LOCUS       NZ_CP070373            20696 bp    DNA     linear   CON 18-MAY-2024
DEFINITION  Streptomyces sp. MBT27 chromosome, complete genome.
ACCESSION   NZ_CP070373
VERSION     NZ_CP070373.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MBT27
  ORGANISM  Streptomyces sp. MBT27
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8400223)
  AUTHORS   Machushynets,N.V., Wu,C., Elsayed,S.S., Hankemeier,T. and van
            Wezel,G.P.
  TITLE     Discovery of novel glycerolated quinazolinones from Streptomyces sp.
            MBT27
  JOURNAL   J Ind Microbiol Biotechnol 46 (3-4), 483-492 (2019)
   PUBMED   30729343
REFERENCE   2  (bases 1 to 8400223)
  AUTHORS   Machushynets,N., Elsayed,S., Carrion,V.J., Siegler,M.A., de la
            Cruz,M., Genilloud,O., Hankemeier,T. and van Wezel,G.P.
  TITLE     New from old: conjugation of actinomycin X2 and anthranilamide to
            form the novel actinomycin L in Streptomyces sp. MBT27
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8400223)
  AUTHORS   Du,C., Machushynets,N. and van Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2021) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
REFERENCE   4  (bases 1 to 8400223)
  AUTHORS   Machushynets,N.V., Wu,C., Elsayed,S., Hankemeier,T. and Van
            Wezel,G.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JAN-2020) Molecular Biotechnology, Institute of
            Biology Leiden, Sylviusweg 72, Leiden 2333BE, Netherlands
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 1.8.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 130.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011751035.2-RS_2024_05_18
            Annotation Date                   :: 05/18/2024 03:23:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,575
            CDSs (total)                      :: 7,482
            Genes (coding)                    :: 7,345
            CDSs (with protein)               :: 7,345
            Genes (RNA)                       :: 93
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 137
            CDSs (without protein)            :: 137
            Pseudo Genes (ambiguous residues) :: 0 of 137
            Pseudo Genes (frameshifted)       :: 39 of 137
            Pseudo Genes (incomplete)         :: 114 of 137
            Pseudo Genes (internal stop)      :: 17 of 137
            Pseudo Genes (multiple problems)  :: 27 of 137
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:14:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1699978
            Orig. end                         :: 1720674
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070373.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from MBT, Institute of Biology
            Leiden, Leiden University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20696
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="3"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20696
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20696
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10696](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10696)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    297..310
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.14"
                     /tool="antismash"
     misc_feature    complement(298..311)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    complement(466..479)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            1949..3178
                     /locus_tag="GWQ54_RS07735"
     CDS             1949..3178
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236057.1"
                     /locus_tag="GWQ54_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_161248693.1"
                     /transl_table=11
                     /translation="MRDVLKRAGAGTAAALAWAGLTAVLVTALTGCSGGALDIGDIGGK
                     PLTPQEAILVTPDDGAKGVKADQKVEVRVPGGRLERVKVMKTEDAQPEEVPGKISEDGL
                     TWTPTGGALQLAALYTVDTVALDGHGRRQARHTSFATLVPEHRFIGYFKPENRSTVGVG
                     MIVSFNFNQGIKDKAAVERAIRITSQPPVEVRGHWFGKDRLDFRPEKYWVPGTKVTVDM
                     RLRDVLAAPDVYGIQDKTIGFTVGRDQESLVDAEAHTMEVRRGGELVSTLPISAGSPKN
                     TTYNGKMIVTEMYDVTRMNSQTVGFGGEYDIPDVPHAIRLTNTGTFLHGNYWAPSSTFG
                     NSNTSHGCVGLRDVKGGSSDTPAGWFFDRTLIGDVVEVVNSHDREVAPDNGLSGWNLDW
                     AKWKAGSAIS"
     misc_feature    complement(3337..3352)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(3348..3358)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            3474..4709
                     /locus_tag="GWQ54_RS07740"
     CDS             3474..4709
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457224.1"
                     /locus_tag="GWQ54_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_167156758.1"
                     /transl_table=11
                     /translation="MNGQPISGAAAGRSGRRGSAVLALICGALLLLVTACGGGDGGSKS
                     KAGSAGATEDTKASEAVVDVVPADNAKDVATNGALKISADKGRLTAVAVADSKGNAVAG
                     KISADGLGWVPDQHLASATQYKVHAVAKDAKGRESAKDTTFTTLVPKNTFIGQYVPEDG
                     STVGVGMPVSINFSRGITNPDAVEKAITVTAEPSVPVEGHWFGNDRLDFRPENYWAPGT
                     KVTVKLNLDGVEGRPGVYGKQTRTVHFTIGRSQVSTVDASAHTMKVERDGKLLKTIPIS
                     AGSPQNTTYNGQMVISEKFEVTRMNGATVGFGGEYDIKDVPHAMRLSSSGTFIHGNYWG
                     DPSVFGSANTSHGCVGLRDARGAGDPSTPAAWFYNSSLIGDVVVVKNSKDKVIQADNGL
                     NGWNLSWSEWTK"
     gene            4791..5558
                     /locus_tag="GWQ54_RS07745"
     CDS             4791..5558
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (4-246). E-value: 1.6e-76. Score:
                     248.8. Matches aSDomain:
                     nrpspksdomains_GWQ54_RS07745_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432556.1"
