LOCUS       NZ_CP036534            10399 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. VN1 chromosome, complete genome.
ACCESSION   NZ_CP036534
VERSION     NZ_CP036534.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. VN1
  ORGANISM  Streptomyces sp. VN1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8341703)
  AUTHORS   Nguyen,H.T., Pokhrel,A.R., Nguyen,C.T., Pham,V.T.T., Dhakal,D.,
            Lim,H.N., Jung,H.J., Kim,T.S., Yamaguchi,T. and Sohng,J.K.
  TITLE     Streptomyces sp. VN1, a producer of diverse metabolites including
            non-natural furan-type anticancer compound
  JOURNAL   Sci Rep 10 (1), 1756 (2020)
   PUBMED   32019976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8341703)
  AUTHORS   Pokhrel,A.R., Nguyen,H.T., Dhakal,D., Nguyen,C.T., Pham,V.T.T. and
            Sohng,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2019) Department of BT-Convergent Pharmaceutical
            Engineering, Institute of Biomolecule Reconstruction, Sunmoon-Ro221,
            Asan, Chungnam 333-708, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: HGAP3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011650445.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 03:53:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,284
            CDSs (total)                      :: 7,197
            Genes (coding)                    :: 7,083
            CDSs (with protein)               :: 7,083
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 44 of 114
            Pseudo Genes (incomplete)         :: 82 of 114
            Pseudo Genes (internal stop)      :: 3 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:32:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1684874
            Orig. end                         :: 1695273
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036534.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jae Kyung Sohng.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="9"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(231..1322)
                     /locus_tag="EZV63_RS07390"
                     /old_locus_tag="EZV63_07490"
     CDS             complement(231..1322)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989359.1"
                     /locus_tag="EZV63_RS07390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07490"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_037770523.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 3e-18, bitscore:
                     64.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRAVLHVKGRVLVGPEEVRDEVWVIDGRISYDRPAGAADVRTV
                     EGWALPGLVDAHCHVGLDRHGAVPADTAEKQALSDREAGTLLLRDAGSPSDTRWIDDRD
                     DLPKIIRAGRHIARTRRYIRNYAWEVEPDDLVAYVAQEARRGDGWVKLVGDWIDRDLGD
                     LSACWPRGAVEAAITEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTDDTIPLF
                     AERGVAIVPTLVNIATFPALADGGESRFPRWSAHMRRLHERRYDTVRNAYDAGIPVFVG
                     TDAGGALAHGLAGAEVAELVTAGIPPVEALSATTWAARRWLGRPGLEEGAPADLVVFDR
                     DPRADVRVLTDPRRVVLNGRVVG"
     gene            1527..2654
                     /locus_tag="EZV63_RS07395"
                     /old_locus_tag="EZV63_07495"
     CDS             1527..2654
                     /NRPS_PKS="Domain: Aminotran_5 (53-299). E-value: 4.1e-29.
                     Score: 93.6. Matches aSDomain:
                     nrpspksdomains_EZV63_RS07395_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976957.1"
                     /locus_tag="EZV63_RS07395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07495"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_037770520.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.9e-22, bitscore:
                     77.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLAPLGAGRFAAIEDRVARLLGTGQDVVVMQGEALLPLE
                     GAIRAAAGPGTVALNVVTGPYGQTFGDWLRDCGATVHDLAVPFHTAVSAGQVREALAAH
                     PETDFVSLVHAEAATGNTNPVGEIGEVVRAHGALFYLDAVASVGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWIDGGRKALLHAP
                     AQLEMLALEACVERIEAEGPETVMARHAAAAAATRAGALALGGLEPYVYEAKDAAPVAT
                     TLRTPSDVDASALVARALESDPALPLAAGGGALAGEMIRVNHYGRDATRGAVHGCLAAL
                     GAALAEKGLKADAEAARRAADRAWDGQGGTVLSGD"
     aSDomain        1686..2423
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS07395_Aminotran_5.1"
                     /evalue="4.10E-29"
                     /label="EZV63_RS07395_Aminotran_5.1"
                     /locus_tag="EZV63_RS07395"
                     /protein_end="299"
                     /protein_start="53"
                     /score="93.6"
                     /tool="antismash"
                     /translation="PGTVALNVVTGPYGQTFGDWLRDCGATVHDLAVPFHTAVSAGQVR
                     EALAAHPETDFVSLVHAEAATGNTNPVGEIGEVVRAHGALFYLDAVASVGAEPVLPDAW
                     GVDLCVIGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWIDGGRK
                     ALLHAPAQLEMLALEACVERIEAEGPETVMARHAAAAAATRAGALALGGLEPYVYEAKD
                     AAPVATTLRTPSDVDASALVARAL"
     misc_feature    complement(2685..2698)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.14"
                     /tool="antismash"
     misc_feature    complement(2728..2744)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.39"
                     /tool="antismash"
