LOCUS       NZ_CP036534            20441 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. VN1 chromosome, complete genome.
ACCESSION   NZ_CP036534
VERSION     NZ_CP036534.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. VN1
  ORGANISM  Streptomyces sp. VN1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8341703)
  AUTHORS   Nguyen,H.T., Pokhrel,A.R., Nguyen,C.T., Pham,V.T.T., Dhakal,D.,
            Lim,H.N., Jung,H.J., Kim,T.S., Yamaguchi,T. and Sohng,J.K.
  TITLE     Streptomyces sp. VN1, a producer of diverse metabolites including
            non-natural furan-type anticancer compound
  JOURNAL   Sci Rep 10 (1), 1756 (2020)
   PUBMED   32019976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8341703)
  AUTHORS   Pokhrel,A.R., Nguyen,H.T., Dhakal,D., Nguyen,C.T., Pham,V.T.T. and
            Sohng,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2019) Department of BT-Convergent Pharmaceutical
            Engineering, Institute of Biomolecule Reconstruction, Sunmoon-Ro221,
            Asan, Chungnam 333-708, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: HGAP3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011650445.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 03:53:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,284
            CDSs (total)                      :: 7,197
            Genes (coding)                    :: 7,083
            CDSs (with protein)               :: 7,083
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 44 of 114
            Pseudo Genes (incomplete)         :: 82 of 114
            Pseudo Genes (internal stop)      :: 3 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:32:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3460125
            Orig. end                         :: 3480566
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036534.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jae Kyung Sohng.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20441
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phenazine"
                     /region_number="13"
                     /rules="phzB"
                     /tool="antismash"
     cand_cluster    1..20441
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="phzB"
                     /kind="single"
                     /product="phenazine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20441
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10441](+)"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10441
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="1"
     gene            335..835
                     /locus_tag="EZV63_RS15210"
                     /old_locus_tag="EZV63_15390"
     CDS             335..835
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009189284.1"
                     /locus_tag="EZV63_RS15210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15390"
                     /product="hypothetical protein"
                     /protein_id="WP_031038238.1"
                     /transl_table=11
                     /translation="MLDIGYALSTRFPDPPQTDYRRADVRALRHDLFCGDVYLADTEAD
                     RELSTAWGWVPVLDFAWALCDIAERVDRDPAGSRAARPQRAELDFTESADRLLFERRFG
                     WVDIEAEWLPASEPPLSFSHAELRREARDFLQDLLADLTDLHEDLSDNPAVWTLQARFP
                     RIA"
     misc_feature    913..926
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            942..1715
                     /locus_tag="EZV63_RS15215"
                     /old_locus_tag="EZV63_15395"
     CDS             942..1715
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008412403.1"
                     /locus_tag="EZV63_RS15215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15395"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_031038240.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.7e-31,
                     bitscore: 106.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLVSVVMPVYNSAATLGAAVRSVLTQTHGDLELLVTDDQSSDGS
                     MDLLREFAARDERVLPESAPERGGAGRARNLAIERARGDYIAFLDSDDMWLPEKTEKQL
                     AFAAEGRAPLTFTSYFKMDADYDGESTDWVPNGRVIRAREHVDYRAMLVQDHIGALTAM
                     YDHKALGTRLMPEMRKRQDYALWLSIMRDGADARGLAEPLAVYRANQAGSLSSNKLSLV
                     QYNWALYREHEHLSVPRATRALAGAAWQSLRNSRV"
     gene            complement(1798..2778)
                     /locus_tag="EZV63_RS15220"
                     /old_locus_tag="EZV63_15400"
     CDS             complement(1798..2778)
                     /NRPS_PKS="Domain: PKS_ER (15-324). E-value: 9.4e-45.
                     Score: 145.0. Matches aSDomain:
                     nrpspksdomains_EZV63_RS15220_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014140230.1"
                     /locus_tag="EZV63_RS15220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15400"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_166624333.1"
                     /sec_met_domain="ADH_N (E-value: 1.3e-07, bitscore: 30.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.7e-27, bitscore:
                     93.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAFTVRAGGGLTLTTDRPVPDPSAGEVLVKVRATSLNARDRLIV
                     SDSYSVDVRGRVPLSDGAGVVEAVGDGVSRFRVGDRVAGTFHPTWVYGPFPGWGALRGT
                     QRDGWLSDHVVLDQQSLVRIPDRLSFEEAATLPCAALTAWSAVAGVGPGDTLLVQGSGG
                     VSVFALQFARLAGARVVATTSDDDKAERLRALGAADVVNYRETPRWGARVRELTGGGVE
                     RVLEIGGAGTLPQSVEAVAHGGQIALVGNLASGNDMDVTHFFRRAATLRSISVGSRSDF
                     EQMNEALDRSTLRPVIDRVFPFDQASEAFAHFERGPRFGKVVIGH"
     aSDomain        complement(1807..2733)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS15220_PKS_ER.1"
                     /evalue="9.40E-45"
                     /label="EZV63_RS15220_PKS_ER.1"
                     /locus_tag="EZV63_RS15220"
                     /protein_end="324"
                     /protein_start="15"
                     /score="145.0"
                     /tool="antismash"
                     /translation="TDRPVPDPSAGEVLVKVRATSLNARDRLIVSDSYSVDVRGRVPLS
                     DGAGVVEAVGDGVSRFRVGDRVAGTFHPTWVYGPFPGWGALRGTQRDGWLSDHVVLDQQ
                     SLVRIPDRLSFEEAATLPCAALTAWSAVAGVGPGDTLLVQGSGGVSVFALQFARLAGAR
                     VVATTSDDDKAERLRALGAADVVNYRETPRWGARVRELTGGGVERVLEIGGAGTLPQSV
                     EAVAHGGQIALVGNLASGNDMDVTHFFRRAATLRSISVGSRSDFEQMNEALDRSTLRPV
                     IDRVFPFDQASEAFAHFERGPRFGKVVI"
     CDS_motif       complement(2341..2382)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS15220_0001"
                     /evalue="9.10E-03"
                     /label="PKSI-ER_m4"
                     /locus_tag="EZV63_RS15220"
                     /protein_end="146"
                     /protein_start="132"
                     /score="9.7"
                     /tool="antismash"
                     /translation="AATLPCAALTAWSA"
     gene            2881..3831
                     /locus_tag="EZV63_RS15225"
                     /old_locus_tag="EZV63_15405"
     CDS             2881..3831
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024260.4"
                     /locus_tag="EZV63_RS15225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15405"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_166624334.1"
                     /transl_table=11
                     /translation="MDPVDDLLTTMRIEDARYVRVEANAPWGISFPPRHLARLILISDG
                     SCRLDSDVLDRPQRLESNDCFLVRAGVGFTLRDADDSEILDCDDLAAQASGHLVRVGGD
                     GEPTRILSTRFTFDAVAAEPLFALLPPLFRLPPDDASGELLRATFELIEHESSARRLGA
                     GFVMGRLSDALFVQALRTCCADVGSGSVGWVAALRDPRLALAMQELHADLSRSWTVGEL
                     ARTAGMSRSAFATLFRERTGDTPLSYLTAWRMYRVKVLLRETPLSVQEIAVRVGYDTGT
                     ALSRAFSKREGVSPGTWRKTARGADRQEPSSPRQA"
     misc_feature    complement(3873..3888)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            4063..4794
                     /locus_tag="EZV63_RS15230"
                     /old_locus_tag="EZV63_15410"
     CDS             4063..4794
                     /NRPS_PKS="Domain: PKS_KR (2-156). E-value: 4.1e-18. Score:
                     57.9. Matches aSDomain:
                     nrpspksdomains_EZV63_RS15230_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557424.1"
                     /locus_tag="EZV63_RS15230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15410"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_228773744.1"
                     /sec_met_domain="adh_short (E-value: 1.1e-35, bitscore:
                     121.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 7e-38, bitscore:
                     129.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALVTGGSAGLGLAIARRFAAEGAHVYITGRRKEALDAAKASIEG
                     RVTAVAADATDSGDLDDLVEAIRRESGHLDVLVANAGSIERMNFGEVTEEHFDRTFDLN
                     ARGTLFTVQKALPLLRAGASIVLLGSITAFKGDPGAGTYSAAKAAVRSYARTWAAEFAD
                     RGLRVNVLSPGPIDTLIIDGQAEYFGQDPATVRARMSTLVPMGRLGLPEEIAHGALFLA
                     SDESSFMTGAELCIDGGMAQV"
     CDS_motif       4069..4158
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS15230_0001"
                     /evalue="1.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="EZV63_RS15230"
                     /protein_end="32"
                     /protein_start="2"
                     /score="17.5"
                     /tool="antismash"
                     /translation="LVTGGSAGLGLAIARRFAAEGAHVYITGRR"
     aSDomain        4069..4530
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS15230_PKS_KR.1"
                     /evalue="4.10E-18"
                     /label="EZV63_RS15230_PKS_KR.1"
                     /locus_tag="EZV63_RS15230"
                     /protein_end="156"
                     /protein_start="2"
                     /score="57.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVTGGSAGLGLAIARRFAAEGAHVYITGRRKEALDAAKASIEGRV
                     TAVAADATDSGDLDDLVEAIRRESGHLDVLVANAGSIERMNFGEVTEEHFDRTFDLNAR
                     GTLFTVQKALPLLRAGASIVLLGSITAFKGDPGAGTYSAAKAAVRSYART"
     CDS_motif       4438..4527
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS15230_0002"
                     /evalue="2.20E-03"
                     /label="PKSI-KR_m4"
                     /locus_tag="EZV63_RS15230"
                     /protein_end="155"
                     /protein_start="125"
                     /score="10.5"
                     /tool="antismash"
                     /translation="VLLGSITAFKGDPGAGTYSAAKAAVRSYAR"
     gene            4850..5644
                     /locus_tag="EZV63_RS15235"
                     /old_locus_tag="EZV63_15415"
     CDS             4850..5644
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (2-99). E-value: 3.6e-09.