                     /locus_tag="GWQ54_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_161248689.1"
                     /transl_table=11
                     /translation="MTVNLEVSEGVGTIRLNRPPMNALDVATQDRLRELAEEAARRDDV
                     RAVVLYGGEKLFAAGADIKEMQAMDHAAMVVRGRALQESFTAVARIPKPVVAAVTGYAL
                     GGGCELALCADFRIAGDNAKLGQPEILLGLIPGAGGTQRLARLVGPSKAKDLIFTGRQV
                     KADEALAMGLVDQVVPAAEVYERAHAWAARLAQGPAIALRAAKESIDTGLEADIDTGLA
                     VERNWFAGLFATEDRERGMRSFVEEGPGKAKFL"
     aSDomain        4803..5528
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GWQ54_RS07745_ECH.1"
                     /evalue="1.60E-76"
                     /label="GWQ54_RS07745_ECH.1"
                     /locus_tag="GWQ54_RS07745"
                     /protein_end="246"
                     /protein_start="4"
                     /score="248.8"
                     /tool="antismash"
                     /translation="LEVSEGVGTIRLNRPPMNALDVATQDRLRELAEEAARRDDVRAVV
                     LYGGEKLFAAGADIKEMQAMDHAAMVVRGRALQESFTAVARIPKPVVAAVTGYALGGGC
                     ELALCADFRIAGDNAKLGQPEILLGLIPGAGGTQRLARLVGPSKAKDLIFTGRQVKADE
                     ALAMGLVDQVVPAAEVYERAHAWAARLAQGPAIALRAAKESIDTGLEADIDTGLAVERN
                     WFAGLFATEDRERGMRSFVE"
     gene            5845..6348
                     /locus_tag="GWQ54_RS07750"
     CDS             5845..6348
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048437.1"
                     /locus_tag="GWQ54_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_161248687.1"
                     /transl_table=11
                     /translation="MAGLEGVEQPAQRVSATAARWMPSADDELALKALELFGNPTEEEV
                     RLPSRPESAATARRITQSVVLRQWALSPTLAEHAVLLVSELVGNAVRHTGARVFGLRML
                     RRRGWIRIEVRDPSRGLPCLMPVHELDVSGRGLFLVDKLSDRWGVDLLPRGKTTWFEMR
                     VADR"
     gene            6753..7568
                     /locus_tag="GWQ54_RS07755"
     CDS             6753..7568
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550126.1"
                     /locus_tag="GWQ54_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_189764235.1"
                     /transl_table=11
                     /translation="MNPSPRAVDRRSALRAGAGAAIVGAFTTGCSDDKGGARPAESPTP
                     PSASAAAAAPARPGKSRPAPAPRAFPGQPVQIESGPRARPQVALTFHGQGDPKIATTLL
                     SEAEKAGARVTVLAVGSWLDEQPAMARRILDGGHELGNHTQHHIDISTMDESEAYAEIT
                     GCADRLRRLTGSIGTWFRPSRAQYATPLVQKLARQAGYPHVLSYDVDSLDFTSPGASAV
                     TRNVTGQIRNGSVVSLHFGYADTVAALPVLLAELERRRLRAVTTTELLI"
     gene            7568..8749
                     /locus_tag="GWQ54_RS07760"
     CDS             7568..8749
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889607.1"
                     /locus_tag="GWQ54_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YncE family protein"
                     /protein_id="WP_167156756.1"
                     /transl_table=11
                     /translation="MPTATKTTTALLAAVLLAALAGCGSGPDHKDEALSTKAALPPAVV
                     KKPLPQGLPGMPPVLDPKDAYAADRPNALQPAVKNFLPRVYVPNTNSNTVSVIDPATYK
                     VIETIPVGHQPQHVVPSWDMKTLWVNNDLGDSLTAIDPATGKTGRTVQVSDPYNLYFTP
                     NGKYAIVMASMDRELVFRDPVTMNRVKTVPVTCAGVNHADFSMDGRYFIVSCEFSGELL
                     KVDTEKMQIVGQQKLPFDGAMPQDVKMSPDGKTFYVADMMAHGMWVLNGDKFDKPVLLP
                     TGKGCHGLYISRDSKEMYISNRGEGTISIFDFTKDKLTKKWELPDGGSPDMGGVSADGK
                     VLWLSGRYNAEVYAIDTATGKELARIPVGSGPHGLAVYPQPGRYSLGHTGIFR"
     gene            complement(8814..10004)
                     /locus_tag="GWQ54_RS07765"
     CDS             complement(8814..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889608.1"
                     /locus_tag="GWQ54_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_167156754.1"
                     /sec_met_domain="p450 (E-value: 1.2e-14, bitscore: 52.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPEPVLDFPLSRRGDVLPEECTWLREKQPVARVRTLTGDQAWLV
                     SSHALAKQVLEDERFSLKDTAAPGVPRQYALTIPPEVVNNMGNINSAGLRSAVMKSLSP
                     RADGLVDRLRERAGEFVDALLTEGPPADLRAGFADPFSAALHCQVIGVPFTDWRRLMSG
                     LDTAFMTSAHTFEGAGLNWYKDLGYMVERLNAPDVPPDSLLGRLGALREDRESAHLTDE
                     MLATVAVSMFGAGAVSTSAFLSLAVLALLQHPELIGHLREHPERMGRAVDELLRWNLSI
                     GDGLPRLALEDVRLGEVLVEKGELVLVLVEGANFDPAVFSDPERLDLDREHNPHLSFGA
                     GRHFCPATGLGRLHAETALSVLVDRMPGLRLAVPAEQLVWRTGFIKRLPERLPVLW"
     gene            complement(10001..10696)
                     /locus_tag="GWQ54_RS07770"
     CDS             complement(10001..10696)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889609.1"
                     /locus_tag="GWQ54_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_167156752.1"
                     /sec_met_domain="CDPS (E-value: 2.7e-84, bitscore: 281.0,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAITTEAFTVQPFTRSCHHIWDEGDHVLIGVSPGNSYFSAGRITE
                     LVRWASARFSRIDIVYADLHVADLFSALGYERDHAARRASKELKAVRRRILRGIEDADP
                     QGTPVDVHGLSEFAGNPVYELLHRRVRHFLSTDPHFRAGCEHMAAHFLATKVGEPAVSA
                     EQLSACLDYIVAELPFFLDTPGILGVPSSVSCYHAPIPLTELLYAKGGGLRASRNQAYA
                     VVRPEGTAA"
     gene            11058..11270
                     /locus_tag="GWQ54_RS07775"
     CDS             11058..11270
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961912.1"
                     /locus_tag="GWQ54_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_161251968.1"
                     /transl_table=11
                     /translation="MADIEEARKAFAKLDVDGDGRVTASEYKAVMAQLGDFHVTETVAQ
                     AIIRAKDANGDGKLSFEEFWASLNK"
     gene            11332..12054
                     /locus_tag="GWQ54_RS07780"
     CDS             11332..12054
