LOCUS       NZ_CP036534            21128 bp    DNA     linear   CON 17-MAY-2024
DEFINITION  Streptomyces sp. VN1 chromosome, complete genome.
ACCESSION   NZ_CP036534
VERSION     NZ_CP036534.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. VN1
  ORGANISM  Streptomyces sp. VN1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8341703)
  AUTHORS   Nguyen,H.T., Pokhrel,A.R., Nguyen,C.T., Pham,V.T.T., Dhakal,D.,
            Lim,H.N., Jung,H.J., Kim,T.S., Yamaguchi,T. and Sohng,J.K.
  TITLE     Streptomyces sp. VN1, a producer of diverse metabolites including
            non-natural furan-type anticancer compound
  JOURNAL   Sci Rep 10 (1), 1756 (2020)
   PUBMED   32019976
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8341703)
  AUTHORS   Pokhrel,A.R., Nguyen,H.T., Dhakal,D., Nguyen,C.T., Pham,V.T.T. and
            Sohng,J.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2019) Department of BT-Convergent Pharmaceutical
            Engineering, Institute of Biomolecule Reconstruction, Sunmoon-Ro221,
            Asan, Chungnam 333-708, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: APR-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: HGAP3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_011650445.1-RS_2024_05_17
            Annotation Date                   :: 05/17/2024 03:53:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,284
            CDSs (total)                      :: 7,197
            Genes (coding)                    :: 7,083
            CDSs (with protein)               :: 7,083
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 44 of 114
            Pseudo Genes (incomplete)         :: 82 of 114
            Pseudo Genes (internal stop)      :: 3 of 114
            Pseudo Genes (multiple problems)  :: 15 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:32:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 467587
            Orig. end                         :: 488715
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036534.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jae Kyung Sohng.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="4"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11128](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11128)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    complement(157..177)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            324..887
                     /locus_tag="EZV63_RS01785"
                     /old_locus_tag="EZV63_01835"
     CDS             324..887
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031691.1"
                     /locus_tag="EZV63_RS01785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01835"
                     /product="TerB family tellurite resistance protein"
                     /protein_id="WP_031032661.1"
                     /transl_table=11
                     /translation="MAMWDKIKDQAKTFQQSQGTRGASGSGQGAQASGRPGSSGGSKTQ
                     LIGMFKSQLASVKTELKSGSYRDASMAMCALVAAADGHVEPAERTRVEELIVSNEVLQN
                     FPADQLRQRFNQHVDRLLANVEQGRSEALQVIAKASKKPEEARAVIQTGMVVAGADGVF
                     EPSEQQAIREACSALGISPAEFGV"
     gene            complement(940..2379)
                     /locus_tag="EZV63_RS01790"
                     /old_locus_tag="EZV63_01840"
     CDS             complement(940..2379)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128726.1"
                     /locus_tag="EZV63_RS01790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01840"
                     /product="hypothetical protein"
                     /protein_id="WP_194963108.1"
                     /transl_table=11
                     /translation="MHRRSRPAVVAAALAAVFLGTLGNVSAAPARAAVEPTAGQPVAAD
                     CPPAVAEKATCYTGQDENGAYYTMAVPHRWNGSLVVHAHGGPDLGDTSDPARSTEDLGR
                     WAVMVDEGYAWAGSSYRRGGYGARMAAADTENVRRLFTDRFGRPERTYLHGQSWGGNVA
                     AKVAETYGGRPGAYDGVLLTNGVLGGGSRGYDYRVDLRVVYQYYCHNHPRPTEPQYPLW
                     QGLRAGSTMTTAGLRARLQECTGYASDPADRTGPQQRNLDDILAVTGIPERTLESHLRF
                     ATFTFRDIVANRLDGRNPWSNRGVRYTGSHDDKALNAGVERFSADPTARRDLSYDSDLT
                     GKVSLPVLTMHAIDDPTAFVEHEAAYRATLRGAGRSGNLVQTFTKEHEHSSLSDSEYAN
                     SVAALDTWVSTGRRPSPRAIAASCAAFDATYGDGCFYDPGFRPAPHASRVLPRPGGLTW
                     PAMTAARERAWSRIQGVGIAP"
     gene            complement(2686..3792)
                     /gene="paaE"
                     /locus_tag="EZV63_RS01795"
                     /old_locus_tag="EZV63_01850"
     CDS             complement(2686..3792)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388024.1"
                     /locus_tag="EZV63_RS01795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01850"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_166623492.1"
                     /transl_table=11
                     /translation="MAPTAPVPAAPVRARRRPAFHRLRVAAVERLCADAVAVRFEVPDE
                     LAGAYAFAPGQSLTLRREVDGRDERRSYSICAAAGSAPRIGVRVVPGGLFSAWLVDEVR
                     PGDTVEVMTPTGLFTPDLTVPGHHVLIAAGSGITPMVSIAESVLAADDRSTVTLFYGNR
                     RTGTVMFADELADLKDLHPARFQLAHVLSREPREAELLSGRLDAERLTALVGSLVDVEA
                     AGHWWLCGPQGMVADAQQVLAGLGVPADRVHRELFFADDEPVREVHHEEGGPRGPVSEV
                     TVTLDGRSTTASLSRERSILDGAQQTRPDLPFACKGGVCGTCRALVTDGKADMRRNYAL
                     EAAEVDAGYVLTCQSYPVSEQLTVDYDS"
     gene            complement(3792..4306)
                     /gene="paaD"
                     /locus_tag="EZV63_RS01800"
                     /old_locus_tag="EZV63_01855"
                     /pseudo=""
     CDS             complement(3792..4306)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388025.1"
                     /locus_tag="EZV63_RS01800"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01855"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVTAGPALPDAHRARRVAERVPDPELPMLTLADLGVLRDVETRAD
                     GTVVASLTPTYSGCPAMAEMRADVAARLRAAGYARVEIRTVLDPPWTSDWITESGRRKL
                     AEHGIAPPGRAPAARSRCCCRPPGPRCPAPAAGRGRPRRPRASPPPPARPCGAAGPAAS
                     RSST"
     gene            complement(4300..5127)
                     /gene="paaC"
                     /locus_tag="EZV63_RS01805"
                     /old_locus_tag="EZV63_01860"
     CDS             complement(4300..5127)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326306.1"
                     /locus_tag="EZV63_RS01805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01860"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_166623493.1"
                     /transl_table=11
                     /translation="MSDDHVYLTLAEGHEDDTRWAYGTGFEDPLHGVDTTVPEGVDAAG
                     LAAECVALADDALVGAQRLAEWITRAPELEEEVALANIGLDLLGQARLLYTRAGQADGT
                     GRDEDAYAYFRDPADFRNVTLAELPGGDFAFTVVRLLVLSSWRLAHFRGLVDHPDPVLA
                     AVAAKGAKELTYHRQYAAQWCVRLGDGTDESHRRMRAALEQVAPYLGELHTAHDVRDEV
                     AADLRQVTDAAGLLLPVYRPRPGSGRAGEHTEHLAPLLTELQGIARAHPEATW"
     misc_feature    5134..5148
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            complement(5137..5439)
                     /gene="paaB"
                     /locus_tag="EZV63_RS01810"
                     /old_locus_tag="EZV63_01865"
     CDS             complement(5137..5439)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971670.1"
                     /locus_tag="EZV63_RS01810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01865"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_031032668.1"
                     /transl_table=11
                     /translation="MSDDRPERQGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALTHAR
                     DLYTRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPDDVPHI"
     gene            complement(5436..6422)
                     /gene="paaA"
                     /locus_tag="EZV63_RS01815"
                     /old_locus_tag="EZV63_01870"
     CDS             complement(5436..6422)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003132.1"
                     /locus_tag="EZV63_RS01815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01870"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_031032670.1"
                     /transl_table=11
                     /translation="MTTTHAAEAPPPQGPDGLQEHFDATVARDQRVEPRDWMPDGYRKT
                     LIRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RDDLTERLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTPAQREMVQDAVDRWWWPSLMMFGPPDDASPNSAR
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEEAGHHDFGTPDWDELTR
                     VIKGDGPCNAQRTERRRTAHEEGAWVREAATAHAAKQAARTQKGAAV"
     misc_feature    6441..6454
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     misc_feature    6561..6576
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.17"
                     /tool="antismash"
     gene            6649..>7005
                     /gene="paaI"
                     /locus_tag="EZV63_RS37520"
                     /pseudo=""
     CDS             6649..>7005
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662295.1"
                     /locus_tag="EZV63_RS37520"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hydroxyphenylacetyl-CoA thioesterase PaaI"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFAADQASRGLGIELVEQGAGSAVVRMTVTPAMVNGHRIAHGGFL
                     FLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVARAEERARYGRSGIYDVSVR
                     RGDEVIAEFRGRSRS"
     gene            7167..8513
                     /gene="paaK"
                     /locus_tag="EZV63_RS01825"
                     /old_locus_tag="EZV63_01880"
     CDS             7167..8513
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (101-352). E-value: 6e-20.
