LOCUS       NZ_CP036534            21029 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. VN1 chromosome, complete genome.
ACCESSION   NZ_CP036534
VERSION     NZ_CP036534.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. VN1
  ORGANISM  Streptomyces sp. VN1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8341703)
  AUTHORS   Nguyen,H.T., Pokhrel,A.R., Nguyen,C.T., Pham,V.T.T., Dhakal,D.,
            Lim,H.N., Jung,H.J., Kim,T.S., Yamaguchi,T. and Sohng,J.K.
  TITLE     Streptomyces sp. VN1, a producer of diverse metabolites including
            non-natural furan-type anticancer compound
  JOURNAL   Sci Rep 10 (1), 1756 (2020)
   PUBMED   32019976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8341703)
  AUTHORS   Pokhrel,A.R., Nguyen,H.T., Dhakal,D., Nguyen,C.T., Pham,V.T.T. and
            Sohng,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2019) Department of BT-Convergent Pharmaceutical
            Engineering, Institute of Biomolecule Reconstruction, Sunmoon-Ro221,
            Asan, Chungnam 333-708, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: HGAP3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011650445.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 03:53:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,284
            CDSs (total)                      :: 7,197
            Genes (coding)                    :: 7,083
            CDSs (with protein)               :: 7,083
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 44 of 114
            Pseudo Genes (incomplete)         :: 82 of 114
            Pseudo Genes (internal stop)      :: 3 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:32:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7656961
            Orig. end                         :: 7677990
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036534.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jae Kyung Sohng.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="31"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21029
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11029](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11029)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            249..485
                     /locus_tag="EZV63_RS33600"
                     /old_locus_tag="EZV63_34070"
     CDS             249..485
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979480.1"
                     /locus_tag="EZV63_RS33600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34070"
                     /product="hypothetical protein"
                     /protein_id="WP_031031956.1"
                     /transl_table=11
                     /translation="MTEIDSPHIGSPRILVLGVQPGTPPFRIVEIDGQVAGAARDVTDV
                     LEAAAAFGITVHDLDDPDVVRWVGGDKFTWTRR"
     gene            complement(516..1763)
                     /locus_tag="EZV63_RS33605"
                     /old_locus_tag="EZV63_34075"
     CDS             complement(516..1763)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325253.1"
                     /locus_tag="EZV63_RS33605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34075"
                     /product="glycoside hydrolase family 16 protein"
                     /protein_id="WP_037766831.1"
                     /transl_table=11
                     /translation="MVRPRLLRRCLLAAALSAGLAASLVTGPAQAEPEGPATAGASAAA
                     VVFSDTFDGPAGAAVDSSKWQIETGDNVDNHERQYYTSGNKNAALDGQGHLVVTARKEN
                     PANYQCWYGTCQYTSARLNTSGKFTAQYGHVEARMKVPRGQGMWPAFWMLGTPVNWPDS
                     GEIDIMENVGFEPSTVHGTLHGPGYSGAGGIGAGYTLPGGQAFADAFHTFAVDWAPDSV
                     TWSVDGNVYQRRTPADLGGRQWVFNRPYFLILNLAVGGYWPGDPDGSTVFPQTLVVDHV
                     SVTTGDSPAGGAIRGLAGKCVDVAAADTANGTPVQLYDCNGTTAQQWTVGSDGTIRALG
                     KCLDVNAGGTADGTVVQLWDCNGSAAQQWVVTAARDIVNPQADKCLDVTGNNSANGTRL
                     QIWTCAGTANQKWTVG"
     misc_feature    complement(1833..1846)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.1"
                     /tool="antismash"
     misc_feature    1834..1847
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.12"
                     /tool="antismash"
     misc_feature    complement(1835..1848)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.04"
                     /tool="antismash"
     misc_feature    complement(1836..1849)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.32"
                     /tool="antismash"
     misc_feature    1836..1850
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.82"
                     /tool="antismash"
     misc_feature    1871..1886
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.73"
                     /tool="antismash"
     gene            complement(1896..2435)
                     /locus_tag="EZV63_RS33610"
                     /old_locus_tag="EZV63_34080"
     CDS             complement(1896..2435)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389368.1"
                     /locus_tag="EZV63_RS33610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34080"
                     /product="VanZ family protein"
                     /protein_id="WP_037766828.1"
                     /transl_table=11
                     /translation="MARAVSGLRLWPRPRAAEARKADPPERHALALPLRLLATACAFVF
                     MVAFAVVLARLTLHPSPASEALTHTNMRPGSSLRAYLDQPALRDAVKQIGGNILLGVPF
                     GVLVPVVAPRTRGVLRVLLLTAVVMLLVEFAQGALVTGRAFDVDDVILNTSGALIGYLL
                     LGRRMSRSVHARKARD"
     gene            complement(2673..3356)
                     /locus_tag="EZV63_RS33615"
                     /old_locus_tag="EZV63_34085"
     CDS             complement(2673..3356)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430779.1"
                     /locus_tag="EZV63_RS33615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34085"
                     /product="DUF4230 domain-containing protein"
                     /protein_id="WP_031031951.1"
                     /transl_table=11
                     /translation="MTTPVKKPTSDDRKPAPRMPGWAKALTAVVLVLAVLFAGLRLSVL
                     PGLKDLFGSETQDRSGPALLKSIQDMSRYDAASGNFQVVVDLEKDTKFLPDAIRGTRTL
                     YVGAGTVDAYVDLGKLGEDDVQVDGDRTSATLRLPHAALGEPALDPDRSYAVSKQRGLL
                     DRLGDLFSDNPNGEQAVQKLASRHIGEAAKDSELKTRAESNTTAMLQGLLRSLGFDEVR
                     VAYKG"
     gene            complement(3626..4012)
                     /locus_tag="EZV63_RS33620"
                     /old_locus_tag="EZV63_34090"
     CDS             complement(3626..4012)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978079.1"
                     /locus_tag="EZV63_RS33620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34090"
                     /product="anti-sigma factor antagonist"
                     /protein_id="WP_031031948.1"
                     /transl_table=11
                     /translation="MRQESPSPTRHLRVRHERGHAVLEFRGEIDIASATEIAPRLDRET
                     RRPGARVVLDLGGIEFFDCSGVRLLARARNQVLAGGGEVHLVCSHPLTLRMLRITGLTR
                     LLPPRPTLREVLGPALPTARRTGC"
     misc_feature    4076..4090
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.5"
                     /tool="antismash"
     misc_feature    complement(4078..4094)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.67"
                     /tool="antismash"
     gene            complement(4167..5108)
                     /locus_tag="EZV63_RS33625"
                     /old_locus_tag="EZV63_34095"
     CDS             complement(4167..5108)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (21-310). E-value: 1.2e-56.
