LOCUS       NZ_CP036534            32606 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. VN1 chromosome, complete genome.
ACCESSION   NZ_CP036534
VERSION     NZ_CP036534.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. VN1
  ORGANISM  Streptomyces sp. VN1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8341703)
  AUTHORS   Nguyen,H.T., Pokhrel,A.R., Nguyen,C.T., Pham,V.T.T., Dhakal,D.,
            Lim,H.N., Jung,H.J., Kim,T.S., Yamaguchi,T. and Sohng,J.K.
  TITLE     Streptomyces sp. VN1, a producer of diverse metabolites including
            non-natural furan-type anticancer compound
  JOURNAL   Sci Rep 10 (1), 1756 (2020)
   PUBMED   32019976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8341703)
  AUTHORS   Pokhrel,A.R., Nguyen,H.T., Dhakal,D., Nguyen,C.T., Pham,V.T.T. and
            Sohng,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2019) Department of BT-Convergent Pharmaceutical
            Engineering, Institute of Biomolecule Reconstruction, Sunmoon-Ro221,
            Asan, Chungnam 333-708, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: HGAP3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011650445.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 03:53:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,284
            CDSs (total)                      :: 7,197
            Genes (coding)                    :: 7,083
            CDSs (with protein)               :: 7,083
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 44 of 114
            Pseudo Genes (incomplete)         :: 82 of 114
            Pseudo Genes (internal stop)      :: 3 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:32:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3700773
            Orig. end                         :: 3733379
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036534.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jae Kyung Sohng.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..32606
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="14"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..32606
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..32606
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:22606](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..22606
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    1684..1696
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.62"
                     /tool="antismash"
     gene            complement(1864..2430)
                     /locus_tag="EZV63_RS16355"
                     /old_locus_tag="EZV63_16555"
     CDS             complement(1864..2430)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330676.1"
                     /locus_tag="EZV63_RS16355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16555"
                     /product="hypothetical protein"
                     /protein_id="WP_037763432.1"
                     /transl_table=11
                     /translation="MRPLYVPVRLAATAVAVVAAAGCMSVGDESGGAVRPSHSAGERGG
                     AVPEGGATASGGKAGYGPAAADGEHGAGERGKGEGEKEGKGKGEEKGGGGKGKDASSSS
                     PPRSGATPDPPRQGGGGRGDEPGPTRTPPDQPTRTPEPEPEPTEEPPAPPDPDPTVAEP
                     SSSAHEPPQTQLAQREPAPEAGAPV"
     gene            complement(2686..3036)
                     /locus_tag="EZV63_RS16360"
                     /old_locus_tag="EZV63_16565"
     CDS             complement(2686..3036)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566395.1"
                     /locus_tag="EZV63_RS16360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16565"
                     /product="metallopeptidase family protein"
                     /protein_id="WP_031037095.1"
                     /transl_table=11
                     /translation="MLEMTREEFEELVAEALDRIPPELTRLMDNVAVFVEDEPPAEDPE
                     LLGLYEGTPLTERGEWYAGVLPDRITVYRGPTLRFCETREDVVAETEVTVVHEIAHHFG
                     IDDARLHALGYG"
     misc_feature    3098..3117
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 23.79"
                     /tool="antismash"
     gene            3108..4727
                     /locus_tag="EZV63_RS16365"
                     /old_locus_tag="EZV63_16570"
     CDS             3108..4727
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974879.1"
                     /locus_tag="EZV63_RS16365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16570"
                     /product="metallophosphoesterase"
                     /protein_id="WP_166624405.1"
                     /sec_met_domain="Metallophos_2 (E-value: 7.4e-09, bitscore:
                     34.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARVPVAVLHALAEVMNRIRSAPRALARRHRRSHAPAAAPELAAR
                     SHPWTRAVGLVAVVLLGAWLGLLVVGNVRVPVGPMNTTMTLRPSLNGGTKINVSPLGAL
                     RLDSHVAPVRLDVNVDQLDPARAEALVDHPERLSGLQDEVAHDVGHGTLDLAVRSCAAV
                     VTGATALGLVVYRRPRRALGAGGLALTLLLASGGTAYATWNPDSVLEPKFSGLLSSAPS
                     LVGNARSIVTEFDVYQQELARLVTNVTKLYDVTSTLPTYQPDPTTIRVLHVSDIHLNPA
                     SWKIIASLVEQYKVNVIVDSGDTMDHGTAAENGFLDPVEDLGAPYVWVRGNHDSRGTQE
                     YLRHLKNAHVLDDGRARTVAGLRFAGIGDPQYTPDRSKADGAEASQELAGARLASALRD
                     QTAAGTPVDVAVAHEPSAAREVDGAVPLVLSGHLHHEDMEVMKYGTRLRIEGSTGGSGL
                     RAVEGEHPDPIQASVLYFDRDTRRLQAWDQIKLGGLGLTTAEVSRHLPKENQPGATPSP
                     SATSPSPAHSPSTPGTPAPSTP"
     tRNA            4808..4880
                     /anticodon=(pos:3705615..3705617,aa:Glu,seq:ttc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EZV63_RS16370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EZV63_16575"
                     /product="tRNA-Glu"
     gene            4808..4880
                     /locus_tag="EZV63_RS16370"
                     /old_locus_tag="EZV63_16575"
     tRNA            4915..4989
                     /anticodon=(pos:3705723..3705725,aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EZV63_RS16375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EZV63_16580"
                     /product="tRNA-Asp"
     gene            4915..4989
                     /locus_tag="EZV63_RS16375"
                     /old_locus_tag="EZV63_16580"
     tRNA            5014..5090
                     /anticodon=(pos:3705821..3705823,aa:Phe,seq:gaa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EZV63_RS16380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EZV63_16585"
                     /product="tRNA-Phe"
     gene            5014..5090
                     /locus_tag="EZV63_RS16380"
                     /old_locus_tag="EZV63_16585"
     misc_feature    complement(5354..5368)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.66"
                     /tool="antismash"
     misc_feature    complement(5358..5373)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.55"
                     /tool="antismash"
     misc_feature    5413..5426
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    complement(5413..5426)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            5512..6117
                     /locus_tag="EZV63_RS16385"
                     /old_locus_tag="EZV63_16590"
     CDS             5512..6117
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547673.1"
                     /locus_tag="EZV63_RS16385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16590"
                     /product="response regulator transcription factor"
                     /protein_id="WP_031037088.1"
                     /transl_table=11
                     /translation="MASRIVVAGKSLLTAEMMAESLSRAEDLAVVTVVSNFQKLVEVVE
                     RKDADAALIDPERLHGDCMAAACEIRRVRPLCGVALIVDAPTRTFVDQALGAGVLSIIP
                     RSAGLRRLIDSVRGVASGQVVMDPQLLSAAGRQDGPLSDREADVLRLTASGASVKEMSG
                     ELYLSSGTIRNLASGAIKKLGARNRYDAVRIASEQCWI"
     gene            complement(6190..7299)
                     /locus_tag="EZV63_RS16390"
                     /old_locus_tag="EZV63_16595"
     CDS             complement(6190..7299)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547674.1"
                     /locus_tag="EZV63_RS16390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16595"
                     /product="3-dehydroquinate synthase II"
                     /protein_id="WP_070388493.1"
                     /transl_table=11
                     /translation="MTDSRLCWLDVRKTGDLTPAVLEEAVHQRIDAVVTADTAVLAGLP
                     PTVRRVLVHDAGEPADGFDGADLVLVAGGADDRAKLARAYPGVDFGRYVEIVDAETLEQ
                     ACESARTEQWSLLDFRDPTKIPLEIVIAAAAGCDGTIVTMAADVTEAEIVYGVLELGSD
                     GVLMPARTVGDATALRRAAGTTAGEIPLVELEVTATAHIGMGERACVDTCSYLGKDEGI
                     LVGSHSKGMVLCVSETHPLPYMPTRPFRVNAGAIHSYTVSQHGRTNYLSELVAGSKVLA
                     VDTKGRTRVVSVGRVKIETRPLISVDAVAPNGQTVNLILQDDWHVRVLGPGGAVLNSTE
                     LRPGDRILGHLPTADRHVGYPIDEFCREQ"
     gene            complement(7271..8152)
                     /locus_tag="EZV63_RS16395"
                     /old_locus_tag="EZV63_16600"
     CDS             complement(7271..8152)
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036310.1"
                     /locus_tag="EZV63_RS16395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16600"
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="WP_037763440.1"
                     /transl_table=11
                     /translation="MIPQGHFARSLRLRRLHHHTPSGLMVTPLDHSISDGPVVPRNSSI
                     DTLAQQLAAAGVDAIVVHKGSLRHIRPERLAGMSLIVHLNASTGQAPDPDAKYLVTEVE
                     EALRLGADAVSVHVNLGSDDERRQIADLGRVSDACDRWNLPLMAMVYPRGPRIHEPHHP
                     ELVAHAVTIAADLGADLVKTVFPGSLPDLMALTAACPVPVLLAGGPPRATEEGLLGFVS
                     EAVAGGALGVAMGRSIFQSADPQRTAARVARLVHRLPDAPGGASAETVEGADTVGHVTR
                     GHQHDGQQTVLA"
     gene            complement(8149..9708)
                     /locus_tag="EZV63_RS16400"
                     /old_locus_tag="EZV63_16605"
     CDS             complement(8149..9708)
                     /NRPS_PKS="Domain: AMP-binding (24-422). E-value: 1.2e-70.
