LOCUS       NZ_CP036534            25191 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. VN1 chromosome, complete genome.
ACCESSION   NZ_CP036534
VERSION     NZ_CP036534.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. VN1
  ORGANISM  Streptomyces sp. VN1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8341703)
  AUTHORS   Nguyen,H.T., Pokhrel,A.R., Nguyen,C.T., Pham,V.T.T., Dhakal,D.,
            Lim,H.N., Jung,H.J., Kim,T.S., Yamaguchi,T. and Sohng,J.K.
  TITLE     Streptomyces sp. VN1, a producer of diverse metabolites including
            non-natural furan-type anticancer compound
  JOURNAL   Sci Rep 10 (1), 1756 (2020)
   PUBMED   32019976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8341703)
  AUTHORS   Pokhrel,A.R., Nguyen,H.T., Dhakal,D., Nguyen,C.T., Pham,V.T.T. and
            Sohng,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2019) Department of BT-Convergent Pharmaceutical
            Engineering, Institute of Biomolecule Reconstruction, Sunmoon-Ro221,
            Asan, Chungnam 333-708, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: HGAP3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011650445.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 03:53:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,284
            CDSs (total)                      :: 7,197
            Genes (coding)                    :: 7,083
            CDSs (with protein)               :: 7,083
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 44 of 114
            Pseudo Genes (incomplete)         :: 82 of 114
            Pseudo Genes (internal stop)      :: 3 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:32:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6774930
            Orig. end                         :: 6800121
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036534.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jae Kyung Sohng.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25191
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="26"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25191
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25191
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15191](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15191)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    31..46
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     misc_feature    complement(135..148)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            complement(611..1393)
                     /locus_tag="EZV63_RS29975"
                     /old_locus_tag="EZV63_30415"
     CDS             complement(611..1393)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (30-175). E-value: 2.5e-09.
                     Score: 29.2. Matches aSDomain:
                     nrpspksdomains_EZV63_RS29975_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669262.1"
                     /locus_tag="EZV63_RS29975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30415"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_346268471.1"
                     /transl_table=11
                     /translation="MAFAPPRTAVATALRCGDEKGPLLTMASRRVLITGASRGIGLAVA
                     ERLARQGHRPIGLARTSTDAFPGDFHEVDLSDRAATDTALRAVLAQGPVDAVVNNVGLV
                     RPASVHEVELDDLHAVYDMTVRVAVQAVQATLPAMTAHGWGRIVNITSLVTVGKPERTA
                     YGAAKAALDFCTRAWAGELATTGVTVNAVAPGPTETELFRANNPAGSASEQRYLAGTPS
                     GRLGRPDDIAAAVCFLLSQEAAHITGQILRVDGGASTG"
     aSDomain        complement(869..1303)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS29975_PKS_KR.1"
                     /evalue="2.50E-09"
                     /label="EZV63_RS29975_PKS_KR.1"
                     /locus_tag="EZV63_RS29975"
                     /protein_end="175"
                     /protein_start="30"
                     /score="29.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VLITGASRGIGLAVAERLARQGHRPIGLARTSTDAFPGDFHEVDL
                     SDRAATDTALRAVLAQGPVDAVVNNVGLVRPASVHEVELDDLHAVYDMTVRVAVQAVQA
                     TLPAMTAHGWGRIVNITSLVTVGKPERTAYGAAKAALDFCT"
     CDS_motif       complement(1232..1300)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS29975_0001"
                     /evalue="5.00E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="EZV63_RS29975"
                     /protein_end="54"
                     /protein_start="31"
                     /score="22.4"
                     /tool="antismash"
                     /translation="LITGASRGIGLAVAERLARQGHR"
     gene            complement(1441..2262)
                     /locus_tag="EZV63_RS29980"
                     /old_locus_tag="EZV63_30420"
     CDS             complement(1441..2262)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="EZV63_RS29980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30420"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_166625303.1"
                     /transl_table=11
                     /translation="MSEDVVAPSPTDAAGSLQVWLEALHTSSRRLTDTVASLSERELQQ
                     PSMASGWSIAQVLSHLGSAAEISTGLLERGIAGDERGPVREDLEPVWQRWNTLPPPAQR
                     EAWQEADTRHLQLLDSLGMSQQLWVRVPYFAGLLNLPDYAGYRLSEHSVHAWDVEAVLT
                     PGATIPAGEVELLWERLDLVATRFRDATTLARLAPAQLTIALTSPARTVLLDLGAELHL
                     YPCEPAEPVGSVTGAAEAVLRLVYGRHQPTDEVQVSGAVTLTDLTALFPGF"
     gene            complement(2262..3026)
                     /locus_tag="EZV63_RS29985"
                     /old_locus_tag="EZV63_30425"
     CDS             complement(2262..3026)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (18-237). E-value: 9.4e-34. Score:
                     108.7. Matches aSDomain:
                     nrpspksdomains_EZV63_RS29985_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008747396.1"
                     /locus_tag="EZV63_RS29985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30425"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_037760940.1"
                     /transl_table=11
                     /translation="MSQQNPSYFTAFKNLAMSRTEAGVLTLRFHTDDGPATFTGQTHTD
                     FPRALFEIGEDRDNRVLVLTGTGDRFMTDIDGASLGDITKPAQWDRTVAEGRRVLQRLV
                     DLEMPVIAAVNGPASVHSEYALLADIVIAADTTVFSDFPHLTFGIVPGDGIQIAWEEAL
                     GVNRARYLTLTQGSFTAEQAERWGAVAEVLPLAQVLPRAQQLAEGLAAKPQLLTRYLAV
                     TLRQRISRRMAEGLQLGMALEGLTAADLAYQQ"
     aSDomain        complement(2316..2972)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS29985_ECH.1"
                     /evalue="9.40E-34"
                     /label="EZV63_RS29985_ECH.1"
                     /locus_tag="EZV63_RS29985"
                     /protein_end="237"
                     /protein_start="18"
                     /score="108.7"
                     /tool="antismash"
                     /translation="RTEAGVLTLRFHTDDGPATFTGQTHTDFPRALFEIGEDRDNRVLV
                     LTGTGDRFMTDIDGASLGDITKPAQWDRTVAEGRRVLQRLVDLEMPVIAAVNGPASVHS
                     EYALLADIVIAADTTVFSDFPHLTFGIVPGDGIQIAWEEALGVNRARYLTLTQGSFTAE
                     QAERWGAVAEVLPLAQVLPRAQQLAEGLAAKPQLLTRYLAVTLRQRISRRMAEGLQ"
     gene            3284..4204
                     /locus_tag="EZV63_RS29990"
                     /old_locus_tag="EZV63_30430"
     CDS             3284..4204
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="EZV63_RS29990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30430"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_166625304.1"
                     /transl_table=11
                     /translation="MEIRAMRAFVTVVEEGGLSAAARRLHISQPALSQTMSALEREFGQ
                     QLLIRSSTGVQATDTGLLLLAESRAVLARYDQALAVMTARTGESATTLRIGIPLELPAD
                     LLSKALLELSAAHPDTRVQARHLSTSAQVTELHRGNLELGLLRERPQGQELDAMLVVKE
