPPTG"
     gene            complement(12722..13783)
                     /locus_tag="GWQ54_RS23560"
     CDS             complement(12722..13783)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057881.1"
                     /locus_tag="GWQ54_RS23560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_167160049.1"
                     /transl_table=11
                     /translation="MAPTPAARDVAIVAFAQSDHRRRTDELSEVELLMPVLHQVLDATG
                     LKTSDIGFTCSGSSDYLAGRAFSFTMALDGVGAWPPISESHVEMDGAWALYEAWVKILT
                     GEADTALVYGYGKSSPGEVRDVLTRQLDPYYVAPLWPDSVALAALQAQALIDAGETDEP
                     ALAAVAARSRDAASANSHAQVRGSRPQGDYVVHPLRTGDCPPIGDGAAAVILAAGDRAR
                     ELCARPAWIRGMDHRIEAHGLGERDLTDSPSTRLAGERAGAFERPVDTAELHAPFTSQE
                     IVLRKALRLGDDVAVNPSGGALAANPVMAAGLVRLGEAAARIHRGESDRALAHATSGPC
                     LQQNLVAVLEGES"
     gene            complement(13783..14763)
                     /locus_tag="GWQ54_RS23565"
     CDS             complement(13783..14763)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530286.1"
                     /locus_tag="GWQ54_RS23565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_167160047.1"
                     /transl_table=11
                     /translation="MAGSAGPEVLRAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRT
                     GDGRVLVPPVEYDPVTAEEIRDLVEVGATGTVTTWAWNPAPRRDQPLDRPFAWVLVQLD
                     GADTALLHALDAPGPEAVHSGMRVRVRWAAERTGAITDIACFEPGETDEPGGTREAGGE
                     PAAHSGRFDDPVTGIVAAARLDYTYSPGRAQSAYINGLSARRTVGERCPSCRKVYVPPR
                     GACPTCGVATEERVEVGPAGTVTTYCIVNIKAKNLDIEVPYVYAHIALDGAGLALHGRI
                     GGIPYDQVRMGLRVEPVWSEGGRYPDHYRPTGEPDADYETYKELI"
     gene            complement(15082..15882)
                     /locus_tag="GWQ54_RS23570"
     CDS             complement(15082..15882)
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 2.6e-52. Score:
                     169.5. Matches aSDomain:
                     nrpspksdomains_GWQ54_RS23570_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069072.1"
                     /locus_tag="GWQ54_RS23570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_167160045.1"
                     /transl_table=11
                     /translation="MGGTEHLTTHREGATLVLTLNRPEAKNALSLPLLVGLYDGWLEAD
                     ADDSIRSVVLTGAGGDFCAGMDLKALAGQGMAGDQYRDRLKADPDLHWKAMLRHHRPRK
                     PVIAAVEGYCVAGGTEILQGTDIRVAGAGATFGLFEVKRGLFPIGGSTVRLQRQIPRTH
                     ALEMLLTGRPYGAQEAARIGLIGRVVPDGTALDAALEIAEQINACGPLAVEAVKASVYD
                     TASMSEADGLAAELERGWPVFATADAKEGALAFAEKRAAVYRRA"
     aSDomain        complement(15109..15855)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GWQ54_RS23570_ECH.1"
                     /evalue="2.60E-52"
                     /label="GWQ54_RS23570_ECH.1"
                     /locus_tag="GWQ54_RS23570"
                     /protein_end="258"
                     /protein_start="9"
                     /score="169.5"
                     /tool="antismash"
                     /translation="HREGATLVLTLNRPEAKNALSLPLLVGLYDGWLEADADDSIRSVV
                     LTGAGGDFCAGMDLKALAGQGMAGDQYRDRLKADPDLHWKAMLRHHRPRKPVIAAVEGY
                     CVAGGTEILQGTDIRVAGAGATFGLFEVKRGLFPIGGSTVRLQRQIPRTHALEMLLTGR
                     PYGAQEAARIGLIGRVVPDGTALDAALEIAEQINACGPLAVEAVKASVYDTASMSEADG
                     LAAELERGWPVFATADAKEGALAFAEK"
     misc_feature    15937..15952
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    15942..15956
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.63"
                     /tool="antismash"
     gene            16050..17672
                     /locus_tag="GWQ54_RS23575"
     CDS             16050..17672
                     /NRPS_PKS="Domain: AMP-binding (8-438). E-value: 5e-67.
                     Score: 218.2. Matches aSDomain:
                     nrpspksdomains_GWQ54_RS23575_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606696.1"
                     /locus_tag="GWQ54_RS23575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_193587947.1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-68, bitscore:
                     230.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDVVPDREALVYIDHPGTGAERRLTYRQLDEAA
                     NRLAHHLIDAGLKPGEHLGLHLYNGIEYLQSVLAALKARLVPVNVNYRYVEEELVYLYR
                     DADLAALVFDAEFTERVAGALPRTEKLRHLVRVGAAPDGAPALAATAFAEAEARGSASR
                     GFAARSADDQFIIYTGGTTGMPKGVMWRQEDLFFAGLFGGEPAGEPVKRPEELAERVAK
                     SGSGLTFFPAPPLMHGTSTLTSFVAFNYGQRVVIHRKYVPAEVLRTIERERVTSVSLVG
                     DAMLRPLVDALHGPLRGTDMSSLFSVSSSGAIMSETVRDQLQALVPNALILNNFGSSES
                     GSNGKATDDSGPEKGFRLEVNERTQVVDPVSYEPVAVGEVGRLAQRGHVPLGYYNDPAK