     misc_feature    2801..2818
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.57"
                     /tool="antismash"
     misc_feature    complement(2803..2818)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2813..2828
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2874..2890
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.66"
                     /tool="antismash"
     misc_feature    2947..2959
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            2984..3496
                     /gene="ectA"
                     /locus_tag="EZV63_RS07400"
                     /old_locus_tag="EZV63_07500"
     CDS             2984..3496
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448158.1"
                     /locus_tag="EZV63_RS07400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07500"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_031046591.1"
                     /transl_table=11
                     /translation="MTAAQADLQIDRPRVADGAALWRIARDSKVLDLNSSYSYLLWCRD
                     FAATSAVARDGHGVPVGFITGYVRPDRPDTLLVWQVAVDEAHRGRRLAASMLDGLAART
                     VTELGLTTLETTVSPDNTASQRLFASFAERHGARLEREVLFDTGLFPDGPHEPEVLHRI
                     GPLSAAG"
     gene            3628..4899
                     /gene="ectB"
                     /locus_tag="EZV63_RS07405"
                     /old_locus_tag="EZV63_07505"
     CDS             3628..4899
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (29-366). E-value: 6.1e-72.
                     Score: 234.4. Matches aSDomain:
                     nrpspksdomains_EZV63_RS07405_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="EZV63_RS07405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07505"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_031046586.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.3e-77, bitscore:
                     258.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRALGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNAVLKRALIDYLERDGVTHGLDMSTTAKRRFLETFQNIILRKRD
                     LPYKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVEDFMWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARV
                     EWLRALADLCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGMPMA
                     LTLFKPELDVWEPGEHNGTFRGNNPAFVTATATLETYWADGSAMEKQTRKRGEQVEQHM
                     IAITEENLADIKEYRGRGLVWGLEFHDKDRAGRVAKRAFELGLLIETSGPESEVVKLLP
                     ALTITPEELDEGMKTLARAVRETA"
     aSDomain        3715..4725
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS07405_Aminotran_3.1"
                     /evalue="6.10E-72"
                     /label="EZV63_RS07405_Aminotran_3.1"
                     /locus_tag="EZV63_RS07405"
                     /protein_end="366"
                     /protein_start="29"
                     /score="234.4"
                     /tool="antismash"
                     /translation="DRALGSRMYDEDGHEYLDFFAGAGSLNYGHNNAVLKRALIDYLER
                     DGVTHGLDMSTTAKRRFLETFQNIILRKRDLPYKVMFPGPTGTNAVEAALKLARKVKGR
                     ESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVEDFMWFERL
                     LEDQGSGLNKPAAVIVETVQGEGGINVARVEWLRALADLCERQDMLLIVDDIQMGCGRT
                     GAFFSFEEAGITPDIVTVSKSISGYGMPMALTLFKPELDVWEPGEHNGTFRGNNPAFVT
                     ATATLETYWADGSAMEKQTRKRGEQVEQHMIAITEENLADIKEYRGRGLVWGLEFH"
     gene            5001..5399
                     /locus_tag="EZV63_RS07410"
                     /old_locus_tag="EZV63_07510"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037840.1"
                     /locus_tag="EZV63_RS07410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07510"
                     /product="ectoine synthase"
                     /protein_id="WP_037770517.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.5e-52, bitscore:
                     174.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKELEGTDRHVKSASGTWETKRIVLAKEKVGFSLHETILY
                     AGMETEMWYANHIEAVVCTKGDAELTDRETGKKYHITPGTMYLLNGHERHTLKVNEEFH
                     CICVFNPPVTGREDHDENGVYPLLTEEV"
     gene            5406..6305
                     /gene="thpD"
                     /locus_tag="EZV63_RS07415"
                     /old_locus_tag="EZV63_07515"
     CDS             5406..6305
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976953.1"
                     /locus_tag="EZV63_RS07415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07515"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_037770513.1"
                     /sec_met_domain="PhyH (E-value: 1.7e-40, bitscore: 138.3,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTTNVTDLYPTRGATEVATPRQDPVVWGSPDTPGPVSQGDLQ
                     ALDRDGFLAIDQLIGPDEVEVYQRELERLTADPAIREDERSIVEPQSKEIRSVFEVHRI
                     SEVFAKLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLS
                     NMRTISVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGIPSDEA
                     LTKMASEYGVKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFS
                     APIRRPDFIGARDFTPVK"
     gene            complement(6385..7479)
                     /locus_tag="EZV63_RS07420"
                     /old_locus_tag="EZV63_07520"
     CDS             complement(6385..7479)
                     /NRPS_PKS="Domain: Aminotran_5 (28-358). E-value: 2.1e-24.