                     HLGVLLAAERAAELAGPGGIRLDALNALAWVGFPRSGSPAWYDELTAILRSHGIDPGPQ
                     VPDGQPLIAEVKLASVSAGRAFTLAPPGWSQPLPNSVTWFPLVGHPIVRRTWAVWNAGS
                     HRRDLGHLVAALDQPARKAVSDATP"
     misc_feature    3326..3335
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(4417..4539)
                     /locus_tag="EZV63_RS37440"
     CDS             complement(4417..4539)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EZV63_RS37440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_265107279.1"
                     /transl_table=11
                     /translation="MRNDRSEAALVAAHRAGAGKWLFAERRLMVDWTETRPSTP"
     gene            complement(4607..5617)
                     /locus_tag="EZV63_RS30000"
                     /old_locus_tag="EZV63_30440"
     CDS             complement(4607..5617)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010352629.1"
                     /locus_tag="EZV63_RS30000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30440"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_194963074.1"
                     /transl_table=11
                     /translation="MNTQDRIRLMLWNLERDGGPEPRPGVLPERWRQGYEEVLKPQRPD
                     WLAMLELKYSQTRPDVPPAEKHAAKRRFTAAQQILGMRGFRAAVGQRTNPTGVFIREAV
                     FPSARQRHHPVGHSAPPTHVELRIPEAPDVPIITASLHSAFCNPAQRRSEAMDLTELVD
                     KVKAHQTNPARGHAACWLFGDTNEYPVPVGEQVPAIDWSRVTDVVHRRHRAIKQPDCTW
                     VSCTAVDEIMHDCGMHDPARWAAHRLGQTTALAATAGHAAAGQGGPRRIDRGYLDAWSV
                     QAVEDVRVLDTTGLSDHHAVIVDLSRRKLIEGLHRRTSAIASWSLVVERARNTPT"
     gene            complement(5649..6179)
                     /locus_tag="EZV63_RS37190"
     CDS             complement(5649..6179)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038493.1"
                     /locus_tag="EZV63_RS37190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /protein_id="WP_227730633.1"
                     /transl_table=11
                     /translation="MTAEDYAQTVPHHTVYGCLYIRDEHDRPIQLRSVYGSRLWQFPGG
                     NLDAPGEDPLQTARREAVEETGLGLGLGTPKLLLTHFLHAGPRLPLNKVGFIFDGGRLS
                     ADQIGRIRLDPDEHDMWAIHDLTTWQELMAPRAFARLDAVEQARRGEGPAYLVTHTCPS
                     MPAKEMPWPSDEL"
     gene            complement(6695..7888)
                     /locus_tag="EZV63_RS30010"
                     /old_locus_tag="EZV63_30450"
     CDS             complement(6695..7888)
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016805 - dipeptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579846.1"
                     /locus_tag="EZV63_RS30010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30450"
                     /product="M15 family metallopeptidase"
                     /protein_id="WP_194963075.1"
                     /transl_table=11
                     /translation="MVIRGNSASGKSSVAQGLRDHYGRGVAIVGQDVIRRNVLREHDTA
                     RGANIALLGRIARAALDAGFHVVLEGILYAERYGHMITSLVRDHRGASHCYYLDVPLEA
                     TLVRHASKADAAYLAQVTDSHLAAWYREMDLLPGALETVIPADSTLRDTIARILLETDL
                     ASASPIPPPQDKPSQGASMSKLVLMSDPQVAAVPVRECGEPLVDVRDHDFRVDPRKQDS
                     LGAFAHVREGVLARLEHARSLLPVGTDLLFIEGYRPLALQQRYFTEYRDQLAVAHPDWT
                     AEELQQNASRYVSPPEIAPHSAGAAVDVTLVDQDGRELDLGTRVNASPEESDGACFTHA
                     TNISDRARRHRTLLLDAMESAGFTNYGTEFWHFSAADRYDALMRQEPHARYGPIELR"
     gene            complement(7960..8652)
                     /locus_tag="EZV63_RS37195"
                     /old_locus_tag="EZV63_30455"
     CDS             complement(7960..8652)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523335.1"
                     /locus_tag="EZV63_RS37195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30455"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_228773833.1"
                     /transl_table=11
                     /translation="MTSAITQDEPPQPPKGTAPDGEPQDAGVREEVYLYRDEWFAPDDL
                     HRLRIADTTSDLVRRHAASLPAMPSDPKLEEQRPASPHGTVPNVIGVHLYLERSDGTVL
                     LGLRHPDSAFAPSTWHALAGHCEQENAITCLIREAREEAGLHIERQDVELVHVIHHIDK
                     AGDRPRMGLFFRVRAWSGEPELRELDKCTEWKFWYPTALPDNLVPYTRVAIAKIQNGEL
                     YSETGWPA"
     gene            complement(8884..9996)
                     /locus_tag="EZV63_RS30020"
                     /old_locus_tag="EZV63_30460"
     CDS             complement(8884..9996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346481.1"
                     /locus_tag="EZV63_RS30020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30460"
                     /product="hypothetical protein"
                     /protein_id="WP_166625306.1"
                     /transl_table=11
                     /translation="MIPAIASRVPLVRRTKAPALPLEERINHLTGLTVAPAGASHHDLV
                     ARTCGVLNYAALVASDVGLPDLAEDLCWRQHQVFANAGRLSGRIAVMSLMPLVNLARLQ
                     TRAGHGELAYSLLHCLNDAARHRNKTDIDGRTVDLSTLTGTDEDHRTVCQELYITLLVD
                     GARALAQVGRWTEAADAMARHRGIGNRLLDGRQIKIMALMEQGLDQQARDLIDTTQPTE
                     PWETAVALLLYAHCQPADVPVPETDLNRTVEEAVQLLAHPDPPTAVFQTRTGLSALELD
                     HAGRHHARILDSLRSVARLDAYAAREALHHPAASSALGHQATVALTAVIAAAGLGAGAL
                     SAHDHEALTGAVSHAERELERLLQADSDPG"
     gene            complement(10001..12046)
                     /gene="fxlM"
                     /locus_tag="EZV63_RS30025"
                     /old_locus_tag="EZV63_30465"
     CDS             complement(10001..12046)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346482.1"
                     /locus_tag="EZV63_RS30025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30465"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_166625307.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.3e-16, bitscore:
                     57.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.5e-41, bitscore: 141.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFDDENLPIPPLTSWWHASVAFADPHTAAARTLATALSGQRFHF
                     LRKDAGVRLRTEQPATGLLDQLVADRVITGWTGGIYEPETHAFGGPEGMQVAHDVFCAD
                     SPAALAETGTHGARERSVMLLSAMIREAGLDPFEAGDVYAQWAALRPPVTPPQGPALEQ
                     AVSAMRQLMNADAALRPDAEAGWVERVAAFEDAGRRLRRLAADGRLIRGVRGVIAHHAI
                     FAFNRAGIPADVQAATAWLGRHVAFSTGEGDDVSTRKSASADSSLPRMETTVPPVTDPN
                     QLREALAQRLVDSGHLRSQAAIDAFRTTDRHSFLPGVDLESAYKEDAVPIKHDEHGEMI
                     SCISAPSIVATQLEQLGAQPGHKVLEAGAATGYNAALLGRIISPGGQVWTLDVDQDLVA
                     GANKNLSEAGVDNATAVMADGAAGLPEHAPYDRIIFTVGAGDVPVKILDQLAPGGRLVL
                     PMRIRGSISRSFAFERDGETWKTVSCEMATFIPLRKGVCDDVYTLVPMAGEGTVRLETF
                     SEQDVDRDALRTVLDQQQTKIYTGVKFRQGSAWEWLYLYLACVLPNGLSRLPGQRPGFT
                     PHFGWGSMAALDGGSLAYLTIREGEDMQGRYWEVGVIGHGEGGAGLAERVVSEIRAWDA
                     TGGNDAPTPGFRMAVADSRDRLTASDPRFVVEKPYSRLVVDWARQG"
     gene            complement(12084..12674)
                     /locus_tag="EZV63_RS37200"
     CDS             complement(12084..12674)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="EZV63_RS37200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_228773834.1"
                     /sec_met_domain="LANC_like (E-value: 5.4e-25, bitscore:
                     86.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGGHGNNGMAHGIAGPLAVLSLALREGIRVPGQEEAVDTFVTWL
                     DRHGAHYWSTAAHLDADQPPAPEPARQSWCYGRPGIARAQQLAALALGDPARRRAAEDT
                     IETTLTDPLRLTRITDSTLCHGWAGLLTLTRAVAADSPAPDRFSPIIQDLHRRLATSWE
                     RLPKLGFMEGRAGAQLALQATDATGWSRALLLT"
     gene            complement(12727..13155)
                     /locus_tag="EZV63_RS37205"
     CDS             complement(12727..13155)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EZV63_RS37205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_228773835.1"