                     Score: 184.1. Matches aSDomain:
                     nrpspksdomains_EZV63_RS33625_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978080.1"
                     /locus_tag="EZV63_RS33625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34095"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_031031946.1"
                     /sec_met_domain="ADH_N (E-value: 1.2e-09, bitscore: 36.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 7e-19, bitscore:
                     66.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTMRAVSQDVLGGPEVLKEVRVERPVPRPNEVLVRVRAAGVNPT
                     DWKHRADGGFLGEPPFVLGWDVSGTVESVGIGVAAFRPGDEVFGMLSYPFGHGSHAEYV
                     TAPARTFTHLPAGTDHVRAGALPLVSLTAWQALVERADLQPGQRVLIHAAAGGVGHVAV
                     QIAKARGAHVIGTASAGKHAFLRSLGADEAVDYRETDFTEAVRDVDVVLDTIGGDTSLR
                     SLRVLRPGGVVVSILPVGSGEFFEEAGRLGVRAVRMLVDADRADMREIARLVEAGKLEP
                     TIAKTFPLAEAAGAHALGETGRTTGKIVLVVD"
     aSDomain        complement(4179..5045)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS33625_PKS_ER.1"
                     /evalue="1.20E-56"
                     /label="EZV63_RS33625_PKS_ER.1"
                     /locus_tag="EZV63_RS33625"
                     /protein_end="310"
                     /protein_start="21"
                     /score="184.1"
                     /tool="antismash"
                     /translation="RVERPVPRPNEVLVRVRAAGVNPTDWKHRADGGFLGEPPFVLGWD
                     VSGTVESVGIGVAAFRPGDEVFGMLSYPFGHGSHAEYVTAPARTFTHLPAGTDHVRAGA
                     LPLVSLTAWQALVERADLQPGQRVLIHAAAGGVGHVAVQIAKARGAHVIGTASAGKHAF
                     LRSLGADEAVDYRETDFTEAVRDVDVVLDTIGGDTSLRSLRVLRPGGVVVSILPVGSGE
                     FFEEAGRLGVRAVRMLVDADRADMREIARLVEAGKLEPTIAKTFPLAEAAGAHALGETG
                     RTTGKIVL"
     CDS_motif       complement(4611..4673)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS33625_0001"
                     /evalue="1.70E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="EZV63_RS33625"
                     /protein_end="166"
                     /protein_start="145"
                     /score="26.8"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHVAVQIA"
     misc_feature    5344..5358
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.06"
                     /tool="antismash"
     misc_feature    5350..5359
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     gene            5509..7266
                     /locus_tag="EZV63_RS33630"
                     /old_locus_tag="EZV63_34100"
     CDS             5509..7266
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327712.1"
                     /locus_tag="EZV63_RS33630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34100"
                     /product="ATP-binding protein"
                     /protein_id="WP_070389892.1"
                     /transl_table=11
                     /translation="MELATPPPAARVPVAWHSWWLMPLGLGGGTVAATFMSSERITVAV
                     AGAAATVAGTVCVRLLLRTRAQLGRAENAHRSARSENSQQWQQHVAGLERKFSAERSDL
                     DAQLTEQAQTYEERLAEHTRAYEDRIAEQATSYEARFAERTEAWQEQLGHQLAAVSRLA
                     DEQLPDAMRRLRSGDAIDDILPTVEQCSKVGADLQAELRKVLRTALIGVEAEFDRSTSA
                     EQAVISVGNRIHVLTSKLRGRLHEMQGEHGRLPTVARGLMELDQAIGPADCLAASIGVL
                     GGSDRPGRQWQEPQRLLSVMRGGIGRIKDFHRVQLRHLPELGVDGGLVDHLTLIFAHLL
                     DNAARYSPPTEPVVVSGKEVPNGVGIEIQDSGKGLSDEKKREAEHALAGTSPGAGLGGI
                     SEDANIGLRVVGALARRYGIRVTFADSPWLGTSVVVVVPHKYFSPLPSAAAPATVPDTA
                     QAVTAPAADLVPPAVVEAAAAPAPAVESTRAADPAPAADPAVETTPGGLPRRRSRRAEP
                     AAPSGAAAPTAQPPGSEAADRAQASAVPPDASFTGLAAFATAGRDPGAGTSESTTGGAS
                     TEHRTEESD"
     gene            7272..7682
                     /locus_tag="EZV63_RS33635"
                     /old_locus_tag="EZV63_34105"
     CDS             7272..7682
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057749.1"
                     /locus_tag="EZV63_RS33635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34105"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_031031941.1"
                     /transl_table=11
                     /translation="MTHQGTDVSWALRDLVESIQEIRFALVASSDGKAITSYGAEDPDD
                     VDRFAAVVAGLQALAQPVAEQFPQHAGQLRLAMIEVDGGHLFVVRAGMETYLGVLAREG
                     LDQGLLGHQMRDLARRMGELLGTTPRQEEHSG"
     gene            7679..8050
                     /locus_tag="EZV63_RS33640"
                     /old_locus_tag="EZV63_34110"
     CDS             7679..8050
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995719.1"
                     /locus_tag="EZV63_RS33640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34110"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_031031940.1"
                     /transl_table=11
                     /translation="MSAPRRPTDPSGLERYYVLTGGRSGPGGSASTLDVATLVVARAAP
                     LPGMQHEHEEILRRCRDPLSVAELGAHLHLPFNILAVLLSDLLQAGSVEARDPIPALDA
                     GRGPDLALLEEVLSGLQRL"
     misc_feature    7814..7816
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8031..8636
                     /locus_tag="EZV63_RS33645"
                     /old_locus_tag="EZV63_34115"
     CDS             8031..8636
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156547.1"
                     /locus_tag="EZV63_RS33645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34115"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_031031937.1"
                     /transl_table=11
                     /translation="MDFKGFDRPGSSTAGDTRSVKVMIAGGFGTGKTTMVRAVSDIKPL
                     TTEETLTQASADVDPLIGVADKTQTTVSLDFGKIGLNETLMLYLFGTPGQERFWFLWNG
                     LFKGALGAVVLVDTRRLASSFRAIEEMERQKVPFVIALNVFPDSRDYPVDEIRDALDIA
                     PHTPVVAFDARDPTAGRDVLVTLIRHLKDRSAAALEPR"
     gene            8633..9880
                     /locus_tag="EZV63_RS33650"
                     /old_locus_tag="EZV63_34120"
     CDS             8633..9880
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327716.1"
                     /locus_tag="EZV63_RS33650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34120"
                     /product="cytochrome P450"