                     Score: 78.1. Matches aSDomain:
                     nrpspksdomains_EZV63_RS07420_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448151.1"
                     /locus_tag="EZV63_RS07420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07520"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_107405045.1"
                     /sec_met_domain="Aminotran_5 (E-value: 8.7e-18, bitscore:
                     63.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGEVPGPHSGAMESFENLVRAEFAPKTTYLNTASTGLLPARTLV
                     AMRDAAARAAEGQPLDMFADVEAARAAYARLMGVPATRVATGSSVATFSGLVAASLPEG
                     AEVLTAEADFASLVNPLYTRGGLKVRSVPLERLAESVGPDTALVAVSSVQSADGRLADL
                     PTLRDAARAHGARTLIDVSQSNGWLPTAADDFDYVAAVAYKWVLCPRGVAFLVVPEDLG
                     AAAGLRPLFAGWASGEHPWDSCYGPVEELAHSARRFDESPALFSYTGARQSLDLIGELG
                     VDAVHAHDTGLADRFRAGVRSLGHEPVPAPGSAIVSVPGLGHRQGGLSSAGVQVSDRAG
                     NLRAAFHVYNTAADVDRLLDVLAD"
     aSDomain        complement(6406..7395)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS07420_Aminotran_5.1"
                     /evalue="2.10E-24"
                     /label="EZV63_RS07420_Aminotran_5.1"
                     /locus_tag="EZV63_RS07420"
                     /protein_end="358"
                     /protein_start="28"
                     /score="78.1"
                     /tool="antismash"
                     /translation="TYLNTASTGLLPARTLVAMRDAAARAAEGQPLDMFADVEAARAAY
                     ARLMGVPATRVATGSSVATFSGLVAASLPEGAEVLTAEADFASLVNPLYTRGGLKVRSV
                     PLERLAESVGPDTALVAVSSVQSADGRLADLPTLRDAARAHGARTLIDVSQSNGWLPTA
                     ADDFDYVAAVAYKWVLCPRGVAFLVVPEDLGAAAGLRPLFAGWASGEHPWDSCYGPVEE
                     LAHSARRFDESPALFSYTGARQSLDLIGELGVDAVHAHDTGLADRFRAGVRSLGHEPVP
                     APGSAIVSVPGLGHRQGGLSSAGVQVSDRAGNLRAAFHVYNTAADVDRL"
     gene            complement(7551..8264)
                     /locus_tag="EZV63_RS07425"
                     /old_locus_tag="EZV63_07525"
     CDS             complement(7551..8264)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067467.1"
                     /locus_tag="EZV63_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07525"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_031046578.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHRDGVEVVHRSFELDP
                     GRAKDDVQPVLTMLTAKYGMSEAQAQAGEDNLGAQATAEGLDYRTRDRDHGSTFDMHRL
                     LHLAKERNLHAELLDAFYRGNFADERSVFNDDERLVELSVAAGLDADEVRAVLADPAAH
                     ADAVRADEREAAELGATGVPFFVLDRAYGVSGAQPAEVFTQALTQAWGERTPLKLIDDG
                     DAEACGPDGCAVPRS"
     gene            complement(8340..8843)
                     /locus_tag="EZV63_RS07430"
                     /old_locus_tag="EZV63_07530"
