LOCUS       NZ_CP036534            12991 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. VN1 chromosome, complete genome.
ACCESSION   NZ_CP036534
VERSION     NZ_CP036534.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. VN1
  ORGANISM  Streptomyces sp. VN1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8341703)
  AUTHORS   Nguyen,H.T., Pokhrel,A.R., Nguyen,C.T., Pham,V.T.T., Dhakal,D.,
            Lim,H.N., Jung,H.J., Kim,T.S., Yamaguchi,T. and Sohng,J.K.
  TITLE     Streptomyces sp. VN1, a producer of diverse metabolites including
            non-natural furan-type anticancer compound
  JOURNAL   Sci Rep 10 (1), 1756 (2020)
   PUBMED   32019976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8341703)
  AUTHORS   Pokhrel,A.R., Nguyen,H.T., Dhakal,D., Nguyen,C.T., Pham,V.T.T. and
            Sohng,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2019) Department of BT-Convergent Pharmaceutical
            Engineering, Institute of Biomolecule Reconstruction, Sunmoon-Ro221,
            Asan, Chungnam 333-708, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: HGAP3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011650445.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 03:53:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,284
            CDSs (total)                      :: 7,197
            Genes (coding)                    :: 7,083
            CDSs (with protein)               :: 7,083
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 44 of 114
            Pseudo Genes (incomplete)         :: 82 of 114
            Pseudo Genes (internal stop)      :: 3 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:32:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7072031
            Orig. end                         :: 7085022
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036534.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jae Kyung Sohng.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..12991
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="28"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12991
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12991
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7991](+)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7991
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     misc_feature    complement(791..805)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.86"
                     /tool="antismash"
     misc_feature    complement(1102..1118)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.23"
                     /tool="antismash"
     gene            1169..2038
                     /locus_tag="EZV63_RS31220"
                     /old_locus_tag="EZV63_31680"
     CDS             1169..2038
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330308.1"
                     /locus_tag="EZV63_RS31220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31680"
                     /product="metallophosphoesterase"
                     /protein_id="WP_037772276.1"
                     /transl_table=11
                     /translation="MTSAAGAPGTLWAISDLHIGYPENRALVEKTYPDSPEDWLLVAGD
                     VAETVEDVRWALGILAERFRRVVWAPGNHELWTHPKDTVTLRGVARYEHLVEVCRELGV
                     TTPEDPYPVWEGAGGPAVVAPLFLLYDYSFLPAGCATKDEGLKYAHGTGVVCSDEYLLH
                     PDPYPSREAWCRARVAETERRLAELPAGLPRILVNHYPLDRHPTDVLWYPEFAMWCGTR
                     LTADWHRRFRVDTMVYGHLHIPRTTWHEGVRFEEVSVGYPREWRKRPDPPGRLRRILPS
                     PAREEAAR"
     gene            2035..2718
                     /locus_tag="EZV63_RS31225"
                     /old_locus_tag="EZV63_31685"
     CDS             2035..2718
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-167). E-value: 2.3e-22. Score:
                     71.3. Matches aSDomain:
                     nrpspksdomains_EZV63_RS31225_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031096.1"