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151202.1"
                     /locus_tag="GWQ54_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_275901403.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.8e-09, bitscore:
                     35.3, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSGRGFSERVNAPTPEGQLMKIGIIGAGNIGGNLTRRLTALGH
                     QVSIANSRGPHTLSALAEETGATPVTVEQAADGAQVVVVTIPLKNVPALPKGLFDKAAD
                     GLAVIDTGNYYPKERDGRIDAIEDGLPESRWTEQHIGHPVIKVFNGTYAQDLLDRPRPK
                     GAPDRVAVPVAGDDAAAKQLVRELVDELGFDTVDAGGIDDSWRQQPATPVYGLRGNTAE
                     VTEALAAAPKERPAAHSA"
     gene            complement(12074..13444)
                     /locus_tag="GWQ54_RS07785"
     CDS             complement(12074..13444)
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009063 - amino acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889625.1"
                     /locus_tag="GWQ54_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="L-serine ammonia-lyase"
                     /protein_id="WP_161251963.1"
                     /transl_table=11
                     /translation="MAISVFDLFSIGIGPSSSHTVGPMRAARMFAARLKNEGLIAHTAR
                     IRSELYGSLGATGHGHGTPKAVLLGLEGASPRTVDVENADARVEKIKDSGRLNVLGMHE
                     IGFAYDDDLVLHRRKALPYHANGMTVFAYDVDGALLLEKTYYSVGGGFVVDEDAVAGEN
                     PIVPDDTVLRHPFRTGDELLRLAQDTGLSISALMLENEKAWRTEDEIRSGLLDIWRVMQ
                     ACVSRGMSREGILPGGLKVRRRAANTARLLRAEGNPEAHAMEWATLYAMAVNEENAAGG
                     RVVTAPTNGAAGIIPAVLHYYMNFVPGADEDGIVRFLLAAGAIGMLFKENASISGAEVG
                     CQGEVGSACSMAAGALAEVLGGTPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNG
                     MAAVKAVTAAKMAMRGDGSHKVSLDKVIKTMKETGADMSVKYKETARGGLAVNIIEC"
     gene            complement(13602..14861)
                     /gene="glyA"
                     /locus_tag="GWQ54_RS07790"
     CDS             complement(13602..14861)
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (77-368). E-value:
                     5.6e-14. Score: 43.9. Matches aSDomain:
                     nrpspksdomains_GWQ54_RS07790_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="glyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007457161.1"
                     /locus_tag="GWQ54_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydroxymethyltransferase"
                     /protein_id="WP_161251961.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.9e-12, bitscore:
                     43.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLNQPLHELDPDVAAAVDAELHRQQSTLEMIASENFAPVAVME
                     AQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRIKALFGAEAANVQPHSGAQANAA
                     AMFALLKPGDTIMGLNLAHGGHLTHGMKINFSGKLYNVVPYHVDETGEVDMAEVERLAK
                     ESKPKLIVAGWSAYPRQLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHV
                     VTTTTHKTLGGPRGGVILSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASPEF
                     KERQQRTLDGARILAERLVQDDVRAVGVDVLTGGTDVHLVLVDLRNSELDGQQAEDRLH
                     EVGITVNRNAIPNDPRPPMVTSGLRIGTPALATRGFGDDDFREVADIIAEALKPDFDQD
                     ALAARVSALAAKHPLYPGLK"
     aSDomain        complement(13758..14630)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GWQ54_RS07790_Aminotran_1_2.1"
                     /evalue="5.60E-14"
                     /label="GWQ54_RS07790_Aminotran_1_2.1"
                     /locus_tag="GWQ54_RS07790"
                     /protein_end="368"
                     /protein_start="77"
                     /score="43.9"
                     /tool="antismash"
                     /translation="AIDRIKALFGAEAANVQPHSGAQANAAAMFALLKPGDTIMGLNLA
                     HGGHLTHGMKINFSGKLYNVVPYHVDETGEVDMAEVERLAKESKPKLIVAGWSAYPRQL
                     DFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHVVTTTTHKTLGGPRGGVIL
                     STQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASPEFKERQQRTLDGARILAERL
                     VQDDVRAVGVDVLTGGTDVHLVLVDLRNSELDGQQAEDRLHEVGITVNRNAIPNDPRPP
                     MVTSGLRIGT"
     gene            complement(14900..15274)
                     /gene="gcvH"
                     /locus_tag="GWQ54_RS07795"
     CDS             complement(14900..15274)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /gene="gcvH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946794.1"
                     /locus_tag="GWQ54_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="WP_161251959.1"
                     /transl_table=11
                     /translation="MSNPQQLRYSKEHEWLSSAEDGVSTVGITEHAANALGDVVYVQLP
                     EVGDTVTAGETCGELESTKSVSDLYSPVTGEVVAANQDVVDDPSLVNSAPFEGGWLFKV
                     KVTDEPGDLLSADEYTDFAS"
     gene            complement(15375..16499)
                     /gene="gcvT"
                     /locus_tag="GWQ54_RS07800"
     CDS             complement(15375..16499)
                     /EC_number="2.1.2.10"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004047 - aminomethyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /gene="gcvT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018509776.1"
                     /locus_tag="GWQ54_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycine cleavage system aminomethyltransferase
                     GcvT"
                     /protein_id="WP_167156748.1"
                     /transl_table=11
                     /translation="MSNAPRLTSLDALHRSLGATMTDFAGWDMPLRYGSERDEHNAVRT
                     RAGLFDLSHMGEITVTGPEAMKALNYALVGNIATIGLGRARYTMICQEDGGIVDDLIVY
                     RLGETEAPEYLVVANAGNAQIVLDAITERAAGFDAEVRDDRDAYALIAVQGPESPGILK
                     SVTDADLDGLKYYAGLPGTVAGVPALIARTGYTGEDGFELFVAPEHAERLWRALTEAGQ
                     DAGLVPCGLSCRDTLRLEAGMPLYGHELTTALTPFDAGLGRVVKFEKDGDFVGRKALEA