     CDS             complement(8340..8843)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329308.1"
                     /locus_tag="EZV63_RS07430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_07530"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_194962982.1"
                     /transl_table=11
                     /translation="MIDERATGRRVIRSVLPAEAGTLAALHHRARSTYYPDGLPEDGTD
                     WAAVWRTAVEHPDGHVLCAVEHGRIVALASFRVPEGGGRDTVKLFQFHVDPGHWRSGIG
                     TALHTACVEQWRADGHRDAVLDVHVDNERAQAFYARLGWLPDPHNPPAEGDHHLFLRYG
                     VPGE"
     misc_feature    complement(9346..9361)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(9550..9565)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.08"
                     /tool="antismash"
     misc_feature    complement(10263..10272)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 gtggcgaggc ggcgtgcggg catgcggaag gtgttgccgt tcaaggtggt gggaccccca
       61 gtgagacatg tgtgtgggac acacatgagc gacgtgcttg ggacccggaa agaatctccc
      121 cgcgtacgcc ccaccgtcag cgatccgagg tcacttcacc ccttcgtggg gttttggtgc
      181 atcctttcga atctcgcggc acgcgcgttc ccccaggtca ctcgcgtcgg ctaaccgacg
      241 acccgcccgt tgagcaccac ccggcgcgga tcggtgagca cgcgcacgtc ggcgcgcggg
      301 tcccggtcga acaccaccag gtccgccggc gcgccctcct ccaggccggg gcgcccgagc
      361 cagcgccggg cggcccaggt cgtggcggag agcgcctcga cgggcgggat gccggcggtg
      421 accagctccg cgacctccgc gcccgccaga ccgtgggcga gggcgcctcc ggcgtcggtg
      481 ccgacgaaga ccgggatccc ggcgtcgtag gcgttgcgga cggtgtcgta gcggcgctcg
      541 tgcagccggc gcatgtgggc cgaccagcgc gggaagcggg actcgccgcc gtcggccagc
      601 gcggggaagg tggcgatgtt gacgagggtc ggcacgatgg cgacgccgcg ctcggcgaag
      661 agcgggatgg tgtcgtcggt cagccccgtg gcgtgttcga cgcagtcgat cccggcctcg
      721 accaggtcgc gcagggagtc ctcggcgaag cagtgcgcgg tgacccgggc gcccaggcgg
      781 tgggcctcgg tgatggccgc ctccacggcg ccgcgcggcc agcacgcgga caggtcgccg
      841 aggtcgcggt cgatccagtc gccgaccagc ttcacccagc cgtcgccgcg ccgggcctcc
      901 tgggcgacgt acgcgacgag gtcgtcgggc tcgacctccc aggcgtagtt gcggatgtag
      961 cggcgggtgc gggcgatgtg ccggccggcc cggatgatct tcggcaggtc gtcgcggtcg
     1021 tcgatccagc gggtgtcgga gggcgagccc gcgtcgcgga ggagcagggt gcccgcctcg
     1081 cggtcggaca gggcctgctt ctcggcggtg tccgccggga ccgcgccgtg ccggtcgagg
     1141 ccgacgtggc agtgcgcgtc gaccaggccg ggcagcgccc acccctcgac ggtgcgcacg
     1201 tcggcggcgc cggcggggcg gtcgtaggag atccgcccgt cgatcaccca cacctcgtcc
     1261 cggacctcct cgggcccgac gagcacccgc cccttcacgt gcagcaccgc gcgatcagtc
     1321 atgcccgcac cctaacggtg cccgtacagg cgtccgggcg ggccgccggc cgtcggcccg
     1381 gggccgttcc ggccgtagcg gaagctacga ttccgggcgt gggggtgtcg caacggaagg
     1441 gctccggcgt gagtgccggc cggggccctg gttactctcg ttccactacg tgtcgtccac
     1501 ctgcccgtga gtgaagagag ccccgcatga cccacccgtt cctggacctc gctccgctgg
