LOCUS       NZ_WHZR01000001        21128 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. OM5714 A912_AS4_SC1_R2, whole genome shotgun
            sequence.
ACCESSION   NZ_WHZR01000001
VERSION     NZ_WHZR01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. OM5714
  ORGANISM  Streptomyces sp. OM5714
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M.
  TITLE     Whole Genome Sequence of the phthoxazolin producer Streptomyces sp.
            OM5714
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7915160)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2019) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2017
            Assembly Method                   :: Newbler v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 102.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_010993835.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:48:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,820
            CDSs (total)                      :: 7,730
            Genes (coding)                    :: 7,557
            CDSs (with protein)               :: 7,557
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 7, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 7, 5 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 173
            CDSs (without protein)            :: 173
            Pseudo Genes (ambiguous residues) :: 0 of 173
            Pseudo Genes (frameshifted)       :: 58 of 173
            Pseudo Genes (incomplete)         :: 139 of 173
            Pseudo Genes (internal stop)      :: 18 of 173
            Pseudo Genes (multiple problems)  :: 36 of 173
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7652565
            Orig. end                         :: 7673693
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WHZR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="28"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11128](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            complement(419..1495)
                     /locus_tag="STPH1_RS34225"
                     /old_locus_tag="STPH1_6787"
     CDS             complement(419..1495)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994291.1"
                     /locus_tag="STPH1_RS34225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6787"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_164385993.1"
                     /transl_table=11
                     /translation="MTSRSRMPLFRRFSVVAALALPFVLTSCVTPARSSPDGRDLSNER
                     IPAAVDRDTTLTVGAPDLKVALELSGQIDRLPFKVKWANISGGPQCSEAFRAGALDICS
                     AADIPSINAHWTGLDTKLVAVKFRADPLKNPVYELGTAPGSGIRTLADLRGKKIAYSPG
                     QAQGALVLRILQKAGLTQQDVELVELASTGDVYPTALGNHQVDAAPIADVNIKRYLSHY
                     GKEGGSTIKHGLRDDPAHLWALTESVADAGKSAAVRELVKFWARAQTWIDRHPRQWVAG
                     YYVEDQGLSREDDEYLVRRVGHLDLPADWTGAIHRQQQTIDLLAAEQDREPFDAGLLFD
                     RRYETVAARAVAGEGTSS"
     gene            complement(1698..2537)
                     /locus_tag="STPH1_RS34230"
                     /old_locus_tag="STPH1_6788"
     CDS             complement(1698..2537)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971683.1"
                     /locus_tag="STPH1_RS34230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6788"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_164385994.1"
                     /transl_table=11
                     /translation="MTGQTANSRVNEREADVLRLQDVSVRRFTTDQLILDDVDWTVRPG
                     EHWALLGANGAGKTTLLRLLGALMHPTTGTVEVLGSRLGRVDVRELRARIGHVSTSQRV
                     PQDLTAHAVVLTGHSGTVQPLWRTYDDEVRVRACDLLTELGVKELADRPYGVCSGGQRA
                     RILIARALMADPALLLLDEPFNALDLPSREDLVEAMHQLAEGRPQLATVTVTHHLEELF
                     PAVSHALLLREGRILSRGPVDEVLTDSLLTACFGRDITVARRDGRWSAFSGRRVSGR"
     gene            2746..3816
                     /locus_tag="STPH1_RS34235"
                     /old_locus_tag="STPH1_6789"
     CDS             2746..3816
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388035.1"
                     /locus_tag="STPH1_RS34235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6789"
                     /product="hypothetical protein"
                     /protein_id="WP_164385995.1"
                     /transl_table=11
                     /translation="MGSRGAVRGSGRRRAGRVGVGLAALLVGLLGTGCAAFDTEDDVRR
                     ARELAEESYPGELEVVDARILFPESTGSEVTLAVADDPDAAVRFRIDAAKDRCDGGPNC
                     ADALREAVDRARREAGQLRAMRDAFDGCGHPLLGTDEKLTAPWIEARVTDRTVDDVLAR
                     VGACVQRWVTARAERDPGAAPEWVTVNLAAPGAADDLPEAKSTLPTVVRFTHGRRLAAL
                     AQDPYYVAAYPVGRDADRTVDAAAATLRIVSPFEERQAFSRRIDASVLPALRETYPDAV
                     TAGGAGMGVWRLEQGTVRRMRGYVLFCERPPADGKQCFGDLAALVSSDPAGRDAEVVRI
                     LTDIRDEHGVLRLPPR"
     gene            complement(3857..4585)
                     /locus_tag="STPH1_RS34240"
                     /old_locus_tag="STPH1_6790"
     CDS             complement(3857..4585)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016328090.1"
                     /locus_tag="STPH1_RS34240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6790"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_164385996.1"
                     /transl_table=11
                     /translation="MRTTRLVPTLLAALVAALLSALTLAPSASAVEPRPGDGGPQPIIG
                     GGYAQNAPWAARLFSGGQQTCTSTIISPTWILTAKHCVSGGNLAFRIGSLDQGSGGTVA
                     NGVQTVTSPSADLALVRLDRSVSATYARLGQPGTVRVGQTVQVYGWGATSRCGSEINCQ
                     SQYLKVANVSVTRGCYDAYYGQAICARPVDGITAGGDSGGPMMAGGVQVGVASTSDRQT
                     TTAYTNVTAYRSWIQSVAGV"
     gene            complement(4798..5550)
                     /locus_tag="STPH1_RS34245"
                     /old_locus_tag="STPH1_6791"
     CDS             complement(4798..5550)
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324211.1"
                     /locus_tag="STPH1_RS34245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6791"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_205616786.1"
                     /transl_table=11
                     /translation="MAAVFAAGVGAGAINSVVGSGTLITFPVLLATGLPPVTATVSNAL