                     TAETFFQKGAERWVLLGDMATVDEDGIVTVLGRGSQCINTGGEKVYPEEVEQALKAHPD
                     VYDALVAGVPDAKWGSHVAAVVQVRAGAAAPTLEGIQTHCRTRLAGYKVPRQLVIAPSI
                     QRSPSGKADYRWARSVAAEADGT"
     aSDomain        16074..17363
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GWQ54_RS23575_AMP-binding.1"
                     /evalue="5.00E-67"
                     /label="GWQ54_RS23575_AMP-binding.1"
                     /locus_tag="GWQ54_RS23575"
                     /protein_end="438"
                     /protein_start="8"
                     /score="218.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALVYIDHPGTGAERRLTYRQLDEAANRLAHHLI
                     DAGLKPGEHLGLHLYNGIEYLQSVLAALKARLVPVNVNYRYVEEELVYLYRDADLAALV
                     FDAEFTERVAGALPRTEKLRHLVRVGAAPDGAPALAATAFAEAEARGSASRGFAARSAD
                     DQFIIYTGGTTGMPKGVMWRQEDLFFAGLFGGEPAGEPVKRPEELAERVAKSGSGLTFF
                     PAPPLMHGTSTLTSFVAFNYGQRVVIHRKYVPAEVLRTIERERVTSVSLVGDAMLRPLV
                     DALHGPLRGTDMSSLFSVSSSGAIMSETVRDQLQALVPNALILNNFGSSESGSNGKATD
                     DSGPEKGFRLEVNERTQVVDPVSYEPVAVGEVGRLAQRGHVPLGYYNDPAKTAETFFQK
                     GAERWVLLGDMATVDEDGIVTVLGRGSQCIN"
     CDS_motif       16569..16619
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GWQ54_RS23575_0001"
                     /evalue="3.00E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="GWQ54_RS23575"
                     /protein_end="190"
                     /protein_start="173"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     CDS_motif       17181..17261
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GWQ54_RS23575_0002"
                     /evalue="5.50E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="GWQ54_RS23575"
                     /protein_end="404"
                     /protein_start="377"
                     /score="15.6"
                     /tool="antismash"
                     /translation="GEVGRLAQRGHVPLGYYNDPAKTAETF"
     gene            complement(<17726..19245)
                     /locus_tag="GWQ54_RS23580"
                     /pseudo=""
     CDS             complement(<17726..19245)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-266). E-value:
                     1.5e-29. Score: 95.2. Matches aSDomain:
                     nrpspksdomains_GWQ54_RS23580_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102920.1"
                     /locus_tag="GWQ54_RS23580"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="alpha/beta hydrolase"
                     /pseudo=""
                     /sec_met_domain="PF00561 (E-value: 1.6e-25, bitscore: 88.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.4e-15, bitscore:
                     56.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKFTTYDGTRIAYHLRGDGRPLICLPGGPMGASAYLGDLGGLTV
                     HRRLVLPDPRGTGDSDAPDDPASFRCDRQVADVEALRVHLGLDRLDLLAHSASGNLALL
                     YAARHPDRVRSLTLVAPGVRAVGIEVTEDDWRAAVALRAGEPWYEEGRAAFERLWAKEA
                     SWGEVLDAIRPFAYGRWDAAAQRHEALTRVVRNQALAGAYYADGAFDPAATVAALAGLA
                     APVLVIAGEYDGGPTPARAAELAALLPDAELVVQRGAGHSPWVDDPEAFVRTVAAFLDP
                     EVRTSTSMVSGSPSGCVARGPHRP"
     aSDomain        complement(18448..19182)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GWQ54_RS23580_Abhydrolase_1.1"
                     /evalue="1.50E-29"
                     /label="GWQ54_RS23580_Abhydrolase_1.1"
                     /locus_tag="GWQ54_RS23580"
                     /protein_end="266"
                     /protein_start="21"
                     /score="95.2"
                     /tool="antismash"
                     /translation="PLICLPGGPMGASAYLGDLGGLTVHRRLVLPDPRGTGDSDAPDDP
                     ASFRCDRQVADVEALRVHLGLDRLDLLAHSASGNLALLYAARHPDRVRSLTLVAPGVRA
                     VGIEVTEDDWRAAVALRAGEPWYEEGRAAFERLWAKEASWGEVLDAIRPFAYGRWDAAA
                     QRHEALTRVVRNQALAGAYYADGAFDPAATVAALAGLAAPVLVIAGEYDGGPTPARAAE
                     LAALLPDAELVVQRGAGHSPWVD"
     misc_feature    complement(19455..19469)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.2"
                     /tool="antismash"
     misc_feature    19456..19470
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.07"
                     /tool="antismash"
     gene            19469..20761
                     /gene="paaK"
                     /locus_tag="GWQ54_RS23585"
     CDS             19469..20761
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (73-331). E-value: 1.1e-22.
                     Score: 72.2. Matches aSDomain:
                     nrpspksdomains_GWQ54_RS23585_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550714.1"
                     /locus_tag="GWQ54_RS23585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_167160041.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-25, bitscore:
                     88.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPELDAGERLSRPELEALQLDRLRASLRHAYDHVGFYREAFDKA
                     GVHPQDCVSLADLARFPFTAKSDLRDHYPFGMFAVPETDIRRIHASSGTTGRPTVVGYT
                     ERDLDTWADVVARSIRAAGGRPGHKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGM
                     TARQVQLIQDFRPEIIMVTPSYMLTLLDEFERQGVDPRSTSLKVGIFGAEPWTQEMRTE
                     IEERFAIDAVDIYGLSEVMGPGVAQECVETKDGLHIWEDHFYPEVVDPLTGAVLPEGER
                     GELVFTSLTKEAMPVIRYRTRDLTRLLPGTARVFRRMEKVTGRSDDLVILRGVNLFPTQ
                     IEEIVLRTPGLAPHFQLRLTRQGRLDALTVRVEARADTTAERREDAARSIVAAVKDGIG
                     VSVAVEIVDPETIERSVGKFKRIVDLREPRG"
     aSDomain        19688..20461
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GWQ54_RS23585_AMP-binding.1"
                     /evalue="1.10E-22"
                     /label="GWQ54_RS23585_AMP-binding.1"
                     /locus_tag="GWQ54_RS23585"
                     /protein_end="331"
                     /protein_start="73"
                     /score="72.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="PFGMFAVPETDIRRIHASSGTTGRPTVVGYTERDLDTWADVVARS
                     IRAAGGRPGHKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVQLIQDFRPE
                     IIMVTPSYMLTLLDEFERQGVDPRSTSLKVGIFGAEPWTQEMRTEIEERFAIDAVDIYG
                     LSEVMGPGVAQECVETKDGLHIWEDHFYPEVVDPLTGAVLPEGERGELVFTSLTKEAMP
                     VIRYRTRDLTRLLPGTARVFRRMEKVTGRSDDLVIL"
     CDS_motif       20432..20494
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GWQ54_RS23585_0001"
                     /evalue="1.00E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="GWQ54_RS23585"
                     /protein_end="342"
                     /protein_start="321"
                     /score="12.0"
                     /tool="antismash"
                     /translation="TGRSDDLVILRGVNLFPTQIE"
ORIGIN
        1 gccgtcccat ctgttcgcgg accgtcccgc tccccaaccg cccgagcggg gcacggtcga
       61 cgcactgatc acgcagaccc gccgactgcg cggcggcgtg gacgcggtgc gccgcgacgc
      121 gctcgtggac gaggacgacg cccaagtacg ctggcagcgc gccctgtgcg acctggcggt
      181 ccatcaactc gacgacctgg gctcgcactt ggaccaactg cgcgacggcc tgaccgccga
      241 ggaggaggac gcggcggcgc tcgccgtgga gagcgccttc ggtgagggac cggaggccgc
      301 caccctgctc acccgggtcg gcagcgccga gtgggacctg ctgacggacg cggtgagctg
      361 gtccgaggag ctgttccaga tcttcggccg cgccgccggg agcggtggca tgtcgctcga
      421 cgaactgccc gccgtggtgg tcgaggacga ccaggccctg ctcaccacga tggtgaccga
      481 cgccctggtg gacggcaggc cgatcgacgg ggagttccgg atcgtacggc ccgacggcca
      541 ggtccgtacg ctccacatga tgggcgagcc cgtgctcgac gccgacggct gcaccgcttc
      601 gatgtgggcc gtcctgcgcg atgtgagtga gctgcgacgc agccagcggg ccgtgcggga
      661 gagccgcgac tgccttcagc gccggcgcca catcgcccag accgagcgcc ggctcgcggt
      721 cgagttgcag gaggccgtgc tgccaccgtg gcgcggctcc ctgcgactcc cgcagggcgg
      781 ccccgccgcg ctcgacatcg ccgcgcacta tctgccgtcc tccgccggcg ccctgatcgg
      841 cggcgactgg tacgacgcgc tcgaactccc cgacggcgcc tcgttattga ccgtcggcga
      901 cctcaccggc cacggcgtga ccgcgaccgg cgccatggcg atgctgctag gcgccctgcg
      961 cggcatggcc gtcgcgggca tcggcccggg ccccctgatg ggccacctca accagcttct
     1021 ggaacagacc gtgcagcccg ccctgggcag tgcggtctgc tgccgttacg agcccgccgg
     1081 gcgcaggctc atctggtccc aggccggcca ccccgccccg ctgctcttcc gcgacgggac
     1141 gggacgcgcc ctcagcgcac cggacggggt gctgctcggc gccacccacg gggctgccta
     1201 cggtcaggcc gaggtcaccc tgcacccggg cgacctgctc gtgctcggca ccggcgggct
     1261 gacccggcac ggcacgtccg acgacggcga gcagcgccgg ctgctcgcac tcgccccgct
     1321 cttcgacggc ggccgtacgg cccaggactg cgtacggatg atcgtcgagg agttcggcga
     1381 gcacgagcgt gccgacgacg cctgtgtgct ggtggcccgt atcgggtcct gacgcagggg
     1441 cctcctgacc cacaggcggc cgtgaacggc ctcgcaccgg ggggttgtac gtttcgggcg
     1501 tacaaccccc ttctagatgt ccgccacccg gctccgcttc aacggggcct ggggcagggc
     1561 ctgttggatc tcctcccgga ggtcctggat ctttccgtgg cccgcgtact ggttggtgag
     1621 ccggtacatc tcgcgcagcc ggtcccaggt gcggtgcgag gaggtctccc ccatcgacac
     1681 cagggccagg cgggcgtagc ggtccgcctg ttccgggtcg tcggcgatga agcaggccga
     1741 cgcgagcgag atgtagtcga agatcttcga gcgctgacgg ccgcccaccc gcagttcgag
     1801 ggcctgcttg gcgtggtgct gcgcgatggt ggccgcggcc ggatcgtgct cggcgagcgt
     1861 gcggaaggcc agggcctcca tgccgtgcag atccgcctcg tcgaacatct gcatccaact
     1921 gggcggcggc acatcgccct tgtcggagac gaagagctcc tccgcctcac cgagggtgcg
     1981 gcgcatcgcc tgcccgcgcc ccatggacgc ctgggcccat gcctcgatgg tgtgcagcat
     2041 cgcccgggtg cgcggcaggg tctcctcgcc cgagccggac ttggcgagct tcatcagatc
     2101 gagtgcttcg cccgggcggc ccaggtgaac catctggcgg gcggcccgcg agagggcctc
     2161 gccggcacgc gggcggtcgc cgccctcgcg ggccgcgtgg gcggcgatga cgaagtactt