     1561 gcgccggccg tttcgccgcg atcgaggacc gggtcgcgcg gctgctcggc accgggcagg
     1621 acgtcgtggt catgcagggc gaggcgctgc tgccgctgga gggcgcgatc cgcgccgccg
     1681 ccggtccggg caccgtcgcg ctgaacgtcg tcaccgggcc ctacgggcag acgttcggcg
     1741 actggctgcg ggactgcggg gcgaccgtgc acgacctcgc cgtgccgttc cacacggccg
     1801 tgagcgccgg gcaggtgcgg gaggcgctcg ccgcacaccc ggagaccgac ttcgtgtccc
     1861 tggtgcacgc cgaggcggcg accgggaaca ccaacccggt cggggagatc ggcgaggtgg
     1921 tgcgggcgca cggcgcgctg ttctacctgg acgccgtggc ctccgtcggc gccgagccgg
     1981 tgctgccgga cgcgtggggc gtggacctgt gcgtcatcgg cgcgcagaag gcgatgggcg
     2041 gcccggccgg ggtgtcggcg gtgtcggtca gcgagcgggc gtgggcgcgg atggcggcga
     2101 acccgggcgc cccgcgccgg tcctacctct ccctcctcga ctggaaggag cgctggatcg
     2161 acggtggccg aaaagcgctg ctgcacgcgc cggcccagtt ggagatgctc gcgctggagg
     2221 cctgcgtgga gcgcatcgag gcggagggcc cggagacggt gatggcacgg cacgcggcgg
     2281 ccgcggcggc cacccgggcc ggcgcgctcg ccctgggcgg tctggagccg tacgtgtacg
     2341 aggcgaagga cgcggcgccg gtcgcgacga cgctgcggac cccctcggac gtcgacgcct
     2401 cggcactggt ggcccgggcc ctggagtcgg atccggcact gccgctggcc gccggcggag
     2461 gtgcgctggc cggggagatg atccgggtga accactacgg ccgggacgcc acgcgcgggg
     2521 cggtgcacgg ctgcctggcg gcactgggtg ccgcgctggc ggagaagggt ctcaaggccg
     2581 atgcggaggc cgcccggcgg gcggcggacc gggcatggga cggacagggc gggacggttc
     2641 tttcgggaga ctgaattccc ggggatttcc gaactacaca taaactgaat taaagaatat
     2701 ggatcagcac aggttcccat attcttctgc ccgctttctc ttgacctaaa cacaaagatt
     2761 ccgcggacct cgactctcgc atttcggaca cgtctcgcat cggttacgcg attgtgaccc
     2821 gatccacatg cggcccgctt cgcacctttt gaccggtaca aatcgccaca ttgcgcacac
     2881 tactcgcgcg gtggcacgcg cccgcgtgat aacacaggac gcctgcatcc gtaaccccgt
     2941 cccgcgatgc aatttcgaat ttccctgggt aaattcgatt tacatgactg ccgcgcaagc
     3001 agacctgcaa atcgatcgtc cgagagtggc cgacggcgcc gccctgtggc gcatagcgag
     3061 ggattccaag gtcctcgacc tgaactcgtc ctacagctat ctgctctggt gccgggactt
     3121 cgccgccacg tcggccgtcg cccgtgacgg gcacggcgtg ccggtcggct tcatcaccgg
     3181 ctacgtccgc ccggaccggc cggacaccct gctggtctgg caggtggcgg tggacgaggc
     3241 gcaccgcggg cgccggctcg ccgcctcgat gctcgacggg ctcgccgccc ggaccgtgac
     3301 ggagctcggg ctgaccaccc tcgagaccac cgtctccccc gacaacacgg cgtcccagcg
     3361 actgttcgcc tcgttcgccg agcggcacgg tgcccgactg gagcgcgagg tgctcttcga
     3421 caccggcctg ttcccggacg ggccgcacga accagaggtc ctccaccgca tcggccccct
     3481 gtccgcggcc ggctgacccg ccggccgccc ggacgccggg cacccccggc agtccggccc
     3541 ctgagacttc ccggccggga ccgcaccggt tccgccggac agtacgacct tcctctgaca
     3601 ccctcaccca acgaggagcg attcgtcgtg accatcaccc agcccgacct cagcgtcttc
     3661 gagaccgtcg agtccgaggt gcgcagctac tgccgcggct ggcccaccgt cttcgaccgt
     3721 gcgctcggca gccgcatgta cgacgaggac ggacacgagt acctcgactt cttcgccgga