                     AAEKAEANPPRKLVGLIAEGRRVPRAGFSVVAGGEVVGEVTSGAPSPTLGKPIAIAYVD
                     AAHAAPGTEGVGIDIRGTHEAYEVVALPFYKRQK"
     regulatory      complement(16653..16750)
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            16880..17548
                     /locus_tag="GWQ54_RS07805"
     CDS             16880..17548
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036331.1"
                     /locus_tag="GWQ54_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_167156746.1"
                     /transl_table=11
                     /translation="MTVGHGTGRTREAPEAEGPGRAAQDRPPRPVMGEAVRDLRGRPGR
                     TPPELLFDAGDVVVVSGLPGSGKTTLMRRTVTDRRIDSQDTRLAWQRRLPGIPYALYRP
                     LTRTAHFARTWWALRSGDSLVVHDCGTQAWVRHWLGRGARRRGRALRLVVLDVAPGTAL
                     EGQAARGRWVSRYAFARHRGAARRLIAQVEAGRLPTGCASAVLLDRESASVLHRIGFTK
                     "
     gene            17655..18428
                     /locus_tag="GWQ54_RS07810"
     CDS             17655..18428
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048456.1"
                     /locus_tag="GWQ54_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enhanced serine sensitivity protein SseB"
                     /protein_id="WP_167156744.1"
                     /transl_table=11
                     /translation="MNFPEQAFAHPHGGGGWPGNELEEVLSAAVGQPDAGPRLIEVLGR
                     NPVWVPLPNGGSRDSRDLDLPTMELDGSPYVPVYSSEQQFLRCVGSHMSFAVAPAVEFA
                     RGLPPQLGIVVNPEGAVGMPLPPPAVAELCRTGLTALDGPASGARVRLFEPDWQEEPVD
                     FLAVAAEEFEAIGVVLSARRALASIEGEPPTLFIGVEFATWDGAGRGAPMEALGRALGR
                     VPVGWPVNLVLLDVTQDPVATWMRERVRPFYARAQ"
     gene            18596..19393
                     /locus_tag="GWQ54_RS07815"
     CDS             18596..19393
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946790.1"
                     /locus_tag="GWQ54_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enhanced serine sensitivity protein SseB
                     C-terminal domain-containing protein"
                     /protein_id="WP_167156742.1"
                     /transl_table=11
                     /translation="MSASGTAAAGQVEHMLRQVTPGRYDVYEALLHALADPASGRIWML
                     LWNGRPGSPDAQYGNMEVDGVSYAPCVTSVQELSASGWNRDHEVTGALDIARSLYPDRY
                     GIWLNPHAPGGGVGIPWTDLRRIATGLDRMPAGPLRLSEPAVEIPQFYALLAQHAHRTP
                     AVRSLRRAWVQPALGTPYLAIGLDLYDTGPQSVDAVRAMMQQSIPAVPDGLAVSTVAMS
                     DAYDPVGMWLKAATRPFYDREAHAAPAPGGPGYGYPPAAPRTY"
     misc_feature    19521..19535
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.2"
                     /tool="antismash"
     misc_feature    complement(20605..20625)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.9"
                     /tool="antismash"
ORIGIN
        1 gcgcccggct gctccaggag cgaccagtcg agccagctca cctcgccgtc ctggcagtac
       61 gcgttgttgt tgccgccctg ggtgcggccc atctcgtcgc ccgcgaccag catcggcacg
      121 cccgtcgaca cgagcagggt ggtgagcagg ttccgcagct ggcgccggcg gagcgcgttg
      181 acctccgggt cgtcggtctc gccctccacc ccgcagttcc aggcccggtt gtcgtcggtg
      241 ccgtcccggt tgccctcgcc gttggcctcg ttgtgcttgc gctcgtacga caccaggtcc
      301 cgcagcgtga agccgtcgtg cgcggtgatg aagttgatgg acgcgtaggg gcgccggccg
      361 ccccaggcgt acaggtcgct ggagcccgag aggcggtagc cgaggtcgcg catgtccggc
      421 agcgcgcccc gccagaagtc ccgtaccgcg tcccggtagc ggtcgttcca ctcggtccac
      481 agcggcggga aggcacccac ctggtagccg ccgttgccca cgtcccacgg ttcggcgatc
      541 agcttcacgc ggcgcagcac cgggtcctgg gcgatcaccg cgaggaaggg cgacagcatg
      601 tcgacgtcgt gcatcgagcg ggccagcgcc gccgcgaggt cgaaccggaa gccgtccacc
      661 cccatctcgg tgacccagta gcgcagcgag tcggtgatca ggcgcagcac atggggctgg
      721 accacgtgca gggtgttgcc gcagccggtg tagtcggcgt agcgccgggc gtccgcctgg
      781 aggcggtagt agccgcggtt gtcgatgccg cgcagggaca gcgtcggccc catctcgctc
      841 gcctcggcgg tgtggttgta gaccacgtcg aggatcacct cgatgcccgc ctcgtgcagt
      901 gcccgcacca tccgcttgaa ctcgccgacc tgctgtcccg cggtgccgct cgccgagtag
      961 ccggcgtgcg gcgcgaagta gccgatcgag ttgtagcccc agtagttctt caggccccgc
     1021 cgcagcagat ggtcctcgtg cgcgaactgg tgcaccggaa gcagctcgac cgcggtgacc
     1081 ccgagccgca ccaggtggtc gatcgcggcc gggtgcgcga gcccggcgta ggtgccgcgc
     1141 agcggttcgg ggatgtccgg gtgcagccgg gtgaagccgc gtacgtgcag ttcgtagatc
     1201 actgagtcgg accagggcgt cttggggcgg cggtcgtcgg cccagtcgtc gtcgtcctgc
     1261 accaccacgc ccttggggac gtgcggcgcc gagtcgcggt cgtcgcgcac ggtgtcggcg
     1321 acctgctgct gcggccagtc ccgtacgtgc ccgtacacct cgggcggcag cacgaagtcg
     1381 ccgtccacgg cgcgcgcgta cgggtcgagc agcagcttcg ccgggttcca acgggccccc
     1441 gtccacgggt cccagcgccc gtgcacccgg aatccgtacc gctgcccggg gcgcaccccg
     1501 gggacgaagc cgtgccagat ctcatgggtc agctcggtga ggacgagccg ggtctcggtg
     1561 cccgccgcgt cgaacaggca cagctccacc gattcggcgc ctcccgccca cagcgcgaag
     1621 ttggtgcccg cgaccccgtc cgggccgacc cggaagcggg cgcccagcgg cgtgggggcg
     1681 cccggccaga ccggggggcg cagggccccc ggttcacccc ggtggccgtt caccgtgcgg
     1741 gacccctccg taccgggggc gccgcccacg gcactttgca ctgccttctg ttcggctgcg
     1801 ctcgacacct gacggcctcc cgcggctcgg cgcgggggcg gcagcggcgt cccggccgcg
     1861 gcttccctgc gcgtctctgc acctgttctt cccgcaacag ccctcgtact cacgtttccc
     1921 ccggcggggg gcggtcgttg ggccggtcgt gagagacgta ctgaagcggg caggggcggg
     1981 cacggccgcc gccctggcat gggcaggact gacggcggtc ctggtgaccg cgctgaccgg
     2041 gtgctcgggc ggcgccctgg acatcggcga catcggcggc aagccgttga cgccgcagga
     2101 ggccatcctg gtgaccccgg acgacggggc caagggagtc aaggcggacc agaaggtgga
     2161 ggtgcgggtg ccgggcgggc gcctggaacg ggtcaaggtc atgaagacgg aggacgcgca
     2221 gcccgaggag gtaccgggga agatctccga ggacgggctg acctggacgc cgaccggggg
     2281 cgcgctgcag ctggcggccc tctacacggt ggacaccgtg gcgctcgacg gccacggccg