                     /locus_tag="EZV63_RS31225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31685"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_037772277.1"
                     /transl_table=11
                     /translation="MIEELLPTTVVSVAAYGHDETGHLPLYPEEEAIVARAVAKRRREF
                     TAVRSCARRAMEKLGVPAQPVLPGERGAPSWPDGLVGSMTHCDGYCAAALARATDLASL
                     GIDAEPDGPLPEGVLDSVALPAEAERLRRLAEERPGVHWDRLLFSAKESVYKAWFPLTR
                     RWLDFLEADIEISVSPGGGPGSGTLRAALLVPGPTVGGRRLTHFDGRWTARGGLVTTAI
                     TVPHT"
     aSDomain        2344..2535
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS31225_ACPS.1"
                     /evalue="2.30E-22"
                     /label="EZV63_RS31225_ACPS.1"
                     /locus_tag="EZV63_RS31225"
                     /protein_end="167"
                     /protein_start="103"
                     /score="71.3"
                     /tool="antismash"
                     /translation="LGIDAEPDGPLPEGVLDSVALPAEAERLRRLAEERPGVHWDRLLF
                     SAKESVYKAWFPLTRRWLD"
     gene            complement(2829..3065)
                     /locus_tag="EZV63_RS31230"
                     /old_locus_tag="EZV63_31690"
     CDS             complement(2829..3065)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431523.1"
                     /locus_tag="EZV63_RS31230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31690"
                     /product="hypothetical protein"
                     /protein_id="WP_031044774.1"
                     /transl_table=11
                     /translation="MTTAVPTDHERTAVQAYLRLLHTVRAGLDTTAGAAGPPRPPVVPP
                     AVLDEAERALAAAGLAGNEEAFFRLLRGWCPGP"
     gene            complement(3213..3845)
                     /locus_tag="EZV63_RS31235"
                     /old_locus_tag="EZV63_31695"
     CDS             complement(3213..3845)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996371.1"
                     /locus_tag="EZV63_RS31235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31695"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_037772356.1"
                     /transl_table=11
                     /translation="MLPPAALAAVVARVAALADRLGVPHSDVFDVGCLSSASGVPESVV
                     GALLGGRPAGEPDVQARFVQRLDLLRRTRLKPNGRKYTQQEIADGAGMSRQQAGALING
                     DRRPTMEHCDAIQRFFRVHAGFLTAEDTEALAGTLRHTEQELLQQLADRERKASAAADG
                     DDPLERLLQDHGVRGIAWRAAQLPTDQHRDKVAEWLDMLLENVKRPE"
     misc_feature    4006..4021
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.07"
                     /tool="antismash"
     misc_feature    complement(4006..4023)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.4"
                     /tool="antismash"
     gene            4210..4863
                     /locus_tag="EZV63_RS31240"
                     /old_locus_tag="EZV63_31700"
     CDS             4210..4863
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069850.1"
                     /locus_tag="EZV63_RS31240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31700"
                     /product="hypothetical protein"
                     /protein_id="WP_031044770.1"
                     /transl_table=11
                     /translation="MAFQAEGQRPAPRPTSPDAQAYLRDYGTLLEAVPFPSLVVDHRWD
                     VVLANSAFRTLFRAAGPHPTAMPDDNFLRFVLFHPDASDVLGEHESSWCLPMLAHFAAT
                     LERHGHDPGLQAVRRDIAQDPLMEAAYRQGLPHWVRAVGARAVEHDGAVRPLHHPDPRR
                     GTTECRVVVETPPALGELGYTRLTLVLREPRRAPHRPPRARRSPSHLRVVPAAE"
     misc_feature    complement(4985..4995)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            5001..6152
                     /locus_tag="EZV63_RS31245"
                     /old_locus_tag="EZV63_31705"
     CDS             5001..6152
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007495640.1"
                     /locus_tag="EZV63_RS31245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31705"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_166625410.1"