     3781 gcgggttcgc tcaactacgg gcacaacaac gccgtcctga aacgcgcgct gatcgactac
     3841 ctggagcggg acggcgtcac gcacgggctc gacatgtcga ccaccgccaa gcgccgcttc
     3901 ctggagacgt tccagaacat catcctgcgc aagcgcgacc tgccgtacaa ggtcatgttc
     3961 ccgggcccga cgggcaccaa cgccgtcgag gccgcgctga agctggcgcg caaggtcaag
     4021 ggccgcgagt cgatcgtgtc cttcaccaac gccttccacg gcatgtcgct gggctcgctg
     4081 gccgtgaccg gcaacgcgtt caagcgggcc ggcgccggca tcccgctggt gcacggcacg
     4141 cccatgccgt tcgacaacta cttcgacggg accgtcgagg acttcatgtg gttcgagcgg
     4201 ctgctcgagg accagggctc cggtctcaac aagccggccg ccgtgatcgt ggagaccgtg
     4261 cagggcgagg gcggcatcaa cgtcgcccgc gtcgagtggc tgcgcgccct ggccgacctg
     4321 tgcgagcgcc aggacatgct gctcatcgtg gacgacatcc agatgggctg cggccgtacc
     4381 ggcgccttct tctccttcga ggaggcgggc atcacgccgg acatcgtcac cgtctccaag
     4441 tcgatcagcg gctacggcat gccgatggcg ctgaccctgt tcaagcccga gctggacgtc
     4501 tgggagccgg gtgagcacaa cggcaccttc cgcggcaaca acccggcctt cgtcacggcg
     4561 accgccacgc tggagacgta ctgggccgac ggctcggcga tggagaagca gacccgcaag
     4621 cgcggtgagc aggtcgagca gcacatgatc gccatcaccg aggagaacct cgcggacatc
     4681 aaggagtacc ggggccgcgg tctggtctgg ggcctggagt tccacgacaa ggaccgcgcg
     4741 ggccgggtcg ccaaacgcgc cttcgagctc gggctgctca tcgagacgtc cggccccgag
     4801 agcgaggtcg tcaaactcct gccggcgctc accatcacgc ccgaagagct ggacgagggc
     4861 atgaagaccc tcgcccgggc cgtgcgcgag acggcctgac cgctccggca ccgccccccc
     4921 tgcttccggc gcctcgggcc tcgcggcccg gggcgccggg gaccatggca cacccctcac
     4981 ctaggaggca tcgcaacacc gtgatcgtcc gttcgttcaa ggaactcgaa ggcaccgacc
     5041 gccacgtgaa gtcggcgtcg ggcacctggg agaccaagcg catcgtcctc gccaaggaga
     5101 aggtcggctt ctccctgcac gagacgatcc tgtacgcggg tatggagacc gagatgtggt
     5161 acgcgaacca catcgaggcc gtcgtctgca cgaagggcga cgcggaattg accgaccgcg
     5221 aaacggggaa gaagtaccac atcacgcccg gcaccatgta tctcctgaac ggccatgagc
     5281 ggcacacgct caaggtcaac gaggagttcc actgcatctg cgtcttcaat ccccccgtga
     5341 ccggacggga ggaccacgac gagaacggcg tctacccgct gctcaccgag gaggtgtgag
     5401 tcaccgtgac caccacgacc acgaacgtca ctgatctcta tcccacccgc ggcgccaccg
     5461 aggtggcaac cccccggcag gacccggtgg tctggggctc cccggacaca cccggtcccg
     5521 tctcccaggg cgacctccag gccctggacc gcgacggatt cctcgccatc gaccagctca
     5581 tcgggccgga cgaggtcgag gtctaccagc gggagctgga gcggctcacc gccgacccgg
     5641 ccatccgtga ggacgagcgc tcgatcgtcg agccgcagtc caaggagatc cggtcggtct
     5701 tcgaggtgca caggatcagc gaggtcttcg cgaaacttgt gcgcgacgag cgcgtggtcg
     5761 ggcgggcccg gcagatcctc ggctcggacg tctacgtcca ccagtcgcgg atcaacgtca
     5821 agccgggatt cggagccagc ggcttctact ggcactcgga cttcgagacc tggcacgccg
     5881 aggacggctt gtcgaacatg cgtacgatct cggtctcgat cgcactcacc gagaactacg
     5941 acaccaacgg tggtctcatg atcatgccgg ggtcgcacaa gacgttcctc gggtgcgcgg