                     Score: 28.5. Matches aSDomain:
                     nrpspksdomains_EZV63_RS15235_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="EZV63_RS15235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15415"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_070388396.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5e-16, bitscore:
                     58.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFLAVHGGCHGAWAWDFVKPEMVKLGHELVSVELPGHGSRLSET
                     ATLDGYREAVVELMEPGDVLVGHSSGSVVAILAANERPDLVSHLCLVAGILPVEGMPLS
                     FERESANPGSGEDPHGGNGAALETYMRMTEDNEAFYFERSGAVSAFYNDCSEDLIDWIF
                     PKLVPEPLAPLAVPISVPNFWAQHDLSRSFIMGSRDTICFPELARLQARRLGVVPLEID
                     AGHSPWLSRPAEFASLLVAATRTKPVGPLVPTSLHAMPEQAG"
     aSDomain        4856..5146
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS15235_Abhydrolase_1.1"
                     /evalue="3.60E-09"
                     /label="EZV63_RS15235_Abhydrolase_1.1"
                     /locus_tag="EZV63_RS15235"
                     /protein_end="99"
                     /protein_start="2"
                     /score="28.5"
                     /tool="antismash"
                     /translation="FLAVHGGCHGAWAWDFVKPEMVKLGHELVSVELPGHGSRLSETAT
                     LDGYREAVVELMEPGDVLVGHSSGSVVAILAANERPDLVSHLCLVAGILPVE"
     CDS_motif       5039..5089
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS15235_0001"
                     /evalue="6.80E-04"
                     /label="NRPS-te1"
                     /locus_tag="EZV63_RS15235"
                     /protein_end="80"
                     /protein_start="63"
                     /score="12.2"
                     /tool="antismash"
                     /translation="VLVGHSSGSVVAILAAN"
     gene            complement(5680..6405)
                     /locus_tag="EZV63_RS15240"
                     /old_locus_tag="EZV63_15420"
     CDS             complement(5680..6405)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016326845.1"
                     /locus_tag="EZV63_RS15240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15420"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_078535956.1"
                     /transl_table=11
                     /translation="MARRAAAGGGTGRSRGTGAGAAKVRAARRPELRLPPLTPYEDGGL
                     EPDGDYDALEFRETDLSGQDAAGARFMDCALTGCALDGASLPRARLLDSVLTGVRGVGT
                     DLAEATLRDVELHDARLGGTQLHGAVLERVLVRGGKIDYLNLRRSRLKDVVFEGCVLVE
                     PDFGGARLERVAFVDCALRQADLSAAVLTDVDLRGAAPLELSRGVDRLSGAVISPPQLL
                     DLAPVLAAELGLRVVGEEE"
     gene            6544..7704
                     /locus_tag="EZV63_RS15245"
                     /old_locus_tag="EZV63_15425"
     CDS             6544..7704
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974708.1"
                     /locus_tag="EZV63_RS15245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15425"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_166624335.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.6e-06, bitscore:
                     26.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRITVVGGGFAGLTAAVTAAEAGAKVTVYEAHHTLGGRARTSEG
                     PYRTNDGPHALYRGGPHWSWLAQRDLIGPLAPLPVREAARLRLRYRGVLRRTPPLAMLR
                     LLRRGVGPAPVDADFLTWASRVAGEEGARAAAHYCAVALFHHDPGSLSAAFVQERLRRA
                     AKLPPEARYPRGGWQGVVDRMAARAWNLGVRVETLSRVDTLPTDTPVVVATSLDAARRL
                     LNDPALTWPSGRTALVDLAVRTRRGDAFAVSDLDAPGWIERFSTQDRTLAPAGEQLIQG
                     QVPIAPHESKADGVARAEDLLDLGFPGWRGRLTWRREAVANGRTGAVDPPGTTWRDRPA
                     VDRGDGVYLAGDQVAAPGLLSEVSFNSALTAVSLALGRRELDLRHA"
     gene            7877..9310
                     /locus_tag="EZV63_RS15250"
                     /old_locus_tag="EZV63_15430"
     CDS             7877..9310
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326673.1"
                     /locus_tag="EZV63_RS15250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15430"
                     /product="MFS transporter"
                     /protein_id="WP_037768103.1"
                     /transl_table=11
                     /translation="MVIALAQLMVVLDATIVNIALPSAQRDLDMSDGNRQWVITAYTLA
                     FGGLLLLGGRVSDLVGRKRTFVIGLVGFAAASAIGGAAANSMMLFGARALQGVFAAVLA
                     PSALSLLTTTFTDPRERGKAFGIYGALAGSGSAIGFIVGGVLTEYLNWRWCLYVNVPVA
                     VVAVIGALVLLHDRPGHAGARLDVPGVVLGCGGLVALVYGFSEAQPRGWTDALVLALFA
                     LALVLLAAFVWWQTRAPMPLLPLHIIRDRDRAGCFLTMMLAVIGMFGLFLFMTYYLQVI
                     LGYSPVRTGLAFLPMTVAIVVGSTQIAARLLPHVSPRTLMVPGMLLASGGMVILTQMTV
                     RSEYVSEILPALLLMGLGMGLTFMPVFSTATAGVAPRDSGVTSATVNTSQQVGGSIGTA
                     LLNTIATSTSASWITAHLTDPSQRELVVREGIVHGYTVAIWVAAGVMLLAGLVAGLMVT
                     AKAPKHGTPADRPVPEPVA"
     gene            complement(9327..9905)
                     /locus_tag="EZV63_RS15255"
                     /old_locus_tag="EZV63_15435"
     CDS             complement(9327..9905)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047604.1"
                     /locus_tag="EZV63_RS15255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15435"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_031038263.1"
                     /transl_table=11
                     /translation="MPEHRSRKDAARNREAVLAAADALFARRESAEDVTMADVAAEAGV
                     GKGTLFRAFGDRVGLLRALYEARLGPVRDAVESGPPPLGPATPPRERVPALLDAVLCFK
                     LDNRRLVVALEESGGGSSPYQASHYEWLHRLLRDVLEEIPGAPGSDFTAHALLAATRAD
                     LVEHLAGREGVPREALRAQLADFTAGLLD"
     gene            10001..10441
                     /locus_tag="EZV63_RS15260"