                     /sec_met_domain="LANC_like (E-value: 0.00073, bitscore:
                     17.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTGPRTQDLSEGALGMALLDIERRDLSTARRHLAQATARGVS
                     TGSNASLFHGAPALEFVLARAHGADDDVHAAVDRVVDARLAAAHRRQAAGALPHLAEWD
                     LIRGMTGLAALLLSRQPPAPRLPDVLTCLVALARPPPR"
     gene            complement(13152..15191)
                     /locus_tag="EZV63_RS30035"
                     /old_locus_tag="EZV63_30475"
     CDS             complement(13152..15191)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346484.1"
                     /locus_tag="EZV63_RS30035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30475"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_227730629.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2e-19,
                     bitscore: 68.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.1e-100,
                     bitscore: 336.4, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRHRPSLYEGAGQAMLRAAVHTTEPAMPPWPKFAAPAEQWRAWL
                     NSVWSDTDFRQTVAQASPHLAAQVRAIIDGHTPKARRMRRAALATARYAIRYARRSTPF
                     GLFAGVAPLAFDETTSVRIGDEHQAVARPEPALLDEMLSAWESDAARMADAEVCVNTLI
                     CQRDGHIHVPSEGDAAFRLALSPALRLVLDLARSPIGYRQLSDKLSAEFPAVDGTARDR
                     LLGELLRVRLLRSSLRAPATVADPTDVLPPTARTQAAGLRTACDLRLDADVRLPEQVLT
                     EAETAATVLARLVTHPNGTPTWRRWIEQFSERYGENTAVPVEVATAPGRGVGFPAGFVT
                     ASEPPRPMSRRDRLLLELAGTAAAEGSRTVTVTGAMIEELEAAVGGKPRDLAPHHELAA
                     QVHATSVPALDRGDFRLRVLTVSRSAGSMTGRFWHLFPGTETAYATLPTVDPEAELAQL
                     SFHAGRVAADLLTRAPQALPRIVSVGEFRRPAPHVLFPRDLAVTVADGRPQLVESATGK
                     PLELLAPTAINFLWNNYTPPMARFLGEISRAASPQVTWFDWGAAWTLPFTPALTYRRTV
                     LTAARWKIRSGTLPARTAPLQQWADQLHAWRARFRVPERVLLAEDDQQLPLDLSRDIDL
                     DLLRAHLDASPFGIATLQDAPPPDADGWIGGRAHSIVVPLARRS"
     misc_feature    complement(14442..14444)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(14472..14723)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EZV63_RS30035_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.90E-22"
                     /identifier="RREFam001.1"
                     /label="EZV63_RS30035"
                     /locus_tag="EZV63_RS30035"
                     /protein_end="240"
                     /protein_start="156"
                     /score="68.8"
                     /tool="antismash"
                     /translation="VCVNTLICQRDGHIHVPSEGDAAFRLALSPALRLVLDLARSPIGY
                     RQLSDKLSAEFPAVDGTARDRLLGELLRVRLLRSSLRAP"
     gene            complement(15299..15484)
                     /locus_tag="EZV63_RS30040"
                     /old_locus_tag="EZV63_30480"
     CDS             complement(15299..15484)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="EZV63_RS30040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30480"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_166625308.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.2e-16, bitscore:
                     57.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAIQAERPTGPAKTDLVKADDDPFKLDITFIEGTPATETALMCS
                     TGDTCGSSCPSACTTS"
     CDS_motif       complement(15362..15484)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTAIQAERPTGPAKTDLVKADDDPFKLDITFIEGTPATETA"
                     /locus_tag="EZV63_RS30040_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15299..15361)
                     /prepeptide="core"
                     /locus_tag="EZV63_RS30040_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.40"
                     /molecular_weight="1749.9"
                     /monoisotopic_mass="1748.7"
                     /core_sequence="LMCSTGDTCGSSCPSACTTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAIQAERPTGPAKTDLVKADDDPFKLDITFIEGTPATETA
                     "
                     /leader_location="[15361:15484](-)"
                     /alternative_weights="1768.0"
                     /alternative_weights="1786.0"
                     /alternative_weights="1804.0"
                     /alternative_weights="1822.0"
                     /alternative_weights="1840.0"
     gene            complement(15611..16078)
                     /locus_tag="EZV63_RS30045"
                     /old_locus_tag="EZV63_30485"
     CDS             complement(15611..16078)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491161.1"
                     /locus_tag="EZV63_RS30045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30485"
                     /product="DUF6082 family protein"
                     /protein_id="WP_166625309.1"
                     /transl_table=11
                     /translation="MKLTTAVLAAGAAVSLTTAVVGATRLRQNARHQAERNEAFLTRNQ
                     LDWLAQMSTNPDLAKLWAPEDMDVEEYMQLLAANRLICILSVRDRLGFVRTGHLPWHAA
                     KLMENDACRRYWQRFGDLRAEEAEGDEQGEHFTRVLDQAAKQHPRAQAAAT"
     gene            complement(16153..16728)
                     /locus_tag="EZV63_RS30050"
                     /old_locus_tag="EZV63_30490"
     CDS             complement(16153..16728)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491163.1"
                     /locus_tag="EZV63_RS30050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30490"
                     /product="DUF6624 domain-containing protein"
                     /protein_id="WP_166625310.1"
                     /transl_table=11
                     /translation="MTTDEPQRPDLARELIARATESAVHRARRVRDQLDAVQLGQGRHT
                     DHANTKFLRRVLGEYEWPGHRLVGPAAARAAWSIALHSDHDLTLQRAATILLGRAVQAD
                     DALVQHWAHLHDRALITGGCAQEYGTQLMLSAEGIELCPLRAPASVDARRATVGLPPLA
                     VALKAVRRRYTPDSSADEAPTVVLAGAA"
     gene            complement(16725..17288)
                     /locus_tag="EZV63_RS30055"
                     /old_locus_tag="EZV63_30495"
     CDS             complement(16725..17288)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325328.1"
                     /locus_tag="EZV63_RS30055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30495"
                     /product="hypothetical protein"
                     /protein_id="WP_166625311.1"
                     /transl_table=11
                     /translation="MRTLRTDAEREEAAALVQDRQRWLTLRGLPVPAQADVPALFRDPH
                     TTSAGLFEDGKLLACMVPARDPGLSWGEGPCLRLGRVHTLPEQPDDITRLITLWASDLA
                     ARQSLPLVRAEILARHALQAEPIAALLRRLTDMGWDVRGSGPGREGDRVARLELTAEHR
                     PRLSTLISCQTHAFHLAADDRSTA"
     misc_feature    complement(17277..17279)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17315..17331
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.59"
                     /tool="antismash"
     gene            complement(17372..17845)
                     /locus_tag="EZV63_RS30060"
                     /old_locus_tag="EZV63_30500"
     CDS             complement(17372..17845)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579865.1"
                     /locus_tag="EZV63_RS30060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30500"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_227730628.1"
                     /transl_table=11
                     /translation="MTTSAPITPLTPTLQRVAQHLANGLTAQEIATQTVLSPVTVRQYL
                     RDIRESLHCPPRCKPPVIVHRLFTTQQVVPPTADRPAPTLSPEQKLLLRAVAEHSDPRD
                     IAVAAKLAPADQRAALDQLLADTGARDTTHLVILAHGWKLLPTDPSARSGARQ"
     gene            complement(17983..19236)
                     /locus_tag="EZV63_RS30065"
                     /old_locus_tag="EZV63_30505"
     CDS             complement(17983..19236)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325326.1"