     2341 ccgccaggcc cggcacacca gcttcgccac cctcgtgccc gagcaccgct tcatcgggta
     2401 cttcaagccg gagaaccgct cgacggtggg cgtcggcatg atcgtgtcgt tcaacttcaa
     2461 ccaggggatc aaggacaagg cggccgtcga gcgcgccatc aggatcacct cgcagccccc
     2521 cgtggaggtg cgcggccact ggttcggcaa ggaccggctc gacttccggc ccgagaagta
     2581 ctgggtgccc ggcaccaagg tcaccgtcga catgcggctg cgcgatgtgc tcgcggcccc
     2641 cgacgtctac ggcatccagg acaagacgat cggcttcacc gtggggcgcg accaggagtc
     2701 cctggtggac gccgaggcgc acaccatgga ggtgcggcgc ggcggcgaac tggtgtcgac
     2761 gctgccgatc tccgcggggt cgccgaagaa caccacgtac aacgggaaga tgatcgtcac
     2821 cgagatgtac gacgtgacgc ggatgaacag ccagaccgtc gggttcggcg gggagtacga
     2881 cattccggac gtgccgcacg ccatccggct caccaacacc ggcaccttcc tgcacggaaa
     2941 ctactgggct ccctccagca ccttcggcaa ctccaacacc agccacggct gtgtcggact
     3001 gcgggacgtg aagggcggca gctcggacac cccggcgggc tggttcttcg accgcaccct
     3061 catcggcgac gtggtcgagg tcgtcaactc ccatgaccgc gaggtcgctc cggacaacgg
     3121 gctcagtggc tggaacctgg actgggcgaa gtggaaggcg ggctccgcca tctcctgaga
     3181 gccgcccgcg gatctgccga ggacccgctg aggcccgctg aggccccctg aggaccttct
     3241 gggccccgca ccctcgaacg cacggcccca tgaccgttcc cggttaacca accgggaacg
     3301 gttcctgtgt ttcacctgag agttccagga aaacttggga ctgaacggtg acatgggagg
     3361 gggagatcgg ggccggttcg gtgtgattat ctagcgccgt gcgcgcgagg acgtgcgcgg
     3421 gggtgagtga gtgcgggcgg tggcggggcc acgccgtgcg aggggagaaa gtcttgaacg
     3481 ggcagcctat ttcgggggcc gcggccggac ggagtggtcg tcggggcagc gcagtgctgg
     3541 ccctcatatg cggggcgctg ctgctcctcg tcaccgcgtg cggcggaggc gacggcggat
     3601 ccaagtcgaa ggccggcagc gcgggcgcca ccgaggacac caaggcgtcc gaggccgtgg
     3661 tcgacgtcgt cccggcggac aacgccaagg acgtcgccac caacggcgcg ctgaagatat
     3721 ccgccgacaa gggcaggctg accgccgtcg cggtcgccga cagcaagggc aacgcggtcg
     3781 ccgggaagat atccgcggac ggcctcggct gggtcccgga ccagcacctc gcctccgcca
     3841 cgcagtacaa ggtccacgcg gtcgccaagg acgccaaggg ccgcgagtcc gccaaggaca
     3901 ccacgttcac cacgctcgtc ccgaagaaca ccttcatcgg ccagtacgtg cccgaggacg
     3961 gctccaccgt cggcgtcggg atgccggtct ccatcaactt cagccggggc atcaccaacc
     4021 cggacgcggt cgagaaggcg atcaccgtga cggccgagcc gtccgtcccg gtcgagggcc
     4081 actggttcgg caacgaccgc ctcgacttcc gccccgagaa ctactgggcg cccggcacca
     4141 aggtcaccgt caagctgaac ctggacggtg tcgagggccg gcccggtgtc tacggcaagc
     4201 agacccgcac cgtccacttc accatcggcc gctcccaggt ctccaccgtc gacgcgagcg
     4261 ctcacaccat gaaggtggag cgcgacggca agctcctgaa gaccatcccg atcagcgcgg
     4321 gctccccgca gaacaccaca tacaacgggc agatggtcat cagtgagaag ttcgaggtga
     4381 cgcgcatgaa cggcgccacc gtcggcttcg gcggcgagta cgacatcaag gacgtgccgc
     4441 acgcgatgcg cctgtccagc tcgggcacct tcatccacgg caactactgg ggcgacccgt
     4501 cggtgttcgg ctcggccaac accagccacg gctgcgtcgg tctgcgcgac gcacgcggcg
     4561 cgggcgaccc gtcgacgccg gccgcctggt tctacaacag ctccctgatc ggcgacgtgg
     4621 tcgtcgtgaa gaactccaag gacaaggtca tccaggccga caacggtctc aacggctgga
     4681 acctctcctg gtcggagtgg accaagtagg cccgaaccga ccccgacgga cccggtgctg
     4741 tgagcgacag caccgggtcc gttgccatta gtggccgtta acctgccttc atgactgtga
     4801 acctggaagt ctccgagggc gtcggcacca tccgcctgaa ccgccccccg atgaacgcgc
     4861 tcgacgtcgc gacgcaggac cggctgcgcg agctggccga ggaggcggcc cggcgcgacg
     4921 acgtgcgggc ggtggtcctg tacggcggcg agaagctgtt cgcggcgggc gcggacatca
     4981 aggaaatgca ggcgatggac cacgcggcga tggtcgtgcg cggccgggcg ctgcaggagt
     5041 ccttcaccgc cgtcgcccgg atccccaagc ctgtcgtggc ggccgtcacc ggctacgcgc
     5101 tcggcggcgg ctgcgagttg gcgctgtgcg ccgacttccg catcgccggc gacaacgcca
     5161 agctcggcca gcccgagatc ctgctcggcc tgatcccggg cgcgggtggc acccagcgcc
     5221 tggcccggct ggtcggcccg tccaaggcga aggacctgat cttcaccggc cgccaggtga
     5281 aggcggacga ggcgctcgcc atgggcctcg tcgaccaggt ggtgccggcc gccgaggtgt
     5341 acgagcgggc ccacgcctgg gccgcgcgcc ttgcgcaggg cccggcgatc gcgctgcgcg
     5401 ccgccaagga gtccatcgac acgggtctgg aggcggacat cgacacgggc ctcgccgtcg
     5461 aacgcaactg gttcgcgggc ctgttcgcca ccgaggaccg tgagcggggc atgcgcagct
     5521 tcgtcgagga gggcccgggc aaggccaagt tcctctgagc gcaggcaagt tgagggcgct
     5581 gggtcaacga cggctgtaca tgtgatggtg atgtgtacac cctgtggggg gattagcgca
     5641 gccttaaggg caccttaagg aaaacctctc cggaacgctt ggtgatcaag cgaacgcggc
     5701 aggtcatcgc aggtcggagg gggtgtggcc gcctctggac tgcccctgac atatgccaag
     5761 cagcgcctcc ggagcgtcgg gttccggagg cgctattcct tcggaaccgc cccggaggcc
     5821 gccccgggcc gccatgatgg aggcatggcg gggctggagg gtgtggaaca accggcgcag
     5881 cgcgtgagtg cgaccgcggc acgctggatg ccgtccgccg acgacgaact ggcgctgaag
     5941 gcgctggagt tgttcggtaa tccgacggag gaagaagtgc ggctgccgtc gcggccggag
     6001 tccgcggcga cggcccgccg gatcacccag tccgtggtgc tgcgccagtg ggcgctctcg
     6061 ccgaccctcg ccgaacatgc ggtgctgctc gtctccgagc tcgtcggcaa cgcggtccgg
     6121 cacaccgggg cccgggtctt cgggctgcgg atgctgcgcc gccggggctg gatccggatc
     6181 gaggtgcgcg acccctcgcg cggcctgccc tgtctgatgc cggtgcacga gctcgacgtc
     6241 agcgggcggg gcctcttcct cgtcgacaag ctctccgacc gctggggcgt ggatctgctg
     6301 ccgcgcggca agaccacctg gttcgagatg cgggtcgccg accgctgagg cgccggtcgc
     6361 gacggccggg aatcacagaa gccccctggc tgccggttgc ggcgcctgcg ggggcttctg
     6421 tggagcgccg cggatcgaag ggggtgtgat ccacggcgac tgaagacgac ctggcccggg
     6481 tcaatggggg tcgtggctcc gactatgaca gatgggcgcc ccatcctcaa aagtccttag
     6541 tcagacataa cgggatgaac tattacagtt tagctgtgaa tcgtaggtga gctacagcac
     6601 tcaccttcca aagcatgaat aagtatcggg acccctgagt gaatcagtgc cctgggtgcc
     6661 ccccgagcgg ccccgggcaa cgcgacccgc aaaggtcctg aagtgggtca atcgttacca
     6721 accgaccctc ggcgcactta aatgtccatg tgctgaatcc atcaccccgt gcggtagacc
     6781 gccgcagcgc cctgcgggcc ggggcgggcg cggccatcgt gggggcattc acgacgggct
     6841 gctcggacga caagggcggc gcgcggccgg ccgaatcccc gacgccgccg tccgcctccg
     6901 cggcggccgc cgcccccgcc cgccccggca agtcccgccc cgcaccggcc ccccgcgcct