                     /sec_met_domain="DAO (E-value: 4.1e-62, bitscore: 209.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESLTCDVVVVGVGMVGAACALYAAREGLDVIVVDRGQVAGGTT
                     GAGEGNLLVSDKEPGPELELALLSAGLWTGLAEGLGRETEYEPKGGVVVAETPEALAGL
                     ETFAAGQRAAGVSALGVTADRLHDLEPRLAPGLAGAVHYPQDAQVMPALAAAHLLRASG
                     ARLRTGRTVTGVLRGPGGAVRGVRTDRGDVHAPAVVNAAGPWGGEVAALAGVHLPVLPR
                     RGYVLVTEPLPPRIRHKVYAADYVADVASDSAALQTSPVVEGTAAGPVLIGASRERVGF
                     DRSVSLPALRALAAGATRLFPFLARVRALRTYAGFRPYLPDHLPAIGADPRAPGLFHAC
                     GHEGAGIGLSTGTGHLIAGLLTGAAPALDLTPFRPDRFCPEAR"
     gene            6149..6448
                     /locus_tag="EZV63_RS31250"
                     /old_locus_tag="EZV63_31710"
     CDS             6149..6448
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042989.1"
                     /locus_tag="EZV63_RS31250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31710"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_166625411.1"
                     /sec_met_domain="Fer2_4 (E-value: 2.1e-28, bitscore: 96.9,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLRLVRARPARAFTVTIDGRTVEALPGRTVAAALWAAGITSWR
                     TTRGTGRPRGVFCGIGVCFDCLVTVNDSPNQRACLVPARPGDVIRTQEGTGHED"
     gene            6438..7991
                     /locus_tag="EZV63_RS31255"
                     /old_locus_tag="EZV63_31715"
     CDS             6438..7991
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656536.1"
                     /locus_tag="EZV63_RS31255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31715"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_166625412.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.8e-26, bitscore:
                     91.8, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 3.2e-10, bitscore:
                     39.0, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTELVVVGAGPAGLAAALAADARGVRVTVVDAADGPGGQFYRQP
                     AAELNARRPQALHHQWRTWERLRDGLAASGVRLLTGHHVWTVTGGPDSFTVHALLGPGQ
                     DEPATVHADAVLLATGSHEHVLPFPGWTLPGVVTAGGAQAMLKGGLVVPGRVAVVAGTG
                     PLLLPVATGLAAAGTRVSALVESAGPRQVARYARALAGKLPEGAGHAARLLRHRVRPLA
                     RHTVVRAHGDDRLTGVTVAALDADGHVRRGTGRHLPCDTLAVGHGLLPQTDLAEGLGCH
                     LDGATVTVDAEQRTSAPGVWAAGEATGVGGAALALAEGHIAGRSAAARLRGTEPDPAGW
                     APAARTREALRTAAAALDAAFAPPAHWAAQVTDDTVVCRCEEVTAGAVREAADGLGAGD
                     VRTVKLLTRAGMGWCQGRMCATAVAGLTGCHSDPPRRPLARPVPLGILAGTAPDRAAPD
                     RTAPDRAAPDRAVSGRPVSASDRSPSEQASTGGLSSDRPPHGRLSRDQNPPEAFEEGSP
                     "
     gene            7988..8878
                     /locus_tag="EZV63_RS31260"
                     /old_locus_tag="EZV63_31720"
     CDS             7988..8878
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525029.1"
                     /locus_tag="EZV63_RS31260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31720"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_031044760.1"
                     /transl_table=11
                     /translation="MTDSRPWRGVLVATALPLNDDLSVDYDAYAEHCAWLVANGCDGVV
                     PNGSLGEYQVLTPEERTRVVETAVAAIGGGRVMPGVAAYGSAEARRWAEQAGGAGCGAV
                     MLLPPNAYRADERSVLAHYAEVARAGLPVVAYNNPIDTKVDLVPELLAQLHGEGHIQGV
                     KEFSGDVRRAYRIAELAPELDLLIGADDVALELALAGAKGWVAGYPNALPAACVELYRA
                     AVAGDLATAEPLYRQLHPLLRWDSKVEFVQAIKLSMDLAGRHGGACRPPRVPLLPAQEA
                     AVRAATEKALAAGLA"
     gene            8891..9892
                     /locus_tag="EZV63_RS31265"
                     /old_locus_tag="EZV63_31725"
     CDS             8891..9892
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358096.1"
                     /locus_tag="EZV63_RS31265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31725"