                     /protein_id="WP_070389893.1"
                     /sec_met_domain="p450 (E-value: 1.2e-06, bitscore: 26.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDDQTPSAPTGGGCPVAHGEGAVRLYGPDAATDPHEIYARLRGE
                     HGAVAPVLLEDDVPAWLVLGYRENRRVLDNPLQFSRDSRIWRDFQDGRVAETAPLMQMV
                     GWRPDCVSQDGEPHRRLRGAVTDNLYAVAGRGIRRHITHFANKQIDAFADAGRADLVAD
                     FAEYLPMLVLTRVFGLAEREGRTLAESSNQVIKGGADALTHNERIMGILGELAERKRRE
                     PGSDFASGLIEHNSGLDEDEIVNHLRLVLITAHTTTSNLLARVLQLVLTDSARLSGLVS
                     GQLNMSAVVEEVMWNSPPLAVLPGRFATADLELGGCPVKEGDLLVLGLTAGNHDPEIRP
                     DTGVSVEGNASHLAFSAGPHECPGQNIGQAIIETAVDVLLHRLPGLRLAVPASELTSTA
                     STWESRLDSLPVEFAR"
     gene            complement(10001..11029)
                     /locus_tag="EZV63_RS33655"
                     /old_locus_tag="EZV63_34125"
     CDS             complement(10001..11029)
                     /EC_number="4.2.3.169"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040594.1"
                     /locus_tag="EZV63_RS33655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34125"
                     /product="7-epi-alpha-eudesmol synthase"
                     /protein_id="WP_031031934.1"
                     /sec_met_domain="T1TS (E-value: 5.3e-72, bitscore: 242.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQDVRFDLPFDTPVSPHLAHARERHLRWVRERGLVRSAAGFEEYR
                     SWDLSEAAARTYPHASADDMVVLMNWFSLAFLFDDQFDAARPDRAERIAEVARELIATP
                     LRPAGTPPRVECPITLAWAEVWGHLSDGMSLTWKSRFAASWGRFLVAHCEEVDLAAHGR
                     AATLGIEEYAVFRRRTVGIHHSIDAGERSRGFEVPAAAMAHPLMERMRDLAADTIGFMN
                     DIHSFERERRRGDGHNLVAVLQRERGCSWQEAAEEAYRMTTDCLDEYVALEARVPQMCD
                     ELGLDGDGRTRVRLGVEAIQHWINGNYEWALTTGRYAAAKDGPVATAEQAGRGSVDDLL
                     GV"
     misc_feature    complement(11215..11233)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.57"
                     /tool="antismash"
     gene            11290..11685
                     /locus_tag="EZV63_RS33660"
                     /old_locus_tag="EZV63_34130"
     CDS             11290..11685
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978082.1"
                     /locus_tag="EZV63_RS33660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34130"
                     /product="VOC family protein"
                     /protein_id="WP_031031931.1"
                     /transl_table=11
                     /translation="MALVNAGVVVLDCAEPERLAEFYKGLLGAEETDVTANRIEIEGPS
                     GFRLAFRRDVNATPPSWPRPENSLQVHLDLVVADLDEAERAIVGLGGRPVEAKDAAGPH
                     EERGFSDPAGHSFTLRLAVAPTAPKQG"
     gene            complement(11731..12033)
                     /locus_tag="EZV63_RS33665"
                     /old_locus_tag="EZV63_34135"
     CDS             complement(11731..12033)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979470.1"
                     /locus_tag="EZV63_RS33665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34135"
                     /product="DUF4235 domain-containing protein"
                     /protein_id="WP_166625589.1"
                     /transl_table=11
                     /translation="MAKTKKKKLPLAYKPVGFALGWLGGTLAGLAFQKTWKLIRDEDDA
                     PDALDPDRGWGEILLAAAIQGAIFAAVRSAVDRTGAKAIARSTGTWPIPGRGGRD"
     gene            complement(12131..13156)
                     /locus_tag="EZV63_RS33670"
                     /old_locus_tag="EZV63_34140"
     CDS             complement(12131..13156)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978084.1"
                     /locus_tag="EZV63_RS33670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34140"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_031031927.1"
                     /sec_met_domain="GST_C (E-value: 6.8e-07, bitscore: 28.2,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGDDATPGNSGYGRKAFKRSRSHFADRITADGRDGWPVEPGRYR
                     LVVSRACPWASRALVSRRLLGLEDALSLAVADPVQDDRSWRFTLDPDGRDPVLGIRFLS
                     EAYDRRETGYPGGVSVPAVVDVPSGKLVTNDYQQITLDLATEWAALHRPGAPDLYPEAL
                     RAEIDEVMAGVYEDVNNGVYRAGFATGQEEYEAACTGVFRRLEQLAPRLEGQRYLVGDT
                     ITEADIRLFTTLVRFDAVYHGHFKCNRWKLTENPVLWAYVRDLFQTPGFGDTVDFDHIK
                     RHYYQVHTGINPTGIVPLGPDLAGWLTPHHREELGGRPFGDGTPPGPVRAEEEVPARGR
                     P"
     gene            13275..14270
                     /locus_tag="EZV63_RS33675"
                     /old_locus_tag="EZV63_34145"
     CDS             13275..14270
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978085.1"
                     /locus_tag="EZV63_RS33675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34145"
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_224220398.1"
                     /transl_table=11
                     /translation="MSESASEQKPGRDGESRADRRTRVTVLVALAANLVIAVAKAVGGF
                     FAGSPALLSEAAHSVADSMNEIFLLAALRRSRRPADRRHPFGYGKERFFWSLLAAVGIF
                     VMGGCFSFFQGVEALRSGAEEELSGYVAGLIVLGVALLAEGASLLRALHQVRGQGGLAT
                     GLRDPALRTVVAEDGTAVLGVTLAMIGMVLHMVTGQVVWEACASLAIGALLVYVAYRLG
                     REARDQLIGEAADPEADGRIRELLRAQPEIDSVEALFTMKTGLDSALVAARVDLVPGLD
                     SEEVEEAAVRIKRSIAHTVPEAGQVFLDVTDRPAREAAQSPAATGERGGA"
     gene            complement(14335..14784)
                     /locus_tag="EZV63_RS33680"
                     /old_locus_tag="EZV63_34150"
     CDS             complement(14335..14784)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978086.1"
                     /locus_tag="EZV63_RS33680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34150"
                     /product="nitroreductase family deazaflavin-dependent
                     oxidoreductase"
                     /protein_id="WP_037766815.1"
                     /transl_table=11
                     /translation="MPLEGEYEPSPTQWVRDQVELYEGSGGTEGTTHPDTGLPVIVLTS
                     RGARSGKIRKTPLMRVEHDGRYAAVASLGGAPKHPVWYFNVLAEPHVELQDGPRKRDMT
                     AREVTGAEKAEWWERAVAAYPPYADYQKKTGREIPVFVLEPADAG"
     gene            15171..16385
                     /locus_tag="EZV63_RS33685"
                     /old_locus_tag="EZV63_34155"