                     GLIPGSISGAIGYREELRGQRRRVLKFGAGALLGGLGGATLLLMLPADAFETIVPVLVG
                     LALLLVAFQPQIGRLVQRRRARTGASPRRDGGPLLQTGLALASVYGGYFTAAQGIIYLS
                     LMGMLLDEPLQRLNGVKNVLSALVNTVAALFFLFAADFEWTAVGLLAVGSGLGGWVGAK
                     VGRRFSPTVLRILVVTVGTVALVQLLLR"
     misc_feature    5525..5540
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.25"
                     /tool="antismash"
     gene            5883..7088
                     /locus_tag="STPH1_RS34250"
                     /old_locus_tag="STPH1_6792"
     CDS             5883..7088
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="STPH1_RS34250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6792"
                     /product="sensor histidine kinase"
                     /protein_id="WP_164385998.1"
                     /transl_table=11
                     /translation="MTEYTGNPLLWVALVALVAAAVLISRQRKAARALRQQVQGLRDHY
                     TELESDYGKSVQAAQERAEDETKTVLKSAMRTLQGLAAEQQLVLSRLQTKYGDSALLQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGGRRDTASVYDVVRSAQGRIRHFRRVDILSQVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINIRTVPKGICVVVDDAGVGMSDEER
                     ARADKLLATERASGVAGLGNPPQFGFAVIGLLCERFGFEVSVDSSSPYGGVRAVVLLPH
                     ELLTAMPEKKAPAAAPAARGTARPVPDGGPEAALTSSQTGDGLPRRRRKRPMAIVPGSA
                     SSPRAAGRSDSEQAQVMGAFQRGTQSGRVTEQDRADRTDRPDSAGRTSDTPGASSEGHE
                     VS"
     gene            7085..7486
                     /locus_tag="STPH1_RS34255"
                     /old_locus_tag="STPH1_6793"
     CDS             7085..7486
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="STPH1_RS34255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6793"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_007388033.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDFDKDDADRV
                     AAAMSGVQSLSRTLAFFCEDAGQSWRQTLVEFDGGWVFLISAGEGAYLGVSASPEVDMA
                     DITFRMQQLVAQLGKRLTTPPRENLGARS"
     gene            7483..7860
                     /locus_tag="STPH1_RS34260"
                     /old_locus_tag="STPH1_6794"
     CDS             7483..7860
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="STPH1_RS34260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6794"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_007388032.1"
                     /transl_table=11
                     /translation="MTGHDGWQPEAPELVRPYVITKGRGLPDEDDLSLITLVTASDGQQ
                     QRPARLSPEEQSLLDLCAAGYLSVAEIAGHTHFPLGVVRILLASLMEGGHLTTRPPVAR
                     ARLADREILEEVLNGLRAKFG"
     misc_feature    7522..7524
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7835..8428
                     /locus_tag="STPH1_RS34265"
                     /old_locus_tag="STPH1_6795"
     CDS             7835..8428
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="STPH1_RS34265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6795"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_108989779.1"
                     /transl_table=11
                     /translation="MGSAPSLDERDYVREGATQTAVKILVVGHFAVGKTTLIGSISEIE
                     PLSTEETMTQAAEPVDDLKGVQGKTTTTVAMDFGRLTISDRVVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFPVIDLIEHYGLDYAIAVNHFDGTPLRDERALREALD
                     LLDDTPVVTCDARDEKSSAAALTTLVRYLLDRTR"
     misc_feature    8440..8451
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            8444..9793
                     /locus_tag="STPH1_RS34270"
                     /old_locus_tag="STPH1_6796"
     CDS             8444..9793
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972616.1"
                     /locus_tag="STPH1_RS34270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6796"
                     /product="cytochrome P450"
                     /protein_id="WP_153181388.1"
                     /transl_table=11
                     /translation="MNAHDTAPVPPPGCPAHGSGARVPLHGPEFAADPQAYYEHLRHYG
                     AAAPVELAPGVEATLVTDYAAALQLLQDSGTFRKDARRWRAFNEGRISPDSPVAPLLAY
                     RPNCMFADGADHLRLRQAVTDSMARVDTRRLSRSTEQISGYLISQFANRGSADLLGDYA
                     KQLPLFVFNELFGCPADIGDRVLFGISGMFDGVNAEKATAVLFQAVGELVALKRRKPGD
                     DVTSWLMRHEAGLDDEEMVHQLALLLGAGAEPLRNLLGNTLHRLLTHERYAREGGLIDE
                     ALDDTLWENPPMANYAPHYPAADTELAGQQLRAGDLVLVSFAAANTGPALSASREAGSN
                     RAHLAWSAGPHACPSKEPARHITVTAVEHLLNELPDVELAVPEDSLTWRPGPFNRALAT
                     LPARFTPVRSARRAEPGQAAAAAEREQTANTARPAEHKGMWSQFLNWLTR"
     misc_feature    9864..9878
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    9966..9983
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     misc_feature    complement(9990..10005)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            10001..11128
                     /locus_tag="STPH1_RS34275"
                     /old_locus_tag="STPH1_6797"
     CDS             10001..11128
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388029.1"
                     /locus_tag="STPH1_RS34275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6797"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_164385999.1"
                     /sec_met_domain="indole_PTase (E-value: 4.8e-148, bitscore:
                     491.5, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPTGTDPRHTPTLGSLTGGQLRRLGAVAGLSRADVETYAQVL
                     TESLGPAAERPLSLPPPTRTFLSDDHTPVEFSLSFRPDAAPSVRVLVEPGCGADSLARN
                     GRVGLEAIRAMARRWHFATDVLDELRDLFLPPDPQGPLALWCALELRPGGVPKVKVYLN
                     PAAGGEERSAATVREALRRLGHRQAYDGLPRGAGHPFLALDLGDWAEPRVKVYVRHENL
                     SAGQAGRLSRMDSGPGPAAVEGFFRTAAGLGPDATGLGGRPGLSCHSFTDTTTARPSGF
                     TLHIPVRDYVRHDGEALARASRVLRHHGMDASVLDRALAALTERRPEDGVGLIAYLALA
                     HQRDQAPRITAYLSSEAYAVRPPAVETVGRPVPVS"
     gene            complement(11238..12536)
                     /locus_tag="STPH1_RS34280"
                     /old_locus_tag="STPH1_6798"
     CDS             complement(11238..12536)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971674.1"