                     /product="proline racemase family protein"
                     /protein_id="WP_166625413.1"
                     /transl_table=11
                     /translation="MRSKLVLHSVDSHTEGMPTRVITGGIGTIPGATMNERRLYFREHR
                     DDVKQLLMNEPRGHAAMSGAILQPPTRPDCDWGVVYIEVSGYLPMCGHGTIGVATVLVE
                     TGMVEVTEPVTTIRLDTPAGVVVAEVAVEEGAAKAVTLRNVPSFAVGIDRAVTLPDGRT
                     VTYDLAYGGNFYAVLPLERLGLPFERSRKDDILAAGLSLMAAINAEGGPVHPEDPTIHG
                     CHHVQVTAPDATARHSRHAMVIHPGWFDRSPCGTGTSARMAQLHARGELPLHTEFVNES
                     FIGTRFGGRLLGTTEVAGHPAVLPSITGRAWITGTAQYLLDPADPFPAGFVL"
     gene            9889..10602
                     /locus_tag="EZV63_RS31270"
                     /old_locus_tag="EZV63_31730"
     CDS             9889..10602
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009323355.1"
                     /locus_tag="EZV63_RS31270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31730"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_166625414.1"
                     /transl_table=11
                     /translation="MTATGPVPPLPPALPVLGSRKPSHRERVAEALRAALIAGELRPGE
                     VYSAPGLAARFGVSATPVREAMLDLAKEGLVDTVPNKGFRVTAVSERQLDEYTHIRSLI
                     EIPTTVALAAGADAVALRALRPVAEEIVTSAAAGDLIAYVDADLRFHLGLLALAGNAHL
                     VEVVRDLRRRSRLFGLTALVEQGRLHASAEEHLEILDALLARDEDAVRAVMTRHLGHVR
                     GLWAAGAGAGAEPGA"
     gene            complement(10696..11679)
                     /locus_tag="EZV63_RS31275"
                     /old_locus_tag="EZV63_31735"
     CDS             complement(10696..11679)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511096.1"
                     /locus_tag="EZV63_RS31275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31735"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_037772361.1"
                     /transl_table=11
                     /translation="MATTTSRLLNLLSLLQTRRDWPGAVLAERLEISHRTVRRDIDRLR
                     EMGYRIRTTMGPDGGYRLDAGTELPPLLFDDEQVVALTVALQAATMTGAGIEEAALRAL
                     TAVRQVLPPRLRHQVGRLSFEAVPRPGDGPAASLSPRLLLTLSHAVRAREVLRFDYAAH
                     RPADREPGPPRRAEPHHLVTSHGRWYLVAWDLDHDDWRLFRADRMSPRTPTGPRFVPRE
                     VPGGSARDFVSARFKGSERGDAWPCVGTVVLRRPAAEVLPFAGDGTVEDLGPHRCRYTA
                     GSWSWIALAASLNRFDTDITVVGPPELTEAFARLAARNTATATGPS"
     misc_feature    11746..11761
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            11782..12246
                     /locus_tag="EZV63_RS31280"
                     /old_locus_tag="EZV63_31740"
     CDS             11782..12246
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016908703.1"
                     /locus_tag="EZV63_RS31280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_31740"
                     /product="VOC family protein"
                     /protein_id="WP_166625415.1"
                     /transl_table=11
                     /translation="MSITTTPHLNFHGQARAALEFYGIVFGGEATVTTYGDLGMPKDVP
                     GADGVVFGQVETAEGFRVMAYDIPGGTEEPAGAVGSTRRENGTTITTQPFFVSVRGESF
                     DEVEAYWKKLSDGASVVEPLAASAWSAGFGMLTDRFGVTWSLDVASAPAA"
     misc_feature    complement(12762..12777)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.51"
                     /tool="antismash"
ORIGIN
        1 agcacgggcc ggtcgccgaa catccggaac tgcacgttgg acaggtggtg caggccgaac
       61 gcctcggcga tccgccgggc cggcgccagc cactgctcgt ggagcgtgaa cccccggcgg
      121 cgtccgtgct tggtacggcc cacggcgagc cgcacccggt tgtccggccc ggtgaggcag
      181 tcgaccgaca cctccggctg ttcgagccgc ggcatcacca gccagtcgac gggctcctcg
      241 gccgcccgca gcgcttcgag gaccaggggc agcggcaccg agggactcgg gaaaccgttc
      301 aggtgcgtga gggagaaggg gtcccgggtg accatccgga agcccacccc gcccgccccg
      361 gacgcgggct tgaagcacgc ccgaaggcct cgctcctcca gctcctccac cgcacggacc
      421 agctcgtcgg ccgtgcgcac ccgccaccac ggcggcaccg gcacgccgat cgcccggacc
      481 gcctcgtagg cgatcacctt gtcgtggaag acggccacgg cctccggcgg cggcgcgagc