     CDS             15171..16385
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978785.1"
                     /locus_tag="EZV63_RS33685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34155"
                     /product="cytochrome P450"
                     /protein_id="WP_070389894.1"
                     /sec_met_domain="p450 (E-value: 6.3e-26, bitscore: 89.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTTTDPDTTRPVAYPQDRTCPYHPPAAYDPLRSGPPLAPITLF
                     DGRPAWLVTGHTLARRLLVDQRLSTDRTRDGFPLTSPRLAGIRSRRLALLGVDDPEHRA
                     QRKMVLPEFTLKRAAALRPRIQEIVDERLDAMIAAGQPADLVPAFALPVPSMVICALLG
                     VPYADHEFFEEQSRRLLRGPLPADVRDARDRLESYLGELIDGKRTSPGDGLLDDLIRDR
                     LEEGEIDREQLISFAVILLIAGHETTANMISLGTYTLLENPGRLAELREDPALLPGAVE
                     ELMRMLSIADSLLRTATEDMEVEGHTIRAGDGVVFSTSVINRDGTVYPEPDAIDWHRPA
                     RHHVAFGFGIHQCLGQNLARAELEIALRALFERLPTLRLAVPAQEIPHKPGDTIQGMLE
                     LPVAW"
     misc_feature    complement(16393..16403)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            16410..16610
                     /locus_tag="EZV63_RS33690"
                     /old_locus_tag="EZV63_34160"
     CDS             16410..16610
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027347.1"
                     /locus_tag="EZV63_RS33690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34160"
                     /product="ferredoxin"
                     /protein_id="WP_031031916.1"
                     /transl_table=11
                     /translation="MDIGIDKDVCIGAGQCALTAPDVFTQDDDGYSTLQAGREDGGGSP
                     LVREAARACPVGAITVSERVG"
     gene            16760..17305
                     /locus_tag="EZV63_RS33695"
                     /old_locus_tag="EZV63_34165"
     CDS             16760..17305
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979463.1"
                     /locus_tag="EZV63_RS33695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34165"
                     /product="flavoprotein"
                     /protein_id="WP_031031913.1"
                     /sec_met_domain="Flavoprotein (E-value: 1.9e-10, bitscore:
                     39.4, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDGEPGGSKGAPFLYVVVCAAGVASGVGALIDAALRRDWEVGVF
                     ATPVAMDGFFDTADVEARTGRPIRSAWRRPGEPRPFPAPDAVVVAPATFNTVNKWAAGL
                     ADTLAVATLCEACGLGVPVGVLPCVSDALASHPAYRASLDRLRGMGVRFGDPYEGGAAA
                     GGDRRFHWERALDLLERR"
     gene            17384..18352
                     /locus_tag="EZV63_RS33700"
                     /old_locus_tag="EZV63_34170"
     CDS             17384..18352
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978092.1"
                     /locus_tag="EZV63_RS33700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34170"
                     /product="aldo/keto reductase"
                     /protein_id="WP_031031911.1"
                     /transl_table=11
                     /translation="MQYVKLGSTGLDVSRICLGCMTYGVPGRGAHEWTLDEDAARPLIR
                     QALEAGVTFFDTANVYSDGTSEEIVGKALRDFARRDDIVLATKVHGRMRPGPNGAGLSR
                     KAIMTEIDHSLRRLGTDHVDLYQIHRYDPHTPIEETMEALHDLVKAGKVRYLGASSMYA
                     WQFSKAQYTAERHGWTKFVSMQNHYNLVYREEEREMLPLCADQGVGVLPWSPLARGRLT
                     RDWDTATGRSATDAFGSTLYPEGDRAVVEAVTRIAGERGVPRAQVALAWLLHQDTVTAP
                     IVGASKPGHIEDAVAAVELVLGEKEIEELESPYTPHPVAGH"
     gene            complement(18396..19061)
                     /locus_tag="EZV63_RS33705"
                     /old_locus_tag="EZV63_34175"
     CDS             complement(18396..19061)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027343.1"
                     /locus_tag="EZV63_RS33705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_34175"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_037766810.1"
                     /transl_table=11
                     /translation="MANTSQPVRRTALLAGGLAVLGLLSACGSENGTSGTPPPSHSARA
                     SDAAPSAGTGTATDPGTAAAAGTPSDTAGSASASARTDGRCHTSELRAAVGRLDPGAGQ
                     RNFPLVLTNTSERTCTVYGYPGAAFVDASGKQLGPDPERAPGSPEPLTLTPGASAWAGL
                     SFSSPEISGARTATPAALLVTPPDERASLKVEWTAGAVPVGGNASSVSVTALEAGSGP"
     misc_feature    complement(20093..20107)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.0"
                     /tool="antismash"
     misc_feature    20325..20339
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
ORIGIN
        1 cgcagtccgt ccgcgccgag gtcgccgagg acccgcgccg cggcgcggaa ggcgcgcacg
       61 cggtacgtgg gtgcctggga ccgttccagc aggaacgcga tccgctccag tgcctcgacg
      121 ggatccatcg ccaccacctc cggccggccc tcgcggcggc tcctccgcca cgtccagggt
      181 tccccagggg cccggggccc gcaccacgga cacggcgccc ggcgccaccc gcggcctacc
      241 ctctagacat gaccgaaatc gacagcccgc acatcggcag cccgcggatc ctcgtactcg
      301 gggtgcagcc ggggacgccc ccgttccgga tcgtcgagat cgacggccag gtggccggtg
      361 cggccaggga cgtcaccgac gtactggagg cggccgcggc cttcggcatc acggtccacg
      421 acctggacga cccggacgtg gtccgctggg tgggcgggga caagttcacc tggacccggc
      481 gctaggaggt gtccgggccg gccccgcccg gtggctcagc cgaccgtcca cttctggttg
      541 gcggtgcccg cgcaggtcca gatctgcagc cgggtgccgt tggccgagtt gttgccggtg
      601 acgtcgaggc acttgtcggc ctgcggattg acgatgtcgc gcgccgcggt gacgacccac
      661 tgctgcgcgg cgctgccgtt gcagtcccac agctggacga ccgtgccgtc cgccgtgccg
      721 ccggcgttca cgtccaggca cttgccgagc gcccggatcg tgccgtcgga gcccaccgtc
      781 cactgctggg ccgtggtgcc gttgcagtcg tagagctgca cgggcgtgcc gttggcggtg
      841 tccgccgcgg cgacgtccac gcacttgccg gccaggcccc ggatcgcgcc ccctgccggt
      901 gagtcgccgg tcgtcaccga gacgtggtcg acgaccaggg tctgggggaa gaccgtggag
      961 ccgtccgggt cgcccggcca gtagccgccg accgccaggt tcaggatcag gaagtacggc
     1021 ctgttgaaca cccactgcct gccgcccagg tcggccgggg tgcgccgctg gtagacgttg
     1081 ccgtccaccg accaggtgac cgagtcgggc gcccagtcga cggcgaaggt gtggaaggcg
     1141 tccgcgaagg cctggccgcc cggcaaggtg tacccggcgc cgatgccgcc ggcgccggag
     1201 tagccggggc cgtgcagggt gccgtgcacg gtggagggct cgaagccgac gttctccatg
     1261 atgtcgatct cgccggagtc cggccagttg accggggtgc ccagcatcca gaacgcgggc
     1321 cacatcccct gcccgcgcgg caccttcatc cgcgcctcga cgtgcccgta ctgcgccgtg