                     /locus_tag="STPH1_RS34280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6798"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_164386000.1"
                     /sec_met_domain="FMO-like (E-value: 4.5e-81, bitscore:
                     271.5, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-09, bitscore:
                     36.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLAMGHALKERGISFVCLEKAPDVGGIWRQPGAG
                     ERGPGYQTLHLNTAKQLTGYADFPMPESYPLYPRHSQVAAYLRSFAEWAGLLGHVELRT
                     EVVSVRQDADGLWTVVSRGADGARTSRRFDQVVVASGHHTDPALPDPLPAGADSFAGTI
                     LHSLDYRDGSDFAGRRVVVVGLGASAVDIAADLSRHAERTLLSVRRGLHIVPKQLFGMS
                     VDEIAEAPWWNEMSFEERRKWVEQALLVARGRLSDYGLPEPDHPVFSSATTLSDEILSR
                     IRHGAVTPKPAIASFDGDRVVFTDGSSEPADAVVYCTGFHMTFPFLPAGCPVAADGSVE
                     LYRRVVPADRPGLYFVGLVRPVGAITRLVEAQAEWVARLIDGAAALPAAEEMREEIGTY
                     LTGIVQRYGRTEGASIQVDVGPYLAGFRESLPV"
     gene            complement(12648..13994)
                     /gene="paaK"
                     /locus_tag="STPH1_RS34285"
                     /old_locus_tag="STPH1_6799"
     CDS             complement(12648..13994)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (99-352). E-value: 9.2e-21.
                     Score: 65.8. Matches aSDomain:
                     nrpspksdomains_STPH1_RS34285_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971673.1"
                     /locus_tag="STPH1_RS34285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6799"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_153181391.1"
                     /sec_met_domain="AMP-binding (E-value: 3e-25, bitscore:
                     87.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPTTGAAPAPRPGEPLPHDLLDDAERLSREQLRELQLDRLRA
                     TLRHAYDNVELYRKKFDAAGVTPEDCRSLADLSRFPFTTKADLRDTYPFGMFAVPMSDV
                     RRVHASSGTTGRATVVGYTENDLSMWADVIARSIRAAGGRPGHKVHISYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLDEFERQGIDPRGS
                     SLRVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGVAQECVETKDGLHIWEDH
                     FYPEVVDPLTDAVLPEGEEGEVVFTSLTKEALPVIRYRTRDLTRLLPGTARPAFRRMRK
                     VTGRCDDMIILRGVNVFPTQVEEIVLRTPGVAPHFQIRLTERGRMDHMTVRVEARPDAG
                     PERREAAARAIAQGVKDGVGVSVEVEVVEPETLERSLGKIRRVWDLRGA"
     CDS_motif       complement(12909..12971)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STPH1_RS34285_0001"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="STPH1_RS34285"
                     /protein_end="362"
                     /protein_start="341"
                     /score="12.7"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQVE"
     aSDomain        complement(12939..13697)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STPH1_RS34285_AMP-binding.1"
                     /evalue="9.20E-21"
                     /label="STPH1_RS34285_AMP-binding.1"
                     /locus_tag="STPH1_RS34285"
                     /protein_end="352"
                     /protein_start="99"
                     /score="65.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="PMSDVRRVHASSGTTGRATVVGYTENDLSMWADVIARSIRAAGGR
                     PGHKVHISYGYGLFTGGLGAHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPS
                     YMLTLLDEFERQGIDPRGSSLRVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGP
                     GVAQECVETKDGLHIWEDHFYPEVVDPLTDAVLPEGEEGEVVFTSLTKEALPVIRYRTR
                     DLTRLLPGTARPAFRRMRKVTGRCDDMIILR"
     gene            complement(13991..14404)
                     /gene="paaI"
                     /locus_tag="STPH1_RS34290"
                     /old_locus_tag="STPH1_6800"
     CDS             complement(13991..14404)
                     /EC_number="3.1.2.-"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971672.1"
                     /locus_tag="STPH1_RS34290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6800"
                     /product="hydroxyphenylacetyl-CoA thioesterase PaaI"
                     /protein_id="WP_164386607.1"
                     /transl_table=11
                     /translation="MFAADEASRGLGIELVEHGAGTAVARMTVTPAMVNGHRIAHGGFL
                     FLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVARAEERARFGRSGIYDVSVW
                     RGDELIAEFRGRSRSARDDTAREAPGTTTKESR"
     misc_feature    complement(14465..14480)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.71"
                     /tool="antismash"
     misc_feature    complement(14586..14599)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            14618..15604
                     /gene="paaA"
                     /locus_tag="STPH1_RS34295"
                     /old_locus_tag="STPH1_6801"
     CDS             14618..15604
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031683.1"
                     /locus_tag="STPH1_RS34295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6801"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_164386001.1"
                     /transl_table=11
                     /translation="MTTTHAAEAPPPDAPDGLQEHFDATIARDQRVEPRDWMPDGYRKT
                     LIRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RDDLTERLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTDAQREMVQDAVDRWWWPSLMMFGPPDDASPNSAR
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEESGHHDFGTPDWDELMR
                     VIKGDGPCNDRRMERRRTAHEEGAWVREAATAHAAKQAARAEKGAAA"
     gene            15601..15912
                     /gene="paaB"
                     /locus_tag="STPH1_RS34300"
                     /old_locus_tag="STPH1_6802"
     CDS             15601..15912
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971670.1"
                     /locus_tag="STPH1_RS34300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6802"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_164386002.1"
                     /transl_table=11
                     /translation="MTPEKAQQPDKRGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALT
                     HARDLYTRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPDDVPHI"
     gene            15922..16749
                     /gene="paaC"