                     Score: 63.1. Matches aSDomain:
                     nrpspksdomains_EZV63_RS01825_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971673.1"
                     /locus_tag="EZV63_RS01825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01880"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_166623495.1"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-25, bitscore:
                     86.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPTTEAAPTSRRGEPLPHDLLDDAERLSCEQLRELQLDRLRA
                     TLRHAYDNVELYRKKFDAAGVVPDDCRSLADLSRFPFTTKADLRETYPFGMFAVPMADV
                     RRVHASSGTTGRATVVGYTDNDLSAWADVVARSIRAAGGRPGHKVHVSYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLDEFERQGVDPRTT
                     SLQVGIFGAEPWTEEMRREIEERAGIHAVDIYGLSEVMGPGVAQECVETKDGLHVWEDH
                     FYPEVVDPLTDAVLPGGEEGELVFTSLTKEALPVVRYRTRDLSRLLPGTARPAFRRMSK
                     VTGRCDDMIILRGVNVFPTQIEEIVLRTPGVAPHFQIRLTARGRMDHLTVRVEARPDAG
                     PEQREAAARAIGQSVKDGVGVSVEVEIVDPETLERSLGKLHRVKDLRTA"
     aSDomain        7470..8222
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EZV63_RS01825_AMP-binding.1"
                     /evalue="6.00E-20"
                     /label="EZV63_RS01825_AMP-binding.1"
                     /locus_tag="EZV63_RS01825"
                     /protein_end="352"
                     /protein_start="101"
                     /score="63.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ADVRRVHASSGTTGRATVVGYTDNDLSAWADVVARSIRAAGGRPG
                     HKVHVSYGYGLFTGGLGAHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYM
                     LTLLDEFERQGVDPRTTSLQVGIFGAEPWTEEMRREIEERAGIHAVDIYGLSEVMGPGV
                     AQECVETKDGLHVWEDHFYPEVVDPLTDAVLPGGEEGELVFTSLTKEALPVVRYRTRDL
                     SRLLPGTARPAFRRMSKVTGRCDDMIILR"
     CDS_motif       8190..8252
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EZV63_RS01825_0001"
                     /evalue="2.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="EZV63_RS01825"
                     /protein_end="362"
                     /protein_start="341"
                     /score="13.8"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQIE"
     gene            8623..9921
                     /locus_tag="EZV63_RS01830"
                     /old_locus_tag="EZV63_01885"
     CDS             8623..9921
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971674.1"
                     /locus_tag="EZV63_RS01830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01885"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_166623496.1"
                     /sec_met_domain="FMO-like (E-value: 3.6e-79, bitscore:
                     265.3, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.2e-10, bitscore:
                     38.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLAVAHALKERGISFVCLEKAPDVGGIWRQPGAG
                     ERGPGYLSLHLNTAKQLTGYADFPMPSSYPLYPRHSQFAAYLRSFAEWAGLLGHVELRT
                     EAVSVRQDADGGWTVVSRDADGAETSRRFEQVVVASGHHTDPALPDPLPAGADSFTGTI
                     LHSLDYRDGGDFDGRRVVVVGLGASAVDIAADLSRHAEQTLLSVRRGLHIVPKQLFGMS
                     VDEIAEAPWWTEMSFAEQRRWVEQALLVARGRLGDYGLPEPDHPVFSSATTLSDEILSR
                     IRHGAVTPKPAIGSFDGDRVVFTDGTSVTADAVVYCTGFRMTFPFLPAGCPVAADGSVA
                     LYRRVVPADRPGLYFVGLVRPVGSITRLVEAQAQWVARLVDGEAELPAAGEMREEIATY
                     LTGIVQRYGRAPGASVQVDVGPYLAEFRESLPV"
     gene            complement(10001..11128)
                     /locus_tag="EZV63_RS01835"
                     /old_locus_tag="EZV63_01890"
     CDS             complement(10001..11128)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388029.1"
                     /locus_tag="EZV63_RS01835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01890"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_037770305.1"
                     /sec_met_domain="indole_PTase (E-value: 4.5e-143, bitscore:
                     475.2, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPTGADPRDTPTLGALTGGQLRRLAAVAGLSATDTAAYVRVL
                     TDSLGPVAARPLSLPPPTRTFLSDDHTPVEYSLSFRPDAAPALRVLLEPGCGADSLARN
                     GRVGLEAVRRMARRWHFTTDALDEIEELFLPSGPRGPLALWCALELRPGGVPGVKVYLN
                     PAANGAERSAATVREALHRLGHRRAFAALPQGAGYPFLALDLGEWAQPRVKVYVRHDNL
                     TAGRAGRLSRTDRGPGPAAIEGFFRAAAALGPDVAGLGRRPALSCHSFTDTADVRPSGF
                     TLHIPVRDYVRHDGEALARAARVLRHHGMDPSVLVRALAAVTGRRLEDGAGLVAYLALA
                     HQQGHPPRVTAYLSAEAYAVRPAVGGSAPTAMPVG"
     misc_feature    11124..11139
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(11254..11267)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            complement(11336..12682)
                     /locus_tag="EZV63_RS01840"
                     /old_locus_tag="EZV63_01895"
     CDS             complement(11336..12682)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972616.1"
                     /locus_tag="EZV63_RS01840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01895"
                     /product="cytochrome P450"
                     /protein_id="WP_166623497.1"
                     /transl_table=11
                     /translation="MNAHDPAPVPPPGCPAHGSGARVPLHGPEFAADPQAYYEYLRHYG
                     AAAPVELAPGVEATLVTDYTAALQLLQDSGSFRKDARRWRAFNEGKVGPDSPVAPLLAY
                     RPNCMFADGADHLRLRQAVTDSMARVDTRRLSRSTEQISRYLISQFAARGSADLLGDYA
                     KQLPLFVFNELFGCPADIGDRVLFGISGMFDGVNAEKATEVLFQAVGELVALKREKPGD
                     DVTSWLMRHEAGLDDEEMVHQLALLLGAGAEPLRNLVGNTLHRLLTHERYAREGGLIDE
                     ALDDTLWENPPMSNYAPHYPAADTEFAGQQLQAGDLVLVSFAAANTGPALRASRQAGSN
                     RAHLAWSAGPHACPSKEPARHITVTAIEHLLNELPDVALAVPEDSLAWRPGPFNRALAT
                     LPARFTPVRSVRRTEPRPAPAAEQEKAAAPARPAERAGMWSQFLNWLTR"