     1381 aacttccccg aggtgttgag ccgggcggac gtgtactggc aggtgccgta ccagcactgg
     1441 tagttggccg ggttctcctt gcgggccgtg acgaccaggt ggccctggcc gtccagggcc
     1501 gcgttcttgt tgccggaggt gtagtactgc cgttcgtggt tgtcgacgtt gtcgccggtc
     1561 tcgatctgcc acttcgagga gtcgacggcc gcgccggccg ggccgtcgaa ggtgtcggag
     1621 aagaccacgg cggcggccga ggcgccggcg gtcgcggggc cttcgggctc cgcctgggcg
     1681 gggccggtca cgagggacgc ggcgagcccg gcggacaggg cggcggcgag gagacatctg
     1741 cggagcaggc gtgggcggac cacggctctc ccttccgtac ggcgctccgc gggggagcgc
     1801 cgaccgaggt gggggtggag tggggatgtc gcctctttat tcaaatagtg aggtaagggg
     1861 tggtcaatac attggtacgg accagaagcg ccgtctcagt cccgggcctt gcgcgcgtgc
     1921 accgaccggc tcatccgccg gccgaggagc aggtaaccga tcagcgcacc actcgtgttg
     1981 aggatgacgt cgtcgacgtc gaaggcccgc ccggtgacga gcgcgccctg cgcgaactcc
     2041 accagcagca tcaccacggc cgtcagcagc agtacccgca gcaccccgcg cgtgcgcggc
     2101 gccacgaccg gcacgagcac gccgaacggc acgcccagca ggatgttccc gccgatctgc
     2161 ttcacggcgt cccgcagggc gggctggtcc aggtaggccc tcagtgagct gcccggtcgc
     2221 atgttggtgt gcgtcagggc ctcggaggcg ggggaggggt gcagggtcag ccgcgccagc
     2281 accaccgcga acgccaccat gaagacgaac gcgcacgccg tggccagcag ccgcaacggc
     2341 agggcgagcg cgtgccgttc gggtgggtcg gccttccgcg cctcggcggc gcgggggcgc
     2401 ggccacagtc gcaatcctga gacggcacga gccatgtcgg tcctccagtc gtcaacgtcc
     2461 ccgcgtggaa gggcggttac ccgccgcgcc gccgaggatg cccggcaatg cgcaacgggt
     2521 cgtatccgct ccgcccgccg ccatccgcgc ggtcctcgga cggcggtgcg tccggaacgg
     2581 acagggacaa gaatggacaa aggcaagggt gatgcgaggg gcggccccgg accgggcgcc
     2641 ggggccggcg cgccctcccg cccgcggagg gctcagccct tgtatgccac ccgcacctca
     2701 tcgaagccca gggagcgcag caggccctgg agcatcgccg tggtgttgct ctcggcccgg
     2761 gtcttcagct cgctgtcctt cgccgcctcg ccgatgtgcc gggacgcgag cttctgcacg
     2821 gcctgctcac cgttcgggtt gtccgagaac aggtcgccca ggcggtccag gagcccgcgc
     2881 tgcttggaga ccgcgtagga gcggtcgggg tcgagggccg gctcgccgag cgccgcgtgc
     2941 ggcagccgca gcgtggccga cgtccggtcc ccgtcgacct gcacgtcgtc ctcgcccagc
     3001 ttcccgaggt cgacataggc gtccacggtg cccgccccca cgtacagggt gcgggtcccg
     3061 cggatcgcgt ccggcaggaa cttggtgtcc ttctccaggt ccacgacgac ctggaagttg
     3121 ccggacgccg cgtcgtaacg gctcatgtcc tggatggact tcagcagcgc cggtccggac
     3181 cggtcctgcg tctccgagcc gaacaggtcc ttgaggccgg gcaggacact cagccggagc
     3241 ccggcgaaca gcaccgcgag caccagcacc accgcggtca gcgccttcgc ccagccgggc
     3301 atgcgcggcg cgggcttccg gtcgtcactc gtgggcttct tgacgggagt cgtcatggcg
     3361 acggccctcc ttcctactca cccggatgcc cctcatctcc cgtgccagac cgagcagttg
     3421 gagaacgggc ggcaggacgc gggcatcccg ggtgatttgc ggctgccggg gctcacccgc
     3481 ggggaggcgg tgtggtcctc gcgaccgtcg acggccacct ccgatgcacc gtcggccgaa
     3541 accgtgacgg ccgcaccggt tcaccgtcag ccggacaccg tgacggccgc cgggtccgtg
     3601 tgccgcgtcg gtggtggtgt gccggtcagc accccgttcg gcgagcggtc ggcagggcgg
     3661 ggccgagtac ctcccgcagg gtcggccgcg gtggcagcag ccgggtcagg ccggtgatcc
     3721 gcagcatgcg cagggtgagc gggtgcgagc acaccaggtg cacctctccg ccgcccgcga
     3781 gcacctggtt gcgggcccgg gcgagcagcc ggaccccgga gcagtcgaag aactcgatcc
     3841 cgccgaggtc gagcacgaca cgggcgccgg ggcgccgcgt ctcgcggtcc aggcgcggag
     3901 cgatctccgt ggcggacgcg atgtcgatct cgccccggaa ctccagcacc gcgtgcccgc
     3961 gctcgtggcg cacccgcaga tggcgggtgg gcgacgggga ttcctgccgc acgacgacgt
     4021 cgcctccagc ctgttccggc ccgttccggc ctgtcatggg agcccaacta cccgttctgc
     4081 tcagaaagtt acctcgggcg agcgagtttg agcatgttcg actgacatat gtcgccgacg
     4141 tctcatcgca cggccgtgcc gaccgttcag tcgaccacga gaacgatctt gccggtggtg
     4201 cggccggtct cccccagggc gtgcgccccg gccgcctcgg ccagtgggaa cgtcttcgcg
     4261 atggtgggct ccagcttccc cgcctcgacc agccgggcga tctcccgcat gtcggcccgg
     4321 tcggcgtcga ccagcatccg caccgcccgc accccgagcc gcccggcctc ctcgaagaac
     4381 tcgccggacc cgaccggcag gatcgacacc accaccccgc ccgggcgcag cacgcgcagc
     4441 gaccgcagcg acgtgtcgcc gccgatcgtg tccaggacga cgtcgacgtc gcgcaccgcc
     4501 tcggtgaagt ccgtctcccg gtagtccacg gcctcgtccg ccccgaggga ccgcaggaac
     4561 gcgtgcttgc ccgcgctggc ggtgccgatg acgtgggcgc cccgcgcctt ggcgatctgc
     4621 accgccacgt gccccacgcc gccggccgcc gcgtggatca gcacccgctg ccccggctgg
     4681 aggtccgccc gttccaccag ggcctgccac gccgtgaggg acaccagcgg gagcgcgccc
     4741 gcccggacgt ggtcggtccc ggccggcagg tgcgtgaagg tgcgcgcggg agccgtcacg
     4801 tactccgcgt gcgaaccgtg gccgaaggga taggagagca tgccgaagac ctcgtcgccc
     4861 ggccggaacg cggcgacgcc gatccccacc gactccaccg tgcccgagac gtcccagccc
     4921 agtacgaagg gcggctcgcc gaggaagccg ccgtccgccc ggtgcttcca gtcggtgggg
     4981 ttcaccccgg cggcacgcac ccggaccagc acctcgttcg gccgcggtac ggggcgctcg
     5041 acccgtacct ccttgaggac ctcgggtccg cccagaacgt cctggctgac ggcgcgcatg
     5101 gtggtcatcg gagaacctcg caactcggga gggggtcagg ggcacggtct gcggctccga
     5161 cgtgatcgtg ccattccccg ggccggacgg cacccgcggg cgcggcggcc ggatcagggc
     5221 ggcgggcgtg ctcaggcccc ggtttcccgg gcgcgccctg tcggcgctcc tggtcaattg
     5281 ggggatttgt cgacctccgg cccgctgccg ggtcgtgacg gaatcctcac ttccgcagag
     5341 ccgtgaaatt gatcttttag gcttcccaac cgataagctc cccagcggca ctgcgagttg
     5401 acgcgatcgc gacgggtcgg cccgtggtgc acaccctgag tgcggtcccc ttgcgcaccc
     5461 ttgctcgacc atcccccctg ttcgattgtt ttgcttcgaa ggatgcagat ggaactcgcc
     5521 actccgccac cggcggcgcg ggtccctgtc gcctggcaca gctggtggct catgccactg
     5581 gggctgggcg gcgggacggt agccgccacg ttcatgagct cggagcgaat aaccgtggcc
     5641 gtcgccggcg cggcggccac cgtggccggc accgtgtgcg tacgccttct cctgcgcacc
     5701 cgcgcccagc tgggccgggc cgagaacgcc caccgttccg cgcgctccga gaactcccag
     5761 cagtggcagc agcacgtggc cggcctggaa cgcaagttct ccgccgagcg ctccgacctg
     5821 gacgcccagc tcaccgagca ggcccagacc tacgaggaac ggctcgccga gcacacccgg
     5881 gcctacgagg accggatcgc cgagcaggcc acgtcctacg aggcccggtt cgccgagcgg
     5941 accgaggcct ggcaggagca gctgggacac cagctggccg cggtgtcccg gctcgccgac
     6001 gagcagttgc ccgacgcgat gcgcagactg cgctccggtg acgccatcga cgacatcctg
     6061 ccgaccgtcg agcagtgctc caaggtcggc gccgacctcc aggccgaact gcgcaaggtg
     6121 ctccggaccg cgctgatcgg cgtcgaggcg gagttcgacc gctcgacctc cgcggagcag
     6181 gcggtcatca gcgtcggcaa ccgcatccac gtgctgacca gcaagctccg tggccgcctg
     6241 cacgagatgc agggcgagca cgggcggctg cccaccgtcg cccgcggcct gatggaactc
