LOCUS       NZ_CP070373            22673 bp    DNA     linear   CON 18-MAY-2024
DEFINITION  Streptomyces sp. MBT27 chromosome, complete genome.
ACCESSION   NZ_CP070373
VERSION     NZ_CP070373.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MBT27
  ORGANISM  Streptomyces sp. MBT27
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8400223)
  AUTHORS   Machushynets,N.V., Wu,C., Elsayed,S.S., Hankemeier,T. and van
            Wezel,G.P.
  TITLE     Discovery of novel glycerolated quinazolinones from Streptomyces sp.
            MBT27
  JOURNAL   J Ind Microbiol Biotechnol 46 (3-4), 483-492 (2019)
   PUBMED   30729343
REFERENCE   2  (bases 1 to 8400223)
  AUTHORS   Machushynets,N., Elsayed,S., Carrion,V.J., Siegler,M.A., de la
            Cruz,M., Genilloud,O., Hankemeier,T. and van Wezel,G.P.
  TITLE     New from old: conjugation of actinomycin X2 and anthranilamide to
            form the novel actinomycin L in Streptomyces sp. MBT27
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8400223)
  AUTHORS   Du,C., Machushynets,N. and van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2021) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
REFERENCE   4  (bases 1 to 8400223)
  AUTHORS   Machushynets,N.V., Wu,C., Elsayed,S., Hankemeier,T. and Van
            Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JAN-2020) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 1.8.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011751035.2-RS_2024_05_18
            Annotation Date                   :: 05/18/2024 03:23:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,575
            CDSs (total)                      :: 7,482
            Genes (coding)                    :: 7,345
            CDSs (with protein)               :: 7,345
            Genes (RNA)                       :: 93
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 137
            CDSs (without protein)            :: 137
            Pseudo Genes (ambiguous residues) :: 0 of 137
            Pseudo Genes (frameshifted)       :: 39 of 137
            Pseudo Genes (incomplete)         :: 114 of 137
            Pseudo Genes (internal stop)      :: 17 of 137
            Pseudo Genes (multiple problems)  :: 27 of 137
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:14:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4693284
            Orig. end                         :: 4715957
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070373.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MBT, Institute of Biology
            Leiden, Leiden University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22673
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="21"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22673
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22673
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12673](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12673)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            958..1914
                     /locus_tag="GWQ54_RS20610"
     CDS             958..1914
                     /EC_number="2.1.1.45"
                     /GO_function="GO:0004799 - thymidylate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006231 - dTMP biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012524.4"
                     /locus_tag="GWQ54_RS20610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thymidylate synthase"
                     /protein_id="WP_167160968.1"
                     /transl_table=11
                     /translation="MLRWLIEEPAYRNAPRGYASREQLGVSFRIARADQRVPFVPARRL
                     NIVFNFAEALWYLAGRDDLDFIAYYAPSIRKYSADGHRLTGTAYGRALFGAAEGRPDQW
                     PAVVETLREDPDSKRAVIQIFRGEELQVSGNPDVSCTLGLQFLLREGALHAVGFMRAND
                     VYRGMSSDVFSFTFLQEMLARELGVPVGSYVHQVGSLHLYDPDHSRALEVLADPAADEP
                     SAWSFPLMPEGDNWPWVREVLAVEEQLRLGRHTLGATPSSYGLPDYWTQVLVLFEVHRR
                     IRSKEPVGEAQLSLLSPLYRRLVEERWPAIAPAPVAG"
     gene            1929..2672
                     /locus_tag="GWQ54_RS20615"
     CDS             1929..2672
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="GWQ54_RS20615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_167160966.1"
                     /transl_table=11
                     /translation="MTTSTHWHSTASIADGFDAYDDLPERLIGYPAVFAALGIGTPDVR
                     TVLDYGCGPGKVATRVTEVCEADVVAADVSPRMLEIARICRPHPRIDYRQIDSGKLTFL
                     ADGSIDAAMSCYVFINVGELPLLHEIAAEIHRVLRPGARYAVLDTNPDTTGVRFSTFRN
                     GEPGRTYACGERRQVLLDQPGGGEPLELVDHHWPRQTYLDVLGEAGFTDLTVEEPLLTD
                     PSALPGAAPAETTHPPFLIVTGVKQ"
     gene            2669..3166
                     /locus_tag="GWQ54_RS38400"
     CDS             2669..3166
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018022529.1"
                     /locus_tag="GWQ54_RS38400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleoside 2-deoxyribosyltransferase"
                     /protein_id="WP_202520077.1"
                     /transl_table=11
                     /translation="MTTTTATESVQQTHSVFLGGPFKALVDSDGAMNAAARTRFEVLIE
                     RLEAEGYHVYNAHRRESWGAKFLTPDECTRLDYDEISASSVFVAIPGHPASPGTHIEIG
                     WASALGKPIVLLLEEGVDYAFLVRGLHTVADVTCLTIGDTDRLATEVVDAVNRLARAGA
                     NG"
     gene            complement(3302..3886)
                     /locus_tag="GWQ54_RS20625"
     CDS             complement(3302..3886)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015032372.1"
                     /locus_tag="GWQ54_RS20625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167160963.1"
                     /transl_table=11
                     /translation="MTALLPLLFLDVDGPLNPYAAKPHCRPVGYRTHRLRPEGWIAQHP
                     TSPRAYVKPLRVWLNPAHGPALLALADRFELVWATTWEADANEWIGPLLGLPYLPVVEW
                     PNLRETSPDGTFWKTPRLVKYAAGRPFAWVDDDIGPADHRFVAAHHSATALLRRTDPRL
                     GLLEPDFRALAAFADSPGPIDGAGLPAMPRA"
     gene            4111..4326
                     /locus_tag="GWQ54_RS20630"
     CDS             4111..4326
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GWQ54_RS20630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_167160961.1"
                     /transl_table=11
                     /translation="MTSDELHTRITQLEAQLARPTPPPIGGQVSIPLEPIRHHAYTGDG
                     GPCTTSLFGERCAEPVDHHEIHDQHP"
     gene            complement(4409..5431)
                     /locus_tag="GWQ54_RS20635"
     CDS             complement(4409..5431)
                     /NRPS_PKS="Domain: PKS_ER (83-330). E-value: 1.7e-22.