     misc_feature    complement(12675..12686)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            complement(12698..13288)
                     /locus_tag="EZV63_RS01845"
                     /old_locus_tag="EZV63_01900"
     CDS             complement(12698..13288)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005331.1"
                     /locus_tag="EZV63_RS01845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01900"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_037770300.1"
                     /transl_table=11
                     /translation="MGSAPSLDERDYVREGATQTAVKILVVGHFAVGKTTLIGSISEIE
                     PLSTEETMTQAAEPVDDLKGVKGKTTTTVAMDFGRLTISDRIVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFPVIDLIEHYGLDYAIAVNHFDGAPARDERALREALD
                     LLDDTPVVTCDARDEKSSAAALTTLVRHLLDRA"
     gene            complement(13263..13640)
                     /locus_tag="EZV63_RS01850"
                     /old_locus_tag="EZV63_01905"
     CDS             complement(13263..13640)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="EZV63_RS01850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01905"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_037770296.1"
                     /transl_table=11
                     /translation="MTGRDGWTPESAALVRPYVITKGRNLPDEEALSLLTLVTASAEDT
                     RRPARLSPEEQSLLDLCSAGYLSVAEIAGHTHFPLGVVRILLASLMEGGHLLTRPPVAR
                     ARLADREILEEVLNGLRAKFG"
     misc_feature    complement(13599..13601)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13637..14038)
                     /locus_tag="EZV63_RS01855"
                     /old_locus_tag="EZV63_01910"
     CDS             complement(13637..14038)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="EZV63_RS01855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01910"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_031032694.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDFDKDDADRV
                     AAAMSGVQSLSRTLSFFCEDPGQNWRQTLVEFDGGWVFLISAGEGAYLGVSASPEVDMA
                     DITFRMQQLVAQLGKRLTTPPRENLGARS"
     gene            complement(14035..15216)
                     /locus_tag="EZV63_RS01860"
                     /old_locus_tag="EZV63_01915"
     CDS             complement(14035..15216)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="EZV63_RS01860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01915"
                     /product="ATP-binding protein"
                     /protein_id="WP_166623498.1"
                     /transl_table=11
                     /translation="MTEYTANPLLWVLLVALVAAAVLVSRQRRAARALRQQVQGLRDRY
                     TQLENNYGKSVQAAQERAEDETKTVLKSAMRTLQGLAAEQQLVLSRLQSKYGESALLED
                     LLEIDHTNSQFGRRAQSVAVLCDGWLGGRRDTASVYDVVRSAQGRIRHFRRVDILSRVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINIRTVPKGICVVVDDAGVGMSDEER
                     ARADKLLATERASGVAALGNPPQFGFAVIGLLCERFGFEVSVDSSSPYGGVRAVVLLPH
                     DMLTAMPEKRAPAPADRPTARPVPDGGPEAAPAASRTDDGLPRRRRKRPMAIVPGSASA
                     PRPAGRSDSEQARVMGAFQRGTRSGRGTEPENAENADRTSSTPGASSEGHEVS"
     misc_feature    complement(15402..15411)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.82"
                     /tool="antismash"
     gene            15549..16301
                     /locus_tag="EZV63_RS01865"
                     /old_locus_tag="EZV63_01920"
     CDS             15549..16301
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324211.1"
                     /locus_tag="EZV63_RS01865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01920"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_194962956.1"
                     /transl_table=11
                     /translation="MAAVFAAGVGAGAINSVVGSGTLITFPVLLATGLSPVTATVSNAL
                     GLIPGSISGAIGYRKELTGQRRRVLKLGAGALLGGLAGATLLLSLPPDAFETIVPVLVG
                     LALVLVAFQPQIGRLVQRRRERTGASPRRDGGPLLLVGLTLASVYGGYFTAAQGIIYLS
                     LMGMLLDEPMQRLNGVKNVLSAVVNTVAALFFLFAADFDWTAVGLLAVGSALGGWFGAK
                     VGRRFSPLVLRILVVTVGTVALAQLLLR"
     misc_feature    16418..16433
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.79"
                     /tool="antismash"
     gene            16482..17840
                     /locus_tag="EZV63_RS01870"
                     /old_locus_tag="EZV63_01925"
     CDS             16482..17840
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639923.1"
                     /locus_tag="EZV63_RS01870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01925"
                     /product="cytochrome P450"
                     /protein_id="WP_031032700.1"
                     /sec_met_domain="p450 (E-value: 1.5e-78, bitscore: 263.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVAPPPIPRAAGSLPFLGHAVQLMRDNLGFVAALRTTYGPLVE
                     ITLQPGTRTLVVQDPGLIRTMLTDLGPSLDKGRFFEKMGQLLGDSVVTAAGQVHVRKRR
                     QLQPAFAREQIARYVDTMRAETDAAVDEWVPGRPLDVREAMVGLSLNMLAKTIFSGSLD
                     DATFRRLRADLSVVMNGVGARVMLPDWVERLPLPANRRFNAARDGVRATIERAVSDLQD
                     SGHDTGDMLSLLLRTTDEETGEPLTGHQISSEILTLAVAGTETTASVLSWMLYELARNP
                     EVEARVLEELDEVLGDRPVAFDDLGRLPYLGRVVEETLRMHHTGWLVTRRTVTETRLGP
                     WTVPPGTELAYCQHALHRDPLLFRDPLEFDPDRWLDDPGPRPTQGFLPFGAGKHKCIGD
                     RFAFTELVTAVATIVRRVRLELAPGQTVRPVAAATVRPRTLLMTVREKEGQEA"
     misc_feature    17917..17935
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.64"
                     /tool="antismash"
     gene            17976..18812
                     /locus_tag="EZV63_RS01875"
                     /old_locus_tag="EZV63_01930"
     CDS             17976..18812
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324209.1"
                     /locus_tag="EZV63_RS01875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01930"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_031032702.1"