                     Score: 230.2. Matches aSDomain:
                     nrpspksdomains_EZV63_RS16400_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547676.1"
                     /locus_tag="EZV63_RS16400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16605"
                     /product="fatty acid--CoA ligase family protein"
                     /protein_id="WP_166624406.1"
                     /sec_met_domain="AMP-binding (E-value: 4.9e-67, bitscore:
                     225.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAGQALSENTDQKRNYVLRILEHLGADPARTVVHSWNGDLTAAE
                     FRRCVADAAARLTRAGVGPADTVAVLTEPNSPAMLAARYAAHLLGAAVVHIRSMNARSD
                     EDELPAAEQARLLDATGARVVLADEPNSPRGQELCDGRPGTVLLALSRAAATSGRDPLP
                     AAAPFVAENPAVIDLTSGTTGSPKLVRRSFGVRGQLVDLSFGTRPPEHRPTLLSVTPIS
                     HATATMVDAALAAGGSVVLHNGFDVDDVLRALAERQVTDVYLAVPHLYRLIDQPGLDRA
                     AFPFLRQVLYSGTAAAPARTAEAARIFGETLVQLYGSTEAGGMCTLTPLDHCEPELLPS
                     VGRPFPWVEMEIRHPGSGKPVERGATGEICVRSPTLMDGYLGETDRGCLTKEGDLLRTG
                     DLGHWDKYGYLHLVGRIGSVVKVNGIKVHPTTVQDVLLNHPAVRNSVVYGTRGEEFIER
                     LEAAVQLRPGARCTGDELRSHIAVELSAAHVPDAFDWWEEIPLNPSGKPDYARLRGQKE
                     VQ"
     aSDomain        complement(8443..9636)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS16400_AMP-binding.1"
                     /evalue="1.20E-70"
                     /label="EZV63_RS16400_AMP-binding.1"
                     /locus_tag="EZV63_RS16400"
                     /protein_end="422"
                     /protein_start="24"
                     /score="230.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LGADPARTVVHSWNGDLTAAEFRRCVADAAARLTRAGVGPADTVA
                     VLTEPNSPAMLAARYAAHLLGAAVVHIRSMNARSDEDELPAAEQARLLDATGARVVLAD
                     EPNSPRGQELCDGRPGTVLLALSRAAATSGRDPLPAAAPFVAENPAVIDLTSGTTGSPK
                     LVRRSFGVRGQLVDLSFGTRPPEHRPTLLSVTPISHATATMVDAALAAGGSVVLHNGFD
                     VDDVLRALAERQVTDVYLAVPHLYRLIDQPGLDRAAFPFLRQVLYSGTAAAPARTAEAA
                     RIFGETLVQLYGSTEAGGMCTLTPLDHCEPELLPSVGRPFPWVEMEIRHPGSGKPVERG
                     ATGEICVRSPTLMDGYLGETDRGCLTKEGDLLRTGDLGHWDKYGYLHLVGRIGSVVKV"
     CDS_motif       complement(8557..8619)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS16400_0001"
                     /evalue="9.00E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="EZV63_RS16400"
                     /protein_end="384"
                     /protein_start="363"
                     /score="18.1"
                     /tool="antismash"
                     /translation="GATGEICVRSPTLMDGYLGET"
     misc_feature    complement(9733..9747)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.88"
                     /tool="antismash"
     misc_feature    complement(9762..9775)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.6"
                     /tool="antismash"
     misc_feature    9812..9827
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            10001..11542
                     /locus_tag="EZV63_RS16405"
                     /old_locus_tag="EZV63_16610"
     CDS             10001..11542
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: goadsporin_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547677.1"
                     /locus_tag="EZV63_RS16405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16610"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_166624407.1"
                     /sec_met_domain="goadsporin_like (E-value: 1.3e-176,
                     bitscore: 586.8, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PF00881 (E-value: 1.1e-13, bitscore: 50.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPGTPWPEAWPEVECAEYSVGFRDDVRVGFDAASVSLTTPASTF
                     AVRMPEGPTRDALASLAGGHVPLGELLDGFEPAERSRFQGLLGRLGRLVEYGVAVGGRD
                     LIRLQQTGLEADPVAGTVRPDDVVRLSRFALCRSRSGVLALESPLATARALLDHRAARV
                     LVSSLAAEQRVGDLAEQVAADAALPDTCALLGVLAGAGLVDVRRADGAFDEEGPALRQW
                     EFHDLLFHSRIRSGRHDAPLGGTFPHRGRLAPQPAVKPVPDGPAIELYRPSLEAITERD
                     PGLTAALEGRRSFRSYGDRPLTAEQIGEFLYRVGRVRTLFVPAAGDEPGGEIVSRPYPT
                     GGSSYELELYLTVQRCAGVEPGIYYYDPVAHRLVLVNDAYRDRRAMLEAASVATAREAD
                     PDLLITMTSRFQRLSWKYSGMAYATTLRHTGVLYQTMYLVATAMGLAPCGLGIGNADMS
                     ARVLGLDYLRESSVGDFILGSRPPGDPGIWDPAQGWEWVNDPQWAAWAGTELGRT"
     misc_feature    complement(11616..11633)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    complement(11670..11685)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            11780..11956
                     /locus_tag="EZV63_RS16410"
                     /old_locus_tag="EZV63_16615"
     CDS             11780..11956
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547678.1"
                     /locus_tag="EZV63_RS16410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16615"
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_078535764.1"
                     /transl_table=11
                     /translation="MSTVAIDSADIEQVFDSFDVTELEVLEVSQGVALPEMGASGGTVG
                     TSSSSSTCSSSTC"
     misc_feature    complement(11811..11826)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.12"
                     /tool="antismash"
     misc_feature    complement(11822..11835)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.36"
                     /tool="antismash"
     gene            complement(12056..12556)
                     /locus_tag="EZV63_RS16415"
                     /old_locus_tag="EZV63_16620"
     CDS             complement(12056..12556)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EZV63_RS16415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EZV63_16620"
                     /product="hypothetical protein"
                     /protein_id="WP_224220162.1"
                     /transl_table=11
                     /translation="MSVFASMWEGLGVAGIGPRVPSPVLSGIAALAVVVAVTAVVLTVR
                     LGRLPGPRRVRRVAVNSFQVFGRVNIGQTVAIVAAVLLLGRFEQWEYVPAVVCLVVGAH
                     FLPLARTFAQPQYWWTGGLLMALALVGAVALGGGDGSNGRVLLGFGAALVLWTTALHVA
                     RKG"
     misc_feature    complement(12724..12738)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.65"
                     /tool="antismash"
     misc_feature    complement(12725..12738)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.63"
                     /tool="antismash"
     gene            12747..13907
                     /locus_tag="EZV63_RS16420"
                     /old_locus_tag="EZV63_16625"
     CDS             12747..13907
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036317.1"
                     /locus_tag="EZV63_RS16420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16625"
                     /product="hypothetical protein"
                     /protein_id="WP_224228294.1"
                     /transl_table=11
                     /translation="MRANAPEDRIDAPASGRLTGVRLFTRAPVTLAWLAASAVPVARSV
                     RENGGAVVRLRRGWLHGPHVDVVGRGALGQELPWRSLARRLDAGPLPADRALDEEKYLA
                     QAREFGRLEAVAPPYLPMREHGEVEFLGPDDGEVRDPLLRDLREAEIVHGVLCPPLMNT
                     IEELAKDPSLATARLAEAFLALGDSYFLGLAHGAFSFRSHSEAFLAWAAPSKDMRPVFA
                     ARRAKEAPVLRELVEQRLAGRVGPAAAEWRTAFAYSTGALDSAVVDGRLTPAVLDAVNS
                     AVDTTAMGPPAAPDAVPRGEHPDTEFHRATAESGVIDDPTPWFAAYRLLINLFYQQLPL
                     LTVSPIQRYYMCYALAETIDEVLGETWQERLAKGRARWERTRRTTR"
     gene            13904..16519
                     /locus_tag="EZV63_RS16425"
                     /old_locus_tag="EZV63_16630"
     CDS             13904..16519
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906220.1"
                     /locus_tag="EZV63_RS16425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16630"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_166624408.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.9e-14, bitscore:
                     51.4, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALETCTAGAPQSVSGSPQKEPLWLLRINPLSRVRLADEGLRGL
                     LARLEQAERDVRSAADRCSDELYGLIGETTDDTARGRLIAARRAVHNDRPLRNAPPSVL
                     GVPSVSEWLRATDERRRLREETARHYEQAADRERHRLAGVLADEHLRSSLALVSPEVYQ
                     ESERYRAAVAGPGRLSARSRKSERGLLQYVTRAMVRTSPLARFTAVGLAVPAPGGIDPG
                     AVGFGTAAAFPGLDRVMVGYVLGGLPAATGSALLDAWVSLSPTSALDESRETLYFLRPS
                     ESGFQRLSAPVKGVVRALVDATVMGPRPVRSVVSHLAEQTGCTAQDAAKAVLQGVHQGI
                     LCTYNEPEDGAADLAQLLSRPGAPGSELLDGVRCRLSRLATGPVDERRHELGAIEADFA
                     QLVRLAGRPARVTVEEDYVLAPTTVDSGRWRRPLADLGPTVELLSVFDWLHDVRILTTA
                     AFVQRFGAGANVPLARHAESLVKEVSRRAALMGQSYESGDTGALDGLGTPDGSLERLFA
                     LRHRITEETRSRITRAVDTGAADVRLTAEEASELAGGMPERVRRDPMSYGVMVQAAGRH
                     LVFNDGLPGHGMLYSRFLDADRSLSGEAIPYLAERLTERYAWDGARVVEERGLHRLNVN
                     AHPHVLPAGMEPDDWFALRLVHDTEQDTLCLEDGEGRRTRVLPLGTGHPGLFPPPLSLA
                     TSLTTGGRLNNDLLDGWFGARPRDDGQRTLVCPRFSVGDVLLSRRRWYGGAELTAALGA
                     GPAEQDRLLALTAWRARHGVPEEVVLKTAFGADAPRTLNPADVLPRRLRHKPQYVDLVS
                     ALSTRVLPKMLERRATAHESVDYLEEALPSVVEGTHAQEWVVEIGRRPGGAFQYEGENG