                     Score: 71.9. Matches aSDomain:
                     nrpspksdomains_GWQ54_RS20635_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177257.1"
                     /locus_tag="GWQ54_RS20635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_167160959.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-17, bitscore:
                     63.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNETALTVHQTARPHGFPTAEHFSFTESTIPDPAPGSALVENLYW
                     SVDPYHRELMDDVPGGFALHAPLEGRSIGRVIASRTPRLAEGEIVFHRHGWRTHAVVAP
                     DETRRLPRFDGVPLTAYLSTLGGTGLTAYVGLTRIARLQEGEDLFVSAAAGGVGTATGR
                     FARLLHAGRLVGSAGSAAKAAHLVREVGYDAVFDYHDGPADDLLGRVAPAGVDVFVDNV
                     GGEQLAAAVGSLREFGRIVRIGTISQYNTPGAPAPRFDYADIVEKSIRMEGFLVSNYRD
                     VQEELYAFAVPHLQSGRLALDETVIDGFEHIVDAFLGMLCGENTGKIIVRDHTQVPSAH
                     "
     aSDomain        complement(4442..5182)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GWQ54_RS20635_PKS_ER.1"
                     /evalue="1.70E-22"
                     /label="GWQ54_RS20635_PKS_ER.1"
                     /locus_tag="GWQ54_RS20635"
                     /protein_end="330"
                     /protein_start="83"
                     /score="71.9"
                     /tool="antismash"
                     /translation="LAEGEIVFHRHGWRTHAVVAPDETRRLPRFDGVPLTAYLSTLGGT
                     GLTAYVGLTRIARLQEGEDLFVSAAAGGVGTATGRFARLLHAGRLVGSAGSAAKAAHLV
                     REVGYDAVFDYHDGPADDLLGRVAPAGVDVFVDNVGGEQLAAAVGSLREFGRIVRIGTI
                     SQYNTPGAPAPRFDYADIVEKSIRMEGFLVSNYRDVQEELYAFAVPHLQSGRLALDETV
                     IDGFEHIVDAFLGMLCGENTGKIIV"
     gene            5541..6461
                     /locus_tag="GWQ54_RS20640"
     CDS             5541..6461
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321119.1"
                     /locus_tag="GWQ54_RS20640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_167161787.1"
                     /transl_table=11
                     /translation="MTGSDLVPQELRALVAVADTGGFSAAADALGLTQSAVSHSVRGSE
                     RKIGAVLFERGRAGARPTPAGDKAVAYARRVLRLLDVLTVEARGAARPDAAEGPLRIAA
                     FRSAALHLLPPALQRLRARHPGIEPRVRIVRELGRGTTGEVADGRADLAIATLGGSAPL
                     PSGLVAGELLTEPYALVHAKGQGTPRSLPLVDWAENCGSYTRRWWAAQDWIPKATIEAE
                     DDGAVLSLVSGGHGMAIMPALSLAGAPDSVGITDLGPGRPTRRVGFVTTSELARSAVVR
                     ALVRELRATAPEGVPHPNDLALQGR"
     gene            complement(6492..7148)
                     /locus_tag="GWQ54_RS20645"
     CDS             complement(6492..7148)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020113584.1"
                     /locus_tag="GWQ54_RS20645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WP_167160957.1"
                     /transl_table=11
                     /translation="MATLLHLDSSLFPAGASASRAVTDAFRKAWEAQHPQGTVVYRDLS
                     VDPVPHLDGLAASAAFVDPAAHTPEQAAAFAERMKLVTELEQADAVLIGAPMYNFTIPS
                     TLKAWLDQVVLMGRTAGPESIVKGLPITVVASRGGSYAPGTPREPFEYVQNYLGALLSE
                     MLGAEVDFIVPELTLAASNPAMSELIPLAEASREKALADAAEKAKSLAARVGSAA"
     misc_feature    complement(7217..7234)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            7248..7622
                     /locus_tag="GWQ54_RS20650"
     CDS             7248..7622
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529440.1"
                     /locus_tag="GWQ54_RS20650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_161244319.1"
                     /transl_table=11
                     /translation="MADQEERDSGQRHEPEACGRVGDGITQVFGLLGKRWTGLIVSALT
                     QGLDRFTDLRQAVPGISERMLADRLMELVAAGLVLREVDEGPPVRVSYRLTESGAALEP
                     ALTELAQWAEKYLLNGKGSC"
     gene            complement(7674..8564)
                     /locus_tag="GWQ54_RS20655"
     CDS             complement(7674..8564)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955215.1"
                     /locus_tag="GWQ54_RS20655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_167160955.1"
                     /transl_table=11
                     /translation="MTAPAPPASDASSPPDRPAVRDGTGPERVPRLWHELRAVHALVHR
                     DLLRLAAQPVHTGLMLVQPMLYLFILGGGLAALIPNSSLGGGYQTYLFPGVLMMTVQTP
                     AIMVGIRLITDRQSGYVRELLMAPVRRPTLLLGTCAGGTLVATVQGAVLLALVGAIGLP
                     YDPLLLLTLLVGMMLTSFTLTALALTLAVTLDRPEVFNMLLGLVMMPLLLLSGGFFPVG
                     NLPGWAHTLAAANPLAYGVDVLRRCIAARVPYRAAPTTVEWSGWQPPVLLEGTFLLTVG
                     ILALLWAAHRFGRPE"
     gene            complement(8561..9673)
                     /locus_tag="GWQ54_RS20660"
     CDS             complement(8561..9673)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845680.1"
                     /locus_tag="GWQ54_RS20660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_167160953.1"
                     /transl_table=11
                     /translation="MQPDTADEARTRATLPPTTAASPDLEPSAVQSAYAISTRGLVKSY
                     PGPDGVTTHAVHGLDLDVHRGETFAFLGPNGAGKSTTISLLCALARPTAGQATVAGVDV
                     IRQPDEVRRRVGMLFQQSALDSDLTAEQNLHIHARLYGLSRRHARLRATETLEKVGLAD
                     RRRSRVRTLSGGMRRRLELARGLLHAPRVLFLDEPTTGLDPHARAQIWEYLRALRDQHG
                     NTLFVTTHYLEEAENCDRLGIIDHGRLVAEGTPLALKAAIGDDRVALRTGDDAAARHVV
                     AGLAPEGRAITLDADGVSLRIPDGSTWIPRLCAALADQGIAVHAASATPPTLDDVFFHH
                     TGRSINAPPSHGTPTAMVPAATPAAIEEAP"
     gene            complement(9777..9932)
                     /locus_tag="GWQ54_RS20665"
     CDS             complement(9777..9932)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104907.1"
                     /locus_tag="GWQ54_RS20665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VenA family class IV lanthipeptide"
                     /protein_id="WP_167160951.1"
                     /transl_table=11
                     /translation="MENQDLEVLAHLHALPETDPIGVDEAQFGGTCACTGLLTLLNTVC
                     VGVSCA"
     gene            complement(10001..12673)
                     /gene="lanL"
                     /locus_tag="GWQ54_RS20670"
     CDS             complement(10001..12673)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523352.1"