     6001 gggccacgcc gaaggacaac tacaagaagt cgctgcagat gcaggacgcg gggatcccgt
     6061 ccgacgaggc gctgacgaag atggcgtcgg agtacggcgt caagctgttc accggcaagg
     6121 ccggctcggc gacctggttc gactgcaact gcatgcacgg ttcgggtgac aacatcacgc
     6181 cgttcccgcg cagcaacgtg ttcatcgtgt tcaacagcgt ggagaacacg gcggtcgagc
     6241 cgttctcggc accgatcagg cgaccggact ttattggggc gcgggacttc actccggtga
     6301 agtgagccgc atctgatctc gggcaggggc ctcttcgtgt gggacgggag gctcctgccc
     6361 gaagctgttc cgcgggctct tccctcagtc cgccagtacg tcgaggagac ggtccacgtc
     6421 ggccgcggtg ttgtacacgt ggaaggcggc ccgcaggttg cccgcccggt cggacacctg
     6481 gacgccggcg ctgctcagcc cgccctgccg gtggccgagc cccggcacgg acacgatcgc
     6541 ggaacccggc gcgggcaccg gttcgtggcc cagcgagcgc acccccgcgc ggaagcggtc
     6601 ggcgagaccg gtgtcgtggg cgtgcacggc gtcgacgccc agttccccga tcaggtccag
     6661 ggactgccgg gcgccggtgt acgagaacag ggcggggctc tcgtcgaagc gccgggcgga
     6721 gtgcgcgagt tcctcgacgg ggccgtagca gctgtcccag gggtgctcgc ccgacgccca
     6781 cccggcgaac agcggccgca gcccggccgc cgctcccaga tcctccggta cgacgaggaa
     6841 ggcgacgccg cgcgggcaga gcacccactt gtaggcgacg gcggcgacgt agtcgaagtc
     6901 gtccgcggcc gtcggcagcc agccgttcga ctgggacacg tcgatcaggg tccgcgcccc
     6961 gtgcgcgcgg gcggcgtccc gcagcgtggg caggtcggcg agccgcccgt cggccgactg
     7021 cacggagctg accgcgacga gcgcggtgtc cgggcccacc gactctgcga gccgctccag
     7081 cggcacactg cgcaccttca ggccgccgcg cgtgtacagg gggttcacca gcgaggcgaa
     7141 gtcggcctcg gcggtgagga cctcggcgcc ctcgggcagc gaggcggcga cgagcccgct
     7201 gaacgtggcg accgacgagc cggtcgcgac ccgggtggcg ggcaccccca tgaggcgggc
     7261 gtacgcggcc cgggccgcct cgacgtcggc gaacatgtcg agcggctgcc cctcggccgc
     7321 acgggccgcc gcgtcacgca tggcgacgag ggtccgggcg ggcagcaggc cggtactggc
     7381 ggtgttcagg tacgtggtct tcggggcgaa ctcggcgcgg acgaggttct cgaagctctc
     7441 catggcacca ctgtgcggtc ccgggacctc cccgtccatt gcgtatttct cagcggtttc
     7501 cccaagcaac gcttatgcat ggccgccgac ctgcggttct gacggggtcc tcagctccgg
     7561 ggcacggcac acccgtcggg gccgcacgcc tccgcgtccc cgtcgtcgat cagcttgagc
     7621 ggcgtccgct cgccccaggc ctgcgtcagc gcctgcgtga agacctcggc gggctgggcg
     7681 ccggagacgc cgtacgcccg gtcgagcacg aagaacggca cgccggtggc cccgagctcc
     7741 gcggcctcgc gctcgtcggc gcgcaccgcg tcggcgtggg cggcggggtc ggcgagcacc
     7801 gcgcggacct cgtccgcgtc gagcccggcg gcgacggaca gctcaacgag ccgctcgtcg
     7861 tcgttgaaca cggagcgctc gtcggcgaag ttgccccggt agaaggcgtc cagcagttcc
     7921 gcgtgcaggt tccgctcctt ggccaggtgc agcagccggt gcatgtcgaa ggtgctgccg
     7981 tggtcgcggt cccgggtgcg gtagtcgagg ccctcggcgg tggcctgcgc gccgaggttg
     8041 tcctcaccgg cctgcgcctg cgcctcgctc atgccgtact tggcggtgag catcgtcagt
     8101 accggctgca cgtcgtcctt ggcccggccg gggtccagct cgaaggaccg gtggaccacc