                     "
     aSDomain        16522..16761
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EZV63_RS16430_Thiopeptide_F_RRE.1"
                     /evalue="9.40E-11"
                     /identifier="RREFam004.1"
                     /label="EZV63_RS16430"
                     /locus_tag="EZV63_RS16430"
                     /protein_end="80"
                     /protein_start="0"
                     /score="32.6"
                     /tool="antismash"
                     /translation="MRARPYLHCAPVPGGVYFSGARTQFVLKGWDQLFKVADVCVPLLE
                     RGTTEDDLVAALGTERARPVVRRLTGGLREHGMLL"
     gene            16522..18195
                     /locus_tag="EZV63_RS16430"
                     /old_locus_tag="EZV63_16635"
     CDS             16522..18195
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547682.1"
                     /locus_tag="EZV63_RS16430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16635"
                     /product="hypothetical protein"
                     /protein_id="WP_224220159.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 2.4e-08,
                     bitscore: 32.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRARPYLHCAPVPGGVYFSGARTQFVLKGWDQLFKVADVCVPLLE
                     RGTTEDDLVAALGTERARPVVRRLTGGLREHGMLLDEDVLRGDRTSVADRERYAGTLAY
                     LESVSADPYAAFAAVRAARVVLSGPADAVRPAARGLSRAGVGRVLVQDTAGPEACEGAD
                     AVLWCGRDEDGPGEYAGRVPGGVPVVPVLLGDRVLQAGPVVHDAAQYARLAAFRRRVLG
                     WAQGEELGPAARPVADAMTGAIAGQLVLDVLAGLDEGRTAHVVHGADLVAERVLLPAAA
                     PVGGPRTLAAAPAAPLPDPDETIEQVNTLTARWKGLFTAARAEQDLPQMPLAVRATEPR
                     TGTTGRTAVWGPDQRAATVGAALQVLRGSVPQAEGAVGAAGVTEERWLLDGVLRLLADE
                     AEADHTVVDENEETARIRRILQEWQRDRLTTRVFRVPGLDWRLARVGPTAGGTPLGASW
                     AFDADSAVRQALSTALARAQVEAAHAGGADVPPLVTDSAGAADEERIGSLREQVLRLGA
                     ARGVSYEGTSLRSDPVLGEIPFWFGPVHARQLTQEPRHAR"
     gene            18185..20134
                     /locus_tag="EZV63_RS16435"
                     /old_locus_tag="EZV63_16640"
     CDS             18185..20134
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547683.1"
                     /locus_tag="EZV63_RS16435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16640"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_031037058.1"
                     /sec_met_domain="YcaO (E-value: 4e-65, bitscore: 219.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDEQHHGPGLGGSDGLWDEALRGLGDALDAKVVANRGWDLSWER
                     LQWEKASADGEDLVSVRVYDDEVVVGPRWVPGTDSGCASCAEVRERTTAEHPLATALDT
                     PRAVPRAARPLLPLLLAAAAANLADHPLGPGELYAVGAQYVRRHRVPRSFFCPACADHG
                     SVAADDWRPEPLELPAEPLSSKDPTRGAGGAHLVEPGALRERLLDARYGPIQVIMRESD
                     VPFAMSMCLAPDAAAPGHGRAGTFAEADPVGIIETYERLGSFPFDTPLLLERSHREVAA
                     HALDPVTLGEHTEKQLEHPDCQVLPYTPDTPMDWVWGHDLATGEPLLVPAEAGFYQYEQ
                     RFKLSRHAARAARVEARRARAAGHRPAPGTLRKYFHDSSSGCAAGSSLTEAALHSLLEL
                     AERDAFLLSWHRREPLPRIADASITDPESRSLIDLIRTRGFDVHVLVARQDIDLPIVWV
                     LVVNRQNPFPASYSSGGSGADPDTAIRGALREVAQLVTNKMQWNREEAEQMLDDPWKLV
                     ELEQHPQLYTLPEKLARVTEVLGGPQTTVQDAFPGWPQVLRRASGGTVRGALDHVRALY
                     AAAGLDRIVLVNQTTREHADAGISVAKAVVPGILPMCFGHAQQRLKNLPRLVAALAGTP
                     QENREIPYDPHPFP"
     gene            20112..21668
                     /locus_tag="EZV63_RS16440"
                     /old_locus_tag="EZV63_16645"
     CDS             20112..21668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010035545.1"
                     /locus_tag="EZV63_RS16440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16645"
                     /product="hypothetical protein"
                     /protein_id="WP_166624409.1"
                     /transl_table=11
                     /translation="MTHTRSHEPAQVRRAPVDLPAPYGDNNIEREPLWYAFGAGSDEPA
                     VPPWTRVDQPPMTAHTHPPPPSCARGGSCVELPRETHELLDRTPYPHGRAAVRDPDEAL
                     LRALVAGFGVQWSDPDAVYDPHRGYASPRCLYPVQVFVDDGQHWHLLDPERHTLTVLTA
                     GTHRGRQRRIALTGRYTRIPSGYKWFRGSLVNLELGIVLRQLALALELFGLSGRVVLPH
                     GGSAALLDELGLTPGWEWSLPTVVEIGPESREPAPAADAPKPEDQPGNQPEDQPEEPAL
                     RDLVRVNRTQDFTDAPAPLPSAVPARPVPGPGTASWADLMWRRNSGRMPRGLLGMSGRR
                     TRVPAGSVEDALRWLDAPPPGPTLAAVADLVTLTVVTQDVAGLPDGIHRVRAGECVQLS
                     ADRTAAARLEAEYGYGLSTDAGCDIRNASAIWFMSVKPRELFARLGANGWSAAQYWCGW
                     ALHGLCLSTTAYGMFTRPVRAFNEIPVQRILRLGPDEMLALAAVVGTPRYPAHGLLDIR
                     V"
     gene            21683..22606
                     /locus_tag="EZV63_RS16445"
                     /old_locus_tag="EZV63_16650"
     CDS             21683..22606
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906224.1"
                     /locus_tag="EZV63_RS16445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16650"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_051159549.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-36, bitscore:
                     125.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQQTAPGTPTPDTGTTWSAWHLHVASNAPSLLDRVVNRVVAPVT
                     RTLDGAPWFFIRYWEGGPHLRLRVGDLGHAEHARVEALLRDLLAAEGRPAGDEQPFGEE
                     AYRAAAGQLARAEYGGDHPVAELRPPGVHRALYEPETARYGGAALMPRTERLFQRSSEL
                     VLALLPHVSTPQTRSALALRATVSAAAALGDDAEQALYYAHSLAAWRAWAAGLGSTPGE
                     LDRLCHIPEGSARPVDPDRHGPFEPWHAALTELVREVRATTDSVPGQIVVSHVHMFHNR
                     LGRTLFDELRTYAWLERAFPARGVRT"
     gene            22603..23856
                     /locus_tag="EZV63_RS16450"
                     /old_locus_tag="EZV63_16655"
     CDS             22603..23856
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906225.1"
                     /locus_tag="EZV63_RS16450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16655"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_166624410.1"
                     /transl_table=11
                     /translation="MTRRPRIAVVGAGIGGLTLARALAESGTPCEVFEQARAMTEIGAG
                     VQLAPNTVRSLRSLGLEAALARHAVPVEAMRMYGWRGGPITATPFGAACETLYGAPYCA
                     VHRADLQGALLTLVGPGPLRLGHRLRDLSPDGDEMVLTFDNGRTHRADLVVGADGIHSV
                     VRERLVRDAPVFSGLGVFRGLVPVDRLPTAARQPLIRMWLGPGRHFVCYPVSGGRLLSF
                     AAISPLATAGAESWSAEGDATALTEDFDGWSGLVPAVTRAVGTVRRWALHDRPVLHTWA
                     TDRLAVLGDAAHPMLPFMAQGANQAVEDAVELASLLAGASADEIPERLRAYELVRAPRA
                     AAVQQGSRGHSETMHLPDGPRQRERDQALRRTGGLTGLRERAWLYGHEAGTRRTPPTAA
                     NSAGTAKEEEEEGRGPAS"
     gene            23853..25043
                     /locus_tag="EZV63_RS16455"
                     /old_locus_tag="EZV63_16660"
     CDS             23853..25043
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906226.1"
                     /locus_tag="EZV63_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16660"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_037763449.1"
                     /transl_table=11
                     /translation="MKDTGLRVAVVGAGVSGLALAILLRRRGVHCDVYEKSAALGAVGA
                     GIQLTPNGARVLGELGAEEPLRRRGITANAIESRRWSDGAMLSRVPFGDACVDRFGAPY
                     HLVHRADLQACLMDLLPPGGLYLGRTVDGVTDHGDRADLRFTDGTTVTADVVIGADGVH
                     SAVRGAVLDDRPVYCGYSVYRGLVPAGAVPSFTGDPRVMFWFGPGRHVTCYPVSSGRTV
                     HFSAVCADPYAGTGPRSAVAGAGELMAEFGGWHEDVRRVLRAADSVTRWGLFDRDLPGR
                     YVTGRVALAGDAAHPLLPFLSQGAGQALEDAVVLADVLTAHGDDVPGALRAYEAVRMPR
                     TAEVHRQSRLRAGTFHLPDGPEQTARDTQWARTQDLCHLDWLYGATVRPAPALTRS"
     gene            complement(25100..25924)
                     /locus_tag="EZV63_RS16460"
                     /old_locus_tag="EZV63_16665"
     CDS             complement(25100..25924)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467317.1"
                     /locus_tag="EZV63_RS16460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16665"
                     /product="ABC transporter permease"
                     /protein_id="WP_166624411.1"
                     /transl_table=11
                     /translation="MTVSSPAPAAATAPDAAPGTAVGRGRLRLVAHQIRYEQLSFWRNP
                     QAVIFTFLLPVLVVTVFGAVFGGDQKSDFYFGLSGMQYYTPTIAAVSVLGACYGQLAIV
                     LSTRRQTGMLKRLRATPLPAWIYFTGLLAHCLLVGAIDIGLVIGVGTLYGVPLPAHWAG
                     LALALVLGAASFCALGAGVASLVRSAESAPALVQFIQFPLVFISGSYFPVHADALNTIA
                     GLLPVKPFNEALLAAFTGASGHGWRGLGVLAAWGVLGAVVAVRRFRWDPRPE"
     gene            complement(25921..26904)
                     /locus_tag="EZV63_RS16465"
                     /old_locus_tag="EZV63_16670"
     CDS             complement(25921..26904)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547689.1"
                     /locus_tag="EZV63_RS16465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16670"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_037763455.1"
                     /transl_table=11
                     /translation="MTAVVVEGLRKAYGSRDVLLGIDFAVTEGEIFALLGPNGAGKTTT
                     LEILEGFRGRDEGRVEVLGMDPRSSAVAHELRERVGIVLQDTAVEPYLSVRETIARDAG
                     YYRAPRDVDGVIELVGLREKRRAKVKDLSGGQKRRLDLALGVVGNPSLLFLDEPTTGFD