                     /locus_tag="STPH1_RS34305"
                     /old_locus_tag="STPH1_6803"
     CDS             15922..16749
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326306.1"
                     /locus_tag="STPH1_RS34305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6803"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_164386003.1"
                     /transl_table=11
                     /translation="MSDDHVYLTLAEGHEDDTRWAYGTGFEDPLHGVDTTVPEGVDARA
                     LAAECVALADDALVSAQRLAEWVTRAPELEEEVALANIGLDLLGQARLLYSRAGQADGT
                     GRDEDAYAYFRDADDFRNVRLAELPGGDFAFAVVRLLVLSSWRLAHFRRLEAHPDPVLA
                     AVAAKGVKELTYHRQYAAEWCVRLGDGTDESHRRTRAALDEVAPYLGELHTAYDVRDEV
                     AEDLRQVTGAAGLTLPVHRPLPGSGRAGEHTEHLAPLLTELQGVARAHPEATW"
     gene            16743..17258
                     /gene="paaD"
                     /locus_tag="STPH1_RS34310"
                     /old_locus_tag="STPH1_6804"
     CDS             16743..17258
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388025.1"
                     /locus_tag="STPH1_RS34310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6804"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /protein_id="WP_164386004.1"
                     /transl_table=11
                     /translation="MVTGGPALLDAHRARHVAEQVPDPELPMLTLADLGVLRDVEVTGD
                     GTVVASLTPTYSGCPAMAEMRADVAARLRDAGYPRVEIRTVLDPPWTSDWITESGRLKL
                     TEHGIAPPGAAPRGPVSLVLSPIRPAVPCPRCGSADTEETSRFAATSCKALWRCRACRE
                     PFEYVKEI"
     gene            17259..18365
                     /gene="paaE"
                     /locus_tag="STPH1_RS34315"
                     /old_locus_tag="STPH1_6805"
     CDS             17259..18365
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388024.1"
                     /locus_tag="STPH1_RS34315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6805"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_164386005.1"
                     /transl_table=11
                     /translation="MAPTAPVPAAPVRTRRRPAFHALRVAAVERLCADAAAVSFEIPDE
                     LAGEFAFAPGQSLTLRREVDGRDERRSYSICAPAGSAPRIGVRVVPGGLFSAWLVEDVR
                     PGDTVQVMAPTGLFTPDLSAPGHHVLIAAGSGITPMVSIAESVLAADDRSSVTLFYGNR
                     RSDTVMFADELADLKDLHPTRFHLAHVLSREPREAEVLSGRLDAARLSALIDSLLDVES
                     ADHWWLCGPQGMVADAQQVLTGLGVPAERVHRELFYADDEPVREVRHEESGPEGPVSEV
                     TVVLDGRSTTAPLSRERSVLDGAQQTRPDLPFACKGGVCGTCRALVTDGSVDMRRNYAL
                     EVAEVDAGYVLTCQSYPVSEKLTVDYDS"
     gene            complement(18388..19605)
                     /locus_tag="STPH1_RS34320"
                     /old_locus_tag="STPH1_6806"
     CDS             complement(18388..19605)
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971665.1"
                     /locus_tag="STPH1_RS34320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STPH1_6806"
                     /product="alginate lyase family protein"
                     /protein_id="WP_164386006.1"
                     /transl_table=11
                     /translation="MSSAPTRRHRRSRAALLATLTAALVGTLLAGPGPAAPRADAAPAA
                     FTHPGVTVSQGQLDFVRAKVAAGAQPWKGAFDQLTASRYADPNRTPKPRAVVECGSYSN
                     PNHGCTDEREDAIAAYTNALAWYLTRDERYARKSIELMDAWSAVLRDHTDSNAPLQTGW
                     AGSSWPKAAEIIKYTYGGNWADSGRFATMLRDVYLPEIINGSNSNGNWELTMTEAAVGI
                     SVFLEDRASYDRAMARFRTRTAAYVYLESDGALPKTVPSQHLDTRDKIVRYWQGQSTFV
                     TGLTQETCRDLTHTGYGIASISHVAETSRIQGQDLYGTDVGERLRHALGFQAKYEQGAA
                     APDWLCGGELDLGLGPVTEVGYNAMHNRLGFAMTNTQALTERTRPSGTNNLFVAWETLT
                     HGDNPA"
     misc_feature    19627..19638
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    19639..19653
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    19675..19690
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.74"
                     /tool="antismash"
ORIGIN
        1 gggatcaagg ccagggaggg aatggaccgc ttgatctgca ccggcccgtc gatcagggcc
       61 tcgccgatcc ggctgagacc ggacacgagc gcgagcacca gtccggccgc cacgccgaac
      121 agcaggccca gcagggcgcg ttgggcggag gtgccgaggt gagactggag ttttccgctg
      181 tcgatgagat cgcccgcggt gccggcgacg gtccacggcg cgggcagact gcgcacgtcg
      241 aagaggccga gtgccgagcc tgccgcccac agcgcgagca gcagcaccgg gccgatcacc
      301 cagccgtacg ggacgggcct gccggggccc ggaagcccgc ggcgtgagcg tcgggggcgg
      361 accgcgaccg gtgggggcgg cgtcgcctcg ggtgcctgct tctcgaaggt ggtggtgctc
      421 atgacgacgt cccctccccg gcgacggccc gcgcggccac cgtctcgtaa cggcggtcga
      481 agagcaggcc cgcgtcgaag ggttcgcggt cctgttcggc ggccagcagg tcgatggtct
      541 gctgctgccg gtggatggcc ccggtccagt cggccggcag gtccagatga ccgacgcgtc
      601 gcacgaggta ttcgtcgtcc tcgcggctga ggccctggtc ctccacgtaa tagcccgcca
      661 cccattgcct ggggtgccgg tcgatccatg tctgcgcacg cgcccagaac ttcacgagtt
      721 cacggacggc ggccgacttg ccggcgtcgg cgacggattc ggtcagcgcc cacagatggg
      781 ccggatcgtc ccggagaccg tgcttgatcg tcgagccgcc ctcctttccg tagtgtgaga
      841 gatagcgctt gatgttgacg tcggcgatgg gcgcggcgtc cacctggtgg ttccccagcg
      901 ccgtgggata gacgtcgccg gtgctggcga gttcgacgag ttcgacgtcc tgctgggtga
      961 gtccggcctt ctggaggatg cgcagcacca gcgcgccctg cgcctgtccc gggctgtagg
     1021 cgatcttctt cccgcgcagg tccgcgaggg tcctgatgcc ggagcccggt gccgtgccca
     1081 gttcgtagac gggattcttg agggggtccg cgcggaactt caccgccacg agcttcgtgt
     1141 cgaggcccgt ccagtgcgcg ttgatcgacg ggatgtccgc ggccgagcag atgtcgaggg
     1201 cgccggcgcg gaaggcctcg gagcactgtg ggccaccgct gatgttggcc cacttcacct
     1261 tgaaggggag ccggtcgatc tgccccgaca gttcgagggc gaccttgagg tcgggcgcgc
     1321 cgaccgtgag cgtggtgtcg cggtcgaccg ccgccgggat ccgttcgttc gagaggtccc
     1381 tgccgtcggg cgacgaccgt gccggggtca cacaggacgt caggacgaac ggaagggcca
     1441 gtgcggccac gacggaaaag cgccggaaca ggggcatgcg tgagcgagag gtcatgaagg
     1501 ccttcacggg atacgggaga aaagggggca gccgggcggt ggggttcagc tacacaccgc
     1561 ggtcgcgacg cgcatcagat cgatcgcgcg ccgcttcgtg aactgccgga atttccgcat
     1621 gccgtggacg ctatgcaggg ggcgaaaggc ggtcaaggcc tgtccgtcgg ctccgcaacg
     1681 acaccttcgt ggccgtgtca tcttccggaa acgcgccgcc ccgaaaaggc cgaccagcgg