                     /locus_tag="EZV63_RS30065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30505"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_166625313.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 9.1e-21, bitscore:
                     73.4, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1e-18, bitscore:
                     66.1, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.5e-33, bitscore:
                     113.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATPTTPPPALRPYLTARHDLLWEEADAFAAEHVASRAARMEAA
                     PGRVERKVADLMAARGWFAVTVPAVFGGLGAGHVAKTVLVHRIARVSAAAAAILQATLI
                     PVGALLHFATYEQKGRWLPRVADGSLLLSIAVTEPLAGGHIGGIETTAERAGNEWVITG
                     SKIHIGNSHLAGAHLVVARTAAPGVSTSQALTAFMVEADRPGLSVSDHRAGLGLHGFSV
                     GRLGLDHVRVPAGNVVGEIGQGLAVAQSSSILYGRPNLAAVSLGIHEAVVDTTTARLKA
                     RPRYQGALSDLPVLRDRVGGMEARLRAARILAYQSVHLLDQGLPCDAELINAKYLGHQW
                     AVQSAQDAMELHGAHALDGDYIVQRLWRDIQHTYPPAGTGEVQRIRLADAAFAEDHIQW
                     SERLAAEAAWAHPDPTAA"
     gene            complement(19321..19962)
                     /locus_tag="EZV63_RS30070"
                     /old_locus_tag="EZV63_30510"
     CDS             complement(19321..19962)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325325.1"
                     /locus_tag="EZV63_RS30070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30510"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_166625314.1"
                     /transl_table=11
                     /translation="MSQHPSTPYRTPQTAPPAGSLPRRDMRDTNRGPFTPPGTALTSQR
                     PQQSLELAQRYELLNRLGVPLVANEDFDEMATAMAEQAGFLYGFVNLGLEKQTFVGLHQ
                     PPAGSGYVIVGRTMSRDHGWCPEVMTRKKALPLHDVHASPRFSGNAVVDAVGIRSYFGA
                     PLIHESGTVLGTVCVIDPEKRPLREARRIRDITINTGAQVMDHMSRALVR"
     gene            complement(19962..20552)
                     /locus_tag="EZV63_RS30075"
                     /old_locus_tag="EZV63_30515"
     CDS             complement(19962..20552)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491174.1"
                     /locus_tag="EZV63_RS30075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30515"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_166625315.1"
                     /transl_table=11
                     /translation="MLKIVIAGGFGAGKTTAVGAVSEITPLSTEEYLTEASADVDSLAG
                     IEAKQTTTVAFDFGRLSLPNAPIPLELFLFGTPGQDRFVDLWYDLSRGAVGAVVLVDTR
                     RLESSFTPVSFFEDIGLPFVVAVNQFDGAHRYHPEQVRAALELPAAVPVVTCDARDTNH
                     VAGVLLALVDHAVNSAATTNRTGHAPSTPLQDA"
     gene            complement(20605..21012)
                     /locus_tag="EZV63_RS30080"
                     /old_locus_tag="EZV63_30520"
     CDS             complement(20605..21012)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491176.1"
                     /locus_tag="EZV63_RS30080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30520"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_052837028.1"
                     /transl_table=11
                     /translation="MTTYGRAAEESAFVRTYTVVRGRTRPRHLLALETVLEAGQGRPGP
                     AQAEECEEILALCRERRRSVVELAGRLGRPVSAVKVLVSDLLDADALVVPLTHSYADTG
                     AGSGPSTQLLAAVTAGLKRKWPDAVAYPQAG"
     gene            complement(21009..21524)
                     /locus_tag="EZV63_RS30085"
                     /old_locus_tag="EZV63_30525"
     CDS             complement(21009..21524)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031324.1"
                     /locus_tag="EZV63_RS30085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30525"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_166625316.1"
                     /transl_table=11
                     /translation="MSTHPAMKNVTDGNAAFATTPSGQRDSMVWLLRQFASETQGVTHA
                     VLLSRDGLRLLDSDVDKDWADELSAAFSGVASLAANITGPSHKKRPARQVIIERDDCLF
                     FVQSAGCSAAFDNHPGNERGEVDTILAVIATRNADVGTVGFEMGRLVAKFAPYMVIPVR
                     VGTGGEVR"
     gene            complement(21591..23108)
                     /locus_tag="EZV63_RS30090"
                     /old_locus_tag="EZV63_30530"
     CDS             complement(21591..23108)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491180.1"
                     /locus_tag="EZV63_RS30090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30530"
                     /product="ATP-binding protein"
                     /protein_id="WP_194963077.1"
                     /transl_table=11
                     /translation="MPDSAFPARPAATGHRRRRPPVDATTLYLARRAVALPLALLAALL
                     LAAFALRSGSVVGPGWVLAGMVCGLAAVVAMATHGTRTVASAVQSAVEESQSAALTAVT
                     GAAAAVEKSVQWSADELCRGKRPALPDPHTAQSPTANAGIDNALSALQAQSIMSLIRVH
                     DESQSVVLLEVLRRLAMREHALVSKALQALSQLEMLTDDPELLAKIFEIDHLVTRMRRQ
                     VESTAVLGGQSLRSVRRPVPVTTALRGAVSEVVQYPRVAVAAGSVGAELGLPGHVGPDL
                     THLLAELIENACECSDPETRVMVRAQRVPHGLAIEVEDRAIPMHPQTRAQMNHLLKAPD
                     EVDVSGQVRAGQLGLLVAAKIAQSHGMTVLLQENTTGGTTALVVIPARLLVAIPSVEDA
                     GAPPSEEARGSGRQPQQVAVTPAVPEAAQAARRGVGEAPTAEAGQSTDAPALPTRTRRT
                     GSFRPPQEREQAPVSAATPGLAAAFRNGLQAGGSASPSPAWTEQPTP"
     gene            complement(23135..25036)
                     /locus_tag="EZV63_RS30095"
                     /old_locus_tag="EZV63_30535"
     CDS             complement(23135..25036)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491181.1"
                     /locus_tag="EZV63_RS30095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_30535"
                     /product="glycoside hydrolase family 15 protein"
                     /protein_id="WP_166625317.1"
                     /transl_table=11
                     /translation="MKRLPRIEQYGLIGDTQTSAHVCDDGTIDWLCLPRFDSPAVFAGL
                     LGTQKHGTWQIAPASSAGWSGSGRVAERRYRGDSLVLESLWRTPTGSVRVLDFVPPRDG
                     APQVIRIAEGLTGEVEMVSAMRPRPGYGSVNPWIHEVGGRMVAEAGADALWLDTCVPQV
                     EKDGVVVSVFTVGAGQSVAFLLSWCPSHAAAPDVHDAHAALAQTLAFWQDWVQECTYDG
                     PYREAVVRSAITLKAMTYGPSGGIVAAPTTSLPEEIGGDRNWDYRFTWLRDAATTLAAL
                     LGTGYRQEAQAWRRWLLRAVAGDPENLQIMYGITGERDLRERELPWLPGYEGSAPVRVG
                     NGAADQLQLDVYGEVIDTLYLAHRSGVAHCADTAVLHQRLIEHLVQRWREPDEGIWEIR
                     GARRHFVHSKVMAWVAVDRTIRLAEAGALNIDVAPLVELRAAIHREVCDKGFDPVRNAF
                     TQSYGSQELDAATLLIPRTGFLPPDDPRVIGTVDAVRRELSTEDGLVYRYPTCGEEVGV
                     DGLTGDEGAFFLCNFWLVDGLALTGRPDEACALFERLLALRNDLGLLAEEYDPVQQRQL
                     GNFPQAFSHMGLIQSALLLQQMATQSSPRHGALAVPAPRSASRSTRQSTADLTPQHA"
ORIGIN
        1 catccccggc acaccgtacg acgcgacctg tgtgctgatg ttcacgatga cacccttgcc
       61 gcgctcggcc atcgccggtg ccagctcggc gacgaggaag aacttcgcct tcacattgag
      121 gtcgtagacg gcgtcgaact cttcttcggt cacctcatgg gtggggcgga acgggtacgc
      181 acccgcgttg ttgacgagga tgtccacccg gcctccgcct gcctggcggg cgcgctgtgc
      241 cagtgaccgt gcggatgcgg cgtcgcgcag gtcggccgcg aggaagtcgg ctttcccgcc
      301 acgtctgcgg atcgcggcca ctgtgtcctc gccgcgtacg gtgttgcggc ccgccaccag
      361 gacgtgagcg ccgtgttcgg cgagcgtcgc cgcagtcgcc gcgccgatgc cgctggttgc
      421 tccggtcacg agggctacgc tgccgttcga gagggggaaa gtcatcgcat gtccttcggc
      481 ctggggtcgg tgtatcaggg gtgcgtggag atgaaatggc gagcgctggg cggcccggca
      541 cgggcacacg gcacccgtga gggctaacag gtgcggagtt cgggcggcag cgagtgctgc
      601 tgccggtggg tcagccggtg ctcgcgccgc cgtcgacgcg caggatctgg ccagtgatgt
      661 gtgcggcttc ctgcgagagc aggaagcaca cggccgcggc gatgtcgtcc ggccggccca
      721 gccgcccgga gggtgtgccg gcgaggtatc gctgctccga ggcggacccg gctggattgt