     8161 tcgacgccgt cccggtgcgg gaaggccgcg agcgccttct cgaagcgggc cttgcccacg
     8221 tagcaccacg ggcaggcgat gtcgctccag atctcgacgc gcatgtctcg gctcttctcc
     8281 aggtcgtacc gctgcggagg ccctccccgc ctcgtgcgtg aacgttcaag cagctggtct
     8341 cattccccgg gcacgccgta ccgcaggaag aggtggtggt cgccctccgc gggcgggttg
     8401 tgcgggtcgg gaagccagcc gaggcgggcg tagaaggcct gggcgcgctc gttgtccacg
     8461 tgcacgtcca ggaccgcgtc ccggtggccg tcggcccgcc actgctcgac gcaggccgtg
     8521 tgcagggcgg tgccgatgcc ggagcgccag tgaccggggt cgacgtggaa ctggaagagc
     8581 ttgacggtgt cgcgcccgcc tccctccggc acccggaagg aggcgagggc gacgatgcgc
     8641 ccgtgctcca cggcgcacag cacgtgtccg tcggggtgct ccacggcggt gcgccacacg
     8701 gccgcccagt cggtaccgtc ctcgggcagc ccgtccgggt agtacgtcga ccgcgcccgg
     8761 tggtgcagcg cggcgagggt cccggcctcg gcgggcagca cggaacggat cacccggcgc
     8821 ccggtcgcac gttcatcgat catgcacacc aggacgcgcg ggcccggcca cgcggttgcg
     8881 cgcagtcccg gtgagggagg tcgtccaggg gccgcgaacc gctaccgctc cagcaccccg
     8941 ttgaaccgcc gcggcagccc gagggggttc ccgtcccgca cctcgggcgg cagcagcgcc
     9001 tccggcaccc cctggtacgc caccggccgc agccaccgct cgatcgccgt gccgcccacc
     9061 gacgtggacg tcgacgtggt cgccgggtac ggccccccgt gatgctgggc cgccgccacg
     9121 gcgacccccg tcggccagcc gttcaccagc acccgcccgg ccagcggcgt cacctcggcg
     9181 aggacctcgg ccccgcgccc ctcccccgcc gcttccccgg cggagatctg cacggtcgcc
     9241 gtgaggttgc ccggcagccg ggagagcacg gcccgcacct cgtcggcgtc ctggtagcgg
     9301 accacgacgg tgaccggccc gaagcactcc tccaggagca ggtcgtgctc gccctcggcg
     9361 gccagccgcg cggccggcac ggtgaggaac ccggcggcga cggtgtgctc gccgcccgag
     9421 ccgggcgtca ccggcgagtc cacgtcgggc agcgccaccc gctcggcgac gccggccacg
     9481 aagttgtccc gcatgcggtg gtcgaggagg acaccggcgt cggtgtcgct gaccgcgtcc
     9541 gtgagggtct tgaccagccc gtcaccggcg gcgcccgccg gcacgaggac caggccgggc
     9601 ttgacgcaga actggccgac gcccagggtc atcgaaccgg ccagccccgc gccgatcgcg
     9661 tccgcccgct cggcggcggc ggcctcggtg acgacgaccg ggttcagcga gcccagctcg
     9721 ccgtggaagg ggatcggcac cggccgtgcc gccgccgcgt cgaagagcgc gcggcccccg
     9781 cgtacggacc cggtgaagcc ggccgccgcg accagcgggt gcttgaccag ctcgacgccc
     9841 gccccgaagc cgtggacgag gccgacgacg ccctcgggga tgccgtgccg ggcggcggcg
     9901 cggcgcagca ccttggcgac cagctcggac agggccgggt ggtcggggtg ggccttgacg
     9961 acgaccgggc agccggccgc gagggcgctc gcggtgtcgc cgccggggac cgagaaggcg
    10021 aaggggaagt tggacgccga gtagacggcg acgacgccga gcggcacctt gtagcggcgc
    10081 aggtccggga tgggcggagt ggcggtgtcg tcggggtggt tgacgaccac gccgaggaac
    10141 tcgccctcgt cgacgatgtc ggcgaaggcc cgcagttggt agctggtgcg ggcgagttcg
    10201 ccggtgaggc ggaccaggcc gagcgcggtc tccgcgtcgg cgacctcgac cagggtctcc
    10261 tcggccgcct tcaggtcgtc ggcggcgctg cgcaggaagg ccgcgcggac ggtccggtcg
    10321 gcgagcgcgc cccgggcggc gtgcgcggcg cggacggcgt cgtccacctc ctgggccgtg
    10381 gcttcgaccg cgacctgct
//