     1741 ccgtcccgcc gggccaccgt gatgtcccgg ccgaagcatg cggtcagcag ggagtcggtc
     1801 aggacctcgt ccaccggccc ccgggacagg atccgtccct cgcgcagcag cagggcgtgg
     1861 ctgacggccg ggaacagctc ctccagatgg tgggtgaccg tcacggtggc cagctgcggc
     1921 ctcccctcgg ccagctggtg catcgcctcg acgaggtcct cgcgggaggg caggtccagg
     1981 gcgttgaacg gctcgtccag gagcagcagc gccggatcgg ccatcagcgc cctggcgatc
     2041 aggatccgcg cccgctgccc gcccgagcag accccgtacg gccggtcggc caactccttg
     2101 acgcccagct cggtgagcag gtcgcacgcc cggacgcgga cctcgtcgtc gtacgtccgc
     2161 cacaagggct ggacggtgcc gctgtggccg gtgagcacga ccgcgtgggc ggtgaggtcc
     2221 tgcggcacgc gctgggacgt gctgacgtgg ccgatgcgtg cccgcagttc acggacgtcc
     2281 acccggccga gccggctgcc gaggacctcg acggtgcccg tggtggggtg catgagcgcg
     2341 ccgaggagcc gcagcagggt ggtcttcccc gcgccgttgg cccccagcag cgcccagtgc
     2401 tcgcccggcc ggaccgtcca gtcgacgtcg tcgaggatca gctggtcggt ggtgaagcgg
     2461 cgcacgctca cgtcctggag ccggagcacg tccgcctccc gctcgttcac ccgggagttg
     2521 gctgtctggc cggtcatgcc gtggctcctt cgcgcgcggt ggacccctcg ttcggtcacc
     2581 gggcacagta gatgtactca ccacacgcct gccggtccgt ccgcttcctg gacggtgggc
     2641 gggcggcagc gggggcactc agacgcggat gagcccccgt actcatccgc ggcaccgggc
     2701 ccggctccta gggtggcgcc gacggtggga cacggagggg gagccatggg gagtcggggc
     2761 gcggtacggg ggagcgggcg gcggcgggcg gggcgcgtcg gcgtcggcct cgcggccctg
     2821 ctggtggggc tgctcggcac cggctgcgcg gcgttcgaca ccgaggacga cgtgcggcgg
     2881 gcccgggagc tcgccgagga gtcgtacccc ggggaactcg aggtcgtcga cgcccggatc
     2941 ctgttcccgg agtccaccgg ctcggaggtc accctggctg tcgccgacga cccggacgcg
     3001 gccgtcaggt tccggatcga cgcggccaag gaccgctgcg acggcggccc gaactgtgcg
     3061 gacgccctcc gcgaggcggt ggaccgggcg cggcgggagg ccggacagct gcgcgcgatg
     3121 cgcgacgcct tcgacggctg cgggcatccg ctcctgggca cggacgagaa gctgacggcc
     3181 ccctggatcg aggctcgggt gaccgatcgg acggtggacg acgtcctcgc ccgggtcggc
     3241 gcctgtgtgc agcgctgggt caccgctcgc gcggagcggg atcccggtgc ggcgccggag
     3301 tgggtcaccg tcaacctcgc ggccccgggc gcggcggacg acctcccgga ggcgaagagc
     3361 acgttgccca ccgtcgtgcg gttcacccac ggccgccggc tcgccgccct ggcgcaggat
     3421 ccgtactacg tggccgccta cccggtcggc cgggacgcgg accgcaccgt cgacgccgcc
     3481 gcggccaccc ttcggatcgt gtcgcccttc gaggagcggc aggccttctc ccggcgcatc
     3541 gacgcgtcgg tcctgcccgc gctgcgcgag acgtacccgg acgccgtgac ggccggtggg
     3601 gcgggaatgg gggtctggcg actggagcag gggaccgtgc gccgcatgcg cggctacgtg
     3661 ctgttctgcg agcggccgcc cgccgacggc aagcagtgct tcggggacct ggcggccctg
     3721 gtgagctcgg acccggcggg ccgcgacgcc gaggtcgtcc ggatcctcac ggacatccgg
     3781 gacgagcacg gggtcctgcg cctgcctccg cggtgacgga gacggacgca ggaccggtgc
     3841 agcggggcgg aaggcgtcag acgcccgcca ccgactggat ccaggagcgg taggcggtca
     3901 cgttggtgta cgccgtggtg gtctgccggt cgctggtcga ggcgacaccc acctggacgc
     3961 cgccggccat catcggaccg ccggagtcgc cgcccgcggt gatgccgtcg acgggacggg
     4021 cgcatatcgc ctggccgtag taggcgtcgt aacaaccccg ggtgacgctc acgttggcga
     4081 ccttgaggta ctgggactgg cagttgatct ccgagccgca gcgggaggtg gcgccccagc
     4141 cgtagacctg cacggtctgg ccgacccgca ccgtgcccgg ctgaccgagg cgggcgtagg
     4201 tggcggagac ggagcggtcg aggcggacca gcgcgaggtc cgccgagggg ctggtgacgg
     4261 tctggacgcc gttggccacc gtgccgccgg agccctggtc gaggctgccg atgcggaagg
     4321 cgaggttgcc gccgctgacg cagtgcttgg cggtgaggat ccaggtgggg gagatgatgg
     4381 tcgaggtgca ggtctgctgg ccgcccgaga acagccgtgc cgcccagggc gcgttctgcg
     4441 cgtagccgcc gccgatgatc ggctgggggc cgccgtcacc gggccggggc tccaccgccg
     4501 aggcgctcgg ggcgagggtg agggcggaca gcagcgcggc cacgagggcg gccagcaggg
     4561 tggggacgag tctcgttgtt cgcaaggctc ctcgattccg acgacacgcg cctgggcgcg
     4621 tgctgatgtg tgggggcgcc cacagcatgc cgggccccgc caccggccga acagtcccgg
     4681 cttcgcataa cgccgtgtta tgcctgaggg ccggggcggc cggggcggcc ggggcggccg
     4741 gggcggccgg gagggggcgg ccggggaggg gagcggcgtt cgagggccgg acagggccta
     4801 gcggagcagc agttgtacga gggcgaccgt gccgaccgtc acgaccagta tccgcaggac
     4861 cgtggggctg aagcggcggc ccaccttggc gccgacccag ccgccgaggc ccgagccgac
     4921 cgcgaggagc ccgacggcgg tccactcgaa gtcggcggcg aagaggaaga agagcgcggc
     4981 cacggtgttg acgagggcgg agaggacgtt cttgacgccg ttgagacgtt gcaggggttc
     5041 gtccaggagc atgcccatca gggacaggta gatgatcccc tgggcggcgg tgaagtagcc
     5101 gccgtagacg ctggccaggg ccaggccggt ctggagcagc ggaccgccgt cccggcgggg
     5161 cgaggcgccg gtgcgggccc ggcggcgctg gaccagccgg ccgatctgcg gctggaaggc
     5221 caccagcagc agggcgagtc ccaccaggac cggcacgatc gtctcgaagg cgtcggcggg
     5281 cagcatcagc aggagggtgg cgcccccgag gccgcccagc agcgctccgg cgccgaactt
     5341 caggacccgc cggcgctggc cgcgcagctc ctcgcggtag ccgatggccc cgctgatgga
     5401 gccggggatc agaccgagcg cgttggagac ggtggcggtg accggcggca gccccgtggc
     5461 cagcagcacc ggaaaggtga tcagcgtgcc ggagccgacg acgctgttga tggcgccggc
     5521 cccgacgccg gccgcgaaca ccgcggccat ggcctccggt gtcaccccgt gccgcctcgc
     5581 cccggacccc tgctcggccg gaaggtgtct tgtgcatctt tcacggggcc gactgtaccc
     5641 accgctccga tccctgtgtt tgccggtctc aaccgctcgc gttcaggcac ttcttgacgt
     5701 taattcacct gatcatgcgg tgatacgatc accgcgtttg cggagcgggc ggatgggtga
     5761 aagacggcat ccccgacgta aagggcagcc cgggcagcta cccccggtgc gggcagtcca
     5821 ccggaccgcc cgcgcggacg ggaattcagc aagccggctg tcagtcgcct gaagagagtc
     5881 ttatgacgga atacacaggg aaccccttgc tctgggtcgc cctcgtcgcc ctcgtcgccg
     5941 ccgccgtgct catcagccgc cagcgcaagg cggcacgggc gttgcggcag caggtccagg
     6001 ggctcaggga tcactacacc gagctggaga gcgattacgg gaagtccgtg caggccgccc
     6061 aggagcgggc cgaggacgag acgaagacgg tgctgaaatc cgccatgcgg acccttcagg
     6121 gcctcgccgc cgaacagcag ctggtgctct cgcggctgca gaccaagtac ggcgactccg
     6181 ccctcctcca ggacctgctg gagatcgatc acaccaactc gcagttcggc cggcgggccc
     6241 agtccatcgc cgtgctgtgc gacggctggc tcggcggccg gcgcgacacc gcctcggtct
     6301 acgacgtggt gcgcagcgcc cagggacgca tccggcactt ccgccgggtg gacatcctct
     6361 cccaggtcga cttcggcatc accagccgtg ccgtcgagcc cgtcgccctg gccctcgccg
     6421 agctgctcga caacgccacc agctactcca gccccgacac cgtcgtcgag atcaacatcc
     6481 ggaccgtgcc caagggcatc tgcgtcgtgg tcgacgacgc cggtgtcggc atgagcgacg
     6541 aggagcgggc ccgcgccgac aagctgctcg ccaccgagcg agcctcgggc gtggcggggc