                     PSARRSAWELVRDLRDSGTTIVLTTHYMDEVQALADSVTVIADGRIVDSGTPATLGGRD
                     KAFARIRFELPPGTGVLDLPLPTAPPVVDGMVHLEVREPTAVLHSLTGWALERGTTLGR
                     LTVERPSLEDVYLEITRSFETGEAAQSQQPQQSAAVRGRRRKRSRT"
     gene            27149..31102
                     /gene="hrpA"
                     /locus_tag="EZV63_RS16470"
                     /old_locus_tag="EZV63_16675"
     CDS             27149..31102
                     /EC_number="3.6.4.13"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003724 - RNA helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="hrpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451328.1"
                     /locus_tag="EZV63_RS16470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16675"
                     /product="ATP-dependent RNA helicase HrpA"
                     /protein_id="WP_166624412.1"
                     /transl_table=11
                     /translation="MSTHPAPALGTLAPRLTELSLRDAHRLGRRLEGARKIRKPEARAT
                     VLAEIEAEVAKAEQRIGERRARVPDVSYPAQLPVSQKKDEIAAAIRDHQVVIVAGETGS
                     GKTTQIPKICVELGRGVRGMIGHTQPRRIAARTVAERVADELDTPLGETVGWKVRFTDQ
                     VNPESTFIKLMTDGILLAEIQTDRELRAYDTIIIDEAHERSLNIDFLLGYLAQLLPKRP
                     DLKVVITSATIDPERFSRHFGDAPIVEVSGRTYPVEVRYRPLLEEDGDDADRDQITAIT
                     DAVEELMGEGNGDILVFLSGEREIRDTADALEKKKYRGTEVLPLYARLSHAEQHRVFQR
                     HSGRRIVLATNVAETSLTVPGIKYVIDPGFARISRYSHRTKVQRLPIEPVSQASANQRK
                     GRCGRTSDGICVRLYSEDDFDARPEFTDAEILRTNLASVILQMTAAGLGDIEKFPFIDP
                     PDHRNIRDGVQLLQELGALDPAQKDVRKRLTDTGRKLAQLPVDPRLARMVLEADRNGCA
                     REVMVIAAALSIQDPRERPAEKQAQADQQHARFKDETSDFLAFLNLWRYLREQQKERGS
                     SSFRRMCKQEYLNFLRIREWQDIYTQLRTVAKQMGIRLNDDDAPGDRVHVSLLAGLLSH
                     VGMKDVKEGAKNEYLGARNAKFAIFPGSALFKKPPRFVMSAELVETSRLWARVNAKIEP
                     EWVEPLAGHLLKHTYSEPHWEKDQAAVMAYEKVTLYGVPIVAQRKVNYGRIDPEVSREL
                     FIRNALVEGDWRTHHKFFADNRRLLTEVEELEHRARRRDILVDDETLYDFYDQRVPEHV
                     VSGAHFDSWWKHKRHDRPDFLDFEREMLINEKAGAVTKDDYPDTWRQGPLKFRVTYQFE
                     PGADADGVTVHVPLQVLNQVADEGFDWQIPGLREQVVTELIRSLPKPIRRHYVPAPNYA
                     QAFLDRAVPLQEPLAVTMARELKRRVGVPLEAEDFDWAKVPDHLKITFRIVDERRRKLA
                     EDKDLEALKLQLRPKARKALSQAAAATAVRSGGESLERTGLTDWTIGTLSRVFETRRAG
                     QPVKAYPALVDDGPKANTVSVRLFDTEAEQAQAMWKGTRRLILRNIPVNPAKFASEKLT
                     NQQKLGLSANPHGSIQALFDDCATAAADKLVADFGGPAWDEESYRKLYDKVRAEIVDTT
                     VRTVGQVQQVLAAWQACERRLKAVRSPALLANLADVRAQLDALVKPGFVTEAGIRRLPD
                     LLRYLVAADRRLQQMPTGVPRDTSRMEKVHEMRDEYAWLLEQMPRGRPVPQQVLDVRWM
                     IEELRVSYFAHALGTAYPVSDKRIVKAIDALAP"
     tRNA            31196..31270
                     /anticodon=(pos:3732004..3732006,aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EZV63_RS16475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EZV63_16680"
                     /product="tRNA-Asp"
     gene            31196..31270
                     /locus_tag="EZV63_RS16475"
                     /old_locus_tag="EZV63_16680"
     gene            31614..31823
                     /locus_tag="EZV63_RS36935"
                     /old_locus_tag="EZV63_16685"
     CDS             31614..31823
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330672.1"
                     /locus_tag="EZV63_RS36935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16685"
                     /product="DUF6274 family protein"
                     /protein_id="WP_078535765.1"
                     /transl_table=11
                     /translation="MAASVRHETRALLRAHLSAASSYGHATRHCPICHRLLRLALDAPA
                     PRLPVAQLPTGRQEGVEDGSTPTA"
     misc_feature    31770..31772
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(32274..32480)
                     /gene="bldC"
                     /locus_tag="EZV63_RS16485"
                     /old_locus_tag="EZV63_16690"
     CDS             complement(32274..32480)
                     /codon_start=1
                     /gene="bldC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949541.1"
                     /locus_tag="EZV63_RS16485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_16690"
                     /product="developmental transcriptional regulator BldC"
                     /protein_id="WP_003949541.1"
                     /transl_table=11
                     /translation="MTARTPDAEPLLTPAEVATMFRVDPKTVTRWAKAGKLTSIRTLGG
                     HRRYREAEVRALLAGIPQQRSEA"
     misc_feature    32516..32530
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.76"
                     /tool="antismash"
ORIGIN
        1 gagagcgctc accccggtcg gcgaagcgat cgcggccgtt gccgccgcgc tccgtccggt
       61 ccgcccgctc cgtccggtcc gccttctccg cgtcccgggc gccggactgc tccggcagcg
      121 agacctcggc cgccgccacg gccgcggccg cctcggccac cgccgtctcg gggtcgtcgc
      181 cccgctcgcg cgccgccctg gcgaccagcc ggtccgcctc ctcgcgcagc tcggtggcgc
      241 gccgctgggc ccgctccagc tccttggtga gctgggtgac gtcccgctcg gcctgctgcg
      301 ccgcgttgcc cgcggactcg gcctggacct cggtcatcga ccgggcgccg gtgatctcgg
      361 cgacctccgg ttcgaaggcc gcgccgccct ggatgatgtg gcgcgtggca tcgacgcccg
      421 cgtcctccat cagccggaag atctggcggc gctggtgcgg cagggagagg gagaccacgg
      481 tgccggtgcg gccggcgcgc gccgtgcggc ccgcgcggtg caggtagtcc ttgtggtcgc
      541 cggccgggtc cacgttcagg accaggtcga tgccgtcgac gtggatgccg cgcgcggcga
      601 cgtcggtggc gaccaggacg ttgacgtaac cgtccttgaa gtcggccagc gtgcgggtgc
      661 gcgcgccctg ggtcatgccg ccgtgcagcg cgtccgcctt cgcgccggcg tcgcgcagct
      721 gctcggcgac gcggtcggcg cccagctggg tgcggacgaa gatgatggtg cggcccttgc
      781 gggaggcgat ggccgcggtg accggcgcct tgtccttggg cttcacgacc aggatgtggt
      841 gcgacatggt cgtcaccgcg ccctgggccg cgtcgacctc gtggctgacc gggtccttca
      901 ggtaccggtc gacgagggtc ttgatctcgt tctccatcgt ggcggagaac agcatccgct
      961 ggccgcccgc ggggacctgg tcgagcagct cggtgacctc gggcatgaag cccaggtcgg
     1021 acatctggtc ggcctcgtcg aggaccgcga tctccacgtt cgccagggag caggcgccgc
     1081 ggttgatgat gtcgcgcagg cggcccgggg tggcgaccag gatgtcgacg cccttctcca
     1141 gggcgtagat ctggttgccc atggaggtgc cgccgcagac gaccttcatc cgcaggccca
     1201 tgacgtcgcc gtacggctgg agcgcgtcgg cgacctgcat ggccagctcg cgggtcgggg
     1261 tgaggatgac ggcacgcggc ttgtgcttct cggtgcggcc gccggccagc gtggccaggg
     1321 tcggcagacc gaaggagagg gtcttgccgg agccggtgcg gccccggccg aggatgtcct
     1381 tgcccgccag cgcgtccgga atggtcgcgg cctggatggg gaagggggtg gtcacgccgt
     1441 tctgcgcgag cttgcgcacg acgccctcgg ggagaccgag gtcggcgaac gtcggctcgg
     1501 gagcctcggc ggccgcgggg gcctcggtgg tctcagcggt cacggggggc tcgacggcct
     1561 ccggtgcgcc ctccacgcct tcggcgttct cgggcacgac gacgtgatcg gtactggtca
     1621 tggacatgcg aatgcgaaac cttccggagt ctctcgtcgg cacgcgcccg tcaactccgt
     1681 gaatcgcgat tcgcaatacg accgcctcaa tgcggtccac cacggcaagg ggagagtacg
     1741 cgccacacgg cgcgctctgc ggtggcgccg ggcaaatggg atcaaacgat ctaccaccat
     1801 acgcacctcc cacccccgaa ggcaaaccga gcggctcgcg acgggtccgg aaggcgcgtc
     1861 tccctacacg ggagcccccg cctccggggc cggctcgcgc tgcgccagct gggtctgggg
     1921 cggctcgtgc gccgacgacg acggctccgc gaccgtcgga tccgggtccg ggggcgcggg
     1981 cggctcctcg gtcggttccg gctccggttc cggcgtccgg gtgggctggt cggggggcgt
     2041 ccgggtgggc ccgggctcgt cgccgcggcc cccgccgccc tgcctcggcg ggtccggggt
     2101 cgcaccggag cgcggcggag acgaggagga cgcgtccttc cccttgccgc ccccgccctt
     2161 ctcctcgccc ttgcccttgc cctccttctc gccctccccc ttgccgcgct ccccggcgcc
     2221 gtgctccccg tcggccgccg ccggaccgta cccggctttg ccgcccgacg cggtggcacc
     2281 gccctcgggc accgcaccgc cccgctcacc ggcggagtgc gacggcctga cggcccctcc
     2341 ggactcgtcg ccgacactca tgcagccggc cgcggcgacg acggccacgg ccgtggcggc
     2401 cagacggacg ggtacgtaca aggggcgcac gggcggccac ctccgggggt caggatgtcg
     2461 ccgtgcccaa ctcccgtcac ccacaagagg acacgcgccc ggcggggcag acttgacccg
     2521 agcgcgtcac cgagtccgcg cgtcgggaag cgcgcgagcc cgcgtcaccc gcagccgcaa
     2581 gcccgtaacc gagagcccac agccgggagc ccgttgccga gagccccgcc tccgcggccc
     2641 gcagccggaa gcccgcgtcg ggaagccccg cgcccggaag ccccgtcacc cgtacccgag
     2701 ggcgtgcagc cgcgcgtcgt cgatgccgaa gtggtgggcg atctcgtgga ccaccgtcac
     2761 ctcggtctcc gccaccacgt cctcacgcgt ctcgcagaac cgcagcgtcg gcccccggta
     2821 gacggtgatc cggtccggca gcacgcccgc gtaccactcc ccgcgctccg tcagcggcgt
     2881 cccctcgtag aggccgagca actcgggatc ctccgccggc ggttcgtcct cgacgaacac
     2941 cgcgacgttg tccatcagcc gcgtcagctc cggcgggatc cggtccaggg cctcggcgac
     3001 cagttcctcg aactcctcgc gcgtcatctc cagcaccgct ccattgtcgg gtacgaccgt
     3061 gcggtacgac ccgcatatcc gccccgggcc atgggcatac gggaccaatg gcccgcgtcc
     3121 ccgtcgctgt cctgcacgcc ctggccgagg tgatgaaccg catccgcagc gccccgcgcg
     3181 cccttgcccg ccgccaccgc cgctcccacg cccccgccgc cgcacccgaa ctcgccgccc
     3241 ggtcgcaccc ctggacccgc gccgtgggcc tcgtcgccgt cgtcctgctc ggcgcctggc
     3301 tgggcctgct ggtcgtcggc aacgtccggg tcccggtcgg acccatgaac accaccatga
     3361 ccctgcgtcc ctccctcaac ggcggcacga agatcaacgt ctccccgctc ggcgccctcc
     3421 ggctcgacag ccacgtcgcc ccggtccgcc tcgacgtcaa cgtcgaccaa ctcgaccccg
     3481 cccgcgccga ggccctcgtc gaccaccccg aacgcctctc cggcctccag gacgaggtcg