                     /transl_table=11
                     /translation="MTGRTASSPTPDHDDDVLRLQDVSVRRLTTDQLILDGVDWSVRPG
                     EHWALLGANGAGKTTLLRLLGALMHPTTGTVEVLGSRLGRVDVRELRARIGHVNSAQRV
                     PQDLTAHAVVLTGHSGTVQPLWRTYDDEVRERARDLLTELGVKELADRPYGVCSGGQRA
                     RILIARALMADPALLLLDEPFNALDLPSREDLVEAMHQLTEGRPRLATVTVTHHLEELF
                     PAVSHTLLLREGRILSRGPVDDVLTDDLLTACFGREITVARRDGRWSAFSGRRTRG"
     gene            complement(19052..19417)
                     /locus_tag="EZV63_RS01880"
                     /old_locus_tag="EZV63_01935"
     CDS             complement(19052..19417)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992805.1"
                     /locus_tag="EZV63_RS01880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01935"
                     /product="transglycosylase family protein"
                     /protein_id="WP_037770279.1"
                     /transl_table=11
                     /translation="MICRRNALQGNVRRSHGRTIRTAAAALLAAAALAATTGAAASASV
                     PLRTDWDSIAACESGGDWQANTGNGYYGGLQFAPSSWAAAGGLKYAPRADLATRAEQIA
                     VAKRLAGLQGMSAWGCA"
     gene            complement(19520..20989)
                     /locus_tag="EZV63_RS01885"
                     /old_locus_tag="EZV63_01940"
     CDS             complement(19520..20989)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324207.1"
                     /locus_tag="EZV63_RS01885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EZV63_01940"
                     /product="sialate:H+ symport family MFS transporter"
                     /protein_id="WP_070387330.1"
                     /transl_table=11
                     /translation="MSSARTTAKPRPWYREITRQKWKSFFAAWIGYLLDGFDFVLITLV
                     LTEIADDFGLSTVESASLVSGAFITRWLGGAVLGALGDRFGRRSAMVASILLYSVGTFA
                     CGFAWDYTSLFTARLLIGMGMAGEYSASATYVLESWPARLRNRASGFLISGFSLGGVLA
                     AEVYEHVVPGHGWRWLFYIGLFPVVVALWVRRSLPEADDWEARVGATGERPNPFRPLFA
                     GRRRASVNTVLAVVATGSLFAVFTPLGAGAVPVLSVVATACLVAFAVQLGGRKRWLLFV
                     ALCATVFCAFLYSWPVQALLPTYLKTELGFTPAQVSDALYYAGFGTMAGCIVTGFVGDR
                     FGTRRAYACTLAVGIAFVFPVFAIRDSQLQLGILLFLMLACMQGISGLLPKYIAGHFPT
                     ETRAASLGFTYNVGALGGAVAPVLGARLASSMSLGQSLAVLTFSLTLVVILLIGFDVPS
                     RLNRLVDPEAVPDYLATEAAADGAPSAPSAK"
ORIGIN
        1 cacaggcgca gcgcccagta cagcaacgcc tgccccgccg tcgacacgac gccgatcgcg
       61 acgaaccagc cgacctgccg cgaccacacc gtacgctccc gcccggccgc cggttcggcg
      121 acgtctgtcg gcgcagccta ctacgccccc atcagcccct ttgccttttc tttgccttta
      181 gggaaccctg tggtgccacg gcccgttcat cctggtggct gcggaaaccc cgcgggagac
      241 cgcgggttgg gaccgggccg gaacgcacga cggccggacg cacaacagcc agacgcacaa
      301 caacagaagc cgaggtggca cgagtggcga tgtgggacaa gatcaaggac caggccaaga
      361 ccttccagca gtcccagggc actcggggag cgagcggatc cggccagggc gcgcaggcga
      421 gcggccggcc gggttcgtcc ggaggctcca agacgcagct gatcgggatg ttcaagtccc
      481 agctcgcgtc ggtcaagacc gagttgaaga gcggctccta ccgggacgcc agcatggcca
      541 tgtgcgcgct ggtcgccgcg gccgacgggc acgtggaacc ggctgagcgc acgcgcgtgg
      601 aggagctgat cgtctccaac gaggtgctgc agaacttccc cgcggaccag ctccgtcagc
      661 ggttcaacca gcacgtggac cggctcctcg ccaacgtcga gcagggcagg agcgaggccc
      721 tgcaggtgat cgccaaggcg tcgaagaagc ccgaggaggc tcgtgccgtc atccagaccg
      781 gcatggtcgt cgccggggcc gacggggtct tcgagccctc cgagcagcag gcgatccgcg
      841 aggcctgctc cgccctgggc atctcgcccg cggagttcgg cgtctgacac accacgaggt
      901 ccgcccggcg cgctcgacgt gccgggcgga ccgggccggc tagggcgcga tccccacgcc
      961 ctggatcctg ctccacgccc gctcccgcgc ggcggtcatg gcgggccagg tgaggccgcc
     1021 cggccggggc agcacccgcg aggcgtgcgg cgcggggcgg aaaccggggt cgtagaagca
     1081 gccgtcgccg tacgtcgcgt cgaaggcggc gcaggaggcc gcgatcgccc gcgggctcgg
     1141 ccgccggccg gtgctgaccc aggtgtccag cgcggccacg gagttggcgt actcggagtc
     1201 gctcagcgaa ctgtgctcgt gctccttcgt gaacgtctgg acgaggttcc cgctccgtcc
     1261 cgcgccccgg agggtggcac ggtaggccgc ctcgtgctcc acgaaggccg tcgggtcgtc
     1321 gatggcgtgc atcgtgagga cggggaggga caccttgccg gtgaggtcgc tgtcgtagga
     1381 caggtcacgg cgcgcggtgg ggtcggccga gaagcgttcg acgcccgcgt tgagcgcctt
     1441 gtcgtcgtgc gagccggtgt agcgcactcc ccggttgctc cacgggttcc gcccgtcgag
     1501 ccggttggcc acgatgtccc ggaacgtgaa ggtggcgaac cgcagatgcg actccagggt
     1561 gcgctcggga atgcccgtga cggcgaggat gtcgtcgagg ttgcgctgct gcggcccggt
     1621 ccggtcggcc gggtccgagg cgtagcccgt gcactcctgg aggcgggcgc gcagcccggc
     1681 ggtcgtcatc gtggagccgg cccgcagccc ctgccacagg gggtactgcg gctcggtcgg
     1741 gcgcgggtgg ttgtggcagt agtactggta gaccacccgc aggtccacgc ggtagtcgta
     1801 gccgcgcgaa ccgccgccga gtacgccgtt ggtcagcagc accccgtcgt aggcgccggg
     1861 gcgtccgccg tacgtctcgg cgaccttggc cgcgacgttg ccgccccagg actggccgtg
     1921 caagtaggtg cgctccgggc ggccgaaccg gtcggtgaac aggcgccgca cgttctcggt
     1981 gtcggcggcc gccatgcggg ccccgtaacc gccgcgccgg taggaggaac ccgcccaggc
     2041 gtacccctcg tcgaccatca ccgcccagcg tcccaggtcc tcggtgctgc gggcggggtc
     2101 ggaggtgtcg ccgaggtcgg gacccccgtg ggcgtgcacg acgagggaac cgttccagcg
     2161 gtggggcacg gccatcgtgt agtaggcccc gttctcgtcc tgcccggtgt agcaggtggc
     2221 cttctcggcg acggcgggcg ggcagtcggc ggccaccggc tgcccggccg tcggctccac
     2281 ggccgcccgg gccggggcgg cggagacgtt gccgagggtg ccgaggaaca cggccgccag
     2341 cgcggcggcc accaccgcgg ggcggcttct gcggtgcatg gccccggtgg catgcgtggg
     2401 agcgtcgggt gtggtcaagg tgcggctcct gtacgtgctg cgtgcgggcg cgatattgcg
     2461 ctgcgagccg ggatgttagg aaccgtccgg agccggggcc agcctttgga tcattgcgtt
     2521 catagtgttc gcccgtcccg gcggcggccg gccgggacgg gcgtgcgctc ggcagccgtg
     2581 ccactgggcg gtcgtcgtct ccgctgatcg tcgtctccgc ggtcgtcgtc tccgcggtcg
     2641 tgcgctcagc agccgtgcgc gctgccgtgg gccggtcgcg cggcctcagc tgtcgtagtc