     6301 gaccaggcca tcggccccgc ggactgcctc gccgccagca tcggcgtgct cggcggctcg
     6361 gaccgcccgg gacggcagtg gcaggaaccg cagcggctgc tgagcgtgat gcgcggcggc
     6421 atcggccgga tcaaggactt ccaccgcgtc cagctgcgcc acctgcccga actgggtgtc
     6481 gacggcggcc tggtggacca cctcacgctg atcttcgccc acctgctgga caacgccgcg
     6541 cgctactcgc cgcccaccga gccggtggtc gtctccggca aggaggtgcc caacggcgtc
     6601 ggcatcgaga tccaggactc cggcaagggc ctgagcgacg agaagaagcg cgaggccgag
     6661 cacgcgctgg ccggcacctc gcccggtgcg ggactcggcg gcatctcgga ggacgccaac
     6721 atcggcctcc gcgtcgtcgg cgccctcgcc cgccgctacg gcatccgggt caccttcgcc
     6781 gactcgccgt ggctgggcac gtccgtggtg gtcgtcgtac cccacaagta cttcagcccg
     6841 ctgccgtccg ccgcggcccc cgcgaccgtg ccggacaccg cgcaggccgt caccgccccc
     6901 gcggcggacc tcgtgccccc ggcggtcgtc gaggcggcag ccgcccccgc accggcggtc
     6961 gagtccacac gggcggccga ccccgcgccc gcggccgacc ccgcggtgga gaccaccccc
     7021 ggaggcctgc cccgacgccg gagcaggcgt gccgaaccgg ccgccccctc cggggccgcc
     7081 gcgccgaccg cgcagccgcc cgggagcgaa gccgccgacc gggcccaggc ctccgccgtt
     7141 ccaccggacg cgtccttcac cggtctcgcc gccttcgcca ccgcgggccg cgaccccggc
     7201 gccggcacct ccgaatcgac caccggtggc gcgtccaccg agcaccgcac tgaagagagc
     7261 gactagtccc catgacgcac cagggaaccg acgtgagctg ggcgctccgc gaccttgtgg
     7321 agagcatcca ggagatccgc ttcgccctcg ttgcctccag cgacggcaag gcgatcactt
     7381 cctacggcgc cgaagacccc gacgacgtgg accgcttcgc cgccgtggtg gccggcctgc
     7441 aggcgctggc ccagccggtg gccgagcagt tcccgcagca cgcggggcag ctgcggctgg
     7501 cgatgatcga ggtggacggc gggcacctgt tcgtcgtccg ggcgggcatg gagacgtatc
     7561 tcggcgtcct cgcccgcgaa ggactcgacc agggcctgct gggccatcag atgcgcgacc
     7621 tggcccgccg gatgggtgaa ctcctcggga ccacgccgcg ccaggaggag cactctggat
     7681 gagtgctccc cgccgaccga ccgatccgtc cggtctcgag cgctactacg tcctcaccgg
     7741 agggcgcagc gggccgggcg gttcggcgtc gaccctcgac gtggcgacgc tcgtcgtcgc
     7801 gcgtgccgcc cccttaccgg gcatgcagca cgagcacgag gagatcctcc ggcgctgccg
     7861 cgacccgctt tcggtggccg aactcggcgc ccatctgcac ttgcccttca acattctcgc
     7921 ggtgctgctg tccgacctgc tccaggcggg cagcgtcgaa gcccgtgatc ccatcccggc
     7981 actggatgcc ggccgcgggc ccgacctcgc gctccttgag gaggtactca gtggacttca
     8041 aaggctttga ccgaccgggg tcatccacgg cgggggacac ccgctcggtg aaggtgatga
     8101 tcgccggcgg cttcggaacg ggcaagacca ccatggtccg cgccgtcagc gacatcaaac
     8161 cgctgaccac cgaggagacc ctcacccagg ccagcgccga cgtcgacccc ctcatcgggg
     8221 tggccgacaa gacgcagacc acggtcagcc tggacttcgg caagatcggc ctcaacgaga
     8281 cgctgatgct gtacctgttc ggcaccccgg gccaggaacg cttctggttc ctgtggaacg
     8341 gcctgttcaa gggcgccctc ggcgcggtcg tcctggtgga cacccggcgg ctggcctcca
     8401 gcttccgggc gatcgaggag atggagcggc agaaggtccc cttcgtcatc gcgctcaacg
     8461 tcttccccga ctcgcgcgac tacccggtcg acgagatccg cgacgccctg gacatcgcgc
     8521 cgcacacgcc ggtcgtcgcc ttcgacgccc gtgaccccac agccggccgc gacgtgctgg
     8581 tcaccctgat ccgtcacctg aaggaccgct cggccgccgc cctggagccc cgatgaacga
     8641 cgaccagacc ccgtccgccc ccacgggcgg cggctgcccc gtcgcccacg gcgagggcgc
     8701 cgtccggctc tacggacccg acgcggcgac cgacccgcac gagatctacg cgcggctgcg
     8761 gggcgagcac ggggcggtcg cgccggtact gctggaggac gacgtccccg cctggctggt
     8821 gctcggctac cgggagaacc ggcgagtgct ggacaacccc ctccagttca gccgcgactc
     8881 gcggatctgg cgggacttcc aggacggccg ggtcgcggag acggcgccgc tgatgcagat
     8941 ggtggggtgg cggcccgact gcgtctccca ggacggcgaa ccgcaccgca ggctgcgcgg
     9001 cgcggtcacc gacaacctgt acgccgtcgc gggacgcggc atccggcggc acatcacgca
     9061 cttcgccaac aagcagatcg acgcgttcgc cgacgcgggc cgcgccgacc tggtggccga
     9121 cttcgccgag tacctgccca tgctggtcct cacccgggtc ttcggcctcg ccgagcggga
     9181 gggacgcacc ctcgccgagt ccagcaacca ggtgatcaag ggcggcgcgg acgccctcac
     9241 gcacaacgag cgcatcatgg gcatcctggg cgaactcgcc gagcgcaagc gcagggagcc
     9301 ggggtccgac ttcgcctccg gtctcatcga gcacaactcc ggcctcgacg aggacgagat
     9361 cgtcaaccac ctgcgcctgg tgctgatcac cgcccacacc acgaccagca acctgctggc
     9421 ccgggtgctg cagctcgtcc tcaccgactc cgcccggctg tccggcctgg tgagcgggca
     9481 gctgaacatg tccgcggtgg tggaggaggt catgtggaac tccccgccgc tcgccgtgct
     9541 gccgggccgg ttcgccaccg ccgacctgga actgggcggc tgtcccgtca aggagggcga
     9601 cctgctcgtg ctgggcctca cggccggcaa ccacgacccc gagatccgcc ccgacaccgg
     9661 cgtctcggtc gagggcaacg cctcgcacct cgccttcagc gcgggccccc acgaatgccc
     9721 ggggcagaac atcggccagg ccatcatcga gacggccgtc gacgtcctgc tccaccgcct
     9781 gccgggcctg cgcctggccg tgccggcgtc cgagctgacc tccacggcct ccacctggga
     9841 gtcccggctg gacagcctgc cggtggagtt cgcccgatag ccaaacggga ccgagcgaaa
     9901 gccgcgggac cgagcgaaag ccgcgggacc gagcgaaagc cgcgggaccg agcgaaagcc
     9961 gccgcccggc cggaacaccg gccgggcggc ggctttcgtc ctacacgccc agcaggtcgt
    10021 ccaccgagcc ccgcccggcc tgttcggccg tggcgaccgg gccgtccttg gccgccgcgt
    10081 agcgaccggt cgtcagcgcc cactcgtagt tgccgttgat ccagtgctgg atggcctcca
    10141 cacccagccg cacccgcgtg cgcccgtcgc cgtcgagacc cagctcgtcg cacatctgcg
    10201 gcacgcgcgc ctccagggcg acgtactcgt cgaggcagtc ggtcgtcatg cggtacgcct
    10261 cctccgccgc ctcctgccag gagcagcccc gctcgcgctg cagcacggcg acgaggttgt
    10321 gcccgtcgcc gcggcggcgc tcgcgctcga aggagtggat gtcgttcatg aacccgatgg
    10381 tgtccgcggc caggtcccgc atccgctcca tgagggggtg cgccatcgcc gcggccggca
    10441 cctcgaagcc gcggctgcgc tcgcccgcgt cgatgctgtg gtggatgccg accgtgcggc
    10501 gccggaagac ggcgtactcc tcgatcccca gcgtggcggc ccggccgtgg gccgccaggt
    10561 cgacctcctc gcagtgcgcc accaggaacc ggccccagga cgccgcgaac cgggacttcc
    10621 acgtcaggga catgccatcc gaaaggtgac cccagacctc cgcccacgcc agcgtgatgg
    10681 ggcactccac gcgcggcggg gtccccgccg gacgcagcgg cgtggcgatg agttcccggg
    10741 ccacctcggc tatgcgctcc gcgcggtccg gccgggcggc gtcgaactgg tcgtcgaaga
    10801 ggaaggccag cgagaaccag ttcatcagga cgaccatgtc gtcggccgac gcgtgcgggt
    10861 aggtgcgggc ggcggcctcg gagaggtccc aggagcggta ctcctcgaag cccgccgcgc
    10921 tgcgcaccag cccccgctcg cgcacccagc gcagatggcg ctcacgggcg tgcgcgagat
    10981 gcgggctgac gggggtgtcg aaggggaggt cgaagcggac gtcctgcatg tggttccttt
    11041 cgggagacgg agcgcagagt ccccccggcc ctgcgagcgg acggcggcgg ggccgtccgc
    11101 gcactcgaac tcggcttcac ggaaagaaag ttgaaccgag aagcgatacg aggctgcccg
    11161 taccctaaat gatctacacg gcgtccgctg gtgatctccg ttactcccgg ctccgccggg