                     /locus_tag="GWQ54_RS20670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_167160948.1"
                     /sec_met_domain="Pkinase (E-value: 4.9e-17, bitscore: 60.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.8e-45, bitscore:
                     154.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSHATEVDLEVLLRRILQATGMSERWTADVDEMWCRLVRPSGIR
                     RQQGWKLHVSATAASAPEVLVRALDVLLREESIFKFARSLEQVGALNSRATPRGSSGKF
                     ITVYPPSDDDAARLALELHNATAGLAGPRILSDQPYAPNSLVHYRYGAFVGRRRLSEHG
                     LLVWFMEDPDGNPVEDKRTGQYAPPSWAVSPFPASVPLPPQQDTAASSPVLLGGRFSVR
                     EAIRHTNKGGVYRGTDVTTGRAVVIKEARPHVEADASGGDVRDWLRAEATTLEKLKGTG
                     LAPEPVAMFETGGHLFLAQEEVPGVPLHTWVAERYRDVGSERYRADALAQVDRLVDLVD
                     AAHAQGWILRDFTPGNVMVRPDGELRLIDLELAVLEGDSMLPTTVGTPCFSAPERLVGA
                     PVSRTADYYSLGATVCFVLAGKVANLLTEEPATRPAQERFAEWLAACADVLRLPDALTD
                     VILGLTRDEPGERWTPAAAREALRKTNAVQPERLSTDTGRTEGPHDVTEIVIAGMVNHL
                     VDSMNPADDRRLWPVSTQAGETGPCTVQQGAAGVLTVLTRYFETTGDPRLPDLLATAGH
                     WMAARTDTASIRPGLHFGGRGTAWALYDAGRAIGDRELMDHAVALAVAPLESTPSYDIT
                     HGSAGSGLAAAHLWHRTGDPRLAELVVADADRLAAAARVEPPGVSWPVPAEAVSQEAGK
                     RYLGFAHGTAGIGCFLLTAAAISNRPEHMQLAVAAGESLVTHAVMVGAAAQWPAQATDV
                     PTAPYWCHGSAGIGTYLIRLWQATGDKRFADLAHQAARAVVERASRAALTQCHGLAGNG
                     DFLLDMAEATGDPAYRAMAEDLARLIGSERAHRNSHVVFPNEYGNVSTSWSDGTAGILA
                     FLLRTRHTGPRHWMVQQPG"
     misc_feature    complement(11873..11875)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(13208..13228)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.44"
                     /tool="antismash"
     gene            14157..14819
                     /locus_tag="GWQ54_RS20675"
     CDS             14157..14819
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240675.1"
                     /locus_tag="GWQ54_RS20675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="deoxynucleoside kinase"
                     /protein_id="WP_167160946.1"
                     /transl_table=11
                     /translation="MPVICVGGMIGIGKTSVAELLAKELGSAVFYESVEDNPILPLFYT
                     ASPEEIQAKRYPFLLQLYFLQTRFASIKEAYKQGDNVLDRSIYEDWYFAKVNHDLGRIS
                     SLEMQVYEGLLNEMMREIDGLPYRKAPDLMVYLKADFDTVLHRIGLRGRDFEQDESLVE
                     YYRTLWAGYDDWVHKHYSASDVLVVDMNHTDVVNNPEDAARVAQEVKAALAAAGPRN"
     gene            complement(14975..16087)
                     /locus_tag="GWQ54_RS20680"
     CDS             complement(14975..16087)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015780.4"
                     /locus_tag="GWQ54_RS20680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_167160944.1"
                     /sec_met_domain="Aminotran_5 (E-value: 5.9e-07, bitscore:
                     27.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLHSTYGLTRIINARGPYTPLGVSRSGEGVATAVAAALSEFFVM
                     VELQDVADRALARFAGAEAGTVVHCTASAITLAVAATMTGESAERIAALPDTTGMPRAV
                     VLPAGHAVDYGHSITQAVRLAGAVPVAVGTEEAYTLEDLENGLSRPDVVCLLLVSSRLV
                     RGAGAELSEAVAVAHRHGVPVVVDGAAQDFRVDELLRTGADLVTVSGQKYLGSPTAGLV
                     VGRAGPVAAVRAQERGIGRAMKASKEAVVGVLAALEARHGLDMEAWKRQQADKVAEFVA
                     RADALRGVTAAPVPDPTGLPFERARLTVDPAVSRMDAAALESALRSGSPSIWVMPGGRP
                     GAEEVLLELVPLTPAEIDAVLVRLAELLPA"
     gene            complement(16304..18031)
                     /locus_tag="GWQ54_RS20685"
     CDS             complement(16304..18031)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529148.1"
                     /locus_tag="GWQ54_RS20685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_167160942.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.6e-47, bitscore:
                     159.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.2e-38, bitscore:
                     129.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTVARLFVDALEELGVRQVFGVVGDALNPLTDAIRTSDALSWV
                     GCRHEEAAAFAAGAQSQLTDTLGVCMGTVGPGSVHLLNGLYDAAKSGTPVLAIAGQVPR
                     SEVGTDYFQEVDNDLLFKDVAVFRATVTSPEQLPALLEVAVRTAIGRRGVAVLTIPGDI
                     GDQELPNDRPLRLSVARSENRPDDPALDEAARLIDEGGNVTLLVGRGSRTSRDDVLALA
                     DRLAAPMVLTLKAKEGFEGDNPFQVGQTGLIGNPAAAHAMDHADTLVLLGTDFPYREWY
                     PEGKKVVQVDRVAEHIGRRVPVDVALAADVGPTVRGLLERVAPREDRKHLDSAREKFTH
                     WQDGQRRLAAPGHDKGLIGKVRSAFDNRDHLVRPEALAAAVDAAADDDAVFTSDTGMAT
                     VWLSRFVEMRGSRRLIGSYNLGSMANAMPQAIGAQFLDRDRQTIAFCGDGGLSMLLGDL
                     MTIRTERLPVKLVVFDNRRLGMVKLEQEQAGLPEFGTVLDNPNFAAVAEALGIKGIRVE
                     RAEDLAEAIERTFAEPGPVLLDVLTNPDEIAVPAKPTVQQGWGFAIAKVRENLRSTGS"
     gene            complement(18170..19756)
                     /locus_tag="GWQ54_RS20690"
     CDS             complement(18170..19756)
                     /EC_number="1.4.-.-"
                     /GO_function="GO:0015930 - glutamate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016638 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors [Evidence IEA]"
                     /GO_process="GO:0006537 - glutamate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529147.1"
                     /locus_tag="GWQ54_RS20690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FMN-binding glutamate synthase family protein"
                     /protein_id="WP_167160940.1"
                     /transl_table=11
                     /translation="MVRFGAVALLIVCAAAAVTSAFVVSPWWWFAGALLGAIALLGCYD
                     LLQRRHSVLRNYPVLGHARFLLEAIRPELQQYFVERNYDGRPYDRDTRSIVYERAKGVD
                     AEEPFGSERDMYSRGYEFLVPSMRPVDMPKEAPRVRVGGPDCTRPYDMALLNVSAMSFG
                     SLSGNAVLALNTGAARGGFAHDTGEGGLSEYHLRPGGDIIWEIGTGYFGCRTKDGDFDP
                     DKFREKAAHPAVKCVSLKLSQGAKPGMGGVLPGDKVNSEIAQVRGVPEGKTVVSPPYHR
                     VFSTPREMVRFLARMRELADGKPVGFKLCPGSRVQFLAVCKAMIAENITPDFIVVDGAE
                     GGTGAAPLEFADHLGMPLTEGLITVHNALVGAGLRDRIRIGASGKVATGSDIVKRLAMG