     2221 ctgcgcggtg ggttccagac cgatgtcgtg cgacatccag cccgccagga cggcgaggtt
     2281 ggcggcgacg ccccacaggc ggcgctggag atggtcgggg tggcggtagg cgagcatgcc
     2341 gcccacctcg ttgagctggc ccaccaccgc cttgcgctgg agtccgccac cccgggaggc
     2401 gtcccaggcg cggaacactt cgaccgagcg ctccagcgcg tcgatctcct gagacccgat
     2461 gggagcggcc tcgtagcggt cgaacccggc ggggtcggcg tgcagggggt cgtggtggcg
     2521 gggggcgtcg gccgagagta cggggtcggt gtgcagccag tcgtgcatgg cgctgctgag
     2581 tactgagccg gtggcgagcg cggcgcccgc gcccaccaga ccgcgtcggt tgagcatgag
     2641 gtccattccc gtgaattcgg tgaggaccgc tgccgtccgt tcgggcgccc acggaaggcc
     2701 gtccggattc ttgatgttcc tgacgtcgtt ccgctttcca gcgcgcccgt gccggtcgaa
     2761 cccgaggtcc tcgatggtca cgacacggcc gagccgctcg gtgaacagcg ccgccagcac
     2821 cctgggcacc ggatcgcgcg gggtctcccc catgtcgatc caacgcctca cccgtgaggt
     2881 gtcggtggcc agttgggggt ggcccatggc cgccgcctgc cggttcacca ttctcgcgag
     2941 ttcgcccttg gaccatccgg cgaggccgaa caggtcgttc agacgggtgt tgggttgtcc
     3001 gctcacgtca agcccccagg ttctcggctg agttgacagt aatcccctgt cagatgcggc
     3061 gcgactattc gccagggttc gccagggcac gccagatggt gtgccacccg cggccgggtg
     3121 tcaggtaaga gagcgccacc ccgacccggg ggccggacct cattccccag ggtgcggctc
     3181 ggccaccggg acgggtagcg cacgcaactt gtcggcacac gaagggatct gtcaccccca
     3241 tgtacacagc atcgtcctcc gtgtccacgc cgccccggcc gcaccgtccc ctgggagcgg
     3301 gtggcggacc gtacctcgac cccacccacg ccggctcggc gtacggcgcg ggccggatgc
     3361 cgcgccggcc gggggcggcc ccgcagccgc tcagcggaag aatcgacctc tccggccccc
     3421 agggcgccca gctgcgcatc gcgatcgcct cggtgcagcg gatctgtccg gagttcaacc
     3481 cggtgcaggt gctgcggcac agcggacgct ccgtgctcat cgtcgggacg acaggacgca
     3541 cgacggccgt cgccaagtgt ttactggacc attcgcccgc ctgggccgag cgcttccggc
     3601 acgaaatagc tgcatatcgc gcgttcgtcc ggcaccgccc accggtgcgg gtgccgcggc
     3661 tgatcgccgc cgatcccgac aactgcaccc tggtgatcga gcggatgccc ggccgggcgg
     3721 cggccctgac ccgacacccg gtcgaggctc ccccgcgcgc ggacgtgagg gccgccctcg
     3781 gggcgatcgg gcgcgtcaac gcctggcggc cgccggccga gatgttcggc aggcccctgg
     3841 actacgcgct ccggatcgcg cgctaccacg agctcggcct cttcaccgac cgggatctga
     3901 gcgaccttca gaaactgatc cacggtctcg ccctgtcggg ccgggtcgac tggcagttct
     3961 cgcacggtga cgcgctcctg tccaacatcc tcctttcacc ggccggtccg gtcctggtcg
     4021 actgggagca cgcgggctgg tacctgcccg ggtacgacct ggcgacgctg tgggcggtcc
     4081 tgggcgacgc acccgtggag cgacggcaga tcgcctcggc cgcccaggcg gcgggtcctg
     4141 cggcgcggga cgcgttcctg gtgaacctga tgctcgtact gacccgggag atccggacgt
     4201 acgagacggc ggtgcagcgc accatgcggg atgcgacgcc gtcgagcccg gtgcagaacg
     4261 cccctggcgt gctgtccgcc ggggagcagc agcgactgct gctgcgcagg ctgcacgacg
     4321 actgcgcgtt ggcgcggcgg gcggtgcggg cggcggtcgg cacgcgctga cggccgggcg
     4381 aggggggaag cgggccgcgc gtccagtgcc gacacactgg gcgcgcggcc cgctgccata
     4441 ccctcggccg ggacctggcc aggcctagcg gacgcgtacg acgtcgacgt cggaggcctt
     4501 cacgaaggcg atccggtggc cgatctgcac cgtgacgtag cgggtgctgc cggggaagta
     4561 cgtgtggtcg tagggatagg acgagtcgat ggtgggggcg tagtagtaac cggtcggcgt
     4621 cggctcacca ccggggtagg actgtccggc cttgatggtg taggcgagcg gggtgctcac
     4681 ccggggcgcg gtgaagtccg cggggtagtc gccggccgcc gggtaggcgg tgccgtagac
     4741 cgggacgtcg gtccggcccc gcttggggcg tacgacgtag ccggcggtcg cggtggcggt
     4801 tcgggtgtgg gcggggctct ggaaccaggc ctcctgtccg taccaccaga tcgcggtcca
     4861 gcccggcttg cgttcggcga ccacggcctg ctgggtggca ctgatcttgc tgccccagtc
     4921 gcccgcgcag ttggtcccgc tctggcccgg ggggtggagg ccggggtcgg cgaacagcgg
     4981 tgccgtggtg gagggttggg tgtacagcgg gaccgcgctc gacggctggg cgggcaggtc
     5041 gatgttcttc tcgcagtcgc ggaaggcctg aacgttctgc ttgaacaccg ggttgacggt
     5101 gaccagttga ccgcgggggc ggccggtctg ctcggtgggg cggccgagca ggcccatgaa
     5161 gtagttccag tcccagtacg gccccgggtc ccagtgcatg gcggcggtgc cgccggccgt
     5221 ggtgggcggc acggtgtcgt gtccgaggat gtgctgacgg tccagcggga tgtcgtactt
     5281 gtccgcgagg tagcgcacca gggccgcggt cgagcggtac atcgcggggg tgaaccaggt
     5341 ggcgccttcg gtggcgtagc cctcctgctc gatcccgatg gagtcggagt tgatgtacca
     5401 gttgccggcc tgccaggcga cgtccttggt cttgaccatc tgggtcacgt gaccgtcgcc
     5461 ggaccgcacg acatagtgcg cggaggcggc gcgtgtcggg tcctggaaga tcttcagggt
     5521 ggtcgcgtac gtctcctcgg tgtcgtgcag gacgatgtac ttgatcctgt tcgtgttcgg
     5581 ccggtcggag acgtcgtagt tgccgtacgc ctccttgttg gcggggtcgc cggtctgctg
     5641 gtaggcggcc ggaacccagt cgcacttcag gacgcggggg cattcggtgc cggagcccgc
     5701 cgcgctcgcc gcggtggcgg gggccagggc caggcccagg gctccggccg tcgccgtagc
     5761 gagcgcgagt ctgatcctct gcttggacgt catggacaac ccttcttgcc ggaaggtgcg
     5821 gggctctctc gccgcagccg cgcgtgggtg cgcgcgggac acagtgcgac ccggcatgac
     5881 ggctcgtcaa gtacccctcg ggcgcgccga cttgtatcag tggacgagac cagtggcggc
     5941 ggccctgacc tgccggtgtc gcgacgggct caacggacgt acgggcaggc cgggtccagg