    11221 tatccgcaca gtacgaggtg tggggcagac cgccccacac ccggcatctc cggaggggaa
    11281 cgagacgaca tggcactggt caacgcgggc gtcgtggtgc tcgactgcgc cgagcccgag
    11341 cggctcgcgg agttctacaa gggcctgctg ggggcggagg agacggacgt gaccgccaac
    11401 cggatcgaga tcgaggggcc gagcggcttc cgcctggcct tccggcggga cgtgaacgcc
    11461 accccgccca gctggccccg cccggagaat tcgctccagg tccacctgga cctcgtggtg
    11521 gcggacctgg acgaggccga gcgcgcgatc gtcgggctcg gcgggcggcc ggtggaggcc
    11581 aaggacgcgg cggggccgca cgaggaacgc ggcttctccg acccggcggg gcactccttc
    11641 accctgcgcc tggccgtcgc gccgacggca cccaagcagg gctgaacgcg gcctgccggg
    11701 tgccgtcgcg gcgggggagg ggcggtgcgg tcagtcccgc ccgcccctgc cggggatcgg
    11761 ccaggtgccg gtggagcgcg cgatggcctt cgcgccggtg cggtccacgg cactgcgcac
    11821 cgccgcgaag atggcgccct ggatcgcggc ggccagcagg atctcccccc agccgcggtc
    11881 cgggtcgagc gcgtcgggcg cgtcgtcctc gtcccggatc agcttccagg tcttctggaa
    11941 cgccagtccg gccagcgtgc cgcccagcca cccgagcgcg aagcccaccg gtttgtaggc
    12001 gagcgggagc ttcttcttct ttgtcttcgc catgcggatc tccttgcgcg ctgtgcgatg
    12061 tgcagcgggg aaacggtgga agcggtggaa gcggtgggac ggcgctggaa cgggacggcg
    12121 gtggaagggg tcagggcctg ccgcgcgccg gcacctcctc ctcggctcgg accgggcccg
    12181 gcggcgtccc gtcgccgaac ggccggccgc ccagctcctc gcggtggtgg ggcgtgagcc
    12241 agcccgccag gtccgggccc agcgggacga tgccggtcgg gttgatgccg gtgtgcacct
    12301 ggtagtagtg ccgtttgatg tggtcgaagt cgacggtgtc cccgaaaccg ggcgtctgga
    12361 acaggtcgcg gacgtacgcc cacagcaccg ggttctccgt cagcttccag cggttgcact
    12421 tgaagtgacc gtggtagacg gcgtcgaagc ggaccagcgt cgtgaacagg cggatgtccg
    12481 cctccgtgat cgtgtcgccg accaggtagc gctgcccctc cagtcggggc gccagctgtt
    12541 ccaggcgccg gaagacgccc gtgcacgccg cctcgtactc ctcctggccg gtcgcgaagc
    12601 ccgcccggta cacgccgttg ttgacgtcct cgtagacgcc cgccatgacc tcgtcgatct
    12661 cggcgcgcag cgcctcggga tacaggtcgg gcgcgcccgg ccggtgcagg gcggcccact
    12721 cggtggcgag gtccagggtg atctgctggt agtcgttggt gaccagcttc ccgctgggca
    12781 cgtccaccac cgccggcacg ctcaccccgc ccgggtagcc cgtctcccgg cggtcgtagg
    12841 cctcactgag gaagcggatg ccgaggaccg ggtcgcggcc gtccgggtcc agggtgaacc
    12901 gccagctgcg gtcgtcctgg accgggtcgg cgaccgccag ggacagggcg tcctccaggc
    12961 cgagcagccg ccgggagacc agggcccggc tggcccacgg acaggcgcgg ctgaccacca
    13021 ggcggtagcg gccgggttcc accggccagc cgtcccggcc gtccgcggtg atccggtccg
    13081 cgaaatggct ccgggaccgc ttgaaggcct tcctgccgta accgctgttg cccggcgtcg
    13141 cgtcgtcgcc gctcatgggt ctgcctcccg tcgttcgtct gccactggac gcgttccccg
    13201 ttttcggccg tcggcactgg cgggccaccc gcacggcggg tgtgaggggc gcggccgggg
    13261 gcagtcgggc cttcgtgagt gagtcagcct cggaacagaa acccggccgc gacggcgaga
    13321 gcagggccga tcgcagaacg cgcgtcaccg tgctcgtggc cctggccgcc aacctggtca
    13381 tcgcggtggc caaggccgtc ggcggcttct tcgcgggctc accggccctg ctgtcggagg
    13441 cggcgcactc ggtggccgac agcatgaacg agatcttcct cctcgccgcc ctgcgccgca
    13501 gccgccggcc cgccgaccgg cggcacccct tcggctacgg caaggagcgg ttcttctggt
    13561 cgctgctcgc cgccgtcggc atcttcgtga tgggcggctg cttctccttc ttccagggtg
    13621 tcgaggccct gcgctccggc gccgaggagg aactgagcgg ctacgtcgcc ggactgatcg
    13681 tgctcggtgt cgccctgctc gccgagggcg cctccctgct gcgcgccctg caccaggtac
    13741 gcgggcaggg cggcctcgcc accgggctgc gcgacccggc gctgcgcacg gtggtcgccg
    13801 aggacggcac ggccgtgctc ggcgtcaccc tcgccatgat cggcatggtc ctgcacatgg
    13861 tcaccgggca ggtggtgtgg gaggcctgcg cctcgctcgc catcggcgcg ctgctcgtgt
    13921 acgtggccta ccgcctgggc cgcgaggccc gcgaccagct gatcggcgag gccgccgacc
    13981 ccgaggccga cgggcggatc cgcgagctgc tgcgggcgca gccggagatc gacagcgtcg
    14041 aggcgctgtt caccatgaag accggcctcg actccgctct ggtggccgct cgcgtcgacc
    14101 tggtgccggg cctggacagc gaggaggtgg aggaggccgc ggtgcgcatc aagcggtcga
    14161 tcgcccacac cgtgcccgag gccgggcagg tcttcctcga cgtcaccgac cgccccgcgc
    14221 gggaggcggc gcaaagcccc gccgcgacgg gggagcgcgg cggggcctga ccgtcgtgtg
    14281 cccggcacgc gacggtccat gccgtcgggt ccgggagaag tcccgtgcgc cgggtcagcc
    14341 ggcgtcggcc ggctccagga cgaagacggg aatctcccgg cccgtcttct tctggtagtc
    14401 cgcgtacggc ggatacgccg cgaccgcgcg ctcccaccac tcggccttct ccgcgccggt
    14461 gacctcacgg gccgtcatgt cccgcttgcg cggaccgtcc tggagctcca cgtgcggctc
    14521 ggccagcacg ttgaagtacc agaccgggtg cttgggcgcc ccgcccaggg aggcgaccgc
    14581 ggcgtaccgg ccgtcgtgct cgacccgcat cagcggcgtc ttgcggatct tgccgctgcg
    14641 cgcaccccgg ctggtcagca cgatcacggg caggcccgtg tccgggtgag tggtgccctc
    14701 ggtgccgccc gagccctcgt acagctcgac ctgatcccgg acccactgcg tcgggctggg
    14761 ttcgtactcg ccctcaagag gcatctgtgc atccgtccca tcgtcgcgtc gtcggaccgc
    14821 ccggccggtg cggaccaccg ggccggtgcg gaacccgtcc gtccatcctg catcctgccc
    14881 tgtacccccg aacaccgcgc ggacatccgg agcgggcgcg tccgttcgac ggccggaaca
    14941 ggacgttccc ggccgcaccc ggggaccggg tggtcccgcc gaacgacgtg atcaggccac
    15001 gcccaccgtc cgtcgcggcc gcggcgaagg cctcggacgt ccctcacccg gcggtccccg
    15061 gccactctgc ccacgccacc ggtctggccg aacttgacgt cgccatatag gtgcccaggg
    15121 catctaattt agctcggcac gaggcaccga tttcgtctgc gaggtcttcc atgacggaca
    15181 cgacgactga cccggacacg acgcgacccg tcgcctaccc gcaggacagg acctgcccct
    15241 accacccgcc cgccgcctac gacccactgc gctccggccc gccgctcgcc cccatcaccc
    15301 tgttcgacgg ccgcccggcc tggctcgtga ccgggcacac cctcgcccgc cggctcctcg
    15361 tcgaccagcg gctgtcgacc gaccgcaccc gcgacggctt ccccctcacc tcgccccggc
    15421 tggccgggat acgcagccgt aggctggccc tgctcggtgt cgacgacccg gaacaccgcg
    15481 cccagcgcaa gatggtgctt cccgagttca ccctcaaacg cgccgccgcc ctgcgcccgc
    15541 gcatccagga gatcgtcgac gagcgactcg acgcgatgat cgcggcaggc cagcccgccg
    15601 acctggtgcc ggccttcgcg ctgccggtgc cctccatggt gatctgcgcg ctgctcggcg
    15661 tcccctacgc cgaccacgag ttcttcgagg agcagtcccg gcggctgctg cgcggcccgc
    15721 tgccggccga cgtgcgcgac gcccgggacc gactcgagtc ctacctgggg gagctgatcg
    15781 acggcaagcg gacctcgccc ggcgacggcc tgctcgacga cctcatccgg gaccggctgg
    15841 aggagggcga gatcgaccgc gagcagctca tctccttcgc cgtgatcctg ctgatcgccg
    15901 gccacgagac caccgccaac atgatctcgc tgggcaccta cacgctcctg gagaaccccg
    15961 ggcgcctggc cgagctgcgc gaggaccccg cgctgctgcc cggcgcggtc gaggagctga
    16021 tgcgcatgct gtcgatcgcg gacagcctgc tgcggacggc caccgaggac atggaggtgg
    16081 aagggcacac catccgggcc ggcgacgggg tggtcttctc gacctccgtc atcaaccgcg