     6601 tcggcaaccc gccgcagttc ggcttcgccg tcatcggcct gctgtgcgaa cgattcggct
     6661 tcgaggtgtc ggtggactcc tcctccccct acggaggtgt acgggcggtg gtcctgctgc
     6721 cgcacgaact gctcaccgcg atgccggaga agaaggcccc cgccgccgcc ccggccgcac
     6781 gcggtaccgc ccggccggtc ccggacggcg gccccgaggc cgcgctcacc tcctcccaga
     6841 ccggcgacgg tctgccccgg cgccggcgca agcggccgat ggccatcgtg cccggcagcg
     6901 cgtccagccc ccgcgcggcc ggccgctcgg actccgaaca ggcacaggtc atgggcgcct
     6961 tccagcgcgg aacgcagtcc ggccgggtca ccgagcagga ccgagcggac cgcacggacc
     7021 gtccggacag cgccggccgg acgagcgaca cacctggtgc aagcagcgaa ggacatgagg
     7081 tctcgtgaac gacgatctgt catggatgct cgacagcgcc ctggagattc caggcgccct
     7141 gcacgcggtc ctgatatccg ccgacggcct gctgatggcc cggacgcagg acttcgacaa
     7201 ggacgacgcc gaccgggtcg ccgcggcgat gagcggcgtg cagtcgctca gccgcaccct
     7261 cgccttcttc tgtgaggacg ccggccagtc ctggcggcag accctggtcg agttcgacgg
     7321 cggctgggtc ttcctgatct ccgccggcga gggcgcctac ctcggcgtgt ccgcgtcccc
     7381 ggaggtcgac atggcggaca tcaccttccg gatgcagcaa ctcgtcgccc agctcggcaa
     7441 gcggctgacg acaccgccgc gcgagaacct cggcgcccgc tcatgaccgg ccacgacggc
     7501 tggcagcccg aggcgccgga attagtacgg ccgtacgtca tcaccaaggg gcgcggcctg
     7561 cccgacgagg acgacctctc cctcatcacc ctggtcaccg cctccgacgg gcagcagcag
     7621 cggccggccc ggctgtctcc cgaggagcag agcctgctcg acctctgcgc cgccggctac
     7681 ctctcggtcg ccgagatcgc cggacacacc cacttcccgc tgggcgtcgt gcggatcctg
     7741 ctggcctccc tgatggaggg cggccacctc acgacccgcc cgccggtggc ccgtgcccgc
     7801 ctcgcggacc gggagattct ggaggaggtg ctcaatgggc tccgcgccaa gtttggatga
     7861 gcgggactac gtacgcgagg gagcgaccca gaccgcggtc aagatcctcg tcgtcgggca
     7921 cttcgcggtg ggcaagacca ccctcatcgg ctccatctcc gagatcgagc cgctgtccac
     7981 cgaggagacg atgacgcagg ccgccgagcc ggtcgacgac ctcaagggtg tccagggcaa
     8041 gaccaccacc acggtcgcca tggacttcgg ccgcctgacc atcagcgacc gtgtcgtgct
     8101 ctacctcttc ggcacccccg gccagcagcg cttcgtgcag atgtgggagg acatggcccg
     8161 cggcgcgctc ggcgcgctgg tcctggtcga tccggagcgg ctggcggact ccttcccggt
     8221 gatcgacctc atcgagcact acgggctcga ctacgccatc gccgtcaacc acttcgacgg
     8281 cacgccgttg cgcgacgagc gggcgctgcg cgaggcgctc gacctgctcg acgacacccc
     8341 cgtcgtcacc tgcgacgccc gcgacgagaa gtcctcggcc gccgcactga ccaccctcgt
     8401 ccgctacttg ctggaccgca cccgctagga gctgggagca gacatgaacg cccacgacac
     8461 cgccccggtg ccgccacccg gctgcccggc ccacggctcc ggcgcccggg tgccgctgca
     8521 cgggccggag ttcgccgccg acccgcaggc gtactacgag cacctgcgtc actacggggc
     8581 cgcggccccc gtcgaactcg ccccgggggt cgaggcgacg ctggtcacgg actacgcggc
     8641 ggcgctccaa ctgctgcagg actccggaac cttccgcaag gacgcgcgcc gctggcgggc
     8701 cttcaacgag ggcaggatca gcccggacag cccggtcgca cccctgctgg cctaccgtcc
     8761 caactgcatg ttcgccgacg gggccgacca cctcaggctg cgccaggcgg tcaccgacag
     8821 catggcgcgg gtggacaccc ggcgcctgag ccgcagcacc gagcagatct cgggctacct
     8881 catctcccag tttgccaacc gcggttcggc cgacctgctc ggggactacg ccaagcagct
     8941 gccgctgttc gtgttcaacg aactcttcgg ctgccccgcc gacatcggcg accgcgtgct
     9001 gttcggcatc tccggcatgt tcgacggcgt caacgccgag aaggccaccg cggtcctctt
     9061 ccaggcggtg ggggagctgg tcgccctcaa gcggcgcaag cccggcgacg acgtcacctc
     9121 ctggctgatg cggcacgagg ccggtctcga cgacgaggag atggtccacc agctcgccct
     9181 gctcctcggt gcgggcgccg agcccctgcg caacctcctc ggcaacaccc tgcaccggct
     9241 gctcacccac gagcggtacg cccgtgaggg cggtctgatc gacgaggcgc tggacgacac
     9301 gctgtgggag aacccgccca tggccaacta cgccccgcac tatccggccg ccgacaccga
     9361 actggccgga cagcagctgc gggcgggcga cctcgttctg gtcagcttcg ccgcggccaa
     9421 caccggcccg gccctgtcgg cctcccgcga ggcgggcagc aaccgggccc acctcgcctg
     9481 gagcgcgggc ccgcacgcct gcccgtccaa ggaaccggcc cggcacatca cggtcacggc
     9541 cgtcgagcac ctgctcaacg agctgcccga cgtcgaactc gccgtgcccg aagacagcct
     9601 gacgtggcgt ccggggccct tcaaccgggc actggccacg ctgccggccc ggttcacccc
     9661 ggtgcgctcc gcacggcgtg ccgaaccggg gcaggccgcc gcggcggccg agcgggagca
     9721 gacggcgaac acggcccgcc cggccgaaca caagggcatg tggagccagt tcctcaactg
     9781 gctcacacgg tgatctgcgc aacacctcca caacccgccc cattcgcatg aagatcgaac
     9841 ggcacgggta gtgagcaacg cggtactcaa gttgcttacg agtcaaagga ggtgtcgtgg
     9901 accacatatc cacgaacgcc gctttcccgg cgccggaccc cctgataccc gccccccgag
     9961 gcgggtatca ctttgtgcgg ctccgaccgg ggacgggccg gtgaccgccg caccgacggg
    10021 caccgacccg cggcacacac cgacgctcgg ttctctcacg ggcggtcagc tgcgaagact
    10081 cggggcggtc gcgggcctgt cccgagccga cgtcgagacc tacgcacagg tcctgaccga
    10141 gtcactgggc ccggcggccg agcggccgct gagcctgccg ccgcccaccc gcaccttcct
    10201 gtccgacgac cacacccccg tggagttctc cctctccttc cgaccggacg cggcaccctc
    10261 cgtgcgggtc ctcgtcgaac ccggctgcgg cgcagacagc ctggctcgca acggccgtgt
    10321 cggactcgag gcgatccggg ccatggcgcg gcgctggcac ttcgccaccg acgtcctcga
    10381 cgaactccgg gacctgttcc tgccgcccga tccgcagggc cccctcgccc tgtggtgcgc
    10441 gctggagctg aggcccggtg gcgtacccaa ggtgaaggtc tatctgaacc cggcggcagg
    10501 cggggaggaa cgttccgccg cgacggtgcg cgaggctctg cgccggctcg ggcaccggca
    10561 ggcgtacgac ggtctgcccc ggggcgccgg acatccgttc ctcgccctgg acctcgggga
    10621 ctgggcggaa ccccgggtga aggtgtacgt gcggcacgag aacctctcgg ccggccaggc
    10681 cgggcgcctg tcccggatgg actcgggccc cgggcccgcg gcggtcgagg gcttcttccg
    10741 cacggccgcg ggtctcggac ccgacgcgac ggggctcggc ggaaggcccg gcctgtcgtg
    10801 ccactccttc accgacacca caaccgcacg gccgagcgga ttcaccctgc acatcccggt
    10861 cagggactac gtccggcacg acggggaggc tctggcccgg gcgtcgagag tgctgcgcca
    10921 ccacggcatg gacgcctccg tgctcgaccg cgccctggcg gccctcaccg agcggcggcc
    10981 cgaggacggg gtgggcctga tcgcctacct ggccctggcc caccagcggg accaggcccc
    11041 gcggatcacg gcgtacctct cctcggaggc gtacgcggtg cggccgccgg ccgtggagac
    11101 cgtcggccga ccggtgccgg tgtcctgacc ggaccgtccg cacccgacgg ggctcccggt
    11161 gcgatccccc gggagccctc gtcatggacc cggccgggcg ccgtcgcgga cgcgcgcggc
    11221 gacgccgggc ggggcactca cacgggcagc gactcccgga acccggccag gtaagggccc
    11281 acgtcgacct ggatcgaggc cccttcggtc cggccgtagc gctggacgat gccggtgagg
    11341 tacgtgccga tctcctcgcg catctcctcg gccgcgggca gtgccgcggc accgtcgatc