     6001 gtcggcggcg ttcgggagcc gccaccggcg ccgggcgctc cgggccccgg acatgaagcg
     6061 gcccggcacc tcgggcggag ggtgccgggc tgtcggccgg tgcgcgggcc cggtcagctc
     6121 tgctggaaga gctccgcggg cagcggcttc aggagggcgt acaggtcgtc cgtgatcggc
     6181 cggtcccagc tggcgatcgt gacgaggacg tcgtcgctgc ggtcgaactg gacgcaggag
     6241 atgcggcttt cggagagctt gagccggcgc acgatgagga ggttgtcgcc ctgcatcacc
     6301 ggcatgtcct cggtgccgac gacctcgatc ggctcgtcgt tctccagggc caccaggagc
     6361 tgggcgacct cgaagggaac ctgcccctcg gccatctcac gggccgggga gcccgccggc
     6421 agattgccga tgatcatcgc ggggccgcgg ccgccgaaca ggtcgtagcg caggaagaca
     6481 ccctggcagc tgccgtcggg ggcgggcagc agaccggcgc ccaggttgcc gggccagtca
     6541 cccgggtcca tggccaggac gtcgaagtcc gggcccgcgg gagtggcggc gctgcggcgg
     6601 cggaggaagg acatgccgtc aatggtacgt gcccccggcg ctccggcgga gccgggcccg
     6661 aagcgctggg cgggtcgaca cccggcgtcc tgcggggccc tggggcgtgc gggtggccgt
     6721 actccgctcc cgcgggcggg gcggcgtgcc acggccccgg ctcccccgcc ggtgggcgct
     6781 cgggggccgg ggccgtgccg gggtgcttca gaggccgggc actcctcgga ctccggagcc
     6841 gcgggactgg tggggcagca gcccggcgag tccgtcgcgg ttggtgccga gcttgcggaa
     6901 ggcaccggag agcaggagtt ccacggtgcg ctccttggtg ccgagctcct cggcgatgcg
     6961 ccggttctcc cagccctggg cggcccgctc ggccacggcc ttctcctggg aggtcagcga
     7021 gtccgagtcg acggcccgca gctggagcgg gcggagcccg gaggcggcga gttcctcacg
     7081 ggcccgggcg gccaaggcgt cggccccgca cagggcggcg ctctccaggc cgcgcatgag
     7141 caggtcggcc gcgtcctgcg gcagaccggc gcggctgagc atcgcgccgt ggtcgatcag
     7201 tgcctgggcc agctcgtagg cggccggaga cttttcgagc tgccggaccg cctcggacat
     7261 cagggccagg ctgtcggcgc cggaggtcac cttggccgcc gcgtgcaggg cgcggccgac
     7321 cgcacccggg gtgccgaagc ggcgggcgat ctcgacgccc tcctgcgcga tcgcggcggc
     7381 ctcgacggga tcggtgtggg cgatcgtctg ggccaggagc gggcgccacg ggcaccacat
     7441 cgggttgcgc atgccgcgcg gctccagcct gcggccgacc gcgcgcagcc gttcctcggc
     7501 atccgtacgc agtccccggg cgatgaggag ctcgctgtag acggtctcgg agtccgggta
     7561 gacgacggcg ttgggaacga cctggccgta gttgtaggcg tcggagagtt cctgcgcgtc
     7621 ctggacccgg ccgcgggcga gcaggatctc gatgaggatg ccgagcgcga accactgcgc
     7681 gggcacctga tggcccacgc ggtcggcgat ccgcagtccg ctgtgcacca ggtcctcggc
     7741 ctcggagagc cggccgcggt ggaacttgat gtagccgagc agcgtcaggc cgaaggacag
     7801 gtgcgcgccg cgccagccct tgcgttcgca gtcggcgatg ccctgggtga acagttcgtc
     7861 ggcgcgcccg ggctggtcgc agtacatgaa ggtgagcgcg accaggaccg ggacctcgaa
     7921 gccccagttg tcgtcggtcc aggagagccc gccctccagg gcctcctcgg cgtagcgcag
     7981 tgccgtctcg gcgggttcgc cgcgcaccat cgcgtcccag gcgcgcaggc cgaggatgta
     8041 gcgctcggcc ttgccgcgcc cggtgatgtg ctcggcgagc cgggccaggc tgcgcgagcg
     8101 cgccggggag tcctcctcgt cggcgcggaa gacgttccac tggaagctct cggcctgcat
     8161 gcgcagccgt gtacgggcac tgccggagtt cttggcctcg gcgcccacga tggcggcggc
     8221 ctcgcccatc cggtccgtgt gggccagcgc ctgggcgagc cggtaggtga cggcttcgcg
     8281 cagttccggg gcgagttcgg gctcttcgag ggccgccttg aggtggttga cggtggtggc
     8341 gggctcgttc aggagcgccg agcagccgag ttcgaagagg acttcggcgc gctcctccag
     8401 ggcgggtggt tcgcgcaggg cgcgggccag acagcgccgg gccgcgtccg gggcaccggc
     8461 ccgcaggtag tcgcgggcgg cggcgcgcag ctggcgcacc gcccaccggt cgttctcggg
     8521 gtgcatctcc aggatgtgcc gggccgcaga ggtggcgccg agtccggcct cgctgacggc
     8581 gaaggcggcc tggccgtgca tcgcgacgcg catggcggac gggatggcgc ggtagaccgc
     8641 ggtgccgacg agcgggtgga agaagtcgag ccggtccgga tggtcgtcgc tctgctcggc
     8701 caggatgcgg gcgtcgcgga gcttgccgat cgcgtcggcc atctcctcca cgccgagtcc
     8761 cgcgactccg gcggccatct cccggcgtgc gtcggtgccg agcacggcga cggcccaggt
     8821 gagccggaac gcggaggggc cgagccgctc caggcgttcg atgaggccgt tgccgcgtac
     8881 ggcggaggcc agttcgcgca gttcggtggc gttggcgtac tgcggtttga tgccacggtc
     8941 gcggatcctc gcgacgagct cgacggcttc gtaggggttg cccgcggtca gggcccagca
     9001 ttcgcgtgcg aacagttcgt cgccgccttc gccgagcacg tcgcgcacca ggtcgctgac
     9061 ggcggccggg gtgaacggcg agaggtccag cgggcgcgag ccgtgccggg tggcgagccg
     9121 gcggaactcg gccgcgtggc gcggaagttc ctcgggccgg taggcgacga cgatgagcag
     9181 cggcaggtcg gccgcgcgca gcgcgaacga ggtgagccag gccagggtct cctcgtccgc
     9241 ccagtgtgcg tcgtccacca cgagcaccac gggtgcgtac tggacggcga agcgggtgac
     9301 gagccagtcg aggccgtccc gcacgccctg cggatcgggt gccaccccgc tctttccggc
     9361 gaccaggccg accgccggtg cgacgatgtc gtaccaactc cccagtatct tgcggtgttc
     9421 ttcctcgctc gtcgcggcga ggaccggctg cacgagctgg cgtacgacgt ggaacgcgac
     9481 gccttcctcc tgctcgctgc cgcgtgcggc cagcagggtg cagccgcggg ccgcggcttt
     9541 tcgccggacc tcggccacca gggtggtctt gcccaggccg gccgatccgg cgatggcgag
     9601 cagtccgccg ttgggcgcgc tcccctcacc tgcccggccg cacagatcgt ccaacatgct
     9661 gtcgaacagc agcagttctt cgtcgcgctc aaagagcatc cggcgcggca cgccgccccg
     9721 gcccttcgtc tccgccacag cggtcccctt ctggcagtag caccgagcct acgccccgga