    16141 acgggaccgt ctacccggag ccggacgcca tcgactggca ccgcccggcc cgtcaccacg
    16201 tcgccttcgg cttcggcatc caccagtgcc tgggccagaa cctcgcccgc gccgaactgg
    16261 agatcgccct gcgcgccctc ttcgagaggc tgcccacgct gcgcctggcc gtacccgccc
    16321 aggagatccc ccacaaaccc ggcgacacga tccaggggat gctggaactc cccgtggcct
    16381 ggtaggaggg tcgggacatg gcaacgggca tggacatcgg tatcgacaag gacgtctgca
    16441 tcggcgccgg tcagtgcgca ctgaccgccc cggacgtgtt cacccaggac gacgacggct
    16501 acagcaccct gcaggccggc cgggaggacg gcggcggcag ccccctcgtc cgggaggcgg
    16561 cccgggcgtg tccggtcggc gccatcaccg tgtcggagcg ggtgggctga ccccggggcg
    16621 ttcggctccc ccggggcccg tcccttaggg ttccggggtg agcgaacagg ccgggaacag
    16681 tcgacgggcc gcgagcggcg gaccggtgcc ggacggcgga ccggcgggga accgcgaacc
    16741 ggcgcgaacc ggcgcacggg tgggggacgg tgagccgggc ggaagcaagg gcgccccctt
    16801 cctctacgtc gtcgtctgcg cggccggcgt ggcgtccggc gtcggtgcac tgatcgacgc
    16861 cgccctgcga cgcgactggg aggtgggcgt cttcgcgacc ccggtcgcca tggacggctt
    16921 cttcgacacc gccgacgtcg aggcccgcac cgggcgcccc atccgctcgg cgtggcgacg
    16981 ccccggcgag ccgcgcccct tcccggcccc ggacgccgtc gtggtcgccc ccgccacctt
    17041 caacaccgtc aacaagtggg ccgcgggcct ggccgacacc ctcgccgtgg ccaccctgtg
    17101 cgaggcctgc ggcctcggcg ttcccgtcgg tgtcctgccg tgcgtctccg acgcgctggc
    17161 ctcgcacccc gcctaccggg cgagcctgga ccggctgcgc gggatgggcg tgcgcttcgg
    17221 cgacccgtac gagggcgggg cggcggcggg cggcgaccgg cggttccact gggagcgcgc
    17281 cctggacctg ctcgaacggc gctgaccggg gtggcgttgg agtgcgcgcg aagtcgtacg
    17341 ctcgccctgt accgatgatc ccgagaacac aggagcagca acgatgcagt acgtgaagct
    17401 cggttcgacg ggcctcgacg tgtcgcggat ctgcctgggc tgcatgacct acggcgtccc
    17461 cggccgcggc gcccacgagt ggaccctcga cgaggacgcc gcgcgtccgc tgatccggca
    17521 ggcgctggag gccggggtca ccttcttcga cacggccaac gtctactccg acggcaccag
    17581 cgaggagatc gtcggcaagg cgctgcggga cttcgcccgc cgcgacgaca tcgtgctggc
    17641 gaccaaggtg cacggccgga tgcggcccgg gcccaacgga gccgggctgt cccgcaaggc
    17701 gatcatgacc gagatcgacc acagcctccg gcggctgggc accgaccacg tggacctgta
    17761 ccagatccac cgctacgacc cgcacacgcc catcgaggag acgatggagg ccctgcacga
    17821 cctggtgaag gcgggcaagg tccgttacct cggggccagt tcgatgtacg cgtggcagtt
    17881 ctccaaggcc cagtacacgg ccgagcggca cggctggacg aagttcgtgt ccatgcagaa
    17941 ccactacaac ctcgtgtacc gcgaggagga gcgcgagatg ctgcccctgt gcgcggacca
    18001 gggcgtggga gtactgccct ggagcccgct cgcccgcggc cggctcaccc gcgactggga
    18061 caccgccacc gggcgcagcg ccacggacgc gttcggcagc accctctacc cggagggcga
    18121 ccgcgccgtg gtcgaggcgg tgacccgcat cgccggcgag cgcggcgtgc cgcgcgccca
    18181 ggtggccctc gcctggctgc tgcaccagga cacggtgacc gccccgatcg tcggcgcgtc
    18241 gaagccgggg cacatcgagg acgcggtggc cgcggtcgaa ctggtcctcg gcgagaagga
    18301 gatcgaggag ctggagagcc cctacacgcc gcacccggtc gccggtcact gacggttggg
    18361 ccgtgcgagg cggacaccct gccggtgccg gtgggtcagg ggccggaccc cgcctccagg
    18421 gcggtgacgg acaccgacga cgcgttgccg cccaccggga ccgcaccggc cgtccactcc
    18481 accttgaggg aggcccgctc gtccggcggc gtgaccagca gcgcggccgg ggtcgcggtg
    18541 cgggcgccgc tgatctcggg gctggagaac gacagcccgg cccacgcgct cgcgccgggc
    18601 gtcagcgtga ggggctcggg cgagccgggc gcgcgctccg ggtccgggcc gagctgcttg
    18661 ccggacgcgt ccacgaaggc ggcgcccgga tagccgtaca ccgtgcaggt gcgctcggag
    18721 gtgttggtca ggacgagcgg gaagttccgc tgtccggcgc ccgggtcgag ccggccgacg
    18781 gcggcccgca actcggaggt gtggcagcgt ccgtcggtgc gggcggaggc cgacgcggac
    18841 ccggcggtgt cgctgggcgt gccggccgcc gccgcggtgc cggggtcggt ggccgtgccg
    18901 gtgcccgcgc tcggggccgc gtcggaggcg cgggcggagt gcgagggcgg gggcgtgccg
    18961 gacgtgccgt tctcgctgcc gcaggcgctc agcaggccga ggaccgcgag tccgcccgcg
    19021 agcagggccg tccggcgcac cggctgggac gtgttggcca tggcttcctc acactcccgt
    19081 ggttcccgcg cacgcctgcc gtggcgccgt gcgccctgta ctccgggtgt cccgtcgcac
    19141 ggcccgggaa acggcgacgg ctcactcctc ctcgaccagg cccagctcgg cccagatcgt
    19201 cttgccctcc gtcgtgtgcc tgctgcccca gcgctgggtg agctgggcca ccagcagcag
    19261 accgcgcccg ccctcgtccc aggtgcgggc ccggcgcagg tggggcgcgg tgtgactgct
    19321 gtcggagacc tcgcagatca gcgtggtcgc gtcgtggatg agccgcagcc ggatgggcgg
    19381 ggagccgtac cggatcgcgt tggtgaccag ctcgctcacc accagctcga cggtgaagga
    19441 ggcatctgcc agaccccaga cggcgagctg gtcgagcacc tgcttgcgca ccggggcgac
    19501 cagcgacggg tcggccggga tgtcccaggt ggccacctgc ccggtgggca gtccccgggt
    19561 gcgggccagc agcagggcca cgtcgtcgcc ggcgctgccc gccgggagca ggctgtgcag
    19621 cacccggtcg caggcggcgt ccagcgagtc gccgggcgcg gccagcgcct cgcgcagcag
    19681 tgccaggccg gcgtcggggt cccggtcccg gctctcgacc agtccgtcgg tgtagagcgc
    19741 caggacgctg ccctcgcgca gctccagctc ggccgactcg aagggcagcc cgcccacgcc
    19801 cagcggtggc cccgagggca gctcgacctg ccgcgccggg ccgtccggcg gcaccaggaa
    19861 gggcgccggg tgcccggccc tggccatggc gcagcgccgc gagaccgggt cgtacaccgc
    19921 gtacaggcag gtggcgccga cctcgccggc ccggtcgtcg ccggactcct cggagaggcg
    19981 gacgaccagg tcgtcgaggt gggtgagcag ttcctcgggc gtaaggtcga tgtcggcgag
    20041 ggtgcgtacg gcggtgcgca gccgccccat ggtggctgac gccgcgatgc cgtgtccgac
    20101 gacgtccccg acgaccatgg cgacccgcat cccggacagc gggatgacgt cgaaccagtc
    20161 gccgccgacg cccgagcggg ccgccggaag gtagcgggag gccgcctgca ccgctgcggt
    20221 gggcggcagc caccggggca gcaggctgcg ttgcagggtc agggtggcct cgcgctcgcg
    20281 cgagtagcgg cgggcgttgt cgatgcagac ggcggcgcgg gcgctgacct cctcggccag
    20341 caggacgtcg tcgtgggtga acgggtgcag gcgccggaac cggatgaaga ccgccacgcc
    20401 gagggtggtg ccgcgggcct ggagcggcac cgacatcacg gagtggacgc cgtgctcccg
    20461 cacctgccgc aggcgcgccg ggtcccagcc catccagcgc tccaggtcgc cgtgcgcctc
    20521 ggcggccacg atcgcccggc cggagaggag gcactcggcc tggggcgagc cggccgggta
    20581 gaagtccagc cgaccggtct cggcggccgc aggcggacac gtcgacgagt gggccgagcc
    20641 ggccgagtgg tcgggcaggt gcgtccggtg ggccgtccgg cgcaggccga ccggcggttc
    20701 gaccacggtg gcgggctcac cgccggtgtc ccgcgggtcc agcaggtcga cgctcacgaa
    20761 gtcggcgagt gcgggcacgc acacgtccgc cagttcctcg gcggtgcggt tgacgtcgag
    20821 ggtgctgccg acccgcacgc tggcctcgtt gaccagttgc agccgttccc gggccaggtg
    20881 ctgctcggtg aagtcgtggg cgctcacgca cacgccgcgc accagcccgt cggcgtcggt
    20941 gagcggcgcc atcagggcga cccaggcgtg ggcgcgctcc tcgccctcgg ccttcagatg
    21001 actgcgcagg tcctgccgcc ggccggtgg
//