    11401 aggcgggcca cccactctgc ctgggcctcc acgagacggg tgatcgcgcc cacggggcgc
    11461 accagcccga cgaagtacag accgggccgg tccgccggga cgacccgccg gtacagctcg
    11521 accgagccgt ccgccgccac cgggcagccg gccggcagga acgggaaggt catgtggaaa
    11581 ccggtgcagt agacgaccgc gtcggcgggc tcggaactgc cgtccgtgaa cacgacccgg
    11641 tcgccgtcga acgaggcgat cgcgggcttc ggcgtcaccg cgccgtgccg gatccggctg
    11701 aggatctcgt ccgagagggt cgtcgcggag gagaagaccg ggtggtcggg ctcgggcagg
    11761 ccgtagtccg acagcctgcc gcgcgcgacc agcagggcct gctccaccca cttgcgccgc
    11821 tcctcgaagg acatctcgtt ccaccagggg gcttcggcga tctcgtcgac cgacatcccg
    11881 aacagctgct tgggcacgat gtgcagcccc cggcgcaccg acagcagcgt ccgctccgcg
    11941 tgccgggaga ggtccgccgc gatgtccacc gcggaggcgc cgaggcccac cacgacgacg
    12001 cgccggccgg cgaagtcgct gccgtcgcgg tagtccaggg agtgaagaat cgttccggcg
    12061 aaggagtcgg caccggccgg cagggggtcg ggcagggccg gatcggtgtg gtgccccgag
    12121 gcgacgacca cctgatcgaa ccggcgcgag gtacgcgcgc cgtccgcgcc cctgctgacg
    12181 acggtccaca ggccgtcggc gtcctggcgg acggagacca cctcggtccg cagctcgacg
    12241 tggccgagca ggcccgccca ctcggcgaag gaccgcaggt aggcggcgac ctggctgtgc
    12301 cgggggtaga gcgggtacga ctccggcatc gggaagtccg cgtaacccgt cagctgcttg
    12361 gcggtgttca ggtgcagggt ctgatagccc ggaccccgct cgccggcccc gggctgacgc
    12421 cagatcccgc cgacgtcggg tgccttctcc aggcagacga aggagatgcc gcgctccttc
    12481 agggcatggc ccatcgccag gcccgacagg cctgcaccga tcacacacac acgcacggga
    12541 cgtcccccca ggatgtactc aacctccccc gatcatgcac ttactgccca tccgtatctc
    12601 cacgcacacc agaacgaccg gggaacggac gtgtcggtga tcacgtttca cgcgcctcgc
    12661 aggtcccaca cccggcggat cttgccgagc gagcgctcca gcgtctccgg ctcgacgacc
    12721 tccacctcga cgctgacccc cacaccgtcc ttgacgccct gggcgatcgc cctcgcggcg
    12781 gcctcgcgcc gctcggggcc ggcgtcgggg cgggcctcga cccgtacggt catgtggtcc
    12841 atacggccgc gttcggtgag ccggatctgg aagtgcgggg cgacgccggg ggtgcgcagc
    12901 acgatctcct cgacctgggt cgggaagacg ttcaccccgc gcaggatgat catgtcgtcg
    12961 cagcggccgg tgaccttccg catccgccgg aaggcgggac gcgcggtgcc gggcagcagc
    13021 cgggtcaggt cgcgggtgcg gtaccggatc accgggagcg cctccttggt gagggaggtg
    13081 aagacgacct cgccctcctc gccctcgggc agcaccgcgt ccgtgagcgg gtccaccacc
    13141 tcggggtaga agtggtcctc ccagatgtgc agtccgtcct tggtctcgac gcactcctgc
    13201 gccacaccgg ggccgatcac ctcggacagg ccgtagatgt cgacggcgtg gatgtccatg
    13261 cgctcctcga tctcgcgccg catctcctcg gtccacggct cggcgccgaa gatgccgacc
    13321 ctgagggagc tgccgcgcgg atcgatgccc tggcgctcga actcgtcgag cagcgtgagc
    13381 atgtaggagg gggtgaccat gatgatctcg ggccggaagt cctggatgat ctgcacctga
    13441 cgtgccgtca tgccgccgga cgccggaatc accgtgcagc cggcgcgctc cgcgccgtag
    13501 tgcgcgccga gtccgccggt gaacaggccg tagccgtagg agatgtgcac cttgtggccc
    13561 gggcggccgc cggcggcgcg gatcgaacgg gctatgacgt ccgcccacat ggacaggtcg
    13621 ttctcggtgt acccgacgac ggtggcacgg ccggtggtgc cgctggaggc gtgcacgcgc
    13681 cgcacgtcgg acatcgggac cgcgaacatg ccgaaggggt aggtgtcccg caggtccgcc
    13741 ttggtggtga aggggaaccg ggacaggtcc gccaggctgc ggcagtcctc gggcgtcacc
    13801 ccggcggcgt cgaacttctt gcggtacagc tccacgttgt cgtaggcgtg ccgcagggtc
    13861 gcgcgcaggc ggtcgagctg gagttcgcgg agctgctcgc gggagagccg ctcggcgtcg
    13921 tcgagcaggt cgtgggggag gggctcgccc ggtcgggggg ccggggccgc cccggtcgtc
    13981 ggctcgctgc tcatcgcgac tccttcgtcg tcgtgccggg cgcctcgcgc gccgtgtcgt
    14041 cccgggcgct gcggctgcgg ccgcggaact ccgcgatcag ctcgtcgccg cgccacacgc
    14101 tcacgtcgta gatgccgctg cgtccgaacc gggcacgctc ctcggcgcgg gcgaccagca
    14161 cgtcgccctc gcgggccggg gcgacgaaga cgatgtcggc gccggccgcg accgtgaccg
    14221 gtccgtggct gttgcaggca caggcgaacg cggtgtcggc gaggaggaag aggaagccgc
    14281 cgtgggcgat ccggtgtccg ttgaccatcg ccggggtcac ggtcatcctg gcgaccgcgg
    14341 tgcccgcgcc gtgctcgacc agttcgatgc ccagtccccg tgacgcctcg tccgcggcga
    14401 acatcacctc cgtgggcgtc cgcccagtgg tctgcgacac cgtatccacc acccattctc
    14461 ccgaccgacc attcggttag ctcgcgacag ggccaagtaa tccagccacg cggcggcgct
    14521 gtcaagagtg tgaccggcgg gcgtccggct cttgcccggc gcgcggaaac acgtcacact
    14581 gagaccgaac gaatggtcgg ttgggaagct ggtgacgatg accacgacac acgccgccga
    14641 ggcgccgccc ccggacgcgc cggacgggct ccaggagcac ttcgacgcga cgatcgcgcg
    14701 cgaccagcgg gtcgagccgc gggactggat gcccgacggc taccgcaaga cgctgatccg
    14761 gcagatcgcc cagcacgcgc actcggagat catcggcatg cagcccgagg gcgagtggat
    14821 cacccgggcg ccgtcgctgc ggcgcaaggc gatcctcttc gccaaggtcc aggacgaggc
    14881 cggccacggg ctgtacctgt actcggccgc cgagacgctc ggcgcggacc gcgacgacct
    14941 caccgagcgg ctgatcgagg gccgccagaa gtactcgtcg atcttcaact acccgaccct
    15001 gagcttcgcc gacgtcggcg tgatcggctg gttcgtggac ggcgccgcga tctgcaacca
    15061 ggtgccgctg tgccgcagct cgtacgggcc ctacgcgcgc gcgatggtgc gcatctgcaa
    15121 ggaggagtcc ttccaccagc ggcagggcta cgagctgctg atgacgatga tgcgcggcac
    15181 cgacgcccag cgcgagatgg tccaggacgc ggtggaccgc tggtggtggc cgtccctgat
    15241 gatgttcggc ccgcccgacg acgcctcgcc caactcggcg cggtcgatgg cctggaagat
    15301 caagcggcac agcaacgacg agctgcgccg gcgcttcgtc gacatgaccg tcccgcaggc
    15361 cgagaagctc ggcgtcaccc tgcccgaccc ggagctgcgc tggaacgagg agagcggtca
    15421 ccacgacttc ggcacccccg actgggacga gctgatgcgg gtcatcaagg gcgacgggcc
    15481 ctgcaacgac cggcggatgg agcggcggcg caccgcccac gaggagggcg cctgggtgcg
    15541 cgaggcggcc accgcccacg cggccaaaca ggcagcccgc gcggagaagg gagcggcggc
    15601 atgacccccg agaaggccca gcagcccgac aagcggggct ggccgctgta cgaggtgttc
    15661 gtgcgcggca agcgcggcct caaccacgtc cacgtcggct cgctgcacgc cgccgacgac
    15721 gcgatggccc tcacccacgc ccgcgacctc tacacccggc gcaacgaggg cgtctccatc
    15781 tgggtggtcc gctcggagca catcgccgcc tccacccgcg acgagaagga ccccttcttc
    15841 gcccccagcg ccgacaaggt ctaccgccac ccgaccttct acgacatccc cgacgacgtc
    15901 ccgcacatct aggagcaggg catgagtgac gaccacgtct acctcaccct ggccgagggg
    15961 cacgaggacg acacccgctg ggcctacggc accggcttcg aggacccgct gcacggcgtc
    16021 gacaccaccg tccccgaggg cgtcgacgcc cgggcgctgg ccgccgagtg cgtggcgctc
    16081 gccgacgacg ccctggtcag cgcccagcgg ctcgccgagt gggtcacccg cgcgcccgag
    16141 ctggaggagg aggtggcgct ggccaacatc gggctcgacc tcctcggcca ggcccggctg
    16201 ctctactccc gcgccggtca ggccgacggc accggccgcg acgaggacgc ctacgcctac