                     /old_locus_tag="EZV63_15440"
     CDS             10001..10441
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phenazine: phzB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980068.1"
                     /locus_tag="EZV63_RS15260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15440"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_031038266.1"
                     /sec_met_domain="phzB (E-value: 2.3e-23, bitscore: 81.4,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="PF07366 (E-value: 1.2e-05, bitscore: 23.8,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPAPNAPAAPAELFRHGLRLLLDKDMSAFAGLWAEDGVMEFPF
                     APDGWPRRLEGREAVAAYLRHYPDHIDLHDFTDVRIHETTDPQTVVAELRGEGRLVATG
                     APFAMTYVQVLTVRDGRIASCRDYWNPLGVQEPGADFTGSAR"
     gene            10438..11328
                     /locus_tag="EZV63_RS15265"
                     /old_locus_tag="EZV63_15445"
     CDS             10438..11328
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980067.1"
                     /locus_tag="EZV63_RS15265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15445"
                     /product="NmrA family NAD(P)-binding protein"
                     /protein_id="WP_224287202.1"
                     /transl_table=11
                     /translation="MTPAGTASIPDAASIPGTTLVVGATGTTGSRTAAGLTAAGHRVRA
                     AGRRAKPVAGAEPVAFDWYDPATHGAALDGVGRVYLVPPVGDTDPAAVMLPFLRRARAA
                     GVRRAVLLSSSAVPAGGPAVGAVHEALPGLFDEWAVLRPSWFMQNFTGTHAHARGIRDE
                     GVIRTAAEDGRVAFVDAEDIAAVAVRALTDARAPGTDLVLTGPEALSHDDVAAIATEVT
                     GRPVVHRRLSQEQLADHLTTEVPAPFAALLAGLDRAIAAGAEDRVTDTVRRVTGRPPRG
                     FRAHFEDARRSRPES"
     gene            11459..12340
                     /locus_tag="EZV63_RS15270"
                     /old_locus_tag="EZV63_15450"
     CDS             11459..12340
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /GO_process="GO:0019748 - secondary metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974711.1"
                     /locus_tag="EZV63_RS15270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15450"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_166624336.1"
                     /transl_table=11
                     /translation="MIEVPDGLVAAQVKYNGAAGRAFVDGLPELAAGFLERWGLRLDGP
                     SMHGWAALVLPVVCRDGVPAALKLQIRDEESEGEPLALRVWDGDGAVRLLDHDEATGTM
                     LLERLDQGRMLGHVEDSREAVLVIARLLAHLTATPAPPGMRRLGDIARGMLERTPRALE
                     RIADPADRRLVADCAAAVREVAAEPGDRLLHWDLHFENVLASGRAPWLAIDPKPLAGDP
                     GFDLLPALDNRYDPGETRWRFDAMTDVLGLDRERARAWSLGRVLQNCLWNVEDGDPLEV
                     EQLEIGRLLLGG"
     gene            complement(12347..15688)
                     /locus_tag="EZV63_RS15275"
                     /old_locus_tag="EZV63_15455"
     CDS             complement(12347..15688)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029541.1"
                     /locus_tag="EZV63_RS15275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15455"
                     /product="AAA family ATPase"
                     /protein_id="WP_166624337.1"
                     /transl_table=11
                     /translation="MTGPLRERDDADVLLAAETERALAGTGRLVLLRGASGTGRTAVLD
                     SAARGAADRGLRVLRARCSPDDTAVPFATVVQLLGPVPEFTEVASADDERGSAALLWRL
                     LRAYADEGPVLLAVDDVHLADDPSRRWLADAARRIDRLPVLLVATERSQYDVDPRPAGL
                     TQALSPSLVRTHTLAPLSDRAAAGLVRAAFPEACATWAAECVRAGAGSPLLLHALLDDL
                     GGTPHPDGLPPVPDTAASLYPGSYPAAVSWWLKSAGPVTAEVARSLAALEQAWPAAAPA
                     RRREHRHALPHPEARARGGGDTAPGCRDVWSAEHEGDGDGGGFAGRGGAVPGTPGAFPQ
                     APGATEPGSAAYGAQRPPYGTAAPDRGGPDPCAEPPGPHPHPADHPAGPGPGPGPGPGP
                     GPGPGPADVDAGRGSASWSSPWYPFPVPYGGRPGPAHGAAAPGRPGTPPYASPDRSARW
                     GAPAAPSPAAGEGAGDPVDVLAEAVGADPARIAGWLAAMTRLGLLRPDAGGRPRYAHPL
                     LRDAVLTGWPRPRREAVHRAAAQAMLRRGDRVEAVARHLLHTPAVRLPWALRVLRDAVT
                     VAVHDARPADAVAYLRRALDEPLSDVLRQRLLTELGSLEYASADTPAAIARLAEAQHLP
                     ADPRNRVRTAVALGTALAGRGEIRTAMEVLRRTEGRLADHPELARTVQTAGALLSDEDL
                     ATRQEVYRGLSETGRHSPELVGTAGQALLVRYAASAALISADEAMARIRDLLAQPGDPL
                     AEPFLLGTAAAVAQWADELDEADRLVERGLAGQHPALLHPMQHALLNTRADIAAARGDH
                     ARLLAPVGRGPGTGPTNQDAHALMALVHTGRTHEALRFADRFDLREMPENWERNRYLYA
                     RGVLRAATGDPAGALHDFLECGRRQGAREVVSPVVTPWRTAVAECRLALGGGPEALALA
                     TEELRLARVWNTPRTVGRALRVLGSATGGRRGLELTEEAVRTLRDAPADTDMELIPALL
                     AQGRLLLATGERGRARARLREAAELAERKGALRWLTQADQALRVGGARRSVAARTGAGA
                     LTGSERRIAELAADGRTNTEIADLLHLARRTVETHLTSTYRKLRIRRRTELPGALRHGA
                     HPNPQS"
     misc_feature    complement(15263..15265)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15982..15997)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            16142..16795
                     /locus_tag="EZV63_RS15280"
                     /old_locus_tag="EZV63_15465"
     CDS             16142..16795
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922987.1"
                     /locus_tag="EZV63_RS15280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15465"
                     /product="response regulator transcription factor"
                     /protein_id="WP_051159771.1"
                     /transl_table=11
                     /translation="MSGVTDRTSGITDRRVPVAVTAPDPISREGAISQLRRHPEIDLRE
                     ETGPGTVALLIEDALDDAALTRLRRIVRSEGARAVLVTGAIRESELLDVVECGVGAIVW
                     RHEATAHRLVQAVLAASRGDGDLPADLLGRLISQVGTLHRGAAGRPGAPSLGLAPREVD