      781 tggcacggaa cagttccgtc tcggtgggtc cgggggcaac ggcgttgacg gtcactcccg
      841 tcgtggcgag ctcgcccgcc caggctcggg tgcagaagtc cagcgccgct ttggccgctc
      901 cgtaagccgt gcgttccggt ttgcccacgg tgaccaggct ggtgatgttg acgatgcggc
      961 cccaaccgtg cgcggtcatg gctggcaggg tggcctggac ggcttgcacg gcgacccgca
     1021 ccgtcatgtc gtagaccgcg tgcagatcgt ccagctcgac ttcgtgtacg gatgcgggtc
     1081 gaaccaggcc gacattgttg actacagcgt cgacggggcc ctgggcgagg acggcccgaa
     1141 gggctgtgtc cgtggctgcc cgatcggaca ggtcgacctc gtggaagtcc ccggggaagg
     1201 cgtcggtcga ggtccgtgcg aggccgatgg gccgatgccc ctggcgggcc aggcgttcgg
     1261 ccaccgccag gccgatgccg cgtgaggctc ctgtgatgag cacgcgtcga gaggccatgg
     1321 tgagaagagg tcctttctcg tccccgcatc gcagggcggt tgctactgcg gtgcggggag
     1381 gggcgaaggc catgggtggc cgatgccagg gggctatcgg ccacctgcgg ccgggcgagg
     1441 tcaaaagccg ggaaagaggg ccgtcaggtc ggtcagggtg acagcgccgc tcacctggac
     1501 ttcgtccgtg ggctggtggc ggccgtagac gagacgcaac acagcctccg ctgcgcccgt
     1561 gacggagccg actggttcgg ccggctcaca cgggtacagg tgcagctcgg caccgaggtc
     1621 cagcagcacg gtccgggccg ggctggtcag ggcgatcgtg agctgcgccg gagcgagccg
     1681 ggcgagagtg gtggcgtcac ggaagcgggt ggcgaccagg tccagccgct cccacaacag
     1741 ttccacctct cccgccggaa tcgtcgcgcc cggagtgagg acggcttcga cgtcccaggc
     1801 gtggactgag tgttccgaca gccggtaccc ggcgtagtcg gggaggttga gcaggccggc
     1861 aaagtacgga acacgcaccc acagctgctg ggacatgccc agcgagtcca gaagctgcag
     1921 gtgtcgcgta tcagcttcct gccacgcctc ccgctgtgcc ggcggtggca gcgtgttcca
     1981 ccgctgccac accggctcca ggtcctcccg taccggcccc ctctcatcgc ccgcgatgcc
     2041 acgctcaagc aggccggtgg agatctcggc ggcgctgccg agatgggaca acacctgcgc
     2101 aatgctccat ccgctggcca tcgagggctg ttgcagctcc cgctcggaca gggaagcaac
     2161 ggtgtcggtc aggcggcggg agcttgtgtg gagggcttcg agccagacct gcaggctccc
     2221 ggccgcatcg gtgggggagg gtgccaccac gtcctcgctc attactgctg gtaggcgagg
     2281 tcggcggcgg tgaggccctc gagagccatg ccgagctgaa gaccttcggc catgcggcgg
     2341 ctgatgcgct ggcgcagggt gacggcgagg tagcgggtga gcagctgcgg cttggcggcc
     2401 agaccctctg cgagctgctg ggcgcggggc aggacctgcg ccagcgggag tacctcggcc
     2461 accgcgcccc agcgctcggc ctgctcggcc gtgaaggagc cctgcgtcag ggtcagatag
     2521 cgggcccggt tgacgcccag ggcctcctcc caggcgatct ggatgccgtc cccggggacg
     2581 atgccgaagg tcagatgggg gaagtcggag aagacggtcg tgtcggcggc gatgacgatg
     2641 tccgccagca gggcgtactc gctgtggacg gacgctggac cgttgaccgc ggcgatgacg
     2701 ggcatctcca ggtcgaccag gcgctggagg acgcggcggc cctcggcgac agtgcggtcc
     2761 cactgggcgg gcttggtgat gtcacccagg ctggcgccgt cgatgtcggt catgaaccgg
     2821 tccccggtgc cggtcagcac cagcacccgg ttgtcgcggt cctcgccgat ctcgaagaga
     2881 gcacgaggga agtcggtgtg cgtctgaccg gtgaaggtgg ccggaccgtc gtcggtgtgg
     2941 aaacgcagcg tgagcacgcc cgcctccgta cggctcatcg ccaggttctt gaacgcggtg
     3001 aagtaggaag ggttctgctg ggacacggaa ggctcctgaa gcgatctcgg gcggtctatc
     3061 cgccgcgtgt tcctactcaa ctcctgccgc agcaacatgc atagtgcctg gccagagggc
     3121 ttgccgaggg cggccataag catgggtaat ggcaccgtgc ggggtttacc gccgcgcgcc
     3181 tcaggtgctg gccgggttcg cgtgctacac cgacagctac ctcgccatca ctctgtggaa
     3241 cacgcgtgac cccgccgctc gctgctcgtg atgcgatagg ggcatggaaa tccgagcgat
     3301 gcgtgcgttc gtcaccgtgg tggaagaagg cggcctgtcg gcggcggcac gacggctaca
     3361 catcagccag cccgccctgt cccagaccat gagcgccctg gaacgcgaat tcggtcagca
     3421 gctactgatc cgctcctcca cgggcgtaca agccacggac accggcctgc tgctgctcgc
     3481 ggaatcccgt gccgtactgg cccgctacga ccaggcactc gcggtcatga ccgcgcgcac
     3541 cggggagagc gcgaccacgc ttcggatcgg catccccctg gaactacccg ccgacctgct
     3601 gtccaaggca ctgctcgaac tgtccgccgc ccaccccgac acgcgggtcc aagcccggca
     3661 cctgtccacc tcggcgcagg tcacggaact gcaccggggc aaccttgagc tgggcctgct
     3721 acgagaacgt ccccaggggc aggaactcga cgccatgctg gtcgtcaagg agcacctggg
     3781 tgttctgctc gcggccgagc gtgccgcaga gctggccggc cccggcggca tccgcctgga
     3841 cgcgctgaac gcactcgcct gggtcggttt cccccgctcc ggcagccccg cctggtacga
     3901 cgaactcacc gccatcctgc gcagccacgg tatcgaccca ggcccacagg tccccgatgg
     3961 ccagccactg atcgccgagg tcaaactcgc ctccgtcagc gccggacgcg ccttcaccct
     4021 ggcaccccca ggctggtccc aacccctgcc caactccgtc acctggttcc cgctggtagg
     4081 ccaccccatc gtccggcgca cctgggccgt gtggaacgca ggctcccacc gccgcgatct
     4141 cggccacctg gtagcggccc tggaccagcc cgccaggaaa gcagtgtccg acgcgacgcc
     4201 ctgacgcatg cagccctcca gccgagacgg aggacggacg ggacgaggga cgaccacgga
     4261 gaaccctgtc cacgatttcg gcccggggct ccgggcttcg atgggctgcc gcgcaacggc
     4321 gagccgaact gcaagcggtc ttgttaagcc tgcacattgc acaagccaaa accgcgtctt
     4381 gctcgacgaa agacaatgcg ggagccccag gggcgatcat ggggtcgagg ggcgcgtctc
     4441 cgtccagtcg accatcagcc gtcgttcggc gaagagccac ttgcccgccc cggcccggtg
     4501 ggcggccacc agcgcggcct cggaccggtc attccgcaag ttccaatagc ccgggttacc
     4561 aatatcctcg gcgggcacgg ttgcctcctg agtggggatg ccggggttag gtgggcgtgt
     4621 tccgggcgcg ttcgacgacc aaggaccagg aagctatggc gcttgtgcgg cgatgcaagc
     4681 cctcgatcag cttgcgacgg gagaggtcga cgatgaccgc gtggtgatcg ctgagcccgg
     4741 tggtatccag cacgcggacg tcttcgacgg cctgcacgct ccaggcatcc agatagccgc
     4801 ggtcgattct ccgggggcca ccctgaccgg cggcagcatg cccggcggtc gcagccaggg
     4861 cggtggtctg gcccaggcgg tgtgcggccc agcgggcggg gtcgtgcatg ccgcagtcat
     4921 gcatgatctc gtccaccgcg gtgcaactga cccaggtgca gtcgggttgc ttgatggcac
     4981 ggtgccggcg gtgcaccacg tcggtcaccc ttgaccagtc aatggccggg acctgctcgc
     5041 cgacgggcac cgggtactcg ttggtgtcgc cgaacaacca gcaggcggcg tgcccccttg
     5101 cgggattcgt ctggtgggcc ttcaccttgt cgacgagttc cgtcaagtcc atggcttcgg
     5161 agcggcgttg tgcggggttg cagaaggcgc tgtgcaaaga ggcggtgatg atgggcacgt
     5221 ccggggcctc ggggatccgc agttcgacgt gggtaggcgg tgcactgtgg ccgacggggt
     5281 ggtgacgctg gcgggcagag ggaaagacgg cctcgcgtat gaacacaccg gtgggattgg
     5341 tgcgctgccc taccgcggca cggaagccgc gcataccgag gatctgctgt gcggccgtga
     5401 aacggcgctt cgccgcgtgc ttctccgccg gtggcacgtc aggccgggtc tgtgagtatt
     5461 tgagttccag catggccagc caatctggcc gctgtggctt caggacctct tcgtagccct
     5521 ggcgccaccg ttccggcagg acgccgggcc ggggctccgg gcctccgtcg cgctccagat
     5581 tccacagcat gagccggatg cggtcctgcg tgttcacgtc tacctccacg gatgatgaga
     5641 acggccagtt acaactcgtc cgacggccag ggcatctcct tcgcgggcat gctgggacag
     5701 gtgtgggtga cgaggtaagc ggggccctcg ccgcggcgtg cttgctcgac ggcgtcgagg
     5761 cgggcgaagg cgcggggtgc catcagctcc tgccatgtgg tgaggtcgtg gatggcccac
     5821 atgtcgtgct catctgggtc gaggcggatc cggccgatct gatccgcgct cagccggcct
     5881 ccgtcgaaga tgaaccccac cttgttcagc ggcaggcggg gcccggcgtg caggaagtgc
     5941 gtcaggagca acttcggcgt gcccagtccc agtccgaggc ccgtctcctc gaccgcctcg
     6001 cgccgggcgg tctgcagcgg gtcctcgcct ggggcatcca ggttgccgcc tgggaactgc
     6061 cagagtctcg aaccgtagac cgagcggagc tggatgggcc ggtcgtgctc gtcgcggatg
     6121 tacaggcagc cgtagacggt gtggtggggg acggtctgcg cgtaatcctc ggccgtcatc
     6181 ggcatggagc gccctggccg ggcagggcga tggtcgaacg tgaaggcgag aacgccgagc
     6241 gcttccttga cgggcgggta gatgctgcgg agggcggcga gcaccgcccc gggcggtcgg
     6301 tccgggtcga tgtgcgcggg atcctccgag ccgagtcctt gaaggagggg tacgaggtga
     6361 tccgttgcac ggtgacgtcg agttcccggc cggtgtcccg gtcgtggaag acgaccgtgt
     6421 cgccggcggc gacggtccgc ttgtccgggg tggccaccct gacctcgatc gtcttgcggc
     6481 ctgcctccac ttggcggtag taccgcccga gcaggtgcat atggtgctct tgcgggccgt
     6541 ttccgctggc cgggctcggg ctggccgcgg tcgcctgttg gatgtcgtca ggcacacgtg
     6601 cctccgttcg atgccttgcg tctgttgccg gtctggccgt cgtaaccggg ccagggtgtg
     6661 gtggccgcgc tcccgtggcg gggctgtggg cgggctagcg cagttcaatc ggtccatagc
     6721 gcgcgtgcgg ttcctgccgc atcagggcgt cgtaccggtc tgctgccgag aagtgccaga
     6781 actcggtccc gtaattcgtg aagccggcgc tctccatcgc gtcgagcagc agcgtgcggt
     6841 ggcgacgcgc acggtcgctg atgttcgtgg cgtgcgtgaa gcaggccccg tcgctttcct