    16261 ttccgggacg ccgacgactt ccgcaacgtg cggctggccg aactccccgg cggagacttc
    16321 gcgttcgcgg tcgtccggct gctggtgctc tccagctggc ggctggccca cttccggcgg
    16381 ctcgaggccc acccggaccc ggtgctcgcg gcggtcgccg ccaagggcgt caaggagctg
    16441 acctaccacc ggcagtacgc tgccgagtgg tgcgtgcgcc tgggcgacgg caccgacgag
    16501 tcgcaccgcc ggacgcgcgc cgcactggac gaggtcgccc cctacctggg cgagctgcac
    16561 acggcgtacg acgtgcggga cgaggtcgcc gaagacctgc gccaggtcac cggggccgcc
    16621 gggctgaccc tgccggttca ccgcccgctg cccggctcgg gccgcgccgg cgagcacacc
    16681 gagcacctgg cgccgctcct caccgagctt cagggcgtcg cccgcgccca cccggaggcg
    16741 acatggtgac cggcggcccc gcactcctgg acgcccaccg cgcccggcac gtcgccgagc
    16801 aggtgcccga ccccgagctg cccatgctga ccctcgccga cctcggcgtc ctgcgcgacg
    16861 tcgaggtgac cggggacggc acggtcgtgg cgagcctgac ccccacctac tcgggctgcc
    16921 cggccatggc cgagatgcgg gcggacgtcg ccgcgcggct gcgggacgcg gggtacccgc
    16981 gcgtggagat ccgcaccgtc ctggacccgc cctggaccag cgactggatc accgagtcgg
    17041 gccgcctgaa gctcaccgag cacggcatcg ccccgccggg ggccgcgccc cggggtcccg
    17101 tctccctggt gctgtcgccc atccggcccg cggtgccctg cccgcgctgc ggctcggcgg
    17161 acaccgagga gacctcccgc ttcgccgcca cgtcctgcaa ggcgctgtgg cgctgccggg
    17221 cctgccgcga gccgttcgag tacgtcaagg agatctgaat ggccccgacc gcccccgtcc
    17281 cggcggcccc cgtgcgcacc cgccgccgtc ccgccttcca cgccctgcgc gtcgccgccg
    17341 tggagcggct gtgcgcggac gccgcggccg tgagcttcga gatccccgac gagctggccg
    17401 gggagttcgc cttcgcgccc ggtcagtcgc tcaccctgcg gcgcgaggtg gacggccggg
    17461 acgagcgccg ctcctactcg atctgcgcgc cggccggttc ggcgccgcgc atcggggtgc
    17521 gggtggtgcc gggcgggctg ttctcggcgt ggctggtgga ggacgtgcgg ccgggcgaca
    17581 ccgtgcaggt gatggccccc accggcctct tcacccccga cctgagcgcc cccggccacc
    17641 acgtgctgat cgcggccggc tcgggcatca ccccgatggt ctccatcgcc gagtcggtgc
    17701 tcgccgccga cgaccgctcc tccgtcaccc tcttctacgg caaccgccgc agcgacacgg
    17761 tgatgttcgc cgacgaactg gccgacctga aggacctcca cccgacccgc ttccacctcg
    17821 cccacgtgct ctcccgcgag ccccgcgagg cggaggtgct ctccggccgc ctggacgccg
    17881 cacggctctc ggcgctcatc gactctctgc tggacgtgga gagcgcggac cattggtggc
    17941 tgtgcggacc gcagggcatg gtcgccgacg cccagcaggt cctgaccggc ctcggcgtcc
    18001 cggcggagcg tgtccaccgg gagctgttct acgccgacga cgagcccgtg cgggaggtcc
    18061 ggcacgagga gagcggtccc gagggccccg tcagcgaggt caccgtcgtc ctggacggcc
    18121 gctccacgac cgccccgctc tcccgcgagc ggtcggtcct cgacggggcc cagcagaccc
    18181 gccccgacct gcccttcgcc tgcaagggcg gggtctgcgg gacctgccgg gccctggtca
    18241 ccgacggcag tgtcgacatg cgccgcaact acgccctcga ggtggccgag gtcgacgcgg
    18301 gttacgtcct cacctgccag tcgtacccgg tctcggagaa gctgaccgtg gactacgaca
    18361 gctgaccccg ggacggtccg gccccgctca ggccgggttg tcgccgtggg tgagggtctc
    18421 ccaggcgacg aagaggttgt tcgtgccgga ggggcgggtg cgctcggtca gggcctgggt
    18481 gttggtcatg gcgaagccga ggcggttgtg catcgcgttg tagccgacct cggtgaccgg
    18541 gcccagcccg aggtcgagtt ccccgccgca cagccagtcc ggcgcggccg cgccctgctc
    18601 gtacttcgcc tggaagccga gcgcgtgccg caggcgctcg ccgacgtcgg tgccgtacag
    18661 gtcctggccc tggatccggc tggtctcggc gacgtgcgag atggacgcga tgccgtatcc
    18721 ggtgtgggtg aggtcccggc aggtctcctg ggtgaggccg gtgacgaagg tggactggcc
    18781 ctgccagtac ctgacgatct tgtcccgggt gtcgaggtgc tggctcggga cggtcttcgg
    18841 cagggctccg tcggactcca ggtacacgta cgcggccgtg cgggtgcgga acctggccat
    18901 ggccctgtcg taggaggccc ggtcctccag gaagacggag atgccgacgg cggcctccgt
    18961 catcgtcagc tcccagttgc cgttggagtt cgacccgttg atgatctcgg gcaggtagac
    19021 gtcccggagc atggtggcga agcggccgga gtcggcccag tttccgccgt acgtgtactt
    19081 gatgatctcg gcggccttgg gccaggagga cccggcccac ccggtctgca gcggcgcgtt
    19141 gctgtcggtg tggtcccgga gcacggcgga ccaggcgtcc atcagctcga tggacttgcg
    19201 ggcgtaccgc tcgtcacggg tgaggtacca ggccagagcg ttggtgtagg ccgcgatggc
    19261 gtcctcgcgc tcgtcggtgc agccgtggtt cgggttggag taggaaccgc actccaccac
    19321 cgcgcggggc ttcggggtgc ggttcgggtc ggcgtacctg ctcgccgtca gctggtcgaa
    19381 ggcgcccttc cagggctggg ccccggcggc gaccttggcg cggacgaagt cgagttgccc
    19441 ctgggagacg gtgactccgg ggtgcgtgaa cgcggccggc gcggcgtccg cgcggggagc
    19501 ggccgggccg gggccggcca gcagggtgcc gacgagggcg gcggtgaggg tcgcgaggag
    19561 tgcggcgcga gatctgcggt ggcggcgcgt gggagcagag gacatgtggg gggtccatcc
    19621 gttcgagtat gtgaacgctg aatgtctttc tgaacgttcg actgcgccgt gacgataggt
    19681 agagaccaat ggggcgtcaa ggggccacgc gaggaacgcg gagaggtccg ggcccgtgaa
    19741 ggcgcgcgaa cactatgaac gcaacggcgg aaggggtggc tccggctccg ccgcgttcct
    19801 aacatccctg ctcgcagcgc gacttcgcgc cggaccgcag cagagcacgt caggagccgc
    19861 accttgccca cactccacgc tcccgcgcac gacgccgggc ccacccgccg cagaggccgc
    19921 cccgcggtgg tggccgccgc gctcgccgcc gtcctcctcg gcaccctcgg caacgtgacc
    19981 gccgcccccg cgcgggccgc cgatcagcct gcgggcgcgc agccggtggc cgccgactgt
    20041 ccgcccgccc tcgcggacca ggccacctgc tacaccggcc aggacgccaa cggggccttc
    20101 tacgcgatgg ccgtgccgca ccgctggaac ggctccctcg tcgtgcacgc gcacggcggc
    20161 cccgacctcg gcgacgcctc cgacccggcc cgcagcaccg aggacctcga acgctgggcg
    20221 gtgatggtcg accagggata cgcctgggcc ggctcctcct accggcgcgg cggctacggg
    20281 gcccgcatgg cggccgccga caccgagaac gtacgccgcc tgttcaccga ccggttcggc
    20341 cggcccgaac acacctacct ccacggccag tcctggggcg gcaacgtcgc cgccaagacc
    20401 gccgagacct acggccggcg gcccggggcc tacgacgggg tactgctgac caacggcgtc
    20461 ctcggcggcg gttcgcgcgg ctatgactac cgcgtagacc tgcgggtggt ctaccagtac
    20521 tactgccaca accatccgcg ccccaccgag ccgcagtacc cgctgtggca gggcctgcgc
    20581 cccggctcca ccatgacgac cgccggcctg cgcgcccgcc tccaggagtg cacgggctac
    20641 gcctccgacc gggcggaccg gaccgcgtcg cagcagcgca acctcgacga catcctcgcc
    20701 gtcaccggca tccccgagcg caccctggag tcccatctcc ggttcgccac cttcacgttc
    20761 cgggacatcg tgaccaaccg gctcgacggg cggaacccgt ggagcaaccg gggggtgcgc
    20821 tacacgggct cgcacgacga caaggcgctc aacgccggtg tcgagcgctt ctccgccgac
    20881 cccaccgcac gccgggacct gtcctgggac agcgacctca ccggcagggt ctcccttccc
    20941 gtcctcaccc tgcacgccat cgacgacccc acggcgttcg tcgagcacga ggcggcctac
    21001 cgcgccacgc tccggggggc cggccgggac gggaacctcg tccagacgtt cacgaacgag
    21061 cacgagcaca gctcgctgag cgactccgag tacgccaact ccctctcggc gctggacgcc
    21121 tgggtccg
//