      541 agtgccgtgc ccgccgcctc gaaatcggcc cggtgggcca cgatcgccga ctggtgcagc
      601 cgcggcacga agacgtcgat cccgcgccgc gcgcactggg ccagggcgta ctcgacgtag
      661 cccgccgggg agagcccctc gggctccagg tcggcggtgt cggcggcggc cagtacgggg
      721 gagtccggat caccgtgcgt cgcatggatc tcgacggccc ggtcggcggg atttctccgc
      781 agctgatcca tgaagaagac gttctccgcg tacgtacggt tgagccagac gcgtacggga
      841 gaaaccatgc aagccgcctt tcagggtccg cgcgggcagg gcgaagcagg ccgtgcccgg
      901 ccagggggtt ggagggtcac cgagccgcgg cgcgcgagga aggaggcgtg gcggtggtgt
      961 tggggcgatc ataggggtac gtgcgccccc gagcgcaacg agcgtcacac ggatgcaccg
     1021 cgcccgtgcg gggccttccg gcgcggcgcg ggtcctgccc tggtccggcg ggtccaggac
     1081 gctcttgtga ccgggtcggg gatgtgatct cgtggcacgg gagggacgtc gcgcagacgt
     1141 cggaggcatg tcgggaaggg gtggggggat gacgtcggcg gccggtgccc cgggcacgct
     1201 ctgggccatc agcgatctgc acatcggata cccggagaac cgtgcgctgg tcgaaaagac
     1261 gtacccggac tctccggagg actggcttct ggtggccggc gacgtggccg agaccgtcga
     1321 ggacgtccgc tgggcgctcg gcatcctcgc ggagcgcttc cgccgcgtcg tctgggcccc
     1381 cggcaaccac gagctgtgga cgcaccccaa ggacacggtc accctgcggg gagtcgcccg
     1441 ctacgagcac ctggtcgagg tctgccgaga gctgggcgtg acgacgcccg aggatcctta
     1501 cccggtctgg gagggcgcgg gcggcccggc ggtcgtcgcc ccgctgttcc tgctctacga
     1561 ctactcgttc ctgcccgccg gatgcgcgac caaggacgag gggctgaagt acgcccacgg
     1621 caccggcgtc gtgtgcagcg acgagtacct gctccacccc gacccgtacc ccagccgcga
     1681 ggcgtggtgc cgggcgcggg tcgccgagac cgaacgcagg ctggccgaac tcccggccgg
     1741 gctgccgcgg atcctggtga accactaccc gctggaccgg caccccaccg acgtcctgtg
     1801 gtaccccgag ttcgccatgt ggtgcggcac ccggctgacc gccgactggc accgcaggtt
     1861 ccgggtcgac acgatggtct acggccatct gcacatcccg cgcaccacct ggcacgaagg
     1921 cgtccgcttc gaggaggtct cggtgggcta cccccgggaa tggcgcaagc ggcccgaccc
     1981 gcccggacgg ctgcgccgca tcctgccgtc gcccgcccgc gaggaggccg cccggtgatc
     2041 gaggaactgc tgcccaccac ggtcgtcagc gtggccgcgt acggccacga cgagaccggg
     2101 cacctgccgc tgtacccgga ggaggaggcg atcgtcgcgc gggcggtcgc caagcggcgc
     2161 cgggagttca ccgccgtacg gtcctgcgcc cgccgggcca tggagaagct cggcgtgccc
     2221 gcgcaacccg tcctgcccgg cgaacgcggg gcgccgagct ggccggacgg cctggtgggc
     2281 agcatgaccc actgcgacgg gtactgtgcc gcggccctgg cccgcgccac cgacctggcc
     2341 tccctcggca tcgacgccga acccgacggt ccgcttccgg agggggttct ggacagtgtg
     2401 gccctgcccg ccgaggcgga gcggctgcgc cggctggccg aggagcggcc cggcgtgcac
     2461 tgggaccggc tgctgttcag tgccaaggag tcggtctaca aggcctggtt ccccctgacc
     2521 cggcggtggc tggacttcct ggaggcggac atcgagatct ccgtgagccc gggcggcggc
     2581 cccggcagcg gaaccctgcg cgccgcgctc ctggtgccgg ggccgaccgt gggcggccgc
     2641 cgcctgaccc acttcgacgg ccggtggacg gcgcgcggcg gcctggtcac cacggcgatc
     2701 acggtcccgc acacctgacc gcccccctgc ctcctgcccc ctgtcccctg cccgacgggc
     2761 cccggccgac cggctgttgg gccgttaggc cgttaagccg ttgggtgggc gcgccgccgc
     2821 ggtccgtgtc acgggccggg gcaccagccg cgcagcagcc ggaagaacgc ctcctcgttc
     2881 cccgccagtc ccgcggccgc cagggcccgt tcggcctcgt ccagtacggc cggcgggacg
     2941 acgggcgggc gagggggacc ggccgcaccc gccgtggtgt cgagaccggc ccgcacggtg
     3001 tgcagaagcc gcaggtaggc ctggacggcg gtgcgctcgt ggtcggtcgg tacggcggtg
     3061 gtcatcggtc ggctctcccc acaacgacgt cagcggtcac gcaccgcacg gcggcggcac
     3121 cctcccagct tgccgcccgc cactgacaat cccccgagcc gcgctccccg cgcggaccgg
     3181 ccgggccccg tccaacgccc cctgcggctc cgctactcgg ggcgtttgac gttttccagg
     3241 agcatgtcca gccactcggc gaccttgtcg cggtgctggt cggtgggcag ttgggcggcc
     3301 cgccaggcga tgccgcgcac gccgtggtcc tgcagcagcc gctccagcgg gtcgtcgccg
     3361 tcggcggccg ccgacgcctt ccgctcccgg tcggccagtt gctggagcag ttcttgttcg
     3421 gtgtgccgca gggtgccggc gagcgcctcg gtgtcctcgg cggtcaggaa gccggcgtgg
     3481 acgcggaaga agcgctggat ggcgtcgcag tgctccatgg tgggccgccg gtcgccgttg
     3541 atcagcgcgc ccgcctgctg ccgcgacatg ccggcgccgt cggctatctc ctgctgggtg
     3601 tacttgcggc cgttcggctt cagccgggtg cggcgcagca ggtccaaccg ctggacgaac