     6901 ccggggaggc gttgacgcgg gtgccgaggt cgagttcgcg gccgtcctgg tcgacgaggg
     6961 tgacgtccac ggccgcgccc gcggagtggg gcgcgatctc cggcggcgac acgtaccggc
     7021 tggcgttctg ttgcagctcc tcggcggtcc agtcagggtg ggcgacggcc agctggtccc
     7081 ggtactcggt gaagtagcgc tgctggaggg cgagcggccg gtagccctcg atgaacagga
     7141 ggtcggtgcc gacgggcagg agcgagcggg catgctccag gcgcgccagg acgccctcgc
     7201 ggacgtgggc gaaggcgccc agcgaatctt gcttacgcgg gtcgacacgg aagtcgtggt
     7261 cccgtacgtc gacgaggggt tccccgcact cgcgcaccgg gactgcggcg acctgcgggt
     7321 cggacatcaa caccagtttg ctcattgagg ctccctgtga cggcttgtcc tgcggcggcg
     7381 ggatggggga ggcagaggcg aggtcggttt cgagcaggat tcgcgcgatg gtgtcccgga
     7441 gcgtgctgtc agccgggatc acggtttcca gagcgccggg cagcaggtcc atctcgcggt
     7501 accaggcggc gaggtggctg tcggtgacct gggccaggta tgcggcatcc gccttcgacg
     7561 cgtgccgcac cagcgtcgcc tccagcggaa cgtccaggta gtagcagtgg gaggcgccgc
     7621 gatggtcccg taccagcgac gtgatcatgt ggccgtagcg ctcggcgtac aggatccctt
     7681 ccaggacgac gtgaaagcct gcgtccaggg ctgcgcgggc gatccggccc agcagggcga
     7741 tgttggcgcc gcgcgcggtg tcgtgctccc tgagcacgtt ccggcggatc acgtcctggc
     7801 ccacgatcgc gacaccgcgg ccgtagtgat cgcgcaggcc ctgggccacg ctggacttgc
     7861 ctgacgccga gttgccgcgg atcaccacga ggcgggtatc ctcccggccg accgcagctg
     7921 ttgtggacac acgacggggt gcgccgctcg gggtgccggt cacgcgggcc atcccgtctc
     7981 gctgtacagc tccccgttct ggatctttgc gatggccacc cgggtgtagg ggacgaggtt
     8041 gtcggggagc gcggtggggt accagaattt ccactcggtg cacttgtcca gctcgcgcag
     8101 ttccggctcg ccactccagg cgcgaacgcg gaagaacagg cccatgcggg gccgatcccc
     8161 ggccttgtcg atgtggtgga tgacgtggac gagttcgacg tcctgacgct cgatgtgcag
     8221 ccctgcttcc tcacgtgcct ccctgatcag gcacgtgatg gcgttctcct gctcacagtg
     8281 gccggccagc gcgtgccagg tcgagggcgc gaacgcggag tcggggtggc gcagcccgag
     8341 cagcaccgtc ccgtcggagc gttccaggta gaggtggacg ccaatgacgt tggggaccgt
     8401 gccgtgcggt gacgccggac gctgttcttc gagcttgggg tcgctcggca tcgccgggag
     8461 gctggcggcg tggcgccgta cgaggtcgct ggtggtgtcc gcgatgcgca ggcggtggag
     8521 gtcgtcgggg gcgaaccact cgtcgcggta gaggtatacc tcttctcgaa caccggcatc
     8581 ctgcggttcg ccgtccggcg cggtcccctt gggcggttgc ggcggctcat cttgcgtaat
     8641 agccgaggtc atcgttcccc ctagggcggt cgctacggca gagtcgtgag gtctaacgac
     8701 gcggtggcga tatcgaacac acgtcattcg gtcgtgctgg aaagcccgtg attccctgcg
     8761 tctgtggagc ccgcaggcgc cacatccctg gtctggcttg gagcggctgc gggcaggaaa
     8821 tggccgaaac accgacaccg ccgcaccgcg cagtacgcct gggcaccgca ggtcacccgc
     8881 ctcctaaccg gggtcagaat cggcctgcag cagcctttcc agctcccgct cggcgtggct
     8941 gaccgcgccc gtgagggcct cgtggtcgtg cgcggacaga gcgccggctc ccagtccggc
     9001 cgcggcgatc actgcggtca gtgcgaccgt cgcctggtgg cccagagctg acgaggcggc
     9061 ggggtggtgc agagcctctc gtgcggcgta ggcgtcgagt cgggcgacgc tgcggaggga
     9121 gtcgagtatc cgggcatgat ggcggccggc atggtccagt tccagggccg acaggcccgt
     9181 gcgggtctgg aagacggcgg tcggcggatc gggatgggca aggagctgga cggcttcttc
     9241 cacggtgcgg ttgagatcgg tttcggggac gggaacgtcg gcaggctggc agtgcgcgta
     9301 caggaggagg gcgacggccg tctcccaggg ttctgtgggc tgggtggtgt cgatcaggtc
     9361 gcgggcctgc tggtccaggc cctgctccat cagggccatg atcttgatct ggcggccgtc
     9421 gaggaggcgg ttgccgatgc cgcggtgccg ggccatggcg tcggcggcct cggtccaccg
     9481 cccgacctgg gcgagggcgc gggcgccgtc cacaaggagg gtgatgtaca gctcctggca
     9541 caccgtgcgg tggtcctcgt ccgtgccggt cagggtcgag aggtcgacgg tgcggccgtc
     9601 gatgtcggtc ttgttgcggt gccgggcggc gtcgttgagg cagtgcaaca agctgtaggc
     9661 gagttcgccg tggccggcgc gggtctgcag ccgggcgagg ttgaccagcg gcatcagcga
     9721 catgaccgcg attcgtccgc tgaggcgtcc ggcgttggcg aagacctggt gctggcgcca
     9781 gcacagatcc tcggccaggt cgggcaggcc gacgtcggag gcgacgagcg ccgcgtagtt
     9841 gaggaccccg caggtgcgag ccaccaggtc gtggtggctc gcacctgcgg gcgcgacggt
     9901 cagcccggtg aggtggttga tgcgctcctc caaggggagc gcgggcgcct tggtgcggcg
     9961 gaccagggga acgcggctgg ctatcgcggg gatcatcggc tcagccctgg cgcgcccagt
    10021 cgacgaccag tcggctgtat ggcttttcga cgacgaagcg agggtcgctg gccgtcagcc
    10081 ggtcgcgtga gtcggcgacg gccatccgga agcccggtgt gggggcgtcg ttgccgccgg
    10141 tcgcgtccca ggcgcggatc tcgctcacca cgcgctcggc gaggccggcg ccgccctcgc
    10201 cgtggccgat cacgccgacc tcccagtacc ggccctgcat gtcctcacct tcccggatgg
    10261 tcaggtatgc gagcgacccg ccgtcgaggg ccgccatgga gccccacccg aagtgcgggg
    10321 tgaaccccgg gcgctggccc ggcaggcggg agaggccgtt gggcagcacg caggccaggt
    10381 acaggtacag ccactcccac gccgagccct gccggaactt caccccggtg taaatcttgg
    10441 tttgctgctg gtcgaggacg gtacgcaagg cgtcgcggtc gacgtcctgc tcgctgaacg
    10501 tctccaggcg cacggtgccc tcgccggcca tcggcaccag cgtgtacacg tcgtcgcaga
    10561 cgcccttgcg cagcgggatg aaggtggcca tctcgcagga gacggtcttc cacgtctctc
    10621 cgtcgcgttc gaaggcgaag gagcgggaga tgctgccgcg gatacgcatc ggcaggacca
    10681 ggcgcccgcc gggggcgagc tggtcgagga tcttcacggg gacgtcgccg gcgccgacgg
    10741 tgaagatgat ccggtcgtag ggggcgtgct cgggaagtcc ggccgcgccg tcggccatca
    10801 ccgcggtggc gttgtcgacg ccggcctcgg agaggttctt gttcgcgccg gcgacgaggt
    10861 cctggtcgac gtcgagggtc cacacctgcc cgccggggga gatgatcctt ccgaggaggg
    10921 cggcgttgta gccggtggcg gctccggctt ccaggacctt gtggccgggc tgggcgccga
    10981 gctgttcgag ctgggtggcg acgatggacg gagcggagat gcaggagatc atctccccgt
    11041 gctcgtcgtg cttgatcggg acagcgtcct ccttgtacgc gctctccagg tcgacgccgg
    11101 gcaggaagga gtgccggtcg gtggtgcgga aggcgtcgat ggccgcctgg ctgcgcaggt
    11161 ggccgctgtc gacgagccgc tgggcgaggg cttcgcgcag ctggttgggg tcagttacgg
    11221 gtggcacggt ggtctccatt cgggggaggc tagagtccgc cgaggcggac ttgcgggtag
    11281 acacgtcatc tccctctccg gtggagaagg cgacgtgacg gccgagccac gcggtggcgg
    11341 cctgcacgtc ggcaggtatg ccggcgcggt tgaacgcgaa gatcgcgtga tgggcgatga
    11401 cgccccgaac tccgcgtatc agtcggccgt cggcggcgag ccggcgcaga cggcggccgg
    11461 cgtcctcgaa cgcggcgacg cgctcgaccc agccggcttc cgcgtcgggg cgcagggcgg
    11521 cgtccgcgtt catcagctgc cgcatagccg atacggcctg ctccagcgcg gggccctggg
    11581 gcggggtgac ggggggccgc agggcggccc actgggcgta gacgtctccg gcttcgaacg
    11641 ggtccagccc ggcctcgcgg atcatggcgg acagcagcat cacgctgcgt tcgcgggcgc
    11701 cgtgggtgcc ggtctcggcg agcgcggccg ggctgtcggc gcagaacacg tcgtgcgcga
    11761 cctgcatgcc ttcggggccg ccgaatgcat gggtctccgg ctcgtagatc ccgcccgtcc
    11821 agccggtgat gacgcggtcg gcgacgagct ggtccagcag accggtggcg ggctgttcgg
    11881 tgcgcaggcg cacgccggcg tccttgcgca ggaagtgaaa acgttgcccg gacagcgcgg
    11941 tcgccagggt ccgagcagcg gccgtgtgcg gatcggcgaa ggccacggat gcgtgccacc
    12001 aggacgtgag cggagggatc ggcaggttct cgtcgtcgaa ggtcatggag gggtaactcc
    12061 ttgcacgtcg gcaggttcgg gggtcaggtg agcaggaggg cgcggctcca gccggtggca
    12121 tcggtggcct gcagggcgag ttgggctccg gcgcggcctt ccatgaagcc gagcttgggc
    12181 aggcgctccc aactggtggc cagtcgtcgg tgcaggtcct ggatgatcgg gctgaagcgg
    12241 tcgggtgcgg ggctgtcggc ggcgaccgcg cgggtgagag tcagcagccc ggcccagccg
    12301 tggcagagcg tggagtcggt gatgcgggtg aggcgcagcg ggtcggtcag ggtggtctcg
    12361 atggtgtcct cggccgcccg gcggcgggcg gggtcgccga gggcgagcgc ggcgagctgc
    12421 tgggcgcggg cgatgccggg ccggccgtag caccaggact ggcgggccgg ctcaggcgcg
    12481 ggcggctggt cggcgtccag gtgggctgcg gtggaccagt agtgggcgcc gtgccggtcg
    12541 agccaggtca cgaaggtgtc gacggcctcc tcctgaccgg ggacgcggat gccttcgcgc
    12601 agggccaggg agagcacggc aagaggcccg gcgatgccgt gagccatgcc gttgttgccg
    12661 tgcccgccgg tcatctcctt cccgtcgggg ccgaccggcg accaccaccc gggcagtatc
    12721 cggccgtcac cggggggggg gacgggcgag ggcgacgaga caggtgagca cgtcgggcag
    12781 ccggggcgct ggcggttggc gggagagcag gagggcggcg agaccggtca tgccgcggat
    12841 gaggtcccat tcggcaaggt ggggcagcgc gccggccgcc tggcggcggt gggcggcggc
    12901 gagccgggcg tccacgacgc ggtcgacggc cgcgtggacg tcgtcgtcgg ctccgtgggc
    12961 gcgggccagg acgaactcca gggcgggtgc gccgtggaag aggctggcgt tgctgccggt