                     VLRLVAEGLDTGEIAGKLSYSERTVKNVMHGLTTRLHLRNRAHAVAYALREGYI"
     misc_feature    complement(16796..16811)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.91"
                     /tool="antismash"
     gene            16968..17645
                     /locus_tag="EZV63_RS15285"
                     /old_locus_tag="EZV63_15470"
     CDS             16968..17645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019984834.1"
                     /locus_tag="EZV63_RS15285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15470"
                     /product="DUF4255 domain-containing protein"
                     /protein_id="WP_070388402.1"
                     /transl_table=11
                     /translation="MIHEVDEVLKALLKGGALTGSGIDVAFEAPTRDWAARRNAPVVNT
                     YLYDIREDVNRRQRGQMAVRDEDAIIVKRRQPPRWFRLSYLVTAWTKTPQDEHRLLSAV
                     MATLLPRELLPPSELPGSLGALGLSIPLTVAGIQTEARSLAEIWSALGGELKPSLDLVV
                     TAPFPAFPEYDAGPPVTEGATVRVGGMDGDPPMAEGRSHRPHQVAAARAARRGQADRGT
                     GRL"
     gene            17768..19744
                     /locus_tag="EZV63_RS15290"
                     /old_locus_tag="EZV63_15475"
     CDS             17768..19744
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016435639.1"
                     /locus_tag="EZV63_RS15290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_15475"
                     /product="ATP-binding protein"
                     /protein_id="WP_228773894.1"
                     /transl_table=11
                     /translation="MLSARLSALHEPVATLVEQRAGTDPTADDPLRGLYLSDEAVQHLL
                     DSWPSDAEDAAPGHAPSGPVPDVPQADPADRLARLAARTNLTELDTAVLLIALAPDVDR
                     TFEPLYGYLNNDVSRRRASVSLALELCGVPAHLAAARGRFHASAPLLSLGLLELEDPER
                     PFLTRALRVPDRLIGHLLGDDTPDAALLGLLRPMPEALPATGTDDFVRQLAARLKEGPL
                     TAYLREPREGDGLAALASVLDAAGLDALRCAGAEDHVPELLREARLSGRAVVVPGLPEK
                     PAALVRALTAATDVTVLLTDPRPYDPHWAPDDPLVLDAPGRRAGGAAAWRAALGPDADG
                     FDLASAVAPYRLGGDRIQRAAHAALALAAFDGTPLSAEHVRLAARRQSASGLESHARRI
                     RPDVDWQDLVLPDKPLVQLRELALRARHRDRVLGDWRLSAGGGRGRGVLGLFAGESGTG
                     KTLSAEVVAADLGLDLYVVQLSSVVDKYVGETEKNLERIFTEADRTDAVLLFDEADAVF
                     GKRSEVKDAHDKYANMESAYLLQRLESFDGIALLTTNLRANIDEAFTRRLDLVVDFPFP
                     DPDQRLALWRHCLSRVPSAEDIDPEPLARKFELAGGSIRSAVVTAAYLAAGRDDTVTAD
                     DLLEGARREYRKAGRLVPGEGGW"
ORIGIN
        1 cggtcggagc gcgccaggta cacccggccc atgccgcctt cgccgagtct gccgagcagc
       61 cggtacctgc cgatccgttc gggatcgccc ggtatcaacc cgtccatgct tgctccctct
      121 cccccggcga caccgtgcgc accgggatta cgcacgagga tagggacagg aggtgcctgt
      181 ggaaaacccg gtacgcccgg ggcggttggg gcgttcgtcc actcccggcc acggatgcgg
      241 tgaacgccct cccgcatccg ccccgggtgc gtcccggcgt ccgcggcacc ctccgcgtcc
      301 gcgtccggcc ccgcgtccgt gacaccatcg ccgcgtgctc gacatcggct acgccctctc
      361 cacccgcttc cccgacccgc cccagacgga ctaccgccgc gcggacgtcc gtgccctgcg
      421 gcacgacctg ttctgcgggg acgtgtacct cgccgacacc gaggcggacc gggaactgtc
      481 cacagcctgg ggatgggtgc cggtgctcga cttcgcgtgg gcgctgtgcg acatcgcgga
      541 gcgcgtcgac cgggacccgg cgggctcccg ggcggcccgg ccgcagcggg cggaactgga
      601 cttcaccgag tccgccgacc gcctgctctt cgagcgccgc ttcggctggg tcgacatcga
      661 ggcggagtgg ctgccggcct ccgagccccc gctctccttc tcccacgccg aactccgccg
      721 cgaggcccgc gacttcctcc aggacctgct cgccgacctc acggacctcc acgaggacct
      781 gtccgacaac ccggcggtct ggaccctgca ggcccgcttt ccgcggatcg cgtgacggcc
      841 ccggcccggc cccggccggc gactgccgcc tgcgtgtcgg ccccgctcgg cagcgatgct
      901 tgaattggac cgttgttcct gatccagcaa ggagatgtgc cgtgcccctg gtgtctgtcg
      961 tgatgcccgt gtacaactcg gccgccaccc tcggcgcggc cgtccggtcg gtactcacgc
     1021 agacccacgg cgacctggag ctactggtca ccgacgatca gtcctccgac ggctccatgg
     1081 acctgctgcg cgagttcgcc gcccgggacg agcgggtcct gccggagagc gcacccgagc
     1141 ggggcggtgc gggccgggcc cgcaacctcg ccatcgagcg ggcccgcggg gactacatcg
     1201 ccttcctgga ctcggacgac atgtggctgc cggagaagac cgagaagcag ctcgccttcg
     1261 ccgcggaagg ccgcgcgccg ctgacgttca cctcgtactt caagatggac gccgactacg
     1321 acggcgagag caccgactgg gtcccgaacg gccgggtgat ccgtgcgcgg gagcacgtgg
     1381 actaccgcgc catgctggtc caggaccaca tcggtgctct caccgccatg tacgaccaca
     1441 aggccctggg cacgaggctg atgccggaga tgcgcaagcg ccaggactac gccctgtggc
     1501 tgtcgatcat gcgggacggc gccgacgccc gcgggctggc cgagccgctc gcggtgtaca
     1561 gggcgaacca ggcggggtcg ctgtcctcca acaagctctc gctggtgcag tacaactggg
     1621 ccctgtaccg cgagcacgag cacctgtcgg tcccgcgggc gacgcgcgca ctggccggcg
     1681 ccgcgtggca gtcgctgcgc aactcgcgcg tctaggcggt gcctccgcgc gtcacctgcg
     1741 cgcgaacgga atccgcgggc ggtgatgccg cccgggtggg cggacgagcg gcccggctca
     1801 gtggccgatg acgaccttcc cgaagcgcgg tccccgctcg aagtgggcga acgcctcgga
     1861 tgcctggtcg aaggggaaga cacggtcgat gacgggccgg agcgtgcttc ggtcgagggc
     1921 ctcgttcatc tgctcgaagt cgctgcggct gcccacgctg atcgacctga gggtcgcggc
     1981 ccggcggaag aagtgggtca cgtccatgtc gttgcccgac gcgaggttgc cgaccagggc
     2041 gatctggccg ccgtgggcga cggcctcgac ggactgcggg agggtaccgg cgccgccgat
     2101 ctccaggacg cgttccacgc cgccgccggt gagctcccgc acccgcgcgc cccatcgcgg
     2161 tgtctcccgg tagttgacga cgtcggccgc accgagcgcg cggaggcgct cggccttgtc
     2221 gtcgtcggac gtcgtggcca ccacacgtgc gccggccagg cgggcgaact gcaacgcgaa
     2281 gaccgacaca ccgcccgagc cctggacgag cagggtgtcg cccggcccga ccccggccac
     2341 cgccgaccac gcggtgagcg cggcgcacgg cagcgtggcc gcctcctcga aggagagccg
     2401 gtcggggatg cggaccaggc tctgctggtc gaggacgacg tgatcgctga gccacccgtc
     2461 gcgctgcgtg ccgcgcagcg ccccccatcc ggggaacggg ccgtacaccc aggtgggatg