     3661 cgggcctgca catcgggctc gcccgccggc cggccgccga gcagcgcgcc gacgacggac
     3721 tcggggacgc cggaggcgct ggacaggcac ccgacgtcga agacgtcgga gtgcggcacg
     3781 ccgagccggt cggcgagcgc ggcgacccgg gcgacgacgg cggcgagcgc ggccggaggc
     3841 aggatacccg gcgtctcggg gccacgtcct tccgaaccgc gctgtacgaa cgggtcggcc
     3901 tcggagccac taccctcaac accacgaccc acggcgtcgc aacccgccga gtcacgcccc
     3961 tcgaagccac ccgtcaccga aagctctccc acgtctctca caggcctcac aggcttctca
     4021 caagcgattg ccgtgaactt cccggagagt agcctgccgc tcgaacccac atccaggtct
     4081 cgccacaact gtggcctatt ccagccgtca acaggcacga aatgccacga tagttgacac
     4141 gcctcgcgtc ggggcaccag gatcgggacg ccgcgagaag gccgcatagg caagaggggt
     4201 gacctcccga tggcatttca ggcagaaggg cagcggccgg cgccgcggcc cacgtccccc
     4261 gacgcccagg cgtatctccg ggactacggc acgcttctgg aggccgtccc cttcccctcg
     4321 ctcgtcgtcg accaccgctg ggacgtggtg ctggccaaca gcgccttccg gacgctcttc
     4381 cgggcggccg gcccccaccc gacggccatg ccggacgaca acttcctccg gttcgtgctc
     4441 ttccacccgg acgcgtcgga cgtcctcggc gagcacgagt cgagctggtg cctccccatg
     4501 ctggcgcact tcgccgccac cctggagcgg cacggccacg accccggcct gcaggcggtc
     4561 cgccgcgaca tcgcccagga ccccctgatg gaggccgcct accggcaggg cctgccgcac
     4621 tgggtccgcg ccgtcggcgc ccgggccgtc gaacacgacg gcgccgtacg cccgctgcac
     4681 caccccgacc cgcgccgggg gaccaccgag tgccgggtcg tggtcgagac gcccccggcg
     4741 ctgggggagt tgggctacac ccggctgacc ctggtcctcc gcgagccgcg ccgcgccccg
     4801 caccgtccgc cgcgcgcccg ccgttccccg tcccacctga gagtcgtccc cgcggccgag
     4861 tgaccgtcag cggccgaggg accgccgtcg gccgagtggc cgtcagcggc cgagtgaccg
     4921 ccgtcgggtg gccgctgcac ggcttgtcgt cgcgcccccg ccctcttctc agcagctgtg
     4981 gtgtgtgaca tagtactggc gtgagcgagt ccctgacctg cgatgttgtc gtggtcgggg
     5041 tcggcatggt aggcgcggcc tgtgcgctgt acgccgcccg tgagggcctc gacgtgatcg
     5101 tggtggaccg tggccaggtg gccggcggca ccaccggagc cggcgagggc aacctcctgg
     5161 tctccgacaa ggagccggga cccgagctgg aactggccct gctctccgcc ggcctgtgga
     5221 ccgggctggc cgagggactg ggccgcgaga ccgagtacga gcccaagggc ggtgtcgtcg
     5281 tcgccgagac cccggaggcg ctggccggtc tcgagacctt cgccgccggc cagcgggcgg
     5341 ccggggtgtc ggcgctcggt gtcaccgcgg accggctgca cgacctggag ccccggctcg
     5401 ccccgggcct cgcgggcgcc gtgcactacc cccaggacgc ccaggtcatg cccgccctgg
     5461 ccgccgccca cctgctgcgc gcgtccggcg cccggctgcg caccggccgc acggtgaccg
     5521 gcgtgctgcg cggccccggc ggcgccgtgc gcggcgtgcg caccgaccgg ggcgacgtgc
     5581 acgcccccgc ggtcgtcaac gccgccgggc cctggggagg cgaggtggcc gccctggccg
     5641 gcgtacacct accggtactg ccccggcgcg gctacgtcct ggtcaccgaa ccgctgccgc
     5701 cccgcatccg gcacaaggtg tacgccgcgg actacgtcgc cgacgtcgcc agcgactcgg
     5761 ccgccctgca gacctccccg gtcgtggagg gcaccgccgc cggaccggtc ctcatcggcg
     5821 cgagccgcga gcgggtcggc ttcgaccgct ccgtgtcgct gcccgcgctg cgggcactgg
     5881 cggccggggc gacccggctg ttccccttcc tcgcccgcgt gcgcgccctg cgcacgtacg
     5941 ccggcttccg gccgtatctc cccgaccacc tgccggcgat cggcgccgac ccccgggccc
     6001 ccgggctctt ccacgcctgc gggcacgagg gcgcgggcat cggcctgtcc accggcaccg
     6061 ggcacctgat cgccgggctg ctgaccggag cggctccggc gctcgacctc accccgttcc
     6121 gtcccgaccg cttctgtccg gaggcccggt gaatcccctc aggctggtcc gggcgcggcc
     6181 cgcgcgcgcc ttcacggtca ccatcgacgg ccggacggtc gaagcactgc ctggccggac
     6241 ggtcgccgcc gcgctgtggg cggccggcat cacctcctgg cgcaccaccc gggggaccgg
     6301 ccgtccgcgg ggcgtgttct gcggcatcgg cgtctgcttc gactgcctgg tcaccgtcaa
     6361 cgactcaccg aaccagcggg cctgcctggt gccggcgcgg ccgggcgacg tgatccgcac
     6421 ccaggagggc accgggcatg aggactgaac tcgtggtcgt gggagccgga ccggccggtc
     6481 tcgcggcggc gctggcggcg gacgcgcgag gggtgcgggt cacggtcgtg gacgccgcgg
     6541 acgggcccgg cgggcagttc taccggcagc cggcggccga gctgaacgcc cggcggccgc
     6601 aggccctgca ccaccagtgg cgcacctggg agcggctgcg ggacgggctc gccgcgagcg
     6661 gtgtacgcct gctgaccggc catcacgtgt ggaccgtgac gggcgggccc gactccttca
     6721 ccgtgcacgc gctgctcggc cccgggcagg acgagcctgc caccgtgcac gccgacgccg