    13021 gctcacccct cgggcggtgg cctgggcgag gtggcgtcgt gcggtggaca ggtcccggcg
    13081 ctcgatgtcg agcagggcca tccccagggc gccttcggac aggtcctgcg tgcgaggccc
    13141 ggtcgtcgtg gtcatgagcg cctggccagg gggacgacga tgctgtgggc ccggccgccg
    13201 atccacccgt cggcgtccgg cgggggcgcg tcctgcaggg tggcgatgcc gaaggggctg
    13261 gcgtccaggt gcgcgcgcag gaggtccagg tcgatgtcgc gggacaggtc gaggggcaac
    13321 tgctggtcgt cctcggcgag caggacccgc tccggcaccc ggaaccgggc acgccaggcg
    13381 tggagttggt cggcccactg ctggagtggt gcggtgcggg cgggcagcgt gccgctgcgg
    13441 atcttccacc gagcggcggt gaggacggtg cgccggtagg tgagggccgg ggtgaagggc
    13501 agggtccagg cggcgcccca gtcgaaccag gtcacctgcg gggaggcggc ccggctgatc
    13561 tcgccgagga agcgggccat cggcggggtg tagttgttcc acaggaagtt gatggcggtg
    13621 ggggccagca gctccagcgg cttgcccgtc gcggactcca ccagctgggg gcggccgtcg
    13681 gcgacggtga ccgcaaggtc gcgggggaag aggacgtgcg gggcagggcg gcgaaattcg
    13741 ccgacgctca cgatccgggg cagggcctgg ggcgcgcggg tgagcagatc ggccgccacc
    13801 cgcccggcgt ggaaggagag ctgcgcgagt tccgcctccg gatcgacggt gggcagggtc
    13861 gcgtacgccg tctcggtgcc ggggaagagg tgccagaacc ggccggtcat cgatccggct
    13921 gagcgggaga cggtcagaac gcgcagccgg aagtcacccc ggtccagggc agggacggag
    13981 gtggcgtgga cctgtgcggc cagttcgtgg tggggcgcca ggtcgcgagg cttgccgccg
    14041 accgctgcct ccagttcctc gatcatcgct ccggtcaccg tgacggtgcg gctgccttcg
    14101 gcggcggcgg tgccggccag ctccagcagc aggcggtcgc gccgggacat cggcctgggt
    14161 ggctcgctcg ccgtgacgaa cccggccggg aaacccacgc cccggccggg ggccgtggcc
    14221 acctccaccg gtaccgcggt gttctcgccg tagcgctcgg agaactgctc gatccaccgg
    14281 cgccaggtcg gtgtcccgtt cggatgggtg accaggcggg ccaggacggt cgccgcggtc
    14341 tcggcttcag tcagcacctg ctcgggcaac cgcacgtcgg cgtctagccg cagatcgcac
    14401 gccgtgcgca ggccggcggc ttgagtgcgc gccgtgggcg gtaagacgtc ggtggggtcg
    14461 gcgacggtag cgggcgcgcg cagcgaggag cgcaacagcc gcacccgcag cagttcaccg
    14521 agcagccggt cacgcgcggt gccgtccacg gcggggaact ccgcggacaa cttgtcggac
    14581 aactggcggt acccgatggg cgatcgggcc aggtcgagca cgagacgcag cgcggggctc
    14641 agagccaggc ggaaggcggc gtctccctcc gagggcacgt ggatgtggcc gtcgcgctga
    14701 cagatcaggg tgttgacgca gacctcggcg tcggccatgc gcgccgcgtc gctctcccag
    14761 gcgctgagca tctcgtcgag tagggccggt tcgggacggg ctacggcttg gtgctcgtcg
    14821 ccgatgcgta cggacgtggt ctcgtcgaag gcgagcgggg ccacgccggc gaacaagccg
    14881 aagggggtgg agcggcgggc gtagcggatc gcgtagcggg cggtggccag cgccgcccgg
    14941 cgcatccggc gcgccttcgg cgtgtggccg tcgatgatgg cccgcacctg cgcggcgagg
    15001 tgagggctcg cctgtgccac ggtttggcgg aagtcggtgt cggaccacac cgagttcagc
    15061 cacgcgcgcc actgctccgc gggcgccgcg aattttggcc agggcggcat ggcgggctcg
    15121 gtggtgtgca ccgcggcgcg cagcatggcc tgccccgctc cctcgtacag gctgggccgg
    15181 tgccgtgtca tcagggctct cctcatcttc ctgtgtggcg ggcgggcggg cgggcgggtt
    15241 gggcgtggcg ggccggacgg ggagccccgt ccggcccgcg ttgccggggt gatccggctt
    15301 acgaggtggt gcaggcgctg gggcaggagc tgccgcaggt gtcgcccgtg ctgcacatca
    15361 gggccgtctc ggtcgccggc gtgccctcga tgaaggtgat gtcgagcttg aacgggtcgt
    15421 cgtcggcctt cacgaggtcc gttttcgcgg gaccggtcgg cctttcggcc tggatggcgg
    15481 tcatgcatcc tcctaggagt gagtggtgcg ggatgccgag gtccggtcgg acctcggggt
    15541 ctgctaccag acggtgacca gcggcgaagc cgcctgagcg gtcgctcgcc tggtagtcgg
    15601 tgtggtgccg tcaggtcgca gcggcctgtg cccgcgggtg ctgcttggcg gcctggtcca
    15661 gcacccgggt aaagtgctcg ccctgctcat cgccctcggc ctcctcggcg cggaggtcgc
    15721 cgaaccgctg ccaatagcgt cggcatgcgt cgttctccat cagcttcgcg gcgtgccacg
    15781 gaaggtgtcc ggtgcggacg aagccgaggc ggtcgcggac gctgagaatg cagatgagtc
    15841 ggttggcggc gagcagctgc atgtattcct cgacgtccat gtcctcggga gcccagagct
    15901 tggcgaggtc ggggttggtg gacatctggg ccagccagtc gagctggttg cgggtgagga
    15961 acgcctcgtt gcgctcggcc tggtgccgcg cgttctgcct gagccgggtg gctccgacca
    16021 cggcggtggt gagggagacg gcagcaccgg cagcgaggac ggcggtggtg agcttcatcg
    16081 gtcaacggac ctttcgcaga tcggagatgc ggccagtggg ccgactgagg gaaaacgtgg
    16141 agttccgcct gttcacgcgg cccccgcgag gacgacggtc ggggcttcgt cggcggagct
    16201 gtccggcgtg tagcggcggc gcaccgcctt gagagcgacg gctagtggcg gcagacccac
    16261 ggtggccctg cgtgcgtcga cggacgcagg cgcacgcagc gggcacagct cgatcccctc
    16321 ggcgctcagc atgagctggg tgccgtactc ctgggcacac ccgccggtaa tgagggcacg
    16381 gtcgtgcagg tgcgcccagt gctggacgag cgcgtcgtcg gcctggaccg cacgcccgag
    16441 caggatggtg gcggcgcgct ggagggtgag atcgtggtcg ctgtgcaggg cgatgctcca
    16501 ggcggcgcgg gcagcagcag ggccgacgag gcggtggccg ggccactcgt attcgcccag
    16561 gacgcggcgc aggaacttgg tgttggcgtg gtcggtgtgc cggccctgcc cgagttgcac
    16621 tgcatcgagc tggtcgcgca cgcgtctggc tcggtgcacg gccgattccg ttgcgcgggc
    16681 gatcagctcg cgggcaaggt cgggtcgctg cggttcgtcg gttgtcacgc ggtgctccga
    16741 tcgtccgcgg ccagatgaaa tgcatgggtc tggcagctga tcaatgtgct gagcctgggg
    16801 cggtgctcgg cggtgagttc gaggcgggct acgcggtccc cctcccgtcc cgggccggaa
    16861 ccccgcacgt cccagcccat gtccgtgagc cggcgcagca gggcggcgat gggctcggct
    16921 tggagggcgt ggcgggccag gatttcggcc cgtacgagcg ggaggctctg ccgggcggcg
    16981 aggtcggagg cccacagggt gatcagccgg gtgatgtcgt cgggctgctc gggcagggtg
    17041 tggacgcgtc ccaggcggag acaggggcct tcgccccagc tgaggccggg gtcgcgcgcg
    17101 gggaccatgc aggcgagcag ctttccgtcc tcgaacagac cggccgacgt cgtgtgcggg
    17161 tcgcggaaca gggccggcac gtcggcttgg gcgggcacgg ggaggccgcg cagggtgagc
    17221 cagcgctgcc ggtcctgcac gagagcagcg gcttcctcgc gctcggcgtc cgtacgtaac
    17281 gtgcgcaccg cgtaaacggc gcccgggtac ttcgctgcga acgaggtgga agccggagcc
    17341 tcctcgttgg ccaggggagt gggtggcctt ctcactggcg cgctccgctc cgcgccgacg
    17401 ggtcggtcgg cagcagcttc cagccgtggg caaggatcac caggtgggtg gtgtcccgcg
    17461 cgcctgtgtc ggcgaggagt tggtcgagtg cggcgcgctg gtcggcgggg gcgagcttgg
    17521 cggcgacggc gatgtcacgg gggtcgctgt gctcggcgac ggctcggagc agcagctttt
    17581 gctccgggct gagcgtcggt gccggcctgt cggctgtggg cgggaccacc tgctgggtgg
    17641 tgaacaggcg gtgcacgatc accgggggct tgcagcgggg cgggcagtgc aggctctcgc
    17701 ggatgtcgcg gaggtactgg cggacggtca cgggtgacag gacggtctgg gtggcgatct
    17761 cttgggccgt gaggccgttc gcgaggtgct gggcgacgcg ctgcagggtc ggcgtcaggg
    17821 gtgtgatcgg tgcgctggtc gtcacgggcg gggtcacggt gtctctctcg gctgggtgga
    17881 tggtcacggg gaggggtgcc gccggtcccc gcgggggacg ggggccggcg gcacgggccc
    17941 gtgcgcggcg atggggagtc acggggtgcc gcgcacgggg gctcatgcgg cggtcggatc
    18001 ggggtgcgcc caggcggctt cggcggcgag gcgctcggac cactggatgt ggtcctctgc
    18061 gaaggcggcg tcggccaggc ggatgcgctg gacctcaccg gtcccggccg gtggataggt
    18121 gtgctggatg tcgcgccaca ggcgctggac gatgtagtcg ccatcgaggg cgtgggcgcc
    18181 gtgcagttcc atggcgtcct gggcggactg gacggcccac tggtggccga ggtatttcgc
    18241 gttgatcagt tcggcgtcgc agggcaggcc ctggtcgagg aggtgcacgg actggtaggc
    18301 gagtatccgg gcggcgcgca ggcgggcctc catgccgccg acgcggtccc gcaggacggg
    18361 caagtcggac agggcgccct ggtagcgggg gcgggccttg agccgggcgg tggtggtgtc
    18421 cacgacggct tcgtggatgc cgaggctgac ggcggccagg ttggggcggc cgtagaggat
    18481 gctgctgctc tgggccacgg ccagtccctg gccgatctcc ccgaccacgt tgccggcggg
    18541 gacgcggacg tgatcgaggc cgaggcggcc gacggagaag ccatgcagac cgagccctgc
    18601 acggtggtcg gagacggaaa gcccggggcg gtcggcttcg accatgaacg cggtcagcgc
    18661 ctgcgaggtg ctcacgccgg gcgcggcggt gcgggcgacg acgaggtggg ctccggcgag
    18721 gtggctgttg ccgatatgga tcttgctgcc ggtgatcacc cactcgttgc cggcgcgttc
    18781 ggcggtggtc tcgatgccgc cgatgtgtcc gccggcgagc ggttcggtca cggcgatcga
    18841 cagcaggagg gaaccgtccg ccaccctggg cagccagcgg cccttctgct cgtaggtggc
    18901 gaagtgcagc agggcgccca cagggatcaa tgtggcctgc aggatggccg cggcagccgc
    18961 cgagacccgc gcgatgcggt ggaccaagac ggtcttggcc acgtgtccgg cgcccagccc
    19021 gccgaagacg gccggtacgg tgacggcgaa ccagccccgg gcggccatca ggtcggcgac