     3541 cccacgacgt cggacacggg acgctcgacc tcgccgtccg ctcctgcgcg gccgtcgtca
     3601 ccggcgccac cgcgctcggc ctcgtcgtct accggcgccc ccgccgcgcg ctgggggccg
     3661 gcgggctggc gctcaccctg ctgctcgcct ccggcggcac ggcgtacgcc acctggaacc
     3721 ccgactcggt cctggagccg aagttctccg gcctgctctc ctccgcgccc tccctcgtcg
     3781 gcaacgcgcg cagcatcgtc acggagttcg acgtctacca gcaggaactg gcccgcctgg
     3841 tcaccaacgt gaccaagctg tacgacgtca cctccacgct ccccacctac cagcccgacc
     3901 cgaccacgat ccgcgtcctg cacgtctcgg acatccacct caacccggcg agctggaaga
     3961 tcatcgcctc gctggtggag cagtacaagg tgaacgtgat cgtcgactcc ggcgacacca
     4021 tggaccacgg cacggccgcg gagaacggtt tccttgaccc ggtcgaggac ctcggcgccc
     4081 cctacgtctg ggtccgcggc aaccacgact cccgcggcac ccaggagtac ctgcggcacc
     4141 tgaagaacgc gcacgtcctg gacgacggcc gggccaggac cgtcgcgggc ctgcgcttcg
     4201 caggcatcgg cgacccccag tacacccccg accgctccaa ggccgacggc gccgaggcgt
     4261 cccaggaact cgccggcgcc cgcctggcct cggccctgcg cgaccagacc gccgcgggca
     4321 cccccgtgga cgtcgccgtc gcccacgagc cgtcggccgc ccgggaggtc gacggcgcgg
     4381 tgcccctcgt cctctcgggc cacctccacc acgaggacat ggaggtcatg aagtacggca
     4441 cccggctgcg gatcgagggc tccaccggcg gcagcggact gcgggcggtc gagggcgagc
     4501 accccgaccc gatccaggcc tccgtcctct acttcgaccg ggacacccgg cgcctgcagg
     4561 cctgggacca gatcaagctg ggcggcctgg gtctgacgac ggccgaggtc agccgccacc
     4621 tcccgaagga gaaccagccg ggcgcgaccc cgtccccctc cgccacgtcc ccctcccccg
     4681 cccattcgcc ctccacccct ggcacccccg ccccgagcac tccgtaaacc gttttggcga
     4741 tacctcccgc catcccatat gcttctcacg tccccgacgc gctgcgaagc gcccaggcgg
     4801 gccgatagcc ctcatcgtct agcggcctag gacgccgccc tttcaaggcg gtagcacggg
     4861 ttcgaatccc gttgggggca cgcagtacgt gtgcgacact gtcgtacgca gcttggtcct
     4921 gtggagcagt ttggagtgct cgccaccctg tcaaggtgga ggccgcgggt tcaaatcccg
     4981 tcaggaccgc tgaggtttca cgtgaaacct cgcggctggg tagctcagtt ggtacgagcg
     5041 atcgcctgaa aagcgatagg tcgccggttc gaccccggcc ccagccacca gtagaaagac
     5101 gtcccggacg gcatgccgtc cgggacgttc gcgttgcatg ccccggtcag aggtcccggc
     5161 aaggcacacc cctggcggcg gcacttccca ggcactcatc acccctcccc tcaccggctg
     5221 gcccgtacgg tacgaaccgc cgcttcgccg cctccccgcc atggcggatt catgcgcccc
     5281 cagagcgagc cgaccgaaac gatcacatgg tcacgcagtc ggccacggat ctacgccagg
     5341 ccagcagccg gtaaagggtg tgaaaaatgt ggagggtgat ggcgcaaaac cgcctcagtc
     5401 gtctacatgc atcgcacaaa cgtttctaga gtgatccaca ggttggccgt tcaccgcatg
     5461 tcgcatgccg catgccgaga acaggccata tcgaacaaac ggggagaaag tatggcgagt
     5521 cgcattgtcg ttgcaggcaa gtccctccta acggcggaga tgatggctga gtcgctcagc
     5581 cgggcggagg accttgctgt cgtcaccgtc gtcagcaact tccagaaact ggtcgaagtc
     5641 gtcgagcgca aagatgcgga cgccgccctc atcgacccgg aaaggctcca cggcgactgc
     5701 atggctgcgg cctgcgagat acgcagggtg cggccgctgt gcggagtggc actgatcgtg
     5761 gacgctccga cgcggacctt cgtggaccag gctctgggag ccggcgtgct gagcatcatc
     5821 cccaggtcgg ccgggctgcg gagactgatc gactccgtgc gcggtgtcgc gtcgggacag
     5881 gtggtcatgg acccgcagct gctgtccgca gcgggccgcc aggacggtcc gttgtccgac
     5941 cgcgaggcgg acgtgctgcg gctcactgca tcgggcgcct cggtgaagga gatgtcgggg
     6001 gagctctatc tgtcgtcggg aacgatccgc aatctggcct cgggggcgat caagaagctg
     6061 ggcgcccgca accgctacga cgcggtgcgc atagccagcg aacagtgttg gatctgaccc
     6121 ggcgggacca ggcagccgaa tgagccggtt cccggcggcg gcacccccgc cgggaaccgg
     6181 ctcgcacgtt cactgctcgc ggcagaactc gtctatcgga tagccgacat gacggtcggc
     6241 cgtcggcaga tgcccgagga tcctgtcccc cgggcggagc tccgtgctgt tgagcacggc
     6301 acccccggga ccgaggaccc tgacgtgcca gtcgtcctgg aggatgaggt tcaccgtctg
     6361 cccgttgggc gccaccgcgt ccacggagat cagcggccgc gtctcgatct tgacccgtcc
     6421 cacgctgacc acgcgggtac gccccttcgt gtcgacggcc agcaccttgc tgcccgcgac
     6481 gagttcgctg aggtagttgg ttcggccgtg ctgcgagacg gtgtaggagt ggatcgcgcc
     6541 cgcgttgacc cggaagggtc tcgtcggcat gtagggcagc ggatgggtct cactgacgca
     6601 gaggaccatg cccttcgagt gcgagccgac gaggatgccc tcgtccttcc ccaggtagct
     6661 gcaggtgtcg acgcaggcac gctcgcccat gccgatgtgg gcggtcgccg tgacctccag
     6721 ttcgacgagc gggatctccc cggccgtcgt accggcggcc cggcgcagcg cggtcgcgtc
     6781 gccgacggtc cgcgccggca tcagtacgcc gtccgagccg agttcgagca cgccgtagac
     6841 gatctcggcc tccgtcacgt cggcggccat ggtcacgatg gtgccgtcgc agccggctgc
     6901 cgccgcgatc acgatctcca gcggaatctt cgtgggatcc cggaagtcga gcaggctcca
     6961 ctgttcggtc cgggccgact cacaggcctg ctccagggtc tccgcgtcga cgatctccac
     7021 gtagcggccg aagtccaccc ccggatacgc ccgcgccagc ttcgcgcggt cgtcggcgcc
     7081 gcccgccacc aggacgagat cggcgccgtc gaagccgtcg gccggctcgc ccgcgtcgtg
     7141 gacgaggacg cgccggaccg tgggcggcag gccggcgagc accgccgtgt cggcggtgac
     7201 gacggcgtcg atgcgttggt gcacggcctc ctcgagaacg gccggcgtga gatcgccggt
     7261 cttgcgtacg tcaagccagc acagtctgct gtccgtcatg ctgatgtccc ctcgtcacgt
     7321 ggccgaccgt gtcggcgcct tccacggttt ccgctgatgc gccgcccggt gcgtccggca
     7381 gccggtgcac gagccgcgcc acccgcgccg ccgtccgctg cgggtccgcg gactggaaga
     7441 tgctgcgccc catggcgacg ccgagcgcgc cgcccgcgac ggcctccgag acgaagccga
     7501 gcagcccctc ctccgtggcc cgcggcggac cgccggcgag gaggaccgga acggggcagg
     7561 cggcggtcag cgccatcaga tcgggcaggg aacccgggaa gaccgtcttg accaggtcgg
     7621 ctcccaggtc tgccgcgatc gtgaccgcgt gcgccacgag ttccgggtgg tgcggctcgt
     7681 ggatccgggg gccgcgcgga tacaccatgg ccatgagcgg caggttccag cggtcgcagg
     7741 cgtcggagac ccggccgagg tcggcgatct ggcggcgctc gtcgtcggaa cccagattga
     7801 cgtgcacgct caccgcgtcc gcccccagcc gcagcgcctc ctccacctcc gtgaccaggt
     7861 acttggcgtc cgggtccggc gcctgccccg tactcgcgtt gagatggacg atcagcgaca
     7921 tgccggcgag gcgctccgga cggatgtgcc gcaggctgcc cttgtgcacc acgatcgcgt
     7981 ccaccccggc cgcggcgagc tgctgggcga gcgtgtcgat cgagctgttc ctcggcacca
     8041 cgggaccgtc gctgatggag tggtccaggg gcgtgaccat cagtccggac ggggtgtggt
     8101 gatgcagccg tcgcaggcgc aacgaccgcg cgaaatgtcc ttgagggatc attgcacttc
     8161 cttttggcct ctgaggcgtg cgtaatcggg ttttccggag gggttgagcg ggatttcctc
     8221 ccaccagtca aatgcgtccg ggacatgtgc cgccgagagt tcgacggcga tgtgggagcg
     8281 caactcgtca ccggtgcagc gggctcccgg gcgcagttgg accgccgcct ccaggcgttc
     8341 gatgaactcc tcgccacgcg ttccgtacac gacggaattc ctgacggccg gatggttcag
     8401 cagaacgtcc tggacggtcg tcggatgaac ctttatgccg ttcactttga cgacactgcc
     8461 gatgcggccg accaggtgca gatatccgta cttgtcccag tggccgaggt ctccggtgcg
     8521 aagcaggtcg ccctctttcg tgaggcagcc gcggtccgtc tcgccgaggt agccgtccat
     8581 gagtgtgggc gagcggacgc agatctcgcc cgtcgcgccc cgctcgaccg gtttcccgga
     8641 gccggggtgc cggatctcca tctccaccca ggggaagggg cggccgacgc tgggcagcag
     8701 ctccggctcg cagtggtcga gcggggtgag cgtgcacatg ccgccggcct cggtgcttcc
     8761 gtagagctgg accagcgtct cgccgaagat ccgcgcggcc tcggccgtcc gggcgggggc
     8821 cgccgccgta ccgctgtaga ggacctggcg caggaacggg aaggcggccc ggtcgagacc
     8881 cggctggtcg atgagccggt agaggtgcgg caccgcgagg tagacgtcgg tcacctgccg
     8941 ctcggcgagc gcgcgcagca cgtcgtccac gtcgaagccg ttgtgcagca cgaccgatcc
     9001 gcccgcggcg agcgccgcgt cgaccatcgt cgccgtggcg tggctgatcg gcgtcaccga
     9061 caggagcgtg gggcggtgtt cgggcgggcg cgtcccgaac gacaggtcga cgagctgtcc
     9121 gcgcaccccg aacgaccggc gtacgagctt gggactgccg gtggtgccgc tggtcaggtc
     9181 gatgacggcc gggttctcgg cgacgaaggg ggccgccgcg ggcagcgggt cacggccgct
     9241 cgtggcggcg gcccggctca gggccagcag gacggtgccc ggccggccgt cgcacagttc
     9301 ctgaccgcgc ggggagttgg gctcgtccgc cagcaccacg cgcgcaccgg tggcgtccag
     9361 cagccgggcc tgttcggcgg ccggcagttc gtcctcgtcg ctgcgcgcgt tcatcgaccg
     9421 gatgtggacg acggctgcgc cgagcagatg cgccgcgtac cgcgcggcga gcatggcggg
     9481 ggagttgggc tcggtgagga cggccacggt gtcggcgggg ccgactccgg cccgggtgag
     9541 gcgggctgcg gcgtccgcga cgcaccggcg gaactccgca gcggtgaggt cgccgttcca
     9601 ggaatgcacg acggtcctcg ccggatcggc gccgaggtgt tccagaatgc gcagcacgta
     9661 gttccgcttt tggtccgtgt tctcgctcag cgcctgtccc gcagacattt ccgccccatc
     9721 cgtcccgcct tttgtccgac ttcctcctgt gaggtaatca gtgacaatac tgagaggccg
     9781 ggaaggagtg cgcaagcata cggaggccac tgatgacaaa catcatcgcc tgtgaaacag
     9841 aggtaattcg ctgggacccg tggaggaaat cacggcagca ccgcgtgcaa tccccatgac
     9901 caatgtcacc gatttcctga tcgacgtcat cgcgtccttg cgggcgctgc ggggtgagac
     9961 aggaccatgg tgcgtcggtc ccagtgatgc ggaggttggt atgcggcctg gtaccccatg
    10021 gcccgaagca tggcccgaag tcgagtgcgc cgagtactcg gtgggtttcc gggacgacgt
    10081 ccgggtcggt ttcgacgccg cgtcggtgag cctcaccacg ccggcgagca ccttcgccgt
    10141 gcggatgccc gaggggccca cccgtgacgc cctcgcctcg ctcgccggcg gtcacgtccc
    10201 gctcggggag ctgctcgacg gattcgagcc cgccgaacgc tcccgcttcc agggcctgct
    10261 gggacgtctg ggccggctgg tcgagtacgg cgtggccgtc ggcgggcggg acttgatccg
    10321 cctccagcag acgggactgg aggccgatcc ggtggccggg accgtgcggc cggacgacgt
    10381 cgtgcgcctg tcgcggttcg ccctgtgccg cagcaggtcc ggggtgctgg cgctggagtc
    10441 gccactggcg acggcgcgag cgctgctgga ccaccgggcc gcccgggtcc tcgtctcctc
    10501 gctggccgcc gagcagcgcg tcggcgacct cgccgagcag gtcgccgccg atgccgcgct
    10561 gccggacacc tgcgcactcc tgggtgtcct ggccggcgcc ggactcgtcg acgtccgtcg
    10621 cgcggacggg gcgttcgacg aggagggccc ggcgctgcgg cagtgggagt tccacgacct
    10681 gctgttccac tcgcgcatcc gcagcggacg ccacgacgcc ccgctgggcg gcacgttccc
    10741 gcaccgcggc aggctcgcac cgcaacccgc ggtcaagccg gtgcccgacg gaccggccat