     9781 tacgtaccgt gacatgaata cccgacctcc gtctcctcct tgactgttta agttggctga
     9841 atccatgggt ggttggcatc caaatgtccc ggtggggcgc caggaggggc ctcgtacgcc
     9901 ccccatgcgc tgtcggactc cgccaccgcg cgactggctt cgggaggccc tcaccttgat
     9961 gattgaacta cgtacggagc agtgaaggag gcggtgccgc atgggcagca ctggcagggt
    10021 ccggtcggcc aggatgcgga ccggtctcgt cgacattccc tttccggccc gcaggcatcc
    10081 ccgggacgcc ctggcccggc gccacacgct cgactggctc tatgagttcg gcatgctggc
    10141 cggggagcag gccacggccg agtacgacgc gatgggcctg gagcgcctga tggcgtactt
    10201 ctatcccgac gcctcggacg cgcatctcgc actggcgacc gacctcaacg cctggttctt
    10261 cgtcttcgac gaccagttcg acggtccgct cgggaagcgc cccgacgtgg tgctgcgtca
    10321 gatcgacacg gtgttgcgca ccatgagtga cgaggctccg gtggcgggcg agacgacgaa
    10381 ccggctggcc gaaagttttc gtgatctttg gcaacgggtc accgcgggca cgccgttact
    10441 gtggcaggac cgcttccggg cgcactggcg cgagtatctg acggcgtatc actgggaggc
    10501 gctgaaccgc acccgcaacg gcaccctgtc gctgcccggc ttcctgcgcg gccgccggga
    10561 ctccataggc gtgcagccct gtctggacct ggtggagcgc tgcggcggct acacgctgcc
    10621 ccgggagctc cacggcgggg tgccgctggc cgagatgcgg gagatcaccg ccgatgtggt
    10681 catcttcgtc aacgacatgg tgtccgtgga caaggagctg gcggcgggcg acgtcaacaa
    10741 cagcgtgatc atcctgatgc ggcaggaggc ctgcaccgtc gaacaggctc tgcgccgggt
    10801 ggccgtcatg gccaactccc gcatcgcgcg cttccaggag ctgaccatcg agctcgccgc
    10861 ccagctcgac aagaccgcgc ttcccgagca ggtgcgggcg aacgtggacg actacgtcga
    10921 cggcatgcgt gccctgatga gcggcaacct ggcgtggtcc ctggagaccg cgcggtacgg
    10981 cgaggcgggc atcgccgccg tcagcgaggg ccgtcagcgg ccctgggcgc ggctcttccc
    11041 cgagcaggcc acggaggagc gggaaggcgc ctagcgttca cccggcatat gaggaggggg
    11101 tgttgaggag gcaaccggcc tcctcaacac cccctcctga cacgaaggcg caccggcggg
    11161 accggcagcc gcggggcgcg gacgctaggt gaggtcgaac tcgccgtcgc gcgcgttgat
    11221 cacgaaggcc cgccattccg cggggctgaa gatcagcgac gggctgccgg ggctgccgct
    11281 gttgcgcatg gcgatgaaac cctcgacgaa ggcgatctgg acgtcccccg ccccctgact
    11341 gctcgactgc cactcggcct gactgaggtc gagctccggc ttgtcccagc cggaacgggt
    11401 gtgacccgca agggtccgca aggtgtgctg ggttgtgctg gtgtcagcca cgtccgtgct
    11461 cctccccggt tctgtcgttc ggggccaccc tagcgatcgt ccgcggggac ggacaggcca
    11521 cggaaggagt acccgggccc gcccgccgcg aacgggcctc agccggtggg cggttcggcg
    11581 ccgacgagcc acatcgcgaa gaactgggag ccgccgccgt aggcatggcc gagggccttg
    11641 cgggccccgt ccacctggtg ttcgccggcc agcccgcgca cctggagtgc cgcctcggcg
    11701 aagcggatca tgccggaggc tccgatggga ttggtggaca gcaccccgcc cgaggggttc
    11761 acggggagat caccgtcgag ttccgtgacg ccggcctcgg tgagcttcca cccctcgccc
    11821 tcggcggcga agcccaggtt ctccagccac atcggctcgt accaggagaa cggcacgtac
    11881 atctcgaccg cgtcgatctc gcgccgcggg tcggcgatct tggcctgccg gtacacgtcg
    11941 gccgcgcagt ccttgcccgc ctgcggggag acgaagtcct tgcccgcgaa cagggtcggc
    12001 tcgctgcgca tcgcgccgcc gtgcacccag gcgggcgggc ggggcgaacg ggccgcgccc
    12061 gcacggtcgg tgaggatcat cgcgcaggcc ccgtcggagg acgggcacgt ctcggagtag
    12121 cggatcgggt cccacagcat cggggaggcc tggaccttct ccagggtgat gtcgtgctcg
    12181 tgcagatgcg cgtacgggtt cttcagggcg ttgcgccggt ccttgtacgc gacgagggag
    12241 cccaccgtgt cgggggcgcc ggtgcgccgc atgtacgccc ggacgtgcgg ggcgaagaag
    12301 cccccggccc ctgcgagcag cggctgcgtg aacgggatcg gcagggacag gccccacatg
    12361 gcgttggact cggactgctt ctcgaaggcg agggtgagca cggtccggtg cacccgggcg
    12421 gcgaccaggt tggaggcgac cagcgcggtc gagccgccga cggagcccgc ggtgtgcacc
    12481 cgcagcatcg gcttgccgac cgcgccgagc gcgtcggcga ggtagagctc gggcatcatg
    12541 acgccctcga agaagtcggg cgccttgccg atgacgacgg cgtcgatgtc cgaccagccc
    12601 aacccggcgt cttccagagc ccgttgggcg gcctcgcgga cgagtcccgc tatcgacacg
    12661 tcgtgccggg cggccacgtg cttggtctgg ccgacgccga cgacggccac gggttccttg
    12721 ctcatgactc cccctccagg acggcgacca ggttctgctg aaggcagggg ccggacgtgg
    12781 cgtgcgcgag ggcccggtcg gactcgcccc ggtggatgcg ggcggcggcc tcgccgagcc
    12841 gtacgaggcc ggccgccatc acggggttcg cggcgagcgc gccgccggac gggttgacgg
    12901 cgacgtcgtc gccgagccgc agcgccttgc gcaggacgat ctcctgcgag gtgaacggtg
    12961 cgtgcaactc ggcggtgtcc acgggccgtt cgaaggcgcc ggcccgttcg ccggcgagcc
    13021 gggtggacgg cgagtcggtg aggtcgcgct cgcccaggcc gtgcgcctcg atgcggtggt
    13081 ccatgccgcg gatccaggcg ggccgcgcgc acagctcgcg ggcccggtcg cccgcggcga
    13141 ggatcaccgc ggcggcgccg tccccgatgg gcgggcagtc cccggtacgc aacggatgca
    13201 ccacgtagtc gccctgcggg cgcgaacccc gcacctgcgc atgggagttg gcgctcgcgg
    13261 cgtcccggct gcgggccgcg acggcggcga gcgcgggctc gtcggtctcc cccgcgtcga
    13321 tgagggcctg ggcctggagg gcggcgagcg cgaccgagtc gggccacagc ggcgccacgt
    13381 agtacgggtc gagctggcgg gtgagtacgt cgcgcacctc gccgggagag gacttcccgt
    13441 agccgtagac gagcgcggtg tcggcctccc cggtgaggat cttcacccag gcctcgtaga
    13501 gcgcccaggc gccgtccatc tccacgtggg actcggagat cggcggccag gcgccgaccc