     2521 gaaggtgccc gcgacccggt cgccgacccg gaaccgcgag accccgtccc cgacggcctc
     2581 gacgacgccc gcgccgtcgg agagcggaac gcgtccccgt acgtcgacgg agtagctgtc
     2641 ggagacgatg agccgatcgc gggcgttgag cgaggtggcc ctgaccttca ccagcacctc
     2701 acccgccgac ggatcgggta ccgggcggtc ggtggtgagc gtcaggccac cacccgcccg
     2761 caccgtgaat gcacgcatgc gcggcctctc tttcgtgaac tcccgccacg gtaggctgac
     2821 agttctggac gatcggcatc tttccgtcca gaatctggtg cagagcgtcc aggaggttcc
     2881 gtggatccgg tcgacgacct cctcaccacg atgaggatcg aggacgcgcg atatgtccga
     2941 gtggaagcga acgcgccgtg gggcatctcg ttccccccac ggcacctggc ccggctgatc
     3001 ctcatctccg acggctcgtg ccggctcgac tcggacgtcc tggaccggcc gcagcgcctg
     3061 gagtcgaacg actgcttcct ggtccgcgcg ggcgtgggct tcaccctgcg ggacgcggac
     3121 gacagcgaga tcctcgactg cgacgacctg gcggctcagg catccggtca cctggtacga
     3181 gtcggagggg acggcgagcc gacccggatc ctctccactc gcttcacctt cgacgccgtc
     3241 gccgccgaac cgctcttcgc acttctgccg cccttgttcc ggctgccccc ggacgacgcc
     3301 tccggcgagc tgctgcgtgc cacgttcgag ctcatcgagc acgagagctc ggcccgtcgg
     3361 ctcggcgccg gattcgtcat gggccgtctg tccgacgcgc tcttcgtcca ggccctgcgc
     3421 acctgctgcg cggacgtcgg gagcggcagt gtcggctggg tcgccgctct ccgggatccc
     3481 cgactggccc tcgccatgca ggagttgcac gccgatctga gccgctcgtg gacggtcggc
     3541 gagctggccc gaaccgcggg gatgtcccgc tcggcgttcg ccaccctgtt cagggaacgg
     3601 acgggcgaca ccccgctgag ctacctcacg gcatggcgca tgtaccgggt gaaagtcctg
     3661 ctccgagaga ccccgctgag cgttcaggag atcgccgtca gggtcggcta cgacaccggc
     3721 accgccctga gccgggcctt ctcgaagcgg gaaggcgtct cgcccggaac ctggaggaag
     3781 acggcccggg gagcggatcg ccaggagccg tcttcgccga ggcaggcata gaaaagacca
     3841 atacaggtca tgcagtgagg ctatttttct ctatggccaa tcggtcatac cgtggtccgt
     3901 acccagggca gccgccggga caggaagacc gcggagcagc ggtctttctc cgccgatcgg
     3961 caagtcccgc ggtgccggtc gcgcgaagag gattcggcag agtcccgcgt ccggtgccga
     4021 ctgcctcgac cgaaggagaa agctgtgcgt ctcacgaaca aggtggccct cgtcacgggc
     4081 ggaagcgcgg gactcgggct ggcgatcgct cggagattcg ccgcggaagg cgcccacgtt
     4141 tacatcacgg gacggcggaa agaggcactc gacgcagcga aagcctccat cgagggacgt
     4201 gtcaccgcgg tcgccgcgga cgccaccgac tcgggtgatc tcgacgatct ggtcgaggcc
     4261 atccgtcggg agagcgggca cctcgacgta ctcgtcgcga atgcgggcag catcgagcgg
     4321 atgaacttcg gcgaggtgac cgaggaacac ttcgaccgca ccttcgatct caacgcccgc
     4381 ggcacgctgt tcacggtcca gaaggcactg ccgcttctac gagcgggcgc ctcgatcgtt
     4441 ctgctgggtt cgatcacggc gttcaagggg gacccggggg cgggtactta cagtgcggcg
     4501 aaagccgccg tgcgctctta tgcgcgcacc tgggcggcgg aattcgccga ccgggggctc
     4561 cgggtcaacg tgctgagtcc cgggccgatc gacacgctca tcatcgacgg acaggccgag
     4621 tacttcgggc aggaccccgc gaccgtccgg gcccggatga gcaccctcgt cccgatgggg
     4681 cgcctcgggc tccccgagga gatcgcccat ggagcgctgt tcctcgcctc ggacgagagc
     4741 agcttcatga cgggcgcgga gctctgcatc gacggcggca tggcccaggt atgacctcct
     4801 ctccccgcac acaccgccac gcgtggcatg aaacaccgga aggtgcctga tgaggttttt
     4861 ggccgtccac ggcggctgcc acggagcatg ggcctgggat ttcgtgaagc ccgaaatggt
     4921 caagctgggc cacgagctgg tttcggtgga acttcccggt catggcagca gactcagcga
     4981 aacagccaca ctcgacggct atcgcgaggc tgtcgtcgaa ctcatggaac ccggcgacgt
     5041 actcgtcgga cattcctccg gatctgtggt cgccatcctt gccgcgaacg agcggccgga
     5101 tctggtttca catctctgcc tggtggccgg cattcttccc gtcgagggaa tgccgctttc
     5161 cttcgagagg gagtcggcca accccgggtc cggtgaagac ccgcacggcg gaaacggtgc
     5221 ggcgctggag acctacatgc ggatgaccga agacaatgag gcgttctact tcgaacgctc
     5281 cggcgcggtt tcggcgttct acaacgactg ctccgaagac ctcatcgact ggattttccc
     5341 gaagctcgtt cccgagccgt tggcgcctct ggcagtcccc atatcggtcc cgaacttctg
     5401 ggcgcagcac gacctctcgc gcagtttcat catgggctcg cgggacacga tctgctttcc
     5461 cgagctggcg cgtctgcagg cgaggcgcct cggggtggtc ccgctggaga tcgacgcagg
     5521 gcactcgccc tggctgagcc ggccggccga attcgcgagc ctcttggtcg cggcgacgag
     5581 aaccaagccc gtcggaccac ttgttccgac ctccttgcac gccatgcccg aacaggccgg
     5641 ctgagcgcaa cgggattcgt cgacagctcg ggagacctac tactcctcct cccccaccac
     5701 ccgcagcccc agctccgccg ccagcaccgg ggcgaggtcg aggagttggg gcgggctgat
     5761 caccgcgccc gagaggcggt cgacgccgcg ggagagttcg agcggggccg cgccgcgcag
     5821 gtcgacgtcg gtgaggacgg ccgcgctgag gtccgcctgc cgcagggcgc agtcgacgaa
     5881 cgcgacccgc tccaggcggg cgcccccgaa gtccggctcg accaggacgc agccctcgaa
     5941 gacgacgtcc ttgaggcggg accggcgcag gttcaggtag tcgatcttgc cgccgcggac
     6001 caggacccgt tccagtacgg cgccgtgcag ctgggtgccg cccaggcggg cgtcgtgcag
     6061 ctcgacgtcg cgcagggtcg cctccgccag gtcggtgccc acgccccgga cgccggtgag
     6121 gaccgagtcg agcagccggg cccggggcag cgacgccccg tccagcgcgc agcccgtcag
     6181 cgcgcagtcc atgaagcggg cccccgcggc gtcctggccg gacaggtccg tctcccggaa
     6241 ctccagcgcg tcgtagtccc cgtccggttc gagtccgccg tcctcgtacg gcgtgagcgg
     6301 gggcagccgc agctccgggc gccgtgccgc ccgcaccttc gccgctcccg cgcccgtgcc
     6361 cctgcttctg ccggtaccgc cgccggccgc cgctctcctc gccatgcccc catgctgcac
     6421 cccgccactg acaacccggc cgacctgcgc gaacgcccgg tcaccggcgc cgtgtcacat
     6481 ttcgcaggcc ctcggacgtc gtactggcga caggcgaccc cgacccgagg gagaccccga
     6541 gccatgcatc gcatcaccgt cgtcggcggc ggcttcgccg gactgaccgc cgccgtcacc
     6601 gccgccgagg cgggcgccaa ggtcaccgtg tacgaggccc accacacact cggcggccgc
     6661 gcccggacgt ccgaaggccc ctaccggacc aacgacggcc cgcatgccct ctaccggggc
     6721 ggcccgcact ggtcgtggct cgcgcagcgc gacctgatcg gaccgctcgc gcccctcccg
     6781 gtacgggagg ccgcgcggct gcggctgcgg taccggggcg tgctgcgccg caccccgccc
     6841 ctggccatgc tcaggctgct gcgccggggc gtcggaccgg cgccggtcga cgccgacttc
     6901 ctgacctggg cgagtcgggt cgcgggcgag gagggcgccc gggccgccgc ccactactgc
     6961 gccgtcgccc tgttccacca cgatcccggt tcgctgtcgg ccgcgttcgt gcaggagcgg