     2701 cacggtcagc tgctcggaga ccgggtagga ctggcaggtc agcacgtaac cggcgtcgac
     2761 ctcggccgcc tccagggcgt agttgcgacg catgtcggcc ttgccgtcgg tgaccagggc
     2821 gcggcaggtg ccgcacacgc cgcccttgca ggcgaacggg aggtcgggcc gggtctgctg
     2881 ggcaccgtcg aggatgctcc gctcccggga gagggaggcg gtggtggagc ggccgtccag
     2941 ggtgacggtg acctcgctga ccggcccccg ggggccgccc tcctcgtggt ggacctcgcg
     3001 cacgggctcg tcgtcggcga agaacagctc ccggtggaca cggtccgcgg gcacgccgag
     3061 gccggccagg acctgctggg cgtcggcgac catgccctgc ggcccgcaca gccaccagtg
     3121 gccggcggcc tccacgtcca ccagggagcc gaccagcgcg gtgagccgct cggcgtccag
     3181 gcggccggag agcagctcgg cctcgcgcgg ttcgcgggag aggacgtggg cgagctggaa
     3241 gcgggccggg tggaggtcct tcaggtcggc cagttcgtcg gcgaacatca ccgtgccggt
     3301 gcggcggttg ccgtagaaga gggtgacggt ggagcggtcg tcggcggcga gcaccgactc
     3361 ggcgatggac accatcggcg tgatgcccga accggccgcg atcagcacgt ggtggcccgg
     3421 gacggtcagg tcgggcgtga agaggccggt gggcgtcatc acctcgacgg tgtcgcccgg
     3481 gcgcacctcg tccaccagcc aggcggagaa caggccgccc ggcaccaccc gcaccccgat
     3541 gcggggagcc gaaccggccg ccgcgcagat cgagtaggaa cggcgctcgt cccggccgtc
     3601 gacctcgcgc cgcagggtga gcgactgtcc gggcgcgaag gcatacgccc cggccagctc
     3661 gtccgggacc tcgaagcgca cggcgaccgc gtccgcgcac agccgctcca cggccgcgac
     3721 gcgcaggcgg tggaaggcgg ggcggcggcg ggcgcgcacg ggggccgccg gtacgggggc
     3781 ggtcggggcc atcagatctc cttcacgtac tcgaacggct cgcggcaggt ccggcagcgc
     3841 cacagggcct tgcaggaggt ggcggcgaag cgcgaggtct cctcggtctc ccgcgacccg
     3901 cagcgggggc agggcaccgc gggccgggtg ggcgacagca gcagcgggac cgggccgcgg
     3961 gggcgcggcc gggcggggcg atgccgtgct cggcgagctt gcggcggccg gactccgtga
     4021 tccagtcgct ggtccagggc gggtccagga cggtgcggat ctccacgcgc gcgtaccccg
     4081 ccgcacgcag ccgtgcggcg acgtccgcgc gcatctccgc catggccggg caccccgagt
     4141 aggtgggggt caggctcgcg accacggtgc cgtccgcccg cgtctcgacg tcgcgcagga
     4201 cgcccaggtc ggcgagggtc agcatgggca gctcggggtc cggcacgcgc tcggcgacgc
     4261 gccgggcgcg gtgggcgtcc gggagggcgg ggccggcggt caccatgtcg cctccgggtg
     4321 ggcgcgggcg atgccctgca actcggtgag cagcggcgcc agatgctcgg tgtgctcgcc
     4381 cgcgcggccg gagccgggcc gcgggcggta gaccggcagg agcagtccgg cggcgtcggt
     4441 gacctggcgc aggtcggcgg caacctcgtc ccgcacgtcg tgggccgtgt gcagttcgcc
     4501 gaggtagggg gcgacctgct ccagcgccgc ccgcatccgg cggtgcgact cgtccgtgcc
     4561 gtcgcccagg cgtacgcacc actgggcggc gtactgccgg tggtaggtca gctccttggc
     4621 gcccttggcg gcgaccgccg cgaggaccgg gtccgggtgg tccaccagcc cccggaagtg
     4681 cgccaggcgc cagctggaga gcaccagcag ccgtacgacg gtgaacgcga agtcgccgcc
     4741 gggcagttcc gccagcgtca cgttgcggaa gtcggcgggg tcgcggaagt aggcgtaggc
     4801 gtcctcgtcg cggccggtgc cgtcggcctg cccggcgcgg gtgtagagca ggcgggcctg
     4861 gccgaggagg tcgaggccga tgttggccag cgccacctcc tcctccagct cgggcgcacg
     4921 ggtgatccac tcggcgagcc gctgggcgcc gacgagggcg tcgtcggcca gcgccacgca
     4981 ctccgcggcc agtccggcag cgtcgacgcc ctcgggcacg gtggtgtcga cgccgtgcag
     5041 cgggtcctcg aaaccggtgc cgtaggccca gcgggtgtcg tcctcgtgtc cctcggccag
     5101 ggtgaggtag acgtggtcgt cgctcatgcc ctgctcctag atgtggggga cgtcgtcggg
     5161 gatgtcgtag aaggtcgggt gccggtagac cttgtcggcg ctgggggcga agaaggggtc
     5221 cttctcgtcg cgggtggagg cggcgatgtg ctcggagcgc accacccaga tgctcacgcc
     5281 ctcgttgcgc cgggtgtaga ggtcgcgggc gtgggtgagg gccatggcgt cgtcggcggc
     5341 gtgcagcgag ccgacgtgga cgtggttgag gccgcgcttg ccgcgcacga acacctcgta
     5401 cagcggccag ccctgccgct cgggccggtc gtcgctcata ccgccgctcc cttctgcgtg
     5461 cgggccgcct gcttggcggc atgggcggtg gctgcctcgc gcacccaggc gccctcctcg
     5521 tgcgcggtgc gccgccgctc cgtgcgctgg gcgttgcacg gcccgtcgcc cttgatgacg
     5581 cgcgtcagct cgtcccagtc gggggtgccg aagtcgtggt gccccgcctc ctcgttccag
     5641 cgcagctcgg ggtcgggcag ggtgacgccg agcttctcgg cctgcgggac cgtcatgtcg
     5701 acgaagcgcc ggcgcagttc gtcgttgctg tgccgcttga tcttccaggc catcgaccgc
     5761 gccgagttgg gtgaggcgtc gtcgggcggg ccgaacatca tcagtgaggg ccaccaccag
     5821 cggtccacgg cgtcctggac catctcgcgc tgagccgggg tgccgcgcat catcgtcatc
     5881 agcagctcgt agccctgccg ctggtggaag gactcctcct tgcagatgcg caccatcgcg
     5941 cgcgcgtacg gcccgtagga actgcggcac agcggcacct ggttgcagat cgcggcgccg
     6001 tccacgaacc agccgatcac gccgacgtcg gcgaagctca gggtcgggta gttgaagatc
     6061 gacgagtact tctgacgacc ctcgatcagc cgctcggtga ggtcgtcgcg gtccgcgccg
     6121 agggtctcgg ccgccgagta caggtagagc ccgtggccgg cctcgtcctg gaccttggcg
     6181 aacaggatcg ccttgcggcg cagcgacggg gcccgcgtga tccactcgcc ctcgggctgc
     6241 atgccgatga tctccgagtg cgcgtgctgg gcgatctgcc ggatcagcgt cttccggtag
     6301 ccgtccggca tccagtcgcg cggttcgacg cgctggtcgc gcgcgacggt cgcgtcgaag
     6361 tgctcctgga gtccgtccgg cccctgcggg ggcggtgcct cggcggcgtg tgtcgtggtc
     6421 atcgtcacca gcttcccaac cgaccattcg ttcggtatca gtgtgacggg tttccgggcg
     6481 ccgggcaaga ccccggaacc ccgccgcccg cacccttgac agggtgagcg gccggctgga
     6541 ttactgggcc ctgccgcaag ctgaccgaat ggtcggtcgg ggtaccggcc gggatacagg
     6601 gtggtgggag aggtgtcgca ggccgccgag cagacgcccg cggaggtgat gttcgccgcg
     6661 gaccaggctt cccgcgggct gggcatcgag ctggtggagc agggcgcggg atccgcggtg
     6721 gtccggatga ccgtgacccc ggccatggtc aacggccacc ggatcgctca cggcggcttc
     6781 ctgttcctgc tggccgacac cgcgttcgcc tgcgcgtgca acagccacgg ccccgtgacc
     6841 gtcgcggccg gcgccgacat cgtcttcgtc gccccggccc gcgagggcga cgtgctcgtg
     6901 gcccgcgccg aggagcgtgc ccgctacggg cgcagtggga tctacgacgt gagcgtgcgg
     6961 cgcggcgacg aggtgatcgc ggagttccgc ggccgcagcc gcagcgcgcg gggcgacggg
     7021 gacggtcccc gcgcgcggga cgacggtaac ggccaccacg cgcgcgccga cgaggacggc
     7081 cacgaggcac ggcgcgacga gatcacccgc cgcgcgcggg agggcgcggc gcgcgagacg
     7141 ccgggcacga cgacgaagga gtcgcgatga gcagcgagcc gacgaccgaa gccgccccga
     7201 catcccgacg gggcgagccc ctcccccacg acctgctcga cgacgccgag cgcctctcct
     7261 gcgagcaact ccgggagctc cagctcgacc ggctgcgggc gaccctgcgg cacgcgtacg