     6961 ttcccgggca gccggtccag atcgagagcg gaccccgggc ccgcccgcag gtcgccctca
     7021 ccttccacgg ccagggcgat ccgaagatcg ccaccaccct gctcagcgag gccgagaagg
     7081 ccggtgcccg cgtcaccgtc ctcgccgtcg gcagctggct cgacgagcag cccgcgatgg
     7141 cccgccgcat cctggacggc ggccacgaac tgggcaacca cacccagcac cacatcgaca
     7201 tctccaccat ggacgagtcg gaggcgtacg ccgagatcac cggctgcgcg gaccgcctgc
     7261 gccggctcac cggctccatc gggacgtggt tccgcccctc ccgtgcccag tacgcgacgc
     7321 cgctcgttca gaaactggcc cggcaggcgg gttacccgca cgtcctgtcg tacgacgtcg
     7381 actcgctcga cttcacctcg cccggcgcct cggccgtgac ccgcaacgtc accgggcaga
     7441 tccgcaacgg atcggtggtg agcctgcact tcggctatgc ggacacggtc gccgcgctgc
     7501 ccgtcctact cgccgaactg gaacgccgcc gactgcgcgc ggtcacgacc acggagctgc
     7561 tgatctgatg ccgaccgcaa cgaagacgac caccgcgctg ctcgccgccg tcctgctcgc
     7621 ggccctcgcc ggctgcggct cgggccccga ccacaaggac gaggcgctca gcaccaaggc
     7681 ggcgctcccg cccgccgtcg tcaagaagcc cctgccgcag ggcctgcccg ggatgccgcc
     7741 cgtcctcgac cccaaggacg cctacgcggc ggaccggccg aacgcgctgc agcccgcggt
     7801 gaagaacttc ctgccgcgcg tgtacgtgcc caacaccaac tccaacacgg tgtccgtgat
     7861 cgacccggcc acgtacaagg tcatcgagac gatcccggtc ggccaccagc cgcagcacgt
     7921 cgtgccgtcg tgggacatga agacgctgtg ggtcaacaac gacctgggcg actcgctcac
     7981 cgccatcgac ccggcgaccg gcaagaccgg ccgtaccgtg caggtctccg acccgtacaa
     8041 cctgtacttc acgcccaacg gcaagtacgc catcgtcatg gcctcgatgg accgcgagct
     8101 cgtcttccgc gaccccgtca ccatgaaccg ggtcaagacc gtcccggtga cctgcgcggg
     8161 cgtcaaccac gcggacttct ccatggacgg ccggtacttc atcgtctcct gcgagttctc
     8221 cggcgagctg ctcaaggtcg acaccgagaa gatgcagatc gtcggccagc agaagctgcc
     8281 gttcgacggg gcgatgccgc aggacgtgaa gatgtccccg gacggcaaga cgttctacgt
     8341 ggccgacatg atggcccacg gcatgtgggt cctgaacggc gacaagttcg acaagccggt
     8401 cctgctgccc accggcaagg gctgccacgg gctctacatc agccgcgact ccaaggagat
     8461 gtacatctcc aaccgtggcg agggcaccat ctccatcttc gacttcacca aggacaagct
     8521 caccaagaag tgggaactgc cggacggcgg cagccccgac atgggcggcg tctccgccga
     8581 cggcaaggtg ctctggctgt ccggccgcta caacgccgag gtgtacgcca tcgacaccgc
     8641 caccggcaag gagctggccc gcatccccgt cggctcgggc ccgcacggcc tcgccgtcta
     8701 cccccagccg ggccggtact cgctcggcca caccggcatc ttccgctgag ccggccccgg
     8761 tccgcaccgc caccacgtgc cccgaggccc gccggccccg gggcacccgc cggtcaccac
     8821 agcaccggca gccgctccgg caggcgcttg atgaagccgg tgcgccacac cagctgctcg
     8881 gccggcaccg cgaggcgcag ccccggcatc cggtccacca ggaccgagag cgcggtctcc
     8941 gcgtgcagcc ggccgaggcc cgtggcaggg cagaagtgcc ggccggcccc gaacgacaga
     9001 tgcgggttgt gctcccggtc gaggtccagg cgctcggggt cgctgaagac cgccgggtcg
     9061 aagttggcgc cctcgaccag gacgagcacc aactcgccct tctcgacgag gacttcaccc
     9121 aggcgcacgt cctccagggc gagccgcggc agcccgtcgc cgatggacag gttccagcgc
     9181 agcagttcgt ccacggcccg gcccatgcgc tcggggtgtt cgcgcagatg gccgatcagc
     9241 tccgggtgct ggagcagggc caggaccgcc aggctcagga acgcggaggt cgagaccgcg
     9301 cccgcgccga acatggacac cgcgaccgtg gccagcatct cgtccgtcag atgcgcggac
     9361 tcccggtcct cgcgcagcgc tccgagccgg ccgagcaggc tgtccggcgg cacatcgggc
     9421 gcgttcagcc gctccaccat gtacccgagg tccttgtacc agttgagccc ggcaccttcg
     9481 aaggtgtgcg cgctcgtcat gaacgcggtg tccaggcccg acatcagccg ccgccagtcc
     9541 gtgaacggaa ccccgatcac ctggcagtgc agcgccgccg agaaggggtc ggcgaacccc
     9601 gcccggaggt cggccggcgg gccctcggtg agcagcgcgt cgacgaactc cccggcccgc
     9661 tcgcgcagcc ggtcgacgag accgtcggcg cgcgggctca gggacttcat cacggcggag
     9721 cgcaggcccg cgctgttgat gttgcccatg ttgttgacga cctcgggcgg gatcgtcagc
     9781 gcgtactggc gcgggacgcc cggcgcggcg gtgtccttga ggctgaaccg ctcgtcctcc
     9841 aggacctgtt tggccagcgc gtgactgctc accagccagg cctggtcgcc ggtgagcgta
     9901 cggacccggg ccacgggctg cttctcgcgc agccaggtgc actcctcggg cagcacgtcc
     9961 ccgcggcgcg agagcgggaa gtcgagtacg ggctcggggg tcatgcggct gttccttccg
    10021 ggcgcaccac tgcgtaggcc tggttgcggg aggcgcggag cccgccgccc ttggcgtaga
    10081 ggagttcggt cagggggatc ggcgcgtggt agcacgacac cgaggagggg acgccgagga
    10141 tgcccggggt gtccaggaag aaggggagct cggcgacgat gtagtcgagg caggcggaga
    10201 gctgctccgc gctcacggcg ggttcgccga ccttcgtggc gaggaagtgc gccgccatgt
    10261 gctcacagcc cgcgcggaag tgcgggtcgg tggacaggaa gtgccgcacc cggcggtgca
    10321 gcagctcgta caccgggttc ccggcgaact ccgagagccc gtgcacatcg accggagtgc
    10381 cctgcgggtc cgcgtcctcg atgccgcgca gaatcctgcg gcgtaccgcc ttcagctcct
    10441 tggaggcgcg gcgggccgcg tggtcccgct cgtagccgag cgcgctgaac agatcggcca
    10501 catggaggtc ggcgtacacg atgtcgatgc gggagaaccg tgccgaagcc caacggacga
    10561 gttcggtgat gcggccggcg ctgaaatagc tgttacccgg actcacaccg atgaggacgt
    10621 gatcgccctc gtcccatatg tggtggcaac ttcgtgtgaa gggctgcacg gtgaatgctt
    10681 cagttgtgat ggccacagct gtaacgcccc agcgccgcta gtccctgggt gccctgtgct
    10741 cccggtgtgg cggcgacagc atgaagttat ccaccagtgg cggagcgtga ggaagcggcg
    10801 gcgggaagtt ggcgtgaact cccctttgtc gggcggaaaa ctgtcctccg tgtatggcga
    10861 acagtcaggg tcgcgggccc ttgggcgatt cggccgaacg tcggagtccg caccgccggg
    10921 attccagcgg cgggaaccgg ccatccgcag tggcggcgct caggagccat ccgccgcacg
    10981 gtgcgcgcac atcggcggct aatctgaccg gcgtcagaaa agcaccaagc agtagcacca
    11041 acaaaggggt ggacccagtg gcggacatcg aagaggcgcg caaggcgttc gcgaagctcg
    11101 acgtcgacgg tgacggacgc gtcaccgcga gcgagtacaa ggcggtcatg gcgcagctgg
    11161 gcgacttcca cgtcaccgag accgtggccc aggccatcat cagggccaag gacgccaacg
    11221 gcgacggcaa gctctccttc gaggagttct gggcgtccct gaacaagtga ccccgaccgg
    11281 tgccggtggc gcggaaccgc ctgggcggag cgccaccggt gccgggccgg aataacccgc
    11341 agtggccgtg ggttctcgga gcgtgtcaac gcaccaactc cggaaggcca gctcatgaag
    11401 atcggcatca tcggcgcggg caacatcggc ggcaacctga cccgccgcct caccgcactc
    11461 ggccaccagg tgtccatcgc caactcccgt ggcccgcaca ccctttccgc cctcgcggag