                     ADWTNAARAMMFAVGCIQAQRCHTNRCPTGVTTQDPRRARALDVADKSERVERFQEATV
                     SSALKIMAAMGVSDPGDLGPHLLRRRATDGDDFRSYAELYEWLKPGELTLDPPAGWGAD
                     WKAADPDSFTG"
     misc_feature    complement(19782..19793)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(20081..20095)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            20173..20913
                     /locus_tag="GWQ54_RS20695"
     CDS             20173..20913
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152148.1"
                     /locus_tag="GWQ54_RS20695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_167160939.1"
                     /transl_table=11
                     /translation="MRFTSEQHLEDGVRERHFTLGGIPGILWTPASATPTTPAPLILLG
                     HPPLGLRKMHPRLVTRARHSAADGFASATIELPGSGDRPRLPAVEQSRADLRRALAAGE
                     PVSDEVVDAVVLPLVDRAVPEWQTALDAVLSLPEIGGPVGYSGGVISIGIRLALVEPRI
                     SAAVLFAGSFVPRAVFEEARQITIPLHVLLQWDDEGNDRQAALDLFDAFGSQDKSLHAN
                     MGGHTGVPQFAGEAAAQFFTRHLK"
     gene            complement(21165..22421)
                     /locus_tag="GWQ54_RS20700"
     CDS             complement(21165..22421)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981693.1"
                     /locus_tag="GWQ54_RS20700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_167160937.1"
                     /transl_table=11
                     /translation="MTTEPTARSLPSEPLGDTHLRRLIVGQGLAAVVDALFLIWLTLFV
                     LKLSEPGMTTGFVLVAVALPRAALLLPAGVLVDRVGPARIAAGAAWLRVAVLLALGALV
                     TLTSPSVATVALLAGLLGAADAAYFPAALALLPAVVPTEKLARVNALVQGAESGGDLVG
                     PAVAAGVIAVVGFDATLGGIVALAALAAVALSMPIRAVRRGERAGGAAGPDEVDGERVS
                     TARALGAGLRYAWREPVVRGMLAAIALINITVVGPVLVGGAVLADQRLGGAGSLGIVLS
                     GFGAGSLAGSLVAGWRPPARRGWTVVGGVAAIGAGMAGLAAVTDVVAATAVVSLIGLGS
                     AFLGVVVVATLQERVPQRLLGRVLSLVVLATVAFDPFSYLLAGVLVPFGTATLFLVCGG
                     AVLACAGLVATSPAIRSLR"
ORIGIN
        1 gcgacggcga cctgcacgac ggcgagtccg accccgcccg ccccgatgac cacgagccgc
       61 tccccgggga cagtgcgggc caccgagcgg acgacacgga cggcggtcgt ccctgagcag
      121 cccagaaccg cggcttcgtc gaaaggcacc gtgtccgcga tccgaaccag tgagcccgcg
      181 tgcgccaggt agtactcgca caagccgccg tcggagtcga agccgacctt cgccgccggg
      241 tcggggcaga ggttctccga gccgtccgca caccacccgc agtgcccgca cccctggtag
      301 tagtaggcca ggacccggtc gccgacccga cagtcggctc cgtcccccac ctcggcgact
      361 tcgccggcga tctcgtgccc gagcacgagg ggcagcggcg gggtgagcgc cgaaccgtcg
      421 gccagatgca gatcggtgtg gcagagcccg gccgcccgca cccggatgag cgcctggccg
      481 ggcgcgggta cggggcgggg acggggttcg atctccaatg gcttgcccag tgcgttcagt
      541 accgcagccg acatcacacc gcttggcatc gcgacctccg tgaaccgccc gccgggaacc
      601 cgacggcctg cggaacaaga tcctcacagg cgcggagcag gcacggcgcc acggccgcgc
      661 aacacgtacc aggattgacg tttctcttgc ctcccacctg cggtgatgtc ctgcgcaccg
      721 cgcggagatt cacccgttgg acgggctccg agtagctggt acggccagca gaggtccgac
      781 cgtctgggcc gtagaaccta ctctgacctg ctgtttcccc gatcctccgc agcacgggcg
      841 agcaggccgg aggggacggg tccagtacgg cgcccattac gttccgaacc aagtggatca
      901 ccggcagcag agagcgaccc tgtggacttc gaaacctttc atgatgccta tccccgcatg
      961 ctgcggtggc tgatcgagga gcccgcctac cgcaacgcgc cgcgcgggta cgccagccgc
     1021 gagcagctcg gagtcagctt ccggatcgcg cgggcggacc agcgggtgcc gttcgttccg
     1081 gcccggcggc tgaacatcgt cttcaacttc gccgaggccc tctggtactt ggcaggccgg
     1141 gacgacctcg acttcatcgc gtactacgcg cccagcatcc gcaagtactc cgccgacggg
     1201 caccggctga ccggcaccgc ctacgggcgt gcgctgttcg gcgccgccga gggacggccc
     1261 gaccagtggc cggccgtcgt ggagaccctg cgcgaggacc cggattccaa gcgggccgtc
     1321 atccagatct tccgcggcga ggagctgcag gtgtccggca acccggatgt gtcctgcacc
     1381 ctgggcctgc agttcctgct gcgcgaaggg gcgctgcacg cggtgggatt catgcgcgcc
     1441 aacgacgtgt accggggcat gagcagcgac gtcttctcgt tcacgttcct ccaggagatg
     1501 ctcgcccgcg aactcggcgt cccggtcggc agttacgtgc accaggtcgg ttccctccac
     1561 ctctacgacc ccgaccactc aagggccctg gaggtccttg ccgacccggc cgccgacgag
     1621 ccgtcggcct ggagcttccc cctcatgccg gagggcgaca actggccctg ggtgcgcgag
     1681 gtgttggccg tcgaggagca gctgcggctc ggccgtcaca cgctcggcgc caccccttcc
     1741 tcgtacgggc tgcccgacta ctggacgcag gtcctcgtcc tcttcgaggt ccaccggcgc
     1801 atccgtagca aggagcccgt cggggaagcg caactgtcgt tgctgtcacc gctctatcgc
     1861 cgcctcgtcg aggagcgctg gcctgccatc gcccccgccc ccgtagcggg ctgaaaggga
     1921 aaccgatcat gacaacgagc acgcactggc actccaccgc ctcgatcgcc gacggcttcg
     1981 acgcctatga cgacctgccg gagcgcctca tcggctaccc ggccgtcttc gccgccctcg
     2041 gcatcgggac acccgacgtc cgcacggtcc tggactacgg ctgcggcccc gggaaggtcg
     2101 cgacccgcgt caccgaggtc tgcgaggcgg acgtcgtggc ggccgacgtg tccccgcgca
     2161 tgctggagat cgcccgcatc tgccgaccgc acccgcgcat cgactaccgc cagatcgaca
     2221 gcgggaagct caccttcctc gccgacggct ccatcgacgc ggccatgtcc tgctacgtgt
     2281 tcatcaacgt cggtgaactc ccgctcctgc acgagatcgc cgcagagatc caccgcgtac
     2341 tgcggcccgg cgcccgctac gccgtcctcg acaccaatcc cgacaccaca ggcgtccgct
     2401 tctccacctt ccgcaacggc gagccgggcc gcacctacgc ctgcggtgaa cggcgccagg
     2461 tcctcctgga ccagcccggc ggcggcgaac cgctggaact cgtcgatcac cactggccgc
     2521 gtcagaccta cctcgacgtc ctcggcgagg ccggcttcac cgacctcact gtcgaggagc
     2581 cgctcctcac cgacccctcg gccctgcccg gtgcggcgcc ggccgagacc acccaccctc
     2641 cgttcctcat cgtcacggga gtcaagcagt gaccaccact accgccaccg agtccgttca
     2701 gcagacccac agcgtgttcc tcgggggccc tttcaaggcc ctcgtcgact ccgacggggc
     2761 catgaacgcc gcggcccgca ctcgcttcga ggtcctcatc gagcgcctgg aagcggaggg
     2821 ttaccacgtc tacaacgccc accgccgcga gtcctggggc gcaaagttcc tcacccccga
     2881 cgagtgcacc cgcctggact acgacgaaat ctccgccagc agcgtcttcg tcgccatccc
     2941 gggccacccc gcctcccccg gcacccacat cgagatcggc tgggcgtccg ccctgggcaa
     3001 gccgatcgtc ctcctcctgg aagagggagt cgactacgcc ttcctcgtcc gcggcctcca
     3061 cacggtcgcc gatgtcacct gcctcaccat cggcgacacc gaccgcctgg ccaccgaagt
     3121 cgtcgacgcg gtgaaccgcc tggcccgagc cggtgccaac ggctgacctc cgcttgcccg
     3181 ggggcgcgta ccgaccttgc acccggtgtc tccccatgcg gtccctgacc ggcccacggc