    13561 cgtcgagcgc catggtgaag gagaaggcgc ggcccgcgag gtagtcgctg gagccggagc
    13621 aggtgaagcc gatgtcgctg gtcttcaggc cggtggcgtc caggacctgg tgcagcacgg
    13681 gcatgaggag ctcgacctcg gacagctcgt cggtgcggcg ccggtggtcg ctctgcgcga
    13741 acgcgacgat cgccacgtcc cgggcggcgg gtgtgggcgc catcagatca gctccttgta
    13801 cgtctcgtag tcggcgtcgg gttctccggt gggccggtag tggtcggggt agcggccgcc
    13861 ctcgctccac accggctcca cccgcagccc catccgcacc tggtcgtagg ggatgccgcc
    13921 gatccgcccg tgcagggcga gccccgcgcc gtcgagcgcg atgtgggcgt agacgtaggg
    13981 cacttcgatg tcgaggttct tcgccttgat gttcacgatg cagtacgtgg tgacggtccc
    14041 ggcgggcccg acctcgaccc gctcctcggt ggcgaccccg caggtggggc aggcgccgcg
    14101 cggtggcacg tacaccttgc ggcaggaggg gcagcgctcg ccgacggtcc ggcgggcgga
    14161 gaggccgttg atgtacgcgg actgggcgcg ccccgggctg taggtgtagt cgagccgcgc
    14221 ggccgcgacg atcccggtga cgggatcgtc gaaccggcca ctgtgcgcgg cgggttcacc
    14281 tcccgcctca cgtgttccac cgggttcatc cgtttcaccg ggttcgaagc aggcgatgtc
    14341 ggtgatggca ccggtgcgtt cggcggccca gcggacgcgg acgcgcatcc cgctgtgcac
    14401 ggcctcgggg ccgggcgcgt ccagggcgtg caggagggcg gtgtcggcgc cgtccagctg
    14461 gacgagcacc cacgcgaagg gccggtcgag gggctggtcg cggcgcgggg cgggattcca
    14521 ggcccaggtg gtgacggtgc cggtggcacc gacctcgacg agatcgcgga tctcctcggc
    14581 ggtgacgggg tcgtactcga cgggcggcac gagaacacgc ccgtcccccg tacgcacccc
    14641 gagcacggtc cgctcccgca gccccgtgag gaaggcgctc tggaccggcc ccagggaccg
    14701 ggtgaaggga aactcgacaa caagcggcgc ccgcaacacc tcgggcccag cagagccagc
    14761 catgatccaa ctccttaagt accgtcaatt accgggccac ttggagcccg tcgggcgttc
    14821 gaggctccgg gccgctcgca gccccctccg gcttacgggg ccccgggcgg gcacctgcat
    14881 tccgtccggc gttcgaggct ccgggccacc tacggcctct gacgtacgag gcccctggcg
    14941 gccacccgca ttccgtcgat cgatgggggc tccgggccac ctgcggcccg tccggcgttt
    15001 cgaggacgag cggcctcgca aggcgagccg ggtccggggc ggagcccccg cgcccctctc
    15061 ccggaggacg gaggcggggg ctcaggcccg ccggtatacg gcggcccgct tctcggcgaa
    15121 cgccagcgcc ccctccttcg catccgccgt ggcgaacacc ggccacccgc gttcgagctc
    15181 ggccgccagc ccgtccgcct cgctcatgga cgccgtgtcg tacacggagg ccttgaccgc
    15241 ctcgacggcg agcggcccgc acgcgttgat ctgctccgcg atctccagcg ccgcatcgag
    15301 cgccgtcccg tccggcacca cccgcccgat cagcccgatc cgggccgcct cctgcgcacc
    15361 gtacggccgc cccgtcagca gcatctccag cgcgtgcgtg cgcggaatct gccgctggag
    15421 gcgcacggtc gagcccccga tcgggaagag cccgcgcttc acctcgaaga gcccgaacgt
    15481 cgccccggcc cccgcgaccc ggatgtcggt gccctggagg atctcggtac ccccggccac
    15541 gcagtacccc tcgacggcgg cgatcacggg cttgcggggc cggtggtggc gcagcatcgc
    15601 cttccagtgc agatcggggt cggccttgag ccggtcccgg tactggtccc cggccatgcc
    15661 ctgccccgcc agggccttga ggtccatccc ggcgcagaag tcaccgcccg cgccggtgag
    15721 cacgaccgag cggatcgagt cgtccgcgtc ggcctccagc cagccgtcgt agagccccac
    15781 cagcaaggga agcgacagcg cgttcttcgc ctccggccgg ttcagggtga gcaccaaggt
    15841 ggcgccctcg cgatgcgtcg tgaggtgttc cgtaccgccc acagccgtcc tcccgtctca
    15901 agacctagaa caggttgcag taggggcggt gtcagttcaa tagttttctg acactcagtc
    15961 agttttcttc tgcggcaccc cttccctgtt gtgcgcggct ttgttctgat gacccccgag
    16021 ttcagtcggg gccggtgtca ggaggaatgg tggagtacaa ccttgccgac ctgttcgagt
    16081 ccgtcgtcga cgtggtcccg gaccgcgaag cgctcgtgta catcgaccat cccggaacgg
    16141 gcgccgaacg cagactgacg taccgtcagc tggacgaggc ggcgaaccgg ctcgcgcacc
    16201 acctcatcga cgcgggcctg aagcccggtg aacacctggg cctgcacctc tacaacggca
    16261 tcgagtacct gcagtccgtg ctcgccgcgc tcaaggcgcg gctggtgccg gtcaacgtca
    16321 actaccgcta tgtggaagag gagttggtct atctctatcg ggacgccgac ctcgcggccc
    16381 tcgtcttcga cgccgagttc accgagcggg tcgcgggcgc actgccccgc acggagaagc
    16441 tgcggcacct ggtccgggtc ggggccgctc ccgacggggc cccggccctg gccgcgacgg
    16501 cgtttgccga ggcggaggcc cggggctccg cctcgcgggg cttcgcggcg cgttcggcgg
    16561 acgaccagtt catcatctac acgggcggca ccacggggat gcccaaggga gtgatgtggc
    16621 gtcaggagga cctgttcttc gccgggttgt tcggcggcga accggccggt gaaccggtga
    16681 agcgccccga ggagctggcc gaacgggtcg ccaagagcgg ctcgggcctc accttctttc
    16741 ccgctccccc gctcatgcac ggcacctcca cactgacctc cttcgtcgcc ttcaactacg
    16801 gccagcgggt ggtcatccac cgcaagtacg tccccgcaga ggtgctccgt acgatcgaga
    16861 gggagcgggt caccagcgtc tccctggtcg gtgacgcgat gctgcggccc ctcgtcgacg
    16921 cgctgcacgg cccgctccgg ggcaccgaca tgtcctcgct gttcagcgtg tcatcgtccg
    16981 gcgcgatcat gtccgagacg gtgcgcgacc agttgcaggc gctggtgccg aacgcgctga
    17041 tcctcaacaa cttcggctcg tccgagtccg gctccaacgg caaggccacg gacgactcgg
    17101 gcccggagaa gggcttccgg ctggaggtca acgagcgtac gcaggtggtc gatccggtgt
    17161 cgtacgagcc ggtcgcggtc ggcgaggtgg ggcggctcgc ccagcgcggg cacgtgccgc
    17221 tgggctacta caacgacccg gcgaagaccg ccgagacctt cttccagaag ggtgccgagc
    17281 ggtgggtgct gctcggcgac atggcgaccg tcgacgagga cggcatcgtc acggtgctcg