     7321 acaacgtgga gctgtaccgc aagaagttcg acgccgccgg ggtcgtgccg gacgactgcc
     7381 gcagcctggc ggacctgtcg cggttcccct tcaccaccaa ggccgacctg cgggagacct
     7441 accccttcgg gatgttcgcc gtcccgatgg ccgacgtacg gcgcgtgcac gcctccagcg
     7501 gcaccaccgg ccgcgccacc gtggtcgggt acacggacaa cgacctgtcg gcgtgggcgg
     7561 acgtcgtcgc ccgctcgatc cgggccgcgg gcggccggcc cggccacaag gtgcacgtct
     7621 cctacggcta cggcctgttc accggcggcc tcggcgcgca ctacggcgcc gaacgcgccg
     7681 gttgcaccgt gatccccgcc tccggcggga tgacggcacg ccaggtgcag atcatccagg
     7741 acttccggcc cgagatcatc atggtcacgc cgtcctacat gctcaccctg ctcgacgagt
     7801 tcgaacggca gggcgtcgac ccgcgcacca cctcactcca ggtcggcatc ttcggcgcgg
     7861 agccgtggac cgaggagatg cggcgcgaga tcgaggagcg ggcgggcatc cacgccgtcg
     7921 acatctacgg cctgtccgag gtgatgggcc cgggcgtggc ccaggagtgc gtcgagacca
     7981 aggacggact gcacgtgtgg gaggaccact tctaccccga ggtggtcgac ccgctcacgg
     8041 acgccgtgct gcccgggggc gaggaggggg agctcgtctt cacctccctg accaaggagg
     8101 cgctgcccgt cgtccgctac cgcacgcgcg acctgtcccg gctgctgccg ggcaccgccc
     8161 gccccgcctt ccggcggatg agcaaggtca ccggccgctg tgacgacatg atcatcctgc
     8221 gcggcgtgaa cgtcttcccc acccagatcg aggagatcgt gctgcgcacg cccggcgtgg
     8281 ccccgcactt ccagatccgg ctcaccgcgc gcggccgcat ggaccacctg accgtacgcg
     8341 tggaggcccg ccccgacgcg ggtcccgagc agcgcgaggc cgcagcccgg gcgatcggac
     8401 agagcgtcaa ggacggtgtg ggcgtgagcg tggaggtgga gatcgtggac ccggagacgc
     8461 tggagcgctc cctgggcaaa ctccaccggg tcaaggacct gcgcacggcg tgaaacgtga
     8521 ggacggacac gcctgttcgc tcctcggtcc agtgtgcgag tcggtacgga tgggcaggaa
     8581 gtccatgatc gggggaggtt tgagctttct ggggggaatc ccgtgcgcgt gtgtgtgatc
     8641 ggtgcaggcc tgtcggggct ggcggtggcg cacgccctca aggagcgcgg catctcgttc
     8701 gtctgcctgg agaaggcacc ggacgtcggc gggatctggc gtcagccggg ggccggcgag
     8761 cggggcccgg gctatctgtc gctgcacctc aacaccgcca agcagctgac cggttacgcc
     8821 gacttcccga tgccgtcctc gtatccgctc tacccccggc acagccagtt cgccgcctat
     8881 ctgcgctcct tcgccgagtg ggccggcctg ctcggccacg tcgagctgcg caccgaggcg
     8941 gtctcggtgc gccaggacgc ggacggcggg tggacggtcg tcagccggga cgcggacggc
     9001 gccgagacct cgcgccggtt cgagcaggtg gtcgtcgcct ccggccacca caccgacccg
     9061 gccctgcccg accccctgcc ggccggcgcc gactccttca ccggaacgat tctgcactcg
     9121 ctcgactacc gcgacggcgg cgacttcgac ggacgccgcg tcgtcgtggt gggcctcggc
     9181 gcgtcggcgg tggacatcgc ggcggacctc tcccggcacg ccgagcagac cctgctgtcg
     9241 gtgcggcgcg ggctgcacat cgtgcccaag cagctcttcg ggatgtcggt cgacgagatc
     9301 gccgaggccc cgtggtggac cgagatgtcc ttcgccgagc agcgccggtg ggtggagcag
     9361 gccctgctcg tcgcccgcgg caggctcggg gactacggcc tgcccgagcc ggaccacccg
     9421 gtgttctcgt ccgcgaccac cctctcggac gagatcctca gccggatccg gcacggcgcc
     9481 gtgacgccga agcccgcgat cggctcgttc gacggcgacc gggtcgtctt caccgacggc
     9541 acctccgtga ccgcggacgc ggtcgtctac tgcaccggct tccgcatgac cttccccttc
     9601 ctgcccgcgg gctgcccggt ggcggcggac ggctcggtcg cgctgtaccg cagggtcgtc
     9661 ccggccgacc gtccgggtct gtacttcgtg ggtctggtcc gcccggtggg ctcgatcacc
     9721 cggctggtgg aggcccaggc ccagtgggtg gcgcggctcg tcgacggcga ggcggaactg
     9781 ccggccgccg gggagatgcg cgaggagatc gccacgtacc tcaccggcat cgtccagcgg
     9841 tacggccggg cgccgggcgc ctccgtccag gtcgacgtgg gtccgtacct ggcggagttc
     9901 cgggagtccc tccccgtcta gcgggtccgc gccgtgcgct tcaccgctcg ggctcccggt
     9961 gccgtcgacc gggagccctg ccgtgtccgg acgggcccgc tcagcccacc ggcatcgccg
    10021 tgggagcgct cccgccgacc gcgggcctga ccgcgtacgc ctccgcggag aggtacgcgg
    10081 tcacccgcgg cgggtggccc tgctggtggg ccagcgccag gtaggcgacg agtcccgcgc
    10141 cgtcctcgag gcgccgtccg gtgacggcgg ccagggcacg gacgaggacc gaggggtcca
    10201 tgccgtggtg ccgcagcacg cgcgccgccc gcgcgagggc ctccccgtcg tggcggacgt
    10261 agtcccggac ggggatgtgc agggtgaatc cgctcggccg gacgtcggcg gtgtcggtga
    10321 aggagtggca ggacagggcg ggccgccggc cgaggcccgc cacgtcggga ccgagggccg
    10381 cggcggcgcg gaagaacccc tcgatcgcgg cgggccccgg accccggtcc gttcgggaca
    10441 gccgcccggc ccgccccgcc gtgaggttgt cgtgccgcac gtagaccttc acccggggct
    10501 gcgcccactc ccccagatcc agggcgagga acgggtaccc ggcgccctgg ggcagggcgg
    10561 cgaaggcccg ccggtggccg agccggtgca gcgcctcgcg caccgtcgcg gcggaacgtt
    10621 ccgccccgtt ggccgccggg ttcaggtaga ccttgacgcc gggtacaccg ccgggcctga
    10681 gctccagcgc gcaccacagg gccagcggcc cccggggacc ggagggcagg aacagttcct
    10741 cgatctcgtc cagtgcgtcg gtggtgaagt gccagcgtcg cgccatccgc cgcaccgcct
    10801 ccagtccgac gcggccgttg cgggccaggc tgtctgcgcc gcagcccggt tccaggagca
    10861 ctcgcagggc gggcgccgcg tcgggccgga aggagaggga gtactcgacg ggggtgtggt
    10921 cgtcggagag gaaggtacgg gtgggcgggg gcagactcaa cggccgtgcg gccaccgggc
    10981 ccagcgagtc ggtcagcacc cgtacgtagg ccgcggtgtc cgtcgcggag agtccggcga
    11041 cggccgcgag ccttcgcaac tgcccgcccg tgagggcccc gagtgtcggt gtgtcccgcg
    11101 gatcggcgcc cgtcggtgcg gcggtcaccg gcccgtcccc ggtcggagcc ggacaaagcg
    11161 atacccgcct ggcgaggcgg gtatcggggt tctctgcggc cggaaagcgg cgttcgtgga
    11221 tatgtggtcc acgacacctc cttttactcg taagcaactt gaatgccgcg ttgctcacta
    11281 cccgtgccgt tcaaacttca tgcgaggggt acgggttggg gagatgttgc ggaggtcacc
    11341 gcgtgagcca gttgaggaac tggctccaca tgccggcgcg ttcggccggc cgggccgggg
    11401 cggccgcctt ctcctgctcg gccgccggag ccgggcgggg ctcggtgcgc cgcacggagc
    11461 ggacgggggt gaaccgggcc gggagcgtgg ccagggcccg gttgaagggg cccggacgcc
    11521 aggccaggct gtcctcgggg acggcgagcg cgacgtcggg cagttcgttg agcaggtgct
    11581 cgatggccgt gacggtgatg tgccgggccg gctccttgga ggggcaggcg tgcggacccg
    11641 cgctccaggc caggtgggcc cggttgctgc cggcctggcg cgaggccctg agggccggcc
    11701 cggtgttggc cgcggcgaag ctcaccagga cgaggtcgcc cgcctggagc tgctgcccgg
    11761 cgaactccgt gtcggcggcc gggtagtgcg gcgcgtagtt ggacatcggc gggttctccc
    11821 acagcgtgtc gtcgagcgcc tcgtcgatca ggcctccctc acgggcgtac cgctcgtggg
    11881 tgaggagccg gtgcagggtg ttgccgacga ggttgcgcag gggttcggca cccgcgccga