     3241 tgtccgaacg tgggtcggca cggggttggc ttgaacgcct ggtcagaccg tggggggccg
     3301 ctcaggctcg cggcatggcg ggcagaccgg cgccgtcaat cgggcccggg ctgtcggcga
     3361 atgcggcgag tgccctgaaa tcgggttcca gcaggccgag tcgagggtct gtccggcgga
     3421 gcaatgcggt ggccgagtgg tgggcggcga cgaaccgatg gtcggccggt ccgatgtcgt
     3481 cgtcgaccca ggcgaagggg cgtcctgcgg cgtacttcac caggcggggc gtcttccaga
     3541 acgtcccgtc cggtgaggtc tcgcgcaggt tgggccattc gaccacgggc agatacggaa
     3601 gtcccaggag cgggcctatc cattcattgg cgtcagcctc ccaggtcgtg gcccacacca
     3661 gctcgaatcg gtccgcgagc gccagaagag cgggtccgtg cgcggggttg agccagacgc
     3721 gcagcggttt cacatacgcc ctggggctcg tcggatgctg agcgatccac ccttcgggcc
     3781 ggagtcgatg ggtccgatag ccgacgggcc ggcagtgggg cttggccgcg tacgggttca
     3841 gcgggccgtc cacgtcgagg aacagcagcg gcagcagggc ggtcatcagg agccccctcc
     3901 gtccggtcgc gggcggttgg tgtgtccaaa ccctaccggc acaagccgga caccctcttg
     3961 ctgatttccg accccagccg tcacggcccc gccgaccgga tcaacacccc cgcatcaggc
     4021 cgcgcaccat ctcgatgaca cacttgaggg accgactccg gctgaacggg tagggacatc
     4081 gaacggaccg cgacagatgg agaagtccct gtgaccagcg atgagctgca tacccgcatc
     4141 acccagctgg aggcgcagct cgcgcggccg acaccgccgc cgatcggcgg acaggtcagc
     4201 atcccgctcg aaccgatccg ccaccacgcc tacaccggcg acggcggccc ctgcaccacc
     4261 agcctcttcg gcgagcggtg cgccgaaccc gtcgaccacc acgagatcca cgaccaacac
     4321 ccctgaacac cggggcaggt cggatacgcg acgctcacgg tgcccgtgcc gactcaacgg
     4381 gcgggatggg ttccaagacc cgtcggagtc agtgcgcgga cgggacttgc gtatggtcgc
     4441 gcacaatgat cttgccggtg ttctcgccgc acagcatccc caggaacgcg tccacgatgt
     4501 gctcgaagcc gtcaatgacg gtctcgtcca gggcgagccg accgctctgc agatgcggga
     4561 ccgcgaatgc gtacaactcc tcttgtacgt cacggtagtt gctgaccagg aagccctcca
     4621 tgcggatgct cttctccacg atgtccgcgt agtcgaagcg cggcgccggc gcaccggggg
     4681 tgttgtactg gctgatcgtg ccgatgcgga cgatgcgccc gaattcgcgc agcgatccca
     4741 ccgccgcggc cagttgctcg ccgcccacgt tgtcgacgaa cacgtcgacg ccggccggag
     4801 ccaccctgcc caacaggtcg tccgcgggcc cgtcgtggta gtcgaagacg gcgtcgtagc
     4861 cgacctcccg cacgaggtgg gccgccttcg ccgccgagcc cgcgctgccc acgagccgtc
     4921 cggcgtggag cagcctggcg aaccgcccgg tcgccgtgcc gaccccgccc gcggcggccg
     4981 acacgaacag gtcctccccc tcctggagtc gggcgatccg ggtcaggccc acataggcgg
     5041 tcaggccggt gccgccgagg gtgctcaagt acgcggtcag gggcaccccg tcgaagcggg
     5101 gcagccgccg ggtctcgtca ggtgcgacca cggcgtgggt acgccagccg tgccggtgga
     5161 acacgatttc gccctcggcc agtcggggcg tgcgcgaggc gatcacccgc ccgatggagc
     5221 ggccctccag cggcgcgtgg agcgcgaagc ctccgggcac gtcgtccatc agctcgcggt
     5281 gataggggtc gaccgaccag tagaggtttt ccacgagcgc gctgccgggg gcgggatcgg
     5341 gaatcgtgga ctccgtgaag gagaaatgtt cggcggtggg gaagccgtgg gggcgggcgg
     5401 tctggtgcac ggtgagcgcg gtctcgttca tgcccggaac ctagggcggg aatggccctc
     5461 gggtgcagcc ggttgggctc atgcgacgca ccgttccatg agcacttctc atacatcgag
     5521 gtgagcgccc cgtggcccgc atgaccggct ccgatctcgt cccgcaggaa ctgcgtgctc
     5581 tggtggcggt cgcggacacc gggggcttct cggccgcggc cgacgcactc ggcctgacgc
     5641 agtccgcggt ctcccactcg gttcgcggca gcgagcgcaa gatcggcgcc gtcctcttcg
     5701 aacgcggtcg cgccggtgcc cggccaactc ccgctggaga caaggccgtt gcgtacgcgc
     5761 gtcgtgtcct gcgcctgctg gacgtcctga ccgtcgaggc gcgcggcgcc gcgcggcccg
     5821 atgcggcgga ggggccgctc cgcatcgccg ccttccgcag cgcggccctc catctgctgc
     5881 cgcccgcgct gcagcggctg cgcgcgcggc atcccgggat cgagccgcgg gtgcggatcg
     5941 tacgcgagct cgggcgcggc accaccggcg aagtggccga cggcagggcc gacctagcca
     6001 tcgcgacgct cggcggctcc gcgccgctcc cctcgggcct ggtcgccggc gaactcctga
     6061 ccgagcccta tgccctggtg cacgcgaagg gccagggcac tccgcgctcg ctgccgctgg
     6121 tcgactgggc ggagaactgc ggttcgtaca cccgtcgttg gtgggccgca caggactgga
     6181 tcccgaaggc aaccatcgag gcggaggacg acggagcagt gctctccctt gtgagcggtg
     6241 gccatggaat ggcgatcatg cccgcgctct ccctggccgg agcgccggac tcggtcggga
     6301 tcaccgacct cggcccgggg cgcccgacgc gccgggtcgg cttcgtgacc acctccgagc
     6361 tggcccggtc cgccgtcgtg cgcgccctgg tgagggaact ccgggccacc gcccccgagg
     6421 gcgtccccca tcccaacgac cttgctctgc aaggccgttg agacatgggc cttgctggtg
     6481 acgaggcgat gtcaggcggc ggaaccgacc ctggcggcca gcgacttggc cttctcggcc
     6541 gcgtccgcga gagccttctc gcgggatgcc tccgcgaggg ggatcagctc ggacatcgcc
     6601 gggttcgaag cggccagcgt cagctccggg acgatgaagt cgacctcggc gcccagcatt
     6661 tcggaaagga gcgcgcccag gtagttctgc acgtactcga agggctcgcg cggggtgccc
     6721 ggagcgtacg agccgccgcg gctggcgacg accgtgatcg gcagaccctt gacgatcgat
     6781 tcgggacccg cggtgcggcc catcaggacg acctggtcga gccacgcctt gagggtcgag
     6841 ggaatcgtga agttgtacat cggcgcgcct atcaggaccg cgtcggcctg ctcgagctcc
     6901 gtgaccagct tcatgcgctc ggcgaaggcg gccgcctgct ccggggtgtg cgcggcaggg
     6961 tcgacgaacg cggcggaggc ggcaagaccg tccaggtgcg ggacggggtc gacggacagg
     7021 tcgcgataga cgaccgtgcc ctgggggtgc tgagcctccc aggccttgcg gaaggcatcc
     7081 gtcaccgcgc gggatgcgga ggccccggcg gggaacaggg acgagtcgag gtgcagcagg
     7141 gtggccatga agatctcccg aatggtggca cttttcgtag gccactagtg atagcacagc
     7201 tacttacttt ttttcatccc ctcacaagag ggtagtagtc tgaggccatg gcggaccagg
     7261 aagagcgcga cagcgggcag cggcacgagc cggaagcctg cggccgggtg ggcgacggca
     7321 tcacgcaggt cttcgggctg ctcggcaagc ggtggacggg gctgatcgtg tccgccctca
     7381 cccaggggct cgaccgtttc acggatctcc gccaggccgt cccgggcatc agcgagcgca
     7441 tgctcgcgga tcggctgatg gaactcgtgg ctgcggggct cgtcctgcgc gaggtggacg
     7501 agggaccacc ggtccgggtc tcctaccgcc tcaccgaatc gggcgccgca ctggaaccgg
     7561 ccctcacgga actggcccag tgggccgaga agtacctgct caacggcaag ggcagctgct
     7621 gaatacgccc ccgcccggcg tggcagaccc gctcccccga gccccgcggt gattcattcg
     7681 gggcggccga accggtgggc cgcccagagc agggccagga ttccgacggt cagcaggaag
     7741 gtgccctcca ggagcacggg gggctgccac ccggaccact cgacagttgt gggggccgcc
     7801 cggtacggga cccgtgcggc gatgcagcgg cggagcacgt ccaccccgta ggccagggga
     7861 ttggccgcgg ccagcgtgtg ggcccagccc ggcaggttcc cgaccgggaa gaagccgccg
     7921 gaaaggagca gcagcggcat catcaccagg ccgagcagca tgttgaagac ctctggccgg
     7981 tccagggtca cggccagggt cagcgcgagg gccgtgaggg tgaaggaggt cagcatcatg
     8041 ccgacgagga gcgtcagcag caggagcggg tcgtagggga ggccgatcgc accgaccagg