    10801 cgagctgtac cgcccctcac tggaagcgat cacggaacgc gatcccggtc tgacggcggc
    10861 gctcgaaggc cgcagatcgt tccggagcta cggcgatcgg ccgctcaccg ccgagcagat
    10921 cggcgagttc ctctaccggg tcggccgggt caggacgctc ttcgtgcccg cggccggcga
    10981 cgagccgggc ggtgagatcg tctcgcggcc ctaccccacc ggcggctcgt cctacgagct
    11041 ggagctgtac ctgaccgtcc agcgctgtgc cggcgtcgag ccgggcatct actactacga
    11101 ccccgtcgca caccgcctcg tgctggtgaa cgacgcgtac cgggaccgtc gcgcgatgct
    11161 ggaggcggcg tccgtcgcga ccgcccggga ggccgacccc gacctcctca tcaccatgac
    11221 gtcccggttc cagcggctgt cctggaagta cagcggcatg gcctacgcga cgaccctgcg
    11281 gcacaccggg gtgctgtacc agaccatgta cctcgtggcg acggccatgg gcctggcccc
    11341 gtgcgggctc ggcatcggga acgcggacat gtcggcgcgc gtgctgggcc tcgactacct
    11401 gcgggagtcg tccgtgggcg acttcatcct gggcagccgg cccccgggcg acccgggaat
    11461 ctgggatccg gcgcaggggt gggagtgggt caacgacccg cagtgggcgg cctgggccgg
    11521 aacggaactg ggacgcacct gaccgccacg gcgcgcgcgt gaacgacgcc tccaccgaaa
    11581 cggtgggggc gttttcgcgg tccgcacgga aacagttcac gatggaataa cgaattcctt
    11641 ttgagctgcg tgatatcggt aaccgcggat gtgacaagtg tcaatcgcaa tgcttttact
    11701 gtggccctgc ggcggaaatt tagaaatagt tgccctgtgt ggccgaccgg ccgcagctgt
    11761 aaaacagtaa ggagtttcca tgagcaccgt cgcgatcgac tcggccgaca tcgagcaggt
    11821 cttcgactcg ttcgacgtga ccgaactgga ggtcctcgag gtctcgcagg gcgtcgccct
    11881 tcccgagatg ggcgcgtccg gcggcaccgt cggcacgtcg tcctcctcgt cgacctgctc
    11941 ctcgtccacc tgctgacgaa ggccggacgg ccggcccggt gagacggacg gcggtgtccg
    12001 ctcccctcgg agagggggcg ggcaccgccg tcatcgggac accgcgggcc gggcctcagc
    12061 ccttgcgggc aacgtgcaac gcggtggtcc acagcacgag ggccgcaccg aagcccagca
    12121 ggacacggcc gttcgaaccg tcgccgccgc cgagcgccac cgctccgacc agcgcgagcg
    12181 ccatcagcag cccgcccgtc caccagtact gcggctgggc gaaggtccgc gcgagcggca
    12241 ggaagtgcgc cccgacgacc aggcacacga cggcggggac gtactcccac tgctcgaagc
    12301 gtcccaggag cagcacggct gcgacgatcg ccacggtctg gccgatgttg acccggccga
    12361 agacctggaa gctgttgacc gccacccggc gcacgcgccg cggccccggc agccggccga
    12421 ggcggacggt gagcaccacc gcggtgacgg ccacgacgac cgccagggcg gctatccccg
    12481 acaggaccgg tgacggcacc cgcggcccga tgcccgcgac ccccaggcct tcccacatcg
    12541 acgcgaaaac ggacatggcg accgccccct gcaagggccg attgccgctc agtttccgcc
    12601 tgccggattc atcgatcacc cggtcatcct atcccgctgt tccggcgcga aacgcggcac
    12661 aggtgtcacg aagcgcatga cggatgtcag taattgagtg gccccctctt tatggctgcc
    12721 ttcgatttct tgaaagatga gttcccatga gagccaatgc gccagaagac cgtatcgacg
    12781 ccccggcgtc gggccgcctc accggggtcc ggctcttcac cagggcgccg gtgacactgg
    12841 cgtggctcgc cgcgtcggcg gtgcccgtcg cccggtcggt acgggagaac ggcggcgccg
    12901 tcgtacgact gcggcgggga tggctgcacg gaccccacgt cgacgtcgtc ggacgcggcg
    12961 cgctcgggca ggaactcccc tggcggtccc tcgcgcggcg gctggacgcc ggtccgctgc
    13021 ccgccgaccg ggcgctggac gaggagaagt atctcgcgca ggcacgggag ttcggccgcc
    13081 tggaggcagt cgcaccgccg tatctcccga tgcgcgagca cggcgaggtc gagttcctcg
    13141 ggcccgacga cggggaggtg cgcgaccccc tgctgcggga tctgcgcgag gcagagatcg
    13201 tgcacggcgt cctgtgcccg ccgctgatga acaccatcga ggaactggcc aaggacccgt
    13261 ccctggccac cgcccggctc gcggaggcgt tcctcgcgct gggggactcc tacttcctgg
    13321 gcctggccca cggcgccttc tccttccgct cgcactccga ggcgttcctc gcctgggcgg
    13381 ctcccagcaa ggacatgcgc cccgtgttcg ccgcgcggcg ggccaaggag gcgcccgtgc
    13441 tgcgcgagct ggtggagcag cgcctcgccg gacgggtggg tccggcggcg gccgagtggc
    13501 gtacggcctt cgcgtactcc acgggggcgc tggacagcgc ggtggtggac ggccggctga
    13561 cccccgcggt gctggacgcg gtcaactcgg ccgtggacac caccgccatg gggccgccgg
    13621 cggcgccgga cgcggtgccg cggggtgagc accccgacac cgagttccac cgcgccacgg
    13681 cggagtccgg ggtgatcgac gacccgacgc cgtggttcgc cgcgtaccgc ctgctgatca
    13741 acctcttcta ccagcagctg ccgctgctca ccgtctctcc gatccagcgc tactacatgt
    13801 gctatgcgct cgccgagacc atcgacgagg tcctcggcga gacctggcag gagcgcctgg
    13861 ccaaggggcg ggcgcggtgg gaacggaccc ggaggaccac ccgatgacgg cactggagac
    13921 gtgtaccgcc ggggcaccgc agtccgtgtc cggcagcccg cagaaggaac ccctgtggct
    13981 gctgcgcatc aatcccctga gccgtgtccg gctggccgat gagggactgc gcggccttct
    14041 ggcccgcctc gagcaggcgg aacgcgacgt gcggtccgcc gccgaccggt gctccgacga
    14101 gctctacggc ctcatcgggg agaccaccga cgacaccgcg cgcgggcggc tcatcgccgc
    14161 gcgccgggcc gttcacaacg accgccccct caggaacgcc ccgccgtccg tgctcggcgt
    14221 gccgtccgtg agcgagtggc tccgggcgac ggacgagcgg cgacggctcc gggaggagac
    14281 cgcccgccac tacgagcagg cggccgaccg ggagcgccac cggctcgccg gggtgctggc
    14341 ggacgaacac ctgcgcagct cgctggcgct cgtctcgccc gaggtgtacc aggagtccga
    14401 gcgctaccgg gccgccgtcg cgggccccgg gcggctgtcc gcccgcagcc gcaagtcgga
    14461 gcgcggcctg ctccagtacg tcacgcgggc catggtgcgc acgagccccc tggcccgctt
    14521 caccgccgtg ggtctcgccg tcccggcacc cggcggcatc gacccggggg cggtgggctt
    14581 cgggacggct gcggccttcc ccggcctgga ccgggtcatg gtcggctacg tgctcggggg
    14641 cctgcccgcg gccacgggct ccgcgctgct cgacgcctgg gtctcgctgt cgccgacctc
    14701 ggccctcgac gagagccggg agacgctgta cttcctgcgc ccctccgagt cgggcttcca
    14761 gcgcctgtcc gccccggtca agggcgtcgt ccgagccctc gtcgacgcga cggtcatggg
    14821 tccgcggccc gtgcggtcgg tggtgtcgca cctcgccgag cagaccgggt gcacggccca
    14881 ggacgccgcc aaggccgtac tccagggcgt ccaccagggc atcctgtgca cctacaacga
    14941 gccggaggac ggcgccgccg acctggcgca gctgctgtcc cggcccgggg ccccggggag
    15001 cgagctgctg gacggcgtac ggtgccggct gtcgcggctg gcgaccggcc ccgtcgacga
    15061 gcggcggcat gaactcggcg cgatcgaggc ggacttcgcc cagctcgtcc ggctggcggg
    15121 gcgcccggcg cgggtcaccg tcgaagagga ctacgtactt gcgcccacga ccgtcgactc
    15181 cggtcgctgg cggcggccgc tagccgacct cggcccgacg gtggagctgc tgtcggtctt
    15241 cgactggctg cacgacgtcc gcatcctgac gacggccgcc ttcgtgcagc gcttcggggc
    15301 cggggcgaac gttccgctcg ccaggcacgc cgagtcgctg gtcaaggagg tctcacgacg
    15361 cgcggccctg atggggcagt cgtacgagag cggcgacacc ggcgcgctcg acggtctcgg
    15421 cacccccgat ggcagcctcg aacggctgtt cgcactgcgg caccggatca ccgaggagac
    15481 ccggtcccgc atcacacggg cggtcgacac cggagcggcg gacgtccgcc tgaccgccga
    15541 agaggcgtcg gagctggccg gcggcatgcc cgagcgggtg cgccgtgacc cgatgagcta
    15601 cggggtgatg gtgcaggccg cgggccggca cctggtgttc aacgacggcc tgcccggaca
    15661 cggcatgctc tactcccggt tcctcgacgc cgaccggagc ctgtccggcg aggcgatccc
    15721 ctacctggcc gagcggctga ccgaacggta cgcgtgggac ggcgcacggg tggtggagga
    15781 gcgaggactg caccgcctca acgtgaacgc gcacccgcac gtcctgcccg cgggcatgga
    15841 gcccgacgac tggttcgccc tgcgcctggt ccacgacacg gagcaggaca ccctctgcct
    15901 cgaggacggc gagggccgaa ggacccgcgt actgccgctc ggcacgggcc atccggggct
    15961 ctttccgccg cccctgtccc tcgcgacgtc cctgaccacc ggaggacgac tcaacaacga
    16021 cctcctcgac ggctggttcg gcgcccggcc ccgggacgac gggcagcgca cgctggtgtg
    16081 cccgcggttc tccgtcggcg acgtgctgct gtcccggcgc cgctggtacg gcggcgcgga
    16141 gctgaccgcg gccctgggcg caggccccgc cgaacaggac cggttgctgg cgctgaccgc
    16201 ctggcgtgcc cggcacggcg ttcccgagga agtcgtactc aagacggcgt tcggggcgga
    16261 cgcgccgcgc acgctcaacc cggccgacgt gctgccgcgc cgactccgac acaagccgca
    16321 gtacgtggac ctggtgagcg ccctgagcac ccgggtcctg ccgaagatgc tggaacgccg
    16381 ggccaccgcg cacgagtcgg tcgactacct cgaggaggca cttccgtcgg tcgtggaggg
    16441 aacccacgcg caggagtggg tcgtggagat cggacgccgg ccgggcggcg cgttccagta
    16501 cgagggggag aacggatgag gatgagagcg agaccgtacc tgcactgcgc accggtgccg
    16561 ggcggtgtgt acttcagcgg agcacggacc cagttcgtcc tcaaaggctg ggaccagctg
    16621 ttcaaggtcg cggacgtgtg cgtgcctctc ctggaacggg gcacgaccga ggacgacctg
    16681 gtggccgccc tcggcacgga gcgggccagg cccgtcgtgc gccgtctgac cggcggcctg
    16741 cgcgagcacg ggatgcttct cgacgaggac gtcctgcgcg gcgaccgcac gagcgtggcg
    16801 gaccgggagc gctacgcggg cacgctcgcc tacctggagt cggtgagcgc cgacccgtac
    16861 gccgcgttcg ccgcggtccg cgccgcccgt gtcgtcctgt ccggccccgc cgacgcggta
    16921 cgccccgcgg cccgcgggct gagccgcgcc ggtgtcggcc gggtactggt ccaggacacc
    16981 gccggtcccg aggcctgcga aggggcggac gccgtgctgt ggtgcggccg ggacgaggac
    17041 ggtcccggcg agtacgccgg gcgggttccc ggcggcgtac cggtcgtgcc ggtgctgctc
    17101 ggcgaccgcg tgctgcaggc gggccccgtc gtccacgacg ccgcccagta cgcccggctc
    17161 gccgccttcc gccgccgggt gctcggctgg gcccaggggg aggaactcgg ccccgccgca
    17221 cggccggtgg cggatgcgat gaccggtgcg atcgcggggc agctggtgct cgacgtcctc
    17281 gcggggctcg acgagggccg tacggcccat gtggtgcacg gtgccgacct cgtggcggag
    17341 cgcgtcctgc tgccggccgc cgcaccggtg ggcgggccgc ggacgctcgc cgccgcgccc
    17401 gccgcacccc tgcccgaccc cgacgagacg atcgagcagg tcaacacgct caccgcccgc
    17461 tggaagggcc tgttcaccgc ggcccgcgcg gaacaggacc tcccgcagat gccactggcc
    17521 gtcagggcga cggaaccgcg caccgggacc accggccgga ccgccgtctg ggggccggac
    17581 cagcgcgccg cgacggtcgg cgccgccctg caggtgctgc gcggctccgt cccccaggcc
    17641 gagggggcgg tgggcgccgc cggtgtgacc gaggagcgct ggctcctcga cggagtgctg
    17701 cggctgctcg ccgacgaggc ggaggccgac cacacggtcg tcgacgagaa cgaggagacg
    17761 gcccgtatcc gccgcatcct ccaggagtgg cagcgggacc gcctcaccac ccgggtgttc
    17821 cgcgtccccg gcctcgactg gcgcctcgca cgcgtcggac ccacggccgg cgggactccg
    17881 ttgggcgcct cctgggcctt cgacgcggac agcgcggtcc gtcaggccct gagtacggca
    17941 ctggcccgtg cacaggtgga ggccgcgcac gccggcggtg ccgacgtgcc cccgctcgtc
    18001 acggactccg ccggcgccgc cgacgaggag cggatcggct ccctgcggga gcaggtcctc