    11941 ggagcagggc gagctggtgg accatctcct cgtcgtcgag ccccgcctcg tggcgcatca
    12001 gccaggaggt gacgtcgtca ccgggcttct cccgcttgag cgccacgagt tccccgaccg
    12061 cctggaagag cacctcggtg gccttctcgg cgttcactcc gtcgaacatg ccggagatgc
    12121 cgaacagcac ccggtccccg atgtccgcgg ggcagccgaa gagttcgttg aacacgaaca
    12181 gtggcagctg cttggcgtag tccccgagca ggtcggcgga gccgcgggcg gcgaactgcg
    12241 agatgaggta gcgggagatc tgctcggtgc tccggctcag ccgccgggtg tcgacccgcg
    12301 ccatgctgtc ggtgacggcc tggcggagcc tgaggtggtc ggcgccgtcg gcgaacatgc
    12361 agttgggccg gtacgcgagc aggggcgcga ccgggctgtc cgggcccacc ttgccctcgt
    12421 tgaaggcccg ccagcggcgg gcgtccttgc ggaaggaacc ggagtcctgc agcagctgga
    12481 gcgccgccgt gtagtccgtg accagcgtgg cctcgacgcc gggggccagc tcgacggggg
    12541 ccgcggcccc gtagtggcgc aggtactcgt agtacgcctg cggatcggcg gcgaactccg
    12601 gtccgtgcaa cggcacccgg gcgccggatc cgtgggccgg gcagccgggc ggcggcaccg
    12661 gcgcggggtc gtgggcgttc atgtctgctc ccagctccta ggctctgtcc agcagatggc
    12721 ggacgagggt ggtcagtgcg gcggccgagg acttctcgtc gcgggcgtcg caggtgacga
    12781 cgggggtgtc gtcgagcagg tcgagcgcct cgcgcagcgc ccgttcgtcg cgcgccggcg
    12841 cgccgtcgaa gtggttgacg gcgatggcgt agtcgagtcc gtagtgctcg atgaggtcga
    12901 tcaccgggaa ggagtccgcg agccgctcgg ggtcgaccag gacgagggcg ccgagcgcgc
    12961 cgcgggccat gtcctcccac atctgcacga aacgctgctg gccgggggta ccgaacaggt
    13021 agagcacgat gcggtcgctg atggtgaggc ggccgaagtc catggcgacc gtggtggtgg
    13081 tcttgccctt cacgcccttg aggtcgtcga ccggctcggc ggcctgcgtc atcgtctcct
    13141 cggtggacag cggctcgatc tcggagatgg agccgatgag ggtggtcttg cccaccgcga
    13201 agtgtccgac gacgaggatc ttgaccgcgg tctgggtcgc tccctcgcgc acgtagtccc
    13261 gctcatccaa acttggcgcg gagcccattg agcacctcct ccaggatctc cctgtccgcg
    13321 aggcgggcgc gggccaccgg cggacgggtc aggaggtgcc cgccctccat cagggacgcc
    13381 agcaggatcc gcaccacgcc cagcgggaag tgggtgtgcc cggcgatctc ggcgaccgag
    13441 aggtagccgg cggaacacag gtcgagcagg ctctgctcct cgggggagag ccgggcgggc
    13501 cgccgcgtgt cctcggcgga cgcggtgacc agggtgagga gcgagagggc ctcctcgtcg
    13561 ggcaggttgc ggcccttggt gatgacgtag ggacgtacta atgcggcgga ctcgggcgtc
    13621 cagccgtcgc ggccggtcat gagcgggcgc cgaggttctc gcgcggcggt gtcgtcagcc
    13681 gcttgccgag ctgggcgacg agttgctgca tgcggaaggt gatgtcggcc atgtccacct
    13741 ccggggaggc ggagacgccg agataagcgc cctccccggc ggagatcagg aagacccagc
    13801 cgccgtcgaa ctcgacgagg gtctggcgcc agttctggcc cgggtcctca cagaagaagg
    13861 agagggtgcg gctgagcgac tgcacgccgc tcatcgcggc ggccacccgg tcggcgtcgt
    13921 ccttgtcgaa gtcctgcgtc cgggccatca gcaggccgtc ggcggatatc aggaccgcgt
    13981 gcagggcccc cggaatctcc agggcgctgt cgagcatcca tgacagatcg tcgttcacga
    14041 gacctcatgt ccttcactgc ttgcaccagg tgtgctgctc gtccggtcgg cgttctcggc
    14101 gttctccggc tcggtgcccc ggccggagcg cgttccgcgt tggaaggcgc ccatgacccg
    14161 ggcctgctcg gagtcggagc gtccggccgg ccgcggggcg gaggcactgc cgggcacgat
    14221 ggccatcggc cgcttgcggc gccgccgggg cagaccgtcg tcggtccggg aggcggcggg
    14281 cgcggcctcc ggtccgccgt ccgggaccgg ccgggcggtg gggcggtcgg ccggtgcggg
    14341 cgctctcttc tccggcatgg cggtgagcat gtcgtgcggc agcagaacca ccgcccgtac
    14401 gcctccgtag ggagaggagg agtccaccga cacctcgaac ccgaagcgct cgcacagcag
    14461 gccgatgacg gcgaagccga actgcggcgg gttgccgaga gccgccacgc ccgaggcgcg
    14521 ctcggtggcg agcagcttgt cggcgcgcgc ccgttcctcg tcgctcatgc cgacgccggc
    14581 gtcgtccacg accacgcaga tgcccttggg cacggtgcgg atgttgatct ccacgacggt
    14641 gtccgggctg gagtagctgg tggcgttgtc gagcagttcg gcgagggcca gcgccacggg
    14701 ctcgacggcg cggctggtga tgccgaagtc gacccgggag aggatgtcca cccggcggaa
    14761 gtgccggatg cgtccctgcg cgctgcggac cacgtcgtac accgaggcgg tgtcgcgccg
    14821 accgcccagc cagccgtcgc acaggaccgc gacggactgc gcgcgccggc cgaactgcga
    14881 gttggtgtgg tcgatctcca gcaggtcctc cagcagggcc gattcgccgt acttgctctg
    14941 cagccgggag agcaccagct gctgttcggc ggcgaggccc tggagagtcc gcatggccga
    15001 tttcagcacg gtcttcgtct cgtcctcggc ccgctcctga gcggcctgca cggatttccc
    15061 gtagttgttc tccagctggg tgtagcggtc ccggagcccc tggacctgct gccgcaacgc
    15121 ccgggccgcc ctgcgctggc ggctgacgag cacggcggcg gcgacgaggg cgacgagcag
    15181 gacccagagc aatgggtttg ccgtgtattc cgtcataaga ctctcttcag gcgacttacg
    15241 gccggtttgc tgcgttccgg atccacgcgg gcggtccggc ggactgccgg cgcccgggtg
    15301 gccgtccggg ctgtccttga agtcggggat gccgtctttc acccatccgc ccgctctgca
    15361 aacccggtga tcgtatcacc gcatgatcag gtgaattaac gtcaaagaac gcccatcacg
    15421 gaccggttga gaccgggggt cgggcccgcc ggagcggtgg gtacagtcgg gcccgtgaga
    15481 gacgcacaag gcacgttccg gctgagtaca ggcccggcgc gcggcggcac ggggtgacgc
    15541 ccgaggccat ggccgcggtc ttcgcagcgg gcgtcggagc cggcgccatc aacagcgtcg
    15601 tcggctccgg aaccctgatc accttccccg tactgctggc cacgggactg tcgccggtga
    15661 ccgcgacggt gtccaacgcg ctgggtctga tccccggctc catcagcggt gccatcggct
    15721 accgcaagga gctgaccggc cagcgccgac gcgtcctgaa gctgggcgcc ggggccctgc
    15781 tcggcggcct ggcaggcgcc acactgctgc tgtcgctgcc gccggacgcc ttcgagacga
    15841 tcgtgccggt actggtgggc ctcgccctgg tgctggtggc gttccagccg cagatcggcc
    15901 ggctggtgca gcgccgccgg gagcgcaccg gtgcctctcc ccgccgggac ggcggtccgc
    15961 tgctcctcgt cggcctgacc ctcgccagcg tgtacggcgg ctacttcacc gccgcccagg
    16021 ggatcatcta cctgtccctg atgggcatgc tcctcgacga acccatgcaa cgcctcaacg
    16081 gcgtcaagaa cgtcctctcc gccgtcgtca acaccgtcgc cgccctcttc ttcctcttcg
    16141 ccgcggactt cgactggacc gccgtcggac tgctcgcggt cggctcggcc ctgggtggct
    16201 ggttcggcgc caaggtgggc cgacgtttca gccccctggt tctgcggata ctggtggtga
    16261 cggtcggcac ggtcgccctg gcgcagctgc tgctgcgcta gccaggggcc accggtgtcg
    16321 ggggcgggcg ggagtggaat ctgcccaacc gcctccccgg ccaatcattt ccggccatcc
    16381 gggacacgtg ggaaatgcca cgttccgtgg ccgattgacc ccggtagcga tcagggaagc
    16441 catggagcgc ccgtgatcga tgcgaaggga cagaccccac cgtgacgctc gtagcgcctc