     8101 gcgaggagta cggctccctg caccgtggcg acgagggtgc cgccggcgca ggtgccgagg
     8161 agcagggtgg gccggcggac gggtgccatc aggagttcac gcacataacc gctctgccgg
     8221 tcggtgatca gacggatgcc gaccatgatg gccggagtct ggaccgtcat catcagcacg
     8281 cccgggaaga ggtacgtctg gtagccgcct cccagcgagg agttggggat cagggcggcc
     8341 agaccgccgc ccaggatgaa gaggtagagc atcggctgga ccagcatcag gccggtgtgg
     8401 acgggctggg ccgccaggcg cagcaggtcg cggtggacca gcgcgtggac ggcgcgcagt
     8461 tcgtgccaca ggcggggcac ccgctcgggg ccggtgccgt cgcggaccgc gggccggtcg
     8521 ggtggggagg aggcgtccga ggccggtgga gcgggtgcgg tcatggggcc tcctcgatgg
     8581 ccgccggggt ggcggcggga accatggcgg tcggtgtccc gtgggacggc ggggcgttga
     8641 tgctgcgacc ggtgtggtgg aagaacacgt cgtcgagtgt cggcggggtg gcggaagcgg
     8701 cgtgcaccgc gatgccctgg tccgcaagtg ccgcgcacag gcggggaatc caggtgcttc
     8761 cgtcggggat gcgcagcgat acgccgtcgg cgtccagggt gatggcgcgc ccctccggcg
     8821 cgagcccggc gacgacgtgc cgggccgccg cgtcgtcgcc cgtgcgcaat gccacccggt
     8881 cgtcgccgat cgcggccttc agcgccaggg gcgtgccctc ggcgacgagc cggccgtggt
     8941 cgatgatgcc gagacggtcg cagttctccg cctcctccag gtagtgggtg gtgacgaaga
     9001 gcgtgttgcc gtgctggtcg cgcagcgcac gcaggtactc ccagatctgg gcacgggcat
     9061 gcgggtcgag tccggtggtc ggctcgtcga ggaacagcac ccggggggcg tggagcaggc
     9121 cccgggcgag ttccagtcgg cgccgcatcc ctccggacaa ggtgcgtacc cgggaccgcc
     9181 gccggtcggc aaggcccacc ttctccagcg tctcggtggc acgcaggcgg gcatggcggc
     9241 ggctcagtcc gtagaggcgt gcgtggatgt gcaggttctg ttcggccgtc agatccgagt
     9301 ccagggcgct ctgttggaag agcatgccga ccctgcgccg cacctcgtcc ggctgcctga
     9361 tcacatcgac gcccgcaacc gtggcctgtc ccgccgtggg ccgggccaga gcgcacagca
     9421 gggagatggt ggtggacttc cccgcgccgt tggggccgag gaaggcgaag gtttcacccc
     9481 ggtgcacgtc gaggtccagg ccgtgaacgg cgtgggtggt gacgccgtcc ggacccgggt
     9541 agctcttgac cagaccgcgc gtgctgatgg cgtacgccga ctggacggcg gacggctcca
     9601 ggtccgggga cgcggcggtg gtcggcggca gggtcgctcg ggtgcgggcc tcgtcggcgg
     9661 tgtccggctg catggtcgcg tcctcgtcta cgggggtggc tgccgcgggc ctgcccgcca
     9721 gcggtcgcgg ctccggccgg tggctgcgaa ggcaaccacc ggccggaggt cttggactag
     9781 gcgcaactga cgccgacgca cacggtgttg agcagggtca gcagaccagt acacgcacag
     9841 gtcccgccga actgtgcctc gtccacgccg atcgggtcgg tctccggaag ggcgtgcagg
     9901 tgcgcaagaa cttcaaggtc ttggttctcc atgactttct ccttctctgt gaggtgctcg
     9961 atgatgtgac gacagggacg atggtgcgca tccctgtcgc tcagcccggc tgctggacca
    10021 tccagtgccg ggggcctgtg tggcgggtcc tgagcaggaa cgccaggatt cccgcggttc
    10081 cgtcgctcca gctcgtcgag acgttcccgt actcgttggg gaagacgacg tggctgttgc
    10141 ggtgggctcg ttcggaaccg atgagtcggg ccaggtcttc ggccatcgcg cggtaggcgg
    10201 gatcgccggt ggcctcggcc atgtcgagga ggaagtcgcc gttgccggcg agcccgtggc
    10261 actgggtgag agcggcgcgg gaagcgcgct ccacgactgc tcgtgcggcc tggtgggcaa
    10321 ggtcggcgaa ccgcttgtcc ccggtcgcct gccagaggcg gatcaggtac gtgccgatgc
    10381 ccgccgaacc gtggcaccag tacggggccg tgggcacgtc cgtggcctgg gccggccact
    10441 gggccgccgc gccgaccatc acggcgtggg tcaccaggga ctctccggcc gccacggcca
    10501 gctgcatgtg ttcgggccgg ttggagatgg ctgccgcggt gaggaggaag cagccgatgc
    10561 cggccgttcc gtgcgcgaag ccgagatagc gtttgccggc ctcctgggac acggcttccg
    10621 ccggtacggg ccagctcaca ccgggcggct ccacccgtgc cgcggcagcc agccggtcgg
    10681 cgtcggcgac gaccagttcg gccaggcgcg ggtcgcctgt ccggtgccac aggtgggcgg
    10741 cggcgagtcc gctgcccgcc gagccgtggg tgatgtcgta gctgggtgtc gactccagcg
    10801 gggccacggc cagggccacc gcgtggtcca tgagttcacg atccccgata gcgcgtccgg
    10861 cgtcgtagag cgcccaggcg gttcctcggc cgccgaagtg caggcccgga cggatggagg
    10921 cggtatcggt gcgggcggcc atccagtggc ccgcggtggc gaggaggtcc ggcaggcgtg
    10981 ggtcgccggt ggtctcgaag taccgggtca ggacggtcag cacccctgcc gcaccttgct
    11041 ggacggtgca ggggccggtc tctcccgcct gggtggacac gggccacagt cgacggtcgt
    11101 cggccgggtt catcgaatcg acgaggtggt tcaccatccc ggcgatcacg atctccgtga
    11161 cgtcatgcgg cccttcggta cgtcccgtgt cggtggagag gcgctccggc tgaacagcgt
    11221 tcgtcttacg cagagcctcg cgcgccgcgg ccggggtcca tcgctcgccg ggttcgtccc
    11281 tcgtcagccc gaggatcacg tcggtcaggg cgtccggcag gcgcagcacg tcggcacagg
    11341 ccgcgagcca ctcggcgaac cgctcctgcg cgggcctggt ggccggctcc tccgtgagca
    11401 ggttcgccac cttgcccgcg agtacgaagc acacggtggc gccgaggctg tagtagtcgg
    11461 ccgtccgcga cacgggagcg ccgaccaggc gctcgggggc actgaagcag ggggtcccca
    11521 ccgtggtcgg gagcatgctg tcgccctcca ggacggcgag ctccaggtcg atgaggcgca
    11581 gttcgccgtc ggggcggacc atgacattgc cgggggtgaa gtccctcagg atccatcctt
    11641 gggcgtgggc cgcgtcgacc aggtccacca ggcgatcgac ctgggcgagc gcgtccgctc
    11701 ggtagcgttc gctcccgacg tcccggtaac gctcggcgac ccaggtgtgc aggggcacgc
    11761 ccggtacttc ttcctgggcg aggaacaggt gcccgcccgt ctcgaacatc gcgaccggct
    11821 cgggggcaag gccggtgccc ttgagtttct ccagcgtcgt ggcctcggcc cgtaaccagt
    11881 cacggacgtc gccgcccgag gcatcggcct cgacgtgcgg ccgggcttcc ttgatcacca
    11941 ccgctctgcc cgtggtgacg tccgtgcccc ggtagacgcc ccccttgttg gtgtgccgga
    12001 tcgcttcccg taccgagaac cggccgccga gcagcaccgg gctgctcgcc gcggtgtcct
    12061 gctgcggcgg gagcggcacc gaggcgggga acgggctcac cgcccatgac ggcggcgcat
    12121 actgaccggt tcgtttgtcc tcgacggggt tgccgtcggg gtcctccatg aaccacacca
    12181 gcagaccgtg ctccgacagc ctgcgccggc cgacgaaggc tccgtagcgg tagtggacca
    12241 gactgttcgg ggcgtagggc tggtccgaga ggatgcgcgg gccggccagt cccgcggtgg
    12301 cgttgtgcag ttcgagcgcc agtcgggccg cgtcatcgtc ggagggcggg taaacggtaa
    12361 tgaacttgcc ggaactcccc cggggcgtag cccgtgagtt gagcgcgccc acctgttcga
    12421 gcgaccgggc gaacttgaat atcgactcct cccgcagcag cacgtccaaa gccctcacca
    12481 ggacttccgg tgccgacgcg gccgtcgcgg acacatgaag tttccagccc tgctgacgac
    12541 gaataccaga ggggcgcaca aggcggcacc acatctcgtc cacatcggcc gtccaacgct
    12601 cgctcatgcc tgtggcctgc agaatccgac ggagcagaac ttcgagatcg acctcggtcg
    12661 cgtgactcgt catgcgcgtc cctctcaacg gtgaaaaccg ctggtggaat atgccttcgg
    12721 taaggagaaa ggtatagctt gcaaccgccg caagatactt gatgcagctg gcgcacggtg
    12781 gcactggggc aatacatggc gcagtccggc gcaaatggag gcgcacggcc gtcgacagac
    12841 ggaaataatc catttgttcg acgtttcggc cgcggccaca cgcagtacag gaaatgacga
    12901 gttcaggatc atttctccac ttcgcagcgc ttgttccgtc aaaagagcca ttgatcgatg