    19081 cttgcgctcc acccggcccg gagcggcctc catccgcgcg gcgcgcgacg cgacgtgctc
    19141 ggccgcgaag gcgtccgcct cctcccacag cagatcgtgg cgggcggtga ggtagggacg
    19201 caacgccggt ggaggcgtgg tgggtgtggc ggacatggtc tccctctccc tggatgaagg
    19261 tcgcaacgcg gagcggccgg ggatcgccta cggctcccgg gtggggggtg tggaacgggc
    19321 ttagcggacg agggcccggg acatgtggtc catcacctgc gcgccggtgt tgatggtgat
    19381 gtccctgatc cgtcgggcct cgcgcagagg ccgcttctcg gggtcgatca cacacaccgt
    19441 gcccagcacg gtgccgcttt cgtggatcag cggtgcgccg aagtaggagc ggatcccgac
    19501 ggcgtcgacc actgcgttgc cgctgaagcg cgggctggcg tgtacatcgt gtagcgggag
    19561 ggccttcttg cgggtcatga cctccgggca ccagccgtgg tcgcggctca tggtgcggcc
    19621 gacgatgacg tacccgctgc ccgcgggcgg ctggtgcagc ccgacgaagg tctgcttctc
    19681 caagcccagg ttgacgaagc cgtacaggaa cccggcctgc tcagccatgg cggtggccat
    19741 ctcgtcgaag tcctcgttgg ccacgagggg cacgcccaag cggttgagca gctcgtaacg
    19801 ctgcgccagt tccagcgatt gctgaggccg ctggctggtg agggcggtgc cgggcggggt
    19861 gaacgggccg cggttggtgt cccgcatgtc gcgccgcggc aaggaccctg cgggcggggc
    19921 ggtctgcggc gtgcggtagg gggtgctggg gtgctgtgac atcaggcgtc ctggaggggt
    19981 gtagaggggg cgtgaccagt gcgattggtg gtggcggcgc tgttcacggc gtggtcgacg
    20041 agggccagca gaacgccggc gacgtgattc gtgtcgcggg cgtcgcaggt gaccaccggc
    20101 acggcagcgg ggagttcgag agcggcgcgg acctgctcgg ggtggtagcg gtgcgccccg
    20161 tcgaactgat tgacggcgac gacgaagggc aggccgatgt cctcgaagaa gctgacgggc
    20221 gtgaagctgc tctccaagcg gcgggtgtcg accaggacga ccgcgccgac ggcgccgcgg
    20281 gagaggtcgt accagaggtc gacgaaccgg tcctggcccg gagtgccgaa caggaacagc
    20341 tccagaggaa tcggcgcgtt gggcaggctc agtcggccga agtcgaaggc gaccgtggtg
    20401 gtctgcttcg cctcgatgcc cgccaggctg tcgacgtccg cgctcgcctc ggtcaggtac
    20461 tcctccgtgc tcagcggcgt gatctcgctg acggcgccca cggcggtggt cttgcccgcg
    20521 ccgaaaccgc cggcgatcac gatcttcagc acggtcggcg caccgccccg cgggtgcggc
    20581 gaacgccgcg gcacggcggt tgagtcatcc ggcctgggga taggcgacgg catcaggcca
    20641 cttcctcttc aagccggcgg taacggctgc cagcagttgg gtagacggac cggatcctgc
    20701 gccggtatcg gcataggaat gggtcagggg gacgacgagg gcgtcggcgt ccaggaggtc
    20761 ggagacgagc actttgacgg cgctgacggg ccggccaagg cgtcccgcca gctcgaccac
    20821 cgaccgtcgg cgctcccggc acagggcgag gatttcctcg cactcctcgg cctgcgccgg
    20881 gcctggcctt ccctgcccgg cctccagcac ggtttccaga gcgagcaggt gccgcggcct
    20941 ggtacgcccg cgcaccacgg tgtacgtccg cacgaacgcc gactcctcgg ccgcgcggcc
    21001 gtacgtggtc accggacctc tccgcccgtg ccgacgcgga cggggatcac catgtacggg
    21061 gcgaactttg caacgagccg gcccatctcg aagccgacgg tgcccacgtc ggcgttcctg
    21121 gtggcgatga cggcgaggat cgtgtccacc tcaccgcgtt cgttaccggg gtggttgtcg
    21181 aaggccgcgc tgcacccggc gctctggacg aagaacaggc agtcgtctcg ctcgatgatg
    21241 acctgccggg ccggcctctt cttgtggctc gggccggtga tgttcgccgc gagggaggca
    21301 acgccgctga aggcggccga cagttcgtcc gcccagtcct tgtcgacgtc gctgtccagc
    21361 agccgcagtc cgtcgcgcga gagcaggacg gcgtgcgtga cgccctgcgt ctcggaggcg
    21421 aactgacgca gcagccagac catgctgtcc cgctgtccgc ttggcgtcgt cgcaaatgca
    21481 gcgttgccgt cggtcacgtt tttcatcgcg gggtgggtgc tcatgaggat cgctccagaa
    21541 aggggaaggg ccaatgggtg taccggccac cgggaacgcg gaaggacggg tcagggggtg
    21601 ggctgttctg tccaggcggg agagggactg gcgctgccgc cggcctggag gccgttgcgg
    21661 aaggcggctg cgagcccggg cgtcgccgcg gacacggggg cttgctcacg ctcctgtggt
    21721 ggacggaaag atcccgtccg gcgtgtgcgt gtcggcagag cgggcgcgtc agtcgactga
    21781 cctgcctccg cggtcggtgc ctcgcctacg ccacggcgtg cggcctgtgc tgcctccggc
    21841 acggcgggag tcacggccac ctgttgcggc tgccgcccgg agccgcgagc ttcctcggac
    21901 ggcggcgcgc ccgcatcctc gaccgatgga attgctacca ggagccgtgc cggtatgacg
    21961 accagggcgg tggtgcctcc cgtcgtattc tcctgcagga ggacggtcat cccgtgtgac
    22021 tgggcgatct tcgcggcgac cagcaagccg agctgcccgg cccggacttg gccgctgacg
    22081 tcgacctcgt ccggggcttt gagcaggtgg ttcatctgtg cccgtgtctg tgggtgcatg
    22141 gggatggcgc ggtcctcgac ctcgatggcc agcccgtgtg gcacccgctg cgcgcgcacc
    22201 atcacccgcg tctctggatc cgagcactcg caggcgttct cgatcagctc ggccagcagg
    22261 tgcgtcaggt ccggccccac atggccgggc aaccccagct cggcgcccac ggatccggcc
    22321 gcgacggcca cccgcggata ctgcacgacc tcggagacag cgccacgcag ggccgtcgtg
    22381 acgggaacgg gccggcgcac gctgcgcagg gactgtccgc ctaggaccgc cgtgctctcg
    22441 acctggcggc gcatccgcgt cacgaggtga tcgatctcga agatcttggc cagcagctcc
    22501 gggtcgtcgg tcagcatctc cagctggctc agtgcctgga gtgccttgct gaccagggcg
    22561 tgctcgcgca tggccaggcg gcgaagcact tccaggagga ccacggactg ggactcgtcg
    22621 tgcacgcgga tcagcgacat gatggactgc gcctggaggg cactcagcgc gttgtcgatc
    22681 ccggcgttcg cagtgggcga ctgggcggtg tgcgggtccg gcaacgctgg acgttttccg
    22741 cggcacagct cgtccgccga ccactgcacc gacttctcaa cggctgccgc tgcccctgtg
    22801 accgctgtca gcgctgctga ctgggactcc tccactgccg actgcacggc actggccacg
    22861 gtgcgtgttc cgtgtgtcgc catcgcgacg accgccgcca gtccgcagac catgccggcc
    22921 aggacccagc cggggcctac gacggacccc gaccggagag cgaaggcggc gagcagcagc
    22981 gcggcaagga gtgccagggg cagtgccacg gcgcgacggg cgaggtacag cgtggtcgcg
    23041 tcgaccgggg gccgccgtct gcggtggccg gtagcggccg gccgtgccgg gaaggcgctg
    23101 tcaggcatgg gaatcctcgt caggggtggg gtggctatgc gtgctgcggc gtcaggtctg
    23161 cggtggactg gcgcgtgctg cgggaggctg agcggggcgc tggaaccgcg agcgcgccgt
    23221 ggcgggggga ggactgcgtc gccatctgct gaaggagcag ggcgctttgg atcaggccca
    23281 tgtgactgaa cgcctgcggg aagttgccga gctggcgctg ctggacgggg tcgtactcct
    23341 ccgccaggag cccgaggtcg ttgcgcagag ccaggaggcg ttcgaacaag gcgcatgcct
    23401 cgtcggggcg gccggtcagg gcgaggccgt cgacgagcca gaagttgcac aggaagaagg
    23461 cgccctcgtc gccggtcaag ccgtccaccc cgacctcctc accgcaggtc gggtaccggt
    23521 acacgagccc gtcctccgtt gagagttcac gacggaccgc atccacggtg ccgatgacgc
    23581 gcgggtcatc gggcggcagg aagccggtgc gggggatgag tagtgtggcg gcgtccagtt
    23641 cctgcgagcc gtaggactgg gtgaaggcgt tgcgcaccgg gtcgaagccc ttgtcacaga
    23701 cctcccggtg gatcgccgct cgcagctcga ccagcggggc cacgtcgatg ttgagggcgc
    23761 cagcctcggc caggcggatg gtgcggtcga ccgccaccca ggccatcacc ttggaatgga
    23821 cgaagtgccg gcgggccccg cggatctccc agatgccctc gtcgggctcc cgccagcgct
    23881 ggaccaggtg ctcgatgagc cgctggtgca ggaccgcggt gtcggcgcag tgggcgactc
    23941 cgctccggtg cgcgaggtac agggtgtcga tgacctcgcc gtacacgtcg agctgcagct
    24001 ggtccgcagc cccgttcccg acccgtacgg gggccgagcc ctcgtacccg ggaagccagg
    24061 gaagctcccg ctcccgcagg tcacgttccc cggtgatccc gtacatgatc tgcaggttct
    24121 ccgggtcccc ggccacagcg cgcaggagcc atcgacgcca tgcctgtgcc tcctgccggt
    24181 atccggtccc cagcagcgcg gcaagcgtcg tggcggcgtc gcgcagccag gtgaagcggt
    24241 aatcccagtt ccggtcgccg ccgatctcct cgggaagcga cgtggtcggc gccgcgacga
    24301 tcccgccgct cggcccgtag gtcatggcct tcagtgtgat cgcggaccgg accacggcct
    24361 cgcgataggg cccgtcatag gtgcactcct ggacccagtc ctgccagaaa gcgagcgtct
    24421 gggcgagcgc ggcatgcgcg tcgtgaacgt ccggtgcggc tgcgtgggac gggcaccagc
    24481 tgagcaagaa ggccacgctc tgccccgcgc cgacggtgaa cacgctcacg acgacgccgt
    24541 ccttttccac ctgcgggacg caggtgtcga gccacagagc gtccgcgccg gcctccgcga
    24601 ccatgcgccc accgacctcg tggatccacg ggttgacgct gccgtatccc ggccgaggac
    24661 gcatggccga gaccatctcc acttcgccag tcaggccctc agcgatccgg atcacctgcg
    24721 gggccccgtc gcgcggcggc acgaaatcca ggacccggac cgaaccagtc ggggtacgcc
    24781 acagcgattc gagaacgagc gagtcaccgc ggtaccggcg ctcagccact cttccggagc
    24841 cggaccagcc tgcggacgag gccggggcga tctgccaggt gccgtgcttc tgtgtgccga
    24901 gcagaccggc aaacacggcc ggtgagtcga agcggggcag gcacagccag tcgatcgtgc
    24961 cgtcgtcgca gacgtgggcg ctggtctgcg tgtcgccgat caggccgtac tgctcgatac
    25021 ggggaaggcg tttcatcgtg tgtggatctc cgttaagccc cgctggtctg gggggtgtta
    25081 tcggggccgc tgaagcggcc ggggacaggc cgggagtcaa ggagtcagcg gtcaccgcgg
    25141 ggacgcaggc tcgctcggag gtggtgtaga ggccctgtct gcgggatcga g
//