     7021 ctgcgccggg ccgccaagct gccgcccgag gcgcgctacc cgcgcggcgg ctggcagggg
     7081 gtcgtggacc ggatggccgc cagggcctgg aacctcgggg tacgggtcga gaccctgtcc
     7141 cgcgtcgaca cgctgcccac cgacaccccc gtcgtcgtcg ccacctccct cgacgcggcc
     7201 cgccgcctgc tgaacgaccc cgcgctgacc tggccgagcg gccgtaccgc cctggtcgac
     7261 ctggccgtac ggacccggcg cggggacgcc ttcgcggtct ccgacctgga cgcgcccggc
     7321 tggatcgaga ggttctcgac gcaggaccgg acgctggcgc cggcgggcga gcagctgatc
     7381 caggggcagg tgccgatcgc gccccacgag tcgaaggccg acggcgtcgc ccgcgccgag
     7441 gacctgctcg acctcgggtt ccccggctgg cgggggcggc tgacctggcg gcgcgaggcg
     7501 gtggcgaacg gccgtaccgg cgccgtcgac ccgcccggca ccacctggcg cgaccggccg
     7561 gccgtcgacc ggggcgacgg ggtctacctg gccggtgacc aggtggccgc cccgggactc
     7621 ctctccgagg tctccttcaa cagcgccctg acggcggtct ccctcgccct cggccgcagg
     7681 gaactcgacc tcaggcacgc ctgaggacgt cgggcgggga cgtagggcgg aggacggcgg
     7741 atggaggacg tcgggcggag gacggcggcg ggatgcgata cgtcctgatt catggtcttc
     7801 tggcggggtg agttccaccc ggacaggtga cccggccgcg cccggcgaag ccgatccccg
     7861 ccgctggtgg gggctggtgg tgatcgccct ggcccagctg atggtcgtcc tcgacgcgac
     7921 gatcgtgaac atcgcgctgc cctccgcgca gcgcgacctg gacatgtccg acggcaaccg
     7981 ccagtgggtg atcaccgctt acaccctcgc gttcggcggg ctcctgctgc tcggcggccg
     8041 ggtctcggac ctcgtggggc gcaaacgcac gttcgtcatc gggctggtcg gcttcgccgc
     8101 cgcgtccgcg atcggcggtg ccgcggccaa ctcgatgatg ctcttcggcg cccgcgccct
     8161 ccagggcgtg ttcgccgccg tgctcgcgcc gtccgcgctg tccctgctga cgaccacctt
     8221 caccgacccg agggagcgcg ggaaggcgtt cggcatctac ggcgcgctgg ccggcagcgg
     8281 ctccgcgatc ggcttcatcg tcggcggcgt gctcaccgag tacctgaact ggcgctggtg
     8341 cctgtacgtc aacgtccccg tcgccgtcgt cgccgtgatc ggcgccctcg tgctgctgca
     8401 cgaccggccg ggccacgccg gcgcccgcct cgacgtgccc ggtgtggtcc tgggctgcgg
     8461 cggcctggtc gcgctcgtct acggcttcag cgaggcgcag ccccgcggct ggaccgacgc
     8521 gctggtcctc gcgctgttcg cgctggccct ggtcctgctg gccgccttcg tgtggtggca
     8581 gacccgcgca ccgatgccgc tgctgccgct gcacatcatc cgcgaccgcg accgcgccgg
     8641 ctgcttcctg acgatgatgc tggcggtcat cggcatgttc gggctgttcc tcttcatgac
     8701 gtactacctc caggtcatcc tcggctactc gccggtgcgc accgggctgg cgttcctgcc
     8761 gatgaccgtc gcgatcgtcg tcggctccac ccagatcgcg gcccggctgc tgccgcacgt
     8821 gagcccgcgg acgctgatgg tgccggggat gctgctggcc tccggcggca tggtgatcct
     8881 cacgcagatg accgtgcgct cggagtacgt ctcggagatc ctgcccgcgc tgctgctgat
     8941 ggggctcggc atgggcctga ccttcatgcc ggtcttctcc acggccaccg ccggggtcgc
     9001 cccgcgggac tccggggtga cctccgcgac cgtcaacacc tcgcagcagg tgggcggctc
     9061 catcggtacg gcgctgctca acaccatcgc gaccagcacc agcgcgtcct ggatcaccgc
     9121 ccatctcacc gacccctccc agcgcgagct ggtcgtgcgg gagggcatcg tccacggcta
     9181 cacggtcgcc atctgggtgg ccgcgggcgt catgctcctc gcgggcctgg tcgcgggcct
     9241 gatggtgacg gccaaggctc ccaagcacgg caccccggcc gaccgcccgg tgccggaacc
     9301 ggtggcctga gggcaccgcg gcacggtcag tccaggagcc cggcggtgaa gtcggccagc
     9361 tgcgcccgca gggcctcccg cggcacgccc tccctgcccg ccaggtgctc gaccaggtcg
     9421 gcccgcgtgg cggcgagcag ggcgtgggcg gtgaagtcgc tgccgggcgc gccgggaatc
     9481 tcctccagca cgtcccggag cagccggtgc agccactcgt agtgcgacgc ctggtacggg
     9541 ctgctcccgc ccccgctctc ctccagggcc accacgaggc gccggttgtc gagcttgaag
     9601 cacaggacgg cgtcgagcag ggcggggacg cgctcccgcg gcggcgtcgc gggccccagg
     9661 ggcggcggcc ccgactcgac ggcgtccctg accggcccga gccgtgcctc gtacagcgcc
     9721 cggagcagcc cgacgcggtc gccgaaggcc cggaagagcg tgcccttgcc gaccccggcc
     9781 tccgccgcga cgtcggccat ggtgacgtcc tcggcgctct cgcgccgggc gaagagggcg
     9841 tcggcggcgg cgaggacggc ctcccggttg cgcgcggcgt ccttgcggga cctgtgctcc
     9901 ggcatgctgc tctccttcct ccctttacaa aacggacccg cagtccgtat cgtctatcga
     9961 aacggacccg aggtccgtat tctacgactg gaggataccc gtgtccgcac ccgcaccgaa
    10021 cgcgccggcc gccccggcgg agctgttccg ccacggcctg cgcctgctgc tcgacaagga
    10081 catgtccgcg ttcgccgggc tgtgggccga ggacggggtc atggagttcc ccttcgcccc
    10141 cgacggctgg ccccggcgcc tggagggcag ggaggccgtc gcggcgtacc tgcgccacta
    10201 ccccgaccac atcgacctgc acgacttcac cgacgtgcgg atccacgaga cgaccgatcc
    10261 gcagaccgtc gtggccgaac tgcgcggcga gggccgcctg gtggcgaccg gcgctccctt
    10321 cgccatgacg tacgtccagg tcctgaccgt ccgggacggg cgcatcgcct cctgccgcga
    10381 ctactggaac ccgctcggcg tccaggagcc cggcgccgac ttcaccggga gcgcccggtg
    10441 acccccgccg gcaccgcatc gatccccgac gccgcatcga tccccggcac caccctggtc
    10501 gtcggcgcca ccggcaccac cggaagccgc accgccgcgg ggctgacggc cgccgggcac
    10561 cgggtcaggg ccgccggccg ccgggcgaag ccggtcgccg gcgccgaacc ggtcgccttc
    10621 gactggtacg acccggccac ccacggggcc gccctcgacg gcgtcggccg cgtctacctc
    10681 gtgccgcccg tgggcgacac cgaccccgcg gccgtcatgc tgccgttcct gcggcgggcc
    10741 cgcgccgcgg gcgtgcgccg cgcggtgctg ctgagttcct cggccgtccc ggcgggcggc
    10801 ccggcggtgg gcgcggtgca cgaggccctg cccggcctgt tcgacgagtg ggcggtcctg
    10861 cggccctcgt ggttcatgca gaacttcacc ggcacgcacg cgcacgcccg cggcatccgc
    10921 gacgagggcg tcatccgcac cgccgccgag gacggccggg tcgccttcgt cgacgcggag
    10981 gacatcgccg ccgtcgccgt gcgcgccctg accgacgccc gggcccccgg caccgacctc
    11041 gtcctcaccg ggcccgaggc gctcagccac gacgacgtcg ccgcgatcgc caccgaggtc
    11101 accggccggc cggtggtcca ccgcaggctg tcccaggagc agttggccga ccacctcacg
    11161 acggaggtcc cggccccgtt cgccgcgctg ctggccggac tggaccgggc catcgccgcg
    11221 ggggcggagg accgcgtcac cgacaccgtc cggcgcgtca ccggccggcc gccgcgcggc
    11281 ttccgggcgc acttcgagga cgcccggcgg tcccggccgg agtcctgacg cagcacggcc
    11341 gccacgcggc acagcggcca cgcggcgggg tgggacgggg gcacccggat atcccgcgtc
    11401 gcgccgcgcg ggatatccgg gtgcccccgt cccccccgcc ccggtaccgt cggtccgcat