    12961 gaccgggcac caaacccgca ggtcaggcca gtttccatgc actgtccggc aaggagcacc
    13021 ggtcctccgt cccgcgcccc ggtccggatc aagcggcgcc ttgatcagca gcacggtccg
    13081 gttgcggcac gagccagggg cacgtcccgc cgacccagct tcgccctcgc caggcacccg
    13141 gtaaagggca caatcccgcc acccttccca ccgccgaaag gggcagtcca agccacctgc
    13201 acaaccatga tcgtcagccc gattcaagcc ttcactaaag atattgaatc gtcaactcat
    13261 tcgacgcgtt tcattaatgg cgaatgagcc gggctcatgc agaactgctt cgacgtcaca
    13321 cgcagaacaa acggaacaaa ggaaatacaa atcaacccgt gaaacaattc gatgcggcat
    13381 taccgcaggc gacccggatg gttgagctgc atcgtcgaga agctgagcgt cgcggtcacc
    13441 ccttgcggcg accgcccgct ccgcgcagat acgaagggtg tcatggaatt ccgcacgctc
    13501 ctcgcgcgcc gccaggtcgt gaatcgacca ccgaaggttc tcagtcccct cggggataat
    13561 gccgcgtgga gaacagcagt tgcccatggg cctctgtctt gcgagcgtga cttgcctcgt
    13621 ggtcggctgt gggagacgag tcggctccgg tggcagtcgg gaggtcggtc agcgcggtga
    13681 tgtgcgcgcc gggcgcatcg cgcccccggc ggcagccgcg cgccgtcccg gggtgaatcc
    13741 ggccaccgcg tgcgccggtt cacctcaggg agcagggccg attagcagcg gccgcttctc
    13801 gtcaggcgct cggcggcttc gatgccgccg ggaccaggca gcgccgaccc ggtcggacgg
    13861 atcgagcggg tgcgtcgcgc ggacgggtcg agcggacgcg acccgccggt cgcactcccc
    13921 cggtgtctgc tctcgggcca ctcgctttgc ttcccacccc ccgtgcgggc ggggcgaggg
    13981 acttcgtcat ttatgcttca gggcggcctc ggggtggcgg gtctgaacag tggccacgtg
    14041 acggccgagc tgaacgttct tggggagtcg actctccgcc gacacgcgtc ttcgtcggtg
    14101 cgggacgcgc agcccggccc gcccgcgagc agagatcccc cggggagaag tgaggaatgc
    14161 cagtgatctg cgtcggaggc atgatcggga tcggcaagac gagcgttgcc gaactgctcg
    14221 cgaaggagct gggcagcgcg gtcttctacg agagcgtgga agacaacccg atccttccgc
    14281 tcttctacac ggcaagcccc gaggagatcc aggcgaagcg ctatcccttc ctcctccagc
    14341 tctacttcct gcagacgcgg ttcgcctcga tcaaggaggc gtacaagcag ggcgacaacg
    14401 tcctggaccg gtccatctac gaggactggt acttcgccaa ggtcaatcac gacctgggcc
    14461 gcatcagttc cctggagatg caggtctacg agggcctgct caacgagatg atgcgcgaga
    14521 tcgacggcct gccgtaccgc aaggcgcccg acctcatggt ctacctcaag gccgacttcg
    14581 acaccgtgct gcaccgcatc gggctgcggg gccgcgactt cgagcaggac gaaagtctcg
    14641 tcgagtacta ccggacgctg tgggccggct acgacgactg ggtgcacaag cactattccg
    14701 cgagtgacgt cctcgtcgtc gacatgaacc acaccgatgt ggtgaacaac cccgaggacg
    14761 cggctcgcgt ggcgcaagag gtcaaggccg ccctcgcggc ggccggcccc cggaactgaa
    14821 cccgttccca agcccagcga tacccgctcg tcgcccgcgc ccgccgcacc gcccctggac
    14881 gtagtccggg gtcgcggcag gcgcgccctc gcgttccgca atgtcgcggc cggtccacga
    14941 acgccctgga gtccgcccct cgcggaccag cccgtcaggc gggaaggagt tccgccagcc
    15001 ggacgaggac ggcgtcgatt tcggccggtg tcaggggcac gagttcgagc aacacctcct
    15061 ccgcgccggg ccgaccgccc ggcatgaccc agatcgatgg tgagcccgac cgcagcgcgc
    15121 tctccagggc cgcggcgtcc atgcgcgata cggcggggtc caccgtgagc cgagcgcgtt
    15181 cgaagggcag cccggtcggg tcggggacgg gcgcggcggt gactccccga agggcatcgg
    15241 cccgcgcgac gaactccgcc accttgtccg cctgttgcct cttccaggcc tccatgtcca
    15301 gtccgtgtcg cgcctccagc gcggcgagga ctccgacgac ggcctccttg ctcgccttca
    15361 tcgcacggcc gataccccgt tcctgcgccc gcacagccgc caccggaccc gctcggccca
    15421 ccacgaggcc ggcggtcggc gatcccaggt acttctgccc gctgacggtc accaagtccg
    15481 cacccgtacg cagcagttca tcgacgcgga agtcctgggc ggcgccgtcg acgacgacgg
    15541 gtaccccgtg gcggtgcgcg accgccaccg cttcggacag ctcggcaccg gccccgcgta
    15601 ccagacggga ggacaccagc aacaggcaca cgacatcagg gcgcgagagg ccgttctcca
    15661 ggtcctccag cgtgtacgcc tcctcggtgc ccacggcgac cggaacagca cccgcaagcc
    15721 gtacggcctg cgtgatggag tggccgtaat cgaccgcgtg gcccgccggc aggacgacgg
    15781 cgcggggcat cccggtcgtg tccggcaggg ccgcgatgcg ctccgcggac tcccccgtca
    15841 tcgtggccgc gaccgcgagg gtgatcgcgg acgccgtgca gtgcaccacc gtccccgcct
    15901 ctgccccggc gaaccgggcg agcgcgcgat cggccacgtc ctggagttcc accatgacga
    15961 agaactccga cagggccgcg gcgaccgccg tggcaacacc ctccccactg cgtgagacgc
    16021 ccaacggggt gtacgggccc cgcgcgttga tgatccgggt gagtccgtag gtggagtgaa
    16081 gtcccatgga cgacatcctg cctggctgac gggatcaagt ccccgacggg ggtgcccggt
    16141 tgatccaccg cgggtccgcc cggcccgtga ctcgtcctgg aggcccgccg ccgggcccgg
    16201 gcggggacgc gggccggccg actggaaggg cggaccctgc cgatcggccg ccgcccgggc
    16261 gggccgcccc cgactgcctg gccgaaccac ccggctgccg ggctcaactc cccgtgctgc
    16321 gcaggttctc acgcaccttg gcgatggcga agccccagcc ctgctggacg gtgggcttgg
    16381 ccgggacggc gatctcgtca gggttggtga gcacgtcgag gaggacggga ccgggctcgg
    16441 caaaggtgcg ctcgatcgct tcggccagat cctcggcgcg ctccacgcga atgcccttga
    16501 tgccgagcgc ctcggcgacc gccgcgaagt ttgggttgtc caggacggtg ccgaactcgg
    16561 gcagaccggc ctgctcctgt tcgagcttca ccatgccaag gcgccggttg tcgaagacga
    16621 cgagcttgac gggcagtcgc tcggtacgga tcgtcatcag gtcgccgagc agcatggaca
    16681 gaccgccgtc gccgcagaac gcgatggtct ggcggtcgcg gtccaggaac tgcgcgccga
    16741 tggcctgcgg catcgcgttg gccatggacc ccaggttgta ggagccgatc agccgtcggc
    16801 tgccgcgcat ctcgacgaag cgggagagcc agacggtggc catgccggtg tcggaggtga
    16861 acacggcgtc gtcgtcggcc gcggcgtcca ccgcggcggc gagcgcctcg gggcgtacga
    16921 ggtgatcgcg gttgtcgaag gcggaacgga ccttgccgat caggcccttg tcatggccgg
    16981 gtgcggcgag cctgcgctgg ccgtcctgcc agtgcgtgaa cttctcgcgc gcggaatcga
    17041 ggtgctttcg gtcctcgcgg ggggcgacgc gctccaggag gccgcgcacg gtggggccga
    17101 catcggcggc gagcgccacg tcgacgggca cgcgtcgccc gatgtgctcg gccacgcggt
    17161 ccacctggac gaccttcttg ccctccgggt accactcccg atacgggaag tcggtgccga
    17221 gcaggaccag cgtgtccgcg tggtccatgg catgggcggc ggccgggttg ccgatcaggc
    17281 cggtctggcc gacctggaag gggttgtcgc cctcgaagcc ctccttggcc ttgagggtga
    17341 ggaccatggg tgcggcgagc cggtcggcga gggcgaggac atcgtcacgc gaggtccggg
    17401 aaccacggcc gacgagaagg gtgacgttcc cgccttcgtc gatgaggcgg gcggcctcgt
    17461 cgagggccgg gtcgtcggga cggttctcgg aacgggcgac ggagagccgc agcggccggt
    17521 cgttgggcag ctcctggtcg ccgatgtcgc cggggatggt caggacggcg acgccccggc
    17581 ggccgatcgc ggtgcgcacg gcgacctcaa ggagggcggg gagctgctcg ggcgaggtga
    17641 cagtggcgcg gaagacggcg acgtccttga agaggaggtc gttgtcgacc tcctggaagt
    17701 agtcggtgcc gacctcggag cgcggcacct gcccggcgat ggcgagcacg ggcgtgccgc
    17761 tcttggccgc gtcgtacagg ccgttgagca ggtgcaccga gccggggccg acggtgccca