    11521 gagacgggcg cgaccccggt caccgtcgag caggcggccg acggcgccca ggtcgtcgtg
    11581 gtcaccatcc cgctgaagaa cgtgcccgcc ctgcccaagg gcctgttcga caaggccgcc
    11641 gacggcctcg ccgtcatcga caccgggaac tactacccga aggagcgcga cggccggatc
    11701 gacgcgatcg aggacggcct ccccgagagc cgctggaccg agcagcacat cggccatccg
    11761 gtgatcaagg tcttcaacgg cacgtacgcg caggacctcc tggaccggcc gcgccccaag
    11821 ggcgcccccg accgggtcgc cgtgcccgtc gccggggacg acgcggccgc caagcaactg
    11881 gtccgcgagc tcgtcgacga gctgggcttc gacaccgtgg acgcgggcgg catcgacgac
    11941 tcctggcgcc agcagcccgc cacccccgtc tacggcctgc gcggcaacac ggcggaggtc
    12001 accgaggccc tggcggcggc ccccaaggag cgcccggcgg cgcactccgc ctgagcggag
    12061 ccgggagacc ggctcagcac tcgatgatgt tgacggcgag gccgccgcgg gccgtctcct
    12121 tgtacttgac gctcatgtcg gcccccgtct ccttcatcgt cttgatgacc ttgtccaggg
    12181 acaccttgtg gctgccgtca ccacgcatcg ccatcttggc ggcggtgacg gccttcaccg
    12241 cggccatgcc gttgcgctcg atgcacggga tctggaccag gccgccgacc gggtcgcagg
    12301 tcaggcccag gttgtgctcc atgccgatct cggccgcgtt ctcgacctgc tcgggggtgc
    12361 cgccgagcac ctcggcgagc gcgcccgccg ccatcgagca ggcggagccg acctcgccct
    12421 ggcagccgac ctcggcgccg gagatcgagg cgttctcctt gaacagcatg ccgatcgcgc
    12481 cggcggcgag caggaagcgg acgatgccgt cctcatcggc tccgggcacg aagttcatgt
    12541 agtagtgcag gaccgccggg atgatgccgg ccgcgccgtt ggtgggcgcg gtcacgaccc
    12601 ggccgcccgc cgcgttctcc tcgttgaccg ccatcgcgta cagcgtcgcc cactccatgg
    12661 cgtgcgcctc ggggttgccc tcggcgcgca gcaggcgggc ggtgttggcg gcgcggcggc
    12721 ggaccttgag gccgccgggc aggatgccct cgcgggacat gccgcgcgag acacaggcct
    12781 gcatgacccg ccagatgtcg aggagcccgg agcggatctc gtcctcggtg cgccacgcct
    12841 tctcgttctc cagcatcagc gcggagatgg agaggcccgt gtcctgcgcg aggcggagca
    12901 gctcgtcgcc ggtgcggaag gggtgccgca ggacggtgtc gtccggcacg atcgggttct
    12961 cgccggccac ggcgtcctcg tcgacgacga agccgccgcc gaccgagtag tacgtcttct
    13021 ccaggagcag cgcgccgtcg acgtcgtacg cgaagaccgt catgccgttg gcgtggtagg
    13081 gcagcgcctt gcggcggtgc aggaccaggt cgtcgtcgta ggcgaagccg atctcgtgca
    13141 tgccgaggac gttgagccgc ccggagtcct tgatcttctc cacccgcgcg tcggcgttct
    13201 ccacgtcgac cgtgcgcggg gacgcgccct ccaggccgag cagcaccgcc ttcggggtgc
    13261 cgtggccgtg gccggtcgcg ccgagcgagc cgtacagctc ggaccgtatc cgcgcggtgt
    13321 gggcgatgag gccctcgttc ttgagccgcg cggcgaacat ccgggccgcg cgcatcgggc
    13381 cgacggtgtg ggagctggac gggccgatgc cgatcgagaa caggtcgaag accgagatgg
    13441 ccacgggaga ctccttgtgg gggttggtag acgccgttgt ctgccggggt atcgcagagc
    13501 aaagctggca cagcatggga tggggcaccg cgctcactac ccagtgtgcg cggtgccccg
    13561 gggcttcgta cggaatgaac cgagaacgaa agcgtacgaa actacttcag gccggggtac
    13621 agggggtgct tcgcggccag agcggacacc cgggcggcca gggcgtcctg gtcgaagtcc
    13681 ggcttcaggg cctcggcgat gatgtcggcg acctcacgga agtcgtcgtc tccgaagccg
    13741 cgggtggcga gcgccggggt gccgatccgc aggcccgagg tcaccatcgg cggccgcggg
    13801 tcgttcggga tggcgttccg gttgaccgtg atgccgacct cgtggaggcg gtcctcggcc
    13861 tgctggccgt ccagctccga gttgcgcagg tccaccagga ccaggtgcac atcggtgccg
    13921 ccggtcagga cgtcgacgcc gacggcccgc acgtcgtcct ggaccaggcg ctcggccaga
    13981 atccgggcgc cgtccagggt gcgctgctgg cgctccttga actcgggcga ggccgcgacc
    14041 ttgaacgaca ccgccttcgc cgcgatgacg tgctccaggg gaccgccctg ctggcccggg
    14101 aagaccgccg agttgatctt cttggcgagc tcctgcgtcg acaggatgac accgccgcgc
    14161 ggaccgccga gggtcttgtg cgtggtggtg gtcacgacgt gggcgtgcgg caccgggttg
    14221 gggtgcagac ccgcggcgac caggcccgcg aagtgggcca tgtcgaccat caggtacgca
    14281 ccgacctcgt ccgcgatgcg gcggaaggcg gcgaagtcca gctggcgcgg gtacgcggac
    14341 cagccggcca cgatcagctt cggcttggac tccttggcca ggcgctcgac ctcggccatg
    14401 tcgacctcgc cggtctcgtc gacgtggtac gggaccacgt tgtagagctt gccggagaag
    14461 ttgatcttca tgccgtgggt caggtgaccg ccgtgggcca ggttcagacc catgatcgtg
    14521 tcgcccggct tcagcagcgc gaacatcgcg gccgcgttgg cctgggcgcc cgagtgcggc
    14581 tgcacgttgg cggcctcggc gccgaacagc gccttgatgc ggtcgatcgc gatctgctcg
    14641 accacgtcga cgtgctcgca gccgccgtag tagcggcggc ccgggtagcc ctcggcgtac
    14701 ttgttggtga ggaccgagcc ctgggcctcc atgaccgcga ccggagcgaa gttctccgag
    14761 gcgatcatct cgagggtgga ctgctggcgg tggagctcgg cgtcgacggc ggcggcgacg
    14821 tccgggtcca gctcgtggag gggctggttc agaagcgaca tcagacgatc ccttgaatcc
    14881 cttgtcccag tggcctgggt cagctggcga agtcggtgta ctcgtcggcg gagagcaggt
    14941 cgcccggctc gtccgtgacc ttcaccttga acagccaacc gccctcgaac ggggccgagt
    15001 tgacgagcga ggggtcgtcc acgacgtcct ggttggcggc gacgacctcg ccggtgaccg
    15061 gggagtacag gtcgctgacc gacttggtgg actccagctc gccgcaggtc tcgcccgcgg
    15121 tcaccgtgtc acccacctcc gggagctgga cgtacaccac gtcaccgagc gcgttggccg
    15181 cgtgctccgt gatgccgacc gtcgagacgc cgtcctcggc gctcgacagc cactcgtgct
    15241 ccttgctgta gcgaagctgc tgcgggttgc tcatgacctg aattctcctg tacgcggggg
    15301 agtgctggtg acggggtctg gacgagtgtc tcggacgccg agacgggaaa ggggctgccg
    15361 gacggaggcg ctcgtcactt ctggcgcttg tagaagggca gcgcgacgac ctcgtacgcc
    15421 tcgtgcgtgc cgcggatgtc gatgccgaca ccttcggtgc cgggcgcggc gtgcgcggcg
    15481 tccacgtatg cgatcgcgat cggcttgccg agtgtcgggg agggggcgcc cgaggtgacc
    15541 tcgccgacga cctcgccgcc ggccaccacc gagaacccgg cgcgcggcac ccggcgcccc
    15601 tcggcgatca ggccgaccag cttgcgcggc gggttggcct cggccttctc ggcggcggcc
    15661 tccagcgcct tgcggccgac gaagtcgccg tccttctcga acttcacgac ccggccgagc
    15721 cccgcgtcga acggcgtgag cgcggtggtc agctcgtgcc cgtacagcgg catgcccgct
    15781 tcgaggcgca gcgtgtcgcg gcaggacagg ccgcatggca cgaggcccgc gtcctggccg
    15841 gcctcggtca acgcccgcca cagccgctcg gcgtgctccg gcgccacgaa cagctcgaag
    15901 ccgtcctcac cggtgtagcc ggtgcgggcg atcagcgcgg gcacaccggc gaccgtgccg
    15961 ggcagaccgg cgtagtactt caggccgtcg aggtcggcgt cggtgacgga cttcaggatg
    16021 ccgggggact cggggccctg caccgcgatg agcgcgtagg cgtcccggtc gtcgcggacc
    16081 tcggcgtcga agccggccgc gcgctcggtg atcgcgtcga gcacgatctg cgcgttgccc