    11461 gatcgaggtt ccggacgggc tcgtggccgc gcaggtgaag tacaacggcg ccgcggggcg
    11521 ggcgttcgtc gacgggctgc cggagctggc ggccgggttc ctggaacggt gggggctgcg
    11581 gctcgacggg ccgtcgatgc acgggtgggc ggcgctggtg ctgccggtcg tgtgccgcga
    11641 cggcgttccg gccgcgctga agctccagat ccgcgacgag gagagcgagg gcgagccgct
    11701 cgccctgcgg gtgtgggacg gggacggggc ggtgcggctg ctcgaccacg acgaggccac
    11761 cggcaccatg ctcctcgaac ggctggacca gggccgcatg ctcgggcacg tcgaggactc
    11821 ccgcgaggcc gtgctcgtca tcgcccggct gctcgcccac ctcaccgcga ccccggcacc
    11881 acccggcatg cgccgcctcg gggacatcgc gcgggggatg ctggagcgca cgccccgggc
    11941 gctggagcgg atcgcggacc cggcggaccg gcggctggtc gccgactgcg ccgccgccgt
    12001 gcgcgaggtc gccgccgagc ccggcgaccg gctgctccac tgggacctgc acttcgagaa
    12061 cgtcctcgcc tccgggcggg cgccctggct cgccatcgat cccaagccgc tggccggtga
    12121 ccccggcttc gacctgctgc ccgcgctgga caaccggtac gacccgggcg agacgcggtg
    12181 gcgcttcgac gccatgaccg acgtgctcgg actcgaccgg gagcgcgccc gcgcctggtc
    12241 cctcgggcgg gtcctgcaga actgcctgtg gaacgtcgag gacggcgacc cgctggaggt
    12301 ggagcagctg gagatcgggc ggctgctgct cggcggctga gccgcctcag ctctgcgggt
    12361 tggggtgggc gccgtgccgc agcgctcccg gcagttccgt tctgcggcgt atccgcagct
    12421 tgcggtaggt gctggtcagg tgggtctcca cggtgcggcg ggccaggtgc agcaggtcgg
    12481 ctatctcggt gttggtgcgt ccgtcggcgg cgagttcggc gatccggcgc tcgctgccgg
    12541 tcagcgctcc ggcgcccgtg cgggcggcca cggaacgccg ggcaccgccc acgcgcagcg
    12601 cctggtcggc ctgggtgagc cagcgcaggg cgcccttgcg ttcggcgagt tccgccgcct
    12661 cgcgcaaccg ggcccgggcg cgcccgcgtt cgcccgtggc gaggagcagg cgcccctggg
    12721 cgagcagcgc ggggatcagc tccatgtcgg tgtcggcggg cgcgtcgcgc agggtccgta
    12781 cggcctcctc ggtcagctcc aggccgcggc gcccgccggt cgcgctgccg agtacgcgca
    12841 gggcgcggcc gacggtgcgc ggggtgttcc acaccctggc cagccgcagt tcctccgtcg
    12901 ccagggccag cgcctccggg ccgccgccca gcgccagccg gcactcggcg accgccgtcc
    12961 gccacggggt gacgaccggg ctgacgacct cgcgggcccc ctggcgccgc ccgcactcca
    13021 ggaagtcgtg cagggccccc gccgggtcgc cggtggcggc gcgcaggacg ccccgcgcgt
    13081 acaggtagcg gttccgttcc cagttctccg gcatctcccg caggtcgaac cggtcggcga
    13141 agcgcagcgc ctcgtgggtg cggcccgtgt ggaccagggc catcagggcg tgggcgtcct
    13201 ggttggtggg accggtgccg ggtccgcggc cgacgggggc gagcaggcgg gcgtggtcgc
    13261 cgcgggcggc ggcgatgtcg gcgcgggtgt tgagcagcgc gtgctgcatc gggtgcagca
    13321 gggcggggtg ctgcccggcc aggccgcgtt ccacgagccg gtcggcctcg tcgagttcgt
    13381 cggcccactg ggcgacggcg gccgccgtgc ctagcaggaa gggctcggcc agcgggtcgc
    13441 cgggctgcgc gagcaggtcc cgtatccgcg ccatcgcctc gtcggcggag atcagcgcgg
    13501 ccgaggccgc gtaccgcacc agcagcgcct gcccggcggt gccgaccagt tccggggagt
    13561 gccggccggt ctcggacagc ccccggtaca cctcctgccg ggtggcgagg tcctcgtcgg
    13621 agagcagcgc gccggcggtc tgcacggtac gggccagttc cgggtggtcg gccagccggc
    13681 cctccgtgcg gcgcagcacc tccatcgccg tgcggatctc gccgcggccg gccagggcgg
    13741 tgccgagggc gacggccgtg cgcacccggt tgcgggggtc ggccggcagg tgctgggcct
    13801 cggccaggcg ggcgatggcg gcgggcgtgt ccgccgacgc gtactccagg gagcccagtt
    13861 cggtcagcag ccgctggcgc aggacgtcgg agagcggctc gtccagggcc cggcgcagat
    13921 aggcgacggc gtccgcgggc cgggcgtcgt gcacagcgac cgtcaccgcg tcccgcagga
    13981 cgcgcagggc ccagggcaga cggacggccg gggtgtgcag caggtgccgg gcgaccgcct
    14041 cgacccggtc gccgcgccgc agcatcgcct gggccgccgc ccggtgcacg gcctcccggc
    14101 gcggccgggg ccagccggtg agcacggcgt cgcggagcag cgggtgggcg tagcgcggcc
    14161 ggccgcccgc atcggggcgc agcaggccga gccgcgtcat ggcggccagc cagccggcga
    14221 tccgcgcggg gtcggccccg accgcctcgg ccagcacgtc caccgggtcc ccggccccct
    14281 cgcccgccgc cggggagggg gccgcggggg cgccccaccg cgccgaccgg tccggcgacg
    14341 cgtacggggg cgtccccgga cgtccggggg cggccgcgcc gtgcgccggg ccgggccggc
    14401 cgccgtacgg gacggggaac gggtaccacg gggacgacca actcgccgag ccccgccccg
    14461 cgtccacgtc cgcgggtccg ggtccgggtc cgggtccggg tccgggtccg ggtccgggtc
    14521 cgggtccggc gggatggtcc gccgggtgcg gatgcgggcc cgggggctcc gcgcacgggt
    14581 ccgggcctcc gcggtccggg gccgccgtcc cgtacggcgg gcgctgcgcc ccgtacgccg
    14641 cgctccccgg ctccgtcgcg cccggggcct gcgggaacgc gcccggggtg ccgggaacgg
    14701 cgccccctcg tcccgcgaag ccgcccccgt ccccgtcccc ctcgtgctcc gcgctccaga
    14761 cgtcccggca gcccggggcg gtgtccccgc ccccgcgcgc acgcgcctcc gggtgcggga
    14821 gggcatgccg gtgctcgcgc cggcgggccg gcgcggccgc gggccaggcc tgctccaggg
    14881 cggcgaggct gcgcgccacc tcggccgtga cggggcccgc gctcttcagc caccaggaga
    14941 cggcggccgg ataggacccg gggtacagcg acgccgcggt gtccggcacc ggcggcaggc
    15001 cgtcggggtg cggggtgccg ccgaggtcgt ccagcagggc gtgcaggagc agcgggctgc
    15061 ccgcgccggc ccgtacgcac tcggcggccc acgtcgcgca cgcctcgggg aaggcggcgc
    15121 ggaccagccc ggccgccgcc cggtcgctca gcggggcgag ggtgtgggtg cgcacgaggg
    15181 acggggacag cgcctgggtg agtccggcgg gcctcgggtc gacgtcgtac tggctgcgct
    15241 cggtggcgac caggagtacc ggtaatcggt cgatgcgccg ggccgcgtcc gccagccagc
    15301 gccgggaggg atcgtcggcg aggtggacgt cgtccacggc cagcagcacc gggccctcgt
    15361 ccgcgtaggc gcgcagcagc cgccacagca gggcggcgct gccccgttcg tcgtccgcgg
    15421 aggcgacctc cgtgaactcc ggcaccgggc cgagcaactg gaccaccgtg gcgaagggga
    15481 cggcggtgtc gtcgggggag cagcgcgccc gcagcacccg cagcccgcgg tccgcggcac
    15541 cccgggcggc cgagtccagc acggcggtac ggccggtgcc gctggcgccg cgcagcagga
    15601 ccaggcggcc ggtgccggcc agggcgcgct ccgtctcggc cgccaacagc acatcggcat
    15661 cgtcgcgttc ccggagcggt ccggtcatcg gtgcctcctg tggtggatgg tgctcccccg
    15721 ggatggtgct ccccggtgtg tgagatgcgt aatggcgcgg atgggctgca tgaaagggcc
    15781 cggctttggg aaaatccttc cggtggcgga cggcggctgt ggcggggctc acggtggtgc
    15841 gcggccgttc ccgcgggtcc gtgactctcg gcaggcaccc tcctgacctg ccggaacacc
    15901 gaccggccag ccgctcgttg ctgccgtcgc gccggtctcg tggtgtgcct cgtggtggtc