    18061 cggctcggcg ccgcgcgggg cgtctcctac gagggcactt cgctgcggag cgatccggtg
    18121 ctcggcgaga ttcccttctg gttcggtccc gtccacgccc gtcagctcac gcaggagccc
    18181 cgccatgcac gatgagcagc accacggacc cggactcgga ggatccgacg gcctctggga
    18241 cgaggccctg cgggggctcg gcgacgcgct ggacgcgaag gtcgtcgcca accgcggctg
    18301 ggacctgagc tgggagcggc tccagtggga gaaggcttcc gccgacggcg aggacctcgt
    18361 gtcggtccgg gtgtacgacg acgaggtcgt cgtcggcccc cgatgggtgc cgggcaccga
    18421 ctccggctgc gcgagctgtg ccgaggtacg cgaacgcacc accgcggagc accccctggc
    18481 gaccgcgctg gacacacccc gcgcggtccc gcgcgcggcc cggcccctgc tgcccctcct
    18541 cctcgccgcg gccgcggcga acctcgccga ccacccgctg ggtccgggag agctgtacgc
    18601 ggtcggtgcc cagtacgtgc gccgccaccg cgtcccgcgc agcttcttct gcccggcctg
    18661 cgccgaccac ggatcggtgg cggccgacga ctggcgtccg gagcccctgg aactgcccgc
    18721 cgaacccctc tcgtccaagg accccacgcg cggcgccggc ggtgcgcacc tggtcgagcc
    18781 cggtgcgctg cgtgagcgcc tcctggacgc caggtacggg ccgatccagg tcatcatgcg
    18841 cgagtcggac gtccccttcg ccatgagcat gtgcctggcg ccggacgccg ccgccccggg
    18901 ccacggccgg gccggtacgt tcgccgaggc cgaccccgtc ggcatcatcg agacctacga
    18961 acggctcggc agcttcccct tcgacacccc gctgctcctt gagcgctccc accgcgaggt
    19021 ggccgcccac gcactcgatc cggtcacgct cggggagcac accgagaagc aactggagca
    19081 ccccgactgc caggtgctcc cgtacacgcc ggacaccccc atggactggg tgtggggcca
    19141 cgacctggcc accggcgagc ccctgctcgt tccggccgag gccggcttct accagtacga
    19201 gcagcgtttc aagctctccc ggcacgcggc ccgcgcggcc cgtgtcgagg cacggcgggc
    19261 ccgcgccgcc ggccaccggc ccgcacccgg gacactgcgc aagtacttcc acgactcgtc
    19321 gagcggatgc gcggccggct cgagcctcac ggaggccgcg ctgcactccc tgctcgaact
    19381 cgccgaacgc gacgcgttcc tgctctcctg gcaccgccgc gagccactgc cccggatcgc
    19441 ggacgcgtcg atcacagacc cggagagccg gagcctgatc gacctgatcc gcacgcgcgg
    19501 cttcgacgtc catgtcctgg tggcccggca ggacatcgac ctgccgatcg tgtgggtgct
    19561 cgtcgtgaac cgccagaacc ccttccccgc ctcgtactcc tccggcggct cgggagcgga
    19621 cccggacacc gcgatccgcg gggccctgcg cgaggtcgcc cagctcgtca ccaacaagat
    19681 gcagtggaac cgggaagagg ccgagcagat gctcgacgac ccctggaagc tcgtggaact
    19741 cgaacagcat ccgcagctct acaccctccc ggagaagctg gcacgcgtca ccgaagtact
    19801 cggcggaccg cagaccacgg tccaggacgc gttccccggc tggccccagg tcctgcgccg
    19861 ggcctccggc gggacggtgc gtggcgcact cgaccacgta cgcgccctgt acgccgccgc
    19921 gggcctggac cggatcgtcc tggtgaacca gaccacccgc gagcacgccg acgccgggat
    19981 atcggtcgcc aaggccgtcg tcccgggcat cctgccgatg tgcttcggcc acgcgcagca
    20041 gcgcctgaag aaccttccac gcctggtggc agcgcttgcc ggcaccccgc aggagaaccg
    20101 ggaaattcct tatgacccac acccgttccc atgaacccgc acaggtccgc cgtgcccccg
    20161 tcgacctgcc ggccccctac ggcgacaaca acatcgaacg cgagccgctg tggtacgcgt
    20221 tcggcgccgg ctccgacgaa ccggccgtgc ccccctggac ccgggtggac cagcccccca
    20281 tgacggcaca cacgcacccg ccgccgccct cgtgcgcaag gggcggctcg tgcgtcgaac
    20341 tgccccgtga aacccacgag ttgctcgacc gtacgcccta cccgcacggc cgggcggccg
    20401 tgcgggatcc ggacgaggcg ctgctccggg cgctcgtcgc gggcttcggt gtgcagtggt
    20461 ccgacccgga cgccgtctac gacccgcacc gcggctacgc ctcgccccgc tgcctctacc
    20521 ccgtccaggt cttcgtcgac gacgggcagc actggcatct gctcgatccc gagcggcaca
    20581 ccctgaccgt gctcaccgcg ggcacccacc gggggcggca gcggcggatc gcgctgaccg
    20641 gcaggtacac ccggatcccg agcggctaca agtggttccg cggctccctg gtgaacctcg
    20701 aactcggcat cgtgctccgg cagctggcgc tggctctcga gctgttcggg ctgtcgggcc
    20761 gggtggtcct gccgcacggg ggctccgccg ccctgctgga cgaactcggc ctgacgcccg
    20821 gctgggagtg gtccctgccc accgtcgtcg agatcggccc cgagtcccgg gagccggccc
    20881 cggcagcgga cgccccgaag cccgaggacc agcccgggaa tcagcccgag gaccagcccg
    20941 aggagcccgc gctgcgggac ctggtgcgcg tcaaccgcac ccaggacttc accgacgccc
    21001 cggcccccct gccatccgcc gtgccggccc gcccggtgcc cggccccggc acggcgtcgt
    21061 gggcggacct gatgtggcgc cgcaactccg gccggatgcc ccgcggcctg ctcggcatga
    21121 gcggccggcg cacccgcgta ccggccggct ccgtcgagga cgccctgcgc tggctcgacg
    21181 ccccgcctcc gggaccgacc ctcgcggccg tggcggacct ggtcaccctc accgtcgtca
    21241 cccaggacgt ggcgggcctc ccggacggca tccaccgggt gcgcgcgggc gagtgtgtcc
    21301 agctgtccgc cgaccgcacc gcggcggccc gcctggaggc ggagtacgga tacgggctga
    21361 gcacggacgc gggctgcgac atccgcaacg cctcggcgat ctggttcatg tccgtgaaac
    21421 cgcgggaact cttcgcccgc ctcggtgcca acgggtggag cgccgcccag tactggtgcg
    21481 gctgggccct gcacggactg tgtctgtcca ccacggccta cgggatgttc acccgcccgg
    21541 tccgcgcctt caacgagata ccggtgcagc ggatcctccg gctgggcccc gacgagatgc
    21601 tcgccctcgc cgcggtggtc ggcacgcccc ggtacccggc ccacgggctg ctggacatca
    21661 gagtctgacg gaggagaaca ccttggaaca gcagacggca cccggcacgc ccacgccgga
    21721 caccggcacc acgtggagcg cgtggcacct gcatgtcgcc tcgaacgccc cgtcactgct
    21781 cgaccgtgtg gtgaaccggg tcgtcgcccc ggtgacgcgg accctggacg gcgcgccctg
    21841 gttcttcatc cgctactggg agggcggccc ccacctgcgg ctgcgcgtgg gggacctggg
    21901 acatgcggag cacgcacggg tggaagcgct gctgcgggac ctgctcgcgg ccgaggggcg
    21961 gccggccggc gacgagcagc cgttcggcga ggaggcgtac cgcgccgcgg ccgggcagct
    22021 ggcccgcgcc gagtacggcg gcgaccaccc cgtcgcggag ctgcgccccc caggcgtgca
    22081 ccgcgccctg tacgaaccgg agaccgcacg gtacggcggc gccgccctga tgccgcggac
    22141 cgagcgtctt ttccagcgat ccagcgaact ggtgctcgcc ctgctgcccc acgtgtcgac
    22201 cccgcagacc cgttccgccc tcgcgctgcg cgccaccgtc tccgcggccg ccgccctcgg
    22261 tgacgacgcc gaacaagccc tgtactacgc ccacagcctg gcggcctggc gtgcctgggc
    22321 ggccggcctg ggcagcacgc ccggggaact cgaccggctg tgccacatcc ccgaagggtc
    22381 cgcccgtccc gtggacccgg accggcacgg ccccttcgag ccctggcacg cggccctgac
    22441 ggagctggtc cgggaggtcc gtgcgacgac ggacagcgtg ccggggcaga tcgtggtctc
    22501 gcacgtgcac atgttccaca accgcctcgg ccgcacactc ttcgacgaac tgcgcaccta
    22561 cgcctggctg gagcgcgcct tcccggcccg gggggtccgg acgtgacccg ccggccgcgt
    22621 atcgccgtgg tcggcgccgg catcggcggt ctgaccctgg cgagggcgct cgccgagtcc
    22681 ggtacgccct gcgaggtgtt cgagcaggcc cgcgcgatga ccgagatcgg tgccggggtg
    22741 cagctcgccc ccaacaccgt ccgcagcctc aggagcctgg gcctcgaagc cgcactcgcc
    22801 cggcacgccg tccccgtcga ggccatgcgc atgtacggct ggcggggcgg gccgatcacc
    22861 gccaccccgt tcggcgccgc ctgcgagacg ctgtacggag cgccctactg cgccgtgcac
    22921 cgcgccgatc tgcaaggggc actgctgacc ctggtcggtc ccgggccgct gcggctcgga
    22981 caccggctgc gggacctctc ccccgacggc gacgagatgg tcctcacctt cgacaacggc
    23041 cgcacgcacc gcgccgacct cgtggtgggc gcggacggca tccattccgt ggtgcgcgaa
    23101 cgcctcgtcc gggacgctcc cgtcttctcc gggctcggtg tcttccgcgg cctggtcccg
    23161 gtcgaccggt tgcccaccgc ggcacggcaa ccactgatca ggatgtggct cggccccggc
    23221 cggcacttcg tctgctaccc ggtgtccggc ggccgcctgc tgagcttcgc cgcgatctct
    23281 ccgctcgcca cggcgggggc ggagtcctgg tccgccgagg gcgacgccac cgcgctgacc
    23341 gaggacttcg acgggtggag cggactcgtg cccgccgtca cccgcgccgt cggcaccgtc
    23401 cgccggtggg cgctgcacga caggccggtc ctgcacacct gggccacgga ccggctcgcc
    23461 gtgctcggcg acgccgcgca ccccatgctc ccgttcatgg cgcagggcgc gaaccaggcg
    23521 gtcgaggacg ccgtggaact ggcctcgctg ctcgcggggg cctccgccga cgagatccct
    23581 gagcggctgc gcgcctacga gctcgtccgt gccccgcgcg cggcggccgt ccagcagggc
    23641 tcacgcggcc actcggagac gatgcacctg cccgacgggc cgcgtcagcg cgaacgggac
    23701 caggccctgc ggcgcaccgg gggactcacc ggactgcgcg aacgcgcctg gctctacggc
    23761 cacgaggccg ggacccgccg cacgccgccg acggcggcca acagtgcggg aacggcgaag
    23821 gaagaggaag aagagggaag gggccccgcc tcatgaagga caccggcctg cgggtcgccg
    23881 tggtcggggc gggagtctcc ggactcgcgc tcgccatcct gctgcggcgc cgcggcgtgc
    23941 actgcgacgt ctacgagaag tccgcggcgc tcggcgcggt gggcgcggga atccagctga
    24001 ccccgaacgg cgcccgcgtc cttggcgaac tcggcgccga ggagccgctg cgccgcaggg
    24061 gcatcacggc gaacgccatc gagtcgcgcc gctggagcga cggcgcgatg ctgtcccgtg
    24121 tcccgttcgg cgacgcctgc gtcgaccggt tcggggcccc ctaccacctc gtccaccgcg
    24181 ccgacctgca ggcctgcctc atggatctgc tgccgcccgg cggtctgtac ctgggacgga
    24241 cggtggacgg cgtcacggac cacggcgacc gcgcggacct gcggttcacc gacggcacga
    24301 cggtgaccgc cgacgtggtg atcggcgccg acggcgtgca ctccgccgtg cgcggcgcgg
    24361 tgctggacga ccggccggtg tactgcggct actcggtgta ccggggtctc gtaccggccg
    24421 gcgcggtgcc ctccttcacc ggggacccgc gcgtgatgtt ctggttcgga ccgggccgtc
    24481 atgtgacctg ctatcccgtc tcgtccggcc gtacggtcca cttcagcgcg gtctgcgccg
    24541 acccgtacgc cggcaccggc ccgcgcagtg cggtcgccgg tgccggcgaa ctcatggccg
    24601 agttcggcgg ctggcacgag gatgtccggc gggttctgcg tgctgcggac tcggtgacgc
    24661 gctggggcct cttcgaccgg gacctccccg gccggtacgt caccggccgg gtggccctgg
    24721 ccggtgacgc ggcgcatccg ctcctgccgt tcctctccca gggcgcgggc caggcgctgg
    24781 aggacgccgt cgtcctggcg gacgtcctca ccgcacacgg tgacgacgtg ccgggtgcgc
    24841 tgcgcgcgta cgaggccgtc cggatgcccc gcaccgccga ggtgcaccgc cagtcacggc
    24901 tgcgggccgg caccttccac ctcccggacg ggccggagca aaccgcccgt gacactcagt
    24961 gggcgcgtac ccaggacctg tgccacctgg actggctcta cggcgccacg gtccgtccgg
    25021 caccggccct caccaggagc tgaccgaagc gacgggcggc gccaccggag gtggcaccgc
    25081 ccgcacgcgt gtccgtggct cactcgggcc gagggtccca gcggaaccgc cgtacggcca
    25141 cgaccgcgcc caggacgccc cacgcggcca gcacccccag cccccgccag ccatgaccgg
    25201 acgcaccggt gaaggcggcc agcagtgcct cgttgaaagg cttgaccggg agcagacctg
    25261 cgatcgtgtt cagcgcgtcg gcgtgtacgg ggaagtagct gcccgagatg aacaccagcg