    16141 gcgttggcga cgaccaggta ttcgggggcc tcggtctcgc ccaggcggta gacgatcagg
    16201 tcgtcgacga tcccgccgtc ctcctggcag atcatcgtgt accgggcgcg gccgaggccg
    16261 atggtggcga tgttgccgac cagcgcgtag ttcagcgcct tcatggcctc ggggccggtg
    16321 acggtgatct cgcccatgtg ggacaggtcg aagagcccgg cgcgggtgcg cacggcgttg
    16381 tgctcgtcgc gctcgctccc gtaccgcagc ggcatgtccc agcccgcgaa gtcggtcatc
    16441 gtggcgccca gcgaacgatg cagggcatcg agggaggtca gacggggggc gttgctcatg
    16501 gatgttgctc caaggtcccg gggcatgacg gtcgaggaca tcctccccat ctgtcatcgg
    16561 aacctgagag gttcaccgtc gcgcgctgcg cggcacggct tgcaccttgg gtgggaccgt
    16621 ccggcagggg acggtccgct tttcagatct gcctcgtccg cgcggtacgg ggcctgagag
    16681 attcaaggga ggaacttgct ccttcggcgc cccagctcac agctgctgag gactctcccg
    16741 cgcggattcg aacggccggt atgcagttgg cgcgcacatc attgcacgca tcccggaagc
    16801 ggcaaatcgc ttgagcccta ttaccgtctc tttacacttc cagggcaggg gtccgggaat
    16861 ccgaacaggg gggagtgcca tgacggttgg acacggaacg ggccggacgc gggaggcgcc
    16921 cgaggcggaa gggccggggc gggcggcgca ggaccggccg ccgcgcccgg tgatgggcga
    16981 ggcggtgcgg gacctgcgcg ggcggcccgg gcgcaccccg cccgagctgc tcttcgacgc
    17041 gggggacgtc gtggtggtgt cgggtctgcc cggaagcggc aagacgacac tgatgcgccg
    17101 caccgtcacc gaccgccgca tcgactccca ggacacccgc ctcgcctggc agcgccggct
    17161 ccccggcatc ccgtacgccc tctaccgccc gctcacccgc accgcgcact tcgccaggac
    17221 ctggtgggcg ctgcgctccg gcgacagcct cgtcgtgcac gactgcggga cgcaggcctg
    17281 ggtgcggcac tggctgggcc ggggcgcccg gcgccggggg cgcgcgctgc gcctggtcgt
    17341 gctcgacgtg gcgcccggca ccgccctgga gggccaggcc gcccggggcc gctgggtgtc
    17401 gaggtacgcg ttcgcccggc accgcggtgc ggcccgccgc ctcatagccc aggtggaggc
    17461 cggacggctg ccgaccggct gcgcgagcgc ggtgctgctc gaccgcgagt cggcgtcggt
    17521 actgcaccgc atcggcttca cgaagtagcg ccgcatggcg tgcgccgggc ccattcccgg
    17581 caccctttcc gcggcgcgcg tcggcggcgc tagggtcgag gggcacgaca gcagtcgggg
    17641 gagaaggacg gcacatgaac tttccggagc aggcgttcgc gcatccgcac ggcggcgggg
    17701 gatggcccgg caacgagctc gaagaggtcc tgtccgcggc cgtcgggcag cccgacgcgg
    17761 gcccccgcct catagaggtg ctcggccgca accccgtatg ggtgccgctg cccaacggcg
    17821 gcagccggga cagcagggac ctcgacctgc ccaccatgga gctcgacggc tccccctacg
    17881 tgccggtgta cagctccgag cagcagttcc tgcgctgtgt cggctcccac atgtcgttcg
    17941 ccgtcgcccc cgccgtcgag ttcgcgcgcg ggctgccgcc gcagctcggc atcgtcgtca
    18001 accccgaggg cgcggtgggc atgccgctgc ctccgcccgc cgtcgccgaa ctgtgccgca
    18061 ccggactcac cgcgctcgac gggcccgcgt cgggcgcgcg ggtgcggctc ttcgagccgg
    18121 actggcagga ggagccggtc gacttcctgg ccgtcgcggc cgaggagttc gaggcgatcg
    18181 gcgtggtgct cagcgcccgc cgcgcgctcg cctccatcga gggcgagccg cccacgctct
    18241 tcatcggcgt ggagttcgcc acctgggacg gggcggggcg cggcgccccc atggaggcgc
    18301 tcggccgggc gctcggccgg gtcccggtcg gctggccggt caatctggtc ctgctcgacg
    18361 tgacccagga tccggtcgcc acctggatgc gcgagcgggt acggcccttc tacgcacggg
    18421 cccagtagca accaccgggt gcgtcgcggc aggtcccgcc gggtcatggc ggtgtctgta
    18481 cggcggctta acctggtttc atgacccttg cacccccgca gccgcacgcg tgtgcccggg
    18541 gctgcggggc ggcgcaggcg tcggcacggt ggatcgaaga ggggcgggac ccagggtgag
    18601 cgcgtcaggc accgcggcgg ccgggcaggt cgagcacatg ctgcgccagg tgacccccgg
    18661 gcgctacgac gtgtacgagg cgctgctcca cgcgctcgcg gaccccgcat ccggccggat
    18721 ctggatgctg ctgtggaacg gccggccggg ctccccggat gcgcagtacg ggaacatgga
    18781 ggtcgacggc gtctcctacg cgccctgtgt cacctccgtg caggagctgt ccgccagcgg
    18841 ctggaaccgg gatcacgaag tgaccggcgc cctcgacatc gcccgctcgc tctaccccga
    18901 ccgctacggg atctggctca atccgcacgc ccccggcggc ggcgtcggca ttccctggac
    18961 ggatctgcgc cggatcgcca ccggcctcga ccggatgccc gcggggccgc tgcggctgtc
    19021 cgaaccggcc gtggagatcc cgcagttcta cgccctgctc gcgcagcacg cgcaccgcac
    19081 cccggccgtg cgctcgctgc gccgcgcctg ggtgcagccc gcgctcggca cgccgtacct
    19141 ggcgatcggg ctcgacctct acgacaccgg tccgcagtcg gtggacgcgg tgcgggcgat
    19201 gatgcagcag tccatccccg cggtgccgga cggcctcgcc gtctccaccg tcgcgatgtc
    19261 ggacgcgtac gacccggtcg gcatgtggct gaaggccgcc acgcggccct tctacgaccg
    19321 tgaggcgcac gccgccccgg cccccggcgg gcccggctac ggctacccgc cggccgcccc
    19381 acgcacgtac tgactccccc ggcacgtact gccccccgca cgtactgacc cgcgtgccgg
    19441 ggccgccccg cgtacggggg catgcccccg tccggcgccc caaccgggac agaccgtgcc
    19501 aactcccctc acgcgtaagg ggaatgtccg ttctgatggg gcgaacgccg caatggtcca
    19561 gcgcgtcgct tgcgccccaa cttccgcatg tccgcccctg gttcacctgc gtccgcataa
    19621 cggaaaccct ctttccgcat cacgtttacg catacattcg ccgccaggtc tggcgggtga
    19681 tcgcgacgcc attgaagact cccggcatgc agggccgttc gggcccttgt gcgagcagct
    19741 cgacccgctg cccggtgtcg ccccccgctc gcactgctga tgggaacgcg ccgctacagc
    19801 ggcaagtgcg ggccggtcac cgccggttga gaggggtcct tgccacgatg acggcaccat
    19861 tgcacgacac acccgccgac gcggacccga ccgcggacat cagtgtcacg ccgagcggcg
    19921 agaccagagc ggtcgaggga cgttcgctgg gccgcatcgc ctggaaccgg ctgaagaagg
    19981 acaagctcgc cctcaccggt ggcatcgttg tcgtgttcct ggtcctcgtc gcgatcttcg
    20041 ctccgttgat cgtcgacgcg ttcgggcacc cgccggacga cttccacgag gaccagatcg
    20101 acccgctgct ctcgaccccg gtgggcagct ggggcggcat caactcgcac ttcctgctgg
    20161 gtgttgagcc ggtcaacggc cgcgacgtgt tcagccggat cgtctacggc gcgcgcatct
    20221 cgctgctcgt gggcttcctc gcggccgtct tcgcggtcct ggtcggcacc gtcctcggcg
    20281 tgatcgccgg atacttcggc ggctggctcg acgccatcat cagccgcgtg atggacatgc
    20341 tgctctcctt cccgcagctg ctcttcatca tcgcgctgat ctccgtggtc cccaaccagc
    20401 tcttcggcct caacggcacc ggggtccggc tgctcgtgat gatcctggtg atcggcttct
    20461 tcgggtggcc gtacgtcgga cgcatcgtgc gcggccagac gctgtcgctg cgcgagcgcg
    20521 agtacgtcga ggcggcgcgc agtctcggcg cgggccgcgg ctacatcctg ttccgggagc
    20581 tgctgcccaa cctcatcgcg ccgatcaccg tctacatgac gctgatgatc cccacgaaca
    20641 tcctcaccga agcggcactc agcttcctgg gagcgggcgt caagccgccc acggcc
//