    15961 cacgattgcg aagtcccagc agtcacagaa gtgtggaaca cgcacatccg ctactggcct
    16021 gtgccaggca acgggctcgt gaacaggggg gaaacggttg ctcaactcac cccggaccac
    16081 cacatcgtcc gtccgtgaat ccggtacgcc catcggtacg tccgtccgcg actccggccg
    16141 gatctccggc gtcaccgacc ggacctctgg catcaccgac cggcgcgttc cggtggcggt
    16201 caccgcaccg gacccgatca gccgcgaggg cgcgatcagc cagttgcgca gacatccgga
    16261 gatcgacctc cgcgaggaga ccgggcccgg cacggtggcc ctgctcatcg aggacgcgct
    16321 cgacgacgcc gccctgaccc ggctgcgccg gatcgtgcgc agcgagggtg cccgcgccgt
    16381 gctcgtgacc ggcgcgatcc gcgagagcga actgctcgac gtggtcgagt gcggcgtcgg
    16441 tgccatcgtc tggcggcacg aggccaccgc gcaccggctg gtgcaggcgg tgctggccgc
    16501 ctcccgcggc gacggcgacc tgcccgcgga cctgctcggc cggctcatca gccaggtggg
    16561 cacgctgcac cgcggcgcgg caggccgtcc gggcgccccc tcgctgggtc tcgcgccccg
    16621 ggaggtggac gtcctccgcc tcgtggccga gggcctcgac accggggaga tcgctggcaa
    16681 gttgtcctac tccgaacgca ccgtcaagaa cgtcatgcac ggactcacca ctcgactcca
    16741 tctgcgcaat cgcgcgcacg cagtggccta tgccctccgg gaaggctaca tctgaccgaa
    16801 cgggcaatcg agagcggacc cccggggccg caagggcagg ttcccctgcc cgaccgccgt
    16861 ccccgacgcg cctgcgggcc gggcggcacc cggggcacga tcggtgacag gcggcggcca
    16921 cgggcgggcc ggccggactc aagtgcgggc agagcgggag cgcgagcgtg atccacgagg
    16981 tggacgaggt cctcaaggcc ctcctcaagg gaggggcgtt gacgggctcg ggcatcgacg
    17041 tggccttcga ggcacccacc cgggactggg ccgcccggcg caacgccccc gtggtcaaca
    17101 cctacctgta cgacatccgc gaggacgtga accggcgtca gcgcggccag atggccgtgc
    17161 gcgacgagga cgccatcatc gtcaagcgcc gccagccgcc gcgctggttc cggctctcct
    17221 acctcgtgac cgcctggacg aagacccccc aggacgaaca ccggctgctg tccgccgtga
    17281 tggcgacgct gctgccgcgc gagctgctgc ccccctccga actccccggc tcgctgggcg
    17341 ccctcggcct gtccattccg ctgacggtgg ccggcatcca gaccgaggcc cgctcgctgg
    17401 ccgagatctg gtccgccctg ggcggcgaac tcaagccgtc cctcgacctg gtggtgaccg
    17461 cgcccttccc ggccttcccg gagtacgacg ccggtccccc ggtcaccgag ggcgcgacgg
    17521 tccgggtggg cggcatggac ggcgacccgc cgatggccga gggacgctcg caccggccgc
    17581 accaggtggc ggcggcccgt gccgcccgcc ggggccaggc ggaccgcggc acggggcggc
    17641 tgtgaacgcc ttccccaccg atccaccggg tcccacgacc gacggccccg cctccgaccg
    17701 gtcccaccgc ccggcccgcg ccccgtcctc cgccccgtcc tccgccccgt acggcgaccc
    17761 cgcccgggtg ctctccgccc gcctgtccgc gctgcacgag ccggtggcca cgctggtcga
    17821 gcagcgcgcc ggcacggacc ccacggccga cgacccgctg cgcggcctgt acctgtccga
    17881 cgaggcggtc cagcacctgc tggactcctg gccgtccgac gccgaagacg cggccccggg
    17941 acacgcgccc tccgggcccg tgcccgacgt cccgcaggcc gaccccgccg accggctggc
    18001 acggctggcc gcccggacga acctgaccga gctggacacc gccgtcctgc tgatcgccct
    18061 cgccccggac gtcgaccgca ccttcgaacc gctctacggc tacctcaaca acgacgtcag
    18121 ccgccggcgc gccagcgtga gcctcgccct cgaactgtgc ggtgtgcccg cgcacctggc
    18181 ggcggcccgc ggccggttcc acgcctcggc cccgctgctc tccctcggcc tgctggagct
    18241 ggaggacccc gagcggccct tcctcacccg tgcgctgcgg gtaccggacc ggctgatcgg
    18301 ccacctgctc ggcgacgaca caccggacgc ggcactcctc gggctgctgc gcccgatgcc
    18361 ggaagccctg cccgcgaccg gcaccgacga cttcgtacgg cagctggcgg cccggctgaa
    18421 ggaggggccg ctcaccgcct acctgcgcga accgcgcgag ggtgacggcc tggccgccct
    18481 ggcctccgtc ctggacgccg cgggcctcga cgcgctgcgc tgtgccgggg ccgaggacca
    18541 cgtgcccgag ctgctgcgcg aggcccgcct cagcggccgg gcggtcgtgg tgccgggcct
    18601 gcccgagaag ccggcggcgc tggtgcgcgc gctgaccgcg gcgacggacg tgaccgtgct
    18661 gttgaccgac ccccgcccgt acgacccgca ctgggccccc gacgatccgc tggtgctgga
    18721 cgcgccgggc cgccgggccg gtggcgccgc cgcctggcgg gccgcgctgg gcccggacgc
    18781 cgacgggttc gacctggcct cggccgtcgc gccgtaccgg ctcggcgggg accgcatcca
    18841 gcgggccgcg cacgccgccc tggccctcgc cgccttcgac ggcacaccgc tcagcgccga
    18901 gcacgtccgg ctggccgccc gccggcagtc ggcctccggc ctggagagcc acgcccggcg
    18961 gatccggcca gacgtggact ggcaggacct ggtgctgccc gacaagcccc tggtccagct
    19021 ccgcgagctg gccctgcggg cccgccaccg ggaccgggtc ctcggcgact ggcggctgag
    19081 cgcgggcggc gggcggggcc ggggcgtcct cggcctgttc gcgggcgagt ccggcaccgg
    19141 caagaccctg tcggcggagg tggtcgcggc cgacctcggc ctcgacctct acgtggtcca
    19201 gctgtcgtcg gtcgtcgaca agtacgtcgg cgagaccgag aagaacctcg aacggatctt
    19261 caccgaggcc gaccgcaccg acgccgtact cctcttcgac gaggccgacg ccgtcttcgg
    19321 caagcgctcc gaggtcaagg acgcgcacga caagtacgcc aacatggaga gcgcctacct
    19381 gctccagcgg ctggagtcct tcgacggcat cgccctgctc accaccaacc tgcgcgccaa
    19441 catcgacgag gcgttcaccc ggcgtctcga cctcgtggtc gacttcccgt tcccggaccc
    19501 cgaccagcgc ctggcgctgt ggcggcactg cctgtcccgg gtcccgtccg ccgaggacat
    19561 cgacccggag ccgctggccc ggaagttcga gctggccggc ggttcgatcc gcagtgcggt
    19621 ggtcaccgcc gcgtacctcg ccgccgggcg cgacgacacg gtgacggcgg acgacctcct
    19681 ggagggcgcc cgccgtgagt accgcaaggc cgggcggctg gtgcccggcg aaggcggctg
    19741 gtgagccggg acccccggcc gcctccgaga tcaaccccgc tccgggctca ttccttcttg
    19801 gggtggacga tccgccactc ctggtcgtcc aggttggtgc agtcggagat gttcagcttg
    19861 gcgtcgagtc cgccggtgcc gttgccctcg acgttcaggc acttgttgtt gctggcgtag
    19921 ttgcggatcc agtagtcgcc gctctcctgc ttgtcggccc accagagctg gttgtccgcc
    19981 ttggtcccgt cgcaggggta ctccgtgacg ggcgtcccca ccggcttcgc gccgtagtag
    20041 gggaggtcca tgcagagccg gtccttgacg ttgcggatct ggaagagggg gaggctgtcg
    20101 gggccgccgc ccttctcgta cttcacttcc agatcccaca tctggttgtc ctcgtcgccc
    20161 tcgatgcaca tggactgctg aacggggtcg tcgggcttgc ccttctcccg gccgacgagt
    20221 tcggcgcaca tcttggtggt ggtgttgtac agcatgacgt tctgggcggg caccacggac
    20281 ttcggcttgg gcttctcgga ctcaccaccg ccaccgccgc caccgccgtc tccggccccg
    20341 gcgtccttgt cgtcggtcgt ctcctcggtg gagggctgcg gcgccggttc ctcgaccgga
    20401 gcggactcgg ccgaactggg caacgtctca ggggcggcgc t
//