    16501 cccccatacc cagggcagcg ggttcgctgc cgttcctggg ccacgcggta cagctcatgc
    16561 gcgacaacct cggcttcgtc gccgcgctgc gcaccaccta cggccccctg gtcgagatca
    16621 ccctccagcc cggcacccgc accctcgtcg tgcaggatcc cggcctcatc cgcaccatgc
    16681 tgaccgacct gggaccgagc ctcgacaagg gccggttctt cgagaagatg ggacagctgc
    16741 tcggcgactc cgtcgtcacc gcggccggcc aggtccacgt ccgcaagaga cgccagctgc
    16801 aacccgcctt cgcccgcgag caaatcgccc ggtacgtcga caccatgcgc gccgagacgg
    16861 acgccgccgt cgacgagtgg gtccccggcc ggccgctgga cgtccgcgag gccatggtcg
    16921 ggctcagcct gaacatgctg gccaagacga tcttctcggg cagtctcgac gacgccacgt
    16981 tccgccggct gcgcgccgac ctgtcggtcg tgatgaacgg cgtgggcgcc cgcgtcatgc
    17041 tgcccgactg ggtcgagcgg ctcccgctgc ccgccaaccg ccgcttcaac gcggcgcgcg
    17101 acggcgtgcg ggccaccatc gaacgcgccg tgagcgacct ccaggactcc ggccacgaca
    17161 ccggtgacat gctctcgctg ctgctgcgca cgaccgacga ggagaccgga gaaccgctga
    17221 ccggccacca gatctcctcc gagatcctca ccctggccgt cgccggcacc gagaccaccg
    17281 cctcggtcct gtcctggatg ctgtacgaac tcgcccgcaa cccggaggtc gaggcacggg
    17341 tcctggagga gctcgacgag gtcctcggcg accggccggt ggccttcgac gacctcggcc
    17401 ggctgccgta cctgggccgg gtggtggagg agacgctgcg gatgcaccac accgggtggc
    17461 tcgtcacccg gcgcaccgtc accgagaccc ggctcggccc ctggacggtg cccccaggca
    17521 ccgaactcgc ctactgccag cacgccctgc accgcgaccc gctgctgttc cgcgacccgc
    17581 tggagttcga ccccgaccgc tggctggacg acccggggcc gcggcccacg caggggttcc
    17641 tgcccttcgg cgccggcaag cacaagtgca tcggcgaccg gttcgcgttc accgaactcg
    17701 tcaccgccgt cgccaccatc gtgcggcggg tacggctgga gctcgcgccc ggccagacgg
    17761 tgcgccccgt cgccgcggcc acggtccggc cccgcaccct gctgatgacc gtccgcgaga
    17821 aggaggggca ggaggcatag ggggcagagg ggagaacagg ggagaagaga gcggcagcgg
    17881 ccgggcgtcc aggaaccgga cggtccggca ggcatgtggt ggatacatct actgtgcacg
    17941 gtgaccgagg acgtcccgta cgaaggagtc acggcatgac cggccggacc gccagctccc
    18001 ccacgcccga ccacgacgac gacgtgctcc ggctccagga cgtgagcgtc cgccgcctca
    18061 ccacggacca gctgatcctg gacggcgtcg actggtcggt ccgcccgggc gagcactggg
    18121 ccctgctggg ggccaacggc gccgggaaga cgaccctgct gcggctgctc ggcgcgctca
    18181 tgcaccccac gaccggcacg gtcgaggtgc tcggcagccg gctcggccgg gtcgacgtgc
    18241 gggagctgcg ggcgcgcatc ggccatgtga actccgccca gcgggtgccg caggacctca
    18301 ccgcgcacgc ggtcgtgctg accggccaca gcggcacggt ccagccgctg tggcggacgt
    18361 acgacgacga ggtgcgggag cgggcccgcg acctgctgac cgagctgggc gtcaaggagc
    18421 tggcggaccg gccctacggc gtctgctcgg gcggtcagcg ggcgcggatc ctcatcgcca
    18481 gggcgctgat ggccgacccg gcgctgctcc tcctggacga gcccttcaac gccctggacc
    18541 tgccgtcccg ggaggacctc gtcgaggcga tgcaccagct gaccgagggg cgcccccggc
    18601 tggccacggt gacggtcacc caccacctgg aggagctgtt cccggccgtc agccacaccc
    18661 tgctgctgcg cgagggccgg atcctgtccc gtgggccggt ggacgacgtc ctcacggacg
    18721 acctgctgac cgcctgcttc ggccgcgaga tcacggtcgc caggcgcgac ggccgctggt
    18781 cggccttctc cggccggcgc acccggggtt agtcccgccg ccgtcgtcgt tcgccgctgc
    18841 cgtccgaagg ggcggagcgg tcccggacgt gtcggcgtgc ggaacgtccg gggccgcccc
    18901 tcggctcccc cgccggggac tgcccgctcg gcgctccgga caaacggaac gccgcggagg
    18961 ccgggcccgg ttcacgcccg agggtgaccc cggtcaacac acgtccccgt cgagcgcgga
    19021 ccccgcgccc gggacgtccc ggaccgtggt ctcaggcgca gccccaggcc gacattccct
    19081 gcaggccggc caggcgcttc gcgacggcga tctgctcggc gcgggtcgcg aggtccgcgc
    19141 gcggggcgta cttcaggccg ccggccgcgg cccagctcga cggggcgaac tgcaggcccc
    19201 cgtagtagcc gttgccggtg ttcgcctgcc agtcgccgcc cgactcgcag gcagcgatgg
    19261 agtcccagtc cgtgcgcagc gggaccgacg cggaggcggc cgcaccggtg gtcgcggcga
    19321 gtgcggccgc ggcgaggaga gcggccgcgg cggtccggat cgtgcgaccg tgcgagcggc
    19381 gcacgttgcc ctgaagagca tttcgtctac agatcatact tggactgtta ccccacgtga
    19441 gggcgggccg ccgccccgcc cggcgccgcc ctacgccggt cggagcaccc gaaccacccg
    19501 gttcgccgtg gcgtccgcgt cacttcgccg acggcgcgga cggcgcgccg tccgccgccg
    19561 cctccgtggc gaggtagtcc ggcacggcct ccgggtcgac cagacggttg aggcggctgg
    19621 gcacgtcgaa cccgatcagc aggatgacca cgagtgtcag cgagaaggtc agcaccgcaa
    19681 gcgactggcc gagcgacatg gaggaggcca gcctggcccc gagcaccggc gccacggcgc
    19741 cgcccagcgc gccgacgttg taggtgaaac ccagggacgc ggcccgggtc tcggtcggga
    19801 agtgcccggc gatgtacttc ggcagcagcc ccgagatgcc ctgcatgcag gcgagcatca
    19861 ggaacagcag gatgccgagc tgcagttggc tgtcgcggat cgcgaagacg gggaagacga
    19921 aggcgatccc gaccgccagc gtgcacgcgt acgcccggcg ggtgccgaac cggtcgccga
    19981 cgaacccggt gacgatgcag cccgccatcg tgccgaaccc ggcgtagtag agcgcgtcgc
    20041 tgacctgggc gggggtgaag cccagttcgg tcttgaggta ggtgggcagc agggcctgga
    20101 ccggccagct gtagaggaag gcgcagaaca cggtggcgca gagcgccacg aacagcagcc
    20161 accttttgcg cccgcccagc tggaccgcga aggcgacgag gcaggccgtc gccaccacgg
    20221 acaggacggg caccgcaccg gcgccgagcg gagtgaacac cgcgaacagc gagccggtgg
    20281 cgaccaccgc cagcaccgtg ttgacgctcg cccggcgccg ccccgcgaac agcgggcgga
    20341 aggggttggg ccgctcgccg gtggccccca cccgtgcctc ccagtcgtcg gcctcgggca
    20401 gcgaccgccg cacccacagg gcgacgacca cagggaacag cccgatgtag aacagccagc
    20461 gccagccgtg gcccggcacc acgtgctcgt agacctcggc cgccagcacg ccgcccagcg
    20521 agaagccgga gatgaggaat ccggaggcgc ggttgcgcag ccgggcgggc cagctctcca
    20581 gtacgtaggt ggcactggcg ctgtactcgc cggccatgcc catgccgatc agcaggcgcg
    20641 cggtgaacag gctggtgtag tcccaggcga agccgcaggc gaaggtgccg accgagtaca
    20701 gcaggatgct ggccaccatg gcgcttctgc ggccgaagcg gtcgcctagc gcgccgagca
    20761 cggcgccgcc gagccagcgg gtgatgaacg caccggacac caggctcgcg gactcgacgg
    20821 tcgacagtcc gaagtcgtcg gcgatctcgg tcagtacgag ggtgatgagg acgaagtcga
    20881 agccgtcgag gagatagccg atccaggcgg cgaagaagga cttccacttc tgccgggtga
    20941 tctctctgta ccaggggcgg ggcttcgcgg tggtgcgcgc agatgacatg acgggtccaa
    21001 tgcggggtgc ggattcgcgc gtcggggacg gggagcgggc aggaccgggg ccgggcctgc
    21061 ggccccggtc cgcgggtcac aggagaccgg cctcggtgag ccggtcgcgg acccgggcca
    21121 cggcgcgt
//