    17341 ggcggggctc gcagtgcatc aacaccggcg gcgagaaggt ctacccggag gaggtcgagc
    17401 aggccctcaa ggcgcatccc gatgtgtacg acgcgctggt ggccggggtg ccggacgcca
    17461 agtggggcag ccacgtggcg gcggtggtcc aggttcgcgc cggggcggcc gcgccgacgc
    17521 tcgaagggat acagacccac tgccgcaccc gcctcgccgg ctacaaggtg ccccggcagc
    17581 tggtgatcgc ccccagcatc cagcgctccc ccagcggcaa ggcggactac cgctgggcgc
    17641 gctcggtcgc cgccgaggcc gacggcacct gatcggacgg cagggacggc agggacggca
    17701 gccgaccgga gccgcgcgtc cggccgatac cgaactcccc gagtgcggac aggaattgtt
    17761 cgggccgatc ggtgtgcacg aggtggccgg cgccgatggt gacgaggcgg gcgtccggta
    17821 tccgcgaggc catccaggcc ggcgtcttct ggtcgacgtg gccggcccgg ccgcccgcga
    17881 cgaccagggt gggcgtggcg atggcggcga accggccgcg ccaggccggg tcggggtcgt
    17941 tcagctgggc gtcggtggcc tcgatgacgg tccagtcgaa gcccgttgcc cgcccggggc
    18001 gctcggcggg gccgcgcggc gggtcgagcg ggaagaacgg cggagtctcc tccagcacga
    18061 gcctgccgat gaggcctagc gcctcctcgg cgagcagcgc cgcggccgcg ccacccatgg
    18121 agtggccgac cgagtcggcg ccggtcaggc cgagttcggt gatgaatccg tgcagatcgc
    18181 cgcggaacac ctccaaggag tagctgcccg gccagtcgct cagaccgtgg ccccgcaggt
    18241 cgagtgcgta cgcccggtgg gcggccgcga ggcgttcggc gatgtcgtcc cagtcgcggc
    18301 tgtcgcagcc ccggtcgtgc acgaggatca cgggcggtgc ggtccgcggg ccacgcaccc
    18361 gctgggcgag ccggacacca tcgacgtcga cgtgcgcact tccgggtcga ggaaggcggc
    18421 gaccgtacgc acgaaggcct ccgggtcgtc gacccacggg gagtgcccgg cgccccgctg
    18481 cacgacgagt tcggcgtccg ggaggagggc ggccagttcg gcggcgcgcg ccggggtcgg
    18541 tccgccgtcg tactcgcccg cgatcaccag gacgggcgcg gcaagccccg cgagggcggc
    18601 gacggtggcc gccgggtcga aggcgccgtc cgcgtagtag gcgcccgcca aggcctggtt
    18661 ccgcacgact cgggtgaggg cctcgtgccg ctgggccgcc gcatcccacc gcccgtaggc
    18721 gaagggcctg atggcgtcga ggacctcgcc ccaagaggcc tccttcgccc acagtcgctc
    18781 gaaggccgcc cgcccctcct cgtaccaggg ctcgcccgcc cgcagggcga cggccgcccg
    18841 ccagtcgtcc tccgtcacct cgatgcccac ggcgcggacg ccgggcgcga ccagggtcag
    18901 cgagcggacc cggtcggggt ggcgggcggc gtacaggagc gcgaggttcc cggaggcgga
    18961 gtgggcgagc agatcgaggc ggtcgagtcc gaggtggacg cgcagcgcct ccacatcggc
    19021 cacctgacgg tcgcagcgga aggacgccgg gtcgtccggc gcgtccgagt cccccgtgcc
    19081 ccgggggtcg ggcagcacca gccgacggtg cacggtgagc cctcccaggt ccccgaggta
    19141 ggcggaggcg cccatcgggc cgcccggcag acagatcagc ggccggccgt cgccgcgcag
    19201 gtggtaggcg atccgggttc cgtcgtacgt cgtgaacttc ggcatgcggc cgatcctcac
    19261 agccgccctg cgcgcccggc aatcccgttt cgcccacggc acgatcatga acggccgccc
    19321 ccgcccaggc ggggcgctcc gacttgtcca caggccttga cggacccctc gggctgctga
    19381 attactgatc cgacacagat cgaccgaatg atcggtcgtc cgatttcgtc gccccttccc
    19441 cgggcggagc gaggacggga gcgcacccat ggcacctgag ctggacgcgg gcgagcggct
    19501 gagccgcccg gagctggagg ccctgcagct cgaccggctg cgtgcctcgc tgcgtcacgc
    19561 ctacgaccac gtcgggttct accgggaggc cttcgacaag gccggggtgc acccgcagga
    19621 ctgcgtctcg ctcgccgatc tcgcgcgctt ccccttcacc gccaagtccg atctgcgcga
    19681 ccactacccg ttcgggatgt tcgcggtccc cgagaccgac atccggcgca tccacgcctc
    19741 cagcggcacg acgggccgcc cgaccgtcgt cggctacaca gagcgggacc tggacacctg
    19801 ggcggacgtg gtggcccgct cgatccgcgc ggcgggcggc aggccgggcc acaaggtcca
    19861 tgtggcgtac gggtacggcc tgttcaccgg cggtctgggt gcgcactacg gggccgagcg
    19921 gctcggctgc acggtgatcc cggcctccgg tggcatgacg gcgcgtcagg tgcagctgat
    19981 ccaggacttc cgtccggaga tcatcatggt gaccccgtcc tacatgctca cgctgctcga
    20041 cgagttcgag cggcagggcg tcgacccccg cagcacctcg ctcaaggtgg gcatcttcgg
    20101 cgcggagccg tggacgcagg agatgcgcac cgagatcgag gagcggttcg cgatcgacgc
    20161 ggtcgacatc tacggcctgt cggaggtcat gggcccgggc gtcgcgcagg agtgcgtgga
    20221 gaccaaggac gggctgcaca tctgggagga ccacttctac ccggaggtgg tggacccgct
    20281 gaccggcgcg gtgctgccgg agggcgagcg cggcgagctg gtcttcacct cgctcaccaa
    20341 ggaggcgatg ccggtgatcc gctaccggac aagggatctg acccggctgc tgcccggtac
    20401 ggcgcgggtg ttccggcgga tggagaaggt gaccgggcgc agtgacgacc tggtgatcct
    20461 gcgcggggtg aacctcttcc ccacccagat cgaggagatc gtgctgcgca cgcccggcct
    20521 cgccccgcac ttccagctgc gcctgacccg ccagggccgg ctcgacgcgc tgacggtacg
    20581 cgtggaggcc cgggcggaca ccaccgcgga gcggcgcgag gacgccgccc gctcgatcgt
    20641 cgcggcggtc aaggacggga tcggcgtctc cgtggcggtg gagatcgtcg accccgagac
    20701 catcgaacgc tcggtgggca agttcaagcg catcgtcgac ctgcgggagc cgcgcggctg
    20761 acaaccggtg ctgccccgga ccggcatgac gggtgttcag gcgaatcggt cacgcagttc
    20821 gcgcttgagg atcttgccgc ttgcgttgcg cggcagcccg tccacgaaca ggacccgctt
    20881 gggcgccttg aagtgcgcaa gcaactcccg ggcatggttg atgagttggg cctcggtgac
    20941 cgatccctgc gtaccctcgc gccgtacgac gaacgcggtg accgcctcga tccagcgctc
    21001 gtcgggcagc cccaccacgg cggcctcggc gaccgcggga tgggtgtaga gggcgtcctc
    21061 gacctggcgc gagg
//