     6781 tgctgctcgc caccgggagc cacgaacacg tgctgccgtt ccccggctgg accctccccg
     6841 gcgtcgtcac cgccggcggc gcccaggcga tgctcaaggg cggtctggtg gtgcccgggc
     6901 gggtcgcggt cgtcgccggc accggccccc tgctgctccc cgtcgcgacc ggcctcgcgg
     6961 cggccggaac gcgggtgtcc gcgctcgtgg agtcggccgg cccgcgccag gtcgcccggt
     7021 acgcccgcgc actggccggc aagctccccg agggcgccgg acacgccgcc cggctcctgc
     7081 gccaccgcgt ccgccccctc gcccggcaca ccgtcgtccg cgcccacggc gacgaccgcc
     7141 tgaccggcgt caccgtcgcg gccctggacg ccgacgggca cgtcaggcgc ggcaccggac
     7201 gtcatctgcc ctgcgacacc ctggccgtcg gccacggcct gctcccgcag accgacctcg
     7261 ccgaagggct cggctgccac ctggacgggg cgacggtgac cgtcgacgcc gagcagcgca
     7321 cgagtgcccc cggcgtctgg gcggcggggg aggccaccgg cgtcggcggc gccgccctcg
     7381 ccctcgccga ggggcacatc gcggggcgtt cggccgccgc ccggctgcgc ggcaccgagc
     7441 cggaccccgc gggctgggca ccggccgccc gcacccgcga ggcgctgcgc acggccgccg
     7501 ccgcgctcga cgccgcgttc gccccaccgg cgcactgggc agcgcaggtc accgacgaca
     7561 ccgtcgtctg ccgctgcgag gaggtcaccg ccggtgccgt ccgcgaggca gccgacgggc
     7621 tcggcgcggg cgacgtccgc accgtgaagc tgctcacccg ggccgggatg ggctggtgcc
     7681 agggccggat gtgcgccacc gccgtcgccg gcctcaccgg ctgccactcc gacccgcccc
     7741 ggcgccccct cgcccgcccc gtccccctcg gcatcctcgc cgggacagca ccggaccggg
     7801 ccgctccgga ccggacagca ccggaccggg ccgctcccga ccgggccgtc tccgggcggc
     7861 ccgtgtccgc gtccgaccgg tccccgtccg aacaggcctc gaccggcgga ctctcgtccg
     7921 accggccccc gcacggacgg ctctcgcgcg accagaaccc tccggaagcc ttcgaggaag
     7981 gatccccatg accgactccc gcccctggcg cggcgtgctc gtcgccaccg cgctcccgct
     8041 caacgacgac ctctccgtcg actacgacgc ctacgccgag cactgcgcct ggctcgtcgc
     8101 gaacggctgc gacggcgtcg tgcccaacgg ctccctcggc gagtaccagg tcctcacccc
     8161 cgaggagcgc acccgtgtcg tcgagaccgc cgtcgcggcg atcggcggcg ggcgcgtgat
     8221 gcccggcgtc gccgcctacg gctcggccga ggcccgccgc tgggccgagc aggcgggcgg
     8281 ggcgggctgc ggcgcggtga tgctgctgcc gcccaacgcc taccgcgcgg acgagcgttc
     8341 ggtcctcgcc cactacgccg aggtcgcgag ggcgggcctg cccgtcgtcg cgtacaacaa
     8401 ccccatcgac accaaggtcg acctggtgcc cgagctgctc gcccaactgc acggcgaggg
     8461 ccacatccag ggcgtgaagg agttctccgg cgacgtccgc cgcgcctacc gcatcgccga
     8521 actcgccccc gaactggacc tgctgatcgg cgccgacgac gtcgcgctgg aactggcgct
     8581 ggcgggcgcg aagggctggg tcgccggata ccccaacgcg ctccccgccg cctgcgtcga
     8641 gctgtaccgg gcggccgtcg ccggggacct ggccaccgcc gagccgctgt accggcagct
     8701 gcacccgctg ctgcgctggg actcgaaggt cgagttcgtg caggccatca agttgtccat
     8761 ggacctcgcg ggacggcacg gcggggcctg caggccgccc cgcgtccccc tcctgcccgc
     8821 ccaggaggcg gccgtgcgcg ccgccaccga gaaggccctc gcggccggac tggcgtaggg
     8881 gagtaccgcc gtgcgcagca aactcgtcct gcactccgtc gactcgcaca ccgagggcat
     8941 gcccacccgg gtgatcaccg gcggcatcgg caccatcccc ggcgccacca tgaacgaacg
     9001 gcggctgtac ttccgcgagc accgcgacga cgtcaaacag ctgctgatga acgagccgcg
     9061 cggccacgcc gccatgagcg gcgccatcct ccagccgccc acccgccccg actgcgactg
     9121 gggcgtcgtc tacatcgagg tctccggcta cctccccatg tgcgggcacg gcacgatcgg
     9181 cgtggcgacc gtcctcgtgg agaccggcat ggtcgaggtg accgagccgg tcaccaccat
     9241 ccgcctggac acccccgccg gggtcgtcgt cgccgaggtg gcggtcgagg agggggccgc
     9301 caaggcagtg accctgcgca acgtgccctc cttcgccgtc ggcatcgacc gcgcggtcac
     9361 cctgcccgac ggccgcacgg tgacgtatga cctcgcctac ggcggcaact tctacgccgt
     9421 actgccgctg gagcggctcg ggctgccctt cgagcggtcc cgcaaggacg acatcctcgc
     9481 ggcgggtctg tccctgatgg cggcgatcaa cgccgagggc gggccggtcc accccgagga
     9541 cccgaccatc cacggctgtc accatgtaca ggtgaccgca cccgacgcca ccgcccggca
     9601 ctcccggcat gccatggtga tccaccccgg ctggttcgac cgctcgccgt gcggcaccgg
     9661 caccagtgcc cgcatggccc agctgcacgc ccggggcgaa ctgccgctgc acaccgagtt
     9721 cgtgaacgag tccttcatcg gcacgcggtt cggcggacgg ctgctcggca ccaccgaggt
     9781 cgccgggcac ccggccgtgc tgcccagcat caccggccgc gcctggatca ccggcaccgc
     9841 ccagtacctg ctggacccgg ccgacccgtt ccccgcgggg ttcgtgctgt gaccgcgacc