    17821 tgcagacgcc cagggtgtcg gtgagctgcg actgggctcc ggccgcgaac gcggcggcct
    17881 cctcgtggcg gcagccgacc caggagaggg cgtcggaggt ccggatggcg tcggtgagcg
    17941 ggttgagcgc gtcacccacg actccgaaga cctgccgcac tccgagttct tcgagagcat
    18001 cgacgaagag gcgggcgacg gtgcgggaca tggaggggtg tcctttctgt ggggccggcc
    18061 cgcggggcgt ggcccgcggt tcttcagtga tcgggcgtcg ggtccgtaca tccggtgcgc
    18121 ccggcgcgga tggttcaaac aggatggggc gaaggggact gccgagcggt cagccggtga
    18181 agctgtccgg atcggccgcc ttccagtcgg caccccaccc ggcgggcggg tcgagggtca
    18241 gctcgccggg cttcagccac tcgtagagct ccgcgtagga gcgaaagtcg tcgccgtcgg
    18301 tggcgcggcg gcgcagcagg tgcgggccga ggtcgccggg gtcggagacc cccatcgcgg
    18361 ccatgatctt cagggcgctg gagacggtcg cctcctggaa gcgctcgacc cgctcggact
    18421 tgtccgcgac atcgagggct cgggcccggc gcgggtcctg ggtggtgacg ccggtggggc
    18481 agcggttggt gtggcagcgc tgcgcctgaa tgcagccgac ggcgaacatc atggcgcggg
    18541 ccgcgttggt ccagtcggcg cccatggcaa ggcgcttgac gatgtcggag ccggtggcca
    18601 ccttgccgct ggcgccgatc cggatgcggt cgcgcagtcc ggcgccgacc agcgcgttgt
    18661 ggacggtgat cagcccttcg gtgagcggca tgcccaggtg gtcggcgaac tccagcgggg
    18721 ccgcgccggt gccgccttcg gcgccgtcga cgacgatgaa gtcgggggtg atgttctccg
    18781 cgatcatcgc cttgcacacg gcgaggaact gcacgcggga gccggggcag agcttgaagc
    18841 cgaccggctt gccgtcggcg agctcgcgca tccgggccag gaaccgcacc atctcgcgcg
    18901 gggtggagaa gacgcggtgg tacggcggtg agacgaccgt cttcccctcg gggacaccgc
    18961 ggacctgggc gatctcgctg ttgaccttgt cgccgggcag tactcctccc atgccgggtt
    19021 tggcgccctg ggagagcttg agggagacgc acttgacggc cgggtgagcg gctttctcgc
    19081 ggaacttgtc cggatcgaag tcgccgtcct tcgtacggca gccgaaatag ccggtgccta
    19141 tctcccagat gatgtcgccg ccgggacgca ggtggtactc ggagaggccc ccctcaccgg
    19201 tgtcgtgggc gaaccctccc cgtgcggcgc ccgtgttgag agcgaggacg gcgttgccgg
    19261 agagggagcc gaagctcatc gcggagacgt tgagcagcgc catgtcgtac ggacgcgtgc
    19321 agtcggggcc gccgacccgc acccggggtg cctccttcgg catgtcgacc ggacgcatcg
    19381 acggcaccag gaattcgtag ccgcggctgt acatgtcgcg ctcgctgccg aagggctcct
    19441 cggcgtcgac gcccttggcc cgctcgtaga cgatgctgcg ggtgtcgcgg tcgtaggggc
    19501 ggccgtcgta attgcgttcc acgaagtact gctggagctc ggggcggatc gcctctagga
    19561 ggaaacgggc gtgccccaga acgggatagt tgcgcaggac cgaatggcgg cgctggagca
    19621 ggtcgtagca tccgagcagg gcgattgcgc cgagcagagc cccggcgaac caccaccacg
    19681 gcgagacgac gaacgccgag gtcaccgctg cggctgcaca cacaatgagt agggccacgg
    19741 ccccgaatcg caccatggat gaccggatat ccgggatcga ggcattcatg tacgcccagg
    19801 accttcgctc ccgcctcgga ctcggccgag gacgccaccg gttccgtatc cggctgcccc
    19861 cgggccatcg gggcacgctc cctggggacg gtgtggttgg ggcggtgttg ttccagaggc
    19921 cgacgaaccg ccatcggcgc ctggtccggg tcggaccggt tcgccgccgc ccgctcttcg
    19981 ccggccgcac tctcaataac cggttggaga gcaggtcgac cactgctatg ttttcggagg
    20041 ccgtgcgaga cgtagaggag gtggtacccg tgaacgcagt atcgacatgg gtgctcccct
    20101 ccggggtcat ggtcgggcga tagtcaggtc gtccgggagc gccgttccag tgcactcccg
    20161 aaaggcaaga ccatgcggtt cacttctgaa cagcacctcg aagacggcgt ccgtgagcgc
    20221 catttcaccc tcggtgggat ccccggcatc ctgtggaccc ccgcatccgc caccccgacc
    20281 acaccggcac cactgattct gctcggccac cctcccctcg ggctgcgcaa gatgcacccg
    20341 cggttggtga cccgggcccg gcactccgcg gcggacggct tcgccagtgc caccatcgag
    20401 ctccccggaa gcggtgaccg gcctcgtctg cccgccgtcg agcagtcccg agccgacctg
    20461 cgccgggcgc tggcggccgg cgagccggtc agcgacgagg tcgtcgacgc cgtcgtcctc
    20521 ccgttggtcg acagggcggt cccggagtgg cagaccgccc tggacgcggt cctgtcgctg
    20581 cccgagatcg gcggcccggt cggatactcg ggcggagtga tctccatcgg catccggctc
    20641 gcgctggtcg agccacgcat ctcggccgcc gttctgttcg ccgggagttt cgtgcctcgc
    20701 gccgtgttcg aggaggcccg gcagatcacc attccgctgc acgtcctgct gcagtgggac
    20761 gacgaaggca acgaccgcca ggcagccctg gacctgttcg acgccttcgg ctcccaggac
    20821 aagtccctgc acgccaatat gggcgggcac accggcgtcc cgcagttcgc aggggaagcc
    20881 gccgcccagt tcttcacccg gcacctgaag tgaggccatg ccgacggacc ggtagcacat
    20941 agcggctgat ggcggcaggc cggccaccca tcgagggcgg tgccctgccg ccgtcaccgc
    21001 tcattacgtc gcggggccgc cgtcaccgct caccacctcg cgggcctctg ctgattctcg
    21061 gcaggggccc gcgctgcggc ggcaagtggc cccatgccgc ggtgtgcggc tgggcccagt
    21121 cacccttgtt cccgtggccg ctcgcccctc gcccacacct ccggtcagcg cagagagcgg
    21181 atcgccgggc tcgtggccac caggcctgcg cacgccagga cggcgccgcc gcacaccagg
    21241 aacagcgtcg ccgtgccgaa ggggaccagg acaccggcaa gcaggtagga gaaggggtcg
    21301 aaggccaccg tggcgaggac gacgaggctg agcacacggc ccagcaatcg ctgcggaacc
    21361 cgctcctgca gggtggccac gacgaccact ccgaggaacg cggacccgag gccgatgagc
    21421 gaaacgaccg ccgtggcggc cacgacatcg gtgacggccg ccagtccggc catgcccgca
    21481 ccgatcgccg cgaccccgcc gaccacggtc cagccgcgcc gggcgggcgg gcgccacccg
    21541 gccacgagcg aaccggccag cgaaccggca ccgaaaccgg agagcacgat gcccaaggac
    21601 ccggcgccgc cgaggcgttg atcggcgagc accgctccac ccacgagcac gggacccacg
    21661 accgtgatgt tgatcagcgc gatggctgcc agcatccccc gcaccaccgg ctcgcgccac
    21721 gcgtatctca agcccgcacc cagggcacgc gcggtgctga cccgctcacc gtcgacctcg
    21781 tccggcccgg cagcgccccc ggcacgttcg ccacgccgca ccgcccggat gggcatgctg
    21841 agggcgacgg cggccagcgc ggccagcgcc acgatccctc cgagcgtcgc gtcgaagccg
    21901 acgacggcga tgactccggc ggccaccgcg gggccgacca gatcgccccc cgactccgcg
    21961 ccctgcacga gcgcgttgac ccgggcgagc ttctcggtcg gtacgacggc gggaagcagt
    22021 gcgagggctg cggggaagta cgcggcgtcg gcggcaccga gcagtccggc gagcagggcg
    22081 accgtcgcca ccgatggcga ggtgagggtg accagggcgc cgagggcgag caggaccgcg
    22141 acccggagcc aggccgcgcc ggccgcgata cgggcgggac cgacgcggtc gaccagcacg
    22201 cccgcgggaa gcaggagtgc cgctcgtggc agtgccactg ccaccaggac gaaacccgtg
    22261 gtcatccccg gttccgacag cttcagcacg aagagcgtga gccagatgag gaacagcgcg
    22321 tcgaccacgg ccgccaggcc ctggcccacg atcagtcggc gcaggtgcgt gtcgccgagc
    22381 ggttcgctcg gcagggatcg ggcggtcggc tccgtcgtca tcgcccgctc cccgcggcgc
    22441 catctggatc gccaccgtgc ggaaagcggt cgaccacagg agccttgatg ggtaactccc
    22501 ttgcagcacg gcccagttga cggatcggct cgatggccgc gtcgtcaccg ccgccgggtc
    22561 cgcacccggc tgaacccgga cggtcgggac cgcccctctc tccgatcgac aactggaaca
    22621 catccactcg cttccgatgg gacgcgctgc gtcggcagac tcaccctgcc tgt
//