    25321 ggaactggat gaactgcacc agcgccggag ccgattcggc actcctgacc agtgaggcga
    25381 caccggcgcc gagggcgcag aagctcgcgg cacccagcac cagggccagg gcgagccccg
    25441 cccagtgcgc gggcagcggt acgccgtaca gcgtgcccac cccgatgacc agcccgatgt
    25501 cgatggcgcc gaccagcagg cagtgcgcca gcagaccggt gaagtagatc caggccggca
    25561 gcggagtcgc ccgcaaccgc ttgagcatgc ccgtctgccg ccgggtcgac agcacgatgg
    25621 ccagctggcc gtagcaggcg cccagtacgg agaccgcagc gatcgtcggc gtgtagtact
    25681 gcatgccgga cagcccgaag tagaagtccg acttctggtc accgccgaac accgctccga
    25741 agacggtgac gaccagcacc ggcagcagaa acgtgaagat cacggcctgc gggttgcgcc
    25801 agaaggaaag ctgctcgtag cggatctggt gggccaccag acgcaggcga ccccggccga
    25861 cggcggtgcc cggggcggcg tccggggctg tggcggcggc cggggccggc gaggagacgg
    25921 tcatgtacgg ctccgcttcc gtcggcgtcc gcgcacggcg gcggactgct ggggctgctg
    25981 ggactgcgct gcttcgcccg tctcgaagga gcgggtgatc tccaggtaga cgtcctccag
    26041 ggacggccgc tcgacggtca gccgcccgag cgtcgtgccg cgctccaggg cccagccggt
    26101 gagggagtgc agcacggccg tcggttcccg cacttcgagg tggaccatgc cgtcgacgac
    26161 cggcggggcc gtcggcaacg gcaggtccag gacccccgta cccggcggca gctcgaaacg
    26221 gatgcgggcg aacgccttgt ccctcccccc gagcgtggcc ggcgtgcccg agtcgacgat
    26281 ccggccgtcc gcgatcacgg tgacggagtc ggcgagcgcc tgcacctcgt ccatgtagtg
    26341 cgtcgtcagc acgatggtgg tgccggagtc ccgcaggtcc cgcaccagct cccaggcact
    26401 gcgccgggcg ctggggtcga agccggtggt gggctcgtcg aggaacagca gactgggatt
    26461 gccgaccacg ccgagcgcca ggtccagacg ccgcttctgc ccgccggaca ggtccttgac
    26521 cttggctctc cgcttctccc gcagcccgac cagctcgatg accccgtcga cgtcccgggg
    26581 cgcccggtag tacccggcgt cgcgtgcgat cgtctcgcgc acggagagat atggttcgac
    26641 ggctgtgtcc tgcagaacga tcccgacccg ctcccgcagc tcgtgggcga ccgcggacga
    26701 ccgcgggtcc ataccgagca cctccacgcg gccctcgtcc cggccgcgga agccctccag
    26761 gatctccagg gtcgtcgtct tgcccgcgcc gttggggccc agcagcgcga agatctcgcc
    26821 ctccgtcacg gcgaagtcga tcccgagcag cacgtcgcgg ctcccgtagg cctttcgcag
    26881 cccttccacc accaccgccg tcaccgcggc cgcccccgtt cgtccatgtc gctcctccgt
    26941 aacctgctcc ggtcgccgac gcgtggaccg cgggcgatgt ccgaccgtag ggcgacgaca
    27001 cggcccgggg agggcggagc gggggagccg gtgacgcacg tcatgaaagg ggggacagtt
    27061 gtcaaccggc gccgccacgg cgcccgcgcg ggcgccgtgg caaaagcgtt cgccaggaat
    27121 ttcccgggga tgagatcctg ggacccgtat gtctacgcac cctgcccccg ccctcggcac
    27181 cctcgccccc cggctgaccg agctgtcgct gcgcgacgcg caccggctcg gccggaggct
    27241 ggagggtgca cgcaagatcc gtaagccgga ggcccgcgcc accgtcctcg ccgagatcga
    27301 ggcggaggtg gccaaggccg agcagcgcat cggtgagcgc cgggcgcggg tgcccgacgt
    27361 gagctacccc gcgcagttgc ccgtcagtca gaagaaggac gagatcgcgg ccgccatccg
    27421 cgatcaccag gtcgtgatcg tcgccggtga gaccgggtcc ggcaagacca cgcagatccc
    27481 gaagatctgc gtggagctgg gccgcggcgt gcgcgggatg atcgggcaca cccagccccg
    27541 ccggatcgcc gcgcgcaccg tcgccgagcg ggtggcggac gagctggaca ccccgctcgg
    27601 ggagaccgtc ggctggaagg tgcgcttcac cgaccaggtg aatcccgagt ccaccttcat
    27661 caagctgatg acggacggca tcctgctcgc cgagatccag accgaccgcg agctgcgcgc
    27721 ctacgacacg atcatcatcg acgaggccca cgagcggtcc ctcaacatcg acttcctgct
    27781 gggttacctc gcccagctgc tgcccaagcg gccggacctg aaggtcgtca tcacgtcggc
    27841 gaccatcgac cccgagcgct tctcgcgcca cttcggcgac gcgccgatcg tcgaggtgag
    27901 cgggcgcacg tatccggtgg aggtgcggta ccggccgctc ctcgaagagg acggcgacga
    27961 cgccgaccgg gaccagatca ccgcgatcac cgacgccgtc gaggagctga tgggcgaggg
    28021 gaacggagac atcctcgtct tcctctccgg cgagcgggag atccgggaca cggcggacgc
    28081 gctggagaag aagaagtaca gaggcaccga ggtgctgccc ctgtatgcgc ggttgtcgca
    28141 cgccgagcag caccgggtgt tccagcggca ctcggggcgg cggatcgtgc tcgcgaccaa
    28201 cgtcgcggag acgtcgctga ccgtgccggg catcaagtac gtcatcgacc ccgggttcgc
    28261 ccggatctcc cggtacagcc accgcaccaa ggtgcagcgg ctgccgatcg agccggtctc
    28321 gcaggccagc gccaaccagc gcaagggccg ctgcgggcgg accagcgacg gcatctgcgt
    28381 ccggctgtac tccgaggacg acttcgacgc gcgcccggag ttcacggacg cggagatcct
    28441 gcggaccaac ctcgcctccg tcatcctgca gatgaccgcg gcgggcctgg gcgacatcga
    28501 gaagttcccc ttcatcgacc cgccggacca ccgcaacatc cgcgacggcg tacagctcct
    28561 ccaggagctg ggcgcgctcg acccggcgca gaaggacgtg cgcaagcggc tgaccgacac
    28621 cggccgcaag ctggcccagc tgcccgtcga cccgcggctg gcgcggatgg tcctggaggc
    28681 cgaccgcaac ggctgcgccc gcgaggtcat ggtcatagcg gcggcgctgt ccatccagga
    28741 cccgcgggag cggccggcgg agaagcaggc gcaggccgac cagcagcacg cccgcttcaa
    28801 ggacgagacc agcgacttcc tggccttcct caacctctgg cggtatctgc gcgagcagca
    28861 gaaggagcgg ggctcgtcgt ccttccgccg gatgtgcaag caggagtacc tgaacttcct
    28921 gcggatccgc gagtggcagg acatctacac gcagctgcgc acggtcgcca agcagatggg
    28981 catccgcctc aacgacgacg acgcccccgg cgaccgcgtg cacgtctcgc tgctggcggg
    29041 gctcctctcc cacgtcggca tgaaggacgt gaaggagggc gcgaagaacg agtacctggg
    29101 cgcgcgcaac gccaagttcg cgatcttccc ggggtcggcg ctgttcaaga agccgccgcg
    29161 gttcgtgatg tcggcggagc tggtggagac gtcccgcctg tgggcccgcg tcaacgcgaa
    29221 gatcgagccg gagtgggtgg agccgctcgc cggacacctc ctcaagcaca cctacagcga
    29281 gccgcactgg gagaaggacc aggcggccgt gatggcgtac gagaaggtga cgctgtacgg
    29341 cgtgccgatc gtggcgcagc gcaaggtgaa ctacgggcgg atcgacccgg aggtcagccg
    29401 tgagctgttc atccgcaacg ccctggtgga gggcgactgg cgcacgcacc acaagttctt
    29461 cgcggacaac cgcaggctcc tgacggaggt cgaggagctg gagcaccggg cgcggcgccg
    29521 ggacatcctg gtcgacgacg agacgctgta cgacttctac gaccagcggg tgcccgaaca
    29581 cgtcgtctcc ggtgcgcact tcgactcctg gtggaagcac aagcggcacg accggccgga
    29641 cttcctcgac ttcgagcgcg agatgctcat caacgagaag gcgggggcgg tcaccaagga
    29701 cgactatccg gatacctggc gccagggtcc gctgaagttc cgggtgacgt accagttcga
    29761 gccgggtgcg gacgcggacg gcgtgaccgt gcacgtgccg ctgcaggtgc tcaaccaggt
    29821 cgcggacgag ggcttcgact ggcagatccc ggggctgcgg gagcaggtcg tcacggagct
    29881 gatccggtcc ctgccgaagc ccatccgccg gcactacgtc ccggcgccga actacgcgca
    29941 ggcgttcctg gaccgggccg tgccccttca ggagccgctg gcggtgacca tggcgcggga
    30001 gctgaagcgc agggtggggg tgccgctgga ggcggaggac ttcgactggg ccaaggtgcc
    30061 cgaccatctg aagatcacgt tccggatcgt cgacgagcgg cggcgcaagc tggcggagga
    30121 caaggacctg gaggcgctga agctgcagct gcggccgaag gcccgcaagg cgctgtcgca
    30181 ggcggccgcg gccaccgccg tgcgcagtgg cggcgagtcg ctggagcgta cgggtctgac
    30241 ggactggacc atcggcacgc tctcccgggt cttcgagacg cgccgggccg gtcagcccgt
    30301 gaaggcgtac ccggcgctgg tggacgacgg gccgaaggcg aacaccgtct cggtacggct
    30361 cttcgacacc gaggccgagc aggcgcaggc catgtggaag ggcacgcgcc ggctgatcct
    30421 gcgcaacatc ccggtcaacc cggcgaagtt cgcgtccgag aagctcacca accagcagaa
    30481 gctggggctg tccgcgaatc cgcacggctc gatccaggcg ctgttcgacg actgcgcgac
    30541 ggccgcggcg gacaagctcg tcgcggactt cggcggcccg gcgtgggacg aggagtcgta
    30601 ccggaagctc tacgacaagg tccgcgcgga gatcgtcgac acgaccgtac gtacggtggg
    30661 ccaggtgcag caggtgctgg ccgcctggca ggcctgtgag cgccggctga aggccgtgcg
    30721 cagcccggcg ctgctggcga acctcgcgga cgtacgcgcg cagttggacg cgctggtgaa
    30781 gccgggcttc gtgacggagg cgggcatccg gcggctgccg gacctgctgc gctacctggt
    30841 cgcggcggac cggcggctgc agcagatgcc gaccggtgtc ccgcgggaca cctcgcgcat
    30901 ggagaaggtg cacgagatgc gcgacgagta cgcgtggctc cttgagcaga tgccgcgggg
    30961 ccggccggtt ccgcagcagg tactggacgt gcgctggatg atcgaggagc tccgggtcag
    31021 ctatttcgcg cacgcgctgg gcacggcgta ccccgtttcc gacaagcgga tcgtgaaggc
    31081 catcgacgcc ctggcgccgt gacggggcct gcacggaggg tgagttcgac cggtggcccg
    31141 ccctcctgta cagtctcttt tcgcagcgca acgcagaaga cgcgccgcga aacctggtcc
    31201 tgtggagcag tttggagtgc tcgccaccct gtcaaggtgg aggccgcggg ttcaaatccc
    31261 gtcaggaccg cagtgaggcc ccgtaccgtt caaacggtgc ggggctttcc cgtgcccgaa
    31321 ccaaccccag accgcaggcc gcgcccgcgg cgcagccgca gtccgacacg gcaaatcccg
    31381 tcaggaccgc agtcaagccc cgtgtcgatc atcgacacgg ggctttttcg tgcacccccg
    31441 cacccccgca cccgatgccc agcattcagc gctcggcgca ccctctccca actccccagc
    31501 ccctcgcgcc cccagaggcc ctcagtgccc ctctcgcggc cttgacggcg tcacattcgc
    31561 tcggtactcc aaagacaggg caagctcccc gtgtggcccc ctggaggcgg cgtatggcgg
    31621 catcggtcag gcacgagacg cgggccctgc tccgcgcgca tctgtcggcc gcgtcgtcgt
    31681 acggccatgc gacgcggcac tgcccgatct gccaccggct gctgcggctc gcactggacg
    31741 ctccggcgcc gcggcttccc gtcgcacagt taccgacggg acgtcaagaa ggcgtcgagg
    31801 acgggagcac ccccacggcc tgatgcctgc cggcccccaa cacccttgcc ccgcagacct
    31861 cctggaggtc aggcttccat tagcgcacgg acgccgggat caacaaccac cctgccgtgt
    31921 gatgggtgtc accccatgag tttccggaac cgtggcactt accaagctcc tacaaccggt
    31981 caatttaata tgtgcaattg caccaacact cgcagtactc gcacagccga tccgacaccc
    32041 ctccccagac tccgacaagg ccgctcacag ggcgacccgg cagtccgcca cagtcgacca
    32101 ggcactccac cggcggacac gcgaccggac acaaaaagat cgcgctggac ccggcggagt
    32161 ccagcgcgat caacgacgca cccctgttgg ggcaggaacg gcgtcgcttg aagctgtgtt
    32221 ccaggcgcct cgacagatgg gggacctgcc gttttgcccg gttattcagt tgttcaggct
    32281 tcgctgcgct gctgcggaat gcccgcgagc agggcgcgga cctcggcttc gcggtagcgg
    32341 cgatgcccgc cgagcgtgcg gatcgacgtg agcttgccgg ccttcgccca gcgcgtgacc
    32401 gtcttcgggt cgacgcggaa catggtggcg acctcagccg gggtcagcag cggctcggca
    32461 tcaggggtgc gagcggtcat gagcggcctc ctcgggagaa ccgaaccttc tcggttcttt
    32521 cctctaaatt ctgcaccttg acccacgttg cccgaaatga gcggacgcga gtcgagtcgg
    32581 ttataggacg aacggcttgt cctcgg
//