     9901 ggcccggtgc cgccgctgcc gcccgccctg cccgtcctgg gcagccgcaa gcccagccac
     9961 cgcgagcggg tcgccgaggc gctgcgggcc gccctgatcg cgggcgaact gcgccccggc
    10021 gaggtctact cggctcccgg cctggccgcc cgcttcggcg tgtccgccac cccggtccgc
    10081 gaggccatgc tcgacctcgc caaggagggg ctggtcgaca ccgtgcccaa caagggcttc
    10141 cgggtcaccg ccgtctccga gcgccagctg gacgagtaca cgcacatcag gtcgctcatc
    10201 gagatcccca ccaccgtggc actcgccgcc ggtgccgacg ccgtcgcgct ccgggccctg
    10261 cgcccggtcg ccgaggagat cgtcacctcg gcggcggccg gcgacctcat cgcgtacgtc
    10321 gacgccgatc tccgcttcca cctcgggctg ctggcgctcg cgggcaacgc ccacctggtg
    10381 gaggtcgtac gggacctgcg ccgccgctcc cgcctgttcg ggctgacggc gctggtcgag
    10441 caggggcggc tgcacgcgtc ggcggaggag cacctggaga tcctcgacgc gctgctcgcc
    10501 cgcgacgaag acgccgtgcg cgcggtgatg acgcggcacc tgggccacgt acgcgggctg
    10561 tgggcagccg gtgccggtgc cggtgcggag cccggagcct gaggggcgcg gccgacacga
    10621 tcggcgggcc gggggagggc ggcgggccgg cggagcgtcg gcacccggag agcgccgtgg
    10681 caggggccgt ctccgtcacg acgggccggt cgccgtcgcc gtgttgcggg ccgcgagccg
    10741 ggcgaacgcc tcggtgagct ccggcgggcc gacgaccgtg atgtcggtgt cgaagcggtt
    10801 gagggaggcg gccagcgcga tccaggacca cgatcccgcg gtgtagcggc accgatgggg
    10861 gccgagatcc tccacggtgc cgtcgccggc gaacggcaga acctcggcgg cggggcgccg
    10921 caggacgacg gtgcccacgc acggccatgc gtcgccccgc tcggacccct tgaagcgcgc
    10981 ggagacgaag tcccgggcgc tgccgccggg gacctcccgg gggacgaaac gggggccggt
    11041 cggggtgcgc ggggacatgc ggtcggcgcg gaagagccgc cagtcgtcgt ggtcgaggtc
    11101 ccaggccacc aggtaccagc ggccgtggga cgtcacgagg tggtgcggct cggcccggcg
    11161 cggcggcccg ggctcccggt cggcgggccg gtgggcggcg tagtcgaagc ggagcacctc
    11221 gcgggcgcgg acggcgtgcg agagggtgag cagcagccgc ggcgagaggg aggcggccgg
    11281 cccgtcgccg gggcggggga cggcctcgaa ggagagccgg ccgacctggt gccgcagccg
    11341 cggaggcagg acctggcgga cggcggtcag tgcccgcagg gccgcctcct cgatacccgc
    11401 tccggtcatg gtggcggcct gcagggccac ggtcagcgcg accacctgct cgtcgtcgaa
    11461 cagcagaggg ggcagttcgg tgccggcgtc gagccggtac ccgccgtcgg gccccatggt
    11521 cgtccggatg cggtagccca tctcccggag ccggtcgatg tcccgccgca ccgtgcgatg
    11581 gctgatctcc agccgttcgg ccaggacggc gcccggccag tcgcgcctgg tctgcagcag
    11641 cgacagcagg ttgagcagcc gggaggtggt cgtcgccatg cccacgagga taaatcgagt
    11701 ctgggacaag aactgtcctc tactgctgcc agagtcagtg gtgccggcac aagccggtca
    11761 ctgtgtgtac gaggagcagc tgtgagcatc acgacgaccc cccacctcaa cttccacggc
    11821 caggcccgtg ccgccctgga gttctacggc atcgtcttcg gcggggaggc caccgtcacc
    11881 acgtacggcg acctcggcat gccgaaggac gttccgggcg ccgacggggt ggtcttcggc
    11941 caggtcgaga ccgccgaggg cttccgcgtc atggcctacg acatccccgg tgggaccgag
    12001 gagccggccg gggccgtggg ctcgacgcgc cgggagaacg gcaccaccat caccacccag
    12061 ccgttcttcg tctcggtgcg cggcgagagc ttcgacgagg tcgaggcgta ctggaagaag
    12121 ctgtccgacg gcgcctcggt cgtcgagccc ctggccgcct cggcgtggag cgcgggcttc
    12181 ggcatgctca ccgaccgctt cggggtcacc tggagcctgg acgtggcctc cgcccccgcg
    12241 gcatgagccc gcggctgctc cgcggagcag ccgcccgccg ccgtggcgcc gtcccgtgac
    12301 cgcgccacgg cagccccccc caccggtgcg gccgggggcg cccggccgca ccgacagcat
    12361 ccgcagccgt accggaggag agaccatgcg ccacgtcccc gacagcgagc gacgggcgcg
    12421 tctggcggtc cggcacgcgc tcgccccggc gcaccgggta agcgggcccg aggacgccgc
    12481 tcgcgcggtg gtcgccctgc acgccaccga cgccccctcg gtgcacctcg cggtgtgggc
    12541 gcggaccagg gacaccacac ccggcgacgt cgaccgggca ctgtacgagg accggaccct
    12601 cgtcaagcag ctcgcgatgc gacgcacgct gttcactttc ccccgcgacc tgctgcccgc
    12661 cgccctgtcc agtgccgcgg cccgggtggc gacagccgaa cgcgcgcggc tgatacggga
    12721 cttcgagcgg gccggggccg cccccgatgc cgcggcctgg ctcgagcagg cacgcgagga
    12781 cgtcgaggcg gcgctcgcgc gaagcccctc ggccctgtcc acggcgcagc tgcgcaaggc
    12841 cgtcgcgcac atcgacaccg tcgtcccggg caggagcggc gaacagtggt ccgcacccca
    12901 gatcctcacc cttctcgggg cgcagggttc cctcgtgcgc ggtccctcca cgggacggtt
    12961 cccgaccgca cggcccctgt ggacgctgcc c
//
